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See detailOptimal Enforcement of Competition Policy: The Commitments Procedure under Uncertainty
Gautier, Axel ULg

Scientific conference (2015, April 09)

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See detailLa génétique de l'acromégalie
Beckers, Albert ULg

Scientific conference (2015, April 09)

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See detailImproved spectral fitting of nitrogen dioxide from OMI in the 405-465 nm window
van Geffen, J H G M; Boersma, K F; Van Roozendael, M et al

in Atmospheric Measurement Techniques (2015), 8

An improved nitrogen dioxide (NO2) slant column density retrieval for the Ozone Monitoring Instrument (OMI) in the 405–465 nm spectral region is presented. Since the launch of OMI on board NASA’s EOS-Aura ... [more ▼]

An improved nitrogen dioxide (NO2) slant column density retrieval for the Ozone Monitoring Instrument (OMI) in the 405–465 nm spectral region is presented. Since the launch of OMI on board NASA’s EOS-Aura satellite in 2004, differential optical absorption spectroscopy (DOAS) retrievals of NO2 slant column densities have been the starting point for the KNMI DOMINO and NASA SP NO2 vertical column data as well as the OMI NO2 data of some other institutes. However, recent intercomparisons between NO2 retrievals from OMI and other UV/Vis and limb spectrometers, as well as ground-based measurements, suggest that OMI stratospheric NO2 is biased high. This study revises and, for the first time, fully documents the OMI NO2 retrieval in detail. The representation of the OMI slit function to convolve high-resolution reference spectra onto the relevant spectral grid is improved. The window used for the wavelength calibration is optimised, leading to much-reduced fitting errors. Ozone and water vapour spectra used in the fit are updated, reflecting the recently improved knowledge of their absorption cross section in the literature. The improved spectral fit also accounts for absorption by the O2–O2 collision complex and by liquid water over clearwater areas. The main changes in the improved spectral fitting result from the updates related to the wavelength calibration: the RMS error of the fit is reduced by 23% and the NO2 slant column by 0.85 1015 molec cm-2, independent of latitude, solar zenith angle and NO2 value. Including O2–O2 and liquid water absorption and updating the O3 and water vapour cross-section spectra further reduces NO2 slant columns on average by 0.35 1015 molec cm-2, accompanied by a further 9% reduction in the RMS error of the fit. The improved OMI NO2 slant columns are consistent with independent NO2 retrievals from other instruments to within a range that can be explained by photochemically driven diurnal increases in stratospheric NO2 and by small differences in fitting window and approach. The revisions indicate that current OMI NO2 slant columns suffered mostly from an additive positive offset, which is removed by the improved wavelength calibration and representation of the OMI slit function. It is therefore anticipated that the improved NO2 slant columns are most important to retrievals of spatially homogeneous stratospheric NO2 rather than to heterogeneous tropospheric NO2. [less ▲]

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See detailEstimated Subglottic Pressure Evaluation, Evolution in 152 Dysphonic Patients
Morsomme, Dominique ULg; Finck, Camille ULg; Larrouy, Pauline ULg

Conference (2015, April 08)

Background: Estimated subglottic pressure (ESGP) is part of the aerodynamic measurements included in the vocal profile. It is an indication of vocal effort. Speyer reports an improvement of the ESGP score ... [more ▼]

Background: Estimated subglottic pressure (ESGP) is part of the aerodynamic measurements included in the vocal profile. It is an indication of vocal effort. Speyer reports an improvement of the ESGP score after voice treatment. Nevertheless, few studies used ESGP to evaluate voice efficiency treatment. Objectives: The purpose is to examine the ESGP twice, at the first (T1) and the last consultation (T2) . We observe the ESGP values according to voice pathology. We also examine the relationships between ESGP, SPL(Sound pressure level) and DSI (Discorder severity index) . Method: The study includes 130 patients (M:31/W:99), which suffer from 4 different pathologies as immobility (N: 54), oedema (N:23), nodules (N:24) and polyp (N:29). Each patient’s file consists of VLS, acoustic, aerodynamic and perceptual measures. The ESGP was collected through the Phonatory Aerodynamic System Model 6600 (KayPentax). Patients produced 3 sequences of / ipipi / at low (IL), conversational (IC) and high (IH) intensity. Patients were grouped according to the ENT’s diagnosis. We compare our values to those of Zraick et al (2012) which studied ESGP on a healthy group. Results: At T2, for the all patients, at minimum and conversational intensity the ESGP scores decrease singificantly, even if those scores were higher than for the healthy group. We observe a negative correlation between ESGP and SPL at low and conversational intensity. At T1, the higher is the ESGP score, the lower is the SPL score. At T2, the higher is the ESGP score, the higher is the SPL score. At T1, a negative correlation is observed between ESGP and DSI for 2 groups of patients (immobility and polyp) only at minimum intensity. The higher is the ESGP, the lower is SPL. At T2, only for the group immobility, the negative correlation persists. Conclusion: This study highlights the importance of considering the ESGP as a parameter of efficiency. High ESGP is mainly connected with patients who suffer from pathology. The patient who suffer from immobility seems to present a specific profile which could help the clinician to better understand their vocal behavior. Recommendation: This study highlights the pertinence of considering the ESGP as a parameter of vocal treatment efficiency. [less ▲]

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See detailState of the art on drivers of deforestation in the Congo basin tropical forest
Gillet, Pauline ULg; Vermeulen, Cédric ULg; Dessard, Hélène et al

Conference (2015, April 07)

The Congo basin forest experiment a low pressure on biodiversity in comparison to other rainforests around the world. But according to the predictions, climate change and direct human drivers could have ... [more ▼]

The Congo basin forest experiment a low pressure on biodiversity in comparison to other rainforests around the world. But according to the predictions, climate change and direct human drivers could have an important effect on the deforestation rate. In that context, CoForTips project want to foster a better management of the Congo Basin forests through a better understanding of the dynamics, regime shifts and tipping points of biodiversity and a better definition of the conditions of resilience of social and ecological systems. In order to assess the current knowledge about drivers of deforestation in the world tropical forests, we analyzed the existent literature to list the direct and indirect drivers of deforestation in the forested tropical zones and to focus on deforestation in the Congo Basin forest and specifically in Cameroon and Gabon. We listed direct drivers of deforestation like expansion of agriculture which can be either family farming or agribusiness; timber extraction for softwood industry and fuel wood; development of infrastructure leading to the opening up of forested land and populations, and mining industries. The underlying causes found in the literature concern economic factors like gross domestic product, national income based on environmental resources exploitation and consumer demand expressing on local and global markets. Technological factors that allow much larger removal. Cultural issues like representation of the forest in the collective imagination as an important source of economic income. Institutional factors like policy measures advocating pro-deforestation measures and demographic causes taking into account for local population rise due to a high fertility rate and linked to population migration. Those direct and underlying causes of deforestation where then detailed for Cameroon and Gabon. [less ▲]

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See detailGCxGC-TOFMS and supervised multivariate approaches to study human cadaveric decomposition olfactive signatures
Stefanuto, Pierre-Hugues ULg; Perrault, Katelynn A.; Stadler, Sonja et al

in Analytical Biochemistry (2015)

In forensic thanato-chemistry, the understanding of the process of soft tissue decomposition is still limited. A better understanding of the decomposition process and the characterization of the ... [more ▼]

In forensic thanato-chemistry, the understanding of the process of soft tissue decomposition is still limited. A better understanding of the decomposition process and the characterization of the associated volatile organic compounds (VOC) can help to improve the training of victim recovery (VR) canines, which are used to search for trapped victims in natural disasters or to locate corpses during criminal investigations. The complexity of matrices and the dynamic nature of this process require the use of comprehensive analytical methods for investigation. Moreover, the variability of the environment and between individuals creates additional difficulties in terms of normalization. The resolution of the complex mixture of VOCs emitted by a decaying corpse can be improved using comprehensive two-dimensional gas chromatography (GC× GC), compared to classical singledimensional gas chromatography (1DGC). This study combines the analytical advantages of GC×GC coupled to timeof- flight mass spectrometry (TOFMS) with the data handling robustness of supervised multivariate statistics to investigate the VOC profile of human remains during early stages of decomposition. Various supervised multivariate approaches are compared to interpret the large data set. Moreover, early decomposition stages of pig carcasses (typically used as human surrogates in field studies) are also monitored to obtain a direct comparison of the two VOC profiles and estimate the robustness of this human decomposition analog model. In this research, we demonstrate that pig and human decomposition processes can be described by the same trends for the major compounds produced during the early stages of soft tissue decomposition. [less ▲]

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See detailEnvironmental constraints drive the partitioning of the soundscape in fishes
Ruppé, Laetitia; Clément, Gaël; Herrel, Anthony et al

in Proceedings of the National Academy of Sciences of the United States of America (2015)

The underwater environment is more and more being depicted as particularly noisy, and the inventory of calling fishes is continuously increasing. However, it currently remains unknown how species share ... [more ▼]

The underwater environment is more and more being depicted as particularly noisy, and the inventory of calling fishes is continuously increasing. However, it currently remains unknown how species share the soundscape and are able to communicate without misinterpreting the messages. Different mechanisms of interference avoidance have been documented in birds, mammals, and frogs, but little is known about interference avoidance in fishes. How fish thus partition the soundscape underwater remains unknown, as acoustic communication and its organization have never been studied at the level of fish communities. In this study, passive acoustic recordings were used to inventory sounds produced in a fish community (120 m depth) in an attempt to understand how different species partition the acoustic environment. We uncovered an important diversity of fish sounds, and 16 of the 37 different sounds recorded were sufficiently abundant to use in a quantitative analysis. We show that sonic activity allows a clear distinction between a diurnal and a nocturnal group of fishes. Moreover, frequencies of signals made during the day overlap, whereas there is a clear distinction between the different representatives of the nocturnal callers because of a lack of overlap in sound frequency. This first demonstration, to our knowledge, of interference avoidance in a fish community can be understood by the way sounds are used. In diurnal species, sounds are mostly used to support visual display, whereas nocturnal species are generally deprived of visual cues, resulting in acoustic constraints being more important. [less ▲]

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See detailRetrieval of ethane from ground-based FTIR solar spectra using improved spectroscopy: recent burden increase above Jungfraujoch
Franco, Bruno ULg; Bader, Whitney ULg; Toon, G. C. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2015), 160(C), 36-49

An improved spectroscopy is used to implement and optimize the retrieval strategy of ethane (C2H6) from ground-based Fourier Transform Infrared (FTIR) solar spectra recorded at the high-altitude station ... [more ▼]

An improved spectroscopy is used to implement and optimize the retrieval strategy of ethane (C2H6) from ground-based Fourier Transform Infrared (FTIR) solar spectra recorded at the high-altitude station of Jungfraujoch (Swiss Alps, 46.5° N, 8.0° E, 3580m a.s.l.). The improved spectroscopic parameters include C2H6 pseudo-lines in the 2720-3100 cm-1 range and updated line parameters for methyl chloride and ozone. These improved spectroscopic parameters allow for substantial reduction of the fitting residuals as well as enhanced information content. They also contribute to limiting oscillations responsible for ungeophysical negative mixing ratio profiles. This strategy has been successfully applied to the Jungfraujoch solar spectra available from 1994 onwards. The resulting time series is compared with C2H6 total columns simulated by the state-of-the-art chemical transport model GEOS-Chem. Despite very consistent seasonal cycles between both data sets, a negative systematic bias relative to the FTIR observations suggests that C2H6 emissions are underestimated in the current inventories implemented in GEOS-Chem. Finally, C2H6 trends are derived from the FTIR time series, revealing a statistically-significant sharp increase of the C2H6 burden in the remote atmosphere above Jungfraujoch since 2009. Evaluating cause of this change in the C2H6 burden, which may be related to the recent massive growth of shale gas exploitation in North America, is of primary importance for atmospheric composition and air quality in the Northern Hemisphere. [less ▲]

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See detailScrivere il compromesso intorno al 1965
Curreri, Luciano ULg

Article for general public (2015)

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See detailPerspective: Tyrosine Phosphatases As Novel Targets For Antiplatelet Therapy
Tautz, Lutz; Senis, Yotis; Oury, Cécile ULg et al

in Bioorganic & Medicinal Chemistry (2015), Epub ahead of print

Arterial thrombosis is the primary cause of most cases of myocardial infarction and stroke, the leading causes of death in the developed world. Platelets, highly specialized cells of the circulatory ... [more ▼]

Arterial thrombosis is the primary cause of most cases of myocardial infarction and stroke, the leading causes of death in the developed world. Platelets, highly specialized cells of the circulatory system, are key contributors to thrombotic events. Antiplatelet drugs, which prevent platelets from aggregating, have been very effective in reducing the mortality and morbidity of these conditions. However, approved antiplatelet therapies have adverse side effects, most notably the increased risk of bleeding. Moreover, there remains a considerable incidence of arterial thrombosis in a subset of patients receiving currently available drugs. Thus, there is a pressing medical need for novel antiplatelet agents with a more favorable safety profile and less patient resistance. The discovery of novel antiplatelet targets is the matter of intense ongoing research. Recent findings demonstrate the potential of targeting key signaling molecules, including kinases and phosphatases, to prevent platelet activation and aggregation. Here, we offer perspectives to targeting members of the protein tyrosine phosphatase (PTP) superfamily, a major class of enzymes in signal transduction. We give an overview of previously identified PTPs in platelet signaling, and discuss their potential as antiplatelet drug targets. We also introduce VHR (DUSP3), a PTP that we recently identified as a major player in platelet biology and thrombosis. We review our data on genetic deletion as well as pharmacological inhibition of VHR, providing proof-of-principle for a novel and potentially safer VHR-based antiplatelet therapy. [less ▲]

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See detailMarques actives utilisées en télémétrie "poissons"
Tétard, Stéphane; Ovidio, Michaël ULg; Capra, Hervé et al

Scientific conference (2015, April 03)

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See detailTree models with Scikit-Learn: Great models with little assumptions
Louppe, Gilles ULg

Conference (2015, April 03)

This talk gives an introduction to tree-based methods, both from a theoretical and practical point of view. It covers decision trees, random forests and boosting estimators, along with concrete examples ... [more ▼]

This talk gives an introduction to tree-based methods, both from a theoretical and practical point of view. It covers decision trees, random forests and boosting estimators, along with concrete examples based on Scikit-Learn about how they work, when they work and why they work. [less ▲]

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See detailLire le futur du passé: villes et paysages de Meuse en projet
Occhiuto, Rita ULg

Conference (2015, April 03)

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See detailQuand la science se mêle de la gestion des eaux pluviales : Les services écosystémiques rendus par l'infrastructure verte
Maréchal, Justine ULg

Conference given outside the academic context (2015)

L'infrastructure verte joue un rôle dominant dans nos villes. Que ce soit d'un point de vue économique, environnemental ou social, chaque fois, cette infrastructure se révèle d'une importance cruciale. La ... [more ▼]

L'infrastructure verte joue un rôle dominant dans nos villes. Que ce soit d'un point de vue économique, environnemental ou social, chaque fois, cette infrastructure se révèle d'une importance cruciale. La présentation s'intéressera dans un premier temps à comprendre les caractéristiques de cette infrastructure verte dans différentes villes belges. Dans un deuxième temps, un parallèle sera fait entre cette structure spatiale des espaces verts et un processus écologique bien précis : la gestion de l'eau pluviale. Pour aborder cette partie, une synthèse de différentes techniques d'aménagement du paysage seront présentées en tant que pistes de réflexion pour une gestion plus intégrée de l'eau de pluie en ville. [less ▲]

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See detailNotizie dalla letteratura sicitaliana, ovvero siciliana e italiana (ed europea)
Curreri, Luciano ULg

Article for general public (2015)

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See detailAnalyse des propriétés anti-tumorales des exosomes endothéliaux dans le cancer du sein suite au transfert du microARN miR-503
Bovy, Nicolas ULg

Doctoral thesis (2015)

L’angiogenèse est un processus essentiel au développement tumoral ainsi qu’à la dissémination des métastases. De plus, il a été démontré ces dernières années que les miARN, des ARN non codant d'une ... [more ▼]

L’angiogenèse est un processus essentiel au développement tumoral ainsi qu’à la dissémination des métastases. De plus, il a été démontré ces dernières années que les miARN, des ARN non codant d'une vingtaine de nucléotides régulant l’expression des gènes au niveau post-transcriptionnel, jouent un rôle important dans divers processus tumoraux. Ils ont en outre été détectés dans plusieurs fluides biologiques, protégés de la dégradation dans des microvésicules, les exosomes. Cependant, à l’heure actuelle, aucune information n’est connue sur le rôle des exosomes endothéliaux et des miARN qu’ils contiennent sur la croissance tumorale. Au cours de ce travail, nous avons pour la première fois mis en évidence l’existence d’un transfert de miARN des cellules endothéliales vers les cellules tumorales par l’intermédiaire d’exosomes. Nous avons ensuite identifié un miARN, miR-503, dont l’export dans ces microvésicules est modifié en conditions tumorales. L’analyse de la fonction du miARN dans les cellules tumorales de cancer du sein montre qu’il possède des propriétés anti-tumorales en réduisant la prolifération et l’invasion. Nous avons également observé que le miR-503 d’origine endothéliale génère les mêmes effets. Pour expliquer ces résultats, deux cibles du miARN ont été identifiées, CCND2 et CCND3. De plus, l’inhibition de ces dernières conduit au même phénotype qu’une surexpression de miR-503. Nous avons ensuite voulu déterminer si le niveau plasmatique de ce miARN était modulé chez des patientes atteintes de cancer du sein. Nos analyses révèlent une augmentation du niveau sanguin de miR-503 à la suite d’un traitement par chimiothérapie néoadjuvante. Nous avons de plus observé que des cellules endothéliales soumises aux mêmes agents chimiothérapeutiques sécrètent activement du miR-503 dans leurs exosomes. Il semble également que le changement phénotypique induit par miR-503 sur les cellules tumorales modifie leur production en facteurs angiogènes ce qui mène, en retour, à une inhibition de l’angiogenèse. Ces résultats montrent que miR-503 est un miARN anti-tumoral sécrété dans les exosomes de cellules endothéliales. Celui-ci provoque l’inhibition de la prolifération et de l’invasion de cellules tumorales du cancer du sein en ciblant CCND2 et CCND3. Ce processus pourrait être complémentaire des effets directs générés par la chimiothérapie sur la tumeur et favoriser la réponse de l’hôte dans le traitement de la maladie. [less ▲]

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