Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailMyoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
Blomme, Arnaud; Costanza, Brunella ULg; De Tullio, Pascal ULg et al

in Oncogene (2016)

Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as ... [more ▼]

Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion of cancer cells. We have previously demonstrated that myoferlin regulates epidermal growth factor receptor activity in breast cancer. In the current study, we report a consistent overexpression of myoferlin in triple-negative breast cancer cells (TNBC) over cells originating from other breast cancer subtypes. Using a combination of proteomics, metabolomics and electron microscopy, we demonstrate that myoferlin depletion results in marked alteration of endosomal system and metabolism. Mechanistically, myoferlin depletion caused impaired vesicle traffic that led to a misbalance of saturated/unsaturated fatty acids. This provoked mitochondrial dysfunction in TNBC cells. As a consequence of the major metabolic stress, TNBC cells rapidly triggered AMP activated protein kinase-mediated metabolic reprogramming to glycolysis. This reduced their ability to balance between oxidative phosphorylation and glycolysis, rendering TNBC cells metabolically inflexible, and more sensitive to metabolic drug targeting in vitro. In line with this, our in vivo findings demonstrated a significantly reduced capacity of myoferlin-deficient TNBC cells to metastasise to lungs. The significance of this observation was further supported by clinical data, showing that TNBC patients whose tumors overexpress myoferlin have worst distant metastasis-free and overall survivals. This novel insight into myoferlin function establishes an important link between vesicle traffic, cancer metabolism and progression, offering new diagnostic and therapeutic concepts to develop treatments for TNBC patients. [less ▲]

Detailed reference viewed: 12 (4 ULg)
Full Text
See detailEvaluation de l'impact socio-économique en aval des aménagements hydroélectriques : exemple du barrage hydroélectrique de Nam Mang 3 au Laos
Kouangpalath, Phimthong ULg

Doctoral thesis (2016)

Since two decades, hydropower projects are multiplying in Laos. These projects are often criticized in the media and civil society organizations for their negative social and environmental impacts, which ... [more ▼]

Since two decades, hydropower projects are multiplying in Laos. These projects are often criticized in the media and civil society organizations for their negative social and environmental impacts, which can also generate regional geopolitical tensions in Southeast Asia. In this sensitive context, our interest has focused on rural populations downstream of hydropower dams; these populations are often ignored by compensation programs reserved for displaced populations from upstream. The objective of the research is to identify and assess the socio-economic effects in the Nam Nyam Valley (Vientiane Province, Lao PDR), downstream of the Nam Mang 3 hydropower dam. A current diagnostic-analysis of the agrarian system of the valley, together with a characterization of the recent evolution was conducted by household surveys in different villages. The diachronic study of agrarian dynamics and understanding the links of causality enabled us to model a counterfactual scenario to isolate, by difference with the current situation (scenario "with project"), the specific effects of the dam. In parallel, a similar approach was employed downstream of the Nam Lik 1-2 hydropower dam in the Meuang Feuang basin (Vientiane province, Lao PDR) in order to compare with the results of the Nam Nyam Valley, to better characterize the specific effects of hydropower infrastructure developments. As a result, the evolution of agrarian systems in the valleys downstream depends on the combination, variable over time, of several political, economic, demographic, environmental, technical, social, etc. factors. A hydropower dam, like the one of Nam Mang 3 is part of complex and continuous dynamics of transformation; its impact is not only the sole cause of changes affecting the communities. The socio-economic effects influence over time a much larger population downstream than upstream, even if the media attract the attention on punctual displacement of villages (and their compensation) to fill the reservoir. The hydropower dam project effects differ according to phases (construction, reservoir filling, operation) and social categories, depending on the investment capacities, adaptation and networks of each category. The socio-economic impact downstream is not assumed to be correlated with the size of hydropower dam, but its design and mode of water management are the key criteria of the importance of negative externalities. The massive investments in these projects have also positive effects for the local population, such as the development of local infrastructure, which open up villages and provide access to public services and markets. However, these positive externalities mainly concern well-off villagers disposing of capital and networks to benefit of new opportunities, while poor families are more vulnerable to changes in the political, environmental, technical and socio-economic context. Thus, hydropower dams contribute to increased socio-economic differentiation in villages downstream, with the poor left out of the profits from the energy export. [less ▲]

Detailed reference viewed: 29 (9 ULg)
Full Text
Peer Reviewed
See detailSU(3) Clebsch-Gordan coefficients at large $N_c$
Stancu, Floarea ULg

in Nuclear Physics A (2016), 945

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic ... [more ▼]

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic formulae derived by Hecht in 1965 in the context of nuclear physics. This is valid for irreducible representations with multiplicity one in the corresponding Clebsch-Gordan series. For multiplicity two, Hecht has proposed an alternative which can provide correct $1/N_c$ sub-leading orders in large $N_c$ studies. [less ▲]

Detailed reference viewed: 32 (4 ULg)
See detailLe clergé à Eupen-Malmedy durant l'entre-deux-guerres
Brüll, Christoph ULg

Conference given outside the academic context (2016)

Depuis les premières publications sur l’évolution dans les territoires devenus belges en 1920, on sait que le clergé y avait un rôle politique important dans les débats politiques tendus de l’entre-deux ... [more ▼]

Depuis les premières publications sur l’évolution dans les territoires devenus belges en 1920, on sait que le clergé y avait un rôle politique important dans les débats politiques tendus de l’entre-deux-guerres. Comme le reste de la population, il est tiraillé entre deux patries – Belgique et Allemagne –, mais il l’est surtout aussi entre deux évêchés – Liège et Cologne. L’expérience des prêtres dans la région frontalière belgo-allemande illustre alors, parfois douloureusement, le champ de tension entre l’aspiration universelle de l’Église catholique et les convictions national(ist)es de ceux qui la représentent sur place. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
See detailModéliser pour comprendre les phénomènes
Karous, Hamad ULg; Nihant, Brigitte ULg; Leyh, Bernard ULg

Conference (2016, October 22)

Il existe actuellement un consensus sur le fait que les scientifiques ne décrivent pas la réalité telle qu’elle est dans toute sa complexité mais qu’ils en construisent des représentations qui leur ... [more ▼]

Il existe actuellement un consensus sur le fait que les scientifiques ne décrivent pas la réalité telle qu’elle est dans toute sa complexité mais qu’ils en construisent des représentations qui leur permettent de l’expliquer partiellement et de la maîtriser, partiellement également. De telles représentations sont généralement appelées des modèles et le processus de leur construction est la modélisation. Les référentiels et programmes de sciences insistent de plus en plus, dans un souci d’authenticité épistémologique, sur la nécessité de confronter les élèves aux modèles établis et à leur élaboration, afin qu’ils se constituent une vision aussi fidèle que possible de l’entreprise scientifique. Le concept de modèle possède des composantes multiples et il n’est pas aisé d’en donner une définition compacte, complète et définitive. On pourrait tenter de dire, en bref, que modéliser, c’est simplifier délibérément pour pouvoir expliquer et agir efficacement. On peut envisager différents types de modèles qui ne s’excluent pas mutuellement. On les rencontrera dans les différentes activités expérimentales que nous proposons. (i) On peut tout d’abord modéliser une situation expérimentale complexe (une pile commerciale ou un accumulateur, par exemple) par une autre situation apparentée mais plus simple et dont on contrôle mieux les paramètres, afin de mettre leur influence en lumière. Diverses expériences sur les piles (de Daniell, entre autres) illustrent cet aspect. Les expériences proposées sur la diffusion entrent également dans cette catégorie. (ii) En chimie, le principe explicatif fondamental consiste à fonder les observations macroscopiques sur des processus décrits au niveau sub-microscopique (atomes, molécules, ions, électrons). Cette représentation sub-microscopique peut être schématique et/ou symbolique. Pour plusieurs des expériences proposées, on demande de représenter schématiquement les mouvements des particules concernées. On demande aussi de traduire le phénomène en un langage symbolique, l’écriture de la réaction chimique. Ici aussi, il s’agit d’une modélisation : quand on écrit HCl(aq), par exemple, on remplace une situation complexe et relativement mal définie – des ions H3O+ et des ions Cl- hydratés avec éventuellement plusieurs couches d’hydratation – par une écriture compacte qui représente de manière conventionnelle l’essentiel de l’information dont on a besoin dans un but déterminé (un titrage, par exemple). [less ▲]

Detailed reference viewed: 17 (1 ULg)
See detailConclusions
Dozo, Björn-Olav ULg; Philippette, Thibault; Servais, Olivier

Conference (2016, October 22)

Detailed reference viewed: 12 (0 ULg)
See detailGeorges Truffaut et la modernisation de la cité
Charlier, Sébastien ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailImpact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
LAMBERT, France ULg; Bacevic, Miljana ULg; Layrolle, Pierre et al

in Clinical Oral Implants Research (2016)

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite ... [more ▼]

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite-based biomaterials (HA) of different origins (natural or synthetic) or manufacturing process in a sinus lift model in rabbits. The secondary objective was to correlate the findings with the physical and topographical characteristics of the biomaterials. Materials and Methods: Two bovine HA manufactured with different processes (bovine hydroxyapatites [BHA] and cuttlebone hydroxyapatite [CBHA]) and a synthetic hydroxyapatite (SHA) sintered at high temperature were characterised with scanning electronic microscopy (SEM) and the measurement of specific surface area (BET). The materials were implanted in a sinus lift model in rabbits; histological and histomorphometric evaluation using non-decalcified sections was performed at 1, 5 and 12 weeks after implantation. Results: The studied biomaterials displayed a different surface topography. The two natural HA displayed significantly higher bone quantities (P = 0.0017; BHA vs. SHA, P = 0.0018 and CBHA vs. SHA, P = 0.033) at 5 and 12 weeks compared to the synthetic one (SHA). Moreover, the osteoconductivity (bone-to-material contact) was significantly higher in the BHA group compared to the two other groups (P = 0.014; BHA vs. SHA, P = 0.023 and BHA vs. CBHA, P = 0.033). Conclusion: HA-based biomaterials from diverse origins and manufacturing processes displayed different topographical characteristics. This may have influenced different regenerated bone architecture observed; more bone was found with natural HA compared to the synthetic one, and significantly higher bone-to-material contacts were found with BHA. [less ▲]

Detailed reference viewed: 23 (1 ULg)
See detailMathias Enard, traducteur nomade
Bada, Valérie ULg

Speech/Talk (2016)

A travers 4 traductions de Mathias Enard (deux poèmes issus de la tradiction littéraire obscène persane et arabe du 19e s, ainsi qu'un récit autobiographique traduit de l'arabe du Liban et un recueil de ... [more ▼]

A travers 4 traductions de Mathias Enard (deux poèmes issus de la tradiction littéraire obscène persane et arabe du 19e s, ainsi qu'un récit autobiographique traduit de l'arabe du Liban et un recueil de nouvelles traduites du castillan), le rapport à la langue de traduction et à sa langue de création littéraire est évoqué ainsi que l'intervention créative dans le texte traduit. Est évoquée également la visibilité du traducteur à travers la préface et la postface de ses traductions. [less ▲]

Detailed reference viewed: 50 (0 ULg)
Full Text
See detailLa pubalgie - Rééducation post-chirurgicale
Delvaux, François ULg; DANIEL, Christophe ULg; NAMUROIS, Marie-Hélène ULg et al

Conference (2016, October 22)

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailDevelopment of an analytical method for the simultaneous measurement of 10 biogenic amines in food
Douny, Caroline ULg; Benmedjadi, Soumaya; Blaszczyk, Marie et al

Poster (2016, October 21)

Detailed reference viewed: 30 (8 ULg)
Full Text
See detailQuand le plan zonal de sécurité rencontre la police locale Analyse sociologique du processus de traduction d'un artefact d'action publique
Croquet, Alice ULg

Doctoral thesis (2016)

The thesis examines the implementation of a security policy introduced by the 1998 Belgian police reform through the public policy instrument that declines the latter on local level, that is the area ... [more ▼]

The thesis examines the implementation of a security policy introduced by the 1998 Belgian police reform through the public policy instrument that declines the latter on local level, that is the area security plan. The thesis is based on four case studies and crossed inputs from the Actor-Network Theory and the Sociology of organized action. It traced the career of the area security plan in the local police organizations as the construction of a “sociotechnical system”. We analyze the work of mutual translation that occurs between the instrument and the police environment around four “events” making them progressively irreversible. On the one hand, we discover the “turbulent” nature of the regulatory control within police organizations. On the other hand, we settle the performative nature of the area security plan, of which we consider the introduction in the police landscape as an artifact at the service of the structural compromise that has been stabilized since the reform. [less ▲]

Detailed reference viewed: 36 (2 ULg)
Full Text
See detailSurgical treatment of mucometra in an Alpine Goat.
Casalta, Hélène ULg; Knapp, Emilie ULg; Evrard, Laurence ULg et al

Poster (2016, October 21)

Detailed reference viewed: 15 (3 ULg)
See detailLung resident eosinophils represent a distinct cell subset with homeostatic functions
Mesnil, Claire ULg; Raulier, Stéfanie ULg; Paulissen, Geneviève et al

Conference (2016, October 21)

Detailed reference viewed: 20 (3 ULg)
See detailBelgian Heterosexuals’ Attitudes towards Gay and Lesbian Couples and Same-sex Parenting
Scali, Thérèse ULg

Doctoral thesis (2016)

The legal situation of Belgian gay men and lesbians may be perceived as one of the best in Europe. Indeed, the Belgian Parliament has legalized marriage and parenting for same-sex couples, has enacted ... [more ▼]

The legal situation of Belgian gay men and lesbians may be perceived as one of the best in Europe. Indeed, the Belgian Parliament has legalized marriage and parenting for same-sex couples, has enacted anti-discrimination laws, and has designed and funded several action plans to combat homophobia. Since the opening up of marriage to same-sex couples in 2003, around a thousand gay and a thousand lesbian marriages are celebrated each year in Belgium (Direction Générale Statistique et Information Économique, 2015). Moreover, since the legalization of parenthood for gay men and lesbians, more and more same-sex couples adopt children or resort to artificial insemination, and the total number of children growing up with same-sex parents is growing steadily. Thus, a new reality is emerging: the reality of same-sex headed families. However, in spite of the civil rights granted to gay men and lesbians, the issue of social acceptance of same-sex couples and their children still remains and Belgium continues to record increasing levels of violence against homosexual people. Therefore, the main objective of the present thesis was to explore Belgian heterosexuals’ attitudes towards same-sex marriage and same-sex parenting. The first goal was to investigate the social and personal factors that may be associated with positive and negative attitudes towards same-sex marriage and those towards same-sex parenting (Study 1). The results of self-report questionnaires (N = 1168) revealed that the general attitude towards gay men and lesbians, gender-role traditionalism, beliefs in the origin of homosexuality, representations about child well-being and contact are major predictors of attitudes towards gay and lesbian civil rights. Moreover, results revealed that attitudes differed according to participant’s gender (heterosexual men are less supportive of both same-sex marriage and same-sex parenting than heterosexual women). The respective role of several variables was also discussed (gender-role traditionalism, beliefs in the origin of homosexuality, general attitudes towards gay men and lesbians, representations of child well-being and contact). We demonstrated that increasing intergroup contact can help diminish the impact of some personal beliefs on attitudes towards same-sex parenting. Moreover, results revealed that the degree of support differed in regard to the different types of parenthood. Moreover, several authors in the field of social psychology highlighted the role of beliefs and social representations upon attitudes (Dardenne, 2006). Specifically, attitudes towards gay men and lesbians as parents seem to be somehow beliefs-based (Costa, 2013). Our next objectives were to explore the arguments in favour and against same-sex parenting, both in the general population through the comments posted on social networks (Study 2) and with health-care professionals working in family counselling centres (Study 3). Both studies highlighted positive and negative arguments, each linked to one of the following category: societal and legal context, religiosity, contact, representations of homosexuality, gender-role traditionalism, general attitudes towards gay men and lesbians and representations about child well-being. Moreover, a comparative analysis of the two samples allowed us to state that the arguments held by the social workers are quite similar to those held by the citizens in the general population. Thus, we concluded that health-care professionals’ attitudes are based on naïve knowledge rather than on scientific knowledge, and this lack of scientific knowledge on same-sex parenting has an impact not only on social workers’ attitudes but also on their interventions. To conclude, our work demonstrated that, in Belgium, the barriers to accepting rainbow couples and families are no longer legal, but social. Nearly ten years after the law on adoption for same-sex couples, the country remains relatively conservative and traditional in some regards. Therefore, by demystifying and deconstructing ill-conceived ideas, it will be possible to move towards greater acceptance. Thus, more positive attitudes may be reached when in-depth work has taken place on social perceptions, particularly around questions of gender-role traditionalism, the representations of homosexuality and same-sex lifestyle, and around the child’s well-being. In particular, it is important to deconstruct stereotypes about gay men and lesbians and open minds to other possible forms of families. To achieve those goals, the role of intergroup contact is very important. It is, consequently, also down to psycho-social trainers to create homophobia prevention programmes based on tailor-made training sessions, taking into account the specificities of each group and their beliefs. Finally, we recommend that future research focuses upon same-sex parent families, in order to enrich the scientific data available on these families and their experiences. [less ▲]

Detailed reference viewed: 29 (1 ULg)
Peer Reviewed
See detailMallarmé et le “motif commun”
Durand, Pascal ULg

Conference (2016, October 21)

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailCHAUCER (GEOFFREY)
Crépin (†), André; Dor, Juliette ULg

in Parizet, Sylvie (Ed.) La Bible dans les littératures du monde (2016)

Detailed reference viewed: 15 (0 ULg)