Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailSoluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus
Alzamel, Nidal ULg; Bayrou, Calixte ULg; Decreux, Annabelle et al

in Comparative Immunology, Microbiology and Infectious Diseases (2016), 49

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides ... [more ▼]

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides, 66EQIV69 and 82GQVLAL87, located on antiparallel beta sheets in the most distal complement control protein module (CCP1), provide the attachment platform. In the present study, we reveal new CD46-encoding transcripts that are predicted to encode CCP1-containing soluble forms. Further, we show that the serum of most adult cattle contains soluble CD46 (sCD46) and that a recombinant soluble isoform neutralizes BVDV infectivity in an in vitro assay. We have then established an ELISA for determination of plasma sCD46 in a large cohort of animals. Overall, serum sCD46 amounts to 8 ± 18 ng/mL (mean ± SD, n = 440), with a IC [95-105] ranging from 6,4 to 9,8 ng/mL and extreme values between 0 and 178 ng/mL. We found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood. We also detected high- and low-sCD46 performers and show that this phenotype does not depend of environment. As modern rearing techniques make it possible to disseminate genetically-determined phenotypes very quickly in a population, a large-scale study examining whether high-sCD46 animals provide epidemiological protection against BVDV infection and transmission should be undertaken. [less ▲]

Detailed reference viewed: 15 (7 ULg)
Full Text
Peer Reviewed
See detailOrganic and mechanical properties of Cervidae antlers: a review
Picavet, Pierre; Balligand, Marc ULg

in Veterinary Research Communications (2016), 40(3), 141-147

Detailed reference viewed: 12 (0 ULg)
Full Text
See detailImportin-8 mutations could cause Jeavons Syndrome, CAE and JME by altering early neuroblast migration
Nganou, Gerry ULg; Tanaka, Miyabi; Coumans, Bernard ULg et al

Poster (2016, December)

Jeavons syndrome (JS) is an uncommon form of juvenile epilepsy. In some family affected by JS, the gene of importin-8 (IPO8) a member of karyopherin superfamily of proteins, has been found mutated ... [more ▼]

Jeavons syndrome (JS) is an uncommon form of juvenile epilepsy. In some family affected by JS, the gene of importin-8 (IPO8) a member of karyopherin superfamily of proteins, has been found mutated. Karyopherin are known to regulate nucleo-cytoplasmic transport of many proteins. IPO8, a member of the β-karyopherin sub-family, is reported to control the transport Ago-2, c-Jun and Smad-4 for example, three proteins important for brain development. Here, we show that IPO8 is well expressed in mouse brain at embryonic stage. Moreover inhibition of IPO8 mRNA by shRNA in-utéro-electroporation (IUE), impairs early neuroblast migration as weel as IUE overexpression of mutated form of human IPO8. So, abnormal brain development due to IPO8 mutations could be at the origin of Jeavons Syndrome, Chilhood abscence evolving (CAE) and/or juvenile myoclonic epilepsy (JME). [less ▲]

Detailed reference viewed: 22 (5 ULg)
See detailDu tell à l'histoire : stratégie et techniques de fouille au Proche-Orient
Mas, Juliette ULg

Scientific conference (2016, December)

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailNouveaux paradigmes et métaphores du traitement du mélanome cutané
PIERARD, Gérald ULg; NIZET, Jean-Luc ULg; HUMBERT, P.

in Revue Médicale de Liège (2016), 71(12), 562-566

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as ... [more ▼]

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as breakthroughs in the lay press and by some medical opinion leaders. Unfortunately, the use of inflated descriptors of the drug efficacy leads to misunderstandings among the clinicians in charge of patients. Currently, vemurafenib, ipilimumab, pembrolizumab and nivolumab have demonstrated their relative activity in the control of advanced malignant melanoma. The results expected from surrogate markers of efficacy are magnified and idealized regarding the expectations from many patients. The recent therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the current beneficial effects. [less ▲]

Detailed reference viewed: 30 (3 ULg)
Full Text
See detailFirst Hubble Space Telescope Movies of Jupiter’s Ultraviolet Aurora During the NASA Juno Prime Mission
Grodent, Denis ULg; Gladstone, G. Randall; Clarke, John T. et al

Poster (2016, December)

The primary goal of this HST campaign is to complement Juno-UVS (Ultraviolet Spectrograph) observations. This complementarity is four-fold as HST observes Jupiter’s aurora when: 1) Juno-UVS is turned off ... [more ▼]

The primary goal of this HST campaign is to complement Juno-UVS (Ultraviolet Spectrograph) observations. This complementarity is four-fold as HST observes Jupiter’s aurora when: 1) Juno-UVS is turned off, that is about 98% of Juno’s 14-day orbit, and Juno’s in situ instruments are in operation. 2) Juno-UVS is operating, but observes the opposite hemisphere of Jupiter. 3) UVS is on in the same hemisphere, but too close to Jupiter to have a global, contextual, view of the aurora and/or UVS is affected by the noise induced by Jupiter’s radiation belts. 4) Juno is too far from Jupiter to get a detailed view of the aurora. In addition, HST will observe the auroral and airglow emissions of the Galilean moons Io, Ganymede and Europa, when UVS is measuring their auroral footprints in Jupiter’s ionosphere. During this campaign, HST is obtaining 45-min STIS time-tag images -movies- of both hemispheres of Jupiter and STIS/COS spectra of Jupiter's moons. These observations are taking place during 4 sequences of Juno's orbit (Figure: typical orbit in magnetic coordinates): 1) Perijove segment: a 6-hour sequence bracketing the time of Juno's closest approach of Jupiter. 2) Crossing segments: few hours periods during which Juno is crossing the magnetic equator of Jupiter and in situ instruments are observing the plasma sheet particles. 3) Perijove +/- 1 Jovian rotation (or more), to provide a context for the auroral activity before and after perijove. 4) Apojove segment: a 12-hour period bracketing the time when Juno is farthest from Jupiter and Juno-UVS is continuously monitoring the global auroral UV power of Jupiter. During Juno orbit PJ5, between 28 Nov. and 07 Dec. 2016, HST obtains 9 STIS movies: 3 movies of the northern aurora near perijove, 1 movie (north) one Jovian rotation before and 2 movies (south- north) one and two Jovian rotations after perijove, 2 movies (north) during two close CS crossings, and 1 movie near apojove. These movies will be commented during this presentation. [less ▲]

Detailed reference viewed: 37 (2 ULg)
Full Text
See detailProperties of Jupiter’s auroral acceleration region inferred with HST-STIS spectral images
Ray, Licia C.; Arridge, Christopher S.; Gustin, Jacques et al

Poster (2016, December)

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. Precipitating auroral electrons are part of a current system which transports angular momentum from the planetary ... [more ▼]

Jupiter’s dynamic auroral region is the signature of magnetosphere-ionosphere coupling. Precipitating auroral electrons are part of a current system which transports angular momentum from the planetary atmosphere to sub-corotating magnetospheric plasma. The magnitude of the currents and hence precipitating energy flux, are sensitive to the characteristics of the high-latitude magnetosphere, in particular the location of the auroral acceleration region (AAR) and the density and temperature of the high-latitude electron population. We use HST STIS observations of Jupiter’s aurora (Gustin et al. [2016]) to infer the location of the AAR and the properties of the precipitating auroral electrons. To do this, we determine the energy of the precipitating electrons and incident energy flux for the two distinct regions within the main aurora and within flare regions. The resulting relationships between energy flux and electron precipitation energy for the main auroral emission are then compared to the theoretical relationship derived by Lundin & Sandahl [1978], in order to derive the location of the AAR and the temperatures and densities of the electrons at the top of the AAR prior to acceleration. We find that that each emission region is best reproduced using a multiple auroral acceleration regions with different properties, rather than a single auroral acceleration region with a varying potential drop strength. [less ▲]

Detailed reference viewed: 18 (2 ULg)
See detailContinuous Monitoring of Jupiter's Aurora and Io Plasma Torus with the Hisaki Satellite during Joint Observing Campaign with Juno
Kimura, Tomoki; Yamazaki, Atsushi; Murakami, Go et al

Poster (2016, December)

The Hisaki satellite is the first space telescope that is dedicated to observations of our solar system bodies. Hisaki has been continuously monitoring the atmosphere and magnetosphere of the solar system ... [more ▼]

The Hisaki satellite is the first space telescope that is dedicated to observations of our solar system bodies. Hisaki has been continuously monitoring the atmosphere and magnetosphere of the solar system bodies with the extreme ultraviolet (EUV) spectroscope EXCEED since the launch in September 2013. Dynamics on timescales from 10s minutes to a few years were discovered in the atmosphere and magnetosphere by the continuous monitoring. Large joint observing campaigns for Jupiter by the Juno spacecraft in coordination with Hisaki, the Hubble Space Telescope (HST), and other facilities started in mid-2016. Before Jupiter Orbit Insertion, Juno made the in-situ solar wind measurements while Hisaki was simultaneously monitoring Jupiter's aurora and Io plasma torus. On Day of Year 142, Hisaki discovered that the EUV auroral emission power rapidly increased by a factor of ~3 but returned to a nominal level within one planetary rotation. The transient aurora was followed by brightening of the torus sulfur and oxygen ions that is proxy of the hot electron populations in the torus. At the same time, the relatively weak solar wind shock signatures were found in the JUNO/JEDI energetic particle data (Clark et al.). The transient variability is compared to the morphology observed by HST (Nichols et al.). Hisaki is going to monitor Jupiter in collaboration with the large observing program of HST (Grodent et al.) that will make ~150 exposures from this November. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
See detailComment mieux valoriser les fourrages riches en azote ?
Herremans, Sophie ULg

Article for general public (2016)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailThe Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme
Ahn, Minkoo; Hagan; Bernardo-Gancedo et al

in Biophysical Journal (2016)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailSurfactant instillation in spontaneously breathing preterm infants: a systematic review and meta-analysis.
RIGO, Vincent ULg; LEFEBVRE, Caroline ULg; BROUX, Isabelle ULg

in European Journal of Pediatrics (2016), 175(12), 1933-1942

Less invasive surfactant therapies (LIST) use surfactant instillation through a thin tracheal catheter in spontaneously breathing infants. This review and meta-analysis investigates respiratory outcomes ... [more ▼]

Less invasive surfactant therapies (LIST) use surfactant instillation through a thin tracheal catheter in spontaneously breathing infants. This review and meta-analysis investigates respiratory outcomes for preterm infants with respiratory distress syndrome treated with LIST rather than administration of surfactant through an endotracheal tube. Randomised controlled trial (RCT) full texts provided outcome data for bronchopulmonary dysplasia (BPD), death or BPD, early CPAP failure, invasive ventilation requirements and usual neonatal morbidities. Relative risks (RR) from pooled data, with subgroup analyses, were obtained from a Mantel-Haenszel analysis using a random effect model. Six RCTs evaluated LIST: 4 vs InSurE and 1 each vs delayed or immediate intubation for surfactant. LIST resulted in decreased risks of BPD (RR = 0.71 [0.52-0.99]; NNT = 21), death or BPD (RR = 0.74 [0.58-0.94]; NNT = 15) and early CPAP failure or invasive ventilation requirements (RR = 0.67 [0.53-0.84]; NNT = 8 and RR = 0.69 [0.53-0.88]; NNT = 6). Compared to InSurE, LIST decreased the risks of BPD or death (RR = 0.63 [0.44-0.92]; NNT = 11) and of early CPAP failure (RR = 0.71 [0.53-0.96]; NNT = 11). Common neonatal morbidities were not different. CONCLUSIONS: Respiratory management with LIST decreases the risks of BPD and BPD or death, and the need for invasive ventilation. This strategy appears safe, but long-term follow-up is lacking. WHAT IS KNOWN: • Initial management of preterm infants with CPAP decreases the risk of death or BPD, but many still require surfactant or invasive ventilation. • Surfactant can be instilled through a tracheal thin catheter while the infant breathes on CPAP, but improvement in BPD is inconsistent between studies. What is New: • Less invasive surfactant therapy (LIST) strategies decrease the risks of BPD, of death or BPD, and of CPAP failure compared to strategies where surfactant is administered through an endotracheal tube. • LIST strategies decrease the risks of the composite outcome of BPD or death and of early CPAP failure when compared to "intubation-surfactant-extubation" approaches. [less ▲]

Detailed reference viewed: 17 (4 ULg)
Full Text
See detailAccompagnement de la mise en oeuvre des recommandations de la recherche sur les formations initiales : vers la mise en place d’un nouveau système - Rapport d'activités
Pirard, Florence ULg; Dethier, Anne ULg; Housen, Marie ULg

Report (2016)

Ce rapport rend compte des activités menées dans le suivi de la recherche sur les formations initiales dans le champ de l'accueil de l'enfance (Pirard al. 2015). Il garde trace des diverses communications ... [more ▼]

Ce rapport rend compte des activités menées dans le suivi de la recherche sur les formations initiales dans le champ de l'accueil de l'enfance (Pirard al. 2015). Il garde trace des diverses communications réalisées durant l'année 2016 et propose en conclusion des pistes de réflexion et d'action à poursuivre en vue d'une nécessaire réforme. [less ▲]

Detailed reference viewed: 7 (0 ULg)
See detailIntroduction to "Planned Obsolescence: Texts, Theory, Technology"
Guesse, Carole ULg; Dupont, Bruno ULg; Mingazova, Ella

Conference (2016, December)

As organizers, Bruno Dupont, Ella Mingazova and myself welcomed the participants and introduced the conference.

Detailed reference viewed: 20 (0 ULg)
Full Text
See detailNos patients cancéreux sont-ils déjà cachectiques lors de la première évéluation nutritionnelle ?
MALHERBE, Christian ULg; VERBRUGGE, Anne-Marie ULg; DE FLINES, Jenny ULg et al

Conference (2016, December)

we want to know if, during the first nutritional evaluation, our cancer patients are already cachectic or no. <in order to improve our institutional practices

Detailed reference viewed: 12 (2 ULg)
Full Text
See detailSystèmes d'informations foncières et politiques publiques : rapport scientifique 2015-2016
Hendrickx, Sébastien ULg; Grandjean, Martin; Marlier, Catherine et al

Report (2016)

Detailed reference viewed: 28 (3 ULg)
Full Text
Peer Reviewed
See detailQuels sont les risques d’une spécialisation sportive précoce sur la santé des enfants ?
Jidovtseff, Boris ULg

in Percentile (2016), 21(6), 6-10

Dans les années nonante, des études scientifiques ont démontré que pour espérer atteindre le niveau d’excellence dans certains domaines comme le sport, il fallait se spécialiser tôt et avec un engagement ... [more ▼]

Dans les années nonante, des études scientifiques ont démontré que pour espérer atteindre le niveau d’excellence dans certains domaines comme le sport, il fallait se spécialiser tôt et avec un engagement intense. Ceux qui commençaient trop tard avaient très peu de chance d’atteindre l’élite sportive. La médiatisation des sportifs précoces, l’apparition de compétitions importantes pour les jeunes, la recherche de performance dès l’enfance ont contribués au développement des approches sportives favorisant une spécialisation précoce. Pourtant les chercheur montrent que cette approche n’est pas très efficace, et surtout, peu affecter développement de l’enfant et de sa santé. Une pratique trop spécifique peut à long terme constituer une barrière motrice limitant l’enfant dans son développement. Les surcharges d’entraînement spécifique ainsi que certains comportements alimentaires affecteraient la fonction endocrine. La répétition intense de gestes stéréotypés favoriserait l’apparition des blessures. D’autres éléments comme la pression, le manque d’amusement ou le manque de temps pour d’autres activités peuvent conduire l’enfant au dégoût et à l’abandon précoce. Ces dernières années, des solutions alternatives et adaptées aux enfants émergent comme les modèles de développement à long terme préconisant la pratique polysportive et une spécialisation progressive. Les modèles de compétitions doivent être revus afin de favoriser prioritairement les apprentissages et non pas la performance. Finalement les modèles de pratique devraient idéalement prendre en compte tous les enfants, aussi bien ceux qui souhaitent faire du sport de compétition que ceux qui souhaitent faire du sport pour leur bien-être. [less ▲]

Detailed reference viewed: 40 (1 ULg)
Full Text
See detailTemps du patient, temps du docteur
Jamoulle, Marc ULg

in Ethica Clinica (2016), 84(4), 74-81

Detailed reference viewed: 70 (4 ULg)
Full Text
See detailManager une équipe en milieu d'accueil collectif (2)
Pirard, Florence ULg; Bockstael, Anne; Harzimont, Michaël

Article for general public (2016)

Detailed reference viewed: 29 (1 ULg)
Full Text
Peer Reviewed
See detailGenre et lutte contre le travail des enfants au Burkina Faso
Wouango, Joséphine ULg

in Jacquemin, Mélanie; Bonnet, Doris (Eds.) Etre fille ou garçon : regards croisés sur l’enfance et le genre au Nord et au Sud (2016)

La lutte contre le travail des enfants au Burkina Faso a resurgi dans la scène publique ces dix dernières années avec un engouement sans précédent aussi bien de la part des acteurs étatiques, des ONG que ... [more ▼]

La lutte contre le travail des enfants au Burkina Faso a resurgi dans la scène publique ces dix dernières années avec un engouement sans précédent aussi bien de la part des acteurs étatiques, des ONG que des organismes onusiens. Ce chapitre traite, dans une double perspective sociologique et anthropologique, de la dimension « genre » de cette lutte et cherche à voir dans quelle mesure celle-ci est prise en compte (ou non) dans les pratiques concrètes de retrait d’enfants des travaux considérés comme dangereux. Peut-on parler de politiques et de programmes « genrés » dans le champ de la lutte contre le travail des enfants au Burkina Faso ? Le chapitre est structuré en trois parties. Il présente d’abord les éléments caractéristiques de l’approche genre dans la lutte contre le travail des enfants. Ensuite, il aborde les politiques et les acteurs de cette lutte au Burkina Faso, en décrivant les processus de problématisation et publicisation de la question. Enfin, il traite du cas spécifique d’un projet triennal de retrait d’enfants des mines artisanales des régions du Nord et du Sahel burkinabè pour questionner la prise en compte du genre, des obstacles sociaux, culturels et d’autres contraintes possibles à l’égalité fille-garçon dans cette intervention. Il questionne par ailleurs la part des acteurs de terrain dans la (re)production des normes et des rôles sexués. Les données sont issues de quatre années de recherche menée au Burkina Faso entre 2008 et 2011, auprès d’acteurs engagés dans la production des politiques de lutte et/ou engagés dans la lutte concrète, mais également avec des enfants, parents et employeurs. [less ▲]

Detailed reference viewed: 58 (19 ULg)