Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailAssessing steady-state, multivariate experimental data using Gaussian Processes: the GPExp open-source library
Quoilin, Sylvain ULg; Schrouff, Jessica ULg

in Energies (2016), 9(6),

Experimental data are subject to different sources of disturbance and errors, whose importance should be assessed. The level of noise, the presence of outliers or a measure of the “explainability” of the ... [more ▼]

Experimental data are subject to different sources of disturbance and errors, whose importance should be assessed. The level of noise, the presence of outliers or a measure of the “explainability” of the key variables with respect to the externally-imposed operating condition are important indicators, but are not straightforward to obtain, especially if the data are sparse and multivariate. This paper proposes a methodology and a suite of tools implementing Gaussian processes for quality assessment of steady-state experimental data. The aim of the proposed tool is to: (1) provide a smooth (de-noised) multivariate operating map of the measured variable with respect to the inputs; (2) determine which inputs are relevant to predict a selected output; (3) provide a sensitivity analysis of the measured variables with respect to the inputs; (4) provide a measure of the accuracy (confidence intervals) for the prediction of the data; (5) detect the observations that are likely to be outliers. We show that Gaussian processes regression provides insightful numerical indicators for these purposes and that the obtained performance is higher or comparable to alternative modeling techniques. Finally, the datasets and tools developed in this work are provided within the GPExp open-source package. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailManagement of relapsed multiple myeloma: Recommendations of the international myeloma working group
Laubach, J.; Garderet, L.; Mahindra, A. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2016), 30(5), 1005-1017

The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level ... [more ▼]

The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM. [less ▲]

Detailed reference viewed: 42 (2 ULg)
Full Text
See detailMelodic perception
Larrouy, Pauline ULg

Scientific conference (2016, May 30)

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailEstetrol, a natural SERM exhibiting combined estrogenic and anti-estrogenic properties on mammary gland and breast cancer
Gallez, Anne ULg; Gérard, Céline ULg; BLACHER, Silvia ULg et al

Poster (2016, May 30)

The increased risk of breast cancer and thromboembolism in women who take hormone replacement therapy (HRT) is a major public health problem. The discovery of new drugs with better safety profile would ... [more ▼]

The increased risk of breast cancer and thromboembolism in women who take hormone replacement therapy (HRT) is a major public health problem. The discovery of new drugs with better safety profile would provide useful advances for patient care. Estetrol (E4) is a liver friendly promising candidate for HRT. In preclinical and/or clinical studies, E4 has been effective against the main symptoms of menopause from a starting dose of 0.3 mg/kg/day. The aim of this study was to define the impact of E4 on mammary gland and breast cancer development. Our preclinical data show that E4 is less efficient than estradiol (E2) to induce mammary gland growth. Treatment with several concentrations of E4 has shown that E4 did not increase tumor development, when it is used at 0.3 mg/kg/day. However, at 3 mg/kg/day, E4 increased tumor growth similarly to E2 (0.08 mg/kg/day). E4 presents also some anti-estrogenic effects on mammary gland and antitumor activity on breast cancer by decreasing the strong proliferative effect of E2. While ERα is the predominant receptor mediating its effects, the dual weak-estrogenic/anti-estrogenic feature of E4 results from differential signaling pathways activation. Both nuclear and rapid extra-nuclear signaling pathways are necessary for a complete estrogenic effect of E4. However, the antitumor action of E4 is not due to a capacity to antagonize E2-induced nuclear activity. In conclusion, our results support that E4, if it is used in strictly controlled clinical applications, could have no or only limited impact on breast and breast cancer. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailGC×GC-TOFMS for forensic blood VOC profiling
Dubois, Lena ULg; Perrault, Katelynn ULg; Stefanuto, Pierre-Hugues ULg et al

Poster (2016, May 30)

Detailed reference viewed: 7 (0 ULg)
Full Text
See detailNormer le passé : politique, droit et histoire
Grandjean, Geoffrey ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 18 (0 ULg)
See detailPsychopathologie légale : pour une complexité de la méthode
Englebert, Jérôme ULg

Scientific conference (2016, May 27)

Detailed reference viewed: 19 (0 ULg)
See detailL’initiative citoyenne européenne : porte ouverte des institutions européennes pour le citoyen?
Debras, François ULg; Nossent, Jérôme ULg

Conference (2016, May 27)

L’objectif de notre recherche n’est pas de nous concentrer sur la création ni sur le parcours d’une initiative citoyenne européenne mais bien d’étudier les conséquences politiques qui ont suivi ces ... [more ▼]

L’objectif de notre recherche n’est pas de nous concentrer sur la création ni sur le parcours d’une initiative citoyenne européenne mais bien d’étudier les conséquences politiques qui ont suivi ces initiatives. Pour ce faire, et compte tenu de la proximité temporelle du lancement du procédé, nous proposons de concentrer notre analyse sur les différentes suites qui furent données à la première des trois propositions ayant abouti, « Right2water ». Hormis la réponse obligatoire de la Commission, nous analysons l’impact et la mobilisation des enjeux de l’initiative par les institutions, les partis politiques, les députés européens et nationaux. L’initiative citoyenne européenne s’est-elle traduite en règlements ? En propositions ? A-t-elle été récupérée dans des programmes et discours politiques ou, à l’inverse, a-t-elle été écartée de l’agenda politique européen ? En d’autres mots, les propositions citoyennes ont-elles un poids sur la scène politique européenne ? L’initiative ouvre-t-elle la porte des institutions aux revendications des citoyens ? [less ▲]

Detailed reference viewed: 28 (0 ULg)
Full Text
See detailPathologies of the puerperium in the cow. How to define, diagnose, understand and treat.
Hanzen, Christian ULg

Learning material (2016)

The aim of this conference is to answer to the 8 following questions In which economical context are we working ? Is puerperium important for the reproductive performance of the cow ? How to define the ... [more ▼]

The aim of this conference is to answer to the 8 following questions In which economical context are we working ? Is puerperium important for the reproductive performance of the cow ? How to define the pathologies of the puerperium ? What’s the prevalence of these pathologies ? How to diagnose the pathologies of the puerperium ? When to detect these pathologies ? What kind of relations exist between these pathologies ? How to treat these pathologies ? [less ▲]

Detailed reference viewed: 110 (2 ULg)
Full Text
See detailDe l'activation des politiques d'emploi à l'agitation des chômeurs
Beuker, Laura ULg

Doctoral thesis (2016)

• Ce travail de thèse a pour objet la traduction et la mise en œuvre concrète du Plan d’accompagnement et de suivi des demandeurs d’emploi par les conseillers emploi (FOREm et Actiris) et par les ... [more ▼]

• Ce travail de thèse a pour objet la traduction et la mise en œuvre concrète du Plan d’accompagnement et de suivi des demandeurs d’emploi par les conseillers emploi (FOREm et Actiris) et par les facilitateurs (ONEm) en Belgique francophone. Ceux-ci sont effectivement situés en première ligne dans la mise en « actes » et en « mots » de cette mesure d’activation. Notre entrée dans les pratiques d’accompagnement et de suivi des demandeurs d’emploi repose sur une démarche empirique foncièrement qualitative. Le travail de terrain s’est déroulé entre janvier 2013 et février 2014. Il repose sur une immersion au sein de huit sites, et articule la réalisation d’entretiens semi-directifs, la récolte de documents internes et l’observation d’entretiens. Prenant appui sur les apports de l’Economie des conventions, de la Nouvelle sociologie économique et de la Sociologie des groupes professionnels, ce travail met en exergue l’idée selon laquelle plutôt que « d’activer » les demandeurs d’emploi, il est question « d’agiter » ces derniers… [less ▲]

Detailed reference viewed: 18 (3 ULg)