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See detailLes Hormones Glycoprotéiques: de la Clinique à la Recherche.
VALDES SOCIN, Hernan Gonzalo ULg

Doctoral thesis (2017)

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See detailLe volontariat : un levier vers l'emploi ?
Orianne, Jean-François ULg

Conference given outside the academic context (2017)

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See detailActivational and organizational disruption of folliculogenesis and estrous cycle caused by exposure to Bisphenol A (BPA) during early postnatal or adult life
Lopez Rodriguez, David ULg; Franssen, Delphine ULg; GERARD, Arlette ULg et al

Conference (2017, May 05)

Our previous studies have shown that an early postnatal exposure to a very low dose of bisphenol A (BPA) disrupts sexual maturation and pubertal timing. However, the long-term effects of such low dose ... [more ▼]

Our previous studies have shown that an early postnatal exposure to a very low dose of bisphenol A (BPA) disrupts sexual maturation and pubertal timing. However, the long-term effects of such low dose exposure as well as the effects of adult exposure have not been studied. One day-old and 90 day-old female rats received daily subcutaneous injections of corn oil (vehicle) or BPA (25ng/kg/d or 5mg/kg/d) for 15 days. The early postnatal exposure to both BPA doses significantly decreased the percentage of females with a regular cycle (BPA-25ng: 51±15%; BPA-5mg: 7±7%; OIL: 86±2%). The estrus cycle alterations were characterized by a decrease in time spent in proestrus (BPA-25ng: 13±3%; BPA-5mg: 12±3%; OIL: 18±3%). During adult exposure, both doses caused a disruption of the estrous cycle characterized by a significant decrease in the average time spent in proestrus (BPA-25ng: 19±2%; BPA-5mg: 17±1%; OIL: 23±1%). This effect was transient as the exposed females showed a regular cycle one month after the last dose of BPA. After adult exposure, we also observed a disruption of folliculogenesis characterized by a significant decrease of antral follicles (BPA-25ng: 21±2%; BPA-5mg: 21±2%; OIL: 36±2%) and increase of atretic follicles (BPA-25ng: 24±4%; BPA-5mg: 26±6%; OIL: 15±1%). GnRH secretion measured ex vivo 24h after adult exposure was moderately affected by BPA. Indeed, GnRH interpulse interval was significantly different when comparing animals exposed to the high or low dose of BPA but not when comparingexposed animals to the control group (BPA-25ng: 42.6±0.5; BPA-5mg: 40.2±0.6%; OIL: 41.1±0,2minutes±SEM). In conclusion, while exposure to BPA produces persistent alterations of the estrous cycle after early postnatal exposure, exposure during adulthood appears to cause activational non-persistent alternations of both the estrous cycle and folliculogenesis. [less ▲]

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See detailAdipsic diabetes insipidus revealing a bifocal intracranial germinoma
KREUTZ, Julie ULg; Potorac, Iulia ULg; LUTTERI, Laurence ULg et al

in Annales d'Endocrinologie (2017)

Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the ... [more ▼]

Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice. Le diabète insipide adipsique est une des rares complications des tumeurs intracrâniennes. Il associe une baisse de la sécrétion d’hormone antidiurétique à une perte de la sensation de soif et ilsignale souvent la présence d’une lésion qui atteint ou envahit l’hypothalamus. Nous présentons le cas d’une patiente avec un germinome intracrânien bifocal diagnostiqué devant un tableau de diabète insipide adipsique. À notre connaissance, il s’agit du premier cas de la littérature d’un diabète insipide révélant un germinome intracrânien. La prise en charge des tumeurs germinales intracrâniennes est complexe du fait des phénotypes histologiques divers. Bien que les germinomes ont généralement un meilleur pronostic que les tumeurs non-germinomateuses, ils peuvent avoir des présentations sévères. Le diabète insipide adipsique est une de ces présentations sévères et sa rareté peut rendre son diagnostic et sa prise en charge difficiles. La reconnaissance de cette entité potentielle est, dès lors, importante pour la pratique clinique [less ▲]

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See detailAIP mutations and gigantism
Rostomyan, Liliya ULg; Potorac, Iulia ULg; BECKERS, Pablo ULg et al

in Annales d'Endocrinologie (2017)

AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated ... [more ▼]

AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤ 30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities. Bien que les mutations du gène AIP soient rares dans les cas d’acromégalie sporadique, l’importance de ces mutations est établie dans des populations spécifiques de patients telles que les patients qui souffrent de familial isolated pituitary adenomas (FIPA), de gigantisme ou qui présentent un macroadénome hypophysaire avant l’âge de 30 ans. C’est dans le gigantisme qu’elles sont le plus fréquemment retrouvées (29 % des géants présentent une mutation de ce gène). Dans ces populations, nos données suggèrent qu’il est utile de réaliser un screening ciblé pour les mutations ou délétions du gène AIP. La reconnaissance précoce des cas d’acromégalie et de gigantisme permet une évaluation clinique et un traitement appropriés de ces patients. Elle contribue à améliorer les résultats des traitements tant en terme de croissance excessive qu’en ce qui concerne les comorbidités liées à l’acromégalie. [less ▲]

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See detailCow milk coagulation: process description, variation factors and evaluation methodologies. A review.
Troch, Thibault; Lefebure, Emilie ULg; Baeten, Vincent et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21

Introduction. For dairy producers who want to transform their milk, the ability of milk to coagulate is an important parameter. It makes it possible to transform milk into cheese. Therefore, it is ... [more ▼]

Introduction. For dairy producers who want to transform their milk, the ability of milk to coagulate is an important parameter. It makes it possible to transform milk into cheese. Therefore, it is necessary to understand the coagulation process and the techniques to measure it in order to achieve the best transformation performance. The objective of this review is to describe the milk coagulation process, the factors influencing it and the methods for measuring the coagulation of milk at lab level. Literature. The processing of milk into cheese involves three steps: coagulation, dewatering and refining. Coagulation is a key step which involves the use of rennet and depends on several parameters (pH, calcium content, temperature, etc.). Some milks never coagulate. To measure the coagulation ability of milk and identify different parameters in milk coagulation properties, the Formagraph, the computerized renneting meter and the Optigraph have been developed (reference methods). Equations have been developed using infrared spectrometry to predict the parameters obtained by the reference methods. Conclusions. The milk coagulation mechanism is known. However, the issue of non-coagulating milk persists and represents a real challenge in terms of yield. The use of infrared is a faster alternative to reference methods that measure the coagulation properties of milk, but still requires an improvement in prediction equations. [less ▲]

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See detailFunctional emulsion-templated macroporous polymers via controlled radical polymerization
Mathieu, Kevin ULg; Jérôme, Christine ULg; Debuigne, Antoine ULg

Conference (2017, May 05)

Macroporous polymer monoliths with interconnected structures have attracted considerable interest in the fields of supported catalysis, chromatography, water purification, etc. A popular and ... [more ▼]

Macroporous polymer monoliths with interconnected structures have attracted considerable interest in the fields of supported catalysis, chromatography, water purification, etc. A popular and straightforward synthesis approach for such open-cell polymers is based on the emulsion-templated polymerization. In this strategy, a major phase is dispersed in a minor continuous phase containing monomers, cross-linker, initiator and surfactant. The curing of the continuous phase followed by the removal of the dispersed phase leads to a monolith with voids interconnected by pores. Size and number of the latters are influenced by several parameters and especially by the nature of the surfactant. Consequently, we prepared by controlled radical polymerization a series of well-defined amphiphilic copolymers having different hydrophilic-lipophilic balance (HLB) and chain-ends, used it as stabilizers for the emulsion-templated polymerizations and demonstrated the crucial effect of the macromolecular features as well as the concentration on the foam morphology. Secondly, the physical and the chemical anchoring of the macromolecular surfactants at the surface of the pores were also considered for tuning the surface properties of the porous monoliths in one step. This strategy was also implemented with alkyne-terminated copolymers in order to decorate the surface of the cavities with “clickable” moieties which broadens the scope of functional macroporous polymers. [less ▲]

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See detailGérer ses références bibliographiques avec ZOTERO
Cordier, Quentin ULg; Desseilles, François ULg

Scientific conference (2017, May 05)

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See detailMONitOring des flux de POLluants dans les Eaux Souterraines
Jamin, Pierre ULg; Dassargues, Alain ULg; Brouyère, Serge ULg

Poster (2017, May 05)

Contaminated aquifers management is currently based on the evaluation of pollutant concentration in the groundwater. This approach is necessary but totally insufficient to evaluate the risk posed by the ... [more ▼]

Contaminated aquifers management is currently based on the evaluation of pollutant concentration in the groundwater. This approach is necessary but totally insufficient to evaluate the risk posed by the contamination to potential receptors. Since the risk is due to the pollutant that are actually moving, and might reach a receptor, this concentration measurement should be combined to a measurement of the groundwater flow velocity (i.e. the driving force of contaminant migration in aquifers), to quantify the contaminant mass flux at which the receptor is exposed. We propose a new point dilution technique able to measure accurately the groundwater flux and to monitor continuously its changes with time. [less ▲]

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See detailFrom the shortest to the tallest
Beckers, Albert ULg

in Annales d'Endocrinologie (2017), 78

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See detailThe use of stable isotopes in marine animal trophic ecology
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Frederich, Bruno ULg et al

Conference (2017, May 05)

Stable isotope analysis has been recognised as a useful tool for studying animal diet, identifying trophic relationships, and delineating food web structures as well as their alteration by human ... [more ▼]

Stable isotope analysis has been recognised as a useful tool for studying animal diet, identifying trophic relationships, and delineating food web structures as well as their alteration by human activities. Over the past decade, the number of studies using stable isotopes of carbon and nitrogen in marine trophic ecology has increased rapidly as technological advancements greatly facilitate their use. This tool is now among the most popular in ecology and several fields of investigations have developed, including the extension of analyses to more ‘difficult’ stable isotope ratio measurements such as sulfur, the use of isotope mixing models, and the creation of compound-specific stable isotope analysis. Here, we present three case studies taken from our own investigations and previously published literature. The first investigates seagrass detritus ecosystem in which the coexistence of a rich number of species of crustacean raises the question of whether trophic diversity exist among these species. The second examines the feeding habits of coral reef fish and explores whether habitat choice on the reef and their behaviour emerges as good predictors of diet. The third presents the potential use of stable isotope analysis in studying the nutrition of scleractinian corals, which are complex symbiotic organisms that usually present both autotrophic and heterotrophic pathways. This tool has enhanced our understanding of coral species biology, yet it remains underused. Overall, we aim to provide initial insights into stable isotope analysis for illustrating their utility and potential applications to better understand food web structures and species diet in the waters around Taiwan. [less ▲]

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See detailDie Geheimnisse der Natur
Haler, Jean ULg; Schülke, Sophia; De Pauw, Edwin ULg

Article for general public (2017)

Detailed reference viewed: 29 (2 ULg)
See detailTo be plastic is fantastic: delineate coral species niches for assessing their tolerance to changes
Denis, Vianney; Sturaro, Nicolas ULg; Yang, Shan-Hua et al

Conference (2017, May 05)

Climatic and anthropogenic disturbances alter coral reefs by reconfiguring existing coral assemblages. Surviving species are selected by the new environment based on particular traits that they may ... [more ▼]

Climatic and anthropogenic disturbances alter coral reefs by reconfiguring existing coral assemblages. Surviving species are selected by the new environment based on particular traits that they may exhibit, with the plasticity in traits defining ecological strategies associated with contrasting degrees of tolerance to changes. In this process, specialists are expected to tolerate few changes to the environmental conditions and are restricted to specific habitat, while generalists can cope with a wider range of environmental conditions by readjusting traits according to the habitat’s features. Ecological strategies in corals have been exclusively defined according to species’ trait averages, irrespective of individual variations. Challenges representing the acquisition and use of energy have also tended to be oversimplified, specifically by the choice of easy traits in the absence of strong scientific evidence. In this study, we propose a re-examination of strategies in scleractinian corals by focusing on the intraspecific variation of traits. We will investigate how the characteristics of a given species niche can help coral species to tolerate changes. Our multidisciplinary approach will focus on three major characteristics of the coral holobiont (its physiology, trophic ecology, and associated microbiome) which together can define the ecological plasticity of species. This work is of tremendous importance for enhancing the understanding of coral response to environmental changes and for ensuring functions as well as the services of this ecosystem to future generations. [less ▲]

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See detailUnusually high sea ice cover influences resource use by benthic invertebrates in coastal Antarctica
Michel, Loïc ULg; Dubois, Philippe; Eleaume, Marc et al

Conference (2017, May 04)

Antarctica currently undergoes strong and contrasted impacts linked with climate change. While the West Antarctic Peninsula is one of the most rapidly warming regions in the world, resulting in sea ice ... [more ▼]

Antarctica currently undergoes strong and contrasted impacts linked with climate change. While the West Antarctic Peninsula is one of the most rapidly warming regions in the world, resulting in sea ice cover decrease, the sea ice cover of East Antarctica unexpectedly tends to increase, possibly in relation with changes in atmospheric circulation. Changes in sea ice cover are likely to influence benthic food web structure through modifications of benthic-pelagic coupling, disruption of benthic production and/or modifications of benthic community structure (i.e. resource availability for benthic consumers). Here, we studied shallow (0-20 m) benthic food web structure on the coasts of Petrels Island (Adélie Land, East Antarctica) during an event of unusually high spatial and temporal (two successive austral summers without seasonal break-up) sea ice cover. Using stable isotope ratios of C and N and the SIAR mixing model, we examined importance of 4 organic matter sources (benthic macroalgae, benthic biofilm, sympagic algae, suspended particulate organic matter) for nutrition of dominant primary consumers and omnivores. 14 invertebrate taxa including sessile and mobile polychaetes, gastropods, bivalves, sea stars, sea urchins and sea cucumbers were studied. Our results indicate that most benthic invertebrates predominantly relied on sympagic algae. Despite its very high abundance, trophic role of benthic biofilm seemed limited. However, interpretation of data was complicated by the peculiar ecophysiological features of Antarctic invertebrates, whose very low metabolic rates could be associated to low isotopic turnover and long time to reach isotopic equilibrium with their food items. Resource use by consumers from Adélie Land markedly differed from literature data about invertebrate diet in coastal Antarctica, suggesting 1) important influence of increased sea ice cover on benthic food web structure and 2) high spatial and/or temporal variation in the feeding habits of studied organisms, likely linked with a high degree of trophic plasticity. Our results provide insights about how Antarctic benthic consumers, which have evolved in an extremely stable environment, might adapt their feeding habits in response to sudden man-driven changes in environmental conditions and trophic resource availability. [less ▲]

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See detailControlled synthesis of α-olefins-based copolymers by organocobalt(III) complexes
Demarteau, Jérémy ULg; Debuigne, Antoine ULg; Detrembleur, Christophe ULg

Conference (2017, May 04)

Polyolefins, and ethylene-vinyl acetate (EVA) copolymers in particular, are highly attractive materials that are industrially synthesized by a free radical process for large range of applications from ... [more ▼]

Polyolefins, and ethylene-vinyl acetate (EVA) copolymers in particular, are highly attractive materials that are industrially synthesized by a free radical process for large range of applications from food packaging to coatings. Their production requires drastic synthesis conditions (high pressure and high temperature) and the resulting polymers are generally ill-defined. Controlling the polymerization of these unconjugated monomers remains however extremely difficult because of the lack of stabilizing group on their double bond. Moreover, the preparation of chain-end functionalized polyolefins is actually impossible under these conditions. This communication aims at reporting an efficient platform for the precision design of alpha-olefin-based copolymers through a controlled radical polymerization technique called Cobalt-Mediated Radical Polymerization (CMRP). The latter is based on the reversible deactivation of the radical chains by a cobalt complex bearing acetylacetonate (acac) ligands, which is very efficient under mild experimental conditions. The presentation will focus on three main axes: (i) the synthesis of a novel organocobalt(III) complex useful for the functionalization of the polymer chains, (ii) the preparation of various EVA architectures, (iii) the controlled copolymerization of vinyl acetate with a perfluorinated alkene, i.e. perfluorohexylethylene. The hydrolysis of the pendent esters moieties of these fluorinated copolymers paved the way to their polyvinylalcohol counterparts with a marked amphiphilicity. [less ▲]

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See detailAspects économiques de la traduction et circulation d'oeuvres philosophiques
Neelsen, Sarah ULg

Speech/Talk (2017)

Dans un entretien croisé d'une heure et demie, le libraire liégeois Olivier Verschueren et la traductrice argentine Patricia Willson présenteront leur travail et leur contribution quotidienne à la ... [more ▼]

Dans un entretien croisé d'une heure et demie, le libraire liégeois Olivier Verschueren et la traductrice argentine Patricia Willson présenteront leur travail et leur contribution quotidienne à la circulation des œuvres philosophiques. Ils évoqueront le marché du livre, le profil des publics et le renouvellement du paysage éditorial, ainsi que la prise de risque qui préside à toute introduction d'une œuvre philosophique nouvelle, tout particulièrement quand elle provient d'un contexte culturel différent. L'accent sera également mis sur les conditions matérielles de la traduction. [less ▲]

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See detailQualifier Trump de malade mental : un manque de respect pour les malades mentaux
Englebert, Jérôme ULg

Article for general public (2017)

Detailed reference viewed: 25 (1 ULg)