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See detailCaractérisation ontogénique, phénotypique et fonctionnelle des macrophages interstitiels pulmonaires après exposition à des composés bactériens
Sabatel, Catherine ULiege

Doctoral thesis (2017)

Respiratory mucosal surfaces are continuously exposed to harmless antigens and immunostimulatory molecules of microbial origin. According to the « self/non self » and « danger » theories, this should ... [more ▼]

Respiratory mucosal surfaces are continuously exposed to harmless antigens and immunostimulatory molecules of microbial origin. According to the « self/non self » and « danger » theories, this should normally result in the developpment of unwanted immune responses towards these inhaled antigens such as Th2-mediated allergic responses. This is however not the case in most people. The hygiene hypothesis postulates that living in an environment rich in microbial components paradoxically protects from airway allergy, implying the existence in the lung of suppressive mechanisms triggered by these immunogenic signals. In this study, we showed that synthetic bacterial DNA rich in unmethylated CpG motifs (CpG) has the unique ability to significantly increase the population of lung interstitial regulatory macrophages (IM) from CCR2-independent monocytes residing in the lung or mobilized from the spleen. Moreover these CpG-induced IM demonstrated a hypersuppressive profile as they produced more IL-10 than their steady state counterparts. Using mice models of airway allergy we showed that the transfert of IM isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. This IM-mediated protection was dependant from IL-10 as CpG-induced Il10-/- IM had no protective effect. The expansion of pulmonary regulatory IM from CCR2-independent pulmonary and splenic monocytes upon CpG exposure could be a possible mechanism by which exposure to an environment rich in microbial products protects against asthma. [less ▲]

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See detailAnomalies des gonadotrophines LH et FSH: tableaux cliniques
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2017, November 14)

L’hormone lutéinisante (LH) et l’hormone folliculostimulante (FSH) – hormones glycoprotéiques hypophysaires – régulent de concert la production de stéroïdes sexuels et la reproduction. Les stéroïdes ... [more ▼]

L’hormone lutéinisante (LH) et l’hormone folliculostimulante (FSH) – hormones glycoprotéiques hypophysaires – régulent de concert la production de stéroïdes sexuels et la reproduction. Les stéroïdes sexuels sont indispensables à la virilisation et à la féminisation, et participent également à la gamétogenèse (spermatogenèse chez l’homme et folliculogenèse chez la femme). Cette présentation fait le point sur la physiologie et la pathologie de LH et de FSH en reproduction humaine. [less ▲]

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See detailQuels futurs pour la fabrication de pièces métalliques ?
Habraken, Anne ULiege; Delvenne, Pierre ULiege; Elsen, Catherine ULiege

Conference given outside the academic context (2017)

Les processus de fabrication des pièces métalliques sont au cœur de nombreux enjeux technologiques, sociopolitiques et économiques. Ces dernières années, des procédés tels le 3D Printing ou encore le ... [more ▼]

Les processus de fabrication des pièces métalliques sont au cœur de nombreux enjeux technologiques, sociopolitiques et économiques. Ces dernières années, des procédés tels le 3D Printing ou encore le formage incrémental ont apporté un renouveau possible face aux méthodes de fabrication traditionnelles. Si le premier est, à présent, bien connu du grand public, le formage incrémental mérite encore quelques explications. Ce procédé, relativement lent, est de mieux en mieux maîtrisé. Il permet de réaliser des pièces métalliques aussi diverses qu’une prothèse, un panneau de façade ou de porte de boeing, un évier de cuisine, ... Il comporte de multiples variantes et est progressivement exploité par l’industrie pour du prototypage de pièces uniques et des petites séries. A l’ère de la révolution numérique, où les Fablabs, Repair Cafés et autres Hackers Labs permettent aux citoyens de créer leurs propres pièces et de devenir acteurs de l’innovation, ce procédé ouvre ainsi de nouvelles portes pour la conception de pièces métalliques. [less ▲]

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See detailOut of hospital neonatal resuscitation: a control randomised study
Servotte, Jean-Christophe ULiege; Ghuysen, Alexandre ULiege; Simonet et al

Conference (2017, November 14)

Introduction : En 2014, 64 accouchements inopinés sont survenus en Wallonie. 5,3% des naissances ont nécessité une réanimation néonatale. Or, de nombreux professionnels de l’urgence terminent leur ... [more ▼]

Introduction : En 2014, 64 accouchements inopinés sont survenus en Wallonie. 5,3% des naissances ont nécessité une réanimation néonatale. Or, de nombreux professionnels de l’urgence terminent leur formation avec une expertise insuffisante dans ce domaine (Nadel et al. 2000). En effet, la réanimation néonatale nécessite des compétences cognitives, techniques et comportementales spécifiques (Halamek et al. 2016). Objectifs : Notre étude randomisée contrôlée a évalué l’impact d’une formation utilisant la simulation clinique sur l’évolution des connaissances et des compétences techniques en réanimation néonatale, avec l’hypothèse que cette méthode a un impact supérieur à l’enseignement clinique traditionnel. Matériel & Méthodes : Des infirmiers se spécialisant en soins intensifs et aide médicale urgente (SIAMU) ont été assignés, après randomisation, à un groupe expérimental (GE) ou à un groupe contrôle (GC). Le GE a reçu un cours théorique suivi d’une formation par simulation (2h) et de 4 semaines de stage. Le GC a reçu un cours théorique suivi de 4 semaines de stage. La population a été évaluée à 2 reprises au moyen d’une simulation de réanimation néonatale et de questionnaires: avant et après la formation, à 4 semaines d’intervalle. Deux experts ont évalué à l’aveugle sur base d’une grille critériée les compétences techniques lors de la simulation. Résultats : 36 participants ont été inclus dans l’étude. Les 2 groupes ont amélioré leurs connaissances. Comparativement, le GE a davantage amélioré ses connaissances globales (p = 0,0001) et spécifiques (p = 0,0007). La formation a permis une amélioration des compétences techniques de 83,3% pour le GC et de 175% pour le GE. Cette différence est significative (p = 0,003). Conclusions : Les deux méthodes pédagogiques ont amélioré les connaissances et les compétences techniques des infirmiers SIAMU. Toutefois, l’impact est significativement supérieur en faveur de la formation utilisant la simulation par rapport à l’enseignement clinique traditionnel. [less ▲]

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See detailThe Vacuum UV Photoabsorption Spectrum of the Geminal Dichloroethylene (1,1-C2H2Cl2) in the 5-20 eV Range. A Vibrational Analysis of the Valence and Rydberg States.
Locht, Robert ULiege; Dehareng, Dominique; Leyh, Bernard ULiege

in Journal of Physics Communications (2017), 1(04), 5013

The vacuum UV photoabsorption spectrum of 1,1-C2H2Cl2 is presented and discussed in detail in the 6 - 20 eV photon energy range. The broad band observed at 6.488 eV includes the 2b1()→σ*, 2b1()→ ... [more ▼]

The vacuum UV photoabsorption spectrum of 1,1-C2H2Cl2 is presented and discussed in detail in the 6 - 20 eV photon energy range. The broad band observed at 6.488 eV includes the 2b1()→σ*, 2b1()→* valence transitions and the 2b1()→3s Rydberg transitions. A quantum chemical calculation analysis is proposed and applied to the intertwined vibrational structure belonging to these transitions. For the →σ* and →* transitions short vibrational progressions are observed, analyzed and tentatively assigned. The →3s Rydberg transition is characterized by a single progression starting at 6.746 eV. The fine structure observed between 7.5 eV and 10.1 eV has been analyzed in terms of vibronic transitions to ns- (δ= 0.89), np- (δ= 0.59 and 0.37) and nd-type (δ= 0.16) Rydberg states all converging to the 1,1-C2H2Cl2+( 2B1) ionic ground state. The vibrational structure analysis excitation leads to the following wavenumbers: ω2≈ 1310 cm-1 (162 meV), ω4≈ 650 cm-1 (81 meV) and ω5≈ 290 cm-1 (37 meV). These modes can be assigned to the C=C stretching, to the symmetric C-Cl stretching and to the symmetric Cl-C-Cl bending vibrations respectively. By the same way, eight other Rydberg states were analyzed. For the first time the vacuum UV spectrum of 1,1-C2H2Cl2 has been recorded in the 10 eV-20 eV range, revealing intense broad bands which are assigned to transitions to Rydberg states converging to excited states of 1,1-C2H2Cl2+. Assignments are also proposed for the vibrational excitations observed in this range. [less ▲]

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See detailEntre piété et faste. Réflexions sur le mécénat artistique des collaborateurs du pape Léon X (1513-1521)
Trizzullo, Eva ULiege

Conference given outside the academic context (2017)

Detailed reference viewed: 15 (3 ULiège)
See detailDrei Sprachen, drei Kulturräume, ein Land : eine Einführung in den belgischen Föderalismus
Behrendt, Christian ULiege

Conference given outside the academic context (2017)

Speech given at a Belgian-German Rotary meeting in Tongeren, Belgium, on November 14, 2017.

Detailed reference viewed: 31 (1 ULiège)
See detailThe Other Self: Some Thoughts on Player-Avatar Relationships
Delbouille, Julie ULiege

Scientific conference (2017, November 14)

Detailed reference viewed: 22 (0 ULiège)
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See detailSowing flower strips in a wheat field to enhance biological control of aphids and support pollinators
Amy, Clara ULiege; Brigode, Mélanie ULiege; Hatt, Séverin ULiege et al

Poster (2017, November 14)

Insect pests are responsible, among other factors, for reducing the productivity of crops. While chemical insecticides used to control them cause harmful effects on human health and the environment ... [more ▼]

Insect pests are responsible, among other factors, for reducing the productivity of crops. While chemical insecticides used to control them cause harmful effects on human health and the environment, conservation biological control, i.e. managing habitats in agricultural landscapes to support pest natural enemies, turns out to be a promising approach. Moreover, the decline of pollinators in agricultural areas is observed since a few decades, being partly due to the intensification of agriculture which homogenizes and degrades agricultural landscape. To reduce the detrimental effects of agricultural intensification on biodiversity, ecosystem functioning and ecosystem services, farmers have the opportunity to adopt agri-environmental measures. Among them, the establishment of flower strips, with a recognized interest in biological control and the conservation of pollinators, is proposed. However, their establishment is not systematically efficient and profitable for the farmers. Adapting mixture composition to farmer’s need may encourage their adoption. Thus, the research project has a double goals (i) to provide intercropping flower strips for promoting the attraction of beneficial insects against pests and for promoting pollinators diversity; and (ii) to suggests diversification of farm income by planting monospecific oilseed flower strips. [less ▲]

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See detailConsommer « local »: un choix environnemental ?
Ozer, Pierre ULiege

Conference given outside the academic context (2017)

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See detailEtude de la transmission du gammaherpèsvirus murin 4: importance de la glycoprotéine gp150 et développement de stratégies antivirales basées sur l'utilisation du cidofovir
Zeippen, Caroline ULiege

Doctoral thesis (2017)

Gammaherpèsviruses are important pathogens in human medicine. Indeed, Epstein Barr virus and Kaposi Sarcoma associated herpesvirus are responsible for numerous lymphoproliferative diseases and cancers ... [more ▼]

Gammaherpèsviruses are important pathogens in human medicine. Indeed, Epstein Barr virus and Kaposi Sarcoma associated herpesvirus are responsible for numerous lymphoproliferative diseases and cancers. Murid Herpesvirus-4 (MuHV-4) is usually used as a model for human gammaherpèsviruses. Until now, the major limitation of this model was the absence of transmission in laboratory animals. Recently, a sexual transmission of MuHV-4 has been described in laboratory mice. This observation allows, on the one hand, to study mechanisms underlying natural transmission, such as cellular trospism, importance of viral proteins, or immunity response during this part of the cycle. On the other hand, this transmission model allows to test efficiency of measures to reduce transmission. Indeed, herpesvirus are archetype of persistant viruses as infection persists lifelong once established. Studying mechanisms underlying transmission and how to use these mechanisms to reduce it efficiently is therefore of primordial importance. In a first study, we focussed on the biological relevance of mechanisms described previously in vitro. Indeed, a MuHV-4 glycoprotein, gp150, has been shown to participate to the release of infectious particles from cells and to evasion of humoral immunity, two functions that could be important for the virus during transmission. Our results showed that gp150 is essential for an efficient sexual transmission of the MuHV-4. Indeed, gp150 promotes the release of infectious particles from infected vaginal epithelial cells. These results has been published in Journal of Virology in July 2017. In a second study, the same model was used to test efficiency of an antiviral molecule to reduce sexual transmission of the MuHV-4. A nucleotide analogue, the cidofovir, was administrated to mice according to different protocols. A daily administration of cidofovir reduced drastically genital shedding, but also prevent completely infection of naive mice after sexual contact. Finally, a single injection of cidofovir, administered 24 hours after sexual contact, reduced significantly transmission. Altogether, in this work, we used a transmission model of a gammaherpèsvirus in two differents studies: the first foccused on glycoprotein implicated during the transmission and established the importance of a single viral glycoprotein for an efficient transmission. The second study highlighted the efficiency of antiviral drugs to prevent infection by gammaherpesviruses. [less ▲]

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See detailThe Physiology of The Thymus
Geenen, Vincent ULiege

Scientific conference (2017, November 13)

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See detailL’expérience des amours infidèles : une forme d’engagement ?
Guillaume, Jean-François ULiege

in SociologieS (2017)

La fin du désir sexuel pour son conjoint, ou son émoussement, expliqueraient, motiveraient ou justifieraient l’infidélité conjugale. La fidélité durerait le temps de l’amour, le temps des émois (inter ... [more ▼]

La fin du désir sexuel pour son conjoint, ou son émoussement, expliqueraient, motiveraient ou justifieraient l’infidélité conjugale. La fidélité durerait le temps de l’amour, le temps des émois (inter)individuels. À la lecture du Grand résumé que Marie-Carmen nous propose, il semble bien que les choses ne sont pas aussi simples que cela. L’abondance des déclinaisons thématiques des amours infidèles et le foisonnement des concepts mobilisés ne peuvent laisser indifférent : il y est question de socialisation, d’identités, d’expérience, de parcours, d’engagement, de marché sexuel ou amoureux, de genre, de secret, de morale, d’éthique, de domination, de violence symbolique, de ressources, etc. [less ▲]

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See detailLe risque dans l’investissement de l’espace extérieur. Une construction culturelle et sociale ?
Razy, Elodie ULiege

Conference given outside the academic context (2017)

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See detailL'économie collaborative
Gautier, Axel ULiege

Conference given outside the academic context (2017)

Detailed reference viewed: 17 (1 ULiège)