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See detailMultiple analyses of microbial communities applied to the gut of the wood-feeding termite Reticulitermes flavipes fed on artificial diets
Tarayre, Cédric ULg; Bauwens, Julien ULg; Mattéotti, Christel et al

in Symbiosis (2015)

The purpose of this work was the observation of the differences between the microbial communities living in the gut of the termite Reticulitermes flavipes fed on different diets. The termites were fed on ... [more ▼]

The purpose of this work was the observation of the differences between the microbial communities living in the gut of the termite Reticulitermes flavipes fed on different diets. The termites were fed on poplar wood (original diet) and artificial diets consisting of crystalline cellulose (with and without lignin), α-cellulose (with and without lignin) and xylan. The termites were then dissected and the protist communities were analyzed through microscopy, leading to the conclusion that protist species are strongly influenced by diets. BIOLOG ECO Microplates® were used to assess the metabolic properties of the different types of consortia, highlighting strong differences on the basis of principal component analysis and calculation of similarity rates. The microorganisms were cultivated in liquid media corresponding to the artificial diets before being characterized through a metagenetic analysis of gut microbiota (16S ribosomal DNA). This analysis identified several phyla: Acidobacteria, Actinobacteria, Bacteroidetes, Cyanobacteria, Fibrobacteres, Firmicutes, Nitrospirae, OP9, Planctomycetes, Proteobacteria, Spirochaetes, TM6, Tenericutes, Verrucomicrobia and WS3. The OTUs were also determined and confirmed the abundance of Proteobacteria, Bacteroidetes, Firmicutes and Verrucomicrobia. It was possible to isolate several strains from the liquid media, and one bacterium and several fungi were found to produce interesting enzymatic activities. The bacterium Chryseobacterium sp. XAvLW produced α-amylase, β-glucosidase, endo-1,4-β-D-glucanase, endo-1,4-β-D-xylanase and filter paper-cellulase, while the fungi Sarocladium kiliense CTGxxyl and Trichoderma virens CTGxAviL generated the same activities added with endo-1,3-β-D-glucanase. [less ▲]

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See detailFunctional analysis of FRD3 in Arabidopsis
Scheepers, Maxime ULg; Charlier, Jean-Benoit ULg; Spielmann, Julien ULg et al

Poster (2015, June)

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. The FRD3 (FERRIC REDUCTASE DEFECTIVE 3) protein, a member of the MATE family of ... [more ▼]

Zinc and iron are two essential micronutrients for plants. The homeostasis networks of the two metals are intertwined. The FRD3 (FERRIC REDUCTASE DEFECTIVE 3) protein, a member of the MATE family of membrane transporters, is a citrate transporter involved in iron homeostasis and playing a role in zinc tolerance in Arabidopsis. The FRD3 gene displays a complex regulation. Alternative transcript initiation for FRD3 determines two transcripts, which differ in their 5'UTRs and have differential translation efficiency. The two transcripts are selectively regulated under stress conditions: iron and zinc depletion, zinc excess or cadmium presence. We are aiming to determine the FRD3 function in zinc and iron homeostasis in Arabidopsis. We will present data (i) on the functional characterization of the alternative transcripts and their role in metal homeostasis in Arabidopsis and (ii) on the zinc phenotypes of the frd3 mutant. [less ▲]

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See detailEmpowering NGS technologies for the study and diagnostic of plant viruses - European COST Action FA1407
Massart, Sébastien ULg; Gentit, Pascal; Olmos, Antonio et al

Poster (2015, June)

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See detailArno Geiger: Tout sur Sally
Houscheid, Karin ULg

Article for general public (2015)

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See detailThe International Journal of Learning in Higher Education
Noiroux, Kevin ULg

in International Journal of Learning in Higher Education (2015), 22

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See detailPharmacokinetics and clinical evaluation of the alogliptin plus pioglitazone combination for type 2 diabetes.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2015), 11(6), 1005-20

INTRODUCTION: Type 2 diabetes is a complex disease with multiple defects, which generally requires a combination of several pharmacological approaches to reach glucose control targets. A unique fixed-dose ... [more ▼]

INTRODUCTION: Type 2 diabetes is a complex disease with multiple defects, which generally requires a combination of several pharmacological approaches to reach glucose control targets. A unique fixed-dose combination combines a thiazolidinedione (pioglitazone) and a dipeptidyl peptidase-4 inhibitor (alogliptin). Area covered: An extensive literature search was performed to analyze the pharmacokinetics of pioglitazone and alogliptin when used separately and in combination as well as to summarize clinical and toxicological considerations about the combined therapy. Expert opinion: Pioglitazone, a potent insulin sensitizer, and alogliptin, an incretin-based agent that potentiates post-meal insulin secretion and reduces glucagon secretion, have complementary mechanisms of action. The clinical efficacy of a combined therapy is superior to any single therapy in patients treated with diet or with metformin (with or without sulphonylurea). These two drugs can be administered once daily, with or without a meal. No clinically relevant pharmacokinetic interactions between the two agents have been described and the fixed-dose combination has shown bioequivalence with alogliptin and pioglitazone given separately. Combining alogliptin with pioglitazone does not alter the safety profile of each compound. Weight gain observed with pioglitazone may be limited with the addition of alogliptin. The concern of an increased risk of heart failure remains to be better investigated. [less ▲]

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See detailNumerical study of intrinsic features of isolas in a 2-dof nonlinear system
Detroux, Thibaut ULg; Noël, Jean-Philippe ULg; Masset, Luc ULg et al

in Proceedings of the ICEDyn conference (2015, June)

In the present paper, isolated response curves in a nonlinear system consisting of two masses sliding on a horizontal guide are examined. Transverse springs are attached to one mass to provide the ... [more ▼]

In the present paper, isolated response curves in a nonlinear system consisting of two masses sliding on a horizontal guide are examined. Transverse springs are attached to one mass to provide the nonlinear restoring force, and a harmonic motion of the complete system is imposed by prescribing the displacement of their supports. Numerical simulations are carried out to study the conditions of existence of isolated solutions, their bifurcations, their merging with the main response branch and their basins of attraction. This is achieved using tools including nonlinear normal modes, energy balance, harmonic balance-based continuation and bifurcation tracking, and global analysis. [less ▲]

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See detailDefensins: « simple » antimicrobial peptides or broad-spectrum molecules ?
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Cytokine & Growth Factor Reviews (2015), 26

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See detailChangement climatique et familles politiques en Europe. Entre soutien et résistance aux politiques climatiques
Moelher, Karin; Piet, Grégory ULg; Zaccai, Edwin

in Courrier Hebdomadaire du CRISP (2015), 2257

Le changement climatique constitue une thématique politique relativement récente dans les agendas politiques et électoraux. Souvent, dans le grand public, la question climatique est perçue à travers la ... [more ▼]

Le changement climatique constitue une thématique politique relativement récente dans les agendas politiques et électoraux. Souvent, dans le grand public, la question climatique est perçue à travers la médiatisation des grands sommets des Nations Unies consacrés à cette problématique (Rio de Janeiro en 1992, Kyoto en 1997, Copenhague en 2009, Paris en 2015, etc.). Mais les positions que défendent les différents pays lors de ces réunions ont bien entendu été préalablement construites, entre autres, sur les scènes nationales. Les partis politiques sont à la fois les reflets des opinions publiques et les initiateurs des régulières redéfinitions des orientations politiques qui entourent la thématique du changement climatique. Ils filtrent également les demandes politiques de la société civile qui paraissent compatibles avec leur programme et leur faisabilité, et les transforment. Aux États-Unis, la polarisation politique autour de la question du changement climatique est aisément détectable . Le Republican Party se montre fortement critique, non seulement à l’égard des politiques climatiques discutées dans les cénacles de l’ONU, mais aussi, pour une part de ce courant, quant à l’existence du phénomène du changement climatique d’origine humaine. Ce type de position est particulièrement présent au sein du Tea Party. À l’inverse, le Democratic Party se montre nettement plus favorable à des objectifs climatiques, de même que, à l’instar du président Barack Obama ou du vice-président Al Gore précédemment, il reconnaît sans ambiguïté la réalité de ce phénomène physique, l’estime inquiétant et devant motiver l’action. Qu’en est-il en Europe ? L’opinion publique s’y déclare majoritairement convaincue de la réalité de changements climatiques d’origine anthropique et la trouve préoccupante, même s’il existe une part significative de la population qui en doute. Ce scepticisme se traduit-il toutefois dans les programmes électoraux de certains partis politiques, à l’instar de ce que l’on constate aux États-Unis ? Telle a été la question à la base du présent Courrier hebdomadaire. Annonçons cependant d’emblée que ce que nous désignerons ici par « climato-scepticisme », au sens strict de mise en doute du changement climatique d’origine humaine, n’est qu’un aspect assez partiel de cette étude. Nos résultats révèlent en effet que cette position climato-sceptique est extrêmement minoritaire parmi les formations politiques d’Europe. [less ▲]

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See detailAvis 2/13 de la CJUE : l'obsession du contrôle ?
Petit, Nicolas ULg; Pilorge, Joëlle ULg

in Revue des Affaires Européennes [= RAE] = Law & European Affairs (2015)

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See detailControlled clinical trial of repeated left prefrontal transcranial direct current stimulation in patients with chronic minimally conscious state
Martial, Charlotte ULg; Thibaut, Aurore ULg; Wannez, Sarah ULg et al

Poster (2015, June)

A recent study showed that single-session anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (LDLPF) transiently improves consciousness in 43% of ... [more ▼]

A recent study showed that single-session anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (LDLPF) transiently improves consciousness in 43% of patients in minimally conscious state (MCS) (Thibaut et al., 2014). We here test the potential effects and safety of repeated tDCS in severely brain-damaged patients with MCS. In this double-blind cross-over sham-controlled experimental design, we delivered two sessions of repeated (5 days of stimulation) tDCS, either anodal or sham in a randomized order. We stimulated the LDLPF cortex during twenty minutes in 20 MCS patients (12 men, aged 48±16 years, time since onset 78±95 months, 12 post-traumatic). Consciousness was assessed by the French adaptation of the Coma Recovery Scale Revised (CRS-R; Schnakers et al., 2008) before and after each stimulation. A treatment effect was observed for the comparison between CRS-R total scores at baseline and after 5 days of real tDCS (p<0.01). Behaviorally, 10/20 patients showed a tDCS-related improvement; 5 patients responded after the first stimulation and 5 other patients responded after 2, 3 or 4 days of stimulation. No side effect (e.g. epilepsy) was reported. Our results demonstrate that repeated (5 days) anodal LDLPF tDCS is safe and might improve signs of consciousness in about half of patients in MCS. It is important to note that the first session is not predictive for a future positive effect of the efficacy of the non-invasive electrical stimulation. [less ▲]

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See detailMen in childcare services: From enrolment in training programs to job retention
Pirard, Florence ULg; Schoenmaeckers, Pauline ULg; Camus, Pascale

in European Early Childhood Education Research Journal (2015)

This article presents a study conducted in Federation Wallonia-Brussels (FWB) to identify factors that motivate men to enrol in training programmes and work in a field where women are the majority, in a ... [more ▼]

This article presents a study conducted in Federation Wallonia-Brussels (FWB) to identify factors that motivate men to enrol in training programmes and work in a field where women are the majority, in a context in which few proactive measures are taken to overcome gender stereotypes. Comprehensive interviews conducted with male childcare ‘informants’ who had been working with children under the age of three for at least a year in subsidised childcare centres helped us to identify factors which seemed to influence their decision to enrol in and continue an initial training programme with a curriculum that is not genderneutral, and then work in a profession that is almost exclusively female. [less ▲]

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See detailHydrodynamics, mixing and mass transfer in baffled stirred tanks
de Lamotte, Anne ULg; Delafosse, Angélique ULg; Calvo, Sébastien ULg et al

Conference (2015, June)

The present work presents CFD simulations of hydrodynamics, mixing and mass transfer in a surface-aerated baffled stirred tank. The modelling of the multiphase flow is realized via an Euler-Euler approach ... [more ▼]

The present work presents CFD simulations of hydrodynamics, mixing and mass transfer in a surface-aerated baffled stirred tank. The modelling of the multiphase flow is realized via an Euler-Euler approach. Three closure models are tested for the resolution of the RANS equations. When fully-developed flow field is reached, gas-liquid transfer is implemented with a local mass transfer coefficient estimated by the eddy cell model, and the temporal evolution of dissolved gas concentration is predicted.Hydrodynamic and mixing quantities as well as mass transfer parameters for the different turbulence models are compared with experimental data available for the same geometrical and operating features. A critical analysis of the prediction results allow to assess the models capabilities and to highlight the possible critical issues of the simulations. [less ▲]

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See detailA process to address electricity distribution sector challenges: the GREDOR project approach
Cornélusse, Bertrand ULg; Vangulick, David; Glavic, Mevludin ULg et al

in Proceedings of the International Conference on Electricity Distribution, CIRED 2015 (2015, June)

This paper presents a general process set in the GREDOR (French acronym for “Gestion des Réseaux Electriques de Distribution Ouverts aux Renouvelables”) project to address the challenges in distribution ... [more ▼]

This paper presents a general process set in the GREDOR (French acronym for “Gestion des Réseaux Electriques de Distribution Ouverts aux Renouvelables”) project to address the challenges in distribution systems posed by the integration of renewable generation, changing load patterns, and the changes in the electricity market sector. A use case describing interactions among different players that fits the process is also presented. A pseudo-dynamic approach to Global Capacity Announcement as a way to increase penetration of Renewable Energy Sources in a distribution system is elaborated in more details. [less ▲]

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See detailGraph matching for reconciling SCADA and GIS of a distribution network
Cornélusse, Bertrand ULg; Leroux, Amandine; Glavic, Mevludin ULg et al

in Proceedings of the International Conference on Electricity Distribution, CIRED 2015 (2015, June)

This article deals with the problem of automatically es- tablishing a correspondence between two databases popu- lated independently over the years by a distribution com- pany, for instance a SCADA system ... [more ▼]

This article deals with the problem of automatically es- tablishing a correspondence between two databases popu- lated independently over the years by a distribution com- pany, for instance a SCADA system and a geographical information system. This problem is abstracted as a graph matching problem, well known in the combinatorial op- timisation community. It is then casted as an integer quadratic program. An idea of achievable results on a real system is provided, and needs for approximation or decom- position algorithms are discussed. [less ▲]

Detailed reference viewed: 179 (8 ULg)