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See detailFrom Metabolomics to Identification of a new therapeutic approach for Age-Related Macular Degeneration (AMD)
Schoumacher, Matthieu ULg; De Tullio, Pascal ULg; LAMBERT, Vincent ULg et al

Poster (2016, May)

Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world among people aged 50 or older. 90% of all vision loss due to AMD result from the exudative form, which is ... [more ▼]

Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world among people aged 50 or older. 90% of all vision loss due to AMD result from the exudative form, which is characterized by choroidal neovascularization (CNV). Age-related changes that induce pathologic CNV are incompletely understood and critical issues remain to be addressed. Metabolomics is defined as the comprehensive study of endogenous metabolites changes in various biological systems. This newly emerging “omic” science provides a unique opportunity to correlate variation of the metabolome with pathological occurrence or progression and/or to identify metabolites that are implicated in the disease. We apply a 1H NMR metabolomics approach on sera collected from AMD patient and healthy volunteers and form a mice model of laser-induced CNV which mimics the effect of exudative AMD. After post-processing treatments, the different spectra were analyzed by statistical discriminant methodologies (PCA, ICA, PLS-DA, O-PLS-DA). These approaches allow the differentiation between control and AMD patients and between laser-induced mice and the control mice group. Moreover, the same discriminating spectral zones have been identified in human and mice model, leading to the emergence of different putative biomarkers. Among these markers, lactate emerges as a key metabolite in both settings. Mechanistically, lactate produced locally and by inflammatory cells, plays a critical role in the onset of the inflammatory and angiogenic phases. In mice model of laser-induced CNV, normalization of circulating lactate by dichloroacetate a pyruvate dehydrogenase kinase (PDK) inhibitor, decreases CNV development. Our data support the innovative concept of lactate as a parainflammation- and angio-metabolite associated to AMD and CNV progression. Moreover, control of blood lactate level via inhibition of PDK provides new options for the treatment of exudative AMD. This study demonstrates the ability of metabolomics for drug target discovery and opens new perspectives for AMD treatment and patient follow-up. [less ▲]

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See detailImaging air volume fraction in sea ice using non-destructive X-ray tomography
Crabeck, O; Galley, R.J.; Delille, Bruno ULg et al

in Cryosphere (The) (2016), 10

Although the presence of a gas phase in sea ice creates the potential for gas exchange with the atmosphere, the distribution of gas bubbles and transport of gases within the sea ice are still poorly ... [more ▼]

Although the presence of a gas phase in sea ice creates the potential for gas exchange with the atmosphere, the distribution of gas bubbles and transport of gases within the sea ice are still poorly understood. Currently no straightforward technique exists to measure the vertical distribution of air volume fraction in sea ice. Here, we present a new fast and non-destructive X-ray computed tomography technique to quantify the air volume fraction and produce separate images of air volume inclusions in sea ice. The technique was performed on relatively thin (4–22 cm) sea ice collected from an experimental ice tank. While most of the internal layers showed air volume fractions <2 %, the ice–air interface (top 2 cm) systematically showed values up to 5 %. We suggest that the air volume fraction is a function of both the bulk ice gas saturation factor and the brine volume fraction. We differentiate micro bubbles (Ø<1 mm), large bubbles (1mm<Ø<5 mm) and macro bubbles (Ø>5 mm). While micro bubbles were the most abundant type of gas bubbles, most of the air porosity observed resulted from the presence of large and macro bubbles. The ice texture (granular and columnar) as well as the permeability state of ice are important factors controlling the air volume fraction. The technique developed is suited for studies related to gas transport and bubble migration. [less ▲]

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See detailElectromagnetic Investigation of the Pb-Zn deposit of Lontzen, Belgium
Evrard, Maxime ULg; Pirard, Eric ULg; Nguyen, Frédéric ULg

in First International Conference: MINING IN EUROPE, ABTSRACT volume (2016, May)

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See detailPRODUCTION OF BIOFUELS AND BIOBASED COMPOUNDS IN URBAN BIOREFINERIES: A STRATEGY TO MANAGE WASTE IN WALLONIA?
Richel, Aurore ULg; Haubruge, Eric ULg; Jacquet, Nicolas ULg

Conference (2016, May)

“Urban biorefining” is an original concept aiming at using urban wastes (household wastes, municipal wastes, industrial liquid and/or solid residues and side-products, etc.), mainly of vegetal origin, for ... [more ▼]

“Urban biorefining” is an original concept aiming at using urban wastes (household wastes, municipal wastes, industrial liquid and/or solid residues and side-products, etc.), mainly of vegetal origin, for the production of an array of biofuels and bioproducts. This “urban biorefining” concept fits particularly with the economic, geographic and politic contexts and constraints of the Walloon Region (south part of Belgium). Indeed, Walloon Region is a very small territory (area of about 6,504 sq mi) with a temperate climate. Supply feedstock, mainly arising form forestry and agriculture, are thus rather restricted, submitted to importation, and subjected to non-standardized quality. Several examples of our regional strategy, still available on an industrial scale, are herein proposed and detailed. [less ▲]

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See detailGarric (Henri), dir., L’Engendrement des images en bande dessinée
Crucifix, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2016), (48), 172-174

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See detailAtypical myopathy: an update
Votion, Dominique ULg

in In Practice (2016), 38(5), 241-246

This article gives an overview of atypical myopathy, discussing the mechanism involved, its aetiology and the clinical signs and management (therapeutic and prevention).

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See detailRapport d'activité semestriel n°3
Legrand, Catherine ULg; Henrotin, Yves ULg

Report (2016)

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See detailDélinquance et désistance : quelle méthodologie de recherche ?
Puglia, Rosa ULg; Glowacz, Fabienne ULg

Conference (2016, May)

Dans la littérature concernant la délinquance, les auteurs se sont, au départ, principalement intéressés aux raisons qui poussent les individus à commettre des délits mais peu ont tenté de comprendre ... [more ▼]

Dans la littérature concernant la délinquance, les auteurs se sont, au départ, principalement intéressés aux raisons qui poussent les individus à commettre des délits mais peu ont tenté de comprendre pourquoi et comment certains individus, qui ont commis des actes délictueux, sortent de la délinquance. En effet, la désistance, c’est-à-dire le processus de sortie de la délinquance, a longtemps été négligée par les chercheurs. À partir des années '50, un intérêt croissant pour ce domaine de recherche apparaît. La désistance devient alors un sujet d’étude indépendant et non plus un appendice de la recherche sur les carrières délinquantes (Mohammed, 2012). Malgré l’intérêt croissant pour ce champ de recherche, de nombreuses zones d’ombre persistent. Sur base d’une recherche longitudinale réalisée sur une population d’adultes en émergence délinquants (17-25ans), nous tentons d’avoir une approche holistique de la désistance. Celle-ci est définie ici comme un processus impliquant des changements individuels et sociaux, qui s’inscrit dans le temps et qui peut être marqué par des réitérations d’actes délinquants. Dans notre étude, la désistance sera étudiée à travers une approche mixte combinant un récit de vie et des questionnaires. L’approche narrative est essentielle dans notre recherche, elle permettra d’appréhender les transformations identitaires, les schémas de changement et de stabilité dans le parcours de vie et dans la trajectoire délinquante. Elle permettra également de mettre en avant les facteurs internes et externes identifiés comme des facteurs de désistance. Par ailleurs, comme Maruna (2001), nous posons l’hypothèse que les persistants et les désistants sont des individus similaires qui se trouvent à des stades différents du processus de changement. C’est pourquoi, en toile de fond, la désistance sera envisagée à travers le modèle transthéorique de Proshaska et DiClemente (1982) où différentes étapes se succèdent avant l’arrêt du comportement problématique. [less ▲]

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See detailRecrutement et réseaux des représentants diplomatiques belges auprès du royaume d'Italie (1861-1911)
Genin, Vincent ULg

in Michel Dumoulin, Catherine Lanneau (Ed.) La biographie individuelle et collective dans le champ des relations internationales (2016)

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See detailGarth St Omer, Prisnms
Mascoli, Giulia ULg; Willie, Malica S.

Article for general public (2016)

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See detailInsights into a million-year-scale Rhenohercynian carbonate platform evolution through a multi-disciplinary approach: example of a GIvetian carbonate record from Belgium
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Devleeschouwer, Xavier et al

in Geological Magazine (2016)

In this paper we formulate answers to three important questions related to Givetian carbonate records and their use for reconstructing million-year past palaeoenvironmental changes. First, we provide ... [more ▼]

In this paper we formulate answers to three important questions related to Givetian carbonate records and their use for reconstructing million-year past palaeoenvironmental changes. First, we provide detailed illustrations of the fascinating diversity that shaped a significant shallow reefal platform during the early- to late-Givetian in the Rhenohercynian Ocean; secondly we improve the sedimentological model of the extensive Givetian carbonate platform in the Dinant Basin and thirdly we evaluate the application of magnetic susceptibility (MS) as a tool for long-term trend correlations and palaeoenvironmental reconstructions. These goals are reached by making sedimentological, geophysical and geochemical study of the La Thure section. Through the early-late Givetian interval we discerned eighteen microfacies ranging from a homoclinal ramp to a discontinuously rimmed shelf and then a drowning shelf. The comparison of these sedimentological results with those published in the south of the Dinant Syncline allowed us to provide an up to date model of the vertical and lateral environmental development for one of the largest Givetian carbonate platforms in Europe. This comparison also increased the knowledge on the facies belts distribution into the Dinant Basin and allowed us to highlight the Taghanic Event. Palaeo-redox proxies reveal a substantial change in the oxygenation level, from oxygen-depleted to more oxic condition, between middle and late Givetian. We demonstrated the relationship between variation in MS values and proxies for siliciclastic input (such as Si, Al). The La Thure is considered as a key section for the understanding of internal shelf settings bordering Laurussia’s south-eastern margin. [less ▲]

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See detailChronique. Droit pénal européen.
Flore, Daniel ULg; Bosly, Stéphanie

in Journal de Droit Européen [=JDE] (2016)

Chronique annuelle présentant les évolutions du droit pénal européen (de l'UE) pour la période du 1er mars 2015 au 29 février 2016 : nouveaux instruments normatifs et développements jurisprudentiels.

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See detailJIMMY JOHNSON - Bluesman majeur en mode mineur
Sacré, Robert ULg

in ABS Magazine (2016), (50), 36-48

Dossier : interview et biographie ; avec photos

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See detailJeunes fugueurs en Belgique : Indicateurs de risque et de protection dans les signalements
Courtain, Audrey ULg; Glowacz, Fabienne ULg

Conference (2016, May)

Chaque année, 1% des foyers européens vit la fugue d’un de ses membres de moins de 18 ans. Au 2 janvier 2014, plus de onze mille jeunes français étaient recherchés comme fugueurs ; avec près de 50.000 ... [more ▼]

Chaque année, 1% des foyers européens vit la fugue d’un de ses membres de moins de 18 ans. Au 2 janvier 2014, plus de onze mille jeunes français étaient recherchés comme fugueurs ; avec près de 50.000 fugues de mineurs français par an. En Belgique, sur les années 2013-2014, l’organisme Child Focus s’est vu confier près de 1700 dossiers de fugues de mineurs. Child Focus - Fondation pour Enfants Disparus et Sexuellement Exploités – a été créée à la suite de l’affaire Dutroux, et traite des dossiers de disparitions de mineurs (enlèvements par un tiers, enlèvements parentaux, fugues) et d’exploitation sexuelle de mineurs. Généralement contacté par la famille du jeune ou par la police, Child Focus ne peut ouvrir un dossier de fugue qu’à la suite d’un procès-verbal. Les dossiers de fugues de mineurs ouverts auprès de Child Focus constitueraient un cinquième des fugues enregistrées par la police belge. Ces dossiers, de par leur contenu, permettent d’envisager trois axes de recherche. Le premier axe porte sur le profil des jeunes signalés en fugue (âge, sexe, contexte familial, scolarité,…). Le second axe porte sur le profil du signalant (père, mère, famille élargie, police,…). Le troisième axe porte sur les indicateurs de risque et de protection que les signalants expriment auprès de Child Focus lorsqu’ils évoquent le jeune en fugue (consommation de drogue, délinquance, santé mentale,…). Ces trois axes sont étudiés à partir de deux recherches empiriques, la première portant sur les 1700 dossiers des années 2013-2014, et la seconde portant sur 200 de ces dossiers, dont nous donnerons les résultats préliminaires. Enfin, par ces recherches, nous proposons d’évaluer la portée des filtres et de la black box permettant de comprendre comment et pourquoi certains cas de fugue sont davantage susceptibles d’être confiés à Child Focus que d’autres. [less ▲]

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See detailMicroplastics contamination in three planktivorous and commercial fish species
Collard, France ULg; Das, Krishna ULg; Gilbert, Bernard ULg et al

Poster (2016, May)

In 2014, 311 million tonnes of plastics were produced worldwide while it is estimated that 10% ended up in the oceans. Plastics adsorb many pollutants, cause entanglements in many vertebrates and provoke ... [more ▼]

In 2014, 311 million tonnes of plastics were produced worldwide while it is estimated that 10% ended up in the oceans. Plastics adsorb many pollutants, cause entanglements in many vertebrates and provoke blockage of the digestive tract of marine mammals, birds and turtles. Plastics also fragment in smaller parts, forming microplastics (<5 mm). These microplastics have the same size than planktonic organisms and can thus be ingested by filter-feeders and planktivorous organisms including fish. Although planktivorous Clupeiforme species are the most fished species in the world (17 million tonnes in 2013), the possible impact of microplastic ingestion on this group has received little attention. The aim of this study was to quantify and to characterize the ingested anthropogenic particles (AP) in herrings (Clupea harengus), sardines (Sardina pilchardus) and anchovies (Engraulis encrasicolus). Twenty individuals of each species were sampled. Herrings and sardines were caught in the Channel and in the North Sea in January 2013 and in January 2014. Anchovies were sampled in July 2013. The stomach contents were digested by sodium hypochlorite to isolate AP and then they were analysed by Raman spectroscopy and measured. AP were constituted of microplastics (MP) and cellulose fibres, sometimes associated with dyes. We found several plastic families: polyethylene (PE), polypropylene (PP), polystyrene, polyacrylonitrile, polyethylene terephthalate, polyamide and poly(butyl methacrylate). MP occurred in 35%, 50% and 40% of stomach contents of anchovies, sardines and herrings, respectively. Anchovies ingested bigger AP (2 mm) than the two other species. MP was in majority PE followed by PP. Our study shows that highly commercial species are exposed to MP. Further research is needed as MP are transport medium for organic pollutants and their fate once in the organism is unknown. [less ▲]

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See detailAre crop models able to efficiently simulate crop growth under shade?
Artru, Sidonie ULg; Dumont, Benjamin ULg; Lassois, Ludivine ULg et al

in Gosme, Marie (Ed.) 3rd European Agroforestry conference 2016 - Book of abstracts (2016, May)

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See detailGenetic predisposition to breast cancer occurring in a male-to-female transsexual patient
Potorac, Iulia ULg; CORMAN, Vinciane ULg; Manto, Florence et al

Poster (2016, May)

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