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The XMM-LSS catalogue: X-ray sources and associated multiwavelength data. Version II; ; et al in Monthly Notices of the Royal Astronomical Society (2012) We present the final release of the multi-wavelength XMM-LSS data set,covering the full survey area of 11.1 square degrees, with X-ray data processed with the latest XMM-LSS pipeline version. The present ... [more ▼] We present the final release of the multi-wavelength XMM-LSS data set,covering the full survey area of 11.1 square degrees, with X-ray data processed with the latest XMM-LSS pipeline version. The present publication supersedes the Pierre et al.(2007) catalogue pertaining to the initial 5 square degrees. We provide X-ray source lists in the customary energy bands (0.5-2 and 2-10 keV) for a total of 6721 objects in the deep full-exposure catalogue and 5572 in the 10ks-limited one, above a detection likelihood of 15 in at least one band. We also provide a multiwavelength catalogue, cross-correlating our list with IR, NIR, optical and UV catalogues. Customary data products (X-ray FITS images, CFHTLS and SWIRE thumbnail images) are made available together with our interactively queriable database in Milan, while a static snapshot of the catalogues will be supplied to CDS, as soon as final acceptance is completed. [less ▲] Detailed reference viewed: 19 (17 ULg) Fishermen's Knowledge in the Academic Salon - How Jean-André Peyssonnel's Studies of "Marine Products" at the Coasts of Barbary and Guadeloupe Influenced Debates on the True Nature of Coral in Eighteenth-Century EuropeVandersmissen, Jan ![]() Conference (2012, November 01) Detailed reference viewed: 28 (1 ULg) Developing national health sector monitoring and accountability platforms. The opportunity of IHP+ in Benin, Burkina Faso, Mali and SenegalPaul, Elisabeth ; ; et alConference (2012, November 01) There is now growing consensus about the importance of building and strengthening national monitoring platforms in order to facilitate the evaluation of large-scale health programmes and initiatives in ... [more ▼] There is now growing consensus about the importance of building and strengthening national monitoring platforms in order to facilitate the evaluation of large-scale health programmes and initiatives in low- and middle-income countries [see the paper published in 2010 in The Lancet by Victora et al.]. This is also crucial for improving accountability, which is defined by the United Nations' Commission on Information and Accountability for Women's and Children's Health as a cyclical process of monitoring, review, and (remedial) action. The International Health Partnership and related initiatives (IHP+), World Health Organization and other partners have recently developed guidelines to support country-led platforms for monitoring, evaluation and review of national health strategies. The national Compacts promoted in the framework of IHP+ offer an excellent opportunity to foster the development of such country-led platforms for information and accountability. Indeed, a Compact formalises the commitments of the recipient government and health sector partners to increase financing efforts in the health sector, to respect aid effectiveness principles and to support the national health policy and strategies in a common planning, coordination, and monitoring & evaluation framework. IHP+ is also closely connected to initiatives such as the Health Metrics Network that aims to improve the quality of health information in developing countries. We propose to analyse how the Ministries of Health in four Francophone Western African countries (Benin, Burkina Faso, Mali and Senegal) have seized the opportunity of IHP+ to strengthen their monitoring and accountability platforms, and assess what further actions could be taken in the future. We present a comparative analysis grid filled on the basis of the experience of the co-authors in supporting the process in the four countries. This composes the first step of an on-going research and experience sharing project supported by GRAP-PA Santé. [less ▲] Detailed reference viewed: 13 (2 ULg) Albedo and atmospheric constraints of dwarf planet Makemake from a stellar occultation; ; et al in Nature (2012), 491 Pluto and Eris are icy dwarf planets with nearly identical sizes, comparable densities and similar surface compositions as revealed by spectroscopic studies. Pluto possesses an atmosphere whereas Eris ... [more ▼] Pluto and Eris are icy dwarf planets with nearly identical sizes, comparable densities and similar surface compositions as revealed by spectroscopic studies. Pluto possesses an atmosphere whereas Eris does not; the difference probably arises from their differing distances from the Sun, and explains their different albedos. Makemake is another icy dwarf planet with a spectrum similar to Eris and Pluto, and is currently at a distance to the Sun intermediate between the two. Although Makemake's size (1,420+/-60km) and albedo are roughly known, there has been no constraint on its density and there were expectations that it could have a Pluto-like atmosphere. Here we report the results from a stellar occultation by Makemake on 2011 April 23. Our preferred solution that fits the occultation chords corresponds to a body with projected axes of 1,430+/-9km (1σ) and 1,502+/-45km, implying a V-band geometric albedo p[SUB]V[/SUB] = 0.77+/-0.03. This albedo is larger than that of Pluto, but smaller than that of Eris. The disappearances and reappearances of the star were abrupt, showing that Makemake has no global Pluto-like atmosphere at an upper limit of 4-12nanobar (1σ) for the surface pressure, although a localized atmosphere is possible. A density of 1.7+/-0.3gcm[SUP]-3[/SUP] is inferred from the data. [less ▲] Detailed reference viewed: 4 (1 ULg) Contrasting Two Ways of Making Psychology: Brentano and FreudGyemant, Maria ![]() Conference (2012, November 01) Brentano’s views on psychology influenced the way philosophy was made at the beginning of the 20th century. But did this influence spread as far as to give place to Freud’s revolutionary discovery of the ... [more ▼] Brentano’s views on psychology influenced the way philosophy was made at the beginning of the 20th century. But did this influence spread as far as to give place to Freud’s revolutionary discovery of the psychoanalytical unconscious? We know that Sigmund Freud attended enthusiastically Brentano’s lectures between 1874 and 1876. Yet, since Brentano’s name is never mentioned in Freud’s later, properly psychoanalytical writings, there is a very convincing argument for stating that Brentano had no lasting influence on Freud. Furthermore, Freud’s theory of the unconscious doesn’t seem to continue, but rather to oppose Brentano’s psychological views. Yet, as it was shown lately by a number of philosophers there are reasons to believe that Brentano had a profound influence on Freud. An attentive analysis of Freud’s vocabulary as well as his arguments against “philosophical” objections supports this point rather convincingly. However, Freud was not a philosopher and Brentano’s historical influence does not suffice to transform the Freudian unconscious in a philosophical concept. It is the purpose of this paper to sketch a way to make a philosophical use of Freud’s unconscious by reconstructing the dialogue between Brentano and Freud on a conceptual level. First, I will explain the differences between Brentano and Freud’s psychology. While Brentano and even the most original of his students thought the mind is entirely conscious, and they only called “unconscious” certain intermittences of this consciousness, Freud’s metapsychology rests on the supposition that the mind is primarily unconscious and it is consciousness that appears locally as a quality of certain mental events. In the second part of my paper I will show that this opposition is not as radical as it seems. Freud’s metapsychological supposition of an unconscious mind is not merely stated but proven by clinical facts. And these facts allow Freud to substitute a dynamic approach of the mental to a descriptive psychology of Brentanian inspiration: a mental state is only conscious because it becomes thus by passing from an unconscious to a conscious state. It is this change in the point of view that allows Freud to see mental events as processes rather than mere states. Thus, the results of Brentano’s descriptive psychology are not denied but rather completed by Freud’s dynamic theory of the unconscious. The purpose of this paper is thus to clarify not only Freud’s historical relation to Brentano, but also the relation of his metapsychology to Brentano’s descriptive psychology and to all psychology that takes Freud’s discovery of the unconscious seriously. Despite the explicit critique of the unconscious that we find in the Psychology from an Empirical Standpoint, I think that Freud never truly opposed Brentano. He rather took Brentano’s descriptive psychology a step further: he introduced a dynamic component to the analysis of the psyche that could throw light on the blind spots in Brentano’s psychology. [less ▲] Detailed reference viewed: 17 (0 ULg) Qualification d’un appareil d'éclairage décoratif soumis aux vibrations induites par un pont ferroviaire; ; Golinval, Jean-Claude ![]() Scientific conference (2012, November) Au même titre que la plupart des pièces mécaniques soumises aux vibrations, les appareils d'éclairage installés en extérieur sont amenés à satisfaire, en fonction de leurs conditions d’utilisation, aux ... [more ▼] Au même titre que la plupart des pièces mécaniques soumises aux vibrations, les appareils d'éclairage installés en extérieur sont amenés à satisfaire, en fonction de leurs conditions d’utilisation, aux exigences de procédures d'essais appliquées sur table vibrante. Celles-ci ont pour but de garantir l'intégrité structurelle du luminaire lorsque, une fois sur site, il est soumis aux effets du vent. Dans le cas des appareils d'éclairage décoratifs installés sur un pont de chemin de fer de structure métallique, le vent n'étant plus la source principale de vibrations en comparaison du trafic ferroviaire, on est dès lors confronté à une absence de toute indication appropriée décrivant l'essai à mener. Par conséquent, l'objectif de cette étude est d'élaborer une spécification d'essai de durée réduite, appliquée en laboratoire sur table vibrante, et représentative de l'environnement vibratoire réel de l'appareil à certifier. Sur base des essais réalisés en laboratoire, des prescriptions de montage et d'installation sont également formulées afin de garantir des conditions d’utilisation et d’essai identiques. [less ▲] Detailed reference viewed: 20 (1 ULg) Méthodologie d’excitation de modes à diamètres nodaux d’un anneau statorique de turboréacteurNyssen, Florence ; Golinval, Jean-Claude ; et alScientific conference (2012, November) Cette étude consiste à développer une approche expérimentale, permettant l’isolation de modes à diamètres nodaux spécifiques d’un étage statorique de compresseur basse pression, ayant pour objectif final ... [more ▼] Cette étude consiste à développer une approche expérimentale, permettant l’isolation de modes à diamètres nodaux spécifiques d’un étage statorique de compresseur basse pression, ayant pour objectif final la calibration de jauges de déformation. Plus spécifiquement, une étude portant sur le nombre minimal de sources d’excitation (shakers) et sur leur répartition circonférentielle optimale a été menée, l’objectif suivi étant d’isoler des modes à diamètres cibles dans des conditions de laboratoire. La première partie de l’étude consiste en une approche théorique, basée sur les concepts d’appropriation modale en régime forcé. La combinaison optimale des positions des différents points d’excitation est choisie de façon à maximiser une fonction objectif, définie comme le rapport entre l’énergie injectée dans le mode cible et la valeur maximale des énergies injectées dans les modes présentant une fréquence naturelle proche du mode d’intérêt. Dans la deuxième partie de l’étude, des simulations numériques sur un modèle éléments finis de la structure ont été menées sur base des résultats théoriques obtenus. Enfin, la troisième partie a permis de valider expérimentalement les prédictions numériques via des analyses d’influence du nombre d’excitateurs et de leur position sur l’amplitude de la réponse fréquentielle. [less ▲] Detailed reference viewed: 63 (17 ULg) Constant 2-labelling of weighted cycles; Vandomme, Elise ![]() Conference (2012, November) We introduce the concept of constant 2-labelling of a weighted graph and show how it can be used to obtain periodic sphere packing. Roughly speaking, a constant 2-labelling of a weighted graph is a 2 ... [more ▼] We introduce the concept of constant 2-labelling of a weighted graph and show how it can be used to obtain periodic sphere packing. Roughly speaking, a constant 2-labelling of a weighted graph is a 2-coloring (black and white) of its vertex set which preserves the sum of the weight of black vertices under some automorphisms. In this manuscript, we study this problem on weighted complete graphs and on weighted cycles. Our results on cycles allow us to determine (r,a,b)-codes in Z^2 whenever |a-b|>4 and r>1. [less ▲] Detailed reference viewed: 9 (1 ULg) Identification modale de systèmes variant dans le temps à partir de réponses simulées sur un exemple d'éoliennesBertha, Mathieu ; Golinval, Jean-Claude ![]() Poster (2012, November) Wind turbines are good examples of time-varying systems as their modal properties depend on their instantaneous configuration. To catch the variations of modal parameters in time-varying systems ... [more ▼] Wind turbines are good examples of time-varying systems as their modal properties depend on their instantaneous configuration. To catch the variations of modal parameters in time-varying systems, classical identification methods have to be adapted to the non-stationary nature of the recorded signals. In this paper, it is proposed to study the dynamic behavior of an offshore five-megawatt wind turbine. First, a numerical model of the wind turbine is created to serve as reference. Then, the time-varying behavior of the system is evaluated by simulating a large number of possible configurations. To this purpose, time responses are generated from the numerical model submitted to different environmental conditions. The wind is considered as the main non-measured external excitation force on the structure and the responses are recorded at several locations to simulate a real measurement process. Special care is brought to the accessibility of the measurement locations and to the limited number of available sensors in practice. Using these simulated measurements, output-only identification methods are used to extract varying dynamic properties of the structure. The final objective of this work is to pave the way to online condition monitoring of wind turbines. [less ▲] Detailed reference viewed: 39 (7 ULg) Détection d'endommagement et résonances locales sur composite CFRP par vibrothermographieDemy, Philippe ; Golinval, Jean-Claude ; Scientific conference (2012, November) La vibrothermographie est une technique de thermographie active capable de détecter des singularités de type délaminage ou décollement dans un matériau composite comme les laminés en fibres de carbone ... [more ▼] La vibrothermographie est une technique de thermographie active capable de détecter des singularités de type délaminage ou décollement dans un matériau composite comme les laminés en fibres de carbone très utilisés actuellement en construction aéronautique (CFRP). Les causes physiques du mécanisme d'échauffement interne, suite à l'interaction avec les ondes élastiques, peuvent être la friction, l'hystérésis viscoélastique ou encore la déformation plastique. La méthode est efficace également sur des géométries complexes et requiert uniquement que les deux faces internes du délaminage soient libres de vibrer. Cette étude consiste à déterminer la relation entre l'échauffement observé et la fréquence d'une excitation sinusoïdale entre 8 et 27 kHz. Il apparaît clairement des pics d'échauffement pour certaines fréquences particulières. La comparaison avec les fréquences de résonance locale du défaut modélisé par éléments finis montre des similitudes avec l'apparition de certains de ces pics. Une étude expérimentale visant à exploiter la présence de ceux-ci montre l'intérêt d'un test vibrothermographique de type balayage rapide (chirp), dans l'optique de mettre sur pied un test court et fiable pour le contrôle non destructif de matériaux composites. [less ▲] Detailed reference viewed: 74 (11 ULg) What is the best use of sugar crops? Environmental assessment of two applications : biofuels vs. bioproductsBelboom, Sandra ; Léonard, Angélique ![]() in [avniR] editions (Ed.) LCA Conference 2012 - Proceedings of the 2nd international conference on life cycle approaches (2012, November) Agricultural crops became through years a possibility to increase European energy independence. Brazil has taken this opportunity since the seventies by using sugar cane bioethanol as vehicle fuel. The ... [more ▼] Agricultural crops became through years a possibility to increase European energy independence. Brazil has taken this opportunity since the seventies by using sugar cane bioethanol as vehicle fuel. The development of biofuels production is more recent in Europe. Due to temperate climates, bioethanol production is mostly based on wheat and sugar beet, this latter being considered as the ‘equivalent’ sugar crop to sugar cane for Europe. Biofuel is the most common application of bioethanol but its transformation into bioethylene through a dehydration step can be an alternative as already found in Brazil. This paper will consider both potential uses and compare them using Life Cycle Assessment methodology. Common boundaries of the systems comprise the cultivation step for both crops, i.e. sugar cane and sugar beet, with all associated energetic and fertilizer consumptions, the transportation step from field to the industrial plant, the sugar crops transformation into hydrate bioethanol and the by-products valorisation. For the biofuel scenario, a dehydration step using molecular sieve is added to get anhydrous bioethanol. For the bioethylene scenario, an industrial dehydration step is added. Direct comparison between both scenarios is not possible due to different products uses. The comparison was then performed for both scenarios between the bio-based product and its fossil equivalent. ReCiPe 2008 method was used to get the environmental impacts. As expected, the impact of bio-based products in climate change and fossil fuel depletion categories decreases compared to the fossil counterparts. For other categories, difference is less significant and results are often better for fossil products. Land use change category was implemented to assess its importance. Depending on assumptions, the greenhouse gas emissions from crop implementation on a natural land can counteract the previous mentioned benefits. This study shows the importance of assumptions, especially in the agricultural field, on the obtained results. [less ▲] Detailed reference viewed: 35 (7 ULg) European Initiative for the Exchange of Young Officers inspired by ErasmusPaile, Sylvain ![]() in Weisserth, Hans-Bernhard; Rehrl, Jochen (Eds.) CSDP Handbook - The Common Security and Defence Policy of the European Union (2012) Detailed reference viewed: 15 (0 ULg) Point actuel sur la signification des ratios agonistes / antagonistes au membre inférieurCroisier, Jean-Louis ; Delvaux, François ; Kaux, Jean-François et alin Abstract book des XIVèmes Rencontres isocinétiques MEDIMEX / ROTHSCHILD (2012, November) Detailed reference viewed: 28 (3 ULg) Economic impact of RVF outbreaksAntoine-Moussiaux, Nicolas ; ; et alConference (2012, November) Dwarfing the direct losses due to ruminant abortions and flock mortality, the main economic impact of RVF is systemic and ensues from the trade restrictions aimed at its containment. Indeed, past ... [more ▼] Dwarfing the direct losses due to ruminant abortions and flock mortality, the main economic impact of RVF is systemic and ensues from the trade restrictions aimed at its containment. Indeed, past outbreaks of RVF in East Africa and Middle East came as disturbing events in a commercial context of high specialization in trade of small ruminants and interdependence between East-African exporters and the Middle-Eastern importing countries. The two successive bans imposed by Middle-Eastern countries on livestock products coming from the Horn of Africa in 1998-1999 and 2000-2002 highlighted this interdependence. Both bans caused an abrupt stop in exportations from IGAD countries. Nevertheless, the impact of the outbreaks motivating these bans differed due to their unique timing with regard to the Muslim celebrations that trigger the main flow of livestock from the Horn of Africa to Mecca. Hence, in 2000, the worst impact was observed on pastoralist households because the ban was imposed in September, prior to the Haj festival, when the main seasonal export flow had not been realized yet. Regarding the 1997 outbreak, the ban was implemented only in February 1998, after the main trade flow had occurred. The impacts of the bans on Somalia were particularly severe, due to the high specialization of the concerned region in an export-oriented livestock sector, benefitting from a niche market organized around the above-mentioned religious festivals and Arab consumers preferences. The country was all the more affected, as they own two main ports involved in this trade, i.e. Berbera (Somaliland) and Bossaso (Puntland). Prior to the bans, the size of the export market from Somalia to Saudi Arabia and the United Arab Emirates was estimated around US$600 million, with Saudi Arabia representing 66% of the total. The bans led the Somali livestock market to collapse. Losses for the livestock industry were estimated at US$109 million and US$326 million, for the first and second ban respectively. The government also directly incurred an important loss around US$45 million from foregone export taxes and docking fees. In the same time, livestock exporters lost a net cumulative profit of US$330 million, whereas producers estimated their annual losses at over US$8 million. Hence, the successive RVF-related trade bans impacted the employment rate, the public treasury, the exchange rate of national currency and thus, the price of imported goods, inducing a general inflationary pressure and important socio-economic upheavals. More generally, the livestock market in the whole East Africa was affected, due to the fall in prices caused by the loss of outlets for livestock. Using market equilibrium models taking these shocks into account, the impact of the trade bans on the Somali region of Ethiopia were estimated at a 36% fall of the GDP. Other impacts originated in the closure of markets inside East Africa, being part of national control strategies. In Kenya, e.g., the closure of the Garissa Market, which is a major outlet for Somali and Ethiopian livestock, resulted in a more than 25% decrease in the price of cattle, inducing a total loss of US$10 million for the value chain. The emergency destocking response of distressed households also participated to the fall in prices and worsening of terms of trade. Together with flock mortality and abortion, destocking moreover affects the herds’ dynamics on the long run and the commercial potential of households. These mechanisms show greater impact on smallholders, due to threshold effects in livestock capitalisation and the loss in risk management ability in such variable environmental conditions. In the Middle East too, the bans showed drastic economic impacts. In Yemen, e.g., the bans caused a loss of US$15 million from foregone custom taxes and US$27 million profit losses for traders. The two bans, combined with the prolonged ban maintained till 2009 by Saudi Arabia on Somalia, contributed to a restructuration of trade within and between the two regions. Indeed, trade actors soon reorganized their activity, as highlighted through official figures, notwithstanding the importance of informal trade. Hence, Yemen and the United Arab Emirates appeared as major alternative entry points on Arab Peninsula for Somali livestock. The latter could also transit through Djibouti or Sudan to reach Saudi Arabia. Benefitting from the prolonged bans on Somalia, the port of Djibouti emerged as a major player in the region between 2006 and 2009, thanks to massive investment in port infrastructures and agreements with Saudi importers. Therefore the private sector played a considerable role in adapting to new risks. The Djibouti port diverted much of the livestock trade previously handled at the Berbera and Bossaso ports. On this occasion, as it has been the case in Somalia after ban lifting in 2009, the Middle East has been a source of investment for the Horn of Africa for biosecurity infrastructure. Finally, the second ban led to the emergence of Australia as a major livestock supplier for Saudi Arabia from 2000 till now, and to a certain a point Australia has been a country of major Saudi investments which is seen as another way of adapting for some major value chain agents. In the two last decades, the intraregional livestock trade grew rapidly in East Africa, spurred by the urban demand. Most of this trade is informal, thus lacking official figures. It nevertheless shows a great importance regarding poverty alleviation aspects, the small to medium actors being the main operators of this trade. In recent years, a considerable growth in recorded intraregional trade is noticed, mainly due to a growth of recorded exports from Ethiopia to neighboring countries, as a result of a policy aiming at the facilitation of registration procedures through the CAC/AP-system. As a conclusion, livestock export to Middle East and the growing intraregional East-African livestock trade are both threatened by RVF-linked bans due to loss of outlets and price volatility. Thus, stability of the livestock sector being crucial to human and economic development in the region, a high priority must be given to RVF prevention and control, as supported by figures of impact of past outbreaks. [less ▲] Detailed reference viewed: 14 (1 ULg) Moisture equilibrium in straw bale walls; Louis, Arnaud ; et alConference (2012, November) Straw bales technology for buildings is developing in Belgium as in many other countries. The market is growing but significant uncertainties are left concerning how to model its dynamical hygrothermal ... [more ▼] Straw bales technology for buildings is developing in Belgium as in many other countries. The market is growing but significant uncertainties are left concerning how to model its dynamical hygrothermal performances and its long term behaviour. The present paper presents the preliminary analysis conducted on material parameters and component’s response to dynamic heat and moisture solicitations. The simulations use WUFI Pro software based on material parameters form literature and both reference climate files for Belgium and theoretical climates to analyse the interactions between straw bale walls and finishing materials and their influence on component performances and durability. A specific prefabricated wall element sold on Belgian market is detailed and introduced in simulations. The influence on comfort feelings and indoor air quality are discussed with a focus on component´s thermal inertia and moisture regulation capacity. The paper concludes with recommendations on wall composition to help straw bale technologies to develop in building market of Belgium and other countries. [less ▲] Detailed reference viewed: 27 (5 ULg) The instability strip of ZZ Ceti white dwarfs and its extension to extremely low mass pulsatorsVan Grootel, Valérie ![]() Conference (2012, November) Detailed reference viewed: 13 (2 ULg) Cahiers d'études du renseignement vol.2; ; et al in Cahiers d'études du renseignement (2012), 2 Périodique réalisé par le Belgian Intelligence studies center Detailed reference viewed: 45 (30 ULg) Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 β-lactamases.; ; et al in Antimicrobial Agents and Chemotherapy (2012), 56(11) GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and ... [more ▼] GES-1 is a class A extended-spectrum β-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, differing from each other by 1 to 3 amino acid substitutions that affect substrate specificity. GES-11 possesses a Gly243Ala substitution which seems to confer to this variant an increased activity against aztreonam and ceftazidime. GES-12 differs from GES-11 by a single Thr237Ala substitution, while GES-14 differs from GES-11 by the Gly170Ser mutation, which is known to confer increased carbapenemase activity. GES-11 and GES-12 were kinetically characterized and compared to GES-1 and GES-14. Purified GES-11 and GES-12 showed strong activities against most tested β-lactams, with the exception of temocillin, cefoxitin, and carbapenems. Both variants showed a significantly increased rate of hydrolysis of cefotaxime, ceftazidime, and aztreonam. On the other hand, GES-11 and GES-12 (and GES-14) variants all containing Ala243 exhibited increased susceptibility to classical inhibitors. The crystallographic structures of the GES-11 and GES-14 β-lactamases were solved. The overall structures of GES-11 and GES-14 are similar to that of GES-1. The Gly243Ala substitution caused only subtle local rearrangements, notably in the typical carbapenemase disulfide bond. The active sites of GES-14 and GES-11 are very similar, with the Gly170Ser substitution leading only to the formation of additional hydrogen bonds of the Ser residue with hydrolytic water and the Glu166 residue. [less ▲] Detailed reference viewed: 2 (1 ULg) Reply to the EditorSEGHAYE, Marie-Christine ![]() in Annals of Thoracic Surgery (2012), 94(5), 1787 Detailed reference viewed: 2 (1 ULg) Thermal effect characterization in the excavation damaged zone around tunnels for the nuclear waste disposal in argillaceous rocks; ; Collin, Frédéric et alConference (2012, November) Detailed reference viewed: 17 (0 ULg) |
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