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See detailTreacher Collins syndrome: a clinical and molecular study based on a large series of patients.
Vincent, Marie; Genevieve, David; Ostertag, Agnes et al

in Genetics in medicine : official journal of the American College of Medical Genetics (2016), 18(1), 49-56

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically ... [more ▼]

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically characterized by bilateral mandibular and malar hypoplasia, downward-slanting palpebral fissures, and microtia. To date, three genes have been identified in TCS:,TCOF1, POLR1D, and POLR1C. METHODS: We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS. Phenotype-genotype correlations were investigated for 19 clinical features, between TCOF1 and POLR1D, and the type of mutation or its localization in the TCOF1 gene. RESULTS: We identified 92/146 patients (63%) with a molecular anomaly within TCOF1, 9/146 (6%) within POLR1D, and none within POLR1C. Among the atypical negative patients (with intellectual disability and/or microcephaly), we identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular. Congenital cardiac defects occurred more frequently among patients with TCOF1 mutation (7/92, 8%) than reported in the literature. CONCLUSION: Even though TCOF1 and POLR1D were associated with extreme clinical variability, we found no phenotype-genotype correlation. In cases with a typical phenotype of TCS, 6/146 (4%) remained with an unidentified molecular defect.Genet Med 18 1, 49-56. [less ▲]

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See detailCombined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Hochberg, M. C.; Martel-Pelletier, J.; Monfort, J. et al

in Ann Rheum Dis (2016), 75(1), 37-44

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind ... [more ▼]

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) conducted in France, Germany, Poland and Spain evaluating treatment with CS+GH versus celecoxib in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score >/=301; 0-500 scale). Patients were randomised to receive 400 mg CS plus 500 mg GH three times a day or 200 mg celecoxib every day for 6 months. The primary outcome was the mean decrease in WOMAC pain from baseline to 6 months. Secondary outcomes included WOMAC function and stiffness, visual analogue scale for pain, presence of joint swelling/effusion, rescue medication consumption, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria and EuroQoL-5D. RESULTS: The adjusted mean change (95% CI) in WOMAC pain was -185.7 (-200.3 to -171.1) (50.1% decrease) with CS+GH and -186.8 (-201.7 to -171.9) (50.2% decrease) with celecoxib, meeting the non-inferiority margin of -40: -1.11 (-22.0 to 19.8; p=0.92). All sensitivity analyses were consistent with that result. At 6 months, 79.7% of patients in the combination group and 79.2% in the celecoxib group fulfilled OMERACT-OARSI criteria. Both groups elicited a reduction >50% in the presence of joint swelling; a similar reduction was seen for effusion. No differences were observed for the other secondary outcomes. Adverse events were low and similarly distributed between groups. CONCLUSIONS: CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months in patients with painful knee osteoarthritis, with a good safety profile. TRIAL REGISTRATION NUMBER: NCT01425853. [less ▲]

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See detailCombining feature extraction methods to assist the diagnosis of Alzheimer’s disease
Segovia, Fermin; Gorriz, J. M.; Ramirez, J. et al

in Current Alzheimer Research (2016)

Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the ... [more ▼]

Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the diagnosis of the patients. Modern computer aided diagnosis (CAD) systems based on the statistical analysis of whole neuroimages are more accurate than classical systems based on quantifying the uptake of some predefined regions of interests (ROIs). In addition, these new systems allow determining new ROIs and take advantage of the huge amount of information comprised in neuroimaging data. A major branch of modern CAD systems for AD is based on multivariate techniques, which analyse a neuroimage as a whole, considering not only the voxel intensities but also the relations among them. In order to deal with the vast dimensionality of the data, a number of feature extraction methods have been successfully applied. In this work, we propose a CAD system based on the combination of several feature extraction techniques. First, some commonly used feature extraction methods based on the analysis of the variance (as principal component analysis), on the factorization of the data (as non-negative matrix factorization) and on classical magnitudes (as Haralick features) were simultaneously applied to the original data. These feature sets were then combined by means of two different combination approaches: i) using a single classifier and a multiple kernel learning approach and ii) using an ensemble of classifier and selecting the final decision by majority voting. The proposed approach was evaluated using a labelled neuroimaging database along with a cross validation scheme. As conclusion, the proposed CAD system performed better than approaches using only one feature extraction technique. We also provide a fair comparison (using the same database). - See more at: http://www.eurekaselect.com/136992/article#sthash.PPiyE35K.dpuf [less ▲]

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See detailNew Insight on the Performance of Equity Long/short Investment Styles
Fays, Boris ULg; Hübner, Georges ULg; Lambert, Marie ULg

in Bankers, Markets, Investors (2016), 140(January-February), 34-45

Long-short equity strategies have recently generated exceptional performance raising a set of concerns about the strategies’ propensity to deliver alpha or beta. This paper revisits the performance of ... [more ▼]

Long-short equity strategies have recently generated exceptional performance raising a set of concerns about the strategies’ propensity to deliver alpha or beta. This paper revisits the performance of equity long-short hedge funds across investments styles. We first categorize individual hedge funds with regard to their size and/or value factor investing along the generalization of Sharpe (1992) style analysis. Style weights on size and value factors are used to split the equity long-short universe in 5x5 hedge fund style portfolios. To analyze the performance of each style, we consider two sets of innovative factors. First, we apply sequential Fama-French model of Lambert, Fays and Hübner (2015). Besides, to captures downside and extreme risk embedded in hedge fund strategies we augment the model with the co-skewness and co-kurtosis factors developed by Lambert and Hübner (2013). Under this framework, we perform cross-sectional performance analyses of individual hedge funds as well as time-series analysis on the hedge fund style broad category. Our contributions are threefold; first, our alternative framework significantly improves the explanatory power of the multi-factor model in the context of long-short equity funds, second, considering higher-moment factors aim to capture part of the abnormal return of the downside and extreme risk exposures taken by a fund manager, and finally, long-short equity hedge funds are, to some extent, less exposed to small capitalisation stocks than expected and instead rather prefer higher momentum levels in their strategies. [less ▲]

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See detailManaging the 'Overall Integrated Security Policy' at the local level: An Analysis of inter-institutional Dialogue
Croquet, Alice ULg; Schoenaers, Frédéric ULg

in Hondeghem, Annie; Rousseaux, Xavier; Schoenaers, Frédéric (Eds.) Modernization of the Criminal Justice Chain and the Judicial System. New Insights on Trust, Cooperation and Human Capital (2016)

Building on the heuristic principles of Sociology of Organised Action, this chapter aims to analyse the inter-institutional conception of Area Security Plans in Belgium. This collective decision takes the ... [more ▼]

Building on the heuristic principles of Sociology of Organised Action, this chapter aims to analyse the inter-institutional conception of Area Security Plans in Belgium. This collective decision takes the form of successive informal dialogue steps, culminating in ratification at the legal body originally instituted for the purpose of dialogue. Considering the concept of ‘apparent consensus’ and its conditions of implementation allows us to reveal the plural nature of collective decision-making when realised in practice. [less ▲]

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See detailPapillomaviruses and cervical neoplasia
Herfs, Michael ULg; Chang, Martin; Crum, Christopher

in Holland-Frei Cancer Medicine, ninth edition (2016)

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See detailChemical constituents from Erythrina droogmansiana (Fabaceae), radical scavenging and antibacterial potential of some extracts and compounds
Talla, Emmanuel; Yaya Gbaweng, Joël; Mokale, Laurel et al

in Natural Products : An Indian Journal (2016), 12(1), 12-20

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2 ... [more ▼]

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2), erythrinasinate A (3), erythrinasinate B (4), abyssinone-IV-4'-methylether (5), erythrabyssin (6), phaseollidin (7), 4’-methoxylicoflavanone (8) and abyssinone-V-4'-methylether (9) respectively from methanolic extract of roots wood and EtOAc extract of roots bark of the same plant. Their structures were elucidated using spectroscopic methods (MS, NMR and IR) and by comparison with some data found in literature. Free radical scavenging (DPPH) and antibacterial potentials of extracts and compounds were also evaluated in this work. For radical scavenging, results showed that it is phaseollidin (7) which is responsible of radical scavenging potential in the ethyl acetate extract of roots barks with value of 1.31 mg/ml; for antibacterial, one of the tested compounds abyssinone-IV-4'-methylether (5) exhibited antibacterial activities against two strains: Providencia stuartiiATCC 29916 and Enterobacter aerogenes ATCC 13048 with MIC values of 25μg/ml. [less ▲]

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See detailReconstruction of the Schmallenberg virus epidemic in Belgium: Complementary use of disease surveillance approaches
Poskin, A; Theron, Léonard ULg; Hanon, JB et al

in Veterinary Microbiology (2016), 183

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See detailMétamémoire, fonctions exécutives et performance mnésique
Geurten, Marie ULg

Conference (2016)

L’objectif de cette recherche est d’examiner le développement des habiletés métacognitives au cours de l’enfance, en prêtant une attention particulière aux variables et processus impliqués dans ... [more ▼]

L’objectif de cette recherche est d’examiner le développement des habiletés métacognitives au cours de l’enfance, en prêtant une attention particulière aux variables et processus impliqués dans l’acquisition des connaissances concernant le fonctionnement général de la cognition. Précisément, le but de cette étude est de démontrer l’impact des atteintes exécutives résultant d’un traumatisme crânien sur le développement des connaissances explicites des enfants en métamémoire. Dans ce but, 22 enfants (âgés de 7 à 14 ans) ayant subi un traumatisme crânien modéré à sévère ont été recrutés et divisés en deux groupes en fonction de la gravité de leurs atteintes exécutives (déterminée par le score obtenu à une épreuve d’inhibition, de flexibilité et de mémoire de travail). Au total, dix enfants constituaient le groupe ne montrant pas d’altération du fonctionnement tandis que douze enfants constituaient le groupe montrant des altérations significatives du fonctionnement exécutif. Les deux groupes de patients étaient équivalents à tous les autres niveaux du fonctionnement cognitif. Chaque patient a également été apparié à deux enfants contrôles (n = 44) en fonction de l’âge et du niveau socio-économique. Conformément à l’hypothèse généralement avancée dans la littérature concernant le rôle des fonctions exécutives dans l’apprentissage des connaissances métacognitives au cours de l’enfance, les résultats montrent une différence significative entre les deux groupes de patients au niveau des scores à l’échelle de métamémoire. De même, de moins bonnes performance à l’échelle de métamémoire sont observées pour le groupe de patients démontrant une atteinte exécutive comparativement au groupe d’enfants contrôles. Aucune différence n’était observée entre le groupe de patients ne démontrant pas d’atteinte exécutive et le groupe contrôle. Ces différents résultats suggèrent l’implication des fonctions exécutives dans l’acquisition des connaissances en métamémoire au cours de l’enfance. L’implication de ces résultats pour la prise en charge des patients souffrant de déficits exécutifs sera discutée. [less ▲]

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See detailAlain au prisme de l’ontologie phénoménologique. Relectures croisées d'Alain et de Sartre
Cormann, Grégory ULg

in Depraz, Natalie (Ed.) Alain philosophe rouennais (2016)

Parmi les grands représentants de la « génération 1905 », selon l’expression de J.-F. Sirinelli, Sartre passe pour celui qui a refusé l’enseignement d’Alain alors que des penseurs aussi différents qu’Aron ... [more ▼]

Parmi les grands représentants de la « génération 1905 », selon l’expression de J.-F. Sirinelli, Sartre passe pour celui qui a refusé l’enseignement d’Alain alors que des penseurs aussi différents qu’Aron, Canguilhem ou Hyppolite acceptaient, au moins pour un temps, l’enseignement du maître. Cette appréciation expéditive ne fait droit ni à ce qu’on sait aujourd’hui des premières tentatives philosophiques de Sartre ni au travail inlassable de relecture d’Alain que Sartre aura mené, en sous-main, tout au long de sa trajectoire intellectuelle. Dans cet article, on procédera dès lors, d’une part, au repérage de l’influence d’Alain dans une série de textes, souvent posthumes, qui passent pour des textes préparatoires aux grandes œuvres. On montrera, d’autre part, que cette influence d’Alain s’insinue jusqu’au cœur de l’ontologie phénoménologique de Sartre, dans L’être et le néant, puis dans les prolongements que Sartre y a donnés dans ses psychanalyses existentielles. Au total, on montrera que la plupart des interprétations récentes de Sartre (Coorebyter, Breeur, Gély, Giovannangeli, J. Simont, etc.), depuis une dizaine d’années, se resserrent autour de la relation largement insoupçonnée que l’ontologie phénoménologique sartrienne entretient avec la pensée d’Alain. [less ▲]

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See detailHosios - A Semantic Study of Greek Piety
Peels, Saskia ULg

Book published by Brill, Mnemosyne Supplements (2016)

In HOSIOS – A Semantic Study of Greek Piety Saskia Peels elucidates the semantics of the Ancient Greek adjective hosios and its cognates. Traditionally rendered as ‘piety’, hosios was a key notion in ... [more ▼]

In HOSIOS – A Semantic Study of Greek Piety Saskia Peels elucidates the semantics of the Ancient Greek adjective hosios and its cognates. Traditionally rendered as ‘piety’, hosios was a key notion in Classical Greek religion and reflected a core value in Athenian democracy. Since antiquity, its meaning and usage have puzzled many. This study sets out to resolve various scholarly debates on the semantics of hosios by focusing on the idea of lexical competition. It illuminates the semantic relationship between hosios and its near-synonyms eusebês and dikaios, and the connection to the notion of the ‘sacred’. Using insights from modern linguistic theory, the book also aims to improve methods for research into the lexical semantics of a dead language. [less ▲]

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See detailInvolvement of Executive Functions in Children’s Metamemory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2016), 30(1), 70-80

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]

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See detailDe la thérapeutique à la cosmétique : le verbe στιμμίζειν dans les écrits médicaux grecs
Marganne, Marie-Hélène ULg

in Boudon-Millot, Véronique; Labonnelie-Pardon, Muriel (Eds.) Le teint de Phrynè. Thérapeutique et cosmétique dans l'Antiquité. Paris, Maison de la Recherche, 14-15 janvier 2016 (2016)

Depuis quand et dans quel(s) contexte(s) le substantif στίμμι (ou στῖμι ou στῖβι) désignant une substance de couleur noire dont le nom est d'origine égyptienne, et le verbe στιμμίζειν (ou στιμίζειν ou ... [more ▼]

Depuis quand et dans quel(s) contexte(s) le substantif στίμμι (ou στῖμι ou στῖβι) désignant une substance de couleur noire dont le nom est d'origine égyptienne, et le verbe στιμμίζειν (ou στιμίζειν ou στιβίζειν, ainsi que le composé ὑποστιμμίζειν) décrivant son application dans la région des yeux, sont-ils attestés dans les écrits médicaux grecs ? C'est à ces questions que l'on s'efforcera de répondre en relevant en outre les justifications thérapeutiques de cette pratique par les médecins. [less ▲]

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See detail"Des Heilands schwarzes Haupt im Dornenstrauch". Celan-Stilisierung und Autorinszenierung in Jean Daives Erzählung "Sous la coupole"
Viehöver, Vera ULg

in Shchyhlevska, Natalia; Waldschmidt, Christine (Eds.) Celan-Referenzen: Prozesse einer Traditionsbildung in der Moderne (2016)

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See detailLes codices médicaux grecs de petit format en parchemin dans l'Egypte byzantine
Marganne, Marie-Hélène ULg

in Davoli, Paola; Pellé, Natascia (Eds.) Studi in omaggio a Mario Capasso (2016)

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See detailRole of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb
Naser, Rayan; Vandenbosch, Renaud ULg; Omais, Saad et al

in Scientific Reports (2016)

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See detailDe l'obscurité comme censure. Proust, Muhlfeld, Mallarmé
Durand, Pascal ULg

in Leclerc, Yvan; Macé, Laurence; Poulouin, Claudine (Eds.) Censure et Critique (2016)

Proust’s paper « Contre l’obscurité » [“Against Obscurity”], published in 1896 by La Revue blanche, has been paid back with to rather rough answers : Lucien Muhlfeld’s paper « Sur la clarté » [“About ... [more ▼]

Proust’s paper « Contre l’obscurité » [“Against Obscurity”], published in 1896 by La Revue blanche, has been paid back with to rather rough answers : Lucien Muhlfeld’s paper « Sur la clarté » [“About Clarity”] and « Le Mystère dans les Lettres » by Mallarmé. One of the very few polemical texts of the poet, the latter paper deals with mechanisms of poetical meaning and reciprocal adjustment of both the literary text and his reader. Three kinds of censorship are at stake here. Censorship by the obscurity (Proust). Censorship of the obscurity (Muhlfeld). Censorship with and for the sake of obscurity (Mallarmé). The whole controversy being placed under the very sign of reading and critical evaluation. [less ▲]

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