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See detailβ 5 tubulin and 15-protofilament microtubules appeared in supporting cells of the Corti’s organ during development in rodents
Renauld, Justine ULg; Thelen, Nicolas ULg; Johnen, Nicolas et al

Conference (2014, August 31)

A feature of the organ of Corti’s supporting cells is the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor ... [more ▼]

A feature of the organ of Corti’s supporting cells is the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor mammalian tubulin, the β5-tubulin [1], recently related as a biomarker for cancer outcome [2] and cell proliferation [3]. It was shown that a β-tubulin isoform can specified the microtubule architecture, such as the expression of the Moth β2 in the Drosophila testes imposed the 16 protofilaments (16pf) structure on the corresponding subset of Drosophila microtubules, which normally contain 13pf [4]. Moreover, supporting cell microtubules are formed by 15pf instead of the canonical 13, a unique fact among vertebrates [5]. Such a protofilament configuration has been observed in C. elegans’ neurons which are responsible for the mechanosensory sense of touch [6]. It was also shown that these 15pf microtubules were essential to the proper functioning of these mechanosensory neurons [6]. To determine the role of this particular tubulin in the auditory organ and its possible involvement in the formation of the unusual 15pf microtubules of supporting cells, we studied the spatiotemporal localization of β5-tubulin during development in rats from embryonic day 18 until P25 (25th postnatal day). We also analyzed the localization of β5-tubulin mRNA expression in the Corti’s organ. Then we examined the fine structure of microtubules at the electron microscope level. For these experiments, we used an early postnatal stage and a late postnatal stage. Our results showed that β5-tubulin, contrary to other β-tubulins, had a unique distribution in the cochlea. This β-tubulin appeared at a postnatal stage, before the opening of the Corti’s tunnel and being restricted to supporting cells, especially in pillar and Deiters cells,. The same localization of β5-tubulin mRNA was observed by in Situ Hybridization. Electron microscopy indicated further that Pillar and Deiters cells were composed by 15-protofilament microtubules at the late postnatal stage (P25). In conclusion, all these data strongly suggest that there is a relationship between the presence of β5-tubulin and 15-protofilament microtubules in the supporting cells of the auditory organ. Further studies are now needed to elucidate their role. [less ▲]

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See detailAmélioration des moyens d'existence durables. Une voie pour la durabilité des exploitations agricoles familiales de coton au Bénin
Assogba, Claude Gervais; Tossou, C. R.; Lebailly, Philippe ULg et al

Conference (2014, August 30)

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See detailThe effects of a Global Agricultural Policy on the smallholder farmers in ending hunger
Paveliuc-Olariu, Codrin; Burny, Philippe ULg

Conference (2014, August 30)

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See detailL'agriculture de subsistance et de semi-subsistance en Roumanie
Dona, Ion; Burny, Philippe ULg

Conference (2014, August 30)

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See detailAspects économiques de la filière du vermicelle de tolomane au Vietnam
Le Thi Long, Vy; Vu Dinh, Ton; Lebailly, Philippe ULg et al

Conference (2014, August 30)

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See detailProblématique foncière chez les exploitants agricoles de la Province de Kirundo au nord du Burundi
Minani, Bonaventure; Rurema, Déo-Guide; Burny, Philippe ULg et al

Conference (2014, August 30)

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See detailAccelerating Random Forests in Scikit-Learn
Louppe, Gilles ULg

Conference (2014, August 29)

Random Forests are without contest one of the most robust, accurate and versatile tools for solving machine learning tasks. Implementing this algorithm properly and efficiently remains however a ... [more ▼]

Random Forests are without contest one of the most robust, accurate and versatile tools for solving machine learning tasks. Implementing this algorithm properly and efficiently remains however a challenging task involving issues that are easily overlooked if not considered with care. In this talk, we present the Random Forests implementation developed within the Scikit-Learn machine learning library. In particular, we describe the iterative team efforts that led us to gradually improve our codebase and eventually make Scikit-Learn's Random Forests one of the most efficient implementations in the scientific ecosystem, across all libraries and programming languages. Algorithmic and technical optimizations that have made this possible include: - An efficient formulation of the decision tree algorithm, tailored for Random Forests; - Cythonization of the tree induction algorithm; - CPU cache optimizations, through low-level organization of data into contiguous memory blocks; - Efficient multi-threading through GIL-free routines; - A dedicated sorting procedure, taking into account the properties of data; - Shared pre-computations whenever critical. Overall, we believe that lessons learned from this case study extend to a broad range of scientific applications and may be of interest to anybody doing data analysis in Python. [less ▲]

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See detailComputational homogenization of cellular materials with propagation of instabilities through the scales
Nguyen, Van Dung ULg; Noels, Ludovic ULg

Conference (2014, August 29)

The aim of this work is to develop an efficient multi–scale finite element framework to capture the buckling instabilities in cellular materials. As a classical multi–scale computational homogenization ... [more ▼]

The aim of this work is to develop an efficient multi–scale finite element framework to capture the buckling instabilities in cellular materials. As a classical multi–scale computational homogenization scheme looses accuracy with the apparition of the macroscopic localizations resulting from the micro–buckling, the second–order multi–scale computational homogenization scheme1 is considered. This second–order computational framework is herein enhanced with the following novelties so that it can be used for cellular materials. First, at the microscopic scale, the periodic boundary condition is used because of its efficiency. As the meshes generated from cellular materials exhibit a large void part on the boundaries and are not conforming in general, the classical enforcement based on the matching nodes cannot be applied. A new method based on the polynomial interpolation2 without the requirement of the matching mesh condition on opposite boundaries of the representative volume element (RVE) is developed. Next, in order to solve the underlying macroscopic Mindlin strain gradient continuum of this second–order scheme by the displacement–based finite element framework, the treatment of high order terms is based on the discontinuous Galerkin (DG) method to weakly impose the C1-continuity3. Finally, as the instability phenomena are considered at both scales of the cellular materials, the path following technique is adopted to solve both the macroscopic and microscopic problems4. The micro–buckling leading to the macroscopic localization and the size effect phenomena can be captured within the proposed framework. In particular it is shown that results are not dependent on the mesh size at the macroscopic scale during the softening response, and that they agree well with the direct numerical simulations. [less ▲]

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See detailLower critical field and SNS-Andreev spectroscopy of 122-arsenides: Evidence of nodeless superconducting gap
Abdel-Hafiez, M.; Pereira, P.J.; Kuzmichev, S.A. et al

in Physical Review. B : Condensed Matter (2014), 90

Using two experimental techniques, we studied single crystals of the 122-FeAs family with almost the same critical temperature, Tc. We investigated the temperature dependence of the lower critical field ... [more ▼]

Using two experimental techniques, we studied single crystals of the 122-FeAs family with almost the same critical temperature, Tc. We investigated the temperature dependence of the lower critical field Hc1(T) of a Ca0.32Na0.68Fe2As2 (Tc ≈ 34 K) single crystal under static magnetic fields H parallel to the c axis. The temperature dependence of the London penetration depth can be described equally well either by a single anisotropic s-wave-like gap or by a two-gap model, while a d-wave approach cannot be used to fit the London penetration depth data. Intrinsic multiple Andreev reflection effect spectroscopy was used to detect bulk gap values in single crystals of the intimate compound Ba0.65K0.35Fe2As2, with the same Tc. We estimated the range of the large gap value L = 6–8 meV (depending on small variation of Tc) and its a k space anisotropy of about 30%, and the small gap Delta ≈ 1.7 ± 0.3 meV. This clearly indicates that the gap structure of our investigated systems more likely corresponds to a nodeless s-wave two gaps. [less ▲]

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See detailResponsabilité sociale et entreprises à risque
Robert, Jocelyne ULg; Frau, Maité; al

Conference (2014, August 29)

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See detailA post-mortem study of physiopathological characteristics of genital tracts of culled dairy cows in South Vietnam.
Nguyen Kien, Cuong; Okouyi, Marcel; Hanzen, Christian ULg

Poster (2014, August 28)

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See detailL'odeur : question de sens ou de chimie
Romain, Anne-Claude ULg

Scientific conference (2014, August 28)

Afin de mesurer au mieux un paramètre, il faut préalablement connaître son identité. Concernant la métrologie de la pollution olfactive, toute la difficulté réside dans la particularité de cette pollution ... [more ▼]

Afin de mesurer au mieux un paramètre, il faut préalablement connaître son identité. Concernant la métrologie de la pollution olfactive, toute la difficulté réside dans la particularité de cette pollution. En effet, bien qu’associée à la pollution de l’air par les molécules volatiles qui la génèrent, elle en diffère par son effet sensoriel. Il va de soi que la pollution olfactive n’a de sens que par son odeur. Chaque individu a son propre odorat et dès lors sa propre interprétation de l’odeur. C’est cette subjectivité qui rend cette pollution si délicate à qualifier et à quantifier et qui la distingue de la pollution de l’air. De plus, contrairement à d’autres pollutions sensorielles de type sonore ou visuel, l’élément porteur ’est pas dans ce cas une grandeur physique telle que la longueur d’onde électromagnétique ou la variation de pression mais une grandeur physico-chimique particulière dont la mesure est beaucoup plus complexe. Un dictionnaire de langue française définit l’odeur comme « une émanation volatile, caractéristique de certains corps et susceptible de provoquer chez l’homme ou chez un animal des sensations dues à l’excitation d’organes spécialisés ». Cette définition de l’odeur met notamment en jeu deux disciplines : la chimie et la physiologie. En effet un chimiste pourrait présenter l’odeur comme un ensemble de molécules aux propriétés spécifiques qui inhalées par un individu génère une réaction, il s’intéresserait dès lors aux odorants alors qu’un physiologiste parlerait plutôt du stimulus induit par ces odorants et des mécanismes qui le provoquent au niveau des organes. Le traitement de l’information olfactive par le cerveau, la perception olfactive, conduit à plusieurs types de sensation. En effet, l’odeur perçue a trois grandes particularités : l’intensité, la qualité (ou la nature de l’odeur) et la tonalité hédonique ou affective (agrément/désagrément). A ces trois dimensions, il faut ajouter le caractère temporel du stimulus, dimension très utilisée dans le cadre de la pollution olfactive. [less ▲]

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See detailBayesian approach integrating correlated foreign information into a multivariate genetic evaluation
Vandenplas, Jérémie ULg; Gengler, Nicolas ULg

in Book of Abstracts of the 65th Annual Meeting of the European Federation of Animal Science (2014, August 28)

High-perfomance computing facilities proposing shared-memory and distributed-memory multiprocessors are becoming available. With those clusters, parallel computing could lead to increased performances and ... [more ▼]

High-perfomance computing facilities proposing shared-memory and distributed-memory multiprocessors are becoming available. With those clusters, parallel computing could lead to increased performances and problem sizes. However, to our knowledge and especially for variance components estimations, most software available in animal breeding, based on sparse matrices computations, do not allow parallel computing and are limited by memory accessible by the central processing unit, or allow parallel computing only for options with dense matrices computations, which limits anyway problem sizes due to storage of dense matrices. The aim was to propose simple and effective modifications for the BLUPF90 family of programs to reduce computing time with consideration of required memory. Modifications were based on academic free packages proposing solver and sparse inversion for sparse symmetric indefinite linear systems. First, modifications concerned the sparse inversion subroutine implemented in the package FSPAK. Rearrangements of 'do' loops to allow optimizations of computer operations by some compilers and addition of OpenMP directives were performed. The ordering operation was modified to more easily compare a multiple minimum degree algorithm (MMD; implemented in FSPAK) and a multilevel nested dissection algorithm (implemented in METIS 4.0.3). Second, the package PARDISO Version 5.0.0 was used instead of FSPAK. This package proposes in particular a parallel solver and sparse inversion on shared-memory multiprocessors. Modified FSPAK and PARDISO were compared to original FSPAK using MMD through REMLF90. Different models, such as univariate or bivariate (random regressions) test-day animal and single-step genomic models, were tested. All jobs were run 5 times. With an appropriate ordering algorithm, speedup for each REMLF90 iteration were up to 7.5 for modified FSPAK and up to 22.8 for PARDISO with 2 threads. With 4 threads, speedup increased to 8.3 and 32.5, respectively. [less ▲]

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See detailUse of high performance computing in animal breeding
Vandenplas, Jérémie ULg; Gengler, Nicolas ULg

Poster (2014, August 28)

High-perfomance computing facilities proposing shared-memory and distributed-memory multiprocessors are becoming available. With those clusters, parallel computing could lead to increased performances and ... [more ▼]

High-perfomance computing facilities proposing shared-memory and distributed-memory multiprocessors are becoming available. With those clusters, parallel computing could lead to increased performances and problem sizes. However, to our knowledge and especially for variance components estimations, most software available in animal breeding, based on sparse matrices computations, do not allow parallel computing and are limited by memory accessible by the central processing unit, or allow parallel computing only for options with dense matrices computations, which limits anyway problem sizes due to storage of dense matrices. The aim was to propose simple and effective modifications for the BLUPF90 family of programs to reduce computing time with consideration of required memory. Modifications were based on academic free packages proposing solver and sparse inversion for sparse symmetric indefinite linear systems. First, modifications concerned the sparse inversion subroutine implemented in the package FSPAK. Rearrangements of 'do' loops to allow optimizations of computer operations by some compilers and addition of OpenMP directives were performed. The ordering operation was modified to more easily compare a multiple minimum degree algorithm (MMD; implemented in FSPAK) and a multilevel nested dissection algorithm (implemented in METIS 4.0.3). Second, the package PARDISO Version 5.0.0 was used instead of FSPAK. This package proposes in particular a parallel solver and sparse inversion on shared-memory multiprocessors. Modified FSPAK and PARDISO were compared to original FSPAK using MMD through REMLF90. Different models, such as univariate or bivariate (random regressions) test-day animal and single-step genomic models, were tested. All jobs were run 5 times. With an appropriate ordering algorithm, speedup for each REMLF90 iteration were up to 7.5 for modified FSPAK and up to 22.8 for PARDISO with 2 threads. With 4 threads, speedup increased to 8.3 and 32.5, respectively. [less ▲]

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See detailInnovative lactation stage specific prediction of CH4 from milk MIR spectra
Vanlierde, Amélie; Vanrobays, Marie-Laure ULg; Dehareng, Frédéric et al

Conference (2014, August 28)

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See detailInteractions in massive binaries: spectral modelling – CoMBiSpeC – and observational analyses
Palate, Matthieu ULg

Doctoral thesis (2014)

Massive stars are very important to the life of the galaxiesbut they are rare and many open questions on their formation, evolution and characteristics remain. One of the best ways to improve our ... [more ▼]

Massive stars are very important to the life of the galaxiesbut they are rare and many open questions on their formation, evolution and characteristics remain. One of the best ways to improve our knowledge on massive stars is to study massive binaries (that represent at least 50% of massive stars see Mahy et al. 2009, and Sana & Evans 2011) and their spectra. Spectral and atmosphere modelling of stars are very interesting tools that are now often used in spectral analyses. However, these models are designed for single spherical stars. In this context, we have developed a numerical code of spectral modelling of massive binary systems: CoMBiSpeC (code of massive binary spectral computation) that computes the spectra of massive binary systems and accounts for various effects that affect these systems. Our models, and the observational analyses of the four binary systems presented in the second part of this work, have allowed to explain several effects linked to binarity: luminosity class discrepancy, temperature distribution, Struve-Sahade effect, and some kind of line profile variations. In summary, CoMBiSpeC is a first step in the spectral modelling of massive binary systems and several improvements are still needed to be able to study all massive binaries. Nevertheless, this model can explain and reproduce various observed phenomena which was the main goal of this thesis. [less ▲]

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See detailIntroduction à la Théorie générale de l'Etat - Manuel (3e édition)
Behrendt, Christian ULg; Bouhon, Frédéric ULg

Book published by Larcier (2014)

Detailed reference viewed: 109 (34 ULg)