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See detailNumerical prediction of resulting rollover shapes and sheared edges after blanking process
Canales Cardenas, Cristian ULg; Boman, Romain ULg; Bussetta, Philippe et al

Conference (2015, April)

Over the years, the simulation of manufacturing processes has introduced several numerical challenges for researchers in computational mechanics. In particular, the numerical modeling of sheet metal ... [more ▼]

Over the years, the simulation of manufacturing processes has introduced several numerical challenges for researchers in computational mechanics. In particular, the numerical modeling of sheet metal blanking process involves different numerical issues that must be carefully treated: a large and highly localized deformation in the shearing zone prior to fracture, complex contact interactions between the tools and the metallic sheet and finally, the ductile failure phenomenon. Despite that this process is one of the most widely used cutting techniques for mass production, the process parameters are normally set by empirical evidence due to the physical complexity resulting from the extreme amount of shearing involved. In addition, the strain-rate dependent behavior of the material must be taken into account due to high punch velocities encountered in practice. Thus, an accurate numerical tool is extremely desirable to optimize the setting parameters of this technique and will lead to a better understanding of the process. [less ▲]

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See detailA comparative study of finite strain formulations in the buckling of cruciform columns
Careglio, Claudio; Canales Cardenas, Cristian ULg; Garcia Garino, Carlos et al

Conference (2015, April)

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See detailPhytochemical Profile and Biological Activity Evaluation of Zanthoxylum heterophyllum Leaves against Malaria
Ledoux, Allison ULg; Mareatefau, Hinerava; Jansen, Olivia ULg et al

in Planta Medica Letters (2015), 2

The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum, an endemic plant from the Mascarene Islands. In vitro antiplasmodial activity of ethyl acetate and ... [more ▼]

The aim of this study was to evaluate the antiplasmodial properties of Zanthoxylum heterophyllum, an endemic plant from the Mascarene Islands. In vitro antiplasmodial activity of ethyl acetate and dichloromethane crude extracts obtained from leaf samples collected on Reunion Island was evaluated on the Plasmodium falciparum 3D7 chloroquine-sensitive strain using a colorimetric method. The major active compound was identified by chromatographic and spectroscopic methods. The best antiplasmodial activity was obtained for the ethyl acetate extract (15 µg/mL < IC50 < 50 µg/mL). The major compound was identified as a sanshool derivative, an alkylamide compound that has moderate antimalarial activity (IC50 = 11.3 µg/mL). This is the first report of the presence of a sanshool derivative in Z. heterophyllum. The moderate antiplasmodial activity of hydroxy-γ-isosanshool was demonstrated for the first time. [less ▲]

See detailTell Beydar, un centre urbain en Djézireh syrienne
Mas, Juliette ULg

Scientific conference (2015, March 31)

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See detailLes attitudes des hétérosexuels envers le mariage et la parentalité des gays et des lesbiennes en Belgique francophone
Scali, Thérèse ULg

Scientific conference (2015, March 31)

Les droits des homosexuels à travers le monde sont en constante évolution. Nonobstant l’important nombre de droits civils qui leur sont accordés en Belgique, la question de l’acceptation sociale des ... [more ▼]

Les droits des homosexuels à travers le monde sont en constante évolution. Nonobstant l’important nombre de droits civils qui leur sont accordés en Belgique, la question de l’acceptation sociale des couples et des familles de gays et de lesbiennes reste posée. L’objectif principal de notre projet est d’examiner les facteurs corrélés à l’acceptation et/ou au rejet du mariage et à la parentalité pour les gays et les lesbiennes. La présente présentation sera axée autour de deux volets : une méthodologie quantitative et une méthodologie qualitative d’analyse des attitudes. En particulier, nous tenterons de démontrer le rôle du genre sur les attitudes et les représentations sociales. Les résultats quantitatifs montrent que les prédicteurs des attitudes positives et négatives sont différents pour les hommes et pour les femmes. Les résultats qualitatifs quant à eux ont mis en lumière les stéréotypes particuliers qui sont encore véhiculés à l’heure actuelle, tant dans la population tout venant, que chez les professionnels de la santé. Enfin, les deux méthodologies ont montré que les attitudes diffèrent envers les gays et les lesbiennes. [less ▲]

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See detailL'avenir de la médecine du travail
Mairiaux, Philippe ULg

Conference given outside the academic context (2015)

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See detailBiomarkers and physiolpathology in the cardiorenal syndrome
BOUQUEGNEAU, Antoine ULg; KRZESINSKI, Jean-Marie ULg; DELANAYE, Pierre ULg et al

in Clinica Chimica Acta (2015), 443

Acute cardiorenal syndrome (CRS) corresponds to an association of acute heart failure and a worsening of renal function. The detection of acute kidney injury (AKI) unfortunately occurs at a late stage of ... [more ▼]

Acute cardiorenal syndrome (CRS) corresponds to an association of acute heart failure and a worsening of renal function. The detection of acute kidney injury (AKI) unfortunately occurs at a late stage of CRS, leading to an increased mortality of the patients. In this review, we described the pathophysiology of CRS and discussed the potential interest of biochemical biomarkers (namely creatinine, cystatin C, NGAL, KIM-1, fatty acid binding protein, Nacetyl-β-D-glucosaminidase and IL-18) that could potentially help to detect AKI earlier and thus reduce the morbi-mortality of the patients suffering from CRS. [less ▲]

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See detailNear-Death Experiences in patients with locked-in syndrome: Not always a blissful journey
Charland-Verville, Vanessa ULg; Lugo, Zulay; Jourdan, Jean-Pierre et al

in Consciousness & Cognition (2015), 34

Memories of Near-Death Experiences (NDEs) most often are recounted as emotionally positive events. At present, no satisfactory explanatory model exists to fully account for the rich phenomenology of NDEs ... [more ▼]

Memories of Near-Death Experiences (NDEs) most often are recounted as emotionally positive events. At present, no satisfactory explanatory model exists to fully account for the rich phenomenology of NDEs following a severe acute brain injury. The particular population of patients with locked-in syndrome (LIS) provides a unique opportunity to study NDEs following infratentorial brain lesions. We here retrospectively characterized the content of NDEs in 8 patients with LIS caused by an acute brainstem lesion (i.e., ‘‘LIS NDEs’’) and 23 NDE experiencers after coma with supratentorial lesions (i.e., ‘‘classical NDEs’’). Compared to ‘‘classical NDEs’’, ‘‘LIS NDEs’’ less frequently experienced a feeling of peacefulness or well-being. It could be hypothesized that NDEs containing less positive emotions might have a specific neuroanatomical substrate related to impaired pontine/paralimbic connectivity or alternatively might be related to the emotional distress caused by the presence of conscious awareness in a paralyzed body. [less ▲]

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See detailProgress on research on rodents and rodent-borne zoonoses in Southeast Asia
Blasdell, Kim; Bordes, Frédéric; Chaisiri, Kittipong et al

in Wildlife Research (2015)

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne ... [more ▼]

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne diseases. Recent studies concerning the Rattini tribe have identified unclear species boundaries that would benefit from further investigation. The development of barcoding may allow more accurate identification of rodents, specifically for complex species. However, knowledge on the distribution and habitat specializations of many common murine rodents is still scarce, particularly regarding the specific habitat preferences of most synanthropic rodent species (Rattus tanezumi or Rattus exulans). Several studies have analyzed the prevalence of major rodent-borne diseases in Southeast Asia and it appears that the greatest risk of rodent zoonoses are in the lowland rainfed and irrigated landscapes, generally in and around rice fields. [less ▲]

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See detailEarly results from the MAVEN mission and the Imaging UltraViolet Spectrograph
Schneider; Stiepen, Arnaud ULg; et al

Scientific conference (2015, March 30)

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See detail"Daqqat al-bashāʾir": réjouissances populaires à l'époque mamelouke
Bauden, Frédéric ULg

Scientific conference (2015, March 30)

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See detailPar A plus B
Deliège, Adrien ULg; Nicolay, Samuel ULg

Conference given outside the academic context (2015)

Exposé de vulgarisation sur l'état de l'art concernant les ondelettes et ses applications, en particulier l'étude du phénomène El Niño.

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See detailOrgan donation after euthanasia on specific patients' request in Belgium
Ysebaert, Y; DETRY, Olivier ULg; Mikhalski, D et al

Conference (2015, March 28)

Euthanasia is banned in almost countries of the world, although in 2002 Belgium legalized it for adults under strict conditions (in a similar way after The Netherlands in 2001. The patient must be in a ... [more ▼]

Euthanasia is banned in almost countries of the world, although in 2002 Belgium legalized it for adults under strict conditions (in a similar way after The Netherlands in 2001. The patient must be in a medically futile condition, of constant and unbearable physical or mental suffering that cannot be alleviated, resulting from a serious and incurable disorder caused by illness or accident. If the person is not in the terminal phase of his illness, the 2 doctors must consult with a third doctor, either a psychiatrist or a specialist in the disease concerned. From 2005 till 2014 more than 25 patients, suffering from diverse neuropsychiatric diseases, got their request for euthanasia granted, and subsequently asked spontaneously for the possibility of organ donation. The involved physicians, the transplant teams and the Institutional Ethics Committees, had the well-discussed opinion that this strong request for organ donation after euthanasia could not be denied. A clear separation between the euthanasia request, the euthanasia procedure and the organ procurement procedure was judged necessary. After extensive preparation, finally, in Belgium, 17 patients got their wish for organ donation after euthanasia fulfilled, in several academic or non-academic hospitals and in different regions : Antwerpen 6, Leuven 5, Liege 2, Namur 1, Turnhout 1, and Brussels 2. Several requests and negotiations were started for other patients but ultimately failed due to patients’ personal choices (e.g. patient wanted finally to die at home) or logistically reasons (e.g. who would fulfil the euthanasia in case all involving doctors were not employed or connected to a hospital). The euthanasia procedure was carried out by three physicians in the neighborhood of the operating room. After clinical diagnosis of cardiac death, the procurement team came in and performed the organ procurement similar as in a DCD type III procedure. The liver, two kidneys and sometimes lungs and pancreatic islets could be successfully recovered and transplanted, after organ allocation via Eurotransplant. Transplant centers were informed about the nature of the case and the elements of organ procurement. There was primary function of all organs. The possibility of organ donation after their euthanasia provides a very much improved self-image of these patients, and adds something really positive to the euthanasia procedure, and is very well appreciated by the requesting patients, relatives, patient and professional organisations and public media. Some practical and ethical issues still have to be discussed to allow expansion of this possibility of organ donation. [less ▲]

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See detailLa promotion de l’activité physique dans les écoles : un projet de société
Cloes, Marc ULg

Conference (2015, March 28)

A l'heure actuelle, les preuves scientifiques existent pour souligner la nécessité de lutter contre la sédentarité. L'école constitue un pilier essentiel de l'action à mettre en oeuvre dans cette ... [more ▼]

A l'heure actuelle, les preuves scientifiques existent pour souligner la nécessité de lutter contre la sédentarité. L'école constitue un pilier essentiel de l'action à mettre en oeuvre dans cette perspective et, en son sein, les enseignants en éducation physique devraient jouer un rôle central en tant que 'pierre angulaire' de la promotion de l'activité physique. Ceci exige toutefois un recentrage de leur intervention sur le développement de citoyens physiquement éduqués, justifiant un changement dans les priorités de leur enseignement. Cela ne peut toutefois pas être mis en oeuvre sans le soutien des autorités scolaires locales et du domaine de la santé. Un axe de travail consiste finalement à éduquer la société en communiquant davantage à propos de ce qui est fait à l'école pour développer un style de vie actif. [less ▲]

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See detailIn the name of Benedetto Varchi: Agnolo Bronzino artist and poet
Geremicca, Antonio ULg

Scientific conference (2015, March 28)

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See detailLa réception du livre italien dans les anciens Pays-Bas à la première modernité : Bilan et perspectives de recherches
Adam, Renaud ULg

Conference (2015, March 28)

Cette communication sera l’occasion pour Renaud Adam de faire un premier bilan des activités menées en Belgique sur la réception du livre italien dans les anciens Pays-Bas aux XVIe et XVIIe siècles depuis ... [more ▼]

Cette communication sera l’occasion pour Renaud Adam de faire un premier bilan des activités menées en Belgique sur la réception du livre italien dans les anciens Pays-Bas aux XVIe et XVIIe siècles depuis le lancement, en novembre 2013, du projet international sur l'Édition italienne dans l'espace francophone à la première modernité (EDITEF). Il présentera notamment les premiers résultats d’une enquête centrée sur la place du livre italien, en langue vulgaire ou en traduction, dans la partie d’expression française des anciens Pays- [less ▲]

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See detailInfusion of third-party mesenchymal stromal cells after liver transplantation: a phase 1, open-label, clinical study
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

Poster (2015, March 27)

Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases ... [more ▼]

Transplanted patients have to deal with numerous side effects of life-long dependence on immunosuppressive drugs. Paradoxically these drugs fail to prevent acute and/or chronic rejection in many cases. Mesenchymal stromal cells (MSC) are multipotent and self-renewing bone marrow progenitors that have been shown both in vitro and in vivo as capable of (i) immunomodulation, (ii) anti-inflammation in case of ischemia/reperfusion injury, and (ii) stimulation of tissue repair. MSC could therefore be very interesting in organ recipients to limit chronic graft damage and to allow tolerance. This study aimed to be the first clinical evaluation of the safety and tolerability of MSC infusion after liver transplantation in a prospective, controlled, phase I study. Clinical grade MSCs were locally collected from the bone marrow of unrelated healthy donors. They were cultured in a GMP-compliant lab, underwent extensive quality controls and were frozen for storage in a MSC bank. When needed for patient treatment, MSC were thawed and intravenously injected into patients. 10 liver transplant recipients under standard immunosuppression (TAC-MMF-low dose steroids until day 30) received 1.5-3x106/kg MSC on post- operative day 3 ± 2. These patients were prospectively compared to a group of 10 control (MSC-) liver recipients. Primary endpoints were MSC infusion toxicity, and incidence of cancer and opportunistic infections at month 6. Secondary endpoints were patient and graft survivals and rejection at month 6, as well as the effects of MSC on recipients’ immune function and on immunohistology of at month 6 graft biopsies. No MSC infusional toxicity was observed. Both groups were comparable in terms of donor and recipient characteristics. There was no difference in primary end-points between control and MSC groups. No patient developed de novo cancer. There was no statistical difference in patient and graft survivals or in rejection rates. There was no graft rejection in the MSC group. Month-6 graft biopsies were not different according to Banff and fibrosis scores. This phase I study showed excellent tolerability and safety of a single infusion of third-party MSC after liver transplantation. There were no graft safety issues and no excess of immunosuppression after MSC injection. Further analyses of consequences of MSC injection on the immune profile are needed. The possibility of avoiding calcineurin-inhibitors with repeated MSC injections as main immunosuppressive therapy and/of tolerance induction by MSC infusion should be investigated by further studies. [less ▲]

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See detailLa collaboration entre différentes disciplines médicales : ou est le problème ? Etude Partnership in Medicine
Vanmeerbeek, Marc ULg; Govers, Patrick ULg; Schippers, Nathalie ULg et al

Conference (2015, March 27)

Objectifs Les maladies ou problèmes médicaux d’origine professionnelle, ou en lien avec le travail, impliquent à des degrés divers les médecins généralistes (MG), les médecins du travail (MT) et les ... [more ▼]

Objectifs Les maladies ou problèmes médicaux d’origine professionnelle, ou en lien avec le travail, impliquent à des degrés divers les médecins généralistes (MG), les médecins du travail (MT) et les médecins-conseils des mutuelles (MC). Le manque de relation fonctionnelle entre eux peut compliquer ou retarder le retour au travail du patient. L’étude cherchait des pistes d’amélioration de la collaboration. Méthode Deux méthodes de consensus ont été successivement utilisées parmi les trois professions : huit groupes nominaux (GN) ont réunis 74 médecins de terrain; deux rondes Delphi ont concerné 28 décideurs. Résultats Un seul médecin a été perdu de vue entre les 2 tours du Delphi. Les propositions issues des GN concernaient le transfert d’informations (surtout les MT et les MC), la collaboration (surtout les MG et les MT), les connaissances, et le cadre légal et réglementaire (surtout les MC). Cinq questions sur 14 n’ont pas fait consensus (≥75%) au 1er tour du Delphi, et 10 propositions sur 13 ont été rejetées au 2e tour. Les désaccords portaient sur la nature des données à transférer, les modalités de transfert d’information, la disponibilité des données de contact des médecins. Un processus d’évitement spécifique a été mis en évidence. Certains commentaires montraient un déni de la capacité des autres à comprendre son champ professionnel, et une difficulté à considérer leur spécificité propre. Conclusions L’étude montre que le patient n’est pas un objet partagé de la relation. Le modèle Resource Dependence Institutional Cooperation (De Rijk) permet de distinguer les entraves à la volonté de coopérer (dépendance perçue) des limitations dans la capacité à le faire (manque de ressources). Le modèle quadridimensionnel de la collaboration (D’Amour) identifie un déficit d’internalisation du côté relationnel (reconnaissance des autres), et un déficit de gouvernance et de formalisation du côté organisationnel, où des initiatives volontaristes des autorités seraient bienvenues. [less ▲]

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