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See detailThoracic endovascular aortic repair (TEVAR) in proximal (type A) aortic dissection: Ready for a broader application?
Nienaber, Christoph A.; Sakalihasan, Natzi ULg; Clough, Rachel E. et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2017)

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role ... [more ▼]

OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) has demonstrated encouraging results and is gaining increasing acceptance as a treatment option for aortic aneurysms and dissections. Yet, its role in managing proximal aortic pathologies is unknown-this is important because in proximal (Stanford type A) aortic dissections, 10% to 30% are not accepted for surgery and 30% to 50% are technically amenable for TEVAR. We describe our case series of type A aortic dissections treated by using TEVAR. METHODS: Between year 2009 and 2016, 12 patients with acute, subacute, or chronic type A aortic dissection with the proximal entry tear located between the coronaries and brachiocephalic artery were treated with TEVAR at 3 centers. Various stent-graft configurations were used to seal the proximal entry tear in the ascending aorta under rapid pacing. RESULTS: A total of 12 patients (9 male, 3 female), mean age 81 +/- 7 years, EuroSCORE II 9.1 +/- 4.5, underwent TEVAR for the treatment of type A aortic dissection. Procedural success was achieved in 11 of 12 patients (91.7%). There was 1 minor stroke and 1 intraprocedural death. No additional deaths were reported at 30 days. At 36 months, there were 4 further deaths (all from nonaortic causes). The mean survival of these 4 deceased was 23 months (range 15-36 months). Follow-up computed tomography demonstrated favorable aortic remodeling. CONCLUSIONS: TEVAR is feasible and reveals promising early results in selected patients with type A aortic dissection who are poor candidates for surgical repair. The current iteration of stent-graft technology, however, needs to be adapted to features specific to the ascending aorta. [less ▲]

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See detailInhibition of ethylene synthesis reduces salt-tolerance in tomato wild relative species Solanum chilense
Gharbi, E.; Martínez, J.-P.; Benahmed, H. et al

in Journal of Plant Physiology (2017), 210

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of ... [more ▼]

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of Solanum chilense (accession LA4107) and of cultivated glycophyte Solanum lycopersicum (cv. Ailsa Craig) were cultivated for 7 days in nutrient solution containing 0 or 125 mM NaCl in the presence or absence of the inhibitor of ethylene synthesis (aminovinylglycine (AVG) 2 μM). Salt-induced ethylene synthesis in S. chilense occurred concomitantly with an increase in stomatal conductance, an efficient osmotic adjustment and the maintenance of carbon isotope discrimination value (Δ13C). In contrast, in S. lycopersicum, salt stress decreased stomatal conductance and Δ13C values while osmotic potential remained higher than in S. chilense. Inhibition of stress-induced ethylene synthesis by AVG decreased stomatal conductance and Δ13C in S. chilense and compromised osmotic adjustment. Solanum chilense behaved as an includer and accumulated high amounts of Na in the shoot but remained able to maintain K nutrition in the presence of NaCl. This species however did not stimulate the expression of genes coding for high-affinity K transport but genes coding for ethylene responsive factor ERF5 and JREF1 were constitutively more expressed in S. chilense than in S. lycopersicum. It is concluded that ethylene plays a key role in salt tolerance of S. chilense. © 2016 [less ▲]

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See detailDroit matériel européen - recueil de documentation
Van Cleynenbreugel, Pieter ULg

Learning material (2017)

This set of cases and materials contains the key judgments and legislative instruments discussed in the compulsory droit matériel européen course. Judgments are preceded by self-study questions aimed at ... [more ▼]

This set of cases and materials contains the key judgments and legislative instruments discussed in the compulsory droit matériel européen course. Judgments are preceded by self-study questions aimed at facilitating one's understanding of the legal reasoning underlying them. [less ▲]

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See detailSystemic biomarkers of collagen and elastin turnover are associated with clinically relevant outcomes in COPD.
Stolz, Daiana; Leeming, Diana Julie; Edfort Kristensen, Jacob Hull et al

in CHEST (2017)

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic ... [more ▼]

BACKGROUND: Extracellular matrix remodeling (ECM) of the lung tissue releases protein fragments into the blood, where they may be detected as serological surrogate markers of disease activity in chronic obstructive pulmonary disease (COPD). We aimed to assess the association of ECM turnover with severity and outcome of COPD. METHODS: In a prospective, observational, multicenter study including 506 patients with COPD, GOLD grades II-IV, we analyzed serum samples at stable state, exacerbation and 4 weeks after exacerbation, for a panel of 5 novel neo-epitopes including fragments of collagen type-III (C3M) and type-VI (C6M), pro-forms of collagen type-III (Pro-C3) and type-VI (Pro-C6) and neutrophil elastase-generated fragments of elastin (EL-NE) by ELISA. These neo-epitopes were also measured at stable state in a derivation cohort including 100 COPD patients. RESULTS: Serum levels of C3M, C6M, Pro-C3, Pro-C6 and EL-NE were associated with lung function. Patients with the lowest levels of Pro-C3 and Pro-C6 had more severe airflow limitation, hyperinflation, air trapping, and emphysema. Degradation of collagen type-III and -VI was associated with dyspnea. All ECM biomarkers, except Pro-C6, were increased at exacerbation as compared to stable state but, except EL-NE, did not differ between stable state and exacerbation follow-up in the crude and adjusted analyses. In Cox regression adjusted analyses, Pro-C3 was associated with a shorter time to exacerbation (HR 0.72[0.59-0.89] p=0.002) and Pro-C6 with survival (HR 2.09[1.18-3.71], p=0.011). CONCLUSIONS: Serum biomarkers of ECM turnover are significantly associated with disease severity and clinically relevant outcomes in COPD. [less ▲]

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See detailThiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice
Markova, Nataliia; Bazhenova, Nataliya; Anthony, Daniel C et al

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (2017), 75

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling ... [more ▼]

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)-3β. While decreased GSK- 3β activity appears to impair memory, increased GSK-3β activity is associated with the distressed/depressed state. However, direct evidence for the effects of thiamine on GSK-3β function were not have not been reported. Here, we administered thiamine or, the more bioavailable precursor, benfotiamine at 200 mg/kg/day for 2 weeks to C57BL/6J mice, to determine whether treatment might affect behaviours that are known to be sensitive to GSK-3β activity and whether such administration impacts on GSK-3β expression within the brain. The mice were tested in models of contextual conditioning and extinction, a 5-day rat exposure stress test, and a modified swim test with repeated testing. Imipramine (7.5 mg/kg/day) was administered as a positive control for thiamine or benfotiamine. As for imipramine, both compounds inhibited the upregulation of GSK-3β induced by predator stress or repeated swimming, and reduced floating scores and the predator stress-induced behavioural changes in anxiety and exploration. Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step-down avoidance task. Together, our data indicate that thiamine and benfotiamine have antidepressant/anti-stress effects in naïve animals that are associated with reduced GSK-3β expression. Importantly, the treatment also had pro-cognitive actions despite the impact on GSK-3β activity. [less ▲]

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See detailThiamine: Biological forms and function
Bettendorff, Lucien ULg

Conference (2017)

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See detailMechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
Mitrossilis, Démosthène; Röper, Jens-Christian; Roy, Damien Le et al

in Nature Communications (2017), 8

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also ... [more ▼]

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. To mimic physiological tissue deformation with a cell scale resolution, liposomes containing magnetic nanoparticles are injected into embryonic epithelia and submitted to time-variable forces generated by a linear array of micrometric soft magnets. Periodic magnetically induced deformations quantitatively phenocopy the soft mechanical endogenous snail-dependent apex pulsations, rescue the medio-apical accumulation of Rok, Myo-II and subsequent mesoderm invagination lacking in sna mutants, in a Fog-dependent mechanotransductive process. Mesoderm invagination then activates Myo-II apical accumulation, in a similar Fog-dependent mechanotransductive process, which in turn initiates endoderm invagination. This reveals the existence of a highly dynamic self-inductive cascade of mesoderm and endoderm invaginations, regulated by mechano-induced medio-apical stabilization of Myo-II. [less ▲]

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See detailAlgorithm for Temporal Gait Analysis Using Wireless Foot-Mounted Accelerometers
Boutaayamou, Mohamed ULg; Denoël, Vincent ULg; Bruls, Olivier ULg et al

Book published by Springer (2017)

We present a new signal processing algorithm that extracts five gait events: heel strike, toe strike, heel-off, toe-off, and heel clearance from only two accelerometers attached on the heels of the ... [more ▼]

We present a new signal processing algorithm that extracts five gait events: heel strike, toe strike, heel-off, toe-off, and heel clearance from only two accelerometers attached on the heels of the subjects usual shoes. This algorithm first uses a continuous wavelet-based segmentation that parses the signal of consecutive strides into motionless periods defining relevant local acceleration signals. Then, the algorithm uses versatile techniques to accurately extract the five gait events from these local acceleration signals. We validated, on a stride-by-stride basis, the extraction of these gait events by comparing the results with reference data provided by a kinematic 3D analysis system and a video camera. The accuracy and precision achieved by the extraction algorithm for healthy subjects, the reduced number of accelerometer units required, and the validation results obtained, encourage us to further study this system in pathological conditions. [less ▲]

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See detailA surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
Farhat, Khalil; Bodart, Gwennaelle; Martens, Henri ULg et al

in Neuroimmunomodulation (2017)

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See detailEstrogen receptors and estetrol-dependent neuroprotective actions: a pilot study.
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Journal of Endocrinology (2017), 232(1), 85-95

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen ... [more ▼]

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic-ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERalpha (MPP dihydrochloride), ERbeta (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1 mg/kg/day, 5 mg/kg/day, 10 mg/kg/day, 50 mg/kg/day) was investigated using the hypoxic-ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic-ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4's effect was completely blocked by concomitant treatment either with ERalpha and ERbeta inhibitors (MPP and PHTPP, respectively), or ERalpha and ERbeta inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERbeta inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5 mg/kg/day and 50 mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4's antioxidative actions mostly depend on ERalpha and ERbeta, whereas neurogenesis and possibly promyelinating activities might be realized through ERbeta. [less ▲]

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See detailFrançois Ier et les arts du Nord (1515-1547). Des liens à explorer et à appronfondir encore
Fagnart, Laure ULg; Lecocq, Isabelle

in Fagnart, Laure; Lecocq, Isabelle (Eds.) François Ier et les arts du Nord (1515-1547) (2017)

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See detailPest and mould infestation of smoked shrimp and preventive measures for storage in cottage industry
Kpoclou; Anihouvi; Azokpota et al

in Indian Journal of Traditional Knowledge (2017), 16

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See detailJean Clouet vs Joos van Cleve
Fagnart, Laure ULg

in Fagnart, Laure; Lecocq, Isabelle (Eds.) François Ier et les arts du Nord (1515-1547) (2017)

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See detailThe Epoch of Smart Cities and Innovation.
Crutzen, Nathalie ULg; Marolla, Cesar

in Marolla, Cesar (Ed.) Climate Health Risks in Megacities: Sustainable Management and Strategic Planning (2017)

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See detailPost-scriptum à La Misère du monde 25 ans après : Bourdieu, le peuple et son suicide
Cormann, Grégory ULg

in Provenzano, François; Goin, Emilie (Eds.) Usages du peuple (2017)

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See detailOptimized approach to retrieve information on atmospheric carbonyl sulfide (OCS) above the Jungfraujoch station and change in its abundance since 1995
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Vollmer, M. K. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2017), 186

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss ... [more ▼]

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss Alps. More than 200 lines of the nu3 fundamental band of OCS have been systematically evaluated and we selected 4 microwindows on the basis of objective criteria minimizing the effect of interferences, mainly by solar features, carbon dioxide and water vapor absorption lines, while maximizing the information content. Implementation of this new retrieval strategy provided an extended time series of the OCS abundance spanning the 1995-2015 time period, for the study of the long-term trend and seasonal variation of OCS in the free troposphere and stratosphere. Three distinct periods characterize the evolution of the tropospheric partial columns: a first decreasing period (1995-2002), an intermediate increasing period (2002-2008), and the more recent period (2008-2015) which shows no significant trend. Our FTIR tropospheric and stratospheric time series are compared with new in situ gas chromatography mass spectrometry (GCMS) measurements performed by Empa (Laboratory for Air Pollution/Environmental Technology) at the Jungfraujoch since 2008, and with space-borne solar occultation observations by the ACE-FTS instrument on-board the SCISAT satellite, respectively, and they show good agreement. The OCS signal recorded above Jungfraujoch appears to be closely related to anthropogenic sulfur emissions. [less ▲]

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See detailEntrepreneurial teams in social entrepreneurship: When team heterogeneity facilitates organizational hybridity
Dufays, Frédéric ULg; Huybrechts, Benjamin ULg

in Ben-Hafaïedh, Cyrine; Cooney, Thomas (Eds.) Research handbook on entrepreneurial teams: Theory and practice (2017)

This chapter examines the composition of teams involved in social entrepreneurship and more particularly their heterogeneity in terms of “institutional logics”. It proposes that when social welfare and ... [more ▼]

This chapter examines the composition of teams involved in social entrepreneurship and more particularly their heterogeneity in terms of “institutional logics”. It proposes that when social welfare and market logics are integrated within founding teams, such hybridity is likely to infuse the whole entrepreneurial process to ultimately lead to the creation of a social enterprise as a “hybrid” organization. To theorize this process, a model is proposed that examines the implications of entrepreneurial team heterogeneity in social entrepreneurship. It makes clear that complexity and dynamism, in particular with regard to individuals’ social network structure, as well as interactions between team members, are necessary to understand the impact of team composition on the entrepreneurial process. An illustrative case study is presented to demonstrate the practical relevance of the model. [less ▲]

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See detailIntroduction
Masson, Christophe ULg

E-print/Working paper (2017)

Introduction de l'Assemblée générale de Ménestrel – 35e journée d'étude du Réseau des Médiévistes belges de Langue française. Le Moyen Âge dans les (nouveaux) médias. Quelle place pour les médiévistes  ... [more ▼]

Introduction de l'Assemblée générale de Ménestrel – 35e journée d'étude du Réseau des Médiévistes belges de Langue française. Le Moyen Âge dans les (nouveaux) médias. Quelle place pour les médiévistes ? Université de Liège, 7-8 octobre 2016 [less ▲]

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See detailApproche phénoménologique du soi psychopathique
Englebert, Jérôme ULg

in Cormann, Grégory; Boccaccini, Federico (Eds.) Le soi agent : Approches phénoménologiques (2017)

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See detailSustainability and management control. Exploring and theorizing control patterns in large European firms
Crutzen, Nathalie ULg; Zvezdov, Dimitar; Schaltegger, Stefan

in Journal of Cleaner Production (2017), 143

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