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See detailMathematical Modeling of HIV Dynamics After Antiretroviral Therapy Initiation: A Review
Rivadeneira, Pablo; Moog, Claude; Stan, Guy-Bart et al

in BioResearch Open Acces (2014), 3(5), 233-241

This review shows the potential ground-breaking impact that mathematical tools may have in the analysis and the understanding of the HIV dynamics. In the first part, early diagnosis of immunological ... [more ▼]

This review shows the potential ground-breaking impact that mathematical tools may have in the analysis and the understanding of the HIV dynamics. In the first part, early diagnosis of immunological failure is inferred from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This method is supported by clinical research results from an original clinical trial: data just after 1 month following therapy initiation are used to carry out the model identification. The diagnosis is shown to be consistent with results from monitoring of the patients after 6 months. In the second part of this review, prospective research results are given for the design of individual anti-HIV treatments optimizing the recovery of the immune system and minimizing side effects. In this respect, two methods are discussed. The first one combines HIV population dynamics with pharmacokinetics and pharmacodynamics models to generate drug treatments using impulsive control systems. The second one is based on optimal control theory and uses a recently published differential equation to model the side effects produced by highly active antiretroviral therapy therapies. The main advantage of these revisited methods is that the drug treatment is computed directly in amounts of drugs, which is easier to interpret by physicians and patients. [less ▲]

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See detailWP2: Drivers of change at sub-global and local scales
Gillet, Pauline ULg; Vermeulen, Cédric ULg; Boulaud, Anne-Laure et al

Conference (2014, October)

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See detailImproved spectral fitting of nitrogen dioxide from OMI in the 405-465 nm window
van Geffen, J H G M; Boersma, K F; Van Roozendael, M et al

in Atmospheric Measurement Techniques. Papers in Open Discussion (2014), 7

An improved nitrogen dioxide (NO2) slant column density retrieval for the Ozone Monitoring Instrument (OMI) in the 405–465 nm spectral region is presented. Since the launch of OMI on board NASA's EOS-Aura ... [more ▼]

An improved nitrogen dioxide (NO2) slant column density retrieval for the Ozone Monitoring Instrument (OMI) in the 405–465 nm spectral region is presented. Since the launch of OMI on board NASA's EOS-Aura satellite in 2004, DOAS retrievals of NO2 slant column densities have been the starting point for the KNMI DOMINO (v2.0) and NASA SP (v2.1) retrievals. However, recent intercomparisons between NO2 retrievals from OMI and other UV/Vis and limb spectrometers, as well as ground-based measurements, clearly suggested that OMI stratospheric NO2 is biased high. This study revises the OMI NO2 retrieval in detail. The representation of the OMI slit function to convolve high-resolution reference spectra onto the relevant spectral grid is improved. The window used for the wavelength calibration is optimised, leading to much-reduced fitting errors. Ozone and water vapour spectra used in the fit are updated, reflecting the recently improved knowledge on their absorption cross section as documented in the literature. The improved spectral fit also accounts for absorption by the O2–O2 collision complex and by liquid water over clear-water areas. The main changes in the improved spectral fitting result from the updates related to the wavelength calibration: the RMS error of the fit is reduced by 23% and the NO2 slant column by 0.85 × 1015 molec cm-2, independent of latitude, solar zenith angle and NO2 value. Including O2–O2 and liquid water absorption and updating the O3 and water vapour cross-section spectra further reduces NO2 slant columns on average by 0.35 × 1015 molec cm-2, accompanied with a further 9% reduction in the RMS error of the fit. The improved OMI NO2 slant columns are consistent with independent NO2 retrievals to within a range that can be explained by photo-chemically driven diurnal increases in stratospheric NO2 and by small differences in fitting window and fitting approach. The revisions indicate that current OMI NO2 slant columns suffered mostly from an additive, positive offset that is removed by the improved wavelength calibration and representation of the OMI slit function. It is therefore anticipated that the improved NO2 slant columns are most important to retrievals of spatially homogeneous stratospheric NO2 rather than to heterogeneous tropospheric NO2. [less ▲]

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See detailThe effect of deforestation rate on land tenure in Central AFrica
Gillet, Pauline ULg; Vermeulen, Cédric ULg; Feintrenie, Laurène

Poster (2014, October)

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See detailImpact of vocal load on breathiness: Perceptual evaluation
Remacle, Angélique ULg; Schoentgen, Jean; FINCK, Camille ULg et al

in Logopedics, Phoniatrics, Vocology (2014), 39(3), 139-146

Objectives: To evaluate the impact on voice of 2 hours of continuous oral reading. Methods: Fifty normophonic women underwent two sessions of voice loading in which the required intensity level varied: 60 ... [more ▼]

Objectives: To evaluate the impact on voice of 2 hours of continuous oral reading. Methods: Fifty normophonic women underwent two sessions of voice loading in which the required intensity level varied: 60-65 dB(A) for the first session, and 70-75 dB(A) for the second session. Ten expert judges evaluated the breathiness of one sentence recorded before and after each loading session. Pairs of stimuli were presented randomly to the judges, who were asked to designate the breathiest sample. Results: A significant decrease in breathiness was observed following both sessions, suggesting an improvement of voice subsequent to loading. When comparing the two intensity levels, no difference was found for breathiness after vocal loading. [less ▲]

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See detailWilderness et Western. L'Ouest fictionnel chez Gustave Aimard et Emilio Salgari
Di Gregorio, Luca ULg

Book published by Presses Universitaires de Liège (2014)

Cet ouvrage pose deux questions relatives aux « matières de l’Ouest » : (1) S’est-il façonné en Europe une imagination propre des Grands Espaces et, si oui, quelles en furent les principales options ... [more ▼]

Cet ouvrage pose deux questions relatives aux « matières de l’Ouest » : (1) S’est-il façonné en Europe une imagination propre des Grands Espaces et, si oui, quelles en furent les principales options éthiques, esthétiques et narratives ? (2) Qu’est-ce qui singularise les thèmes, les intrigues et les personnages privilégiés de cette écriture européenne par rapport à l’imagerie — surexploitée depuis Hollywood — impliquant le cow-boy, le shérif, ou encore les squatters et settlers de la Conquête de l’Ouest ? Le couple wilderness/western — mobilisé ici à des fins dialectiques et non dualistes — débroussaille quelques-unes des pistes herméneutiques d’une production romanesque méconnue. En s’appuyant sur un sous-genre pour ainsi dire oublié du récit aventureux du xixe siècle, l’auteur explore les visages d’un Ouest fictionnel qui, grâce au recul européen, a su se parer d’intéressants lieux d’indépendance et de dynamiques insoupçonnées. Dans l’intervalle entre le wilderness, univers agrégeant l’hygiénisme libertin des Lumières et le spiritualisme romantique, et le western, imaginaire de l’allant national, modelé par et pour l’autonomisation culturelle des USA, mais aussi sous l’effet d’un tiraillement souterrain entre l’exemple colonial français et la Conquête pionnière de l’Ouest, ce sont des oppositions, des débats et des mélanges du plus haut intérêt qui se firent jour dans la France et l’Italie de 1858-1910. Les romans de Gustave Aimard et Emilio Salgari interviennent dans ce contexte, quoiqu’à des titres très différents (l’un grand consolidateur générique, l’autre compositeur original et articulateur d’imaginaires), comme les jalons d’une histoire des formes appropriatives de l’espace-réceptacle ouestien. À bien des égards, un tel parcours ajoute ses sinuosités et ses enjeux spécifiques à l’historiographie strictement américaine : il y apparaît en effet que l’Europe, relativement à l’Ouest, parvint à se faire successivement laboratoire et carrefour imaginaires. [less ▲]

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See detailDesigning large-scale CO2 capture units with assessment of solvent degradation
Léonard, Grégoire ULg; Crosset, Cyril; Dumont, Marie-Noëlle ULg et al

Poster (2014, October)

Solvent degradation is a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. In the present work, we refine a ... [more ▼]

Solvent degradation is a major drawback for the large-scale implementation of post-combustion CO2 capture due to amine consumption and emission of degradation products. In the present work, we refine a previous kinetic model for describing solvent oxidative and thermal degradation based on experimental results. The CO2 capture process is then modeled in Aspen Plus with assessment of solvent degradation. As a result, this work provides a useful tool for the identification of optimal operating conditions that minimize both the energy and environmental impacts of the process. [less ▲]

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See detailFiabilité et confiance
de Saint Georges, Marie-Christine; Haxhe, Stéphanie ULg

Conference (2014, October)

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See detailPrincipes de Reproduction des Petits Camélidés SudAméricains
Hanzen, Christian ULg; Cucho Dolmos, Hernan; Ampuero Casquino, Enrique et al

Book published by Ateliers des Presses de l'ULg (2014)

L’élevage d’alpagas et de lamas constitue une activité économique et sociale importante. Au Pérou, 200.000 familles en dépendent directement ou indirectement au travers de la production d’une fibre et ... [more ▼]

L’élevage d’alpagas et de lamas constitue une activité économique et sociale importante. Au Pérou, 200.000 familles en dépendent directement ou indirectement au travers de la production d’une fibre et d’une viande de qualité. Les petits camélidés ont largement contribué au développement politique et social de l’Empire inca qui comptait pas moins de 12 millions d’habitants. Le Pérou compte 5 millions d’alpagas et de lamas, dont 85 % sont élevés par des petits producteurs selon des méthodes traditionnelles qui se traduisent par des performances de reproduction (50 % des femelles deviennent gravides et la natalité est de 40 %) et de production (la production de laine et le poids de la carcasse sont en moyenne respectivement de 1,5 kg et 20 kg par animal). Pourtant, les petits camélidés constituent un véritable potentiel d’exploitation des pâturages naturels présents entre 4000 et 5000 mètres d’altitude et donc de production de laine et de viande, dont la valeur nutritive est bien réelle puisqu’elle ne renferme que peu de cholestérol et que sa teneur en protéines est respectivement de 24,8 et 21,6 % chez le lama et l’alpaga. Les biotechnologies de la reproduction constituent un outil majeur d’amélioration de la production animale au travers de programmes de sélection génétique. Ainsi, de nombreuses recherches ont permis d’améliorer les méthodes de collecte, d’analyse et de conservation du sperme. Elles se poursuivent dans le domaine de la production in vivo et in vitro et du transfert d’embryons. À terme, elles permettront d’améliorer la productivité des petits camélidés. En 2009, le Conseil Interuniversitaire de la Communauté Française de Belgique (CIUF) et la Commission Universitaire pour le Développement (CUD) ont signé une convention avec l’Université San Antonio Abad del Cusco. Son financement a permis d’équiper la station de recherche de La Raya de la faculté de zootechnie et de réaliser de nombreux travaux de recherche sur la reproduction des alpagas. C’est dans ce contexte et à l’initiative du docteur Christian Hanzen, professeur au service de Thériogénologie des animaux de production de la faculté de médecine vétérinaire de l’Université de Liège, qu’a été réalisé cet ouvrage de synthèse sur les connaissances actuelles en reproduction des petits camélidés, aucun ouvrage n’ayant été publié sur le sujet en langue française ou espagnole. Le livre se décline en sept chapitres à savoir (1) Anatomie et physiologie de la reproduction du mâle ; (2) Prélèvement , analyse et conservation du sperme ; (3) Anatomie de l’appareil génital de la femelle ; (4) Le cycle sexuel ; (5) Les biotechnologies de la reproduction ; (6) La gestation : physiologie, constat et pathologies et (7). La parturition, le postpartum , les pathologies et les performances de reproduction. Il est illustré de 90 figures et 14 tableaux. [less ▲]

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See detailTemplating calcium carbonate drug delivery carriers based on polyphosphoester copolymers
Ergül, Zeynep ULg; Debuigne, Antoine ULg; Calvignac, Brice et al

Poster (2014, October)

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See detailCROSSROADS le magazine sonore des musiques africaines-américaines
Sacré, Robert ULg

Diverse speeche and writing (2014)

Programme radio hebdomadaire consacré aux musiques africaines américaines - www.equinoxefm.be podcasts : www.mixcloud.com/robertsacre9

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See detailHypervitaminémie B12 : un piège diagnostique pour le biologiste et pour le clinicien ?
LUYCKX, Françoise ULg; Texeira, J; VALDES SOCIN, Hernan Gonzalo ULg et al

in Abstract book - Annales d'Endocrinologie : 31ème Congrès de la Société Française d'Endocrinologie, Lyon 5-8 novembre 2014 (2014, October)

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See detailL’ANATOMIE REVISITÉE DU PETIT BASSIN
Bonnet, Pierre ULg

in Louvain Medical (2014), 133(8), 3-13

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des ... [more ▼]

Le petit bassin est un espace cônique musculoosseux comportant la portion inférieure de la cavité péritonéale surmontant l’espace endopelvien. Les viscères pelviens reçoivent leur vascularisation des parois latérales au sein de l’espace endopelvien, leur innervation dépend d’une double origine, abdominale et pelvienne. Les parois de cet espace abritent les nerfs somatiques et vaisseaux destinés aux parois de la partie inférieure du tronc et aux membres inférieurs. La connaissance pratique de cette anatomie peut être aidée par une approche constructive élaborant les parois et ensuite le contenu de cet espace. [less ▲]

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See detailUn univers de perles - Voyage dans le Système solaire au fil d'un collier
Nazé, Yaël ULg

Article for general public (2014)

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See detailTrace element bioaccumulation and compartmentalization in the invasive algae Caulerpa racemosa var. cylindracea from the Calvi Bay, Corsica
Gobert, Sylvie ULg; Richir, Jonathan ULg

in Langar, H.; Bouafif, C.; Ouerghi, A. (Eds.) Proceedings of the 5th Mediterranean Symposium on Marine Vegetation (2014, October)

The algae Caulerpa racemosa var. cylindracea (Sonder) was first observed along Corsican coasts in 2002 (Ruitton et al., 2005), and more recently in the Calvi Bay (northwestern Corsica) in 2008. Numerous ... [more ▼]

The algae Caulerpa racemosa var. cylindracea (Sonder) was first observed along Corsican coasts in 2002 (Ruitton et al., 2005), and more recently in the Calvi Bay (northwestern Corsica) in 2008. Numerous works have studied the distribution of that invasive species and the factors driving its rapid expansion, as well as the resulting ecological impacts on native coastal communities (Klein and Verlaque, 2008). However, very little is known regarding C. racemosa biochemistry and its natural ability to concentrate trace elements (TEs). In the framework of the STARECAPMED project, this work therefore aimed to study the bioaccumulation and the compartmentalization of 19 TEs in this macroalgae. [less ▲]

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See detailMuscle Mitochondrial Dysfunction in Horses Affected by Acute Laminitis
Serteyn, Didier ULg; de la Rebière de Pouyade, Geoffroy ULg; Sandersen, Charlotte ULg et al

in Bioenergetics (2014)

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes ... [more ▼]

Laminitis is a common and debilitating disease affecting horses and ponies. It often leads to the demise of the animal. Energy deficiency is suspected to entrain the disruption of the hemidesmosomes leading to the failure of the dermal-epidermal interface. The aim of this study was to measure the muscle mitochondrial function by high resolution respirometry. Muscle micro-biopsies were obtained from 11 horses affected by acute metabolic laminitis, 6 horses affected by acute laminitis resulting from a systemic inflammation response syndrome and 28 healthy horses distributed in 2 control groups: 17 horses with a body condition score [BSC, ranging from 0 (emaciated) to 5 (obese)] of 2 to 3 and 11 horses with a BSC of 4 to 5. During the acute phase of laminitis, a significant reduction of the muscle mitochondrial respiration was observed. The muscle mitochondrial dysfunction occurred independently of the etiology (metabolic disorder or systemic inflammation) leading to laminitis. The reduction of the oxidative phosphorylation and of the maximal respiratory capacity (after uncoupling) may induce depletion of the cell’s ATP content. If the same mitochondrial alteration occurs in the foot lamina, mitochondria targeting should be considered for the future, not only to better understand the physiopathology of the disease but also to maintain and to support the mitochondrial function before reaching the « mitochondrial dysfunction threshold » that may lead to the failure of the dermal-epidermal interface. [less ▲]

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See detailThe conceptualization of trace element flows within Posidonia oceanica meadows: a collaborative proposal to fill knowledge gaps
Richir, Jonathan ULg; Gobert, Sylvie ULg

in Langar, H.; Bouafif, C.; Ouerghi, A. (Eds.) Proceedings of the 5th Mediterranean Symposium on Marine Vegetation (2014, October)

The Mediterranean seagrass Posidonia oceanica (L.) Delile is regarded as a relevant indicator of bioavailable trace elements (TEs) since it efficiently and proportionally bioaccumulates these chemicals ... [more ▼]

The Mediterranean seagrass Posidonia oceanica (L.) Delile is regarded as a relevant indicator of bioavailable trace elements (TEs) since it efficiently and proportionally bioaccumulates these chemicals from its surrounding environment. Recent studies have further brought supplementary insights in our understanding of the processes driving TE kinetics within that species. But at a higher degree of organization, the distribution and flows of TEs between P. oceanica meadow components, i.e. seagrass shoots, epiphytes, associated algae and animals and detritus, have not been investigated yet. The present study therefore aims to propose a conceptualization model of P. oceanica meadows, regarded as the juxtaposition of the 5 separate components listed above exchanging flows of TEs between themselves and with their environment, i.e. water and sediment. This model can be drawn in energy circuit language. By writing such a model, one in essence is writing equations describing a system. To be relevant, its elaboration requires the compilation of a large amount of quantitative data. This conceptualization can thus be regarded as a collaborative innovation requiring scientists to fill the model through the continuous supplement of new data. In fine, this model will lead to the exact quantification of the role played by P. oceanica meadows in the coastal biogeochemistry of TEsin the Mediterranean. [less ▲]

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See detailL'amiodarone et la thyroïde
Brescia, Lionel ULg; Benoit, Arnaud ULg; BETEA, Daniela ULg et al

in Revue Médicale de Liège (2014), 69(10), 549-554

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See detailLe mystère belge de la translucidité des SCI françaises
Docclo, Caroline ULg

in Tijdschrift voor Fiscaal Recht (2014), (466), 694-697

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