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See detailA vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka.
Yu, T; Graf, M; Renn, Jörg ULg et al

in Development (2017), 144(2), 265-271

Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation ... [more ▼]

Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Sp7/Osx for bone formation also in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation. [less ▲]

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See detailSchizophrénie et perspective en première personne : Essai de psychopathologie phénoménologique
Valentiny, Caroline; Englebert, Jérôme ULg

Book published by De Boeck (2017)

Comment rencontrer l’homme schizophrène dans sa singularité, dans la richesse et les difficultés de son expérience ? Comment partager l’indicible de la rupture psychotique ? Comment dépasser les ... [more ▼]

Comment rencontrer l’homme schizophrène dans sa singularité, dans la richesse et les difficultés de son expérience ? Comment partager l’indicible de la rupture psychotique ? Comment dépasser les catégorisations symptomatiques réduisant, selon une perspective en troisième personne, l’homme à sa maladie ? Les auteurs proposent une approche contemporaine et inédite de la schizophrénie. Ils s’inspirent d’un outil, l’échelle EASE, qui permet, selon une perspective en première personne, une exploration guidée de la (des) subjectivité(s) schizophrénique(s). L’échelle pose des balises dans l’investigation d’expériences liées aux troubles du soi. Elle permet de percevoir différemment la maladie, de l’intérieur, offrant ainsi une alternative rigoureuse aux approches a-subjectives des DSM-IV et 5. Située en amont de tout a priori théorique, la voie de la psychopathologie phénoménologique est une perspective originale, susceptible de nouer des dialogues féconds tant avec la psychanalyse qu’avec les sciences cognitives. Le choix d’une approche phénoménologique s’ancre dans une volonté de laisser la place à l’étonnement, de ne pas pré-penser, ou le moins possible, le recueil d’expériences. Les explorations des phénomènes décrits par les patients se nourrissent de la tradition de la psychopathologie phénoménologique (Blankenburg, Minkowski, Binswanger, Tatossian) et de ses apports contemporains (Stanghellini, Sass, Parnas, Fuchs) tout en laissant au phénomène clinique la primauté. Après une analyse approfondie du discours des patients, l’ouvrage explore l’hypothèse proposée par Louis Sass selon laquelle la folie pourrait dériver d’une intensification plutôt que d’un affaiblissement de la conscience. Les phénomènes d’hyper-réflexivité, particulièrement saillants dans les descriptions, semblent constituer des moments centraux dans leur rapport au monde. Ils se plaignent notamment d’une exacerbation de la pensée, de la recherche de sens, de l’intensité de la réflexion au détriment de la capacité d’abandon naturelle et antéprédicative au monde. Ce que les personnes schizophrènes ont à nous dire de leur expérience subjective, si l’on prend la peine de la creuser avec elles et malgré la rudesse de leur vécu, s’avère, au final, étonnant. [less ▲]

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See detailAgrégation-dispersion-empilement-monument continu
Van Rooyen, Xavier ULg

Learning material (2017)

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See detailA new, challenging benchmark for nonlinear system identification
Tiso, Paolo; Noël, Jean-Philippe ULg

in Mechanical Systems & Signal Processing (2017), 84

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by ... [more ▼]

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by challenging the community through a new benchmark structure exhibiting complex nonlinear dynamics. The proposed structure consists of two o ffset cantilevered beams connected by a highly flexible element. For increasing forcing amplitudes, the system sequentially features linear behaviour, localised nonlinearity associated with the buckling of the connecting element, and distributed nonlinearity resulting from large elastic deformations across the structure. A finite element-based code with time integration capabilities is made available at http://sem.org/TDIV-Nonlin.asp. This code permits the numerical simulation of the benchmark dynamics in response to arbitrary excitation signals. [less ▲]

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See detailA nonlinear state-space approach to hysteresis identification
Noël, Jean-Philippe ULg; Esfahani, Alireza; Kerschen, Gaëtan ULg et al

in Mechanical Systems & Signal Processing (2017), 84

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an ... [more ▼]

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an assumption may be a hard requirement to handle in real applications, since hysteresis is a highly individualistic nonlinear behaviour. The present paper adopts a black-box approach based on nonlinear state-space models to identify hysteresis dynamics. This approach is shown to provide a general framework to hysteresis identification, featuring flexibility and parsimony of representation. Nonlinear model terms are constructed as a multivariate polynomial in the state variables, and parameter estimation is performed by minimising weighted least-squares cost functions. Technical issues, including the selection of the model order and the polynomial degree, are discussed, and model validation is achieved in both broadband and sine conditions. The study is carried out numerically by exploiting synthetic data generated via the Bouc-Wen equations. [less ▲]

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See detailEffective components of interventions in juvenile justice facilities: How to take care of delinquent youths?
Mathys, Cécile ULg

in Children and Youth Services Review (2017), 73

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in ... [more ▼]

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in juvenile justice facilities. The effectiveness of remedial measures to best address the sources of youths' delinquent behaviors and the performance of juvenile justice system are discussed first, and then two theoretical frameworks of rehabilitative models are described that are commonly used with delinquent youths. Finally, specific recommendations for enhancing treatment in juvenile justice facilities with regard to the content of interventions, social climate, and youth motivation to engage in treatment are described and explained in a way intended to help caregivers and practitioners, supervisors of juvenile justice facilities, and policy makers improve the daily life of youths placed in this kind of environment. [less ▲]

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See detailLo choro oltra misura bello
Bugini, Mariaelena ULg

in Alla corte del re di Francia (2017)

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See detailNovel strategies for improving hematopoietic reconstruction after allogeneic hematopoietic stem cell transplantation or intensive chemotherapy.
Baron, Frédéric ULg; Nagler, Arnon

in Expert Opinion on Biological Therapy (2017)

INTRODUCTION: High-dose conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT) as well as intensive poly-chemotherapy for acute myeloid leukemia (AML) induce prolonged periods ... [more ▼]

INTRODUCTION: High-dose conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT) as well as intensive poly-chemotherapy for acute myeloid leukemia (AML) induce prolonged periods of neutropenia. The duration of the neutropenia is particularly long following umbilical cord blood transplantation (UCBT). Areas covered: After briefly reviewing the impact of hematopoietic growth factors administration to hasten hematologic reconstitution after allo-HCT or intensive AML chemotherapy, this article summarizes recent approaches that have been investigated to prompt hematologic reconstruction after UCBT or intensive AML chemotherapy. Expert opinion: In the allo-HCT setting, administration of G-CSF or GM-CSF shortened the duration of the neutropenia but failed to decrease infection-related mortality or to improve survival. Novel approaches to hasten hematological reconstruction after UCBT such as double UCBT with expansion of one of the 2 UCB units with Notch ligand, mesenchymal stromal cells, nicotinamide, or StemRegenin 1, co-transplanting a single UCB unit with HLA-haploidentical CD34+ cells, or increasing UCB HSC homing to marrow niches via direct intra bone UCB administration, pulse treatment with dmPGE2 or enforced fucosylation are promising and deserve further investigations in prospective phase III studies. In the AML setting, G-CSF or GM-CSF administration after intensive chemotherapy decreased the duration of the neutropenia without improving survival. [less ▲]

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See detailAnti-thymocyte globulin as graft-versus-host disease prevention in the setting of allogeneic peripheral blood stem cell transplantation: a review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Baron, Frédéric ULg; Mohty, Mohamad; Blaise, Didier et al

in Haematologica (2017)

Allogeneic hematopoietic stem cell transplantation is increasingly used as treatment for patients with life threatening blood diseases. Their curative potential is largely based on immune-mediated graft ... [more ▼]

Allogeneic hematopoietic stem cell transplantation is increasingly used as treatment for patients with life threatening blood diseases. Their curative potential is largely based on immune-mediated graft-versus-leukemia effects caused by donor T cells contained in the graft. Unfortunately, donor T cells are also the cause of graft-versus-host disease. The vast majority of HLA-matched allogeneic hematopoietic stem cell transplantations are nowadays carried out with peripheral blood stem cells (PBSC) as stem cell source. In comparison with bone marrows, PBSC contain more hematopoietic stem/progenitor cells but also one log more T cells. Consequently, the use of PBSC instead of bone marrow has been associated with faster hematological recovery and a lower risk of relapse in patients with advanced disease, but also with a higher incidence of chronic graft-versus-host disease. These observations have been the basis for several studies aimed at assessing the impact of immunoregulation with anti-thymocyte globulin (ATG) on transplantation outcomes in patients given HLA-matched PBSC from related or unrelated donors. After a brief introduction on ATG, this article reviews recent studies assessing the impact ATG on transplantation outcomes in patients given PBSC from HLA-matched related or unrelated donors as well as in recipients of grafts from HLA-haploidentical donors. [less ▲]

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See detailOn the transition between symmetric and asymmetric flow in rectangular shallow reservoirs - a case of maximum energy dissipation?
Westhoff, Martijn; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in 4th International Symposium of Shallow Flows (2017)

Shallow reservoirs are often used as sediment traps or storage basins, in which sedimentation depends on the flow pattern. Short rectangular reservoirs reveal a straight jet from inlet to outlet with ... [more ▼]

Shallow reservoirs are often used as sediment traps or storage basins, in which sedimentation depends on the flow pattern. Short rectangular reservoirs reveal a straight jet from inlet to outlet with identical recirculation zones on both sides. In longer reservoirs, the main jet reattaches to the side of the reservoir leading to small and large recirculation zones. Previous studies have found an empirical geometric relation describing the switch between these two flow patterns. In this study, we demonstrate, with a simple analytical model, that this switch coincides with a maximization of energy dissipation in the shear layer between the main jet and recirculation zones: Short reservoirs dissipate more energy when the flow pattern is symmetric, while longer reservoirs dissipate more energy with an asymmetric pattern. This approach enables the prediction of the flow patterns without detailed knowledge of small scale processes, potentially useful in the early phase of reservoir design. [less ▲]

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See detailImportance of parenteral nutrition in feeding the premature infant
SENTERRE, Thibault ULg

in International Conference for Advancing Nutrition - Neonatology, Brussels (2017)

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See detailL’ÉVALUATION DES POLITIQUES PUBLIQUES DANS LE CHAMP DE LA COOPÉRATION AU DÉVELOPPEMENT BELGE : LE CAS DU SERVICE DE L’ÉVALUATION SPÉCIALE
Contor, Justine ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017)

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation ... [more ▼]

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation Spéciale de la coopération belge au développement (SES). Nous présenterons dans ce document les raisons de la création de ce service au début des années 2000. En effet, le SES, avec d’autres acteurs, est le résultat d’une grande réforme de la coopération issue d’une lourde crise. Nous reviendrons sur son mandat, sur ses spécificités organisationnelles (ressources financières et humaines) ainsi que son cadre de référence normatif. La question de la culture évaluative sera questionnée, ainsi que son lien avec l’émergence du New Public Management dans la politique de coopération au développement. Enfin, nous questionnerons la légitimité d’une structure telle que le SES au regard d’un cadrage théorique mixte (Scott, 1995 ; Suchmann, 1995) et de la théorie des parties prenantes. [less ▲]

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See detailEvaluation d'un itinéraire clinique pour collectomie gauche en chirurgie abdominale
Mattart, Laurine; Stevens, Marie; Magis, David ULg et al

in Revue Médicale de Liège (2017), 72(1), 45-50

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne ... [more ▼]

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne nécessitant une résection du côlon gauche par laparoscopie a été incluse dans cet IC entre 2009 et 2015. Nous nous sommes intéressés à l’observance du protocole de l’IC ainsi qu’aux taux de complications et de ré-hospitalisations dans les 30 jours post-opératoires. Nous avons constaté, après comparaison avec un groupe témoin historique, que l’adhésion au protocole IC a été d’emblée excellente (> 80 %) tout au long de la durée de l’étude. Il n’y a pas eu de modification du taux de ré-hospitalisations et le taux de lâchage de suture a été réduit. Bien que la diminution de la durée de séjour n’était pas l’objectif premier lors de la mise en place de cet IC, elle s’est significativement réduite passant, en moyenne, de 8 à 4 jours. En conclusion, l’introduction d’un IC, pour autant qu’il soit bien préparé et rassemble dans le même objectif l’ensemble des acteurs de soins, est directement bénéfique pour le patient et la qualité de sa prise en charge. [less ▲]

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See detailJean d'Outremeuse et les reliques
George, Philippe ULg

in Saintuaire (2017)

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See detailAqueous sol-gel synthesis and film deposition methods for the large-scale manufacture of coated steel with self-cleaning properties
Mahy, Julien ULg; Léonard, Géraldine ULg; Pirard, Sophie ULg et al

in Journal of Sol-Gel Science and Technology (2017), 81(1), 27-35

A process has been developed to enable the large scale production of pure TiO2 films deposited on 316L stainless steel in order to get an easy-to-clean surface. This large scale process requires an easy ... [more ▼]

A process has been developed to enable the large scale production of pure TiO2 films deposited on 316L stainless steel in order to get an easy-to-clean surface. This large scale process requires an easy aqueous sol-gel procedure for the synthesis of the TiO2 sol. This synthesis has been simplified to facilitate the extrapolation towards an industrial scale. Results of TEM, photocatalytic properties, film hydrophilicity, and texture obtained with the simplified aqueous sol-gel synthesis (IsoP-TiO2 synthesis) show similar properties to those obtained with the standard aqueous sol-gel synthesis of TiO2 (HAc-TiO2 synthesis) developed previously. Only X-Ray Diffraction patterns showed differences, with the presence of anatase-brookite phases in IsoP-TiO2 synthesis while anatase phase only was observed in HAc-TiO2 synthesis. Both the aqueous sol-gel synthesis of pure TiO2 and the film deposition on steel by roll-coating have been successfully extrapolated to a larger scale. The photocatalytic activity and the hydrophilicity of the film were found to be unchanged when compared to films produced at a laboratory scale, thus validating the production of an efficient easy-to-clean material. Although some problems are still to be solved, this study is a hopeful first step in the development of a large scale process for self-cleaning steel production. [less ▲]

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See detailMemory consolidation in children with Specific Language Impairment: Delayed gains and susceptibility to interference in implicit sequence learning
Desmottes, Lise ULg; Maillart, Christelle ULg; Meulemans, Thierry ULg

in Journal of Clinical and Experimental Neuropsychology (2017)

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language ... [more ▼]

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language impairment (SLI). Two aspects of memory consolidation in implicit sequence learning were examined: the evolution of post-training gains in sequence knowledge (Experiment 1) and the susceptibility to interference (Experiment 2). Method and Results: In the first experiment, 18 children with SLI and 17 control children matched for sex, age, and nonverbal intelligence completed a serial reaction-time (SRT) task and were tested 24 hours and 1 week after practicing. The two groups of children attained an equal level of sequence knowledge in the training session, but the children with SLI lacked the consolidation gains displayed by the control children in the two post-training sessions. Working with a new group of children, 17 with SLI and 17 control peers, Experiment 2 examined resistance to interference by introducing a second sequence 15 minutes after the first training session. Similar results were obtained for the performance of both groups in the training session. However, although the performance of the control group improved in the post-training sessions, the performance of the SLI group deteriorated significantly during the consolidation phase due to the interfering sequence. Conclusion: These findings suggest that the consolidation phase of sequence learning is impaired in children with SLI. [less ▲]

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See detailEthylene polymerization and hydrodechlorination of 1,2-dichloroethane mediated by nickel(II) covalently anchored to silica xerogels
Mahy, Julien ULg; Claude, Vincent ULg; Sacco, Luigi et al

in Journal of Sol-Gel Science and Technology (2017), 81(1), 59-68

Ni/SiO2 cogelled xerogel catalysts have been prepared in ethanol containing nickel acetylacetonate, tetraethoxysilane (TEOS), an aqueous ammonia solution of 0.54 mol L-1 and either a commercial sylilated ... [more ▼]

Ni/SiO2 cogelled xerogel catalysts have been prepared in ethanol containing nickel acetylacetonate, tetraethoxysilane (TEOS), an aqueous ammonia solution of 0.54 mol L-1 and either a commercial sylilated ligand, 3-(2-aminoethyl)aminopropyltrimethoxysilane (EDAPMS), or a home-made new silylated pyrazolypyridine ligands, respectively 2-[4-[3-(trimethoxysilyl)propyl]-3,5-dimethyl-1H-pyrazol-1-yl]pyridine (MS-PzPy) and 2-[4-[3-(trimethoxysilyl)propyl]-3,5-dimethyl-1H-pyrazol-1-yl]-6-methylpyridine (MS-PzPyMe), able to form a chelate with a metal ion such as Ni2+. All samples form homogeneous and very highly dispersed Ni/SiO2 cogelled xerogel catalysts. The resulting catalysts are composed of nickel nanoparticles with a diameter of about 2.8 nm, located inside primary silica particles exhibiting a monodisperse microporous distribution. The silylated organic ligand has a strong influence on the textural properties of cogelled xerogel catalysts, both before and after calcination and reduction steps. Changing the nature of the silylated ligand permits tailoring textural properties such as pore volume, pore size and surface area. Homogenous nickel complexes synthesized from pyrazolylpyridine derivatives are inactive for ethylene polymerization. In opposite, heterogenous nickel-based catalysts onto silica xerogel synthesized from pyrazolylpyridine derivatives bearing a tethered trialkoxysilyl group allow increasing ethylene polymerization activity. Although nickel nanoparticles are located inside the silica crystallites, their complete accessibility, via the micropore network, has been shown. For 1,2-dichloroethane hydrodechlorination over Ni/SiO2 catalysts, the conversion of 1,2-dichloroethane is high at the temperature of 350°C and mainly ethane is produced. [less ▲]

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See detailMetamemory Following Childhood Brain Injury: A Consequence of Executive Impairment
Geurten, Marie ULg; Chevignard, Mathilde; Kerrouche, Bernadette et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2017), 23(1), 67-82

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged ... [more ▼]

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged 7 to 14 years) who had sustained a moderate to severe TBI and 44 typically developing children were recruited. Children with TBI were divided into two groups according to the severity of their executive impairment. Injury severity was determined by the Glasgow Coma Scale (GCS) score on admission or by the duration of unconsciousness. All children were then tested on both their knowledge of general memory functioning and their level of memory self-awareness, respectively assessed using total number of correct responses on an adapted version of Kreutzer et al.’s metamemory interview and a self-other discrepancy score on a questionnaire evaluating everyday memory abilities. Data analyses revealed that participants with TBI who suffered impaired executive functions demonstrated less general metamemory knowledge, and underestimated the frequency of their memory problems, compared with children with TBI who had preserved executive functions and with control participants. Considering the well-established effect of metamemory knowledge on people’s spontaneous implementation of strategies, the interest and the importance of these findings on both theoretical and clinical grounds are discussed. [less ▲]

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See detailRe-entrant inclusions in cellular solids: From defects to reinforcements
Zorzetto, Laura ULg; Ruffoni, Davide ULg

in Composite Structures (2017), 176

Abstract A contrast in Poisson ratio is a possible strategy to enhance the stiffness of composite structures. In solid materials Poisson ratio is hardly tailorable unless cellular architectures are ... [more ▼]

Abstract A contrast in Poisson ratio is a possible strategy to enhance the stiffness of composite structures. In solid materials Poisson ratio is hardly tailorable unless cellular architectures are considered. Here, we first investigated the effect of a single re-entrant inclusion acting as a defect into a regular (non-re-entrant) honeycomb lattice. Building on this, we generated regular patterns of re-entrant inclusions into a regular hexagonal cellular matrix and we characterized the apparent stiffness and Poisson ratio of the obtained structures. We also explored the role of the intrinsic material properties of the inclusion as well as of its closest environment on the interplay between the deformations of different phases in the lattice. Our main finding is that a small fraction of re-entrant inclusions (around 12%) is sufficient to generate a substantial augmentation in stiffness (300%) at constant overall relative density and without inducing strong anisotropy. Eventually, we fabricated by 3D polyjet printing bi-material composite architectures to demonstrate the superior mechanical behavior obtained exploiting the Poisson effect. [less ▲]

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See detailRapport des prospections géophysiques ESO-ESU
Nguyen, Frédéric ULg; Hermans, Thomas ULg

Report (2017)

Detailed reference viewed: 47 (20 ULg)