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See detailParsimonious time series clustering using P-splines
Iorio, Carmela; Frasso, Gianluca ULg; D’Ambrosio, Antonio et al

in Expert Systems with Applications (2016)

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available ... [more ▼]

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available observations. The measured time series can also be very noisy and sparse and an appropriate model describing them can be hard to define. We propose to model the observed measurements by using P-spline smoothers and then to cluster the functional objects as summarized by the optimal spline coefficients. According to the characteristics of the observed measurements, our proposal can be combined with any suitable clustering method. In this paper we provide applications based on non-hierarchical clustering algorithms. We evaluate the accuracy and the efficiency of our proposal by simulations and by analyzing two real data examples. [less ▲]

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See detailPrevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: A Randomized Controlled Trial.
Muysoms, Filip E.; DETRY, Olivier ULg; Vierendeels, Tijl et al

in Annals of surgery (2016), 263(4), 638-645

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high ... [more ▼]

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia. METHODS: A multicenter randomized trial was conducted on patients undergoing elective abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133). In the study group, retromuscular mesh-augmented reinforcement was performed with a large-pore polypropylene mesh (Ultrapro, width 7.5 cm). The primary endpoint was the incidence of incisional hernias at 2-year follow-up. RESULTS: Between February 2009 and January 2013, 120 patients were recruited at 8 Belgian centers. Patients' characteristics at baseline were similar between groups. Operative and postoperative characteristics showed no difference in morbidity or mortality. The cumulative incidence of incisional hernias at 2-year follow-up after conventional closure was 28% (95% confidence interval [CI], 17%-41%) versus 0% (95% CI, 0%-6%) after mesh-augmented reinforcement (P < 0.0001; Fisher exact test). The estimated "freedom of incisional hernia" curves (Kaplan-Meier estimate) were significantly different across study arms (chi = 19.5, P < 0.0001; Mantel-Cox test). No adverse effect related to mesh-augmented reinforcement was observed, apart from an increased mean time to close the abdominal wall for mesh-augmented reinforcement compared with the control group: 46 minutes (SD, 18.6) versus 30 minutes (SD, 18.5), respectively (P < 0.001; Mann-Whitney U test). CONCLUSIONS: Prophylactic retromuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic aneurysm is safe and effectively prevents the development of incisional hernia during 2 years, with an additional mean operative time of 16 minutes. [less ▲]

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See detailCurrent Changes in Pubertal Timing: Revised Vision in Relation with Environmental Factors Including Endocrine Disruptors.
Parent, Anne-Simone ULg; Franssen, Delphine ULg; Fudvoye, Julie ULg et al

in Endocrine development (2016), 29

The aim of this chapter is to revise some common views on changes in pubertal timing. This revision is based on recent epidemiological findings on the clinical indicators of pubertal timing and data on ... [more ▼]

The aim of this chapter is to revise some common views on changes in pubertal timing. This revision is based on recent epidemiological findings on the clinical indicators of pubertal timing and data on environmental factor effects and underlying mechanisms. A current advancement in timing of female puberty is usually emphasized. It appears, however, that timing is also changing in males. Moreover, the changes are towards earliness for initial pubertal stages and towards lateness for final stages in both sexes. Such observations indicate the complexity of environmental influences on pubertal timing. The mechanisms of changes in pubertal timing may involve both the central neuroendocrine control and peripheral effects at tissues targeted by gonadal steroids. While sufficient energy availability is a clue to the mechanism of pubertal development, changes in the control of both energy balance and reproduction may vary under the influence of common determinants such as endocrine-disrupting chemicals (EDCs). These effects can take place right before puberty as well as much earlier, during fetal and neonatal life. Finally, environmental factors can interact with genetic factors in determining changes in pubertal timing. Therefore, the variance in pubertal timing is no longer to be considered under absolutely separate control by environmental and genetic determinants. Some recommendations are provided for evaluation of EDC impact in the management of pubertal disorders and for possible reduction of EDC exposure along the precautionary principle. [less ▲]

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See detailChapter 35: Immune Reconstitution and Tolerance
Belle, Ludovic ULg; Drobyski, William R.

in Abutalib, Syed; Parameswaran, Hari (Eds.) Clinical Manual of Blood and Bone Marrow Transplantation (2016)

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See detailHigh resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosion
Jague, Emilien; Sommer, Michael; Saby, Nicolas et al

in Soil & Tillage Research (2016), 156

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See detailCassini in situ observations of long duration magnetic reconnection in Saturn’s magnetotail
Arridge, C.S.; Eastwood, J.P.; Jackman, C.M. et al

in Nature (2016)

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See detailCompte rendu, La mise en scène des produits et des marques. Représentations,significations, publics
Duchesne, Caroline ULg

in Questions de Communication (2016), 28

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps ... [more ▼]

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps, l’évolution stratégique de la mise en scène des marques, la place symbolique occupée par celles-ci dans l’espace social et l’interpénétration grandissante des registres commerciaux et culturels présidant à leur positionnement stratégique. [less ▲]

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See detailDes fixations et des remises
Moreau, Pierre ULg

in L'instance (2016)

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See detailDe l’audience
Moreau, Pierre ULg

in L'instance (2016)

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See detailEconomic assessment of energy storage for load shifting in Positive Energy Building
Dumont, Olivier ULg; Carmo, carolina; Georges, Emeline ULg et al

Conference (2016)

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See detailLes croyances délétères des patients lombalgiques : revue narrative de la littérature
Demoulin, Christophe ULg; Roussel, Nathalie; Marty, Marc et al

in Revue Médicale de Liège (2016), 71(1), 40-46

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See detailInstruction à l’audience d’introduction
Moreau, Pierre ULg

in L'instance (2016)

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See detailDiboson anomaly: Heavy Higgs resonance and QCD vector-like exotics
Aristizabal Sierra, Diego ULg; Vicente, Avelino; Herrero-Garcia, Juan et al

in Physical Review. D : Particles and Fields (2016), 93

The ATLAS collaboration (and also CMS) has recently reported an excess over Standard Model expectations for gauge boson pair production in the invariant mass region 1.8−2.2 TeV. In the light of these ... [more ▼]

The ATLAS collaboration (and also CMS) has recently reported an excess over Standard Model expectations for gauge boson pair production in the invariant mass region 1.8−2.2 TeV. In the light of these results, we argue that such signal might be the first manifestation of the production and further decay of a heavy CP-even Higgs resulting from a type-I Two Higgs Doublet Model. We demonstrate that in the presence of colored vector-like fermions, its gluon fusion production cross section is strongly enhanced, with the enhancement depending on the color representation of the new fermion states. Our findings show that barring the color triplet case, any QCD "exotic" representation can fit the ATLAS result in fairly large portions of the parameter space. We have found that if the diboson excess is confirmed and this mechanism is indeed responsible for it, then the LHC Run-2 should find: (i) a CP-odd scalar with mass below ∼2.3 TeV, (ii) new colored states with masses below ∼2 TeV, (iii) no statistically significant diboson events in the W±Z channel, (iv) events in the triboson channels W±W∓Z and ZZZ with invariant mass amounting to the mass of the CP-odd scalar. [less ▲]

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See detailCore Outcome Measure Index for low back patients: do we miss anxiety and depression?
Cedraschi, C; Marty, M; Courvoisier, DS et al

in European Spine Journal (2016), 25

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See detailLa Vieille-Montagne (1806-1873). Innovations et mutations dans l'industrie du zinc
Peters, Arnaud ULg

Book published by Éditions de la Province de Liège (2016)

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See detailL'innovation, entre rhétorique et réalité
Peters, Arnaud ULg; Halleux, Robert ULg

Book published by En Poche (Académie-Editions) (2016)

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See detailLa communication des pièces
Moreau, Pierre ULg

in L'instance (2016)

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See detailVirtual Issue celebrating the 100th volume of the Journal of Animal Physiology and Animal Nutrition
Fascetti, A. J.; Everaert, Nadia ULg

in Journal of Animal Physiology and Animal Nutrition (2016), 100(1), 1-2

[No abstract available]

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See detailLong-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report, Volume 4 The DUNE Detectors at LBNF
Aristizabal Sierra, Diego ULg

Report (2016)

The LBNF/DUNE CDR describes the proposed physics program and technical designs at the conceptual design stage. At this stage, the design is still undergoing development and the CDR therefore presents a ... [more ▼]

The LBNF/DUNE CDR describes the proposed physics program and technical designs at the conceptual design stage. At this stage, the design is still undergoing development and the CDR therefore presents a reference design for each element as well as alternative designs that are under consideration. [less ▲]

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