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See detailD'une question patrimoniale à une réflexion sur l'Etat : de l'utilité de la théorie du droit pour comprendre une décision judiciaire
Vandenbulke, Antoine ULg

in Revue de la Faculté de Droit de l'Université de Liège (2015)

The High Court of Paris was required to rule in its judgment of November 20th 2013 on the quality of public archives of telegrams written by General de Gaulle in London between 1940 and 1942. This issue ... [more ▼]

The High Court of Paris was required to rule in its judgment of November 20th 2013 on the quality of public archives of telegrams written by General de Gaulle in London between 1940 and 1942. This issue leads to a question about the status of Free France as a State, and its coexistence with Vichy France. This paper analyzes the Court's decision through the prism of Legal Theory mobilizing Hart’s reflection in terms of internal and external points of view. [less ▲]

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See detailLes techniques de restauration des prairies tempérées fonctionnent-elles sous les tropiques ?
Le Stradic, Soizig ULg; Buisson, Elise

in Forget, Michel-Pierre; Hossaert-McKey, Martine; Poncy, Odile (Eds.) Écologie tropicale: De l'ombre à la lumière (2015)

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See detailNeuromodulation in migraine: state of the art and perspectives.
MAGIS, Delphine ULg

in Expert review of medical devices (2015)

Migraine is a highly prevalent and disabling disease. The drugs prescribed for migraine prophylaxis can have intolerable side effects or can be ineffective. Neuromodulation techniques are increasingly ... [more ▼]

Migraine is a highly prevalent and disabling disease. The drugs prescribed for migraine prophylaxis can have intolerable side effects or can be ineffective. Neuromodulation techniques are increasingly used in neurology. Transcutaneous supraorbital nerve stimulation is effective in episodic migraine prevention, whereas vagus nerve stimulation provides interesting results in acute migraine therapy. Transcranial stimulation techniques gave variable, and sometimes contradictory, results. The visual cortex is the target of choice in migraine: studies in migraine prevention and aura acute treatment are encouraging. These noninvasive therapies appear safe with a low rate of side effects. Available studies of invasive occipital nerve stimulation in chronic migraine gave modest results; but invasive occipital nerve stimulation offers a new hope to highly disabled patients who failed to respond to any other treatment. In the future, neuromodulation will probably take an increasing place in migraine treatment, as add-on therapy or alternative to medications, especially because of its attractive safety profile. [less ▲]

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See detailConstructing Quebec and Wallonia: How Political Parties Speak about their Region
Mercenier, Heidi; Perrez, Julien ULg; Reuchamps, Min

in Reuchamps, Min (Ed.) Minority Nations in Multinational Federations. A comparative study of Quebec and Wallonia (2015)

Political parties are key political actors in both Quebec and Wallonia. As their foremost ambition is to govern their region, these parties clearly contribute to shaping its identity and image. This ... [more ▼]

Political parties are key political actors in both Quebec and Wallonia. As their foremost ambition is to govern their region, these parties clearly contribute to shaping its identity and image. This chapter aims at exploring how political parties in Quebec and in Wallonia speak about their region by focusing on an analysis of their electoral manifestos for the period 1994–2014. Using a quantitative and qualitative approach combining insights from lexicometry, cognitive linguistics and political science, the aims of this contribution are (i) to unravel how the parties perceive their region and its future development, (ii) to identify relevant evolutions in their perception of their respective region, and (iii) to assess to what extent parallels can be drawn between the two regions. [less ▲]

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See detailPositive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.
Bury, Daniel; Dahmane, Ismahene ULg; Derouaux, Adeline ULg et al

in Biochemical pharmacology (2015), 93(2), 141-50

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan ... [more ▼]

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan macromolecule. The essential function of the GT makes it an attractive antimicrobial target; therefore a better understanding of its function and its mechanism of interaction with substrates could help in the design and the development of new antibiotics. In this work, we have used a surface plasmon resonance Biacore((R)) biosensor, based on an amine derivative of moenomycin A immobilized on a sensor chip surface, to investigate the mechanism of binding of substrate analogous inhibitors to the GT. Addition of increasing concentrations of moenomycin A to the Staphylococcus aureus MtgA led to reduced binding of the protein to the sensor chip as expected. Remarkably, in the presence of low concentrations of the most active disaccharide inhibitors, binding of MtgA to immobilized moenomycin A was found to increase; in contrast competition with moenomycin A occurred only at high concentrations. This finding suggests that at low concentrations, the lipid II analogs bind to the acceptor site and induce a cooperative binding of moenomycin A to the donor site. Our results constitute the first indication of the existence of a positive cooperativity between the acceptor and the donor sites of peptidoglycan GTs. In addition, our study indicates that a modification of two residues (L119N and F120S) within the hydrophobic region of MtgA can yield monodisperse forms of the protein with apparently no change in its secondary structure content, but this is at the expense of the enzyme function. [less ▲]

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See detailEffect of enzymatic treatment on rheological properties, glass temperature transition and microstructure of date syrup
Abbès, Fatma; Masmoudi, Manel; Kchaou, Wissal et al

in LWT - Food Science and Technology (2015), 60

A knowledge of rheological properties is of importance in processing, handling, process design, product development and quality control. This study investigates the effect of commercial hydrolytic enzymes ... [more ▼]

A knowledge of rheological properties is of importance in processing, handling, process design, product development and quality control. This study investigates the effect of commercial hydrolytic enzymes (pectinase and cellulase) on rheological properties and glass temperature transition of date syrup. Date syrups obtained by enzymatic extraction exhibited a quasi Newtonian behaviour. The enzyme-treated date syrups showed the highest values of activation energy (Ea). Therefore, these syrups showed the most temperature dependency. Dynamic shear results revealed viscous behaviour for date syrups indicating that both syrups displayed liquid-like behaviour. Temperature significantly affected both (G') and (G''). The glass transition temperature (Tg) of date syrups varied between -39.56 and -45.74 °C depending on their composition. Glass transition temperature of date syrups decreased linearly with an increase in water content. [less ▲]

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See detailOptimal control of a Cope rearrangement by coupling the reaction path to a dissipative bath or a second active mode
Chenel, Aurélie; Meier, Christoph; Dive, Georges et al

in The Journal of Chimical Physics (2015), 142

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See detailInvesting in the Future
Pahud de Mortanges, Charles ULg

E-print/Working paper (2015)

This paper attempts to address the challenges of how to invest in Synthetic Biology firms, most of which are relatively new start-ups and unprofitable. Valuing an early-stage firm with only a brief ... [more ▼]

This paper attempts to address the challenges of how to invest in Synthetic Biology firms, most of which are relatively new start-ups and unprofitable. Valuing an early-stage firm with only a brief operating history, little or no operating profit (or even revenue), and an immature and untested business model, could be a formidable challenge. We propose a limited number of quantitative, and a larger number of qualitative criteria. An investor may consider these when faced with analyzing a new untried business, but one he/she believes has considerable potential for success in the future. [less ▲]

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See detailElevated heart rate at 24-36h after admission and in-hospital mortality in acute in non-arrhythmic heart failure.
Lancellotti, Patrizio ULg; ANCION, Arnaud ULg; Magne, Julien et al

in International journal of cardiology (2015), 182C

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study ... [more ▼]

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36h after admission for acute non-arrhythmic HF and in-hospital mortality. METHODS AND RESULTS: We examined the association of heart rate with in-hospital mortality in a cohort of 712 patients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78+/-9 vs. 72+/-12years; p=0.0021), had higher heart rate (92+/-22 vs. 78+/-18bpm; p<0.0001), NT pro-BNP (p=0.0005), creatinine (p=0.023), were often diabetics (p=0.026) and had lower systolic and diastolic blood pressures (p<0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p<0.01). With multivariable analysis, age (p=0.037), heart rate (p<0.0001), diastolic blood pressure (p<0.001), prior ischemic heart disease (p=0.02) and creatinine (p=0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p=0.007). CONCLUSIONS: Higher heart rate 24-36h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge. [less ▲]

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See detailPulmonary Hypertension in Valvular Disease: A Comprehensive Review on Pathophysiology to Therapy From the HAVEC Group.
Magne, Julien; Pibarot, Philippe; Sengupta, Partho P. et al

in JACC. Cardiovascular imaging (2015), 8(1), 83-99

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively few published data on the ... [more ▼]

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively few published data on the prevalence, impact on outcome, and management of PH with VHD. The objective of this paper is to present a systematic review of PH in patients with VHD. PH is found in 15% to 60% of patients with VHD and is more frequent among symptomatic patients. PH is associated with higher risk of cardiac events under conservative management, during valve replacement or repair procedures, and even following successful corrective procedures. In addition to its usefulness in assessing the presence and severity of VHD, Doppler echocardiography is a key tool in diagnosis of PH and assessment of its repercussion on right ventricular function. Assessment of pulmonary arterial pressure during exercise stress echocardiography may provide additional prognostic information beyond resting evaluation. Cardiac magnetic resonance is also useful for assessing right ventricular geometry and function, which provide additional prognostic information in patients with VHD and PH. [less ▲]

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See detailThe year in cardiology 2014: valvular heart disease.
Pierard, Luc ULg; Vahanian, Alec

in European heart journal (2015)

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See detailA Low-Cost Digital Image Correlation Technique for Characterising the Shear Deformation of Fabrics for Draping Studies
Pierce, R. S.; Falzon, B. G.; Thompson, M. C. et al

in Strain (2015)

A novel digital image correlation (DIC) technique has been developed to track changes in textile yarn orientations during shear characterisation experiments, requiring only low-cost digital imaging ... [more ▼]

A novel digital image correlation (DIC) technique has been developed to track changes in textile yarn orientations during shear characterisation experiments, requiring only low-cost digital imaging equipment. Fabric shear angles and effective yarn strains are calculated and visualised using this new DIC technique for bias extension testing of an aerospace grade, carbon-fibre reinforcement material with a plain weave architecture. The DIC results are validated by direct measurement, and the use of a wide bias extension sample is evaluated against a more commonly used narrow sample. Wide samples exhibit a shear angle range 25% greater than narrow samples and peak loads which are 10 times higher. This is primarily due to excessive yarn slippage in the narrow samples; hence, the wide sample configuration is recommended for characterisation of shear properties which are required for accurate modelling of textile draping [less ▲]

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See detailEnquêter sur les non-publics de la culture: quelle posture de recherche pour quel dispositif méthodologique?
Ghebaur, Cosmina ULg

in Questions de Communication (2015)

Mes travaux portent sur les non-publics de la culture et leur fabrication institutionnelle, à savoir leur production par les institutions chargées de mettre en œuvre sur un territoire donné les politiques ... [more ▼]

Mes travaux portent sur les non-publics de la culture et leur fabrication institutionnelle, à savoir leur production par les institutions chargées de mettre en œuvre sur un territoire donné les politiques culturelles les concernant. Pour explorer cette question, je me place dans la perspective initiée en sociologie de l'art par Pascale Ancel et Alain Pessin (2004) et caractérisée par la remise en question de la frontière entre publics et non-publics. On peut, écrit Martine Azam (2004), être " à la fois " public et non-public s'agissant de deux objets culturels différents ou du même objet à des moments différents. L'objectif de cet article est d'expliciter les principaux choix méthodologiques que j'ai été amenée à faire en enquêtant, avec cette posture de recherche, sur une exposition photographique en extérieur organisée dans une ville de la banlieue parisienne. [less ▲]

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See detailMultiscale variability of amphipod assemblages in Posidonia oceanica meadows
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Vermeulen, Simon et al

in Journal of Sea Research (2015), 95

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and ... [more ▼]

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and conservation. Amphipod crustaceans are key organisms in seagrass ecosystems. However, little attention has been paid to the spatial scales at which amphipod assemblages may vary. We examined variability patterns of amphipod populations inhabiting Posidonia oceanica meadows, over spatial scales spanning four orders of magnitude (1 to 1000 metres) and for two consecutive years. This study reports the scales that contributed most to spatial variation of amphipod assemblages and explores the potential processes of the observed patterns, with particular emphasis on habitat features. The number of species, the diversity and the density of some species, exhibited high variation across years. Most species showed the highest spatial variation in density and biomass at small scales (~1 and 10 m). Based on density data, the structure of amphipod assemblages did not differ at any scales investigated. The patchiness that occurred at small scales may have been only weakly related to habitat features. Instead, we postulated that behavioural processes of amphipods were likely good explanatory factors. Although, the small scale spatial variability can be an important feature of amphipod assemblages in P. oceanica meadows, many patterns probably remained undetected as they may occur at scales smaller than those investigated. [less ▲]

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See detailElements of stochastic processes 2014--2015: course material
Arnst, Maarten ULg

Learning material (2015)

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See detailAntidiabetic agents: Potential anti-inflammatory activity beyond glucose control.
Scheen, André ULg; Esser, N.; Paquot, Nicolas ULg

in Diabetes & metabolism (2015)

A growing body of evidence is emerging to show that abdominal obesity, the metabolic syndrome, type 2 diabetes, cardiovascular disease and microvascular diabetic complications are intimately related to ... [more ▼]

A growing body of evidence is emerging to show that abdominal obesity, the metabolic syndrome, type 2 diabetes, cardiovascular disease and microvascular diabetic complications are intimately related to chronic inflammation. These observations pave the way to the development of new pharmacological strategies that aim to reduce silent inflammation. However, besides specific anti-inflammatory agents, glucose-lowering medications may also exert anti-inflammatory effects that could contribute to improved outcomes in diabetic patients. Most studies have used metformin, an AMP-activated protein kinase (AMPK) activator, and thiazolidinediones (TZDs), which act as peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists. Both pharmacological classes (considered insulin-sparing agents or insulin sensitizers) appear to have greater anti-inflammatory activity than insulin-secreting agents such as sulphonylureas or glinides. In particular, TZDs have shown the widest range of evidence of lowered tissue (visceral fat and liver) and serum inflammation. In contrast, despite reducing postprandial hyperglycaemia, the effect of alpha-glucosidase inhibitors on inflammatory markers appears rather modest, whereas dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and glucagon-like peptide-1 (GLP-1) receptor agonists appear more promising in this respect. These incretin-based therapies exert pleiotropic effects, including reports of anti-inflammatory activity. No human data are available so far regarding sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Although they may have indirect effects due to reduced glucotoxicity, their specific mode of action in the kidneys does not suggest systemic anti-inflammatory activity. Also, in spite of the complex relationship between insulin and atherosclerosis, exogenous insulin may also exert anti-inflammatory effects. Nevertheless, for all these glucose-lowering agents, it is essential to distinguish between anti-inflammatory effects resulting from better glucose control and potential anti-inflammatory effects related to intrinsic actions of the pharmacological class. Finally, it would also be of major clinical interest to define what role the anti-inflammatory effects of these glucose-lowering agents may play in the prevention of macrovascular and microvascular diabetic complications. [less ▲]

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See detailThe course of anaemia in children and adolescents with Crohn's disease included in a prospective registry.
Van Biervliet, Stephanie; Smets, Francoise; Hofmann, Ilse et al

in International journal of colorectal disease (2015), 30(1), 51-6

AIM: The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). METHODS: The BELCRO registry ... [more ▼]

AIM: The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). METHODS: The BELCRO registry (inclusion May 2008-April 2010), describing current clinical treatment practice of children diagnosed with CD, provided data on age, height, body mass index (BMI), paediatric Crohn's disease activity index (PCDAI), therapy and haemoglobin (Hb) at diagnosis 12 and 24 months follow-up. Anaemia was defined as Hb < -2 sd, while severe anaemia was defined as Hb < -4 sd. Patients were classified as child </=13 and adolescent >13 years of age. RESULT: Ninety-six were included, 13 dropped out due to insufficient Hb data (37 females/46 males; median age 13.3 years, range 2.2-17.8 years). At diagnosis, the median Hb sd was -2.66 (-8.4; 1.07) and was correlated with the PCDAI (p = 0.013). At diagnosis, 51/83 (61 %) were anaemic and all had active disease. Hb z-score significantly improved (p < 0.0001) but 26/68 (38 %) remained anaemic at 12 months and 29/76 (38 %) at 24 months of follow-up. The correlation to the PCDAI disappeared. At 24 months, children were more likely to be anaemic. There was no difference in iron dose nor duration of iron supplements between children and adolescents. Iron treatment was more readily given to patients presenting with anaemia. Hb did not differ between patients with (n = 28) or without iron supplements. Half of the patients with persisting anaemia were given iron supplements, of which, only three were given intravenously. CONCLUSION: Anaemia remains an important extra-intestinal manifestation of CD in children. Physicians, lacking optimal treatment strategies, undertreat their patients. [less ▲]

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See detailTransposability of pedotransfer functions for estimating water retention of Algerian soils
Touil, Sami; Degré, Aurore ULg; Chabaca, Mohamed Nacer

in Desalination and Water Treatment (2015)

Testing the efficiency of a pedotransfer function (PTF) outside of its development data-set is one of the best ways for assessing its robustness. An important question which remains unanswered is how ... [more ▼]

Testing the efficiency of a pedotransfer function (PTF) outside of its development data-set is one of the best ways for assessing its robustness. An important question which remains unanswered is how transposable are PTFs to other agropedoclimatic contexts? Models developed and validated in a particular pedoclimatic context have been relatively little tested in other contexts. Particularly, no studies have been conducted until now to evaluate the PTFs for Algerian soils. In this study, eight (8) PTFs most frequently cited were considered. We used them to evaluate soil water retention at field capacity (FC) and wilting point (WP) on a set of 134 samples collected in the low Cheliff. The calculated Akaike information criterion and root mean square errors values showed that the Rawls, and Ghorbani Dashtaki et Homaee type 1 models were the best in estimation of soil water retention at FC (–709.795, 0.070 cm3 cm−3) and WP (–733.480, 0.064 cm3 cm−3). The poorer performances were presented by the PTFs developed on soils from Europe or United States where the organic matter values were much higher than the Algerian soils. However, the transposability of the PTFs formed from data spread from a wider area, produce more accurate predictions than those built from local data. [less ▲]

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