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See detailService de numérisation à la demande dans les Bibliothèques de l'Université de Liège : Rapport sur la phase pilote de mars à décembre 2016
Simon, Stéphanie ULg; Bougrine, Hassan ULg; Renaville, François ULg

Report (2017)

Le système de gestion de bibliothèque Alma intègre un processus de gestion des documents numériques (stockage et/ou fourniture). Une analyse préalable sur les possibilités, avantages et limites d'un ... [more ▼]

Le système de gestion de bibliothèque Alma intègre un processus de gestion des documents numériques (stockage et/ou fourniture). Une analyse préalable sur les possibilités, avantages et limites d'un service de numérisation à la demande géré par Alma, dans le contexte des Bibliothèques de l'Université, a été réalisée en 2015. L'analyse a suggéré la mise en place, pour une phase pilote, d'un service de numérisation partielle à destination des membres du personnel. Le présent rapport fait le point sur cette phase pilote (mars-décembre 2016) et adresse des recommandations pour l'avenir. [less ▲]

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See detailInvestigation of the copolymerization behavior of a cyclic carbonate with vinyl acetate using CMRP
Scholten, Philip ULg; Demarteau, Jérémy ULg; Debuigne, Antoine ULg et al

Poster (2017, March)

Ethylene is an unconjugated monomer difficult to copolymerise in a controlled fashion using common radical or coordination-insertion polymerisation. Cobalt-mediated radical polymerisation (CMRP) provides ... [more ▼]

Ethylene is an unconjugated monomer difficult to copolymerise in a controlled fashion using common radical or coordination-insertion polymerisation. Cobalt-mediated radical polymerisation (CMRP) provides a powerful means to radically copolymerise ethylene in a controlled fashion under mild conditions.[1][2] In addition, different copolymer structures, such as block or alternating, can be accessed. ACO2-based cyclic carbonate was chosen as a promising comonomer but conflicting reports on the copolymer structure have been reported.[3][4] To better understand the copolymerisation behaviour of this monomer, model copolymerisations with vinyl acetate were performed and are reported below with the aim of gaining insights into the copolymersiation behaviour, which will allow us to better tackle ethylene copolymerisations. [less ▲]

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See detailInactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 cells by a multiplex CRISPR/Cas9 strategy results in glycoproteins without plant-specific glycans
Mercx, Sébastien; Smargiasso, Nicolas ULg; Chaumont, François et al

in Frontiers in Plant Science (2017), 8

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with planttypical residues [β(1,2)-xylose and core α(1,3 ... [more ▼]

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with planttypical residues [β(1,2)-xylose and core α(1,3)-fucose], which can greatly impact the immunogenicity, allergenicity, or activity of the protein. Two enzymes are responsible for the addition of plant-specific glycans: β(1,2)-xylosyltransferase (XylT) and α(1,3)- fucosyltransferase (FucT). Our aim consisted of knocking-out two XylT genes and four FucT genes (12 alleles altogether) in Nicotiana tabacum BY-2 suspension cells using CRISPR/Cas9. Three XylT and six FucT sgRNAs were designed to target conserved regions. After transformation of N. tabacum BY-2 cells with genes coding for sgRNAs, Cas9, and a selectable marker (bar), transgenic lines were obtained and their extracellular as well as intracellular protein complements were analyzed by Western blotting using antibodies recognizing β(1,2)-xylose and α(1,3)-fucose. Three lines showed a strong reduction of β(1,2)-xylose and α(1,3)-fucose, while two lines were completely devoid of them, indicating complete gene inactivation. The absence of these carbohydrates was confirmed by mass spectrometry analysis of the extracellular proteins. PCR amplification and sequencing of the targeted region indicated small INDEL and/or deletions between the target sites. The KO lines did not show any particular morphology and grew as the wild-type. One KO line was transformed with genes encoding a human IgG2 antibody. The IgG2 expression level was as high as in a control transformant which had not been glycoengineered. The IgG glycosylation profile determined by mass spectrometry confirmed that no β(1,2)-xylose or α(1,3)-fucose were present on the glycosylation moiety and that the dominant glycoform was the GnGn structure. These data represent an important step toward humanizing the glycosylation of pharmacological proteins expressed in N. tabacum BY-2 cells. © 2017 Mercx, Smargiasso, Chaumont, De Pauw, Boutry and Navarre. [less ▲]

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See detailGeneration of High-Amylose Rice through CRISPR/Cas9-Mediated Targeted Mutagenesis of Starch Branching Enzymes
Sun, Yongwei ULg; Xia, Lanqin; Francis, Frédéric ULg et al

in Frontiers in Plant Science (2017), 8

Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits. Previous studies using chemical mutagenesis or RNA interference have demonstrated that starch branching ... [more ▼]

Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits. Previous studies using chemical mutagenesis or RNA interference have demonstrated that starch branching enzyme (SBE) plays a major role in determining the fine structure and physical properties of starch. However, it remains a challenge to control starch branching in commercial lines. Here, we use CRISPR/Cas9 technology to generate targeted mutagenesis in SBEI and SBEIIb in rice. The frequencies of obtained homozygous or bi-allelic mutant lines with indels in SBEI and SBEIIb in T0 generation were from 26.7 to 40%. Mutations in the homozygous T0 lines stably transmitted to the T1 generation and those in the bi-allelic lines segregated in a Mendelian fashion. Transgene-free plants carrying only the frame-shifted mutagenesis were recovered in T1 generation following segregation. Whereas no obvious differences were observed between the sbeI mutants and wild type, sbeII mutants showed higher proportion of long chains presented in debranched amylopectin, significantly increased AC and RS content to as higher as 25.0% and 9.8%, respectively, and thus altered fine structure and nutritional properties of starch. Taken together, our results demonstrated for the first time the feasibility to create high-amylose rice through CRISPR/Cas9-mediated editing of SBEIIb. [less ▲]

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See detailQuantum fidelity of symmetric multipartite states
Neven, Antoine ULg; Mathonet, Pierre ULg; Gühne, Otfried et al

Conference (2017, March)

For two symmetric quantum states one may be interested in maximizing the overlap under local operations applied to one of them. The question arises whether the maximal overlap can be obtained by applying ... [more ▼]

For two symmetric quantum states one may be interested in maximizing the overlap under local operations applied to one of them. The question arises whether the maximal overlap can be obtained by applying the same local operation to each party. We show [1] that for two symmetric multiqubit states and local unitary transformations this is the case; the maximal overlap can be reached by applying the same unitary matrix everywhere. For local invertible operations (stochastic local operations assisted by classical communication equivalence), however, we present counterexamples, demonstrating that considering the same operation everywhere is not enough. [less ▲]

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See detailL’agroécologie, vers la concrétisation d’une utopie ?
Bindelle, Jérôme ULg; De Schutter, Olivier; Dufrêne, Marc ULg et al

Article for general public (2017)

L’agroécologie prône une vision plus responsable de l’agriculture, plus respectueuse de la Terre et de l’Homme. Elle trouve une résonance croissante chez nous, tant dans la société que dans le monde ... [more ▼]

L’agroécologie prône une vision plus responsable de l’agriculture, plus respectueuse de la Terre et de l’Homme. Elle trouve une résonance croissante chez nous, tant dans la société que dans le monde agricole. Quels sont les enjeux de l’agriculture de demain auquel tente de répondre ce modèle alternatif ? Comment creuse-t-il son sillon dans notre paysage agricole ? Quels sont les principes, freins et leviers pour sa mise en oeuvre et sa pérennisation ? [less ▲]

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See detailErnst Mach, psychologue de la forme ?
Zincq, Aurélien ULg

in Philosophie (2017), 133

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See detailArtemisia campestris L.:Ethnomedical, phytochemical and pharmacological review
Dib, Ikram; Angenot, Luc ULg; Ziyyat, Abderrahim et al

in Journal of Herbal Medicine (2017), 7(1), 1-10

Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic ... [more ▼]

Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic, antidiabetic, antihypertensive, emmenagogue, antivenom, and to treat digestive and cutaneous problems. an exhaustive bibliographic research of this plant has been carried out by means of scientific engines and databases like Google scholar, PubMed, Sciencedirect and sciFinder; as a result, it has been found that this herb possesses a rich phytochemical content and a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic , antivenom and antitumor effects. In an aim to highlight the importance of A. campestris L., this review has been established by discussing its ethnomedicinal, morphological, ecological, phytochemical, pharmacological and toxicological studies. [less ▲]

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See detailMultivariate analysis of 18F-DMFP PET data to assist the diagnosis of parkinsonism
Segovia, Fermin; Gorriz, Juan M.; Ramirez, Javier et al

in Frontiers in Neuroinformatics (2017)

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See detailComplication with convective core boundary
Thoul, Anne ULg

Conference (2017, March)

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See detailHow the reference values for serum parathyroid hormone concentration are (or should be) established?
Souberbielle, J.-C.; Brazier, F.; Piketty, M.-L. et al

in Journal of Endocrinological Investigation (2017), 40(3), 241-256

Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria ... [more ▼]

Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria for this population can be defined as any situation possibly inducing an increase or a decrease in PTH concentration. As recommended in the recent guidelines on the diagnosis and management of asymptomatic primary hyperparathyroidism, PTH reference values should be established in vitamin D-replete subjects with a normal renal function with possible stratification according to various factors such as age, gender, menopausal status, body mass index, and race. A consensus about analytical/pre-analytical aspects of PTH measurement is also needed with special emphasis on the nature of the sample (plasma or serum), the time and the fasting/non-fasting status of the blood sample. Our opinion is that blood sample for PTH measurement should be obtained in the morning after an overnight fast. Furthermore, despite longer stability of the PTH molecule in EDTA plasma, we prefer serum as it allows to measure calcium, a prerequisite for a correct interpretation of a PTH concentration, on the same sample. Once a consensus is reached, we believe an important international multicentre work should be performed to recruit a very extensive reference population of apparently healthy vitamin D-replete subjects with a normal renal function in order to establish the PTH normative data. Due to the huge inter-method variability in PTH measurement, a sufficient quantity of blood sample should be obtained to allow measurement with as many PTH kits as possible. [less ▲]

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See detailIntroduction à l’evidence-based practice en psychologie
Durieux, Nancy ULg; Etienne, Anne-Marie ULg; Willems, Sylvie ULg

Article for general public (2017)

Beaucoup d’encre coule au sujet de l’evidence-based practice (EBP) en psychologie, approche recommandée par certains collègues, mais décriée par d’autres… Cet article a pour objectif d’introduire ... [more ▼]

Beaucoup d’encre coule au sujet de l’evidence-based practice (EBP) en psychologie, approche recommandée par certains collègues, mais décriée par d’autres… Cet article a pour objectif d’introduire brièvement l’EBP auprès des praticiens. Les auteurs tenteront de montrer que, malgré les obstacles et les développements essentiels pour que cette approche puisse être intégrée dans le quotidien des psychologues, l’EBP constitue une opportunité de faire évoluer les pratiques professionnelles et de permettre une meilleure valorisation de la psychologie. [less ▲]

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See detailInternational Osteoporosis Foundation and European Calcified Tissue Society working group. Recommendations for the screening of the adherence to oral bisphosphonates.
DIEZ-PEREZ, A; NAYLOR, K.E.; ABRAHAMSEN, B et al

in Osteoporosis International (2017), 28(3), 767-774

Summary: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the ... [more ▼]

Summary: Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the treatment and also other potential issues with the drug. Introduction: Low adherence to oral bisphosphonates is a common problem that jeopardizes the efficacy of treatment of osteoporosis. No clear screening strategy for the assessment of compliance is widely accepted in these patients. Methods: The International Osteoporosis Foundation and the European Calcified Tissue Society have convened a working group to propose a screening strategy to detect a lack of adherence to these drugs. The question to answer was whether the bone turnover markers (BTMs) PINP and CTX can be used to identify low adherence in patients with postmenopausal osteoporosis initiating oral bisphosphonates for osteoporosis. The findings of the TRIO study specifically address this question and were used as the basis for testing the hypothesis. Results: Based on the findings of the TRIO study, specifically addressing this question, the working group recommends measuring PINP and CTX at baseline and 3 months after starting therapy to check for a decrease above the least significant change (decrease of more than 38% for PINP and 56% for CTX). Detection rate for the measurement of PINP is 84%, for CTX 87% and, if variation in at least one is considered when measuring both, the level of detection is 94.5%. Conclusions: If a significant decrease is observed, the treatment can continue, but if no decrease occurs, the clinician should reassess to identify problems with the treatment, mainly low adherence. [less ▲]

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See detailPublic Health impact and economic evaluation of vitamin D-fortified dairy products for fracture prevention in France.
HILIGSMANN, M.; BURLET, N.; FARDELLONE, P. et al

in Osteoporosis International (2017), 28(3), 833-840

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French ... [more ▼]

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French population aged over 60 years. Introduction: This study aims to assess the public health and economic impact of vitamin D-fortified dairy products in the general French population aged over 60 years. Methods: We estimated the lifetime health impacts expressed in number of fractures prevented, life years gained, and quality-adjusted life years (QALY) gained of the recommended intake of dairy products in the general French population over 60 years for 1 year (2015). A validated microsimulation model was used to simulate three age cohorts for both women and men (60–69, 70–79, and >80 years). The incremental cost per QALY gained of vitamin D-fortified dairy products compared to the absence of appropriate intake was estimated in different populations, assuming the cost of two dairy products per day in base case. Results: The total lifetime number of fractures decreased by 64,932 for the recommended intake of dairy products in the general population over 60 years, of which 46,472 and 18,460 occurred in women and men, respectively. In particular, 15,087 and 4413 hip fractures could be prevented in women and men. Vitamin D-fortified dairy products also resulted in 32,569 QALYs and 29,169 life years gained. The cost per QALY gained of appropriate dairy intake was estimated at €58,244 and fall below a threshold of €30,000 per QALY gained in women over 70 years and in men over 80 years. Conclusion: Vitamin D-fortified dairy products have the potential to substantially reduce the burden of osteoporotic fractures in France and seem an economically beneficial strategy, especially in the general population aged above 70 years. [less ▲]

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See detailConstruire un système de reconnaissance de l'économie sociale en Wallonie. Analyse des résultats issus des ateliers scénarios menés dans le cadre du projet SECOIA
Stassart, Isalyne ULg; Erpicum, Martin ULg; Fallon, Catherine ULg et al

Report (2017)

Quelles sont les pratiques communes aux entreprises d’économie sociale ? Quelles sont les dimensions qui pourraient les distinguer des autres entreprises dites capitalistiques ? Les membres actifs de ... [more ▼]

Quelles sont les pratiques communes aux entreprises d’économie sociale ? Quelles sont les dimensions qui pourraient les distinguer des autres entreprises dites capitalistiques ? Les membres actifs de l’économie sociale peuvent-ils proposer un ou plusieurs systèmes de reconnaissance de leurs spécificités ? Et sur base de quels indicateurs ? Tel était l’objet du troisième volet du projet SECOIA (projet de 22 mois commandité par la Région wallonne) qui visait à élaborer de manière participative et itérative un ou plusieurs système(s) de reconnaissance des entreprises de l’économie sociale. L’analyse de trois ateliers scénarios menés en décembre et février dernier avec 32 participants représentant les petites, moyennes et grandes entreprises de l’économie sociale en Région wallonne met en évidence une dimension transversale, et six dimensions spécifiques propres à l’économie sociale. [less ▲]

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See detailNutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
Beaudart, Charlotte ULg; Dawson, A.; Shaw, S. C. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2017), 28(6), 1817-33

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise ... [more ▼]

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be limited. INTRODUCTION: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. They concluded that further studies were needed to provide evidence upon which public health and clinical recommendations could be based. The purpose of the present work was to update the prior systematic review and include studies published up to October 2015. METHODS: Using the electronic databases MEDLINE and EMBASE, we identified RCTs which assessed the combined effect of exercise training and nutritional supplementation on muscle strength, muscle mass, or physical performance in subjects aged 60 years and over. Study selection and data extraction were performed by two independent reviewers. RESULTS: The search strategy identified 21 additional RCTs giving a total of 37 RCTs. Studies were heterogeneous in terms of protocols for physical exercise and dietary supplementation (proteins, essential amino acids, creatine, beta-hydroxy-beta-methylbuthyrate, vitamin D, multi-nutrients, or other). In 79% of the studies (27/34 RCTs), muscle mass increased with exercise but an additional effect of nutrition was only found in 8 RCTs (23.5%). Muscle strength increased in 82.8% of the studies (29/35 RCTs) following exercise intervention, and dietary supplementation showed additional benefits in only a small number of studies (8/35 RCTS, 22.8%). Finally, the majority of studies showed an increase of physical performance following exercise intervention (26/28 RCTs, 92.8%) but interaction with nutrition supplementation was only found in 14.3% of these studies (4/28 RCTs). CONCLUSION: Physical exercise has a positive impact on muscle mass and muscle function in healthy subjects aged 60 years and older. The biggest effect of exercise intervention, of any type, has been seen on physical performance (gait speed, chair rising test, balance, SPPB test, etc.). We observed huge variations in regard to the dietary supplementation protocols. Based on the included studies, mainly performed on well-nourished subjects, the interactive effect of dietary supplementation on muscle function appears limited. [less ▲]

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See detailManagement of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS and SIOG.
HADJI, P.; AAPRO, M.S.; BODY, J.J. et al

in Journal of Bone Oncology (2017), 23(7), 1-12

Background: Several guidelines have been reported for bone-directed treatment in women with early breast cancer (EBC) for averting fractures, particularly during aromatase inhibitor (AI) therapy. Recently ... [more ▼]

Background: Several guidelines have been reported for bone-directed treatment in women with early breast cancer (EBC) for averting fractures, particularly during aromatase inhibitor (AI) therapy. Recently, a number of studies on additional fracture related risk factors, new treatment options as well as real world studies demonstrating a much higher fracture rate than suggested by randomized clinical controlled trials (RCTs). Therefore, this updated algorithm was developed to better assess fracture risk and direct treatment as a position statement of several interdisciplinary cancer and bone societies involved in the management of AI-associated bone loss (AIBL). Patients and methods: A systematic literature review identified recent advances in the management of AIBL. Results with individual agents were assessed based on trial design, size, follow-up, and safety. Results: Several fracture related risk factors in patients with EBC were identified. Although, the FRAX algorithm includes fracture risk factors (RF) in addition to BMD, it does not seem to adequately address the effects of AIBL. Several antiresorptive agents can prevent and treat AIBL. However, concerns regarding compliance and longterm safety remain. Overall, the evidence for fracture prevention is strongest for denosumab 60 mg s.c. every 6 months. Additionally, recent studies as well as an individual patient data meta-analysis of all available randomized trial data support additional anticancer benefits from adjuvant bisphosphonate treatment in postmenopausal women with a 34% relative risk reduction in bone metastasis and 17% relative risk decrease in breast cancer mortality that needs to be taken into account when advising on management of AIBL. Conclusions: In all patients initiating AI treatment, fracture risk should be assessed and recommendation with regard to exercise and calcium/vitamin D supplementation given. Bone-directed therapy should be given to all patients with a T-score<−2.0 or with a T-score of<–1.5 SD with one additional RF, or with ≥2 risk factors (without BMD) for the duration of AI treatment. Patients with T-score>−1.5 SD and no risk factors should be managed based on BMD loss during the first year and the local guidelines for postmenopausal osteoporosis. Compliance should be regularly assessed as well as BMD on treatment after 12 - 24 months. Furthermore, because of the decreased incidence of bone recurrence and breast cancer specific mortality, adjuvant bisphosphonates are recommended for all postmenopausal women at significant risk of disease recurrence. [less ▲]

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