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See detailGamma radiation induced modifications of tapioca starch
Atrous, Hager; Benbettaïeb, Nasreddine; Hosni, Faouzi et al

in Asian Academic Research Journal of Multidisciplinary (2016), 3(3), 187-220

The effect of gamma radiation (3, 5, 10, 20, 35 and 50 kGy) on the morphological, structural, physicochemical, pasting and thermal properties of tapioca starch was studied. Microphotographs of scanning ... [more ▼]

The effect of gamma radiation (3, 5, 10, 20, 35 and 50 kGy) on the morphological, structural, physicochemical, pasting and thermal properties of tapioca starch was studied. Microphotographs of scanning electron microscopy and polarized light microscopy revealed the absence of morphological changes induced by gamma radiation. The X-ray diffraction spectra showed that irradiation treatment did not influence the shape and intensity of X-ray diffraction peaks. The presence of free radicals in the irradiated tapioca starch was confirmed by electron spin resonance spectrometry. Fourier transform infrared spectroscopy showed that the irradiated starch displayed a significant decrease in the intensity of the O–H and C–H stretches, bending modes of water and glycosidic linkages. Irradiation improved the water solubility index of starch granules and depressed the apparent amylose content. An increase in the swelling power was observed after irradiation treatment until 20 kGy, followed by a decrease at higher doses. Brabender viscoamylograph test showed that the maximal consistency of the starch paste decreased significantly with increasing irradiation dose. There was no significant difference in the gelatinization temperatures, as well as the corresponding transition enthalpies among native and irradiated tapioca starch samples, as shown in the differential scanning calorimetry thermograms. [less ▲]

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See detailInhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolismdependent manner
Bunik, Victoria; Mkrtchyan, Garait; Grabarska, Aneta et al

in Oncotarget (2016), 7(26400), 26421

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific ... [more ▼]

2-Oxoglutarate dehydrogenase (OGDH) of the tricarboxylic acid (TCA) cycle is often implied to be inactive in cancer, but this was not experimentally tested. We addressed the question through specific inhibition of OGDH by succinyl phosphonate (SP). SP action on different cancer cells was investigated using indicators of cellular viability and reactive oxygen species (ROS), metabolic profiling and transcriptomics. Relative sensitivity of various cancer cells to SP changed with increasing SP exposure and could differ in the ATP- and NAD(P)H-based assays. Glioblastoma responses to SP revealed metabolic sub-types increasing or decreasing cellular ATP/NAD(P)H ratio under OGDH inhibition. Cancer cell homeostasis was perturbed also when viability indicators were SPresistant, e.g. in U87 and N2A cells. The transcriptomics database analysis showed that the SP-sensitive cells, such as A549 and T98G, exhibit the lowest expression of OGDH compared to other TCA cycle enzymes, associated with higher expression of affiliated pathways utilizing 2-oxoglutarate. Metabolic profiling confirmed the dependence of cellular SP reactivity on cell-specific expression of the pathways. Thus, oxidative decarboxylation of 2-oxoglutarate is significant for the interdependent homeostasis of NAD(P)H, ATP, ROS and key metabolites in various cancer cells. Assessment of cellspecific responses to OGDH inhibition is of diagnostic value for anticancer strategies. [less ▲]

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See detailGAY ADOPTIVE FAMILIES: WHAT IS THE IMPACT OF THE LEGAL STATUS?A COMPARISON BETWEEN BELGIUM AND FRANCE
Messina, Roberta ULg; D'Amore, Salvatore ULg

Scientific conference (2016, March)

Despite the numerous studies on gay families, the current literature that has focused specifically on gay adoptive parent families remains rather limited. In Europe the laws on adoption by same-sex ... [more ▼]

Despite the numerous studies on gay families, the current literature that has focused specifically on gay adoptive parent families remains rather limited. In Europe the laws on adoption by same-sex couples change radically from a country to another one. That’s why the experience of these families can be very different according to their country of residence. What are the main stressors that gay adoptive parents have to face? What are the strategies of coping built by these families? This exploratory research examines the stressors and the coping strategies of 18 gay adoptive families (12 from France, 6 from Belgium) with children aged from 3 to 10. Participants were recruited via adoption agencies. Belgian parents adopted their children through national full joint adoption. Conversely, French participants became parents through international adoption as “single parents” (even if they were in a relationship, just one of the partners was legally involved in the adoption). Semi-structured interviews were conducted with parents. Using grounded theory methods, analyses revealed that parents face different stressors such as the homophobia by social workers, the lack of support by families of origin and social context, the afraid of not being considered parents "like the others" and the worry about discrimination of their children. In the French sample, these stressors were increased by a long procedure in which the “legal parent” had to lie about his sexual orientation and the other parent had to hide himself in order to assure the success of the adoption procedure. This can have a negative impact on the couple's relationship, on the feeling of legitimacy about parental role, in the relationship with the child and with the extended family. To cope with these stressors, many adaptive strategies have proved to be useful: don’t hide the sexual orientation to the children, join adoption associations, share experiences with other gay parents, take care of the couple relationship, being in touch with accepting people and protect themselves from discriminatory people. This comparison between Belgian and French families’ experience allows us to understand the impact of the legal status on the life of gay parents and their children. [less ▲]

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See detailLes deux laïcités
Jacquemain, Marc ULg

in Garcet, Marc; Della Piazza, Serge (Eds.) Entre physis et nomos. Pour vivre ensemble, nouvelles pratiques (2016)

Le texte montre comment, selon la manière dont on la conçoit, la laÏcité peut favoriser ou au contraire fragiliser les libertés publiques. Il examine notamment la distinction entre public et privé et le ... [more ▼]

Le texte montre comment, selon la manière dont on la conçoit, la laÏcité peut favoriser ou au contraire fragiliser les libertés publiques. Il examine notamment la distinction entre public et privé et le statut de neutralité des fonctionnaires. [less ▲]

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See detailLa mise en état et les conclusions
Stassin, Maxime ULg

in Boularbah, Hakim; van Drooghenbroeck, Jean-François (Eds.) Pot-pourri I et autres actualités en droit judiciaire (2016)

Actualités en matières de mise en état et de rédaction des conclusions suite à la loi du 19 octobre 2015, dite "Pot-pourri I".

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See detailInfection expérimentale de porcs, par voie intraveineuse ou orale, avec une souche du virus de l’hépatite E (HEV) de sanglier, une souche de HEV porcine et une souche de HEV de sanglier préalablement passée en modèle porcin
Thiry, Damien ULg; Rose, Nicolas; Mauroy, Axel ULg et al

Poster (2016, March)

La transmission zoonotique du HEV est particulièrement mise en cause dans les pays développés dans lesquels la transmission via les eaux usées est beaucoup moins fréquente que dans les pays en voie de ... [more ▼]

La transmission zoonotique du HEV est particulièrement mise en cause dans les pays développés dans lesquels la transmission via les eaux usées est beaucoup moins fréquente que dans les pays en voie de développement. Des séroprévalences élevées sont observées chez certaines espèces animales dans plusieurs pays européens. Cette étude a porté sur la transmission potentielle au porc d\'une souche de HEV provenant du sanglier (WbHEV) par inoculation intraveineuse ou par voie orale et sur l’étude des conséquences de l’infection du porc par une souche de WbHEV, une souche de WbHEV précédemment passée chez le porc et une souche porcine de HEV après inoculation orale. Tout d\'abord, une infection par voie intraveineuse a été réalisée au cours de laquelle cinq porcelets ont été répartis en deux groupes. Le premier était constitué de trois porcs inoculés avec du WbHEV et le second, de deux porcs inoculés avec un foie de porc négatif envers le HEV. Tous les porcs ont été euthanasiés et autopsiés 8, 9 et 10 jours après l’inoculation. Cette première expérience avait pour objectif d’obtenir suffisamment de virus en vue de réaliser les inoculations par voie orale. Elle a également permis d’étudier l’infectivité d’une souche de HEV-3 provenant du sanglier chez le porc. Ensuite, une infection par voie orale a été réalisée sur 12 porcelets répartis en 4 groupes inoculés respectivement avec une souche de WbHEV, une souche de WbHEV précédemment passée chez le porc, une souche porcine de HEV et un foie de porc HEV négatif. Cette expérience a duré 56 jours. Les échantillons récoltés ont ensuite été analysés par qRT-PCR, ELISA, Western blot et histopathologie. Le nombre de porcs virémiques était plus faible après infection orale qu’après inoculation intraveineuse. Ce résultat contraste avec la présence du HEV dans les matières fécales des porcs au cours des deux expériences. Les résultats montrent également une propagation du virus dans différents organes après inoculation intraveineuse, mais pas après inoculation par voie orale. Cette étude fournit la première preuve expérimentale de la propagation précoce du virus dans l\'organisme après infection intraveineuse avec une souche de HEV provenant du sanglier et montre qu’une telle souche pourrait être naturellement transmise entre les sangliers et les porcs, mais aussi entre porcs et donc survivre dans la population porcine. [less ▲]

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See detailDes pratiques enseignantes qui font obstacle au rôle des modèles dans la construction des savoirs scientifiques
Dontaine, Matthieu; Heins, Pascal ULg; Hindryckx, Marie-Noëlle ULg et al

Conference (2016, March)

Dans une perspective comparatiste, des didacticiens de plusieurs disciplines (biologie, chimie, histoire de l’art, mathématique et physique) ont étudié des pratiques enseignantes faisant obstacle au rôle ... [more ▼]

Dans une perspective comparatiste, des didacticiens de plusieurs disciplines (biologie, chimie, histoire de l’art, mathématique et physique) ont étudié des pratiques enseignantes faisant obstacle au rôle des modèles dans la construction des savoirs scientifiques. Leur réflexion croisée les a amenés à considérer des niveaux élevés de l’échelle de codétermination didactique de Chevallard (2012) pour identifier des indicateurs d’une certaine forme de positivisme empirique dans l’épistémologie spontanée des enseignants. Cette posture s’exprime plus ou moins différemment d’une discipline à l’autre mais le fait que les modèles et théories enseignées ont fait ou non l’objet d’une standardisation au sein de communautés scientifiques savantes déterminent fortement leur transposition didactique. De ce point de vue, l’exemple de l’histoire de l’art a joué un rôle méthodologique important permettant de contraster et de questionner les pratiques dans les autres disciplines. Ce questionnement s’inscrit dans un objectif à plus long terme qui est la reproblématisation (au sens de Orange, 2005) d’enseignements relatifs aux disciplines enseignées. [less ▲]

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See detailCalcifications articulaires, péri et juxtarticulaires « physiologiques » chez le chien
François, Marion; Bolen, Géraldine ULg

in Monde Vétérinaire (Le) (2016), (158), 14-17

Il existe, chez le chien, de nombreuses petites calcifications péri-, juxta- et articulaires « physiologiques » avec une présence inconstante, qui peuvent être confondues avec des lésions type fragment ... [more ▼]

Il existe, chez le chien, de nombreuses petites calcifications péri-, juxta- et articulaires « physiologiques » avec une présence inconstante, qui peuvent être confondues avec des lésions type fragment. Une bonne connaissance de leur localisation anatomique permet de distinguer les variations anatomiques normales des lésions pathologiques. Cet article reprend une liste de ces principales calcifications « physiologiques » pouvant être retrouvées sur des radiographies. [less ▲]

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See detailOrphan Black and Literature
Guesse, Carole ULg

Conference (2016, March)

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See detailLe parc scientifique du Sart Tilman, "Liege Science Park"
Merenne-Schoumaker, Bernadette ULg

in Pierre Geurts, Caroline Lamarche (Ed.) Dérivations 2 Pour le débat urbain (2016)

L'article retrace l'histoire du parc scientifique de Liège et tente d'en montrer les impacts sur le redéploiement régional. Il cherche aussi à développer une réflexion sur le concept de parc scientifique ... [more ▼]

L'article retrace l'histoire du parc scientifique de Liège et tente d'en montrer les impacts sur le redéploiement régional. Il cherche aussi à développer une réflexion sur le concept de parc scientifique, ses liens avec la recherche ainsi que les enjeux et défis liés au futur du tout parc de ce genre [less ▲]

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See detailSouthern Blues Night , Heerlen (Hollande) 19 mars 2016
Sacré, Robert ULg

E-print/Working paper (2016)

Compte rendu de la Southern Blues Night annuelle de Heerlen aux Pays Bas, avec photos

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See detailNewborn screening for sickle cell disease : 13 years at the CHR "La Citadelle", Liège
Sepulchre, Edith; Ketelslegers, Olivier; Minon, Jean-Marc et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2016, March), 18(1), 107

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See detailAzacytidine Enhances Regulatory T-Cells In Vivo and Prevents Experimental Xenogeneic Graft-Versus-Host Disease
Ehx, Grégory ULg; Fransolet, Gilles ULg; de Leval, Laurence ULg et al

in Biology of Blood and Marrow Transplantation (2016, March), 22(3), 393

Background. The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 ... [more ▼]

Background. The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Tregs). Objective. We investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) in a humanized murine model of transplantation, and described the impact of the drug on human T cells in vivo. Methods. In order to induce xGVHD, human peripheral blood mononuclear cells (huPBMC) were administered intravenously in NOD-scid IL-2Rγnull (NSG) mice. Results. AZA successfully improved both survival (p<0.0001) and xGVHD scores (p<0.0001). Further, AZA significantly decreased human T-cell proliferation as well as INF-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA administration significantly increased the function, proliferation and frequency of Tregs through demethylation of FOXP3i1 and higher secretion of IL-2 by conventional T cells due to IL2 gene promoter site 1 demethylation. Interestingly, among AZA-treated mice surviving the acute phase of xGVHD, there was an inverse correlation between the presence of Tregs and signs of chronic GVHD. Finally, Tregs harvested from the spleen of AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Conclusion. These findings emphasize a potential role for AZA as prevention or treatment of GVHD and other autoimmune diseases. [less ▲]

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See detailProgressive Current Source Models in Magnetic Vector Potential Finite-Element Formulations
Dular, Patrick ULg; Kuo-Peng, Patrick; Ferreira da Luz, Mauricio V. et al

in IEEE Transactions on Magnetics (2016), 52(3),

Progressive refinements of the current sources in magnetic vector potential finite-element (FE) formulations are done with a subproblem method. The sources are first considered through magnetomotive force ... [more ▼]

Progressive refinements of the current sources in magnetic vector potential finite-element (FE) formulations are done with a subproblem method. The sources are first considered through magnetomotive force or Biot–Savart models up to their volume FE models, from statics to dynamics. A novel way to define the source fields is proposed to lighten the computational efforts, through the conversion of the common volume sources to surface sources, without the need for any preresolution. Accuracy improvements can then be obtained for local currents and fields, and global quantities, i.e., inductances, resistances, Joule losses, and forces. [less ▲]

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See detailComputation of Source for Non-Meshed Coils in a Reduced Domain with A–V Formulation
Ferrouillat, Pauline; Guérin, Christophe; Meunier, Gérard et al

in IEEE Transactions on Magnetics (2016), 52(3),

The discretized source magnetic vector potential Aj, projected from source field Hs with H(curl,Ω) semi-norm, is studied for non-meshed coils with magnetic vector potential A and electric scalar potential ... [more ▼]

The discretized source magnetic vector potential Aj, projected from source field Hs with H(curl,Ω) semi-norm, is studied for non-meshed coils with magnetic vector potential A and electric scalar potential V formulation. As a novelty, source potential Aj is computed in a reduced domain Ωred instead of the complete domain Ω. For domains with fixed and moving parts, potential Aj can be computed on each part, for each of the related current sources, with no need to ensure its continuity between these parts. [less ▲]

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See detailFinite-Element Homogenization of Laminated Iron Cores With Inclusion of Net Circulating Currents Due to Imperfect Insulation
Gyselinck, Johan; Dular, Patrick ULg; Krähenbühl, Laurent et al

in IEEE Transactions on Magnetics (2016), 52(3),

This paper deals with the time-domain homogenization of laminated cores in 2-D or 3-D finite-element (FE) models of electromagnetic devices, allowing for net circulating current in the laminations (e.g ... [more ▼]

This paper deals with the time-domain homogenization of laminated cores in 2-D or 3-D finite-element (FE) models of electromagnetic devices, allowing for net circulating current in the laminations (e.g., due to imperfect or damaged insulation). The homogenization is based on the expansion of the induction throughout the lamination thickness using a set of orthogonal polynomial basis functions (BFs), in conjunction with the magnetic vector potential formulation. These BFs allow for net flux, net current, and skin effect in the laminations; by choosing the number of BFs, one can compromise between accuracy and computational cost. The approach is validated through a linear 2-D test case with in-plane imposed and induced current density. A brute-force model, in which all laminations are finely meshed, produces the reference solution. The extension to nonlinear 3-D problems is expected to be straightforward. [less ▲]

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See detailDesign Sensitivity Analysis for Shape Optimization of Nonlinear Magnetostatic Systems
Kuci, Erin ULg; Henrotte, François; Duysinx, Pierre ULg et al

in IEEE Transactions on Magnetics (2016), 52(3),

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative ... [more ▼]

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative concept of differential geometry where the flow is the velocity field associated with the modification of a geometrical parameter in the model. The resulting sensitivity formulas can be expressed naturally in a finite element setting through a volume integral in the layer of elements connected to the surface undergoing shape modification. The accuracy of the methodology is analyzed on a 2D model of an interior permanent magnet motor (IPM), and on a 3D model of a permanent magnet system. [less ▲]

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See detailComparison of Nonlinear Domain Decomposition Schemes for Coupled Electromechanical Problems
Halbach, Alexandre ULg; Dular, Patrick ULg; Geuzaine, Christophe ULg

in IEEE Transactions on Magnetics (2016), 52(3),

The aim of this paper is to compare several domain decomposition schemes for nonlinear, coupled electromechanical problems. Both staggered and monolithic electrostatic/elastic formulations are considered ... [more ▼]

The aim of this paper is to compare several domain decomposition schemes for nonlinear, coupled electromechanical problems. Both staggered and monolithic electrostatic/elastic formulations are considered for the multiphysics problem. The domain decomposition is applied either to a single multiphysics iteration, which corresponds to a linear problem, or to the full nonlinear multiphysics resolution. In the latter, the problem solved at each domain decomposition iteration is nonlinear. The influence of the elastic wave’s frequency and the electrostatic potential on the convergence rate and the computational cost of the algorithm is investigated on a 2-D model of a vibrating micromembrane array. [less ▲]

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