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See detail“That’s only statistics”:Recording PPPs in national accounts
Piron, Damien ULg

Conference (2016, September 02)

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See detailNON-DERMATOPHYTE DERMATOSES MIMICKING DERMATOPHYTOSES IN HUMANS
Libon, Florence ULg; TASSOUDJI, Nazli ULg; DEZFOULIAN, Bita ULg et al

in Mycopathologia (2016)

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the ... [more ▼]

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the intertriginous regions (feet, inguinal, axillar, submammary), dermatophytic colonisations and infections manifest as whitish, slightly hyperkeratotic, pruritic and sometimes fissurated lesions. On the scalp, dermatophytic infections commonly lead to single or multiple more or less inflammatory and alopecic lesions. On the plantar and palmar aspects of the feet and hand, dermatophytosis presents as an eczema-like chronic dermatosis. Abscess-like lesions may occur due to zoophilic dermatomycosis. Dermatophytic infections of the nails reveal ill-defined whitish-yellowish colorations of the distal end or the lateral aspects of the nails, sometimes combined with partial nail embrittlement or even complete destruction. Despite the ubiquity of dermatophytic skin infections and their usually highly typical clinical features, a differential diagnosis has to be considered, in particular when treatment is not efficient or when treatment resistance occurs. This review presents the differential diagnosis in terms of frequency as well as the diagnostic methods permitting the distinction of annular, intertriginous, alopecic, palmoplantar, abscess-like and onychodystrophic lesions. [less ▲]

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See detailMerger incentives under yardstick competition: A theoretical model
Teusch, Jonas ULg

Scientific conference (2016, September 02)

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See detail"Right to shape" decisions: the closing up as new strategy to move forward with high-level radioactive wastes
Parotte, Céline ULg

Conference (2016, September 02)

Short Abstract This presentation suggests a comparison between public invited critics and their integrations in Belgian, Canadian and French institutionalized processes to highlight the different ... [more ▼]

Short Abstract This presentation suggests a comparison between public invited critics and their integrations in Belgian, Canadian and French institutionalized processes to highlight the different combinations of opening up and closing down appraisals and commitments. This comparison reveals the closing up strategy of government to move forward with nuclear wastes. Since the 90’s onwards, Canadian, Belgian and French nuclear establishment (Durant 2009) have developed several different strategies to involve the public at each constitutive steps of the siting process of nuclear wastes management. Each of them has divided the decision-making process in distinct phases to focus first on the conceptual phase (go for an option) before the operational phase (go for siting). Each country has its own dynamic managed by different actors. For example, in Canada, the nuclear waste organization (NWMO) has provided iterative and permanent experts and public consultations since 2002. In France, it is the French PTA (OPECST) and National Commission of Public Debate (CNDP) who have periodically provided punctual public consultations before every important commitment. Meanwhile in Belgium, only two important punctual debates have been provided by the nuclear waste organization (ONDRAF) and an independent foundation (FRD) and are still waiting for the “go for an option”. This presentation suggests a comparison of the public invited critics (Wynne 2007) who have accepted the invitation of nuclear wastes managers, following their integrations in three different institutionalized processes (in Belgium, in France and in Canada) and the change their integrations produced in terms of closing down and opening up appraisals and commitments (Stirling 2008). It highlights how the different governments finally chosen a closing “up” commitment in order to manage the right of public to continue to shape partially the commitment as well the right of expert to continue to develop the option (geological disposal) they support since the 70’s. Data used include a combination of theoretical and empirical materials – i.e. participatory observations of consultation processes, 90 semi-directive interviews with policy makers, nuclear waste agencies, nuclear regulators in France, Belgium and Canada and local actors such as members of local information and monitoring council (CLIS) and members of community liaison committee of four volunteer collectivities (CLC). Durant, Darrin. 2009. "Radwaste in Canada: a political economy of uncertainty." Journal of Risk Research 12 (7-8):897-919. doi: 10.1080/13669870903126127. Stirling, Andy. 2008. ""Opening Up" and "Closing Down" Power, Participation, and Pluralism in the Social Appraisal of Technology." Science, Technology & Human Values 33:262-294. Wynne, Brian. 2007. "Public participation in science and technology: performing and obscuring a political–conceptual category mistake." East Asian Science, Technology and Society 1 (1):99-110. [less ▲]

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See detailThe influence of COMT on the neural substrates of short-term memory in normal aging
Manard, Marine ULg; Salmon, Eric ULg; Collette, Fabienne ULg

Conference (2016, September 02)

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not ... [more ▼]

Working memory dopaminergic modulation is generally expressed in healthy aging by an advantage for carriers of the Met allele at behavioral and brain activity levels. However, most tasks used did not allow to easily disentangle the contribution of maintenance and manipulation processes. We explored the effect of COMT genotype on the maintenance process using a Sternberg memory task varying the amount of information presented, in young and older homozygous carriers for the Val and Met alleles of the COMT gene. Although no clear behavioral difference was observed between groups, patterns of cerebral activity indicate difficulties for Met older individuals to maintain stable representations. These results will be discussed in terms of dopaminergic contribution to stability/flexibility of cognitive processes during aging. [less ▲]

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See detailAlgumas reflexões sobre o filme literário
Badir, Sémir ULg

Scientific conference (2016, September 02)

Gostaria, nesta palestra, de referir-me à maneira como se foram tecendo, no discurso do saber, os laços entre cinema e literatura, propondo certas pistas de reflexão a fim de desatar e reatar esses laços ... [more ▼]

Gostaria, nesta palestra, de referir-me à maneira como se foram tecendo, no discurso do saber, os laços entre cinema e literatura, propondo certas pistas de reflexão a fim de desatar e reatar esses laços. Para tanto, pode ser tomada, como ponto de partida, uma resposta dada pela escritora e cineasta Marguerite Duras durante uma entrevista na televisão em 1966: "Em geral, sou contra a adaptação do romance para o cinema, principalmente dos romances clássicos. (...) Imaginemos um jovem que nunca leu Moby Dick e que o leia depois de ter visto o filme. Para ele, o filme será um estorvo, sua relação com a narrativa será forçosamente impura, desde o início. É por isso que sou contra a adaptação das obras-primas para o cinema. Ela destrói, afasta, corrompe o fenômeno da leitura, que é um fenômeno importantíssimo, quando não o mais importante". [less ▲]

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See detailMacro- and near-mesoporous monoliths by medium internal phase emulsion polymerization: a systematic study
Mathieu, Kevin ULg; Jérôme, Christine ULg; Debuigne, Antoine ULg

in Polymer (2016), 99

The synthesis of a series of poly(ethylene oxide)-b-polystyrene copolymers with different block lengths was performed by radical addition fragmentation chain transfer. These amphiphilic copolymers were ... [more ▼]

The synthesis of a series of poly(ethylene oxide)-b-polystyrene copolymers with different block lengths was performed by radical addition fragmentation chain transfer. These amphiphilic copolymers were tested as stabilizers for water-in-oil medium internal phase emulsion (MIPE) templating polymerization and the formation of polyMIPEs with controlled morphology. Aside from the structure of the emulsion stabilizer, several parameters susceptible to influence the size of the cavities and the interconnectivity of the porous monoliths were probed including the choice of the comonomers, treatment of the emulsion by ultrasound, the use of controlled radical polymerization method for the network formation as well as interfacial initiation. Interconnected cellular monoliths were produced. The polymerization of the ultrasonicated water-in-ethylhexylacrylate/divinylbenzene MIPE notably led to near-mesoporous open-cell material. Mechanical properties and specific surface areas of the polyMIPEs were also investigated and discussed. [less ▲]

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See detailLe potentiel des blogues et des réseaux numériques dans l'apprentissage d'une langue étrangère
Vintila, Elena-Georgiana ULg

Conference (2016, September 02)

We selected two French foreign language textbooks published in Romania under the Ministry of Education in 2004 and 2005 by the same publishing house and we will analyze the modality of presentation of ... [more ▼]

We selected two French foreign language textbooks published in Romania under the Ministry of Education in 2004 and 2005 by the same publishing house and we will analyze the modality of presentation of grammar points offered by textbooks and selected blogs. For this analysis, we will focus on: the appearance of textbooks, respectively blogs, the presentation of the grammar point set analysis, types and number of exercises. In addition, we will try to see what socio-cultural values ​​are highlighted by the authors and how bloggers alter through publications. [less ▲]

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See detailImpact of high-wheat bran diet on sows’ microbiota, performances and progeny’s growth and health
Leblois, Julie ULg; Bindelle, Jérôme ULg; Dehareng, Frédéric et al

Conference (2016, September 02)

Finding alternatives to antimicrobial growth promoters is part of the goal of improving sustainability in pig production. Dietary fibres are considered as health-promoting substances acting on pigs’ ... [more ▼]

Finding alternatives to antimicrobial growth promoters is part of the goal of improving sustainability in pig production. Dietary fibres are considered as health-promoting substances acting on pigs’ microbiota. This study aimed to investigate whether the enrichment of sows’ diet with high levels of wheat bran (WB) could impact the performances of sows and piglets’ health. Seven sows were fed a control diet (CON) and 8 sows a WB diet from day 43 of gestation (WB 240 g/kg DM) until the end of the lactation period (WB 140 g/kg DM). Diets were formulated to be iso-energetic and iso-nitrogenous by changing the proportions of some ingredients. Faeces were sampled at different time points (before treatment, during treatment: in gestation and lactation) to determine microbiota composition (sequencing with Illumina MiSeq). Milk was sampled weekly to determine lactose, fat and protein concentration by mid-infrared technology and IgA and IgG contents by ELISA. Before weaning (d26-27), piglets were euthanized, intestinal contents and tissues sampled for further analyses. Zootechnical performances of sows and piglets were recorded. Statistical analyses were performed using the SAS MIXED procedure and repeated measurements. Treatment never impacted piglets’ weight (P=0.51). Sows’ ingestion during the lactation period was comparable between both treatments until the last 4 days of lactation where the percentage of target ingestion was significantly (P<0.001) lower for the WB (66%) compared to the CON group (89%). No effect on sows’ backfat and weight changes was observed. An increased abundance of Lactobacillus spp. in feces of the WB group was observed in gestation before and after diet change (8.8% vs 15.1% of total bacteria). However, for the overall genera changes between treatments, it only seems to occur for minor groups of bacteria. Milk protein, fat, IgG and IgA were not affected by treatment, but a time-effect (P<0.001) was observed while treatment impacted (P<0.05) lactose content. In conclusion, sows’ performances were not affected by the high WB diet and more research on the piglets’ samples is foreseen. [less ▲]

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See detailActivation de la coagulation par la Transition Epithélio-Mésenchymateuse: impact sur la colonisation métastatique
Bourcy, Morgane ULg

Doctoral thesis (2016)

Au cours de la cascade métastatique, des cellules tumorales quittent la tumeur primaire et envahissent le sang (Cellules Tumorales Circulantes, CTCs) pour former des métastases dans des organes ... [more ▼]

Au cours de la cascade métastatique, des cellules tumorales quittent la tumeur primaire et envahissent le sang (Cellules Tumorales Circulantes, CTCs) pour former des métastases dans des organes secondaires. Le processus métastatique est hautement sélectif et seule une faible proportion de CTCs survit dans la circulation et colonise les sites secondaires pour former des métastases. Les cellules tumorales subissent des changements phénotypiques qui leur procurent des propriétés migratoires et invasives ainsi que des capacités de survie accrue leur permettant de franchir ces différentes étapes. A ce jour, il est largement accepté que les processus de Transition Epithélio-Mésenchymateuse (TEM) sont impliqués dans cette plasticité cellulaire et participent à la libération et à la biologie des CTCs. Des données de la littérature indépendantes ainsi que des résultats du laboratoire suggèrent, par ailleurs, que les processus de coagulation pourraient favoriser les étapes précoces de la dissémination métastatique (survie, persistance, arrêt et extravasation). Au cours de ce travail de doctorat, nous avons examiné l’acquisition potentielle de propriétés pro-coagulantes par les CTCs dérivées d’une TEM impliquant l’expression du Facteur Tissulaire (FT), l’initiateur cellulaire clé de la cascade de coagulation. De telles propriétés coagulantes permettraient la formation d’une matrice de fibrine protectrice autour des CTCs favorisant, ainsi, leur survie dans la circulation sanguine et la colonisation métastatique. A l’aide de divers modèles cellulaires in vitro, nous avons montré que les processus de TEM sont associés à une expression accrue du FT et à des propriétés pro-coagulantes. Ensuite, nous avons fonctionnellement lié les processus de TEM à ces régulations en y impliquant des facteurs de transcription de la TEM, ZEB1 et Snail. De plus, en utilisant des modèles de métastases expérimentales, nous avons montré que l’axe TEM/FT/coagulation procure aux CTCs des propriétés de survie et des capacités de colonisation métastatique accrues. Enfin, nous avons apporté une validation clinique à ces résultats en observant des CTCs positives pour le FT et la vimentine, un marqueur mésenchymateux, dans le sang de patientes atteintes d’un cancer du sein métastatique. L’ensemble de nos résultats met en évidence un nouvel axe de régulation TEM/FT permettant une activation locale de la coagulation par les CTCs TEM+ favorisant la colonisation métastatique précoce. [less ▲]

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See detailLa voix de l'enseignant
Remacle, Angélique ULg

Conference given outside the academic context (2016)

Cette formation sur la voix destinée aux enseignants se veut théorique et pratique. Elle aborde les points suivants: 1) les bases d'anatomie et principes de fonctionnement de la voix, 2) les ... [more ▼]

Cette formation sur la voix destinée aux enseignants se veut théorique et pratique. Elle aborde les points suivants: 1) les bases d'anatomie et principes de fonctionnement de la voix, 2) les professionnels de la voix, 3) que faire quand la voix dysfonctionne, et 4) comment optimiser la voix? [less ▲]

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See detailChaotic Bohmian trajectories for stationary states
Cesa, Alexandre ULg; Martin, John ULg; Struyve, Ward

in Journal of Physics A: Mathematical and Theoretical (2016), 49

In Bohmian mechanics, the nodes of the wave function play an important role in the generation of chaos. However, so far, most of the attention has been on moving nodes; little is known about the ... [more ▼]

In Bohmian mechanics, the nodes of the wave function play an important role in the generation of chaos. However, so far, most of the attention has been on moving nodes; little is known about the possibility of chaos in the case of stationary nodes. We address this question by considering stationary states, which provide the simplest examples of wave functions with stationary nodes. We provide examples of stationary wave functions for which there is chaos, as demonstrated by numerical computations, for one particle moving in 3 spatial dimensions and for two and three entangled particles in two dimensions. Our conclusion is that the motion of the nodes is not necessary for the generation of chaos. What is important is the overall complexity of the wave function. That is, if the wave function, or rather its phase, has complex spatial variations, it will lead to complex Bohmian trajectories and hence to chaos. Another aspect of our work concerns the average Lyapunov exponent, which quantifies the overall amount of chaos. Since it is very hard to evaluate the average Lyapunov exponent analytically, which is often computed numerically, it is useful to have simple quantities that agree well with the average Lyapunov exponent. We investigate possible correlations with quantities such as the participation ratio and different measures of entanglement, for different systems and different families of stationary wave functions. We find that these quantities often tend to correlate to the amount of chaos. However, the correlation is not perfect, because, in particular, these measures do not depend on the form of the basis states used to expand the wave function, while the amount of chaos does. [less ▲]

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See detailSuccessional trajectories of cyanobacterial communities following glacier retreat in Svalbard (High Arctic)
Stelmach Pessi, Igor ULg; Pushkareva, Ekaterina; Borderie, Fabien ULg et al

Conference (2016, September 01)

The effects of global warming are pronounced at high northern latitudes, where the warming trend observed for the past decades is almost twice as the global average. Most glaciers in Svalbard (High Arctic ... [more ▼]

The effects of global warming are pronounced at high northern latitudes, where the warming trend observed for the past decades is almost twice as the global average. Most glaciers in Svalbard (High Arctic) have been retreating and thinning since the end of the Little Ice Age in the late 19th century, and retreat rates have increased substantially in the last decades. As a glacier retreats, it systematically exposes new terrestrial habitats for the colonization by pioneering (micro)organisms. Distance from the glacier terminus can be used as a proxy for time since deglaciation, which makes glacier forefields well suited for the study of primary succession. In the present study, we investigated the successional trajectories of cyanobacterial communities along a 100-year deglaciation gradient in the forefield of two Svalbard glaciers (Ebba- and Hørbyebreen). Cyanobacterial abundance was assessed by epifluorescence microscopy and cyanobacterial diversity was investigated by pyrosequencing of partial 16S rRNA gene sequences. Filamentous cyanobacteria were more abundant than unicellular and heterocystous cyanobacteria in both forefields, and an increase in the abundance of cyanobacteria was observed along the deglaciation gradients. Pseudanabaenales was the most OTU-rich order, followed by Chroococcales, Oscillatoriales, Synechococcales, Nostocales and Gloeobacterales. At the genus level, classified phylotypes were assigned to Leptolyngbya, Phormidium, Nostoc, Pseudanabaena, Chroococcidiopsis and Microcoleus. Interestingly, OTU richness increased along the deglaciation gradient in Ebbabreen, but an inverse correlation was observed in Hørbyebreen. Beta diversity estimations indicated contrasting cyanobacterial phylogenetic structures along the temporal gradient, with a clear separation of initial (10-20 years), intermediate (30-50) and advanced (80-100) communities. Time since deglaciation accounted for around 25% of the phylogenetic variability in both forefields, with organic carbon content also explaining a significant proportion of community turnover along the deglaciation gradients. Taxonomic composition was somewhat constant along the deglaciation gradient, but OTUs associated with initial communities were related to sequences predominantely restricted to polar biotopes, while advanced communities included phylotypes related to cosmopolitan taxa. [less ▲]

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See detailTEACHING VETERINARY RADIOLOGY: DOES COMPARISON HELP?
Etienne, Anne-Laure ULg; Delguste, Catherine ULg; Busoni, Valeria ULg

Poster (2016, September 01)

Introduction/Purpose Comparison learning is an approach for learning complex visual tasks. As described in human medicine, by comparing radiographs with pathology and without pathology, veterinary ... [more ▼]

Introduction/Purpose Comparison learning is an approach for learning complex visual tasks. As described in human medicine, by comparing radiographs with pathology and without pathology, veterinary students could learn to discriminate relevant disease-related information to recognize the disease. We hypothesized that exposure to a training by side-by-side comparison of normal to abnormal radiographs would lead to higher visual diagnostic accuracy and possibly to a higher ability to describe the features of a known disease on canine thoracic radiographs. Material and methods Twenty veterinary students were randomly assigned to either a group that compared radiographs showing thoracic disease with normal images (group 1) or to a group that only studied abnormal radiographs (group 2). All students had their theoretical radiology teaching and 13 of them had also received the practical teaching of the study curriculum, evenly distributed between the 2 groups. Twenty-nine radiographs of small animal thorax were used. The procedure consisted in three experimenter-supervised phases: 1. training, 2. visual recognition test, 3. feature description test. In the training phase, each screen showed two radiographs with the name of the disease present in each. In the group 1 (pathology/normal condition), a radiograph of a patient and a normal image were shown next to each other. In the group 2 (pathology/pathology condition), two radiographs of patients with the same disease were shown next to each other. The 9 screens were presented twice, with the diseases in a different order for the first and second runs. A Mann-Whitney test was used to compare the success rates of groups of students. Results On visual recognition test, there was no statistical difference in visual diagnostic accuracy between groups. When students gave the wrong answer, they often diagnosed the item as another disease of similar distribution (diffuse or focal). Students who received the practical teaching and students of group 1 had a higher accuracy for normal thoracic radiographs. On feature description test, no significant effect of comparison learning was found, but focal diseases were better described than diffuse diseases with a significant difference between these. Discussion/Conclusions Results show that comparison with normal images did not help in recognizing or describing thoracic pathologies but helps to recognize normal images. [less ▲]

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See detailHow to expand method by and for sensory: trials along and beside fieldwork
Vangeebergen, Thomas ULg

Conference (2016, September 01)

In a research with sensory analysts and flavourists, I tried other ways of interview (e.g. people auto-confrontations to their own registered activity) and other mediums to relate to the ethnographical ... [more ▼]

In a research with sensory analysts and flavourists, I tried other ways of interview (e.g. people auto-confrontations to their own registered activity) and other mediums to relate to the ethnographical work, as graphic novel or comics. [less ▲]

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See detailComputed tomographic findings of a far lateral lumbar disc extrusion in a dog
Rizza, Maïlis ULg; Bouvy, Bernard ULg; Shimizu, Naomi ULg et al

Poster (2016, September 01)

Introduction In human medicine, far lateral lumbar disc extrusion (FLLDE) represents 7 to 12% of all disc herniations and MRI is the method of choice for diagnosis. MRI findings of a FLLDE has been ... [more ▼]

Introduction In human medicine, far lateral lumbar disc extrusion (FLLDE) represents 7 to 12% of all disc herniations and MRI is the method of choice for diagnosis. MRI findings of a FLLDE has been reported in one dog and the aim of this case report is to describe computed tomographic (CT) findings of a FLLDE in a dog. Methods A six-year-old neutered female Beagle with a good general health status was presented with a month history of left hind limb pain with shivering of this limb. Clinical examination revealed a left hind proprioceptive deficit but no pain was elicited at palpation. Results A CT scan pre- and post- contrast studies of the lumbosacral spine and a myelographic-CT were performed. A 1.3x0.6x0.3 cm homogeneous hyperattenuating (+/- 350 HU) ovoid structure was observed at the left lateral aspect of L6-L7 intervertebral disc space. The L6-L7 intervertebral disc nucleus pulposus was calcified but the annulus fibrosus had a normal non-calcified attenuation and seemed intact apart from a very thin hyperattenuating line next to the ovoid structure. This change was well circumscribed by an even hyperattenuating rim (1000HU) mimicking a thin dense cortex and was in close proximity with the annulus fibrosus and the left transverse process of L7. Perineural fat was not observed and contrast enhancement was visualized at the level of the left sixth lumbar nerve root with impingement and thickening of this root. No compression of the spinal cord was observed at this level on the myeloCT. These findings were suggestive of a dystrophic mineralization or an osteochondromatosis. FLLDE was considered less likely because of the almost normal appearance of the annulus fibrosus. At surgery some mixed gelified calcified material consistent with disc material was removed at the level of the left L6-L7 nerve root tract and disc fenestration was performed. The histological analysis confirmed the presence of degenerated herniated vertebral disk. Discussion/Conclusions In human medicine, MRI and CT scan are the main diagnostic modalities employed for diagnosis of FLLDE. In veterinary medicine, CT is often used to assess spinal diseases because of its availability. To the authors’ knowledge, CT findings of a FLLDE have not been described previously in dogs. Moreover, the thin dense cortex appearance surrounding the disc material was surprising. In conclusion, FLLDE should be included in the differential diagnosis of a calcified ovoid structure lateral to the spine even if the annulus fibrosus appears normal and if this structure is in close relation with the vertebral transverse process. [less ▲]

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See detailComputed tomography-guided injection of muscle-derived mesenchimal stem cells in the intervertebral disc of dogs affected by natural disc degeneration: clinical safety and intervertebral disc imaging assessment
Liotta, Annalisa Pia ULg; Sandersen, Charlotte ULg; Ceusters, Justine ULg et al

Poster (2016, September 01)

Introduction/Purpose: Pre-clinical randomized controlled animal trials have been conducted to evaluate the effects of mesenchymal stem cell (MSCs) transplantation on intervertebral disc (IVD) degeneration ... [more ▼]

Introduction/Purpose: Pre-clinical randomized controlled animal trials have been conducted to evaluate the effects of mesenchymal stem cell (MSCs) transplantation on intervertebral disc (IVD) degeneration. According to their histological results and to imaging assessment of the IVD, intradiscal injection of MSCs is effective, arresting or slowing IVDD process, and is associated with a low complication rate. Few of these studies have been conducted on canine artificially degenerated IVD, using bone marrow or adipose-derived MSCs. Therefore a systematic study on naturally degenerated IVD using MSCs obtained from autologous muscular tissue in dogs is still lacking. The aims of this study were to evaluate the clinical effects of intradiscal injection of muscle-derived MSCs and its effects on imaging features of the intervertebral disc. Methods: Eight experimental dogs were randomly included with the approval of the University’s Animal Care and Use Committee. The final inclusion criteria were the presence of naturally degenerated lumbosacral IVD detected on low-field magnetic resonance (MRI) images and the obtaining of 3 x 106 autologous muscle-derived MSCs. A computed tomography (CT) and MRI examination was performed before and 2 months after the procedure and 13 imaging parameters were assessed. Mesenchymal stem cells diluted in 0,2 ml of FRS Hypothermosol were injected in the lumbosacral IVD under CT-guidance. Clinical examinations were performed regularly during 1 month after the procedure. Results: Six dogs met the inclusion criteria. The remaining 2 dogs did not undergo intradiscal injections, but were used as control group. No major or minor complications were reported during the procedure. No abnormalities were noticed during the clinical examinations. No statistically significant variations of IVD imaging features were noticed before and after the injections. Discussion/Conclusions: Intradiscal injection of muscle-derived MSCs is clinically safe and it is not associated with any progression of the IVD degeneration, detected by CT or low-field MRI imaging. Further studies are needed to assess its efficacy as treatment for the canine natural IVD degeneration. [less ▲]

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