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See detailDiversification artistique et mobilisations sociopolitiques dans les villes multiculturelles
Martiniello, Marco ULg

Conference given outside the academic context (2015)

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See detailVoci sul sacco di Roma: Guicciardini, Cellini, Sanudo
Miesse, Hélène ULg

Conference given outside the academic context (2015)

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See detailBiodistribution and radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H: First-in-human study.
Bretin, Florian ULg; Bahri, Mohamed Ali ULg; BERNARD, Claire ULg et al

in Molecular Imaging & Biology (2015), 17

Abstract- [18F]UCB-H is a novel radiotracer with a high affinity for SV2A, a protein expressed in synaptic vesicles. SV2A is the binding site of levetiracetam, a “first in class” antiepileptic drug with a ... [more ▼]

Abstract- [18F]UCB-H is a novel radiotracer with a high affinity for SV2A, a protein expressed in synaptic vesicles. SV2A is the binding site of levetiracetam, a “first in class” antiepileptic drug with a distinct but still poorly understood mechanism of action. The objective of this study was to determine the biodistribution and radiation dosimetry of [18F]UCB-H in a human clinical trial and to establish injection limits according to biomedical research guidelines. Additionally, the clinical radiation dosimetry results were compared to estimations in previously published preclinical data. Dynamic whole body PET/CT imaging was performed over approximately 110 minutes on five healthy male volunteers after injection of 144.5 ± 7.1 MBq (range, 139.1 – 156.5 MBq) of [18F]UCB-H. Major organs were delineated on CT images and time-activity curves were obtained from co-registered dynamic PET emission scans. Time-integrated activity coefficients were calculated as area under the curve using trapezoidal numerical integration. Urinary excretion data based on PET-activities including voiding was simulated using the dynamic bladder module of OLINDA/EXM. The radiation dosimetry was calculated using OLINDA/EXM. The effective dose to the OLINDA/EXM 70 kg standard male was 1.54E-02 ± 6.84E-04 mSv/MBq, with urinary bladder wall, gallbladder wall and the liver receiving the highest absorbed dose. The brain, the tracer’s main organ of interest, received an absorbed dose of 1.89E-02 ± 2.32E-03 mGy/MBq. This first human dosimetry study of [18F]UCB-H indicated that the tracer shows similar radiation burdens to widely used common clinical tracers. Single injections of at maximum 672 MBq for USA practice and 649 MBq for European practice keep radiation exposure below recommended limits. Recently published preclinical dosimetry data extrapolated from mice provided satisfactory prediction of total body and effective dose, but showed significant differences in organ absorbed doses compared to human data. [less ▲]

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See detailAcheter, cuisiner, transmettre. Diversification des choix alimentaires des familles marocaines en contexte migratoire.
Mescoli, Elsa ULg

Conference (2015, January 16)

Les études autour des cultures alimentaires contemporaines, menées dans le cadre de différentes disciplines, mettent en évidence le dynamisme interne et interrelationnels qui caractérise les gastronomies ... [more ▼]

Les études autour des cultures alimentaires contemporaines, menées dans le cadre de différentes disciplines, mettent en évidence le dynamisme interne et interrelationnels qui caractérise les gastronomies, plutôt qu’une « pureté » et « immobilisme » originels (La Cecla, 1998). Cependant, lorsqu’il s’agit d’analyser le rapport entre alimentation et migration, une essentialisation des habitudes se produit. Celles des migrants sont souvent considérées comme résistantes au changement, et elles deviennent les indicateurs de la disposition à « s’intégrer » à la société locale. Dans ce contexte discursif, où différentes règles interagissent en déterminant l’inclusion ou l’exclusion des individus de certains groupes (la communauté majoritaire, la collectivité « saine » etc.), les familles issues de la migration vivent et exercent leur quotidien alimentaire. Bricoler avec ces règles surdéterminées leur permet d’exprimer une créativité qui se met en œuvre à plusieurs niveaux : celui de l’approvisionnement, celui de la préparation des repas, celui de la transmission des savoir-faire entre les générations. Cette communication vise à présenter les données collectées au cours d’un travail de terrain ethnographique mené pendant dix-huit mois au milieu d’un groupe de femmes marocaines résidentes dans la province de Milan en Italie. Observations et entretiens ont été conduits à la fois dans les maisons et les espaces publics. Ils portaient sur les (micro)pratiques alimentaires entendues comme facteurs centraux dans la définition du soi, suivant une approche praxéologique à la subjectivation (Warnier, 2001). Grâce à cette analyse, il sera possible de constater qu’une culture alimentaire composite se redéfinit au niveau familial, bien qu’elle ne soit pas exemptée de l’effet de dynamiques culturelles, sociales, économiques et politiques plus amples et apparemment structurantes. On assiste à une diversification des pratiques. D’un côté, avec leurs déplacements pour faire leurs achats, femmes et hommes dessinent des chorégraphies complexes à l’intérieur de la ville, et ils engagent aussi une circulation transnationale des biens alimentaires. De l’autre côté, mères et filles puisent de savoirs différents pour faire face à leurs exigences, en s’appuyant sur une pluralité d’outils (mémoire incorporée, bouche à oreille, livres de recettes, internet). Ainsi, les familles continuent d’effectuer un choix actif en matière d’alimentation. L’analyse sera accompagnée par des supports visuels. [less ▲]

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See detailCancer metabolism reprogramming in response to anti-angiogenic therapy
Sounni, Nor Eddine ULg

Poster (2015, January 15)

In this study, we have explored the tumor adaptation to antiangiogenic therapy with the multitarget receptor tyrosine kinase inhibitors (RTKIs) Sunitinib and sorafenib. These RTKIs are currently in ... [more ▼]

In this study, we have explored the tumor adaptation to antiangiogenic therapy with the multitarget receptor tyrosine kinase inhibitors (RTKIs) Sunitinib and sorafenib. These RTKIs are currently in clinical use for multiple tumor types and confer increased overall or progression-free survival. However, antiangiogenic drugs demonstrate only relatively modest survival benefits and transient responses to treatment. Furthermore, preclinical studies suggest that RTKIs withdrawal results in accelerated tumor progression and metastasis. By applying the RTKIs treatment to 5 preclinical models of cancer development with global screening technologies, we found that tumors shift their metabolism during antiangiogenic therapy and acquire more aggressive phenotype after treatment cessation. We found that accelerated tumor growth and metastasis upon RTKIs withdrawal was associated with decreased glucose metabolism, increased lipid metabolism, and activation of the tricarboxylic acid (TCA) cycle. In particular, withdrawal of RTKIs resulted in elevated levels of fatty acid synthase (FASN) and acetyl-CoA carboxylase and adipocyte accumulation in tumors. Antiangiogenic therapy induced a metabolic shift in cancer and stromal cells to a glycolytic and hypoxic state during treatment, which was reversed upon therapy withdrawal, resulting in a shift to de novo lipogenesis and increased TCA cycle activity to promote tumor regrowth. Targeting lipid metabolism using the FASN inhibitor orlistat or by specific knockdown of FASN suppressed the RTKIs withdrawal–associated tumor regrowth and metastasis. We will discuss the role for lipid metabolism in tumor adaptation to antiangiogenic therapy withdrawal. [less ▲]

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See detailPolitiques d'éducation et de formation : une approche par les capacités
Orianne, Jean-François ULg

Scientific conference (2015, January 13)

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See detailLa construcción de sujetos ambientales: los Huaorani del Ecuador
Escobar Jimenez, Kelly ULg

in Boletín de Antropología de la Universidad de Antioquia (2015), 30(49), 35-57

After a long nomadic identity among warriors, isolated people and environment destroy, the huaorani in the Ecuadorian Amazon have turned “on environmental subjects par excellence”, and how this has ... [more ▼]

After a long nomadic identity among warriors, isolated people and environment destroy, the huaorani in the Ecuadorian Amazon have turned “on environmental subjects par excellence”, and how this has happened? Mobilizing the ethnographic data I obtained during my fieldwork in Yasuní and Arajuno (Ecuador) and second-hand information, the article focuses on describing how the intervention of exogenous actors, through devices indigenous land management and development sustainable, has gradually assimilated to environmental conservation, permeating the identity of the inhabitants of the Amazon rainforest. I use notions such as “dispositives” and “controversies analysis” (Actor network-theory), as well as the “environmental subjects” (Agrawal, 2000). The background article aims to reflect on the ambiguity inherent to scientific construction of humans (local and scientific) and nonhuman in tropical rainforest. [less ▲]

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See detailProfession art-thérapeute?
Vandeninden, Elise ULg

Conference (2015, January 09)

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See detailLes mots, la mort, les sorts. Jeanne Favret-Saada
Vangeebergen, Thomas ULg

Learning material (2015)

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See detailManaging the carnivore comeback: assessing the adaptive capacity of the Eurasian lynx (Lynx lynx) to cohabit with humans in shared landscapes
Bouyer, Yaëlle ULg

Doctoral thesis (2015)

Conflicts between humans and large carnivores are one of the most visible examples of the challenges that arise when seeking to achieve coexistence between humans and wildlife. With their large spatial ... [more ▼]

Conflicts between humans and large carnivores are one of the most visible examples of the challenges that arise when seeking to achieve coexistence between humans and wildlife. With their large spatial requirements and predatory behavior, large carnivores are among the most difficult species to preserve in our modern day landscapes. Although large carnivores are usually considered as the epitomes of wilderness, because of human population growth and habitat fragmentation they are inexorably and increasingly faced with the need to live in human-modified landscapes. As a direct consequence, conflicts over depredation on livestock, competition for game species and sometimes over human injury or death will only increase if clear management measures are not taken. This is particularly true in Europe, where, after many decades of absence, large carnivores are recolonizing areas where millions of people are present and where landscapes have been drastically modified. Two approaches to integrating wildlife into a human-dominated world have been proposed at an international scale. The first solution is called land sparing, in which wildlife lives exclusively in protected or wilderness areas where contact between animals and humans will be reduced to the minimum. The second solution, called land sharing, proposes to integrate human activities and wildlife in the same landscapes in non-protected interface zones in what is often called a coexistence approach. In a context of scarce true wilderness areas and a continuum of human-modified habitats, land sharing (i.e. the coexistence approach) is seen as the only possible approach valid for Europe. While a coexistence approach can be readily implemented with smaller species, it can represent a major challenge for species with large space requirements and with predatory behavior. To help manage these species in a long-term conservation vision and to predict where potential conflicts could arise between humans and carnivores, information on large carnivores and their habitat use in anthropogenic landscapes is a pre-requisite. With the return of Eurasian lynx Lynx lynx in Western Europe, the most densely populated areas of the continent_ information on the species tolerance to human land use will help predict where it is likely to occur in anthropogenic landscapes. Data collected in Scandinavia over 15 years were used to assess the use of landscape by lynx. In this study, we explored the effect of anthropogenic and environmental factors on Eurasian lynx habitat use in Scandinavia. The work was developed along two main axes. The first axis aims to explore large scale potential patterns of lynx distribution through transferability of results obtained from habitat modelling to geographically different areas. Transferability of results was tested in two steps. Firstly, transferability success (i.e. predictive ability of the map) was tested at a regional scale using data on roe-deer, the main prey of lynx, to create a map of relative distribution and abundance of prey in southeastern Norway (Chapter 1). Secondly, transferability success was assessed at a larger extent and using data obtained from different sampling method (Chapter 2). A habitat suitability map for Eurasian lynx was produced to be used in management planning in geographically differentiated lynx management zones in Scandinavia. The results indicated that transferability of results from one region to an ecologically different region must be taken with caution. Nevertheless, the habitat suitability maps we constructed on the basis of extrapolation are a valuable asset to help management of the Scandinavian lynx population. The second axis deals with lynx habitat use in relation to anthropogenic and environmental predictors. Lynx tolerance to human presence was first explored by looking at the orientation of home range in the landscape, taking into account proxies of human presence (Chapter 3). Values of these proxies were compared both inside home ranges and within a buffer surrounding the home ranges for several lynx inhabiting an anthropogenic gradient going from near-wilderness to urban periphery. Results showed a high diversity in the extent to which individual lynx are exposed to human influence, indicating that lynx are highly adaptable in terms of living space. Lynx seemed to be able to orientate their home range in order to avoid highest human impacts and select for areas of medium human impacts. Building on these results, finer scale information on lynx habitat use in an anthropogenic landscape were obtained taking into consideration different types of behavior (day-beds, moving and killing) displayed by adult lynx, as well as the effect of cumulative anthropogenic pressures on habitat selection (Chapter 4). Our results showed that lynx select for areas with medium levels of human modification, avoiding both the areas with highest and least modification. Females in general appear to be less tolerant to human modification than males, especially for day-beds. Our study shows that Eurasian lynx can be considered as a species that is adaptable to human- induced changes in landscape even if its motivation to tolerate human presence is clearly linked to the presence and density level of its main prey, the roe deer. Our work shows that, contrary to much of the public and many conservation professionals’ opinions, land sharing with large carnivores in Europe may be possible – even in the immediate proximity to urban centers. However, it is important to bear in mind that these results were obtained from countries with a relatively low human population density; even though some individuals observed lived in the periphery of large cities, the level of habitat fragmentation is less severe than in most of Western Europe. In order to properly assess the capacity of Eurasian lynx to live in highly populated areas, such as the Benelux, more detailed information on lynx distribution from continental European will be needed. However, our results underline the value of combining both correlational and mechanistic studies, and the need for caution in extrapolating data too far from its original context. As large carnivore recovery continues to progress in Europe we may not yet have seen the limits of these species' abilities to adapt. [less ▲]

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See detailPetite chronique de l’évaluation : évoluer pour mieux évaluer ?
Detroz, Pascal ULg

Scientific conference (2015, January 08)

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See detailOptimal Enforcement of Competition Policy: The Commitments Procedure under Uncertainty
Gautier, Axel ULg

Scientific conference (2015, January 08)

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See detailLa période hollandaise en Belgique
Brüll, Christoph ULg

Conference given outside the academic context (2015)

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See detailEffect of stress path on the miniaturizatio size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Duchene, Laurent ULg et al

Conference (2015, January 04)

The mechanical behavior of mettalic materials deeply depends on the size of samples. For specimen dimensions de creasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of mettalic materials deeply depends on the size of samples. For specimen dimensions de creasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. This effect is triggered by the derease of the number of grains across the thickness ( also called thickness"t" over grain size "d" ratio). The objective of this work is to provide new experimental results in order to analyse the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensil tests, large tensile tests and shear tests have been performed on Ni sheets ( 0.5mm) with various grain sizes ensuring different t/d ratios. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanicval softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. Attempts of numerical simulations using strain gradient crystal plasticity model are also performed to confirm the role played by surface effects. [less ▲]

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See detailUpscaling of an electronic nose for continuously stirred tank reactor stability monitoring from pilot-scale to real-scale agricultural co-digestion biogas plant
Adam, Gilles ULg; Lemaigre, Sébastien; Goux, Xavier et al

in Bioresource Technology (2015), 178

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to ... [more ▼]

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, volatile fatty acids concentration and to other gas phase compounds. Multivariate statistical process control method, based on principal component analysis and the Hotelling's T² statistics was used to derive an indicator representative of the reactor state. At the pilot-scale level, the e-nose indicator was relevant and could distinguish 3 process states: steady-state, transient and collapsing process. At the full-scale level, the e-nose indicator could provide the warning of the major disturbance whereas two slight disturbances were not detected and it gave one major false alarm. This work showed that gas phase relation with anaerobic process should be deeper investigated, as an e-nose could indicate the reactor state, focusing on the gas phase. [less ▲]

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See detailBasin-scale partitioning of Greenland ice sheet mass balance components (2007–2011)
Andersen, M.L.; Stenseng, L.; Skourup, H. et al

in Earth and Planetary Science Letters (2015), 409

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be ... [more ▼]

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be well captured by observationally-constrained climate modeling, insight into D is relatively limited. We use InSAR-derived velocities, in combination with ice thickness observations, to quantify the mass flux (F ) across a flux perimeter around the ice sheet at ∼1700 m elevation. To quantify D , we correct F for SMB , as well as changes in volume due to ice dynamics, in the area downstream of the gate. Using a 1961–1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007–2011 mean D of View the MathML source. We find a 2007–2011 mean total mass balance of View the MathML source, which is equal to a 0.73 mm yr−1 global sea level rise contribution. This mass loss is dominated by SMB, which accounts for 61% of mass loss in the basins where partitioning is possible. [less ▲]

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See detailCharacteristics of Economically Designed CUSUM and \bar{X} Control Charts
Saniga, Erwin; Davis, Darwin; Faraz, Alireza ULg et al

in Knoth, Sven; Schmid, Wolfgang (Eds.) Frontiers in Statistical Quality Control 11 (2015)

In this paper we investigate the characteristics of economic control chart designs for both Shewhart (¯X ) and CUSUM control charts. Authors in the past have made some suggestions regarding the design of ... [more ▼]

In this paper we investigate the characteristics of economic control chart designs for both Shewhart (¯X ) and CUSUM control charts. Authors in the past have made some suggestions regarding the design of these charts, where design is defined as finding the values of sample size, intersample interval and control limit (Shewhart chart) or control parameters (k and h) for the CUSUM chart. Here, we run a large number of experiments consisting of many configurations of the parameters and describe and model the results in terms of the actual economic designs. [less ▲]

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See detailSeasonal variability of meiofauna, especially harpacticoid copepods, in Posidonia oceanica macrophytodetritus accumulations
Mascart, Thibaud ULg; Lepoint, Gilles ULg; Deschoemaeker, Silke et al

in Journal of Sea Research (2015), 95

The overall aim of this study was (1) to assess the diversity and density of meiofauna taxa, especially harpacticoid copepod species, present within accumulated seagrass macrophytodetritus on unvegetated ... [more ▼]

The overall aim of this study was (1) to assess the diversity and density of meiofauna taxa, especially harpacticoid copepod species, present within accumulated seagrass macrophytodetritus on unvegetated sand patches and (2) to elucidate the community structure of detritus-associated harpacticoid copepods in relation to natural temporal variability of physico-chemical characteristics of accumulations. This was investigated in a Posidonia oceanica (L.) Delile seagrass ecosystem in the northwest Mediterranean Sea (Bay of Calvi, Corsica, 42°35’N, 8°43’E) using a triplicate macrophytodetritus core field sampling in two contrasting sites over the four seasons of 2011. Meiofauna higher taxa consisted of 50% Copepoda, which 87% belonged to the Harpacticoida order. Nematoda was the second most abundant taxa. The copepod community displayed a wide variety of morphologically similar and ecologically different species (i.e. mesopsammic, phytal, phytal-swimmers, planktonic and parasitic). The harpacticoid copepod community followed a strong seasonal pattern with highest abundances and species diversity in May-August, revealing a link with the leaf litter epiphyte primary production cycle. Aside from the important role in sheltering, housing and feeding potential of macrophytodetritus, a harpacticoid community BEST analysis demonstrated a positive correlation with habitat complexity and a negative correlation with water movements and P. oceanica leaf litter accumulation. [less ▲]

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See detailMetal matrix nanocomposite coatings for improving the usage properties of metallic materials
Mertens, Anne ULg; Lecomte-Beckers, Jacqueline ULg

Conference (2015, January)

The use of metal matrix nanocomposite is at the present time not as widespread as for their polymer-based counterparts. Yet, the addition of nanoparticles in a metallic matrix also allows to significantly ... [more ▼]

The use of metal matrix nanocomposite is at the present time not as widespread as for their polymer-based counterparts. Yet, the addition of nanoparticles in a metallic matrix also allows to significantly improve its usage properties, thus opening new and interesting prospects in terms of applications. This presentation aims at providing a broad overview of the various usage properties that can be enhanced by the addition of nanoparticles as illustrated by a number of examples taken from the scientific literature as well as from the researches carried out by the Metallic Materials Science Unit at the University of Liege. [less ▲]

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