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See detailEen meertalige terminologie in de huisartsgeneeskunde - Nederlandse versie
Jamoulle, Marc ULg; Brouns, Johan; Steylaerts, Carl et al

Book published by Care Edition (2016)

Deze monografie geeft, onder de naam Een meertalige terminologie in huisartsgeneeskunde – neederlandse versie de lijst van de Q-Codes en de bijbehorende definities weer. Q-Codes, classificatie van niet ... [more ▼]

Deze monografie geeft, onder de naam Een meertalige terminologie in huisartsgeneeskunde – neederlandse versie de lijst van de Q-Codes en de bijbehorende definities weer. Q-Codes, classificatie van niet-klinische items van de husiartsgeneeskunde, ontwikkeldin een vorm die compatibel is met de ontwikkeling van een ontologie. Die ontologie kan u op de webserver www.hetop.eu van het laboratorium van bio-informatica van de Universiteit van Rouen (Frankrijk) vinden. Q-Codes hebben tot doel om het merendeel van de organisatie-concepten van de huisartsgeneeskunde te vertegenwoordigen. Q-codes vormen een aanvullend hoofdstuk van de Internationa Classification in Primary Care – second version (ICPC-2). Ze maken deel uit van het 3CGP-project (Core Content Classification in General Practice/Family Medicine). 3CGP combineert dus de ICPC-2 en de Q-Codes voor het indexeren van documenten (artikelen, abstracts van congressen). Eersts wordt de ontwikkeling uitgelegd van dit indexatie systeem, specifiek voor de huisartsgeneeskunde. Daarna worden de mogelijkheden van de webserver HeTOP gedetailleerd toegelicht. De lijst van Q-Codes wordt voorgesteld in tabelvorm, met vervolgens de gebruikte definites, gevolgd door een index. [less ▲]

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See detailDanh mục thuật ngữ đa ngôn ngữ về y học tổng quát và y học gia đình - Phiên bản tiếng Việt
Jamoulle, Marc ULg; Nguyễn Thùy, Châu; Trần Thị Hoa, Vi et al

Book published by CARE Editions - D/2016/7848/06 (2016)

Tài liệu này mang tên Từ điển thuật ngữ đa ngôn ngữ sử dụng trong Y học Tổng quát và Y học Gia đình - phiên bản tiếng Việt, được phiên dịch trực tiếp từ bản tiếng Pháp với sự đồng ý của tác giả Marc ... [more ▼]

Tài liệu này mang tên Từ điển thuật ngữ đa ngôn ngữ sử dụng trong Y học Tổng quát và Y học Gia đình - phiên bản tiếng Việt, được phiên dịch trực tiếp từ bản tiếng Pháp với sự đồng ý của tác giả Marc Jamoulle. Tài liệu tập trung giới thiệu chi tiết các thuật ngữ và định nghĩa đi kèm của bảng mã Q-codes. Đây là bảng danh mục các thuật ngữ đề cập các vấn đề không thuộc khía cạnh lâm sàng, được sử dụng trong chuyên ngành Y học Tổng quát và Y học Gia đình. Bộ danh mục này được nghiên cứu phát triển trên cơ sở sử dụng các công cụ khác nhau chuyền về thuật ngữ (ứng dụng chạy trên máy chủ tại www.hetop.eu của phòng thí nghiệm tin sinh học thuộc Đại học Rouen, nước Pháp). Mục đích của bảng mã Q-codes là nhằm giúp mô tả các phạm trù hệ thống mang tính đặc thù của chuyên ngành Y học gia đình. Q-codes đóng góp như một chương bổ sung thêm cho Bảng phân loại quốc tế dành cho chăm sóc ban đầu, phiên bản thứ 2 (ICPC-2). Q-codes cũng là một phần của đề án 3CGP (Core Content Classification in Primary Care – Classification du Contenu Essentiel des Soins Primaires). Trong đó, 3CGP kết hợp ICPC-2 và Q-codes nhằm giúp thiết lập chỉ mục qui chiếu cho các tài liệu. Trong tài liệu này, tác giả cũng giới thiệu khái quát về hệ thống lập chỉ mục chuyên biệt cho chuyên ngành y học gia đình. Một số thông tin về ứng dụng HeTOP dùng để xây dựng bộ danh mục này cũng sẽ được trình bày trong mục riêng. Phần cuối của tài liệu sẽ được sử dụng để giới thiệu chi tiết nội dung và các định nghĩa liên quan của bảng danh mục mã Q­ codes. [less ▲]

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See detailPulsations of the polar cusp aurora at Saturn
Palmaerts, Benjamin ULg; Radioti, Aikaterini ULg; Roussos, E. et al

in Journal of Geophysical Research. Space Physics (2016), 121

The magnetospheric cusp is a region connecting the interplanetary environment to the ionosphere and enabling solar wind particles to reach the ionosphere. We report the detection of several isolated high ... [more ▼]

The magnetospheric cusp is a region connecting the interplanetary environment to the ionosphere and enabling solar wind particles to reach the ionosphere. We report the detection of several isolated high-latitude auroral emissions with the Ultraviolet Imaging Spectrograph of the Cassini spacecraft. We suggest that these auroral spots, located in the dawn-to-noon sector and poleward of the main emission, are the ionospheric signatures of the magnetospheric cusp, in agreement with some previous observations with the Hubble Space Telescope. The high-latitude cusp auroral signature has been associated with high-latitude lobe reconnection in the presence of a southward interplanetary magnetic field. The occurrence rate of the polar cusp aurora suggests that lobe reconnection is frequent at Saturn. Several auroral imaging sequences reveal a quasiperiodic brightening of the polar cusp aurora with a period in the range of 60 to 70 min. Similar pulsations in the energetic electron fluxes and in the azimuthal component of the magnetic field are simultaneously observed by Cassini instruments, suggesting the presence of field-aligned currents. Pulsed dayside magnetopause reconnection is a likely common triggering process for the cusp auroral brightenings at Saturn and the quasiperiodic pulsations in the high-latitude energetic electron fluxes. [less ▲]

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See detailL’« ordre géométrique » et le dispositif argumentatif des Méditations métaphysiques de René Descartes
Dubouclez, Olivier ULg

in Revue d'Histoire des Sciences (2016), 69(2), 255-278

Summary : Although nothing shows at first sight that the Metaphysical meditations are built in accordance with a mathematical model, Des- cartes’ claim to have followed the « mos geometricus » invites us ... [more ▼]

Summary : Although nothing shows at first sight that the Metaphysical meditations are built in accordance with a mathematical model, Des- cartes’ claim to have followed the « mos geometricus » invites us to pass over that first impression and to reconsider the Cartesian art of medita- tion. Descartes’ main letters of 1640 (where he describes and also criti- cizes his metaphysical method) along with the last pages of the Second replies of 1641 reveal indeed a mathematical pattern of argumentation based on the classical notion of geometrical analysis. But, if analysis plays an active role in the realization of the « order of reasons » within the context of hyperbolic doubt, its is deeply transformed by Descartes and amounts to a combination of two argumentative tools, namely sup- position and enumeration, which are common to geometry and meta- physics. This article suggests in which sense the very method of Cartesian metaphysics, while not following a strictly linear « chain of reasons », can be genuinely said geometrical. [less ▲]

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See detailCross-cultural adaptation and validation of the Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire on lateral elbow tendinopathy for French-speaking patients
Kaux, Jean-François ULg; DELVAUX, François ULg; SCHAUS, Jean ULg et al

in Journal of Hand Therapy (2016), 29(4), 496-504

Background: The lateral elbow tendinopathy is a common injury in tennis players and physical workers. The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire was specifically designed to measure ... [more ▼]

Background: The lateral elbow tendinopathy is a common injury in tennis players and physical workers. The Patient-Rated Tennis Elbow Evaluation (PRTEE) questionnaire was specifically designed to measure pain and functional limitations in patients with lateral epicondylitis (tennis elbow). First developed in English, this questionnaire has since been translated into several languages. Objectives: The aims of the study were to translate and cross-culturally adapt the PRTEE questionnaire into French and to evaluate the reliability and validity of this translated version of the questionnaire (PRTEE-F). Methods: The PRTEE was translated and cross-culturally adapted into French according to international guidelines. To assess the reliability and validity of the PRTEE-F, 115 participants were asked twice to fill in the PRTEE-F, and once the Disabilities of Arm, Shoulder and Hand questionnaire (DASH) and the Short Form Health Survey (SF-36). Internal consistency (using Cronbach’s alpha), test-retest reliability (using intra-class correlation coefficient (ICC), Standard Error of Measurement (SEM) and Minimal Detectable Change (MDC)), and convergent and divergent validity (using the Spearman’s correlation coefficients respectively with the DASH and with some sub scales of the SF-36) were assessed. Results: The PRTEE was translated into French without any problems. PRTEE-F showed a good test-retest reliability for the overall score (ICC 0.86) and for each item (ICC 0.8-0.96) and a high internal consistency (Cronbach’s alpha = 0.98). The correlation analyses revealed high correlation coefficients between PRTEE-F and DASH (convergent validity) and, as expected, a low or moderate correlation with the divergent subscales of the SF-36 (discriminant validity). There was no floor or ceiling effect. Conclusions: The PRTEE questionnaire was successfully cross-culturally adapted into French. The PRTEE-F is reliable and valid for evaluating French-speaking patients with lateral elbow tendinopathy. [less ▲]

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See detailFondations, philanthropie et mécénat
Vandenbulke, Antoine ULg

in Revue Pratique des Sociétés - Tijdschrift voor Rechtspersoon en Vennootschap (2016), 7

The aim of this paper is to provide an in-depth presentation of the legal aspects of foundations in its philanthropic function. The study introduces historically this legal structure and then exposes its ... [more ▼]

The aim of this paper is to provide an in-depth presentation of the legal aspects of foundations in its philanthropic function. The study introduces historically this legal structure and then exposes its main aspects in positive Belgian law (constitution, increase of the assets, taxation and dissolution). It concludes with a comparison with French law. [less ▲]

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See detailInterviews sur la rénovation du stock bâti en Belgique
Ruellan, Guirec ULg

Report (2016)

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See detailMultidisciplinary management of breast cancer
Leclerc, Anne-France ULg; JERUSALEM, Guy ULg; DEVOS, Martine ULg et al

in Archives of Public Health (2016), 74

Breast cancer, with an increasing incidence, is the most frequently diagnosed cancer in women worldwide. The treatments proposed, generally a combination of surgery, radiotherapy, chemotherapy, endocrine ... [more ▼]

Breast cancer, with an increasing incidence, is the most frequently diagnosed cancer in women worldwide. The treatments proposed, generally a combination of surgery, radiotherapy, chemotherapy, endocrine therapy and / or targeted therapy, are constantly improving, allowing a reduction in the mortality rate, but they are still causing many side effects, not only early but also late, which leads us to consider the post-cancer period as a chronic condition. Side effects, reviewed in this commentary, may affect physical functions, psychological status, social situation, body composition, well-being and quality of life of the patient. In view of the extent of these areas in which side effects of breast cancer and of its treatments can be found, the supportive care offered at the end of treatment need to be multidisciplinary. Different supportive care interventions may be proposed to the patients such as psychological and behavioral interventions, complementary therapies, diet interventions, physical activity/rehabilitation or also physiotherapy interventions for example, all having shown some beneficial effects in the literature. The benefits of these supportive care interventions are thereby already established and they are described in this article, but others studies will be needed to clearly define indications and most optimal modalities of application to reduce side effects and improve quality of life of patients. [less ▲]

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See detailEnjeux méthodologiques dans un contexte de rémission en oncologie pédiatrique: triangulation entre le médecin, sa famille et le patient
Vander Haegen, Marie ULg; Etienne, Anne-Marie ULg

in De l'expertise scientifique à l'expertise profane: Postures, enjeux et méthodes dans le champs de la psychologie de la santé (2016, December)

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See detailThe added value of new GNSS for ionosphere monitoring
Warnant, René ULg; Deprez, Cécile ULg

in Proceedings of Navitec 2016 (2016, December)

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See detailNEW INJECTABLE LIPOSOME AND DRUG-IN-CYCLODEXTRIN-IN LIPOSOME SYSTEMS ENCAPSULATING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES
Palazzo, Claudio ULg; Laloy, Julie; Delvigne, Anne-Sophie et al

Poster (2016, December)

Purpose: In 2010, almost 15 million of babies in the world are prematurely borned, 11.1 % of the total amount of alive children. Despite the better neonatology techniques, the number of preterm babies ... [more ▼]

Purpose: In 2010, almost 15 million of babies in the world are prematurely borned, 11.1 % of the total amount of alive children. Despite the better neonatology techniques, the number of preterm babies with motor, vision, hearing or mental deficiencies is still constant along the last twenty years. Moreover, no efficacy treatment is available to the present day. The estetrol (E4) has an important role in the brain development and protection. The aim of this study is to develop new injectable liposome and drug-in-cyclodextrin-in-liposome (DCL) formulations, encapsulating E4 in order to enhance its crossing through the blood-brain barrier (BBB). Methods: Cyclodextrins (CD) were used to increase E4 aqueous solubility. Liposome and DCL (E4-CD complex) formulations were prepared by thin-film hydration technique. The formulations were physicochemical characterized. LDH and MTS tests on endothelial, neuronal and BBB model cells were performed in vitro on the liposome formulation. Hemocompatibility of the formulations was evaluated on red blood cells, platelet aggregation and coagulation. BBB passage tests were performed using human BBB cell line (hCMEC/D3). Results: E4-CD complexes proportionally increased the solubility of the hormone. Liposomes and DCL encapsulating E4 were prepared. All the formulations had average particle size below 150 nm, polydispersity index below 0.10 and ζ potential around + 30 mV. The encapsulation efficacy for liposomes was between 3% and 10% while those of DCL are between 15% and 35%. Moreover, the formulations are capable to release 80 % (liposome) and 90 % (DCL) of encapsulated E4 after 3 h at 37°C. The effect of liposome and DCL formulations on cell viability and integrity was evaluated. The results showed no toxic effects on all the tested cell lines. Hemocompatibility tests showed no hemolysis, platelet aggregation or effects on coagulation, confirming the possibility of the formulations to be intravenously administrated. BBB passage tests highlighted the capability of the formulations to pass the BBB and reach the brain. Conclusions: New non-toxic, hemocompatible liposome and DCL formulations encapsulating E4 were prepared. The formulations are promising drug delivery system to target estrogens to the brain, due to their physiochemical characteristics. [less ▲]

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See detailEvolution récente des surface forestières et de la régénération des coupes rases en Wallonie
Latte, Nicolas ULg; Perin, Jérôme ULg; Lejeune, Philippe ULg

in FORÊT.NATURE (2016), 141

Une gestion réfléchie de la ressource forestière à l’échelle d’une région, telle que la Wallonie, nécessite de connaitre son état et de prédire son devenir. Pour y parvenir, nous proposons une méthode ... [more ▼]

Une gestion réfléchie de la ressource forestière à l’échelle d’une région, telle que la Wallonie, nécessite de connaitre son état et de prédire son devenir. Pour y parvenir, nous proposons une méthode relativement simple, combinant trois sources de données : l’inventaire forestier régional, la photo-interprétation d’orthoimages et une enquête de terrain, ayant comme finalité de décrire finement l’évolution des surfaces forestières, les peuplements mis à blanc et la régénération des coupes rases. [less ▲]

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See detailPractical aspects of gene regulatory inference via conditional inference forests from expression data
Bessonov, Kyrylo ULg; Van Steen, Kristel ULg

in Genetic Epidemiology (2016)

Gene regulatory network (GRN) inference is an active area of research that facilitates understanding the complex interplays between biological molecules. We propose a novel framework to create such GRNs ... [more ▼]

Gene regulatory network (GRN) inference is an active area of research that facilitates understanding the complex interplays between biological molecules. We propose a novel framework to create such GRNs, based on Conditional Inference Forests (CIFs) as proposed by Strobl et al. Our framework consists of using ensembles of Conditional Inference Trees (CITs) and selecting an appropriate aggregation scheme for variant selection prior to network construction. We show on synthetic microarray data that taking the original implementation of CIFs with conditional permutation scheme (CIFcond) may lead to improved performance compared to Breiman's implementation of Random Forests (RF). Among all newly introduced CIF-based methods and five network scenarios obtained from the DREAM4 challenge, CIFcond performed best. Networks derived from well-tuned CIFs, obtained by simply averaging P-values over tree ensembles (CIFmean) are particularly attractive, because they combine adequate performance with computational efficiency. Moreover, thresholds for variable selection are based on significance levels for P-values and, hence, do not need to be tuned. From a practical point of view, our extensive simulations show the potential advantages of CIFmean-based methods. Although more work is needed to improve on speed, especially when fully exploiting the advantages of CITs in the context of heterogeneous and correlated data, we have shown that CIF methodology can be flexibly inserted in a framework to infer biological interactions. Notably, we confirmed biologically relevant interaction between IL2RA and FOXP1, linked to the IL-2 signaling pathway and to type 1 diabetes. [less ▲]

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See detailDonner son corps à la science. Progrès de la Médecine et apprentissage des médecins.
Bonnet, Pierre ULg

Learning material (2016)

Cours du cycle de l'Espace Universitaire de Liège 2016-17, Module Sciences et Avenir, cycle 1

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See detailGuide du chercheur américaniste à Brown University, Providence, Rhode Island, USA
Dauphin, Jean-Christophe ULg

in Nuevo Mundo Nuevos Mundos (2016)

Guide pratique destiné aux chercheurs américanistes.

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See detailThe Martian diffuse aurora: Monte Carlo simulations and comparison with IUVS-MAVEN observations
Gérard, Jean-Claude ULg; Soret, Lauriane ULg; Schneider, N. et al

Conference (2016, December)

A new type of Martian aurora, characterized by an extended spatial distribution, an altitude lower than the discrete aurora and electron precipitation up to 200 keV has been observed following solar ... [more ▼]

A new type of Martian aurora, characterized by an extended spatial distribution, an altitude lower than the discrete aurora and electron precipitation up to 200 keV has been observed following solar activity on several occasions with the IUVS on board the MAVEN spacecraft. We describe the results of Monte Carlo simulations of the production of several ultraviolet and visible auroral emissions for initial electron energies from 0.1 to 200 keV. These include the CO2+ ultraviolet doublet (UVD) at 288.3 and 289.6 nm and the Fox–Duffendack–Barker (FDB) bands, CO Cameron and Fourth Positive bands, OI 130.4 and 297.2 nm and CI 156.1 nm and 165.7 nm multiplets. We calculate the nadir and limb intensities of several of these emissions for a unit precipitated energy flux. Our results indicate that electrons in the range 100-200 keV produce maximum CO2+ UVD emission near 75 km. We combine SWEA and SEP electron energy spectra measured during diffuse aurora to calculate the volume emission rates and compare with IUVS observations of the emission limb profiles. The strongest predicted emissions are the CO2+ FDB, UVD and the CO Cameron bands. The metastable a 3Π state which radiates the Cameron bands is deactivated by collisions below ~110 km. As a consequence, we show that the CO2+ UVD to the Cameron bands ratio increases at low altitude in the energetic diffuse aurora. [less ▲]

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See detailA Rhynie Chert plant out of the Rhynie Chert
Cascales-Miñana, Borja ULg; Gerrienne, Philippe ULg

Conference (2016, December)

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See detailThe "graptolite hypothesis" or how to turn a palaeobotanical evidence into a scientific puzzle
Gerrienne, Philippe ULg; Tinn, Oive; Versteegh, Gerard et al

Conference (2016, December)

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See detailRelationships between environmental parameters and the microbenthic loop of Posidonia oceanica meadows at small spatial scale
Pete, Dorothée ULg; Alvera Azcarate, Aida ULg; Gobert, Sylvie ULg

in Zoology 2016: 23rd Congress of Zoology (2016, December)

In these times of global change, understanding how carbon flows through ecosystems is of primary importance. In coastal Mediterranean regions, Posidonia oceanica meadows produce and store a lot of carbon ... [more ▼]

In these times of global change, understanding how carbon flows through ecosystems is of primary importance. In coastal Mediterranean regions, Posidonia oceanica meadows produce and store a lot of carbon, but most of it is described as refractory. As a step in the understanding of how organic matter degradation/storage happens in this ecosystem, this study focus on small scale relationships between the microbenthic loop (organic matter, microphytobenthos, bacteria and meiofauna) and environmental parameters (grain size, P. oceanica density, vegetal fibre biomass, pore water nutrient content, sediment total carbon (TC), organic carbon (TOC), nitrogen (TN) and phosphorous (TP) contents, phaeopigments and bacterial production (FDC)). Thus, a 1.25 m x 1.25 m frame was put in a pristine P. oceanica meadow and twelve points were randomly sampled in May 2008 for all the studied parameters. At such a small scale, every component of the microbenthic loop presented a heterogeneity, which was the highest for the microphytobenthos biomass and the lowest for total meiofauna abundance (TMA). No relationship was found between the components of the microbenthic loop but the abundances of Turbellaria and Ciliophora were correlated with total organic matter in the sediment (TOM). None of the environmental parameter was linked with the microphytobenthos biomass, suggesting that the high spatial variability observed did not depend on the measured parameters. Relationships were found between TOM and ammonium, total bacteria abundance and biomass (TBA and TBB) and sediment phaeopigments, TMA and TC, TN and TP. TBB variability was however explained by a combination of FDC and nutrient contents in pore water and sediment. Taking the microbenthic loop as a whole, pore water ammonium and nitrites + nitrates, FDC and phaeopigments were able to explain the observed variability. So, at small scale the variability in the microbenthic loop of a P. oceanica meadow is related with parameters linked with degradation processes and bacteria activities (phaeopigments, FDC, ammonium, nitrites + nitrates), except for meiofauna, which is related with the nutrient content of the sediment, especially TC. Those results underline the importance of the relationship between the microbenthic loop and degradation processes, even at a small scale. [less ▲]

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