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See detailAn orphan GPCR may be mutated in patients with Cushing Disease
Correa, RR; Trivellin, G; Li, Y et al

in Abstract book - ENDO 2015 (2015, March)

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See detailPostface aux Nouvelles du Grand Possible et autres récits de Marcel Thiry
Durand, Pascal ULg

in Nouvelles du Grand Possible et autres récits (2015)

Nouvelle édition revue et complétée des Nouvelles du Grand Possible de Marcel Thiry (et seconde édition dans la collection patrimoniale « Espace Nord »). La Postface et les annexes bio-bibliographiques ... [more ▼]

Nouvelle édition revue et complétée des Nouvelles du Grand Possible de Marcel Thiry (et seconde édition dans la collection patrimoniale « Espace Nord »). La Postface et les annexes bio-bibliographiques ont été fortement revues et complétées pour la présente édition, enfin conforme à l'édition originale de l'oeuvre ainsi qu'aux intentions ultérieures de son auteur. [less ▲]

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See detailMultitasking abilities in persons diagnosed with schizophrenia: a new tool and cognitive model.
Laloyaux, Julien ULg; Van der Linden, Martial ULg; Laroi, Frank ULg

in Schizophrenia Bulletin (2015, March), 41(Supplement 1),

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia, and in particular during multitasking activities (Semkovska et al., 2010). Multitasking refers to ... [more ▼]

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia, and in particular during multitasking activities (Semkovska et al., 2010). Multitasking refers to activities (e.g. preparing a meal) where the person has to: (a) carry out and alternate between different tasks that vary in terms of priority, difficulty and duration; (b) define the tasks’ targets; (c) and where the person is faced with unexpected problems during the realization of these tasks (Burgess, 2000). However, the cognitive underpinnings of multitasking abilities have never been adequately explored in schizophrenia. Further, only two cognitive models exist in the literature, which are based on student (Logie et al., 2011) and neurological (Burgess et al., 2000) samples. Both of these models suggest three primary constructs: Memory, Planning and Intent. There are, however, several limitations related to the way multitasking abilities were evaluated in these studies. We thus developed a computerized real-life activity task - the Computerized Meeting Preparation Task (CPMT), which was specifically designed to take into account the multitasking nature of certain everyday life activities. Using this task, and based on previous studies (Burgess et al., 2000; Logie et al., 2011), the aim of the present study was to evaluate multitasking abilities in schizophrenia and to do so in a new cognitive model of multitasking that takes into account certain cognitive functions that are not integrated in existing models. Methods: Fifty-seven individuals with schizophrenia and 41 matched healthy controls completed the CMPT. Participants were also evaluated with a battery of cognitive tests. Results: The results suggest that the CMPT possesses good sensitivity and confirmed the three underlying constructs of multitasking (Memory, Planning and Intent), which were found to be underpinned by several cognitive functions and multitasking aspects. Conclusion: Taken together, this new cognitive model and the CMPT could be a good basis for cognitive interventions of multitasking abilities in schizophrenia. Burgess, P.W., 2000. Strategy application disorder: the role of the frontal lobes in human multitasking. Psychol Res 63, 279-288. Logie, R., et al., 2011. Multitasking: multiple, domain-specific cognitive functions in a virtual environment. Mem Cogn 39, 1561-1574. Semkovska, M. et al., 2004. Assessment of executive dysfunction during activities of daily living in schizophrenia. Schizophr Res 69, 289-300. [less ▲]

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See detailControl of plankton phenology by climate variation in a Mediterranean coastal area : results from a long-term study (1979-2011)
Goffart, Anne ULg; Collignon, Amandine ULg; Hecq, Jean-Henri ULg

Conference (2015, March)

Physical processes are known to play major roles in marine plankton succession. However, few studies have addressed the mechanisms that regulate phyto- and zooplankton phenology in a context of changing ... [more ▼]

Physical processes are known to play major roles in marine plankton succession. However, few studies have addressed the mechanisms that regulate phyto- and zooplankton phenology in a context of changing climate. Here we used a unique long-term (1979-2011) time series performed in a Mediterranean coastal area unbiased by local anthropogenic pressure (PHYTOCLY station, Bay of Calvi, Corsica) to understand how environmental forcing affects the timing, duration and magnitude of the winter-spring phyto- and zooplankton blooms. We showed that phyto- and zooplankton blooms were bottom-up controlled by the establishment of favourable abiotic conditions, i.e. nutrient replenishment by vertical mixing under specific water temperature and wind conditions, for which thresholds were defined. According to the intensity of winter characteristics, there were strong differences in both the abundance and composition of phyto- and zooplankton during the winter-spring period. Our study is consistent with the recent reports that, when occurring, diatoms peaks were added to the initial phytoplankton groups instead of replacing them. In contrast, zooplankton groups followed a replacement sequence. Based on the results provided by our time series, we show that plankton phenology in the Bay of Calvi is highly controlled by climate variation and exhibits contrasted patterns in response to different scenarios of environmental forcing. [less ▲]

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See detailDual-use controls outreach: a new method
Michel, Quentin ULg; Paile, Sylvain ULg

in WorldECR (2015), (38), 27-28

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See detailIUVS dayglow analysis
Jain; Evans; Stevens et al

Conference (2015, March)

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See detailInfusion of third-party mesenchymal stream cells after liver transplantation: a phase-1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 29

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed ... [more ▼]

Background: Mesenchymal stromal cells (MSC) are multipotent bone marrow progenitors that have demonstrated significant immunosuppressive effects in various in vivo and in vitro studies. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. This study aimed to be the first evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled phase-1 study. Patients & Methods: Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post-operative day 3±2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. Results: No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. Discussion: This phase 1 study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

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See detailMetabolomic, proteomic and preclinical imaging of patient-derived tumor xenografts for improving treatment of liver metastases patients
Perez Palacios, A; Blomme, A; Boutry, S et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 134

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See detailExpel: a novel non-destructive method for mining soluble tumor biomarkers
Costanza, B; Blomme, A; MUTIJIMA NZARAMBA, Eugène ULg et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 13

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See detailAnalysis of Martian nightglow and aurora
Stiepen, Arnaud ULg

Conference (2015, March)

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See detailAutoimmune thyroid diseases in early childhood three case reports
GUFFINS, A; HARVENGT, Julie ULg; LUYCKX, F et al

Poster (2015, March)

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See detailStakeholder incentives and aid effectiveness: A case study in the health district of Kayes in Mali
Devahive, Eva; Paul, Elisabeth ULg; Samaké, Salif et al

in Journal of Development Studies (2015)

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar ... [more ▼]

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar degree. Most projects have limited impact on health services, but many programmes supported by donors offer positive opportunities for health system strengthening. The representations of different categories of stakeholders diverge – notably, regarding the role of different actors in service provision. A number of consistent strategic logics influence actors’ behaviour. We show that while many donors have committed at global level to respect aid effectiveness principles, implementation lags behind. [less ▲]

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See detailImpact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in Journal de Traumatologie du Sport (2015), 32(1), 41-45

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a ... [more ▼]

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a bleeding arising during the daily brushing? Being not painful, it activates very often no concern and no request of consultation. It is nevertheless about one of the most obvious clinical signs of the periodontal diseases which affect, to varying degrees, practically 90 % of the population in France in all groups of ages and is responsible of the loss from 30 to 40 % of the teeth. For several decades, the scientific world admits a relation between the periodontal disease and certain systematic diseases, as the endocarditis, the atherosclerosis, the diabetes… And what about tendinopathies? Their appearance is often spontaneous without specific medical origin and their cure turns out long and painful. This review has for objective to highlight the relations between the oral hygiene and sportsmen. [less ▲]

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See detailDesign and implementation of a ‘physical activity day’ for overweight and obese youth
Cloes, Marc ULg; DEWANDRE, Anne-Cécile ULg; LEBRETHON, Marie-Christine ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, March), 17(1),

This study aimed to analyze the development and implementation of an adapted physical activity day expected to underline to overweight/obese youth the role of PA and hw they could be more active in their ... [more ▼]

This study aimed to analyze the development and implementation of an adapted physical activity day expected to underline to overweight/obese youth the role of PA and hw they could be more active in their daily life. [less ▲]

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See detailChirurgie de l'atrésie anale du veau
Arengi, Ada; Sartelet, Arnaud ULg

in Point Vétérinaire (2015), 353

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See detailCompte rendu de Ulrich Herbert, Geschichte Deutschlands im 20. Jahrhundert
Brüll, Christoph ULg

in Wissenschaftlicher Literaturanzeiger [=WLA] (2015)

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