Last 7 days
Bookmark and Share    
Full Text
See detailEVALUATION OF CONTINUOUS SUPRASCAPULAR NERVE BLOCKADE IN THE TREATMENT OF REFRACTORY ADHESIVE CAPSULITIS : A RETROSPECTIVE STUDY
MUTSERS, Pierre ULg; LECOQ, Jean-Pierre ULg; GOFFIN, Pierre ULg et al

in Abstract Book du Residence Meeting de la Société Belge d'Anesthésie (2015, June 15)

Detailed reference viewed: 20 (4 ULg)
Full Text
See detailL'activité de la NADPH oxydase : une nouvelle cible pour la curcumine ?
Derochette, Sandrine ULg

Doctoral thesis (2015)

La NADPH oxydase (Nox2) des neutrophiles (PMNs) est une enzyme multi-protéique responsable de la production d'espèce activées de l'oxygène (ROS) pour la destruction des pathogènes. L'activation excessive ... [more ▼]

La NADPH oxydase (Nox2) des neutrophiles (PMNs) est une enzyme multi-protéique responsable de la production d'espèce activées de l'oxygène (ROS) pour la destruction des pathogènes. L'activation excessive des PMNs est souvent associée à des pathologies mortelles chez le cheval, faisant de l'activité de la Nox2 une cible thérapeutique privilégiée. Le premier but de ce travail, a été de développer une méthode appelée "cell-free system" (CSF) pour mesurer l'activité in vitro de la Nox2 équine. Un inconvénient de cette technique sont les interférences possibles entre les inhibiteurs et la sonde utilisée pour la mesure de l'activité. Sur base de notre CFS, nous avons créé l'EquiNox2, un nouvel outil pharmacologique, pour étudier les interactions entre des inhibiteurs et la Nox2 et leurs effets sur l'assemblage et l'activité de l'enzyme. Cette méthode consiste en la mesure in vitro de l'activité de la Nox2 fixée sur un support solide, ce qui permet d'éliminer les inhibiteurs avant la mesure de l'activité et réduit les interférences citées pour le CFS. Le CFS et l'EquiNox2 ont été validés avec le diphénylène iodonium et le Gp91ds-tat, deux inhibiteurs connus de la Nox2 humaine. Le deuxième but de ce travail, était l'étude du NDS27, un complexe de lysinate de curcumine avec l'hydroxypropyl-β-cyclodextrine (HPβCD) sur la réponse oxydante des PMNs. Le NDS27, n'est pas toxique et est capable d'entrer et d'interagir avec les membranes des PMNs et d'inhiber l'activité de la myéloperoxydase, la Nox2 et la PKCδ (un activateur de Nox2) impliquées dans la production de ROS. Nous avons montré en CFS et EquiNox2 que le NDS27 se fixe fortement à la Nox2 pour empêcher son assemblage et que l'HPβCD, l'excipient du NDS27, en plus de solubiliser et transporter la curcumine, augmente l'action de celle-ci sur les activités de la PKC et la Nox2. L'effet modulateur du NDS27 sur l'activation de la Nox2 ouvre des perspectives thérapeutiques pour traitement des pathologies accompagnées de réactions inflammatoires excessives. [less ▲]

Detailed reference viewed: 31 (6 ULg)
See detailLes biotechnologies de la reproduction des petits camélidés sud-américains
Hanzen, Christian ULg; Cucho Dolmo, Hernan; Ampuero Casquino, Enrique et al

E-print/Working paper (2015)

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailIs it possible for large herds to graze while keeping a high milk yield level? The experience of two Belgian dairy farms.
Lessire, Françoise ULg; Hornick, Jean-Luc ULg; Dufrasne, Isabelle ULg

in van den Pol-van Dasselaer, Agnes; Aarts, H.F.M; De Vliegher, Alex (Eds.) et al Grassland and forages in high output dairy farming systems (2015, June 15)

Grazing is more and more abandoned because of increasing size of herds and automation of herd management (e.g. automatic milking system – AMS). In this context, this study aims to evaluate milk production ... [more ▼]

Grazing is more and more abandoned because of increasing size of herds and automation of herd management (e.g. automatic milking system – AMS). In this context, this study aims to evaluate milk production and composition of 2 large Belgian dairy herds equipped with AMS during winter and summer. These herds were followed over 2 years. At grazing, 30% of the offered feed was grass. Milk production in both herds was similar in summer and winter (30.2 ± 7.14 vs 29.7 ± 7.8 ± in Herd 1 and 26.9 ± 0.8 vs 26.4 ± 0.8 in Herd 2) while their milk composition differed. In conclusion, it is possible for grazing to be preserved even in large herds without impacting noticeably on the herd performance. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
See detailLa projection turque dans les Balkans occidentaux: défi ou opportunité pour l'Union européenne?
Lika, Liridon ULg

Scientific conference (2015, June 15)

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailCommercial farming of Leiolepis guttata in Binh Thuan province, Vietnam: implications for conservation and management
Rochette, Anne-Julie; Tran, Tinh ULg; De Martynoff, Abigail et al

in Herpetological Conservation and Biology (2015), 10(1),

Since the first Indochinese war, natural populations of Leiolepis guttata have been hunted for their meat in southeastern Vietnam as a subsistence meal; nowadays, it has become a luxury delicacy ... [more ▼]

Since the first Indochinese war, natural populations of Leiolepis guttata have been hunted for their meat in southeastern Vietnam as a subsistence meal; nowadays, it has become a luxury delicacy. Commercial farms have become established since 2004 because of wild population declines and increasing demand for meat. We interviewed farmers and restaurateurs about the breeding and trade of the species to better understand the impact on wild populations. The results highlight the recent flourishing expansion of farming with rapidly increasing product prices and number of farms, as well as the ease and profitability of this activity. Wild population declines are widely acknowledged by authorities and local communities. Farms are being regarded as conservation pools to offset wild stock depletion, in addition to an important source of income. We discuss the risks associated with this trade development and we emphasize the conservation implications. Demand for lizards as founders for farms and for meat are likely to increase further, but risks exist that the development of new farms would saturate the market causing prices to ultimately fall. Habitat destruction and over-collecting severely reduce wild populations, but the high densities of farmed lizards raise serious genetic and sanitary issues. We suggest that further information should be collected to assess the sustainability of this trade. Priority should be given to the assessment of natural population densities and hunting effort. Biological patterns of this species are poorly documented and sound knowledge would enable better management of farms, and if this species is recognized as endangered could lead restrictions on harvesting of wild populations. [less ▲]

Detailed reference viewed: 27 (7 ULg)
See detailEvaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture organisé par le réseau public de la lecture et les bibliothèques publiques. Troisième rapport : deuxième partie : premières pistes de conclusion
Fallon, Catherine ULg; Halin, Jordan ULg; Italiano, Patrick ULg et al

Report (2015)

This report presents conclusions of an external evaluation of reading public service in Wallonia-Brussel Federation. The evaluation is about implementation of the "décret du 30 avril 2009 relatif au ... [more ▼]

This report presents conclusions of an external evaluation of reading public service in Wallonia-Brussel Federation. The evaluation is about implementation of the "décret du 30 avril 2009 relatif au développement des pratiques de lecture organisé par le réseau public de la lecture et les bibliothèques publiques". Several qualitatives methods were used: Delphi online method, case studies and focus groups. [less ▲]

Detailed reference viewed: 25 (1 ULg)
Full Text
Peer Reviewed
See detailLiminarité, métadiscours, et théâtre voltairien
Daubercies, Laurence ULg

in Revue Voltaire (2015, June 12)

Detailed reference viewed: 17 (1 ULg)
See detailEtude de la sémaphorine virale codée par le gène A3 de l’herpèsvirus alcélaphin 1
Myster, Françoise

Doctoral thesis (2015)

Among gammaherpesvirus, the Macavirus genus is composed of viruses associated to malignant catarrhal fever (MCF) and other phylogenetically related viruses. MCF is a frequently fatal lymphoproliferative ... [more ▼]

Among gammaherpesvirus, the Macavirus genus is composed of viruses associated to malignant catarrhal fever (MCF) and other phylogenetically related viruses. MCF is a frequently fatal lymphoproliferative disease. Three macaviruses inducing MCF have been entirely sequenced: alcelaphine herpesvirus 2 (AlHV-2), ovine herpesvirus 2 (OvHV-2) and alcelaphine herpesvirus 1 (AlHV-1). Sheep carries OvHV-2 asymptomatically while wildebeest is infected with AlHV-1 without developing any clinical signs or lesions. Both viruses represent the most studied macaviruses. In susceptible ruminants, OvHV-2 and AlHV-1 induce the sheep-associated form and the wildebeest-derived form of MCF (WD-MCF), respectively. Economic consequences of WD-MCF are significant in sub-Saharan Africa. WD-MCF is characterized by the proliferation and infiltration of lymphoblastoid T cells surrounding blood vessels and can be considered as a model for peripheral T cell lymphoma caused by a virus. Rabbits are used as experimental model to study MCF. This species develops clinical signs and lesions that they are indistinguishable from those observed in other susceptible species. Until recently, available data on WD-MCF pathogenesis were limited to the simple description clinical signs and lesions. Recently, it was demonstrated that CD8+ T cells proliferate and that this cellular expansion is associated with a severe increase of the viral load in PBMC and lymphoid organs (Dewals et al., 2008). The cloning of the AlHV-1 genome as an infectious and pathogenic bacterial artificial chromosome (BAC) has greatly facilitated the study of individual gene of AlHV-1 (Dewals et al., 2006). Among herpesviruses, viral semaphorins can only be found in members of the Macavirus genus. OvHV 2 encodes Ov3, and AlHV-2 and AlHV-1 encode A3, both genes encoding a semaphorin homolog. Semaphorins are proteins characterized by a conserved amino-terminal domain, the SEMA domain. The roles of the semaphorins on cytoskeleton dynamics have been widely studied. Viral semaphorins could mediate immune evasion mechanisms or viral dissemination and could be involved in specific properties of macaviruses. The first study of the present thesis was dedicated to the investigation of the pathogenesis of WD-MCF and the role of latency. We investigated the distribution of the AlHV-1 infection in the lesions and demonstrated that the infiltration of CD8+ T cells in different lymphoid and non-lymphoid organs and tissues is directly associated with a non-productive viral infection. The second study focused on the A3 gene of AlHV-1 and its potential functions during WD-MCF. We showed that the A3 gene is expressed during the early phase of the viral infection and encodes a functional semaphorin that was termed AlHV-sema. AlHV-sema was able to induce cell retraction. Despite the observed independent acquisition of pox- and herpesvirus semaphorins, AlHV-sema inhibited phagocytosis by dendritic cells and migration to the draining lymph node through mechanisms similar to poxvirus semaphorin. AlHV-sema could also facilitate viral dissemination or confer immune evasion functions. Next, we investigated whether AlHV-sema could affect WD-MCF induction. We did not observe any effect of the absence of AlHV-sema expression during the development of WD-MCF after rabbit nasal infection. Macaviruses are swine and ruminant gammaherpesviruses responsible for a latent asymptomatic infection in their natural species. The development of MCF in other ruminant susceptible species is due to cross-species transmission. During evolution, the gene selection in susceptible species is certainly reduced due to the fact that these species are dead-end hosts. Thus, it is difficult to address the role of AlHV-1 specific genes in MCF as these genes have evolved in other species. Nevertheless, we brought in this work important insight for our understanding of the pathogenesis of WD-MCF and we identified AlHV-sema as a potential immunoevasion factor. DEWALS B., MYSTER F., PALMEIRA L., GILLET L., ACKERMANN M., VANDERPLASSCHEN A. Ex vivo bioluminescence detection of alcelaphine herpesvirus 1 infection during malignant catarrhal fever. J. Virol., 2011, 85, 6941-6954. MYSTER F., PALMEIRA L., SOREL O., BOUILLENNE F., DEPAUW E., SCHWARTZ-CORNIL I., VANDERPLASSCHEN A., DEWALS B.G. Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gamma-herpesvirus-induced lymphoproliferation in malignant catarrhal fever. J. Virol., 2015. [less ▲]

Detailed reference viewed: 16 (4 ULg)
See detailPaul Philippot et la fortune de la Teoria de Cesare Brandi
Verbeeck, Muriel ULg

Conference (2015, June 12)

Même si le propos peut sembler iconoclaste, Cesare Brandi est un auteur plus souvent cité que lu, du moins, en dehors de l'Italie. On note en effet un hiatus important entre la première publication de la ... [more ▼]

Même si le propos peut sembler iconoclaste, Cesare Brandi est un auteur plus souvent cité que lu, du moins, en dehors de l'Italie. On note en effet un hiatus important entre la première publication de la Teoria, en 1963, et les rééditions et traductions qui vont permettre de diffuser le texte original. Pendant près de trente ans, la dissémination de la pensée de Brandi sur le plan international sera le fait de Paul Philippot. Il fut plus qu'un traducteur, un génial interprète de la pensée brandienne au sein des Institutions et et son promoteur au sein des formations de restaurateurs. Sa place demeure essentielle dans l'actualisation de la Teoria. [less ▲]

Detailed reference viewed: 22 (0 ULg)
Full Text
See detailAn economic case for transnational and international transmission
Ernst, Damien ULg

Speech/Talk (2015)

Detailed reference viewed: 57 (8 ULg)
Full Text
See detailRecent ethane increase above North America: comparison between FTIR measurements and model simulations
Franco, Bruno ULg; Bader, Whitney ULg; Mahieu, Emmanuel ULg et al

Conference (2015, June 11)

Ethane (C2H6) has a large impact on tropospheric composition and air quality because of its involvement in the global VOC (volatile organic compound) – HOx – NOx chemistry responsible for generating and ... [more ▼]

Ethane (C2H6) has a large impact on tropospheric composition and air quality because of its involvement in the global VOC (volatile organic compound) – HOx – NOx chemistry responsible for generating and destroying tropospheric ozone. By acting as a major sink for tropospheric OH radicals, the abundance of C2H6 influences the atmospheric content of carbon monoxide and impacts the lifetime of methane. Moreover, it is an important source of PAN, a thermally unstable reservoir for NOx radicals. On a global scale, the main sources of C2H6 are leakage from the production, transport of natural gas loss, biofuel consumption and biomass burning, mainly located in the Northern Hemisphere. Due to its relatively long lifetime of approximately two months, C2H6 is a sensitive indicator of tropospheric pollution and transport. Using an optimized retrieval strategy (see Franco et al., 2014), we present here a 20-year long-term time series of C2H6 column abundance retrieved from ground-based Fourier Transform InfraRed (FTIR) solar spectra recorded from 1994 onwards at the high-altitude station of Jungfraujoch (Swiss Alps, 46.5° N, 3580 m a.s.l.), part of the Network for the Detection of Atmospheric Composition Change (NDACC, see http://www.ndacc.org). After a regular 1994 – 2008 decrease of the C2H6 amounts, which is very consistent with prior major studies (e.g., Aydin et al., 2011; Simpson et al., 2012) and our understanding of global C2H6 emissions, trend analysis using a bootstrap resampling tool reveals a C2H6 upturn and a statistically-significant sharp burden increase from 2009 onwards (Franco et al., 2014). We hypothesize that this observed recent increase in C2H6 could affect the whole Northern Hemisphere and may be related to the recent massive growth in the exploitation of shale gas and tight oil reservoirs. This hypothesis is supported by measurements derived from solar occultation observations performed since 2004 by the Atmospheric Chemistry Experiment – Fourier Transform Spectrometer (ACE-FTS) instrument and at other NDACC sites, namely Toronto (44° N) and Thule (77° N). Indeed, the recent rates of changes characterizing these data sets are consistent in magnitude and sign with the one derived from the FTIR measurements at Jungfraujoch. In contrast, the ethane time series form Lauder (45° S) shows a monotonic decrease over the last two decades. Investigating both the cause and impact on air quality of the C2H6 upturn should be a high priority for the atmospheric chemistry community. [less ▲]

Detailed reference viewed: 41 (3 ULg)
Full Text
Peer Reviewed
See detailAPOBEC3 Interference during Replication of Viral Genomes
Willems, Luc ULg; Gillet, Nicolas ULg

in Viruses (2015)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailA semiquantitative framework for gene regulatory networks: increasing the time and quantitative resolution of Boolean networks
Kerkhofs, Johan ULg; Geris, Liesbet ULg

in PLoS ONE (2015), 10(6), 0130033

Boolean models have been instrumental in predicting general features of gene networks and more recently also as explorative tools in specific biological applications. In this study we introduce a basic ... [more ▼]

Boolean models have been instrumental in predicting general features of gene networks and more recently also as explorative tools in specific biological applications. In this study we introduce a basic quantitative and a limited time resolution to a discrete (Boolean) framework. Quantitative resolution is improved through the employ of normalized variables in unison with an additive approach. Increased time resolution stems from the introduction of two distinct priority classes. Through the implementation of a previously published chondrocyte network and T helper cell network, we show that this addition of quantitative and time resolution broadens the scope of biological behaviour that can be captured by the models. Specifically, the quantitative resolution readily allows models to discern qualitative differences in dosage response to growth factors. The limited time resolution, in turn, can influence the reachability of attractors, delineating the likely long term system behaviour. Importantly, the information required for implementation of these features, such as the nature of an interaction, is typically obtainable from the literature. Nonetheless, a trade-off is always present between additional computational cost of this approach and the likelihood of extending the model’s scope. Indeed, in some cases the inclusion of these features does not yield additional insight. This framework, incorporating increased and readily available time and semi-quantitative resolution, can help in substantiating the litmus test of dynamics for gene networks, firstly by excluding unlikely dynamics and secondly by refining falsifiable predictions on qualitative behaviour. [less ▲]

Detailed reference viewed: 28 (2 ULg)
Full Text
Peer Reviewed
See detailImpact of Different Thermal Comfort Models on Zero Energy Residential Buildings in Hot Climate
Attia, Shady ULg; Carlucci, Salvatore

in Energy & Buildings (2015)

The selection of a thermal comfort model for establishing indoor optimal hygrothermal conditions during the hot period has a major impact on energy consumption of Net Zero Energy Buildings in hot climates ... [more ▼]

The selection of a thermal comfort model for establishing indoor optimal hygrothermal conditions during the hot period has a major impact on energy consumption of Net Zero Energy Buildings in hot climates. The objective of this paper is to compare the influence of using different thermal comfort models for zero energy buildings in hot climates. The paper compares the impact of applying Fanger’s model, Givoni’s model, the ASHRAE 55 adaptive comfort model and the EN 15251 adaptive comfort model on energy consumption and comfort performance. Using both the building performance simulation tools ZEBO and EnergyPlus for energy simulation, an existing prototype of a residential apartment module is used to evaluate energy performance and thermal comfort in two parametric series. The first one is the result of coupling natural ventilation and mechanical cooling and the second one is guided coupling natural ventilation, mechanical cooling and ceiling fans. This study shows that the percentage of energy consumption difference meeting the comfort criteria according to ISO 7730 in comparison to EN 15251, ASHRAE 55 or Givoni’s model varied up to 16%, 21% and 24.7% respectively for the presented case study. More energy savings can be expected for buildings in hot climates with greater cooling demands. [less ▲]

Detailed reference viewed: 50 (5 ULg)