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See detailDevelopment and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs
Karim, Reatul ULg; Palazzo, Claudio ULg; Laloy, Julie et al

Poster (2016, December)

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site ... [more ▼]

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility. [less ▲]

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See detailIntramolecular continuous-flow strategy towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

Poster (2016, December)

threo-Methylphenidate hydrochloride is the most widely prescribed drug to treat attention deficit hyperactivity disorder (ADHD). Herein we present the batch-to-flow translation of a carbene-based ... [more ▼]

threo-Methylphenidate hydrochloride is the most widely prescribed drug to treat attention deficit hyperactivity disorder (ADHD). Herein we present the batch-to-flow translation of a carbene-based intramolecular strategy for the diastereoselective preparation of this active pharmaceutical ingredient. The process relies on the thermal generation and decomposition of a hazardous diazospecies, its thermal intramolecular C-H insertion reaction yielding an intermediate β-lactam, and its subsequent acidic methanolysis, giving enriched threo-methylphenidate hydrochloride in 70% isolated yield. The automated microfluidic setup telescopes 2 chemical transformations, 1 intermediate in-line purification and sustains a daily productivity of 20.4 g/day of methylphenidate hydrochloride. The preparation of the β-lactam is implemented on mesoscale in a pilot-scale continuous-flow reactor, providing 4.25 kg of this key intermediate per day. [less ▲]

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See detailIncentives and barriers to environmental inequality mobilization: A case-study analysis in Wallonia, Belgium
Lejeune, Zoé ULg; Teller, Jacques ULg

in Environmental Science and Policy (2016), 66

Environmental inequality scholarship has sought to shed light on the unequal environmental conditions borne by poor people and racial minorities, and to challenge public policies. Most studies are ... [more ▼]

Environmental inequality scholarship has sought to shed light on the unequal environmental conditions borne by poor people and racial minorities, and to challenge public policies. Most studies are concerned either with assessing the unequal distribution of environmental amenities and disamenities or with exploring the theoretical foundations of environmental justice movements. We propose an original approach to environmental inequality, focused not only on the unequal distribution of environmental burdens but also on two other types of factors: the capacity to mobilize and engage in community organizations on the one hand and the spatial dimension of environmental inequalities on the other. The evidence for this study is from an opinion survey carried out in 2012 with 1298 individuals. We use a two-step cluster analysis method to compute a classification system based on four categories of variables: socio-economic, environmental, spatial, and social capital. [less ▲]

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See detailRéforme du bonus logement et instauration du Chèque habitat en Wallonie
Voisin, Fanny ULg

in Les Echos du Logement (2016), 118

Description technique de la réforme du bonus logement entreprise en Région wallonne pour les contrats d’emprunt hypothécaire conclus au plus tard le 31 décembre 2015 et pour les contrats d’emprunt ... [more ▼]

Description technique de la réforme du bonus logement entreprise en Région wallonne pour les contrats d’emprunt hypothécaire conclus au plus tard le 31 décembre 2015 et pour les contrats d’emprunt hypothécaire conclus à partir du 1er janvier 2016. [less ▲]

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See detailImpact de l’érosion sur l’envasement des barrages, la recharge des nappes phréatiques côtières et les intrusions marines dans la zone semi-aride méditerranéenne : cas du barrage de Boukourdane (Algérie)
Tadrist, Nassima ULg; Debauche, Olivier

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(4), 453-467

Description of the subject. Water erosion is a particularly important issue, especially in the Mediterranean and semi-arid zone. This zone is characterized by irregular rainfall patterns, which have a ... [more ▼]

Description of the subject. Water erosion is a particularly important issue, especially in the Mediterranean and semi-arid zone. This zone is characterized by irregular rainfall patterns, which have a considerable influence on soil loss. In mountainous areas, water erosion phenomena are accentuated by steep slopes and low ground cover. The dams draining these areas undergound siltation linked to significant erosion. The silting of the dams drastically limits their capacity and thus their operating life. When used for recharging aquifers, the resuspension of fine particles may accumulate in the recharge areas and reduce infiltration capacity by clogging soil porosity. This leads to a significant reduction of groundwater levels. Additionally, groundwater situated in the coastal zone is submitted to intensive pumping. These two phenomena make groundwater particularly sensitive to marine intrusions. Objectives. This article aims, on the one hand to quantify the rate of siltation in the case of the Boukourdane dam (northern Algeria), which is used to recharge groundwater. On the other hand, the article also shows the reduction in permeability in the capturing field with the current management of releases. Method. Solid rates were set in relation to the liquid flow and sediment concentration occasionally taken from the wadi. The relation established made it possible to evaluate the solid contributions to the dam of Boukourdane. The impact of the releases on recharging the well field was evaluated by grouping wells and the well field mushrooms using heuristic k-means. Regressions were applied to the piezometric variations of each group. Results. This dam is fed by a catchment area of 156 km². Sediment transport was estimated from empirical formulas. The specific degradation rate was estimated at 366 t.km-2.year-1 during the 1993 to 2005 period. The increase in the frequency of extreme rainfall resulted in an increase in the soil erosion rate to 446 t.km-2.year-1 during the 1993 to 2013 period. The volume of sediments accumulated in the dam reached 8.104 m³.year-1 and 11.104 m³.year-1 respectively during these two periods. Conclusions. A change in the management of current releases has a positive impact on the partial restoration of the hydraulic conductivity and de facto, on the fight against marine intrusion. [less ▲]

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See detailSoutenir les proches d'une personne incarcérée. L'accompagnement d'un Service d'Aide aux justiciables.
Garcet, Serge ULg; Lecomte, Romain

in L'Observatoire (2016), 89(novembre/décembre), 46-49

Interview par R. Lecomte dans le cadre du dossier spécial "travail avec les proches" autour de la thématique de l'aide apportée aux détenus et à leurs proches.

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See detailApplication of Uncoupled Damage Models to Predict Ductile Fracture in Sheet Metal Blanking
Canales Cardenas, Cristian ULg; Boman, Romain ULg; Ponthot, Jean-Philippe ULg

in Key Engineering Materials (2016), 725

The use of uncoupled damage models has been widely used over the years for the prediction of ductile fracture in engineering applications. Nevertheless, its applicability in the prediction of failure has ... [more ▼]

The use of uncoupled damage models has been widely used over the years for the prediction of ductile fracture in engineering applications. Nevertheless, its applicability in the prediction of failure has been shown to be limited in the wide range of loading conditions encountered in different manufacturing processes. In order to enhance the formulation of former damage models, the Lode angle has been recently used to characterize the stress states along with the stress triaxiality. This new family of damage models has been demonstrated to give excellent results when proportional loading paths are considered, but its efficiency in more complex applications still need further analysis. To this end, a comparative study of former and recently developed uncoupled damage models is performed in this work. The identification of material parameters is done considering simple mechanical tests under different conditions. Then, the models are used to predict the onset and propagation of cracks during blanking, where numerical predictions are compared with experimental results. Finally, the selected damage models presented a remarkable overall performance in the range of clearances under study. [less ▲]

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See detail共生菌Hamiltonella defensa对蚜虫的影响
Guo, Jianqing ULg; Wang, Zhenying

in 中国青年植保科技创新 (2016, December)

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See detailÉtude du degré de satisfaction de patients lombalgiques au sujet du site internet éducatif « Retrain Pain »
Demoulin, Christophe ULg; Blanc, A.; Wolfs, Sébastien ULg et al

in Revue du Rhumatisme (2016, December), 83S

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See detailEfficacité d’un programme de rééducation active pluridisciplinaire du dos : suivi de 812 patients lombalgiques chroniques
Mahieu, Geneviève; Boogaerts, M.; Tordeurs, D. et al

in Revue du Rhumatisme (2016, December), 83S

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See detailTerminologie multilingue de médecine générale et de famille - Version française
Jamoulle, Marc ULg; Ouvrard, Patrick; Schuers, Matthieu

Book published by Care Edition (2016)

La présente monographie reproduit, sous le nom de «Les Q-Codes et la terminologie multilingue de médecine générale et de famille - version française» la liste des Q-Codes et de leur définitions. Les Q ... [more ▼]

La présente monographie reproduit, sous le nom de «Les Q-Codes et la terminologie multilingue de médecine générale et de famille - version française» la liste des Q-Codes et de leur définitions. Les Q-Codes, classification des items non- cliniques de la médecine générale et de famille, ont été élaborés sous une forme compatible avec le développement d’une ontologie informatique sur le serveur web www.hetop.eu du laboratoire de bioinformatique de l’Université de Rouen, France. Les Q-Codes tendent à représenter l’essentiel des concepts organisationnels de la Médecine de Famille. Les Q-codes forment un chapitre complémentaire à la Classification Internationale des Soins Primaires, deuxième édition (CISP-2). Ils font partie du projet 3CGP (Core Content Classification in Primary Care – Classification du Contenu Essentiel des Soins Primaires). 3CGP allie donc la CISP-2 et les Q-Codes à des fins d’indexation documentaire. Le projet d’un système d’indexation spécifique de la médecine de famille est expliqué et les capacités du serveur web HeTOP sont détaillées. On trouvera ensuite la liste tabulaire des Q-Codes, puis la liste des définitions utilisées suivi d’un index. [less ▲]

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See detailTerminología multilingüe en medicina general y de familia - Versión en Español
Jamoulle, Marc ULg; Mariño, María Ana; La Valle, Ricardo et al

Book published by Care Editions (2016)

Esta monografía reproduce la lista de códigos Q, versión 2.5, y sus definiciones bajo el nombre de “Terminología multilingüe en medicina general y de familia – versión española” La clasificación Códigos-Q ... [more ▼]

Esta monografía reproduce la lista de códigos Q, versión 2.5, y sus definiciones bajo el nombre de “Terminología multilingüe en medicina general y de familia – versión española” La clasificación Códigos-Q para artículos no clínicos de medicina general y de familia se ha diseñado en base al desarrollo de una ontología informática en el servidor web www.hetop.eu del Laboratorio de Bioinformática de la Universidad de Rouen, Francia. Los Códigos Q tienden a representar los conceptos organizacionales esenciales de la Medicina Familiar. Los Códigos Q forman un capítulo complementario en la Clasificación Internacional de Atención Primaria, segunda edición (CIAP-2). Ellos son parte del proyecto 3CGP (Core Content Classification in General Practice Family medicine - Clasificación del contenido esencial de la atención primaria). Por lo tanto, combina las 3CGP con la clasificación ICPC-2 y los Códigos Q con el propósito de la indexación documental en medicina general y de familia. El proyecto de un sistema específico de indexación en medicina familiar se explica con precisión así como la capacidad del servidor web HeTOP es desarrollada en detalle. Se describe a continuación una lista tabular de los Códigos-Q, sus definiciones y finalmente un índice terminológico. [less ▲]

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See detailAttack-Prevention and Damage-Control Investments in Cybersecurity
Lam, Wing Man Wynne ULg

in Information Economics and Policy (2016)

Detailed reference viewed: 47 (8 ULg)
See detailTerminologia Multilíngue de Clínica Geral / Medicina de Família e Comunidade - Versão em Português
Jamoulle, Marc ULg; Treuherz, Arthur; Gomes, Luis Filipe et al

Book published by Care Edition (2016)

Esta monografia reproduz, sob o nome de Terminologia Multilíngue de Clinica Geral (CG)/Medicina de Família e Comunidade (MFC), a lista de Códigos Q e suas definições, conforme desenvolvidos em um formato ... [more ▼]

Esta monografia reproduz, sob o nome de Terminologia Multilíngue de Clinica Geral (CG)/Medicina de Família e Comunidade (MFC), a lista de Códigos Q e suas definições, conforme desenvolvidos em um formato pronto para ontologia no servidor web www.hetop.eu do laboratório de bioinformática da Universidade de Rouen, França. Os Códigos Q visam representar o essencial dos conceitos organizacionais da Clinica Geral/Medicina de Família e Comunidade. Os Códigos Q, classificação complementar à CIAP-2, são parte do projeto 3CGP (Core Content Classification in Primary Care), sigla para Classificação de Conceitos Centrais em Atenção Primária. A 3CGP se junta à CIAP-2 e aos Códigos Q com fins de indexação documental. Nesta monografia, além do projeto como um todo é descrita uma visão geral do Servidor Web HeTOP. Finalmente estão listadas as definições e os Códigos Q. [less ▲]

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See detailDeep Reinforcement Learning Solutions for Energy Microgrids Management
François-Lavet, Vincent ULg; Taralla, David; Ernst, Damien ULg et al

in European Workshop on Reinforcement Learning (EWRL 2016) (2016, December)

This paper addresses the problem of efficiently operating the storage devices in an electricity microgrid featuring photovoltaic (PV) panels with both short- and long-term storage capacities. The problem ... [more ▼]

This paper addresses the problem of efficiently operating the storage devices in an electricity microgrid featuring photovoltaic (PV) panels with both short- and long-term storage capacities. The problem of optimally activating the storage devices is formulated as a sequential decision making problem under uncertainty where, at every time-step, the uncertainty comes from the lack of knowledge about future electricity consumption and weather dependent PV production. This paper proposes to address this problem using deep reinforcement learning. To this purpose, a specific deep learning architecture has been designed in order to extract knowledge from past consumption and production time series as well as any available forecasts. The approach is empirically illustrated in the case of a residential customer located in Belgium. [less ▲]

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See detailEen meertalige terminologie in de huisartsgeneeskunde - Nederlandse versie
Jamoulle, Marc ULg; Brouns, Johan; Steylaerts, Carl et al

Book published by Care Edition (2016)

Deze monografie geeft, onder de naam Een meertalige terminologie in huisartsgeneeskunde – neederlandse versie de lijst van de Q-Codes en de bijbehorende definities weer. Q-Codes, classificatie van niet ... [more ▼]

Deze monografie geeft, onder de naam Een meertalige terminologie in huisartsgeneeskunde – neederlandse versie de lijst van de Q-Codes en de bijbehorende definities weer. Q-Codes, classificatie van niet-klinische items van de husiartsgeneeskunde, ontwikkeldin een vorm die compatibel is met de ontwikkeling van een ontologie. Die ontologie kan u op de webserver www.hetop.eu van het laboratorium van bio-informatica van de Universiteit van Rouen (Frankrijk) vinden. Q-Codes hebben tot doel om het merendeel van de organisatie-concepten van de huisartsgeneeskunde te vertegenwoordigen. Q-codes vormen een aanvullend hoofdstuk van de Internationa Classification in Primary Care – second version (ICPC-2). Ze maken deel uit van het 3CGP-project (Core Content Classification in General Practice/Family Medicine). 3CGP combineert dus de ICPC-2 en de Q-Codes voor het indexeren van documenten (artikelen, abstracts van congressen). Eersts wordt de ontwikkeling uitgelegd van dit indexatie systeem, specifiek voor de huisartsgeneeskunde. Daarna worden de mogelijkheden van de webserver HeTOP gedetailleerd toegelicht. De lijst van Q-Codes wordt voorgesteld in tabelvorm, met vervolgens de gebruikte definites, gevolgd door een index. [less ▲]

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See detailDanh mục thuật ngữ đa ngôn ngữ về y học tổng quát và y học gia đình - Phiên bản tiếng Việt
Jamoulle, Marc ULg; Nguyễn Thùy, Châu; Trần Thị Hoa, Vi et al

Book published by CARE Editions - D/2016/7848/06 (2016)

Tài liệu này mang tên Từ điển thuật ngữ đa ngôn ngữ sử dụng trong Y học Tổng quát và Y học Gia đình - phiên bản tiếng Việt, được phiên dịch trực tiếp từ bản tiếng Pháp với sự đồng ý của tác giả Marc ... [more ▼]

Tài liệu này mang tên Từ điển thuật ngữ đa ngôn ngữ sử dụng trong Y học Tổng quát và Y học Gia đình - phiên bản tiếng Việt, được phiên dịch trực tiếp từ bản tiếng Pháp với sự đồng ý của tác giả Marc Jamoulle. Tài liệu tập trung giới thiệu chi tiết các thuật ngữ và định nghĩa đi kèm của bảng mã Q-codes. Đây là bảng danh mục các thuật ngữ đề cập các vấn đề không thuộc khía cạnh lâm sàng, được sử dụng trong chuyên ngành Y học Tổng quát và Y học Gia đình. Bộ danh mục này được nghiên cứu phát triển trên cơ sở sử dụng các công cụ khác nhau chuyền về thuật ngữ (ứng dụng chạy trên máy chủ tại www.hetop.eu của phòng thí nghiệm tin sinh học thuộc Đại học Rouen, nước Pháp). Mục đích của bảng mã Q-codes là nhằm giúp mô tả các phạm trù hệ thống mang tính đặc thù của chuyên ngành Y học gia đình. Q-codes đóng góp như một chương bổ sung thêm cho Bảng phân loại quốc tế dành cho chăm sóc ban đầu, phiên bản thứ 2 (ICPC-2). Q-codes cũng là một phần của đề án 3CGP (Core Content Classification in Primary Care – Classification du Contenu Essentiel des Soins Primaires). Trong đó, 3CGP kết hợp ICPC-2 và Q-codes nhằm giúp thiết lập chỉ mục qui chiếu cho các tài liệu. Trong tài liệu này, tác giả cũng giới thiệu khái quát về hệ thống lập chỉ mục chuyên biệt cho chuyên ngành y học gia đình. Một số thông tin về ứng dụng HeTOP dùng để xây dựng bộ danh mục này cũng sẽ được trình bày trong mục riêng. Phần cuối của tài liệu sẽ được sử dụng để giới thiệu chi tiết nội dung và các định nghĩa liên quan của bảng danh mục mã Q­ codes. [less ▲]

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See detailPulsations of the polar cusp aurora at Saturn
Palmaerts, Benjamin ULg; Radioti, Aikaterini ULg; Roussos, E. et al

in Journal of Geophysical Research. Space Physics (2016), 121

The magnetospheric cusp is a region connecting the interplanetary environment to the ionosphere and enabling solar wind particles to reach the ionosphere. We report the detection of several isolated high ... [more ▼]

The magnetospheric cusp is a region connecting the interplanetary environment to the ionosphere and enabling solar wind particles to reach the ionosphere. We report the detection of several isolated high-latitude auroral emissions with the Ultraviolet Imaging Spectrograph of the Cassini spacecraft. We suggest that these auroral spots, located in the dawn-to-noon sector and poleward of the main emission, are the ionospheric signatures of the magnetospheric cusp, in agreement with some previous observations with the Hubble Space Telescope. The high-latitude cusp auroral signature has been associated with high-latitude lobe reconnection in the presence of a southward interplanetary magnetic field. The occurrence rate of the polar cusp aurora suggests that lobe reconnection is frequent at Saturn. Several auroral imaging sequences reveal a quasiperiodic brightening of the polar cusp aurora with a period in the range of 60 to 70 min. Similar pulsations in the energetic electron fluxes and in the azimuthal component of the magnetic field are simultaneously observed by Cassini instruments, suggesting the presence of field-aligned currents. Pulsed dayside magnetopause reconnection is a likely common triggering process for the cusp auroral brightenings at Saturn and the quasiperiodic pulsations in the high-latitude energetic electron fluxes. [less ▲]

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See detailL’« ordre géométrique » et le dispositif argumentatif des Méditations métaphysiques de René Descartes
Dubouclez, Olivier ULg

in Revue d'Histoire des Sciences (2016), 69(2), 255-278

Summary : Although nothing shows at first sight that the Metaphysical meditations are built in accordance with a mathematical model, Des- cartes’ claim to have followed the « mos geometricus » invites us ... [more ▼]

Summary : Although nothing shows at first sight that the Metaphysical meditations are built in accordance with a mathematical model, Des- cartes’ claim to have followed the « mos geometricus » invites us to pass over that first impression and to reconsider the Cartesian art of medita- tion. Descartes’ main letters of 1640 (where he describes and also criti- cizes his metaphysical method) along with the last pages of the Second replies of 1641 reveal indeed a mathematical pattern of argumentation based on the classical notion of geometrical analysis. But, if analysis plays an active role in the realization of the « order of reasons » within the context of hyperbolic doubt, its is deeply transformed by Descartes and amounts to a combination of two argumentative tools, namely sup- position and enumeration, which are common to geometry and meta- physics. This article suggests in which sense the very method of Cartesian metaphysics, while not following a strictly linear « chain of reasons », can be genuinely said geometrical. [less ▲]

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