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See detailLes peptides natriurétiques: le point de vue du biologiste
LE GOFF, Caroline ULg

Conference (2015, February 26)

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See detailPotential Proteomic Biomarkers Associated with Mucosal Healing and Relapse Prediction after IFX Withdrawals in Crohn’s Disease
MEUWIS, Marie-Alice ULg; QUESADA CALVO, Florence ULg; Baiwir, Dominique ULg et al

in Acta gastroenterologica (2015, February 26)

Introduction and objectives: In Crohn's disease (CD), there is a discrepancy between clinical activity of the disease (symptoms) and intestinal healing. However absence of tissue healing is associated ... [more ▼]

Introduction and objectives: In Crohn's disease (CD), there is a discrepancy between clinical activity of the disease (symptoms) and intestinal healing. However absence of tissue healing is associated with the risk of relapse and tissue damage progression. Endoscopy is costly and invasive. Hence biomarkers correlating with intestinal healing could improve disease management and potentially decrease the number of endoscopy when patients are in clinical remission. Aim: We aimed to identify potential biomarkers associated to CD mucosal healing and relapse after IFX withdrawals by a shotgun label-free proteomic study. Methods: We used the STORI1 clinical trial cohort (n=103) aiming at identifying markers associated to relapse prediction after Infliximab treatment withdrawals. We used serum samples of patients in clinical remission (at base line). We grouped these according to the degree of intestinal healing seen at endoscopy or according to relapse occurrence during the 28 month follow-up and composed pooled samples. We performed depletion of the 20 most abundant plasma proteins on each serum pools and ran a proteomic label-free differential analysis using 2D-nanoUPLC-MSE HDMS Synapt G2 for data acquisition. We performed different statistical analysis. Moreover, a Gene Ontology annotation was also performed for the potential biomarkers highlighted. Results and Discussion: We identified analysing these depleted serum pools 430 different proteins and 188 proteins common to all samples. Among these, 40 were found with a significant differential abundance in the groups compared. We selected some among the most significant one (ratio>1.3) or being by nature consistent with the context of this study (sample origin and clinical question addressed). For example, the C-reactive protein (CRP) was found with a significant Ratio of 2 between Relapsers and Non Relapsers. The other potential biomarkers associated to mucosal healing or to relapse prediction, were selected for further validation by Western Blot analysis (WB), routine laboratory tests and also by a Mass Spectrometry based technology: multiplexed selected reaction monitoring (SRM). Multiplexed SRM will enable quantitative analysis of these candidates in each individual patient as well as WB tests. Conclusions: This research strategy and the validation results on potential biomarkers associated to mucosal healing or relapse after treatment cessation in this cohort of CD patients, as well as tests done on other CD patients, might provide new opportunities for patient follow-up test developments. The next step is to perform SRM validation on the STORI cohort and design signatures using these potential biomarkers SRM data for prognosis power evaluation. 1. Louis E, Mary JY, Vernier-Massouille G, et al. Maintenance of remission among patients with Crohn's disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology 2012;142:63-70 e5; quiz e31. [less ▲]

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See detailTeaching and Training TA
Delvenne, Pierre ULg; Rosskamp, Benedikt ULg; Bütschi, Danielle et al

Poster (2015, February 26)

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See detailTechnology Assessment in East Asia: Experiences and New Approaches
Moniz, Antonio; Yoshizawa, Go; Van Oudheusden, Michiel ULg

Conference (2015, February 25)

Integrating social and ethical concerns in innovation practice is a well-documented and debated issue in the United States and in Europe (namely through the EU-wide PACITA project). Related developments ... [more ▼]

Integrating social and ethical concerns in innovation practice is a well-documented and debated issue in the United States and in Europe (namely through the EU-wide PACITA project). Related developments in other parts of the world are less discernible – at least to Westerns. Yet, as witnessed by the emergence of technology assessment (TA) in countries like Japan, TA and TA-like activities have a unique and long history and continue to play a role in contemporary STI processes (e.g. in the area of citizen engagement with nanotechnologies, or energy policy). Taking these observations as its entry point, this panel asks how STI governance is locally enacted in Asian knowledge-driven economies. Like their Western counterparts, nations like China, Indonesia, Japan, the Republic of Korea, Singapore, Taiwan, etc., have undergone, and continue to undergo, rapid science- and technology-driven industrialization. In these processes, TA and TA-like activities develop with STI policies and programs and typically do so in nation- and region-specific ways. To render these processes, policies, and programs visible, and understand their implications for STI governance, this panel will discuss contributions that: • Describe and conceptualize how TA and TA-like activities have emerged in Asian KBEs, and in what particular forms (e.g. academic and parliamentary TA programs, linked to certain technologies and/or actors, which methods are used and why, etc.). • Reflect how these activities has evolved with, sustained, and/or countered, STI policies on the regional, national, and international level. • Compare and contrast how TA is, or is not, institutionalized in Asian countries and regions, e.g. through initiatives to initiate or abolish various TA forms, such as health TA, early-warning TA, and parliamentary TA; and/or point to prospects for TA capacity building. • Situate the above processes within a broader theory of, and movement towards, new STI governance frameworks, such as anticipatory governance, responsible innovation, public engagement, and/or others. By placing the development in historical, sociological, and comparative perspective, the panel seeks to open a space for critical reflection on the potential, problems, and limitations of initiating TA in Asia and draw connections to STI governance processes in other KBEs across the globe. [less ▲]

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See detailGranular transport in driven granular gas
Noirhomme, Martial ULg; Opsomer, Eric ULg; Ludewig, François ULg et al

in European Physical Journal E -- Soft Matter (2015), 38

We numerically and theoretically investigate the behavior of a granular gas driven by asymmetric plates. The injection of energy in the dissipative system differs from one side to the opposite one. We ... [more ▼]

We numerically and theoretically investigate the behavior of a granular gas driven by asymmetric plates. The injection of energy in the dissipative system differs from one side to the opposite one. We prove that the dynamical clustering which is expected for such a system is affected by the asymmetry. As a consequence, the cluster position can be fully controlled. This property could lead to various applications in the handling of granular materials in low-gravity environment. Moreover, the dynamical cluster is characterized by natural oscillations which are also captured by a model. These oscillations are mainly related to the cluster size, thus providing an original way to probe the clustering behavior. [less ▲]

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See detailLivre Blanc Céréales
Watillon, Bernard ULg; Bodson, Bernard ULg

Book published by Gembloux Agro-Bio Tech - Edition février 2015 (2015)

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See detail2. Implantation des cultures
Eylenbosch, Damien ULg; Meza Morales, Walter ULg; Monfort, Bruno et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail10. Perspectives - 2. Utilisation de l'imagerie hyperspectrale proche infrarouge pour estimer la biomasse racinaire d'une culture de froment
Eylenbosch, Damien ULg; Fernandez Pierna, Juan Antonio; Baeten, Vincent et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail4. La fumure azotée
Meza Morales, Walter ULg; Monfort, Bruno; Dumont, Benjamin ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail5. Régulateurs de croissance
Henriet, François; Monfort, Bruno; Meza Morales, Walter ULg

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail6. Lutte intégrée contre les maladies
Bataille, Charlotte; Duvivier, Maxime; Eylenbosch, Damien ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detailLead concentrations and isotope ratios in speleothems as proxies for atmospheric metal pollution since the Industrial Revolution
Allan, Mohammed ULg; Fagel, Nathalie ULg; Van Rampelbergh, maite et al

in Chemical Geology (2015)

Lead concentrations and isotope ratios from two speleothems from the Han-sur-Lesse cave in southern Belgium were measured in order to study the ability of speleothems to act as archives of atmospheric ... [more ▼]

Lead concentrations and isotope ratios from two speleothems from the Han-sur-Lesse cave in southern Belgium were measured in order to study the ability of speleothems to act as archives of atmospheric pollution. To address this aim we analyzed trace elemental Al and Pb compositions by LA-ICP-MS and ICP-MS as well as Pb isotopes by MC-ICP-MS. The results help to identify three intervals characterized by particularly high enrichment of Pb: from 1880 to 1905 AD, from 1945 to 1965 AD, and from 1975 to 1990 AD. The speleothem record shows similar changes as the known historical atmospheric pollution level in Belgium. Lead isotope ratios discriminate between Pb sources and confirm that coal and gasoline combustion, combined with regional metallurgical activities, were the predominant Pb pollution sources in the stalagmites during the last 250 years. This study opens possibilities to determine anthropogenic versus natural metal sources in well-dated speleothem archives. [less ▲]

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See detailRetirement age and the age of onset of Alzheimer’s disease: Results from the ICTUS study
Grotz, Catherine ULg; Letenneur, Luc; Bonsang, Eric ULg et al

in PLoS ONE (2015)

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See detailPropagation of uncertainties using probabilistic multi-scale models
Lucas, Vincent ULg; Wu, Ling ULg; Paquay, Stéphane et al

Conference (2015, February 25)

When applying a multiscale approach, the material behavior at the macro-scale can be obtained from an homogenization scheme. To this end, at each integration-point of the macro-structure, the macrostress ... [more ▼]

When applying a multiscale approach, the material behavior at the macro-scale can be obtained from an homogenization scheme. To this end, at each integration-point of the macro-structure, the macrostress tensor is related to the macro-strain tensor through the resolution of a micro-scale boundary value problem. At the micro-level, the macro-point is viewed as the center of a Representative Volume Element (RVE). However, to be representative, the micro-volume-element should have a size much bigger than the micro-structure size. When considering structures of reduced sizes, such as micro-electro-mechanical systems (MEMS), as the size of the devices is only one or two orders of magnitude higher than the size of their microstructure, i.e. their grain size, the structural properties exhibit a scatter at the macro-scale. The representativity of the micro-scale volume element is lost and Statistical Volume Elements (SVE) should be considered in order to account for the micro-structural uncertainties. These uncertainties should then be propagated to the macro-scale in order to predict the device properties in a probabilistic way. In this work we propose a non-deterministic multi-scale approach [1] for poly-silicon MEMS resonators. A set of SVEs is first generated under the form of Voronoi tessellations with a random orientation assigned for each silicon grain of each SVE. The resolution of each micro-scale boundary problem is performed by recourse to the computational homogenization framework, e.g. [2], leading to meso-scale material properties under the form of a linear material tensor for each SVE. Applying a Monte-Carlo procedure allows a distribution of this material tensor to be determined at the meso-scale. The correlation between the meso-scale material tensors of two SVEs separated by a given distance can also be evaluated. A generator of the meso-scale material tensor is then implemented using the spectral method [3]. The generator [1] accounts for a lower bound [4] of the meso-scale material tensor in order to ensure the existence of the second-order moment of the Frobenius norm of the tensor inverse [5]. A macro-scale finite element model of the beam resonator can now be achieved using regular finite-element, i.e. not conforming with the grains, and the material tensor at each Gauss point is obtained using the meso-scale generator, which accounts for the spatial correlation. A Monte-Carlo method is then used at the macro-scale to predict the probabilistic behavior of the MEMS resonator. As an example the beam resonator illustrated in Fig. 1(a) is made of poly-silicon, and each grain has a random orientation. Solving the problem with a full direct numerical simulation combined to a Monte-Carlo method allows the probability density function to be computed as illustrated in Fig. 1(b). However this methodology is computationally expensive due to the number of degrees of freedom required to study one sample. The proposed non-deterministic multi-scale strategy allows reducing this computational cost as the Monte-Carlo processes are applied on much smaller finite-element models. The method can also be applied in the context of fracture of thin poly-silicon film [6]. In this case, a set of meso-scopic cohesive laws can be obtained at the meso-scale from the resolution of different SVEs. The meso-scopic cohesive laws are obtained for each RVE from the finite element resolution of the Voronoi tessellations using the method proposed in [7]. The resulting statistical values for the critical energy release rate and for the critical strength can then be used for macro-scale simulations. [less ▲]

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See detail7. Lutte intégrée contre les ravageurs - 2.1 Suivi des populations de cécidomyie équestre, Haplodiplosis marginata, grâce au développement d'un piège à phéromone
Censier, Florence ULg; Fischer, Christophe ULg; Chavalle, Sandrine et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detailProtection of Antarctic microbial communities–‘out of sight, out of mind’
Hughes, Kevin; Cowan, Don; Wilmotte, Annick ULg

in Frontiers in Microbiology (2015), 6(151), 1-6

RecentadvancesinmolecularbiologytechniqueshaveshownthepresenceofdiversemicrobialcommunitiesandendemicspeciesinAntarctica.Endemicmicrobesmaybeapotentialsourceofnovelbiotechnologicallyimportantcompounds ... [more ▼]

RecentadvancesinmolecularbiologytechniqueshaveshownthepresenceofdiversemicrobialcommunitiesandendemicspeciesinAntarctica.Endemicmicrobesmaybeapotentialsourceofnovelbiotechnologicallyimportantcompounds,including,forexample,newantibiotics.Thus,thescientificandbiotechnologicalvalueofAntarcticterrestrialmicrobialhabitatscanbecompromisedbyhumanvisitationtoagreaterextentthanpreviouslyrealized.Theever-increasinghumanfootprintinAntarcticamakesconsiderationofthistopicmorepressing,asthenumberoflocationsknowntobepristinehabitats,whereincreasinglysophisticatedcutting-edgeresearchtechniquesmaybeusedtotheirfullpotential,declines.ExaminationoftheProtectedAreassystemoftheAntarcticTreatyshowsthatmicrobialhabitatsaregenerallypoorlyprotected.NoothercontinentonEarthisdominatedtothesamedegreebymicrobialspecies,andrealopportunitiesexisttodevelopnewwaysofconceptualizingandimplementingconservationofmicrobialbiogeographyonacontinentalscale.Herewehighlightpotentialthreatsbothtotheconservationofterrestrialmicrobialecosystems,andtofuturescientificresearchrequiringtheirstudy. [less ▲]

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See detail10. Perspectives - 1. La Lutte contre les pucerons grâce aux odeurs: développement d'une formulation phéromonale
Fassotte, Bérénice ULg; Vandereycken, Axel ULg; Chevalier Mendes Lopes, Thomas ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detailImpact de la dynamique foncière dans la lutte contre l’insécurité foncière et la pauvreté des femmes dans la région de Tahoua au Niger
Moussa dit Kalamou, Mahamadou ULg

Doctoral thesis (2015)

In Niger Republic land issue is a concern to all parties acting in the rural area. The drought cycles of the last decades and the rapid increase of the population that doubles every ten years are ... [more ▼]

In Niger Republic land issue is a concern to all parties acting in the rural area. The drought cycles of the last decades and the rapid increase of the population that doubles every ten years are determinant factors of degradation of the agricultural land of culture with as consequence the land and food insecurity of the households in particular in the region of Tahoua. Despite efforts by the government and its partners through the village land management programs and natural regeneration, land access difficulties persist particularly for women households. The objective being to assess and analyze the impact of land dynamics induced by the recovery of land in order to find some solutions to the problems of land insecurity and access and control of natural resources by households, a survey was conducted in two phases. The first in 2010 for a sample of 420 households in twenty villages selected through a stratified sampling. The second in 2012 for a sample of 84 households with 42 female heads of household from the first sample being associated with a group of 42 male heads of households for a specific gender analysis. It appears from this study that men households have an average land area about twice as large as that of female households .It was also found that the land is usually concentrated in the hands of older householders over 60 years. It is noticed that the inheritance is also one of the most dominant modes of access to land. The fragmentation and the expansion of croplands favor the emergence of fields beyond the northern boundary of crops dedicated to breeding. Finally, the last three years, agricultural production has generally fallen. The results of the analysis also show that unlike men, women household heads have less inputs, on the one hand, and little income, on the other hand. These female households derive their main income from the sale of animal products. This proves that women are the poorest households with limited access to natural resources. To fight against tenure insecurity and poverty of households recommendations and perspectives have been identified for the establishment of good governance of land resources, intensification of anti-erosion works by households with substantial resources and initiation of other additional research for sustainable development of the region. [less ▲]

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