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See detailCHANGEMENT CLIMATIQUE: Manger - Bouger
Ozer, Pierre ULg

Conference given outside the academic context (2015)

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See detailEpistasis associated to inflammatory bowel disease (IBD) in humans
Gusareva, Elena ULg; Wei, Zhi; Traherne, J.A. et al

Poster (2015, October 05)

Gene-gene interactions underlie biochemical pathways and have been well demonstrated in model organisms. Very few examples exist on replicated epistasis in humans. Here, we performed genome-wide scans to ... [more ▼]

Gene-gene interactions underlie biochemical pathways and have been well demonstrated in model organisms. Very few examples exist on replicated epistasis in humans. Here, we performed genome-wide scans to detect epistasis associated to Crohn’s disease (CD) and ulcerative colitis (UC). We used extensive data of the IIBDGC consisting of 18277 and 14224 CD and UC patients, respectively, and ~34050 healthy controls from 15 European countries typed on the Immunochip. At first, we removed rare variants at MAF<0.05 and filtered common variants at linkage disequilibrium (LD) of r2>0.75. To limit our results to independent effects, SNPs on chromosome 6 (which contains the HLA locus), were furthermore pruned to ensure an LD of r2<0.35. We adjusted the binary traits, CD and UC, for population stratification by regressing out the first 5 principal components in R-3.0.1. The study cohorts were randomly stratified into two subgroups (referred as discovery and replication). We then performed screenings for epistatic interactions with new adjusted trait values in the two subgroups using multidimensional reduction tool MB-MDR with permutation-based (step-down MaxT) multiple testing correction and significance assessment at 0.05. We identified 14 and 6 SNP-pairs associated to CD and UC, respectively, which were concordant between the discovery and replication groups. All SNP-pairs involved concomitant variants located on the same chromosomes (for CD at 1p31.3, 5p13.1, 16q12.1 and for UC at 1p31.3, 6p21.3). A more detailed investigation of these findings, as well as the implementation of different analysis protocols, will further increase our understanding of possible epistatic mechanisms underpinning IBD. [less ▲]

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See detailDe l'application des mathématiques en biologie : acquis et perspectives
Brostaux, Yves ULg

Conference (2015, October 03)

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See detailLeucocytes and lipid particles filtration in suction blood during cardiopulmonary bypass: impact on kidney function evaluated with a monocentric prospective randomized study.
LAGNY, Marc-Gilbert ULg; KOCH, Jean-Noël ULg; BLAFFART, Francine ULg et al

Conference (2015, October 03)

OBJECTIVE: Cardiac surgery may be complicated by acute kidney injury (AKI). Cardiotomy suction during cardiopulmonary bypass (CPB) is deleterious. A few studies have demonstrated that shed mediastinal ... [more ▼]

OBJECTIVE: Cardiac surgery may be complicated by acute kidney injury (AKI). Cardiotomy suction during cardiopulmonary bypass (CPB) is deleterious. A few studies have demonstrated that shed mediastinal blood (SMB) suction during cardiopulmonary bypass (CPB) can increase inflammatory response and lipids emboli. These 2 factors contribute to the development of postoperative AKI. The RemoweLL (RemoweLeucoLipids, Eurosets™, Italy) filter is a recent designed cardiotomy with a multilayer filter for activated leucocytes filtration and a syphon for lipid particles sequestration. The SMB can be collected and filtered in this supplementary cardiotomy added to CPB circuit. The aim of this monocentric prospective study was to compare the specific RemoweLL cardiotomy filtration for suction blood during CPB and a conventional 40 µm filter (Admiral, Eurosets™, Italy). The primary goal was to evaluate the AKI within 48 hours after surgery using the Acute Kidney Injury Network classification (AKIN classification) but also measuring early specific biomarkers of AKI: serum Cystatine C and urinary neutrophil gelatinase-associated lipocalin (NGAL). METHODS: Sixty patients scheduled for elective cardiac surgery (aortic or mitral valvular combined or not with coronary bypass grafting) with a glomerular filtration rate (GFR) > 45mL/min. were randomly into 2 groups for SMB filtration: - Groupe 1 (n=30) with RemoweLL cardiotomy (Leucocytes and lipids filter); - Groupe 2 (n=30) with Admiral cardiotomy (conventional 40 µm filter). All components: venous reservoir, oxygenator and surface treatment were similar in both groups. [less ▲]

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See detailPour une vision intégrée du prévenir et du guérir
Vanmeerbeek, Marc ULg

Scientific conference (2015, October 02)

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See detailPréface
Marganne, Marie-Hélène ULg

in de Haro Sanchez, Magali (Ed.) Ecrire la magie dans l'antiquité. Actes du colloque international (Liège, 13-15 octobre 2011) (2015)

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See detailBaccio Bandinelli théoricien. Réflexions sur le "Libro del Disegno"
Marique, Charlotte ULg

Conference (2015, October 02)

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See detailNeurosciences et Psychiatrie : parallélisme ou convergence ?
Desseilles, Martin ULg

Scientific conference (2015, October 02)

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See detailNovel chitosan hydrogel for the treatment of osteoarthritis.
Henrotin, Yves ULg

Conference (2015, October 02)

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See detailConclusions
Valenti, Gianluca ULg; Miesse, Hélène ULg

Conference (2015, October 02)

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See detailPhénoménologie de l’électrochoc : Une reprise du cas Jonas
Englebert, Jérôme ULg; Cormann, Grégory ULg

Scientific conference (2015, October 02)

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See detailSpectral Variations of Of?p Oblique Magnetic Rotator Candidates in the Magellanic Clouds
Walborn, Nolan R.; Morrell, Nidia I.; Nazé, Yaël ULg et al

in Astronomical Journal (The) (2015), 150

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the ... [more ▼]

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the Galaxy to consist of oblique magnetic rotators. All of these Magellanic stars show systematic spectral variations typical of the Of?p class, further strengthening their magnetic candidacy to the point of virtual certainty. The spectral variations are related to photometric variations derived from Optical Gravitational Lensing Experiment data by Nazé et al. in a parallel study, which yields rotational periods for two of them. Now circular spectropolarimetry is required to measure their fields, and ultraviolet spectroscopy to further characterize their low-metallicity, magnetically confined winds, in support of hydrodynamical analyses. [less ▲]

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See detailLe droit de vote à distance: Emergence d'un objet de recherche et apport au champ de la sociologie électorale
Lafleur, Jean-Michel ULg

Conference (2015, October 01)

Dans cet article, nous présentons tout d’abord l’émergence du droit de vote à distance comme objet de recherche dans le champ la théorie politique et des études migratoires. Ces travaux caractérisés par ... [more ▼]

Dans cet article, nous présentons tout d’abord l’émergence du droit de vote à distance comme objet de recherche dans le champ la théorie politique et des études migratoires. Ces travaux caractérisés par leur dimension exploratoire, nous permettent toutefois de définir le droit de vote à distance et d’identifier les caractéristiques essentielles qui le différencie aujourd’hui des pratiques antérieures. Nous présentons ensuite les travaux sur la diffusion de la norme qui depuis moins d’une décennie ont constitué le principal angle d’entrée de la science politique sur le droit de vote à distance. Dans la troisième et dernière partie de l’article, nous défendons enfin l’intérêt d’une approche transnationale des questions électorales dans les études électorales. Cette approche, comme nous le défendons, permet d’éclairer non seulement le comportement des expatriés mais plus largement la transformation des pratiques électorales ici et là-bas. [less ▲]

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See detailBuilding a bridge between Liege and Asturias : the case of zinc
Peters, Arnaud ULg

Conference (2015, October 01)

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See detailCoherence and many-body effects in the transport of Bose–Einstein condensates
Dujardin, Julien ULg

Doctoral thesis (2015)

This thesis presents investigations on the interplay of coherence and many-body effects in the quasi one-dimensional transport of Bose-Einstein condensates (BEC) through scattering potentials. Such ... [more ▼]

This thesis presents investigations on the interplay of coherence and many-body effects in the quasi one-dimensional transport of Bose-Einstein condensates (BEC) through scattering potentials. Such configurations can be realized with guided atom lasers that provide a coherent atomic beam. An exact theoretical description of the dynamics is out of reach due to the presence atom-atom interactions. Different levels of approximations are nevertheless possible with their strengths and weaknesses. The mean-field approximation, where the dynamics of the BEC is governed by the Gross-Pitaevskii equation, is most commonly used in the field of ultracold atoms. In this thesis the truncated Wigner method is used to go beyond the standard Gross-Pitaevskii description. This method is adapted in order to study the scattering of Bose-Einstein condensates in one-dimensional waveguides where atom-atom interactions and external potentials are nonvanishing only in a finite region of space. In this case, the truncated Wigner method is combined with the smooth exterior complex scaling method and incorporates quantum noise that originate from the vacuum fluctuations in the waveguide. Inelastic scattering is shown to play a major role in the resonant transport of BEC through a symmetric double potential barrier effectively forming an atomic quantum dot. Indeed, fully resonant transmission is prohibited and incoherent atoms as well as collective oscillations are detected in the transmitted beam. It is also shown that inelastic scattering destroys Anderson localization in the case of transport through disordered potentials. The classical (incoherent) ohmic transmission is recovered for finite atom-atom interactions. The validity of the truncated Wigner method is then assessed using the semiclassical van Vleck-Gutzwiller propagator in the Fock space of the many-body system. It is shown that the truncated Wigner method corresponds to the so-called diagonal approximation, and it is possible to identify the leading correction to the truncated Wigner results, which is provided by the so-called coherent backscattering (CBS) contribution. Coherent basckattering in Fock space is a genuine quantum many-body effect that lies beyond the reach of any mean-field approach. For the case of closed Bose-Hubbard models, the relevance of CBS is confirmed by numerically comparing the (classical) truncated Wigner evolution probabilities to the exact quantum probabilities in Bose-Hubbard models: While a CBS-induced enhancement of the return probability to the initial state is clearly seen in the exact quantum simulations of the bosonic many-body system, this enhancement is absent in the classical calculations. The magnitude and dependence of the CBS contribution on gauge fields, which break time-reversal invariance, is numerically confirmed. For the case of disordered open systems, it can be shown that this contribution as well as next-to leading order contributions vanish thereby confirming the validity of the truncated Wigner method. [less ▲]

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See detailStroboscopic phenomena in superconductors with dynamic pinning landscape
Jelic, Zeljko ULg; Milosevic, Milorad; Van de Vondel, Joris et al

in Scientific Reports (2015), 5

Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain ... [more ▼]

Introducing artificial pinning centers is a well established strategy to trap quantum vortices and increase the maximal magnetic field and applied electric current that a superconductor can sustain without dissipation. In case of spatially periodic pinning, a clear enhancement of the superconducting critical current arises when commensurability between the vortex configurations and the pinning landscape occurs. With recent achievements in (ultrafast) optics and nanoengineered plasmonics it has become possible to exploit the interaction of light with superconductivity, and create not only spatially periodic imprints on the superconducting condensate, but also temporally periodic ones. Here we show that in the latter case, temporal matching phenomena develop, caused by stroboscopic commensurability between the characteristic frequency of the vortex motion under applied current and the frequency of the dynamic pinning. The matching resonances persist in a broad parameter space, including magnetic field, driving current, or material purity, giving rise to unusual features such as externally variable resistance/impedance and Shapiro steps in current-voltage characteristics. All features are tunable by the frequency of the dynamic pinning landscape. These findings open further exploration avenues for using flashing, spatially engineered, and/or mobile excitations on superconductors, permitting us to achieve advanced functionalities. [less ▲]

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