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See detailBiologie du développement (partim. animal)
Peers, Bernard ULg

Learning material (2015)

Detailed reference viewed: 35 (1 ULg)
See detailMédiations numériques de la lecture
Barnabé, Fanny ULg

Scientific conference (2015, February 23)

Séance de séminaire sur la médiation que représente le numérique dans la lecture littéraire.

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See detailSolidarities and Learning: Reporting Incidents in a Nuclear Research Center
Rossignol, Nicolas ULg

Scientific conference (2015, February 23)

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See detailLes plantes qui nous soignent : de la tradition à la médecine moderne
Frederich, Michel ULg

Scientific conference (2015, February 23)

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See detailPenser le vieillissement de la population pour la Wallonie de demain
Delvenne, Pierre ULg

Conference given outside the academic context (2015)

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See detailEMODnet regional gridded abundance products: a tool to facilitate ecosystem assessments
Beckers, Jean-Marie ULg

Scientific conference (2015, February 20)

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See detailFAO Training in Crop Yield Forecasting - Remote Sensing - Method for Crop Yield Forecasting System (CYFS) from spatial Remote Sensing for Tajikistan. Integration of PROBA-V NDVI images. Belgium - Arlon Campus Environment - January 2015.
Denis, Antoine ULg

Learning material (2015)

This manual has been written for the “Training for strengthening crop yield forecasting capacity of the State Administration for Hydrometeorology (Hydromet) of Tajikistan” that occurred between 12nd ... [more ▼]

This manual has been written for the “Training for strengthening crop yield forecasting capacity of the State Administration for Hydrometeorology (Hydromet) of Tajikistan” that occurred between 12nd January and 7th February 2015 in Arlon – Belgium in the framework of the Food and Agriculture Organization (FAO) of the United Nations Project (GCP/TAJ/007/EC) “Support to Strengthening the National Food Security Information System in Tajikistan”. This manual is intended to cover the Remote Sensing part only of the general Crop Yield Forecasting System (CYFS). Despite written for the Tajik context this manual can serve as an example for all other countries. This manual follows on from the 2 manuals entitled: 1) “FAO Training in Crop Yield Forecasting ARMENIA - Erevan – May 2011 – Remote Sensing”. 2) “FAO Training in Crop Yield Forecasting. Improvement of the Crop Yield Forecasting System (CYFS) in Armenia: a new approach for satellite data integration. ARMENIA - Yerevan - January 2013.” This manual, in addition to adapt the method to Tajik context, integrates for the first time the NDVI images of PROBA-V satellite. These images continue the stopped SPOT-VEGETATION time’s series, from 2014 to undefined future. [less ▲]

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See detailRational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging
Boutier, Maxime ULg; Ronsmans, Maygane ULg; Ouyang, Ping et al

in PLoS Pathogens (2015), 11(2), 1004690

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We ... [more ▼]

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We produced single deleted recombinants using prokaryotic mutagenesis. When producing a recombinant lacking open reading frame 134 (ORF134), we unexpectedly obtained a clone with additional deletion of ORF56 and ORF57. This triple deleted recombinant replicated efficiently in vitro and expressed an in vivo safety/efficacy profile compatible with use as an attenuated vaccine. To determine the role of the double ORF56-57 deletion in the phenotype and to improve further the quality of the vaccine candidate, a series of deleted recombinants was produced and tested in vivo. These experiments led to the selection of a double deleted recombinant lacking ORF56 and ORF57 as a vaccine candidate. The safety and efficacy of this strain were studied using an in vivo bioluminescent imaging system (IVIS), qPCR, and histopathological examination, which demonstrated that it enters fish via skin infection similar to the wild type strain. However, compared to the parental wild type strain, the vaccine candidate replicated at lower levels and spread less efficiently to secondary sites of infection. Transmission experiments allowing water contamination with or without additional physical contact between fish demonstrated that the vaccine candidate has a reduced ability to spread from vaccinated fish to naïve sentinel cohabitants. Finally, IVIS analyses demonstrated that the vaccine candidate induces a protective mucosal immune response at the portal of entry. Thus, the present study is the first to report the rational development of a recombinant attenuated vaccine against CyHV 3 for mass vaccination of carp. We also demonstrated the relevance of the CyHV 3 carp model for studying alloherpesvirus transmission and mucosal immunity in teleost skin. [less ▲]

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See detailTransient internally driven aurora at Jupiter discovered by Hisaki and the Hubble Space Telescope
Kimura, Tomoki; Badman, Sarah; Tao, Chihiro et al

in Geophysical Research Letters (2015), 42

Jupiter’s auroral emissions reveal energy transport and dissipation through the planet’s giant magnetosphere. While the main auroral emission is internally driven by planetary rotation in the steady state ... [more ▼]

Jupiter’s auroral emissions reveal energy transport and dissipation through the planet’s giant magnetosphere. While the main auroral emission is internally driven by planetary rotation in the steady state, transient brightenings are generally thought to be triggered by compression by the external solar wind. Here we present evidence provided by the new Hisaki spacecraft and the Hubble Space Telescope that shows that such brightening of Jupiter’s aurora can in fact be internally driven. The brightening has an excess power up to ~550 GW. Intense emission appears from the polar cap region down to latitudes around Io’s footprint aurora, suggesting a rapid energy input into the polar region by the internal plasma circulation process. [less ▲]

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See detailRegional organizations, international norms and global governance of culture: The EU foreign policy and the diversity of cultural expressions
Vlassis, Antonios ULg

Conference (2015, February 19)

Abstract: The aim of this paper is to explore empirically and qualitatively the links between regional organizations and international norms, by using an institutionalism centered on the actors. It seeks ... [more ▼]

Abstract: The aim of this paper is to explore empirically and qualitatively the links between regional organizations and international norms, by using an institutionalism centered on the actors. It seeks thus to analyze the European Union (EU)’s capacity to act within the global governance of culture, and in particular its ability to promote the Convention on diversity of cultural expressions (CDCE) beyond the EU. What is at issue is of why and how the EU foreign cultural policy (EUFCP) uses the CDCE and its normative framework, of what purposes as well as of how the CDCE influences the EUFCP and its objectives. I argue that the CDCE offers an opportunity for the European Commission to establish itself as a foreign policy actor in cultural affairs. Nevertheless, I point out that the disconnect between the Commission and the EU culture organizations is a serious constraint for the effectiveness of the EUFCP, highlighting that the promotion of the CDCE has been especially instrumental in consolidating the Commission’s actorness in external cultural affairs. And finally, I conclude that not only the Commission’s practices largely rely on the willingness of some member states with strong interests in the cultural area, but also the EU’s interpretations on the scope and the goals of the CDCE are far from convergent. Consequently, the Commission’s ability to be a EUFCP’s agent clearly depends on the sensitiveness of the issue and the EU’s actorness is strongly linked to the context in which the EUFCP is made. [less ▲]

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See detailLes Grecs ont-ils étudié le latin dans l'Antiquité ? Quelques témoignges datant du Haut-Empire
Rochette, Bruno ULg

Scientific conference (2015, February 19)

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See detailLa question de l'acceptabilité sociale dans des projets du SPIRAL
Delvenne, Pierre ULg; Parotte, Céline ULg; Rossignol, Nicolas ULg et al

Scientific conference (2015, February 19)

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See detailDynamic Input Conductances Shape Neuronal Spiking
Drion, Guillaume ULg; Franci, Alessio ULg; Dethier, Julie ULg et al

in eNeuro (2015)

Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness and homeostasis of neuronal signaling. The paper proposes that this ... [more ▼]

Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness and homeostasis of neuronal signaling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current-voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis. [less ▲]

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See detailDUSP3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis
Musumeci, Lucia ULg; Kuijpers, Marijke; Gilio, Karen et al

in Circulation (2015), 131(7), 656-68

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet ... [more ▼]

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet activation is of importance for the development of improved therapies. Recently, protein tyrosine phosphatases (PTPs) have emerged as critical regulators of platelet function. Methods and Results This is the first report implicating the dual-specificity phosphatase 3 (DUSP3) in platelet signaling and thrombosis. This phosphatase is highly expressed in human and mouse platelets. Platelets from DUSP3-deficient mice displayed a selective impairment of aggregation and granule secretion mediated through the collagen receptor glycoprotein VI (GPVI) and the C-type lectin-like receptor 2 (CLEC-2). DUSP3-deficient mice were more resistant to collagen- and epinephrine-induced thromboembolism, compared to wild-type mice, and showed severely impaired thrombus formation upon ferric chloride-induced carotid artery injury. Intriguingly, bleeding times were not altered in DUSP3-deficient mice. At the molecular level, DUSP3 deficiency impaired Syk tyrosine phosphorylation, subsequently reducing phosphorylation of PLCγ2 and calcium fluxes. To investigate DUSP3 function in human platelets, a novel small-molecule inhibitor of DUSP3 was developed. This compound specifically inhibited collagen and CLEC-2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells. Conclusions DUSP3 plays a selective and essential role in collagen- and CLEC-2-mediated platelet activation and thrombus formation in vivo. Inhibition of DUSP3 may prove therapeutic for arterial thrombosis. This is the first time a PTP, implicated in platelet signaling, has been targeted with a small-molecule drug. [less ▲]

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See detailTypus melancholicus et recommandations pratiques
Ramackers, Amélia; Englebert, Jérôme ULg

Scientific conference (2015, February 16)

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See detailFermentation du kivuguto, lait traditionnel du Rwanda: mise au point d’un starter lactique
Karenzi, Eugène ULg

Doctoral thesis (2015)

Résumé Une recherche pour la production industrielle du kivuguto, lait caillé traditionnel du Rwanda a été entreprise par la sélection de micro-organismes responsables de la fermentation de ce lait ... [more ▼]

Résumé Une recherche pour la production industrielle du kivuguto, lait caillé traditionnel du Rwanda a été entreprise par la sélection de micro-organismes responsables de la fermentation de ce lait normalement produit artisanalement. Pour ce faire, il fallait une mise au point d’un starter lactique à partir des isolats issus des échantillons de lait artisanal kivuguto. Au terme de quatre échantillonnages, un dénombrement, un isolement et une purification ont abouti à conserver dans la Collection du CWBI 390 souches pures. Par des analyses phénotypiques (microscopiques, biochimiques), associées à des tests de résistance aux conditions extrêmes et à une analyse préliminaire des propriétés technologiques, 7 souches ont été pré-sélectionnées pour la poursuite du screening. Une caractérisation moléculaire par la méthode de 16S ADNr associé ou non à l’ITS 16S-23S ADNr a assimilé ces souches à deux Lactococcus lactis, deux Leuconostoc mesenteroides et trois Leuconostoc pseudomesenteroides. Des essais de formulation de laits fermentés par des mélanges de souches et leur conservation pendant 24 jours ont permis de formuler un lait fermenté semblable au lait artisanal kivuguto par l’association d’un Lactococcus lactis, d’un Leuconostoc mesenteroides et d’un Leuconostoc pseudomesenteroides. En effet, lors d’une analyse sensorielle discriminative, un jury de dégustation constitué de huit personnes est parvenu à identifier ce lait formulé parmi deux autres laits fermentés commercialisés aussi sur le marché à des différences significatives de p=0.05 dans une première série et p=0.01 dans une deuxième série. Des analyses technologiques proprement dites ont montré que ce lait formulé fermente après 14 heures avec une acidification de 73°D à pH4.6 et à 19°C, présente des caractéristiques d’un fluide visco-élastique. Son activité protéolytique est moyenne pour ne pas développer des peptides responsables de l’amertume en stockage. Son profil aromatique comporte cinq composés principaux 3-méthylbutan-1-ol, pentan-1-ol, acide acétique, furanméthan-2-ol et furan-2(5)H-one clairement identifiés par GC-MS. L’étude de la production et de la conservation de trois souches sélectionnées a montré une bonne stabilité sur trois mois à 4°C avec des viabilités cellulaires >90%, mais moins bonne à 20°C. [less ▲]

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See detailUltraviolet observations of the atmospheres of Venus and Mars and implications for their dynamics
Stiepen, Arnaud ULg

Scientific conference (2015, February 15)

Detailed reference viewed: 16 (2 ULg)