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See detailThe course of anaemia in children and adolescents with Crohn's disease included in a prospective registry.
Van Biervliet, Stephanie; Smets, Francoise; Hofmann, Ilse et al

in International journal of colorectal disease (2015), 30(1), 51-6

AIM: The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). METHODS: The BELCRO registry ... [more ▼]

AIM: The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). METHODS: The BELCRO registry (inclusion May 2008-April 2010), describing current clinical treatment practice of children diagnosed with CD, provided data on age, height, body mass index (BMI), paediatric Crohn's disease activity index (PCDAI), therapy and haemoglobin (Hb) at diagnosis 12 and 24 months follow-up. Anaemia was defined as Hb < -2 sd, while severe anaemia was defined as Hb < -4 sd. Patients were classified as child </=13 and adolescent >13 years of age. RESULT: Ninety-six were included, 13 dropped out due to insufficient Hb data (37 females/46 males; median age 13.3 years, range 2.2-17.8 years). At diagnosis, the median Hb sd was -2.66 (-8.4; 1.07) and was correlated with the PCDAI (p = 0.013). At diagnosis, 51/83 (61 %) were anaemic and all had active disease. Hb z-score significantly improved (p < 0.0001) but 26/68 (38 %) remained anaemic at 12 months and 29/76 (38 %) at 24 months of follow-up. The correlation to the PCDAI disappeared. At 24 months, children were more likely to be anaemic. There was no difference in iron dose nor duration of iron supplements between children and adolescents. Iron treatment was more readily given to patients presenting with anaemia. Hb did not differ between patients with (n = 28) or without iron supplements. Half of the patients with persisting anaemia were given iron supplements, of which, only three were given intravenously. CONCLUSION: Anaemia remains an important extra-intestinal manifestation of CD in children. Physicians, lacking optimal treatment strategies, undertreat their patients. [less ▲]

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See detailDevelopment of the lemann index to assess digestive tract damage in patients with Crohn's disease.
Pariente, Benjamin; Mary, Jean-Yves; Danese, Silvio et al

in Gastroenterology (2015), 148(1), 52-633

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for ... [more ▼]

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lemann Index and assessed its ability to measure cumulative structural bowel damage in patients with Crohn's disease (CD). METHODS: We performed a prospective, multicenter, international, cross-sectional study of patients with CD evaluated at 24 centers in 15 countries. Inclusions were stratified based on CD location and duration. All patients underwent clinical examination and abdominal magnetic resonance imaging analyses. Upper endoscopy, colonoscopy, and pelvic magnetic resonance imaging analyses were performed according to suspected disease locations. The digestive tract was divided into 4 organs and subsequently into segments. For each segment, investigators collected information on previous operations, predefined strictures, and/or penetrating lesions of maximal severity (grades 1-3), and then provided damage evaluations ranging from 0.0 (no lesion) to 10.0 (complete resection). Overall level of organ damage was calculated from the average of segmental damage. Investigators provided a global damage evaluation (from 0.0 to 10.0) using calculated organ damage evaluations. Predicted organ indexes and Lemann Index were constructed using a multiple linear mixed model, showing the best fit with investigator organ and global damage evaluations, respectively. An internal cross-validation was performed using bootstrap methods. RESULTS: Data from 138 patients (24, 115, 92, and 59 with upper tract, small bowel, colon/rectum, and anus CD location, respectively) were analyzed. According to validation, the unbiased correlation coefficients between predicted indexes and investigator damage evaluations were 0.85, 0.98, 0.90, 0.82 for upper tract, small bowel, colon/rectum, anus, respectively, and 0.84 overall. CONCLUSIONS: In a cross-sectional study, we assessed the ability of the Lemann Index to measure cumulative structural bowel damage in patients with CD. Provided further successful validation and good sensitivity to change, the index should be used to evaluate progression of CD and efficacy of treatment. [less ▲]

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See detailTransposability of pedotransfer functions for estimating water retention of Algerian soils
Touil, Sami; Degré, Aurore ULg; Chabaca, Mohamed Nacer

in Desalination and Water Treatment (2015)

Testing the efficiency of a pedotransfer function (PTF) outside of its development data-set is one of the best ways for assessing its robustness. An important question which remains unanswered is how ... [more ▼]

Testing the efficiency of a pedotransfer function (PTF) outside of its development data-set is one of the best ways for assessing its robustness. An important question which remains unanswered is how transposable are PTFs to other agropedoclimatic contexts? Models developed and validated in a particular pedoclimatic context have been relatively little tested in other contexts. Particularly, no studies have been conducted until now to evaluate the PTFs for Algerian soils. In this study, eight (8) PTFs most frequently cited were considered. We used them to evaluate soil water retention at field capacity (FC) and wilting point (WP) on a set of 134 samples collected in the low Cheliff. The calculated Akaike information criterion and root mean square errors values showed that the Rawls, and Ghorbani Dashtaki et Homaee type 1 models were the best in estimation of soil water retention at FC (–709.795, 0.070 cm3 cm−3) and WP (–733.480, 0.064 cm3 cm−3). The poorer performances were presented by the PTFs developed on soils from Europe or United States where the organic matter values were much higher than the Algerian soils. However, the transposability of the PTFs formed from data spread from a wider area, produce more accurate predictions than those built from local data. [less ▲]

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See detailA Typology of Customer-Perceived Bad News in Service Encounters
Delcourt, Cécile ULg; Gremler, Dwayne; van Riel, Allard et al

in The 14th International Research Symposium on Service Excellence in Management (2015)

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Lebrun, Pierre ULg; Michiels, Jean-François et al

in Journal of Biopharmaceutical Statistics (2015), 25

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedures that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling, and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure design space, and from it, control strategy can be set. [less ▲]

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See detailInfluence of viscosity on Liquid Flow Inside Structured Packings
Bradttmöller, Christian; Janzen, Anna; Crine, Michel ULg et al

in Industrial & Engineering Chemistry Research (2015), 54

In this study, X-ray computer tomography and light-induced fluorescence were applied to investigate the morphology of liquid flow inside structured packings. Fluid dynamic parameters such as liquid holdup ... [more ▼]

In this study, X-ray computer tomography and light-induced fluorescence were applied to investigate the morphology of liquid flow inside structured packings. Fluid dynamic parameters such as liquid holdup and wetted surface were determined to study the effect of the variation of viscosity and liquid load. Flow patterns inside the packing were identified and categorized. Liquid film thickness and its distribution were analyzed on single sheets. For both methods, the measured holdup values are in good agreement, despite differences in the techniques of measurement. For the flow patterns and their relative contribution, as well as mean liquid film thickness, a strong dependency on the varied parameters was found. Furthermore, the density function of film thickness distribution changed characteristically with liquid load and viscosity. The complementary use of tomography and optical assessment allowed an improved insight into flow phenomena and the observed interdependency of physical, geometric, and operational parameters. [less ▲]

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See detailA quality by design approach for longitudinal quality attributes
Lebrun, Pierre ULg; Giacoletti, Katherine; Scherder, Tara et al

in Journal of Biopharmaceutical Statistics (2015), 25

The concept of quality by design (QbD) as published in ICH-Q8 is currently one of the most recurrent topics in the pharmaceutical literature. This guideline recommends the use of information and prior ... [more ▼]

The concept of quality by design (QbD) as published in ICH-Q8 is currently one of the most recurrent topics in the pharmaceutical literature. This guideline recommends the use of information and prior knowledge gathered during pharmaceutical development studies to provide a scientific rationale for the manufacturing process of a product and provide guarantee of future quality. This poses several challenges from a statistical standpoint and requires a shift in paradigm from traditional statistical practices. First, to provide “assurance of quality” of future lots implies the need to make predictions regarding the quality given past evidence and data. Second, the quality attributes described in the Q8 guidelines are not always a set of unique, independent measurements. In many cases, these criteria are com- plicated longitudinal data with successive acceptance criteria over a defined period of time. A common example is a dissolution profile for a modified or extended-release solid dosage form that must fall within acceptance limits at several time points. A Bayesian approach for longitudinal data obtained in various conditions of a design of experiment is provided to elegantly address the ICH-Q8 recommendation to provide assurance of quality and derive a scientifically sound design space. [less ▲]

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See detailPour enchanter vos clients ? Enchantez et engagez d’abord vos collaborateurs !
Delcourt, Cécile ULg

Article for general public (2015)

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See detailLe genre Guibourtia Benn., un taxon à haute valeur commerciale et sociétale (synthèse bibliographique)
Tosso, Dji-ndé Félicien ULg; Daïnou, Kasso ULg; Hardy, J. Olivier et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1),

Known as a genus of great socio-cultural and economical importance, Guibourtia Benn. includes morphologically very similar multipurpose sister species, found in various habitats with different climate and ... [more ▼]

Known as a genus of great socio-cultural and economical importance, Guibourtia Benn. includes morphologically very similar multipurpose sister species, found in various habitats with different climate and soil conditions. In many places, Guibourtia is subject to local overexploitation by forest companies and local communities. As the population density of Guibourtia species is generally very low, it may be necessary to conduct scientific investigations that will provide valuable information for the management of the populations concerned. This paper is based on an extensive literature review and summarizes the available information on the genus Guibourtia, in terms of botany, ecology, genetics, forestry and ethnobotany. Our review provided evidence that, to date, ecological and silvicultural knowledge regarding Guibourtia species is lacking and that it is very difficult to morphologically differentiate very similar sister species. In addition, we provide a new determination key for the genus Guibourtia. Based on the available information, it is difficult to assess the conservation status of these taxa. Further investigations are needed to suggest appropriate management strategies for Guibourtia. Moreover, species diversity within this genus and its distribution in various tropical biomes make it an excellent biological model for understanding the historical, biological and environmental mechanisms that explain the diversity of tropical moist forests. [less ▲]

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See detailExtracellular peptidase hunting for improvement of protein production in plant cells and roots
Lallemand, Jérôme ULg; Bouché, Frédéric ULg; Desiron, Carole et al

in Frontiers in Plant Science (2015), 6(37),

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now ... [more ▼]

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve plant hosts and strategies for biopharming. Targeting recombinant proteins toward the extracellular space offers several advantages in terms of protein folding and purification, but degradation events are observed, due to endogenous peptidases. This paper focuses on the analysis of extracellular proteolytic activities in two production systems: cell cultures and root-secretion (rhizosecretion), in Arabidopsis thaliana and Nicotiana tabacum. Proteolytic activities of extracellular proteomes (secretomes) were evaluated in vitro against two substrate proteins: bovine serum albumin (BSA) and human serum immunoglobulins G (hIgGs). Both targets were found to be degraded by the secretomes, BSA being more prone to proteolysis than hIgGs. The analysis of the proteolysis pH-dependence showed that target degradation was mainly dependent upon the production system: rhizosecretomes contained more peptidase activity than extracellular medium of cell suspensions, whereas variations due to plant species were smaller. Using class-specific peptidase inhibitors, serine and metallopeptidases were found to be responsible for degradation of both substrates. An in-depth in silico analysis of genomic and transcriptomic data from Arabidopsis was then performed and led to the identification of a limited number of serine and metallo-peptidases that are consistently expressed in both production systems. These peptidases should be prime candidates for further improvement of plant hosts by targeted silencing. [less ▲]

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See detailLutter contre l'éjaculation précoce
Kempeneers, Philippe ULg; Bauwens, Sabrina; ANDRIANNE, Robert ULg

Book published by De Boeck-Solal (2015)

Aujourd’hui, environ un homme sur cinq se plaint d’éjaculer trop rapidement. Face à ce constat, les auteurs ont rédigé un guide pratique, le premier publié en langue française dont l’efficacité à été ... [more ▼]

Aujourd’hui, environ un homme sur cinq se plaint d’éjaculer trop rapidement. Face à ce constat, les auteurs ont rédigé un guide pratique, le premier publié en langue française dont l’efficacité à été démontrée par des études cliniques. Cet ouvrage peut être assimilé à un véritable traitement car il offre à tous les hommes et à tous les couples confrontés à ce problème, des information et des conseils afin de tenter d’y remédier. Ce guide intéressera également les intervenants en santé soucieux d’accompagner leurs patients ou clients confrontés à une éjaculation précoce (médecins, psychologues, sexologues …). Ils y trouveront un modèle et des lignes directrices thérapeutiques aisément applicables en première intention. [less ▲]

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See detailFunctional adaptations of the bacterial chaperone trigger factor to extreme environmental temperatures
Godin-Roulling, Amandine ULg; Schmidpeter, P.A.M.; Schmid, F.X. et al

in Environmental Microbiology (2015)

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See detail¿Quién mató a Rosario Tijeras? Narco y culpa.
Vanden Berghe, Kristine ULg

in Bulletin of Spanish Studies (2015), 92(2), 2-19

The novel Rosario Tijeras (Jorge Franco Ramos, 1999) is interpreted here from the perspective of the literary genre of the whodunnit. More particularly, the analysis investigates who is responsible for ... [more ▼]

The novel Rosario Tijeras (Jorge Franco Ramos, 1999) is interpreted here from the perspective of the literary genre of the whodunnit. More particularly, the analysis investigates who is responsible for the murder of the female assassin. Taking into account the serious psychological instability of the narrator and the violations of the maxims of communicative cooperation, it is argued that he is an unreliable narrator. Such a reading of the novel as a detective story told by an unreliable narrator reveals a number of clues as to who murdered Rosario Tijeras. It also paves the way towards a new interpretation of the novel: this article argues that there is a parallelism between Franco Ramos’ novel and La virgen de los Sicarios (1994) by Fernando Vallejo: in both novels the issues of violence and guilt in societies dominated by drug trafficking are treated in a similar way. [less ▲]

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See detailVISMODEGIB ET CARCINOMES BASOCELLULAIRES LOCALEMENT AVANCES
LEBAS, Eglantine ULg; RORIVE, Andrée ULg; EL HAYDERI, Lara ULg et al

in Revue Médicale de Liège (2015)

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in ... [more ▼]

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in the pathogenesis of basal cell carcinoma. Vismodegib is a selective inhibitor of this pathway and may be administered orally. Its main indication is locally advanced basal cell carcinoma, when other therapeutic options have failed or are contra-indicated. Vismodegib can also be used as prophylactic therapy in the Gorlin syndrome or basal cell nevomatosis. Its principal adverse effects are muscle spasms, alopecia and altered taste. They are frequent, but often moderate in intensity; they sometimes restrict continuation of treatment. Two clinical cases are presented, relating the efficacity and tolerance of this new therapeutic option. [less ▲]

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See detailTHERAPY OF ENDOCRINE DISEASE: Outcomes in patients with Cushing's disease undergoing transsphenoidal surgery: systematic review assessing criteria used to define remission and recurrence.
Petersenn, Stephan; Beckers, Albert ULg; Ferone, Diego et al

in European journal of endocrinology / European Federation of Endocrine Societies (2015)

Objective: A number of factors can influence the reported outcomes of transsphenoidal surgery (TSS) for Cushing's disease - including different remission and recurrence criteria, for which there is no ... [more ▼]

Objective: A number of factors can influence the reported outcomes of transsphenoidal surgery (TSS) for Cushing's disease - including different remission and recurrence criteria, for which there is no consensus. Therefore, a comparative analysis of the best treatment options and patient management strategies is difficult. In this review, we investigated the clinical outcomes of initial TSS in patients with Cushing's disease based on definitions of and assessments for remission and recurrence. Methods: We systematically searched PubMed and identified 44 studies with clear definitions of remission and recurrence. When data were available, additional analyses by time of remission, tumour size, duration of follow-up, surgical experience, year of study publication, and adverse events related to surgery were performed. Results: Of the 44 articles selected, only one reported endoscopic TSS. Data from a total of 6,400 patients who received microscopic TSS were extracted and analysed. A variety of definitions of remission and recurrence of Cushing's disease after initial microscopic TSS was used, giving broad ranges of remission (42.0-96.6%; median, 77.9%) and recurrence (3.1-47.4%; median, 11.5%). Better remission and recurrence outcomes were achieved for micro- versus macroadenomas; however, no correlations were found with other parameters, other than improved safety with longer surgical experience. Conclusions: The variety of methodologies used in clinical evaluation of TSS for Cushing's disease strongly support the call for standardization and optimization of studies to inform clinical practice and maximize patient outcomes. Clinically significant rates of failure of initial TSS highlight the need for effective second-line treatments. [less ▲]

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See detailBeyond the Experience: Detection of Metamemorial Regularities
Geurten, Marie ULg; Willems, Sylvie ULg; Meulemans, Thierry ULg

in Consciousness & Cognition (2015), 33

We examined the mechanisms involved in the development of the easily learned, easily remembered (ELER) heuristic in three groups of young children (4–5 years, 6–7 years, and 8–9 years). A trial-to ... [more ▼]

We examined the mechanisms involved in the development of the easily learned, easily remembered (ELER) heuristic in three groups of young children (4–5 years, 6–7 years, and 8–9 years). A trial-to-acquisition procedure was used to evaluate how much these children’s judgment of learning depended on the ELER heuristic. Moreover, a new experimental paradigm, composed of six phases—a pretest, four training phases, and a posttest—was employed to implicitly influence the validity of the ELER association that underlies this metacognitive rule. Results revealed that the ELER heuristic develops early (4–5 years), but its use is reduced after implicit training. Furthermore, executive monitoring was found to account for the smaller changes observed in older children (8–9 years) after training. From a developmental perspective, these findings present a coherent picture of children’s learning of metacognitive heuristics, wherein early automatic and implicit learning is later followed by effortful control. [less ▲]

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See detailLegal mobilization in comparative perspective: workplace discrimination and access to domestic labor court in Sweden and Belgium
Lejeune, Aude ULg

Conference (2015)

Some scholarly works on legal mobilization have highlighted the diffusion of litigious policies to address social problems in Europe, considering that a rights’ revolution was underway. While many of ... [more ▼]

Some scholarly works on legal mobilization have highlighted the diffusion of litigious policies to address social problems in Europe, considering that a rights’ revolution was underway. While many of these studies have examined the diffusion of litigious policy at European level or in the United Kingdom, I suggest paying attention to Belgium and Sweden, two countries that have been under-examined by the socio-legal literature. Focusing on the implementation of anti- discrimination policy and norms, this paper explores the litigious activity of national equality agencies in the domestic labor court. The analysis of organizations’ litigious policy in Continental Europe invites to integrate another variable to the analysis of the structure of legal opportunities: the relationship between the State and interests groups. I suggest here that labor unions shape the access to labor courts by equality agencies in each national setting. This contribution aims to highlight equality agencies’ structure and agency within different labor contexts, current anti- discrimination policies and legal culture. It relies on open-ended interviews conducted with lawyers from equality agencies and labor unions in Belgium and Sweden. More broadly, this contribution examines the processes of policy implementation of European directive within member states. [less ▲]

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See detailFamilial Isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene
Daly, Adrian ULg; Beckers, Albert ULg

in Endocrinology & Metabolism Clinics of North America (2015), 44

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See detailLa copie d’expression écrite en langue étrangère : un support équitable ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Spirale (2015), 55

Summative writing assessment is an evaluative practice that aims, at least theoretically, to inform each student about his performance in that skill at a given time, and to help him to understand his ... [more ▼]

Summative writing assessment is an evaluative practice that aims, at least theoretically, to inform each student about his performance in that skill at a given time, and to help him to understand his errors so that he can make progress in his learning. In this article, we analyse summative writing assessment through various prisms. At the macro level, we discuss the reforms of the education system pertaining to assessment ; at the meso level, we target the assessment tools offered by the same education system, as well as the attention that may or may not be paid to remediation ; at the micro level, we deal with the issue of corrective feedback which students receive on their written production. By crossing these different sources (legal provisions, interviews, surveys, analysis of students’ annotated written production, etc.), we conclude that this practice may present major risks of inequality. [less ▲]

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See detailIdentiteiten, staatshervorming en stemgedrag
Deschouwer, Kris; De Winter, Lieven; Reuchamps, Min et al

in Deschouwer, Kris; Delwit, Pascal; Hooghe, Marc (Eds.) et al Het cryptogram van de kiezer. Het stemgedrag en de stemmotivaties op 25 mei 2014 (2015)

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