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See detailCrosstalk between intracellular and extracellular signals regulating interneuron production migration and integration into the cortex
Peyre, Elise ULg; Gomes Da Silva, Carla ULg; Nguyen, Laurent ULg

in Frontiers in Cellular Neuroscience (2015)

During embryogenesis, cortical interneurons are generated by ventral progenitors located in the ganglionic eminences of the telencephalon. They travel along multiple tangential paths to populate the ... [more ▼]

During embryogenesis, cortical interneurons are generated by ventral progenitors located in the ganglionic eminences of the telencephalon. They travel along multiple tangential paths to populate the cortical wall. As they reach this structure they undergo intracortical dispersion to settle in their final destination. At the cellular level, migrating interneurons are highly polarized cells that extend and retract processes using dynamic remodeling of microtubule and actin cytoskeleton. Different levels of molecular regulation contribute to interneuron migration. These include: 1/ Extrinsic guidance cues distributed along migratory streams that are sensed and integrated by migrating interneurons; 2/ Intrinsic genetic programs driven by specific transcription factors that grant specification and set the timing of migration for different subtypes of interneurons; 3/ Adhesion molecules and cytoskeletal elements/regulators that transduce molecular signalings into coherent movement. These levels of molecular regulation must be properly integrated by interneurons to allow their migration in the cortex. The aim of this review is to summarize our current knowledge of the interplay between microenvironmental signals and cell autonomous programs that drive cortical interneuron porduction, tangential migration, and intergration in the developing cerebral cortex. [less ▲]

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See detailImpact of intensive enteral nutrition in association with corticosteroïds in the treatment of severe alcoholic hepatitis: a multicenter randomized controlled trial
Moreno, C; Trepo, E; Louvet, A et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 01

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See detailMulticenter Belgian experience of sofosbuvir (medical need program) in very difficult-to-treat HCV patients: safety and efficacy results.
Degre, D; Laleman, W; Verhelst, X et al

in Acta Gastro-Enterologica Belgica (2015, March), 78(1), 03

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See detailVeno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model
MORIMONT, Philippe ULg; GUIOT, Julien ULg; Desaive, Thomas ULg et al

in Acta Anaesthesiologica Scandinavica (2015)

BACKGROUND: Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung. However, hypercapnic acidosis resulting from ... [more ▼]

BACKGROUND: Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung. However, hypercapnic acidosis resulting from ventilation at lower tidal volume enhances pulmonary hypertension and might induce right ventricular (RV) failure. We investigated if extracorporeal veno-venous CO2 removal therapy could have beneficial effects on pulmonary circulation and RV function. METHODS: This study was performed on an experimental model of ARDS obtained in eight anaesthetized pigs connected to a volume-cycled ventilator. A micromanometer-tipped catheter was inserted into the main pulmonary artery and an admittance micromanometer-tipped catheter was inserted into the right ventricle. RV-arterial coupling was derived from RV pressure-volume loops. ARDS was obtained by repeated bronchoalveolar lavage. Protective ventilation was then achieved, and the pigs were connected to a pump-driven extracorporeal membrane oxygenator (PALP, Maquet, Germany) in order to achieve CO2 removal. RESULTS: ARDS induced severe hypercapnic acidosis. Systolic pulmonary artery pressure significantly increased from 29.6 ± 1.8 to 43.9 ± 2.0 mmHg (P < 0.001). After the PALP was started, acidosis was corrected and normocarbia was maintained despite protective ventilation. Pulmonary artery pressure significantly decreased to 31.6 ± 3.2 mmHg (P < 0.001) and RV-arterial coupling significantly improved (RV-arterial coupling index = 1.03 ± 0.33 vs. 0.55 ± 0.41, P < 0.05). CONCLUSION: Veno-venous CO2 removal therapy enabled protective ventilation while maintaining normocarbia during ARDS. CO2 removal decreased pulmonary hypertension and improved RV function. This technique may be an effective lung- and RV-protective adjunct to mechanical ventilation. [less ▲]

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See detailNumerical crashworthiness analysis of an offshore wind turbine monopile impacted by a ship
Bela, Andreea ULg; Le Sourne, Hervé; Buldgen, Loïc ULg et al

in Shenoi, R Ajit; Soares, Carlos Guedes (Eds.) Analysis and Design of Marine Structures (2015, March)

The consequences of collision events can range from minor structural damages of the supporting structure to complete collapse of the wind turbine, which may lead to disruptions of the electricity ... [more ▼]

The consequences of collision events can range from minor structural damages of the supporting structure to complete collapse of the wind turbine, which may lead to disruptions of the electricity production and, at worst, to sinking of the striking ship with probability of loss of human lives or/and pollution. For all these reasons, a collision risk analysis becomes mandatory at the pre-design stage in order to identify the collision scenarios having the greatest probabilities of occurrence, to estimate the consequences of collision events and to ensure safe operations through the wind farm service life. The goal of this paper is to outline the behavior of the monopile foundations during ship collision by performing non-linear finite element simulations. Many collision scenarios are analyzed in order to study the sensitivity of the monopile to various parameters like impact striking ship velocity, nacelle mass, wind direction, soil stiffness, vertical location of the impact point, wind orientation … The internal energy dissipated by deformation of the monopile, the crushing force and the indentation of the crushed area are compared for different situations, as well as the overall displacements of the supporting structure. [less ▲]

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See detailCharacteriation of GPR101 expression across different species
Trivellin, G; Bjelobaba, I; Daly, Adrian ULg et al

in Abstract book - ENDO 2015 (2015, March)

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See detailX-Linked acro-gigantism (X-LAG) due to microduplications of chromosome Xq26 : A new disorder and implications for acromegaly
Trivellin, G; Daly, AF; Faucz, FR et al

in Abstract book - ENDO 2015 (2015, March)

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See detailL'accoutumance à l'eau: un préalable au savoir-nager.
Mornard, Manhattan ULg; Delvaux, Anne ULg; Cloes, Marc ULg et al

in Éducation Physique et Sport (2015), (364), 16-20

Synthèse de la méthodologie et des travaux scientifiques réalisés au cours de ces dernières années par le cereki dans le domaine de l'accoutumance à l'eau.

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See detailDisease characteristics of patients with X-linked acrogigantism (X-LAG) syndrome
Daly, Adrian ULg; Lodish, MB; Trivellin, G et al

in Abstract book - ENDO 2015 (2015, March)

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See detailAn orphan GPCR may be mutated in patients with Cushing Disease
Correa, RR; Trivellin, G; Li, Y et al

in Abstract book - ENDO 2015 (2015, March)

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See detailPostface aux Nouvelles du Grand Possible et autres récits de Marcel Thiry
Durand, Pascal ULg

in Nouvelles du Grand Possible et autres récits (2015)

Nouvelle édition revue et complétée des Nouvelles du Grand Possible de Marcel Thiry (et seconde édition dans la collection patrimoniale « Espace Nord »). La Postface et les annexes bio-bibliographiques ... [more ▼]

Nouvelle édition revue et complétée des Nouvelles du Grand Possible de Marcel Thiry (et seconde édition dans la collection patrimoniale « Espace Nord »). La Postface et les annexes bio-bibliographiques ont été fortement revues et complétées pour la présente édition, enfin conforme à l'édition originale de l'oeuvre ainsi qu'aux intentions ultérieures de son auteur. [less ▲]

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See detailMultitasking abilities in persons diagnosed with schizophrenia: a new tool and cognitive model.
Laloyaux, Julien ULg; Van der Linden, Martial ULg; Laroi, Frank ULg

in Schizophrenia Bulletin (2015, March), 41(Supplement 1),

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia, and in particular during multitasking activities (Semkovska et al., 2010). Multitasking refers to ... [more ▼]

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia, and in particular during multitasking activities (Semkovska et al., 2010). Multitasking refers to activities (e.g. preparing a meal) where the person has to: (a) carry out and alternate between different tasks that vary in terms of priority, difficulty and duration; (b) define the tasks’ targets; (c) and where the person is faced with unexpected problems during the realization of these tasks (Burgess, 2000). However, the cognitive underpinnings of multitasking abilities have never been adequately explored in schizophrenia. Further, only two cognitive models exist in the literature, which are based on student (Logie et al., 2011) and neurological (Burgess et al., 2000) samples. Both of these models suggest three primary constructs: Memory, Planning and Intent. There are, however, several limitations related to the way multitasking abilities were evaluated in these studies. We thus developed a computerized real-life activity task - the Computerized Meeting Preparation Task (CPMT), which was specifically designed to take into account the multitasking nature of certain everyday life activities. Using this task, and based on previous studies (Burgess et al., 2000; Logie et al., 2011), the aim of the present study was to evaluate multitasking abilities in schizophrenia and to do so in a new cognitive model of multitasking that takes into account certain cognitive functions that are not integrated in existing models. Methods: Fifty-seven individuals with schizophrenia and 41 matched healthy controls completed the CMPT. Participants were also evaluated with a battery of cognitive tests. Results: The results suggest that the CMPT possesses good sensitivity and confirmed the three underlying constructs of multitasking (Memory, Planning and Intent), which were found to be underpinned by several cognitive functions and multitasking aspects. Conclusion: Taken together, this new cognitive model and the CMPT could be a good basis for cognitive interventions of multitasking abilities in schizophrenia. Burgess, P.W., 2000. Strategy application disorder: the role of the frontal lobes in human multitasking. Psychol Res 63, 279-288. Logie, R., et al., 2011. Multitasking: multiple, domain-specific cognitive functions in a virtual environment. Mem Cogn 39, 1561-1574. Semkovska, M. et al., 2004. Assessment of executive dysfunction during activities of daily living in schizophrenia. Schizophr Res 69, 289-300. [less ▲]

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See detailControl of plankton phenology by climate variation in a Mediterranean coastal area : results from a long-term study (1979-2011)
Goffart, Anne ULg; Collignon, Amandine ULg; Hecq, Jean-Henri ULg

Conference (2015, March)

Physical processes are known to play major roles in marine plankton succession. However, few studies have addressed the mechanisms that regulate phyto- and zooplankton phenology in a context of changing ... [more ▼]

Physical processes are known to play major roles in marine plankton succession. However, few studies have addressed the mechanisms that regulate phyto- and zooplankton phenology in a context of changing climate. Here we used a unique long-term (1979-2011) time series performed in a Mediterranean coastal area unbiased by local anthropogenic pressure (PHYTOCLY station, Bay of Calvi, Corsica) to understand how environmental forcing affects the timing, duration and magnitude of the winter-spring phyto- and zooplankton blooms. We showed that phyto- and zooplankton blooms were bottom-up controlled by the establishment of favourable abiotic conditions, i.e. nutrient replenishment by vertical mixing under specific water temperature and wind conditions, for which thresholds were defined. According to the intensity of winter characteristics, there were strong differences in both the abundance and composition of phyto- and zooplankton during the winter-spring period. Our study is consistent with the recent reports that, when occurring, diatoms peaks were added to the initial phytoplankton groups instead of replacing them. In contrast, zooplankton groups followed a replacement sequence. Based on the results provided by our time series, we show that plankton phenology in the Bay of Calvi is highly controlled by climate variation and exhibits contrasted patterns in response to different scenarios of environmental forcing. [less ▲]

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See detailDual-use controls outreach: a new method
Michel, Quentin ULg; Paile, Sylvain ULg

in WorldECR (2015), (38), 27-28

Detailed reference viewed: 27 (8 ULg)