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See detailIn vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
Pestieau, Aude ULg; Evrard, Brigitte ULg

in European Journal of Pharmaceutical Sciences (2017), 102

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]

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See detailAmbiguities in gravitational lens models: the density field from the source position transformation
Unruh, Sandra; Schneider, Peter; Sluse, Dominique ULg

in Astronomy and Astrophysics (2017), 601

Strong gravitational lensing is regarded as the most precise technique to measure the mass in the inner region of galaxies or galaxy clusters. In particular, the mass within one Einstein radius can be ... [more ▼]

Strong gravitational lensing is regarded as the most precise technique to measure the mass in the inner region of galaxies or galaxy clusters. In particular, the mass within one Einstein radius can be determined with an accuracy of the order of a few percent or better, depending on the image configuration. For other radii, however, degeneracies exist between galaxy density profiles, precluding an accurate determination of the enclosed mass. The source position transformation (SPT), which includes the well-known mass-sheet transformation (MST) as a special case, describes this degeneracy of the lensing observables in a more general way. In this paper we explore properties of an SPT, removing the MST to leading order, that is we consider degeneracies which have not been described before. The deflection field \ahat(čθ) resulting from an SPT is not curl-free in general, and thus not a deflection that can be obtained from a lensing mass distribution. Starting from a variational principle, we construct lensing potentials that give rise to a deflection field \atilde, which differs from \ahat by less than an observationally motivated upper limit. The corresponding mass distributions from these "valid" SPTs are studied: their radial profiles are modified relative to the original mass distribution in a significant and non-trivial way, and originally axi-symmetric mass distributions can obtain a finite ellipticity. These results indicate a significant effect of the SPT on quantitative analyses of lens systems. We show that the mass inside the Einstein radius of the original mass distribution is conserved by the SPT; hence, as is the case for the MST, the SPT does not affect the mass determination at the Einstein radius. Furthermore, we analyse a degeneracy between two lens models, empirically found previously, and show that this degeneracy can be interpreted as being due to an SPT. Thus, degeneracies between lensing mass distributions are not just a theoretical possibility, but do arise in actual lens modeling. [less ▲]

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See detailA threshold-based weather model for predicting stripe rust infection in winter wheat
El Jarroudi, Moussa ULg; Kouadio, Louis; Bock, Clive et al

in Plant Disease (2017), 101(693-703),

Wheat stripe rust (caused by Puccinia striiformis f. sp. tritici) is a major threat in most wheat growing regions worldwide, which potentially causes substantial yield losses when environmental conditions ... [more ▼]

Wheat stripe rust (caused by Puccinia striiformis f. sp. tritici) is a major threat in most wheat growing regions worldwide, which potentially causes substantial yield losses when environmental conditions are favorable. Data from 1999-2015 for three representative wheat-growing sites in Luxembourg were used to develop a threshold-based weather model for predicting wheat stripe rust. First, the range of favorable weather conditions using a Monte Carlo simulation method based on the Dennis model were characterized. Then, the optimum combined favorable weather variables (air temperature, relative humidity, and rainfall) during the most critical infection period (May-June) was identified and was used to develop the model. Uninterrupted hours with such favorable weather conditions over each dekad (i.e., 10-day period) during May-June were also considered when building the model. Results showed that a combination of relative humidity > 92% and 4°C < temperature < 16°C for a minimum of 4 continuous hours, associated with rainfall ≤ 0.1 mm (with the dekad having these conditions for 5-20% of the time), were optimum to the development of a wheat stripe rust epidemic. The model accurately predicted infection events: probabilities of detection were ≥ 0.90 and false alarm ratios were ≤ 0.38 on average, and critical success indexes ranged from 0.63 to 1. The method is potentially applicable to studies of other economically important fungal diseases of other crops or in different geographical locations. If weather forecasts are available, the threshold-based weather model can be integrated into an operational warning system to guide fungicide applications. [less ▲]

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See detailAn Optical and Infrared Photometric Study of the Young Open Cluster IC 1805 in the Giant H ii Region W4 †
Sung, Hwankyung; Bessell, Michael S.; Chun, Moo-Young et al

in Astrophysical Journal Supplement Series (2017), 230

We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from ... [more ▼]

We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from their location in the various color–color and color–magnitude diagrams, and the presence of Hα emission, mid-infrared excess emission, and X-ray emission. The reddening law toward IC 1805 is nearly normal (R [SUB] V [/SUB] = 3.05 ± 0.06). However, the distance modulus of the cluster is estimated to be 11.9 ± 0.2 mag (d=2.4+/- 0.2 kpc) from the reddening-free color–magnitude diagrams, which is larger than the distance to the nearby massive star-forming region W3(OH) measured from the radio VLBA astrometry. We also determined the age of IC 1805 ({τ }[SUB]{MSTO[/SUB]}=3.5 Myr). In addition, we critically compared the age and mass scale from two pre-main-sequence evolution models. The initial mass function with a Salpeter-type slope of Γ = ‑1.3 ± 0.2 was obtained and the total mass of IC 1805 was estimated to be about 2700 ± 200 {M}[SUB]ȯ [/SUB]. Finally, we found our distance determination to be statistically consistent with the Tycho-Gaia Astrometric Solution Data Release 1, within the errors. The proper motion of the B-type stars shows an elongated distribution along the Galactic plane, which could be explained by some of the B-type stars being formed in small clouds dispersed by previous episodes of star formation or supernova explosions. The optical imaging data in this article were gathered with two facilities: the AZT-22 1.5 m telescope at Maidanak Astronomical Observatory in Uzbekistan and the Canada–France–Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l’Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. [less ▲]

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See detailHow unique is Plaskett's star? A search for organized magnetic fields in short period, interacting or post-interaction massive binary systems★
Nazé, Yaël ULg; Neiner, Coralie; Grunhut, Jason et al

in Monthly Notices of the Royal Astronomical Society (2017), 467

Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have ... [more ▼]

Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have occurred in this system, one may wonder about their potential role in generating magnetic fields. Stokes V spectra collected with the low-resolution FORS2 and high-resolution ESPaDOnS and Narval spectropolarimeters were therefore used to search for magnetic fields in 15 interacting or post-interaction massive binaries. No magnetic field was detected in any of them, with 0 G always being within 2σ of the derived values. For 17 out of 25 stars in the systems observed at high resolution, the 90 per cent upper limit on the individual dipolar fields is below the dipolar field strength of Plaskett's secondary; a similar result is found for five out of six systems observed at low resolution. If our sample is considered to form a group of stars sharing similar magnetic properties, a global statistical analysis results in a stringent upper limit of ∼200 G on the dipolar field strength. Moreover, the magnetic incidence rate in the full sample of interacting or post-interaction systems (our targets + Plaskett's star) is compatible with that measured from large surveys, showing that they are not significantly different from the general O-star population. These results suggest that binary interactions play no systematic role in the magnetism of such massive systems. [less ▲]

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See detailThe Spitzer search for the transits of HARPS low-mass planets. II. Null results for 19 planets
Gillon, Michaël ULg; Demory, B.-O.; Lovis, C. et al

in Astronomy and Astrophysics (2017), 601

Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of ... [more ▼]

Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of objects suitable for detailed characterization. Searching for the transits of the low-mass planets detected by Doppler surveys is a straightforward way to achieve this goal. Indeed, Doppler surveys target the most nearby main-sequence stars, they regularly detect close-in low-mass planets with significant transit probability, and their radial velocity data constrain strongly the ephemeris of possible transits. In this context, we initiated in 2010 an ambitious Spitzer multi-Cycle transit search project that targeted 25 low-mass planets detected by radial velocity, focusing mainly on the shortest-period planets detected by the HARPS spectrograph. We report here null results for 19 targets of the project. For 16 planets out of 19, a transiting configuration is strongly disfavored or firmly rejected by our data for most planetary compositions. We derive a posterior probability of 83% that none of the probed 19 planets transits (for a prior probability of 22%), which still leaves a significant probability of 17% that at least one of them does transit. Globally, our Spitzer project revealed or confirmed transits for three of its 25 targeted planets, and discarded or disfavored the transiting nature of 20 of them. Our light curves demonstrate for Warm Spitzer excellent photometric precisions: for 14 targets out of 19, we were able to reach standard deviations that were better than 50 ppm per 30 min intervals. Combined with its Earth-trailing orbit, which makes it capable of pointing any star in the sky and to monitor it continuously for days, this work confirms Spitzer as an optimal instrument to detect sub-mmag-deep transits on the bright nearby stars targeted by Doppler surveys. The photometric and radial velocity time series used in this work are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A117">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A117</A> [less ▲]

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See detailPeculiar architectures for the WASP-53 and WASP-81 planet-hosting systems★
Triaud, Amaury H. M. J.; Neveu-VanMalle, Marion; Lendl, Monika et al

in Monthly Notices of the Royal Astronomical Society (2017), 467

We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the ... [more ▼]

We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the photometric signals were indeed produced by two transiting hot Jupiters. Our observations also show the presence of additional Doppler signals. In addition to short-period hot Jupiters, we find that the WASP-53 and WASP-81 systems also host brown dwarfs, on fairly eccentric orbits with semimajor axes of a few astronomical units. WASP-53c is over 16 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB] and WASP-81c is 57 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB]. The presence of these tight, massive companions restricts theories of how the inner planets were assembled. We propose two alternative interpretations: the formation of the hot Jupiters within the snow line or the late dynamical arrival of the brown dwarfs after disc dispersal. We also attempted to measure the Rossiter-McLaughlin effect for both hot Jupiters. In the case of WASP-81b, we fail to detect a signal. For WASP-53b, we find that the planet is aligned with respect to the stellar spin axis. In addition we explore the prospect of transit-timing variations, and of using Gaia's astrometry to measure the true masses of both brown dwarfs and also their relative inclination with respect to the inner transiting hot Jupiters. [less ▲]

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See detailAnesthesia Case of the Month
Tutunaru, Alexandru-Cosmin ULg; Sandersen, Charlotte ULg

in Journal of the American Veterinary Medical Association [=JAVMA] (2017), 250(9), 984-987

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See detailGC×GC-(HR)TOFMS : Why we Love it !
Focant, Jean-François ULg

Scientific conference (2017, May)

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See detailGérer le changement: une dynamique multidimensionnelle et participative
Lisein, Olivier ULg

Scientific conference (2017, May)

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See detailWork environment and work-to-family conflict: Mediating role of work investment.
Babic, Audrey ULg; Stinglhamber, Florence; Barbier, Marie ULg et al

Conference (2017, May)

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See detailTesting a general approach to assess the degree of disturbance in tropical forests
Sellan, Giacomo; Simini, Filippo; Maritan, Amos et al

in Journal of Vegetation Science (2017), 28(3), 459668

Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of ... [more ▼]

Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of disturbance? Location: Reserve of Yangambi, northeast region of the Democratic Republic of Congo. Methods: We applied an allometricmodel based on the assumption that a vir- tually undisturbed forest uses all available resources. In this condition, the forest structure (e.g. the tree size distribution) is theoretically predictable fromthe scal- ing of the tree crown with tree height at an individual level. The degree of dis- turbance can be assessed through comparing the slopes of the tree size distribution curves in the observed and predicted conditions. We tested this tool in forest stands subjected to different degrees of disturbance. We inventoried trees >1.3 m in height by measuring the DBH in three plots of 1 ha each, and measured tree height, crownradius and crownlength in a sub-sample of trees. Results: All tree species, independently of the site, shared the same exponents of allometric relationships: tree height vs tree diameter, crown radius vs tree height, crown length vs tree height and consequently crown volume vs tree height, suggesting that similar trajectories of biomass allocation have evolved irrespective of species. The observed tree size distributions appeared to be power laws (excluding the finite size effect) and, as predicted, the slope was steeper in the less disturbed forest (?2.34) compared to the most disturbed (?1.99). The difference in the slope compared to the theoretical fully functional forest (?2.65) represents the metric for assessing the degree of disturbance. Conclusions: We developed a simple tool for operationalizing the concept of ‘disturbance’ in tropical forests. This approach is species-independent, needs minimal theoretical assumptions, the measurement of only a few structural traits and requires a low investment in equipment, time and computer skills. Its simple implementation opens new perspectives for effectively addressing initiatives of forest protection and/or restoration. [less ▲]

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See detailIsokinetic profil of subjects with proximal patellar tendinopathy
Croisier, Jean-Louis ULg; Roberjot, Mathieu; DELVAUX, François ULg et al

in The Future of Football Medicine (2017, May)

Introduction: Proximal patellar tendinopathy is relatively common among sportsmen, even among football players who do repetitive shooting sessions. However, the strength profile of subjects with proximal ... [more ▼]

Introduction: Proximal patellar tendinopathy is relatively common among sportsmen, even among football players who do repetitive shooting sessions. However, the strength profile of subjects with proximal patellar tendinopathies is rarely described and the isokinetic profile remains unknown. Purpose: We aimed to determine the strength profile of subjects suffering from this frequently recurrent pathology. Methods: Forty-three players (29,1±8.5 y.o.; 78.1±11.9kg; 179.3±7.2cm) with chronic proximal patellar tendinopathy confirmed by ultrasounds were recruited. Quadriceps and hamstrings muscular performances of the healthy and pathological side were measured using an isokinetic dynamometer (Cybex Norm) at the concentric speed of 60°/s (C60) and 240°/s (C240) and at the eccentric speed of 30°/s (E30 - only for hamstrings). A visual analogic scale of pain (VAS) has also been used after each isokinetic test in order to associate the level of complaints and the intensity of contractions. Results: The results (Table 1) for the isokinetic tests comparing the healthy (HS) to the pathological side (PS) are significant for the different conditions of contraction and test speeds, as for the results of the VAS associated to those tests (p<0.01). Indeed, pathological limbs had a maximum peak torque for the quadriceps at C60 and at C240 lower than healthy limbs (2.17 ± 0.68 N.m/kg vs 2.47 ± 0.55 N.m/kg, p = 0.0003 and 1.46 ± 0.42 N.m/kg vs. 1.56 ± 0.31 N.m/kg, p = 0.02, respectively); this represents a bilateral difference of 14% for C60 and 7% in C240. In E30, pathological limbs were also weaker than the healthy limbs (2.46 ± 0.91 N.m/kg vs 2.79 ± 0.96 N.m/kg, p = 0.0008) which represents a difference of 13% between healthy and pathological limbs. For the hamstrings of the pathological limbs, we observed a maximum peak torque at C60 and C240 lower than for the hamstrings of the healthy limbs (1.26 ± 0.37 N.m/kg vs. 1.37 ± 0.36 N.m/kg, p = 0.006 and 0.80 ± 0.23 N.m/kg vs 0.85 ± 0.20 N.m/kg, p = 0.04). The bilateral differences of hamstring strength were 8.7% in C60 and 6% in C240. The PS were more painful than the HS (VAS C60: 3.47 ± 2.65 vs 0.20 ± 1.05; p>0.01; VAS C240: 2.83 ± 2.47 vs. 0.68 ± 0.10; p>0.01; VAS E30: 5,26 ± 2.78 vs 0.58 ± 1.93; p>0.01). The difference of pain can be seen especially in eccentric mode. This observation suggest that isokinetic tests, beyond the measure of strength, could represent a pain provocation test, even with a possible pronostic value for the efficacy of treatment. Conclusions: In our study, the isokinetic results of patients with proximal patellar tendinopathy showed a significant difference in strength profile between the HS and the PS as well as VAS associated with each tests. However, the diversity of outcomes recorded in our population suggests that an individualized rehabilitation treatment is probably more relevant than a common protocol for the healing of this tendon pathology. Isokinetic tests can also represent a tool for assessment of treatment planning. Finally, it would seem that isokinetic tests in the eccentric mode on the quadriceps can be a pain assessment tool for the pathological tendon. [less ▲]

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See detailHow to manage a case of ischial tuberosity avulsion fracture?
Tyberghein, Maëlle; Kaux, Jean-François ULg; GODON, Bernard ULg et al

in The Future of Football Medicine (2017, May)

Introduction Apophyseal avulsion fractures of the pelvis are common among teenage football player. Usually, they are the result of a sudden forceful concentric or eccentric contraction of the muscle ... [more ▼]

Introduction Apophyseal avulsion fractures of the pelvis are common among teenage football player. Usually, they are the result of a sudden forceful concentric or eccentric contraction of the muscle attached to the apophysis. Indeed, before ossification, the apophyseal growth cartilage is the weakest point in the musculotendinous unit, making the apophysis vulnerable to injure. Athletes most commonly affected are soccer players when they tackle or shot powerful at goal and gymnasts during floor exercises which imposed sudden and excessive lengthening. Management of these fractures remains unclear. There are no guidelines between conservative and surgical approach even if most publications recommend a surgery if the diastasis exceeds 2cm and a conservative approach on the other hand. Case report A sixteen-year-old high-level player presented at the consultation with right ischial pain. Three months earlier, while he was sprinting, he had felt acute pain opposite the ischial tuberosity which compelled him to stop the training. He had already consulted another physician, who prescribed an X-ray which revealed an avulsion fracture of the ischial tuberosity with a maximal diastasis of 1.9 cm (Fig 1.a.). According to most publications (1,3), surgery is advisable from 2 cm of diastasis. 1.9 cm was within the range between a surgical and a conservative approach, and the conservative one was applied. An isokinetic assessment was planned. It highlighted hamstring strength imbalances with bilateral difference of 31% in concentric strength and 28% in eccentric strength in comparison with the healthy side. The mixed ratio of the hamstrings in eccentric mode at 30°/s to quadriceps in concentric mode at 240°/s was decreased to 0.8, while the lower limit in our clinical practice corresponded to 0.9. The patient was not allowed to resume competition and a rehabilitation by specific and progressive strengthening in both modes of contraction was initiated; in particular the eccentric training was initially submaximal and progressively intensified. Six weeks later, isokinetic assessment was repeated and showed significant improvement of right hamstring strength, particularly for eccentric contraction. The greatest improvement was the mixed Hecc/Qconc ratio wich had increased from 0.8 to 1.44. In regard to radiology, we observed no change since the previous X-Ray (Fig 1.b.). Intensified training on the field was allowed in order to resume competition. Less than one year after the injury, the patient restarted competition successfully with performance levels which were almost the same as before the injury. Discussion Many publications have discussed the surgical versus the conservative approach to treating ischiatic avulsion. Most of the published literature advocate the relevance of surgery when the diastasis exceeds 2 cm because widely displaced fractures may lead to chronic symptomatology if the treatment remains conservative. Different criteria, such as pain relief, ability to perform in sport, gross strength, activity score, X-Rays, are used by authors to demonstrate the recovery after treatment. No study accurately measured the hamstring strength before and after treatment. However, strength imbalance, especially as regards the H/Q mixed ratio, significantly increases the risk of sustaining hamstring injury in soccer player (2). For our patient, the rehabilitation enabled him to re-establish hamstring strength in six weeks with substantial improvement of eccentric assessment. The mixed Hecc/Qconc ratio increased from 0.8 to 1.44. This improvement significantly decreased the risk of recurrence of hamstring injury. Regarding X-Ray imagery, there was no evidence of healing. We advocate that radiological assessment should not be the main recovery criterion and that specific strengthening should be started even when avulsion persists on the X-Ray. Furthermore, hamstring strength should be measured accurately and objectively, e.g. by isokinetism, to be one of the main return to play criterion in association with clinical data. [less ▲]

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See detailImpact on athletic performance of an early return to play following an ACL rupture
Duval, Thomas; LEHANCE, Cédric ULg; DANIEL, Christophe ULg et al

in The Future of Football Medicine (2017, May)

Introduction and purpose: The rupture of the anterior cross ligament (ACL) is the most frequent knee injury incurred during participation in sports and especially in football. Typically, the injured ... [more ▼]

Introduction and purpose: The rupture of the anterior cross ligament (ACL) is the most frequent knee injury incurred during participation in sports and especially in football. Typically, the injured athlete must undergo a surgical reconstruction of the ligaments followed by a lengthy rehabilitation period. However, the timeline for return to competition after this operation remains a challenge. More than one third of the athletes are unable to go back to sport performing at the same level prior to the injury. Approximately 65% of patients who experience this injury are able to return to sport at the same level. The fear of undergoing a new accident remains a major hurdle with this sporting recovery and the persistence of functional deficits is the first cause of repetitive ligament injuries. A reathletization program guided by strength and conditioning coaches results in a greatly reduces the risk of recurring injury by approximately 66% Methods: Our study involved a randomized control test. Our sample included ten subjects, five in the experimental group and five in the control group. Beginning one month post-surgery, the first group participated in weekly reathletization session beginning one week post-operation, associated with rehabilitation in classical physiotherapy, over a period of six months. The second participated solely in standard physiotherapy. Both groups were subjected to an initial isokinetic test as a base measurement to track improvement. After six months, the subjects of the two groups were evaluated using the following tools: an isokinetic test, a questionnaire of KOOS and finally a Hop tests. Results: The analysis of the isokinetic test and the questionnaire of KOOS ( p= 0.30) enabled us to note differences between the two groups using quantified values; however, the results were significant. On the other hand, the analysis of the results obtained through the functional tests showed significant differences between the two groups, highlighting the increased performance and benefit for the group participating in weekly reathletization. The experimental group displayed results in the three jump tests which indicates a greater strength and recovery. For the single hop test and the triple hop, the result is p = 0.04, and for the cross over test, the result is p = 0.02. Conclusion: In our preliminary study, the quantified values for both groups indicated a greater improvement in the performances of the experimental group reathletization. Although during the statistical analysis and especially in the isokinetic test, few elements significantly evolved to see any for the questionnaire KOOS. The preliminary analysis warrants an experiment involving a larger subject pool be completed. A reathletisation program beginning one month after operation has been found to limit the nuisances and long period of inactivities (weight increase, losses of muscular force, decrease of aerobic performances) typically experienced by those who rupture the ACL. This program has been found to be especially effective when coupled with regular physiotherapy meetings. [less ▲]

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See detailPRTEE et épicondylite
Janssen, Arnaud; Kaux, Jean-François ULg

in Kinésithérapie du Sport Information (2017), (2ème trimestre 2017), 4-7

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See detailPlatelet-rich plasma versus hyaluronic acid to treat patellar tendinopathies
Kaux, Jean-François ULg; Roberjot, Mathieu; SAMSON, Antoine ULg

in The Future of Football Medicine (2017, May)

Introduction: The treatment of patellar tendinopathies could be difficult. This is the reason why new treatments have been developed, among which platelet rich plasma (PRP) injections. Some clinical ... [more ▼]

Introduction: The treatment of patellar tendinopathies could be difficult. This is the reason why new treatments have been developed, among which platelet rich plasma (PRP) injections. Some clinical series have previously evaluated the effect of PRP in the treatment of proximal patellar tendinopathies. Recent systematic review concluded that PRP could be recommend as a treatment in such indication (1). Recently, the viscoelastic properties of hyaluronic acid (HA) on liquid connective tissue have been proposed for the treatment of tendinopathies (2). Some fundamental studies show encouraging results on HA’s ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical setting to improve pain and function. Purpose: We aimed to compare the effect of PRP injection versus two injections of HA after three months on patients who have a proximal patellar tendinopathy. Methods: Eleven leisure football players with proximal patellar tendinopathies being not relieved after minimum three months of physiotherapy treatments where included. Six of them (group 1: 29.5±9.9 y.o.; 78.9±12.8kg; 177.4±6;9cm) have received a leukocyte poor PRP injection (obtained using an aphaeresis machine) under US guidance. This technique of PRP collection enable to obtain reproducible pure PRP with the same chosen concentration of 850 000 platelets/microliter. The other five subjects (group 2: 29.3±8.1 y.o.; 77.1±10.6kg; 178.1±5.8cm) received two HA 2% (40mg/2mL) injections (2mL) at one week apart. All of them have benefited of standardized rehabilitation, 3 times a week. Concerning the evaluation of the pathology, algo-functional tests (visual analogic scale (VAS), pressure algometer, IKDC score, VISA-P score), isokinetics (Cybex Norm; concentric 60°/s (C60), concentric 240°/s (C240) and eccentric 30°/s(E30)) associated to VAS, along with the patellar tendon ultrasonography (US) have been realized over three times (pre-injection, after 6 weeks, after 3 months post-injections). Results: The results of VAS (p<0,01), algometric scores (p<0,01), IKDC scores (p<0,01) and VISA-P (p<0,01) show a considerable improvement in the two groups, but not for the US findings. For the group 1 (Table 1), isokinetic tests show significant results for the hamstrings in C60°/s with an improvement of maximum peak torque (p=0,01) for the pathological limb, a diminution (p>0,05) for the healthy limb and during the analysis of the bilateral difference (p=0,0002). For the group 2, the improvement of quadriceps maximum peak torque in C240°/s is significant (p>0,01) for the pathological knee after 6 weeks post-injections only. The VAS associated with isokinetic tests decreases significantly for all contraction modes after three months of study. Conclusions: Both PRP and HA can improve the symptoms of proximal patellar tendinopathy, even if the results are slightly better in the PRP group. [less ▲]

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See detailFinite element model reduction for space thermal analysis
Jacques, Lionel ULg; Béchet, Eric ULg; Kerschen, Gaëtan ULg

in Finite Elements in Analysis and Design (2017), 127

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]

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