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See detailRetour sur le délit collectif
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (16), 738-739

La nature réglementaire des infractions de non-paiement de rémunération ne les empêche pas de former un délit collectif

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See detailZonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Lesage, Julien; Suarez-Carmona, Meggy; Neyrinck-Leglantier, Deborah et al

in FASEB Journal (2017), 31(4), 1678-1688

Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the ... [more ▼]

Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO-1 in CXCL8/IL-8 chemokine expression in lung and breast tumor cells. ZO-1 small interfering RNA and cDNA transfection experiments emphasized regulation of CXCL8/IL-8 expression via a cytonuclear pool of ZO-1. Luciferase reporter assays highlighted a 173-bp region of CXCL8/IL-8 promoter that responded to ZO-1. Moreover, by using mutated promoter constructs, we identified a NF-κB site as critical in this activation. Furthermore, NF-κB pathway signaling analysis revealed both IκBα and p65 phosphorylation in ZO-1-overexpressing cells, and subsequent p65 silencing validated its requirement for CXCL8/IL-8 induction. Investigation of the functional implication of this regulatory axis next showed the proangiogenic activity of ZO-1 in both ex vivo and in vivo angiogenesis assays. Finally, we found that non-small-cell lung carcinoma that presented a cytonuclear ZO-1 pattern was significantly more angiogenic that that without detectable cytonuclear ZO-1 expression. Taken together, our results demonstrate that ZO-1 regulates CXCL8/IL-8 expression via the NF-κB signaling pathway and its p65 subunit, which subsequently modulates the transcription of IL-8. We also provide evidence of a newly identified regulatory pathway that could promote angiogenesis. Thus, our results support the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect both the intrinsic invasive properties of tumor cells and the establishment of the protumoral microenvironment. [less ▲]

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See detailEtude comparative des profils de dissolution in vitro de quinine sulfate générique et princeps en utilisant la Chromatographie Liquide Haute Performance
Mbinze Kindenge, Jérémie ULg; Diallo, Tediane; Yemoa, Loconon ULg et al

in Médecine d'Afrique Noire (2017), 64

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses ... [more ▼]

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses médicaments génériques d’une part, et au fléau des médicaments de qualité inférieure d’autre part, il devient plus que nécessaire d’appuyer les données des tests physico-chimiques par celles de dissolution in vitro dont l’évaluation et la comparaison des cinétiques permettra de prédire le comportement in vivo du principe actif et par conséquent l’efficacité du médicament générique. L’objectif de la présente étude est de réaliser une étude comparative de la cinétique de dissolution d’un princeps et d’un générique à base de quinine comprimé 300 mg commercialisés à Kinshasa. Matériels et méthodes : L’étude a été réalisée en utilisant trois milieux de pH différents (1,2 - 4,5 - 6,8) tels que recommandés par l’Agence Européenne de Médicament et en se servant d’un appareil de dissolution, tandis que l’équipement de chromatographie liquide à haute performance couplée à un détecteur à barrette de diodes a été utilisé pour la quantification. La méthode statistique fit factor a été appliquée pour comparer les résultats de dosage de la quinine dans les trois milieux tout en ayant évalué le biais à différents temps de dissolution. Résultats : Les différents échantillons de médicaments générique et princeps ont été conformes quant à l’identification et au dosage de la quinine, par contre leurs cinétiques de dissolution étaient non similaires. Discussion : Ceci pourrait avoir une influence sur l’efficacité du produit générique et la sécurité des consommateurs, dénotant l’importance d’examiner les profils de dissolution des génériques avant toute autorisation de mise sur le marché plus particulièrement dans les pays en voie de développement. [less ▲]

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See detailDiscovery of a woman portrait behind La Violoniste by Kees Van Dongen through hyperspectral imaging
Herens, Elodie ULg; Defeyt, Catherine ULg; Walter, Philippe et al

in Heritage Science (2017), 5(14),

Despite the fact that Kees Van Dongen was one of the most famous painter of the 20th century, only little information about his palette and his technique is available. To contribute to the ... [more ▼]

Despite the fact that Kees Van Dongen was one of the most famous painter of the 20th century, only little information about his palette and his technique is available. To contribute to the characterization of Van Dongen's painting materials, La Violoniste, painted by the artist around 1923, has been analyzed by using three complementary techniques: macro X-ray fluorescence (MA-XRF), Raman spectroscopy and hyperspectral imaging. The elemental repartition given by MA-XRF and the results obtained thanks to Raman spectroscopy help us to complete the identification of pigments contained in La Violoniste (lead white, iron oxides, cadmium yellow, vermilion, Prussian blue, titanium white, ultramarine, a chromium pigment and carbon black) while the results obtained via hyperspectral imaging reveal a hidden woman portrait. Besides the fact that Kees Van Dongen was particularly renowned for his female portraits, this hidden composition presents obvious stylistic similarities with the well-known portraits produced by the artist during his Parisian stay (starting from 1899). Thanks to Raman spectroscopy, visual examination and MA-XRF, we show that the original background contains ultramarine, the hidden portrait's clothes are probably made of the same colour as the present violinist's dress and her carnation contains zinc, contrary to the violinist's flesh which is mainly made of lead white. [less ▲]

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See detailIgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case report
HUART, Justine ULg; GROSCH, Stéphanie ULg; BOVY, Christophe ULg et al

in BMC Nephrology (2017), 18

Abstract Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney ... [more ▼]

Abstract Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney involvement is quite peculiar and has only been described a few times recently. Renal biopsy showed a glomerular involvement with membranous glomerulonephritis in association with a tubulo-interstitial nephropathy. Moreover, the patient was not suffering from pancreatitis. Case presentation: The patient is a middle-aged man of Moroccan origin. He has developed recurrent episodes of diffuse lymphadenopathies, renal failure and nephrotic syndrome. Renal biopsies showed membranous glomerulonephritis. Discussion and conclusion: The diagnostic approach of this atypical presentation is discussed in this case report as well as diagnostic criteria, therapeutic strategies, biomarkers and pathophysiology of IgG4-related disease. IgG4-related membranous glomerulonephritis is a well-established cause of membranous glomerulonephritis. It must be sought after in every patient with a previous diagnosis of IgG4-related disease and in every patient with this histological finding on renal biopsy. Corticoids are still the first-line treatment of IgG4-related disease. New therapeutic strategies are needed to avoid glucocorticoids long term side-effects. Interestingly, the patient was prescribed cyclophosphamide in addition to glucocorticoids for an immune thrombocytopenia. This treatment had a very good impact on his IgG4-related disease. [less ▲]

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See detailTraduction en français du "back pain attitudes questionnaire" et étude de ses qualités métrologiques
Demoulin, Christophe ULg; hALLEUX, V.; DARLOW, B. et al

in Kinesitherapie Revue (2017, April), 184

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See detailContrôle du mouvement lombopelvien et football
Grosdent, Stéphanie ULg; Demoulin, Christophe ULg; Cortès Flores, A. et al

in Kinesitherapie Revue (2017, April), 184

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See detailSystematic flood modelling to support flood-proof urban design
Bruwier, Martin ULg; Mustafa, Ahmed; Aliaga, Daniel et al

Poster (2017, April)

Urban flood risk is influenced by many factors such as hydro-meteorological drivers, existing drainage systems as well as vulnerability of population and assets. The urban fabric itself has also a complex ... [more ▼]

Urban flood risk is influenced by many factors such as hydro-meteorological drivers, existing drainage systems as well as vulnerability of population and assets. The urban fabric itself has also a complex influence on inundation flows. In this research, we performed a systematic analysis on how various characteristics of urban patterns control inundation flow within the urban area and upstream of it. An urban generator tool was used to generate over 2,250 synthetic urban networks of 1 km². This tool is based on the procedural modelling presented by Parish and Müller (2001) which was adapted to generate a broader variety of urban networks. Nine input parameters were used to control the urban geometry. Three of them define the average length, orientation and curvature of the streets. Two orthogonal major roads, for which the width constitutes the fourth input parameter, work as constraints to generate the urban network. The width of secondary streets is given by the fifth input parameter. Each parcel generated by the street network based on a parcel mean area parameter can be either a park or a building parcel depending on the park ratio parameter. Three setback parameters constraint the exact location of the building whithin a building parcel. For each of synthetic urban network, detailed two-dimensional inundation maps were computed with a hydraulic model. The computational efficiency was enhanced by means of a porosity model. This enables the use of a coarser computational grid , while preserving information on the detailed geometry of the urban network (Sanders et al. 2008). These porosity parameters reflect not only the void fraction, which influences the storage capacity of the urban area, but also the influence of buildings on flow conveyance (dynamic effects). A sensitivity analysis was performed based on the inundation maps to highlight the respective impact of each input parameter characteristizing the urban networks. The findings of the study pinpoint which properties of urban networks have a major influence on urban inundation flow, enabling better informed flood-proof urban design. [less ▲]

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See detailMethodological sifting: the role of researchers in the production of social knowledge for trade union
Joiris, Jessica ULg; Fox, Fanny ULg; Naedenoen, Frédéric ULg et al

Conference (2017, April)

This presentation focuses on the role of social and management sciences researchers in enacting knowledge for social action, in the specific field of trade unionism. It draws on our experience, as ... [more ▼]

This presentation focuses on the role of social and management sciences researchers in enacting knowledge for social action, in the specific field of trade unionism. It draws on our experience, as researchers from two different research centres of the University of Liège2, in conducting a short-term intervention research ordered by a Belgian trade union. Our objective was to provide trade union delegates with educational and methodological support for launching a strategic reflexion on the union’s positioning regarding the challenges brought about by the digitalisation of work. We describe both the methodological framework implemented by the researchers (a questionnaire survey and focus groups) and the educational device settled by the union, which was aimed at enhancing the trade union delegates’ experience of digitalisation. This process that stimulates knowledge production and circulation is analysed on the basis of the phenomenology of knowledge defined by Freeman and Sturdy (2014). We first discuss the nature of our relationship with trade union executives who ordered the research. We particularly emphasise the role of three factors, namely trust (taming between two organizational cultures), time (strong pressure due to the preparation of the congress) and contingency (due to the lack of decision-making power of the steering committee), in (re- )framing the research project and thereby influencing knowledge production. Then, we describe the role performed by researchers as a role of methodological sifting that consists in imposing different frames on the trade union delegates’ experience of digitalisation. Ranging from « meeting frame » to questionnaires, the researchers’ sifts give different forms (inform) to delegates’ knowledge – which was inscribed in documents meant at circulating the union’s official position on digitalisation; enacted through different events as focus groups and conferences; and embodied by the union delegates who took part in the process. [less ▲]

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See detailHow to Reduce Rejection of Service Innovations? Uncovering Consumers’ Desired Organizational Actions in Access-Based Services
Hazee, Simon ULg; Delcourt, Cécile ULg; Van Vaerenbergh, Yves et al

Scientific conference (2017, April)

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See detail« Antigone » en droit fiscal : quelle évolution ?
Bourgeois, Marc ULg; Verscheure, Céline ULg

in Bourgeois, Marc; Verscheure, Céline; Herbecq, François (Eds.) et al Le droit fiscal en 2017 : questions choisies (2017)

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See detailAn exceptionally preserved and diverse assemblage of organic-walled microfossils from the Proterozoic of Arctic Canada.
Loron, Corentin ULg; Rainbird, Robert; Greenman, Wilder et al

Conference (2017, April)

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See detailcrossroads, le magazine sonore du blues et des musiques américaines
Sacré, Robert ULg

Diverse speeche and writing (2017)

Magazine sonore du Blues et des musiques américaines. Chaque mercredi de 18h à 20h; rediffusion chaque samedi de 22h à minuit. streaming: www.equinoxefm.be ; podcasts www.mixcloud.com/robertsacre9; infos ... [more ▼]

Magazine sonore du Blues et des musiques américaines. Chaque mercredi de 18h à 20h; rediffusion chaque samedi de 22h à minuit. streaming: www.equinoxefm.be ; podcasts www.mixcloud.com/robertsacre9; infos www.facebook.com/robert.sacre.9 [less ▲]

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See detail18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma: A case report.
Liu, Willy; Delwaide, Jean ULg; BLETARD, Noëlla ULg et al

in World Journal of Hepatology (2017), 9(11), 562-566

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and ... [more ▼]

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take. [less ▲]

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See detailHST observations of Jupiter's UV aurora during Juno's orbits PJ03, PJ04 and PJ05
Grodent, Denis ULg; Gladstone, G Randall; Clarke, John T. et al

Poster (2017, April)

The intense ultraviolet auroral emissions of Jupiter are currently being monitored in the frame of a large Hubble Space Telescope (HST) program meant to support the NASA Juno prime mission. The present ... [more ▼]

The intense ultraviolet auroral emissions of Jupiter are currently being monitored in the frame of a large Hubble Space Telescope (HST) program meant to support the NASA Juno prime mission. The present study addresses the three first Juno orbits (PJ03, 04 and 05) during which HST obtained parallel observations. These three campaigns basically consist of a 2-week period bracketing the time of Juno’s closest approach of Jupiter (CA). At least one HST visit is scheduled every day during the week before and the week following CA. During the ∼12-hour period centered on CA and depending on observing constraints, several HST visits are programmed in order to obtain as many simultaneous observations with Juno-UVS as possible. In addition, at least one HST visit is obtained near Juno’s apojove, when UVS is continuously monitoring Jupiter’s global auroral power, without spatial resolution, for about 12 hours. We are using the Space Telescope Imaging Spectrograph (STIS) in time-tag mode in order to provide spatially resolved movies of Jupiter’s highly dynamic aurora with timescales ranging from seconds to several days. We discuss the preliminary exploitation of the HST data and present these results in such a way as to provide a global magnetospheric context for the different Juno instruments studying Jupiter’s magnetosphere, as well as for the numerous ground based and space based observatories participating to the Juno mission. [less ▲]

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