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See detailKLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Ali, Amjad ULg; Zhang P; Liangfang Y et al

in cell death and disease (2015)

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important ... [more ▼]

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, underlying mechanisms leading to tumor suppressive and anti-metastatic function of KLF17 still remains unknown. Here, we show that KLF17 plays an integral role in potentiating TGF-β/Smad signaling via Smad3-dependent pathway to suppress tumor progression. Intriguingly, TGF-β/Smad3 signaling induces KLF17 expression, generating a positive feedback loop. TGF-β/Smad3-KLF17 loop is critical for anti-metastasis and tumor inhibition in cancer cells. Mechanistically, silencing KLF17 reduced Smad3-DNA complex formation on Smad binding element (SBE) and affects the expression of TGF-β/Smad target genes. Moreover, KLF17 alters Smad3 binding pattern on chromatin. KLF17 regulates TGF-β target genes that are Smad3-dependent. Smad3 and KLF17 physically interact with each other via KLF17 responsive elements/SBE region. Intriguingly, TGF-β stimulates the recruitment of KLF17 on chromatin to subsets of metastasis-associated genes. Functionally, depletion of KLF17 enhanced tumorigenic features in cancer cells. KLF17 is critical for full cytostatic function of TGF-β/Smad signaling. Clinically, KLF17 expression significantly decreases during advance HCC. KLF17 shows positive correlation with Smad3 levels in cancer samples. Our data shows that enhance KLF17 activity has important therapeutic implications for targeted-therapies aimed at TGF-β/Smad3 pathway. These findings define novel mechanism by which TGF-β/Smad-KLF17 pathway mutually affect each other during cancer metastasis, provide a new model of regulation of TGF-β/Smad signaling by KLF17 and defines new insights into anti-metastatic function of KLF17. [less ▲]

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See detailSe "faire manger" par l'Autre. Stratégies féminines de définition de soi en contexte public.
Mescoli, Elsa ULg

Conference (2015, March 12)

Cette communication vise à étudier la participation des femmes migrantes marocaines à la vie sociale du « pays d’accueil » ; participation qui se réalise grâce aux activités de la vie quotidienne. En ... [more ▼]

Cette communication vise à étudier la participation des femmes migrantes marocaines à la vie sociale du « pays d’accueil » ; participation qui se réalise grâce aux activités de la vie quotidienne. En particulier, la performance publique des pratiques culinaires, observée dans une ville de la province de Milan, permet aux femmes considérées d’exercer une agency à l’intérieur des espaces institutionnellement concédés à l’expression des migrants. D’un côté, la consommation des « recettes de l’Autre » de la part de la population majoritaire détermine une incorporation de la diversité afin de la contrôler. De l’autre côté, la préparation de ces recettes consent aux migrantes d’exprimer leur subjectivité (individuelle et collective) de façon active et en présentant des aspects qui vont au-delà de la culture alimentaire. Une participation sociale fondée sur le partage de nourriture donne la possibilité aux femmes d’assumer un rôle actif dans la communauté locale, tout en affirmant ses propres spécificités. Des sujets tels que la liberté religieuse sont abordés, et certains droits peuvent être réclamés par des individus qui ont ainsi acquis une position politiquement importante au sein de la société locale. [less ▲]

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See detailMutant p53 promotes tumor cell malignancy by both positive and negative regulation of TGF-β pathway
Lei Ji; Jinjin Xu; Jian Liu et al

in Journal of Biological Chemistry (2015)

Specific p53 mutations abrogate the tumor suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort the TGF-β signaling, which paradoxically displays ... [more ▼]

Specific p53 mutations abrogate the tumor suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort the TGF-β signaling, which paradoxically displays both tumor-suppressive and pro-oncogenic function. The molecular mechanisms how mutant p53 simultaneously antagonizes tumor-suppressive and synergizes tumor-promoting function of TGF-β pathway remain elusive. Here we demonstrate that mutant p53 differentially regulates subsets of TGF-β target genes, by an enhanced binding to the MH2 domain in Smad3 upon the integration of ERK signaling, therefore disrupting the Smad3/Smad4 complex formation. Silencing Smad2, inhibition of ERK or introducing a phosphorylation defective mutation at Ser392 in p53 abrogates the R175H mutant p53 dependent regulation of these TGF- β target genes. Our study provide a mechanism to reconcile the seemingly contradictory observations that mutant p53 can both attenuate and cooperate with the TGF-β pathway to promote cancer cell malignancy in a same cell type. [less ▲]

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See detailConcomitant nodal involvement by Langerhans Cell Histiocytosis and Hodgkin Lymphoma
Geurten, Claire ULg; THIRY, Albert ULg; Jamblin, Paul et al

Poster (2015, March 12)

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis ... [more ▼]

Introduction : Langerhans cell histiocytosis is defined as a clonal neoplastic proliferation of myeloid dendritic cells that upon activation migrate from the mucosal to lymph nodes. Definitive diagnosis is made by anatomo-pathological and immunohistochemical analysis. Langerhans cell histiocytosis is rarely, yet not exceptionally, found coexisting with other malignant neoplasms, suggesting it might arise in reaction to the cytokinic secretion of malignant cells. Case : We report the case of a 10-year-old female presenting with an isolated laterocervical lymphadenopathy and a mild general condition alteration tracing back to two months earlier. Nodal biopsy was performed and revealed concomitant involvement by Langerhans cell histiocytosis and Hodgkin lymphoma. Treatment of lymphoma led to the disappearance of the whole symptomatology. Discussion : Literature beholds reports of 30 cases of the simultaneous occurence of Hodgkin lymphoma with Langerhans cell histiocytosis, which is more than fortuitous regarding the low incidence of both diseases. A common etiology could explain such an association, but it might also be possible that background inflammatory cells of Hodgkin lymphoma stimulate the proliferation of Langerhans cells, making it a reactive process when occurring simultaneously with other neoplasms. Clinicians should thus be aware of the possibility of this association and carefully exclude any other life-threatening malignant proliferation when confronted to apparently isolated Langerhans cell histiocytosis. [less ▲]

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See detailL’intégration des Marocains en Belgique, un processus tripartite
Gsir, Sonia ULg

Conference (2015, March 12)

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See detailDe quoi je me mêle ? Mais que vient faire l’Université dans l’effort de redéploiement économique et social ?
Rentier, Bernard ULg

Conference given outside the academic context (2015)

Le débat sur l'implication de l'Université dans l'activité économique de sa région ne date pas d'hier. Cette implication a même aujourd'hui acquis droit de cité en raison de plusieurs facteurs, positifs ... [more ▼]

Le débat sur l'implication de l'Université dans l'activité économique de sa région ne date pas d'hier. Cette implication a même aujourd'hui acquis droit de cité en raison de plusieurs facteurs, positifs et négatifs. Toutefois, aujourd'hui, ce volet de l'activité universitaire a pris une telle prépondérance que d'aucuns commencent à s'interroger sur l'ampleur du phénomène et à se demander si un rééquilibrage ne s'avère pas indispensable... Par ses recherches fondamentales, l'université apporte un renouveau d'idées, de concepts et de méthodes. Pour autant qu'un mécanisme prévoie un juste retour de moyens aux concepteurs et qu'un processus de conversion des avancées fondamentales et de développement vers l'application soit mis en place, le chercheur universitaire devrait se consacrer très largement à sa recherche de base. Un financement public suffisant permettrait cette focalisation et, partant, une meilleure efficacité. A défaut, le chercheur consacre une partie croissante de son temps à des développements d'applications qui le distraient de sa mission première et celle-ci en pâtit, concourant ainsi à ralentir le processus général d'innovation. Certes, il faut sortir le chercheur fondamentaliste de sa bulle (ou "tour d'ivoire") et il importe qu'il comprenne l'ensemble des rouages auxquels conduit son travail, mais il doit se focaliser sur l'amont plus que sur l'aval, sans quoi on verra se tarir la source de l'innovation (dont chacun s'accorde à dire qu'elle est génératrice de progrès). Certains ont une vocation plus appliquée et conviennent mieux pour les processus inventifs. Il est rare qu'une réelle sélection en vue de chacun de ces rôles soit assurée. Et, en général, la pénurie de moyens entraîne une usurpation des rôles. Quelles peuvent être aujourd'hui les perspectives pour un repositionnement plus performant ? [less ▲]

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See detailPhase Transformations and Crack Initiation in a High-Chromium Cast Steel Under Hot Compression Tests
Tchuindjang, Jérôme Tchoufack ULg; Neira Torres, Ingrid; Fores, Paulo et al

in Journal of Materials Engineering and Performance (2015), 24(5), 2025-2041

The mechanical behavior of the fully austenitic matrix of high-chromium cast steel (HCCS) alloy is determined by external compression stress applied at 300 and 700 C. The microstructure is roughly ... [more ▼]

The mechanical behavior of the fully austenitic matrix of high-chromium cast steel (HCCS) alloy is determined by external compression stress applied at 300 and 700 C. The microstructure is roughly characterized toward both optical and scanning electron microscopy analyses. Dilatometry is used during heating from room temperature up to austenitization to study the solid-state phase transformations, precipitation, and dissolution reactions. Two various strengthening phenomena (precipitation hardening and stress-induced bainite transformation) and one softening mechanism (dynamic recovery) are highlighted from compression tests. The influence of the temperature and the carbide type on the mechanical behavior of the HCCS material is also enhanced. Cracks observed on grain boundary primary carbides allow establishing a rough damage model. The crack initiation within the HCCS alloy is strongly dependent on the temperature, the externally applied stress, and the matrix strength and composition. [less ▲]

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See detailGenetic Control of Flowering Time in Arabidopsis: an Interactive Database
Bouché, Frédéric ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg et al

Poster (2015, March 12)

The transition to flowering is an essential step of the plant life cycle that is tightly controlled by both endogenous and environmental cues. Its regulation is extremely complex and involves hundreds of ... [more ▼]

The transition to flowering is an essential step of the plant life cycle that is tightly controlled by both endogenous and environmental cues. Its regulation is extremely complex and involves hundreds of genes that are part of highly interconnected pathways. Our knowledge of the molecular mechanisms governing the floral induction of Arabidopsis thaliana increases quickly and a significant number of reviews are published every year on this topic. However, most of them focus on a single pathway without highlighting the interconnections existing between them. Furthermore, those reviews become rapidly outdated, since our comprehension of the genetic control of flowering time evolves continuously. Hence, we believe that the current landscape of flowering time research in Arabidopsis misses an exhaustive repository of the genes involved in the control of flowering and their regulatory pathways. Here, we present a new interactive resource built around a curated database of the flowering time genes that brings together multiple pieces of information such as their function, the flowering time phenotype of mutants and overexpressing lines, the related key publications, etc. Our website thus gives access to a curated and exhaustive list of the genes involved in the regulation of flowering time in Arabidopsis as well as the regulatory pathways controlling their expression. Because of its flexibility, the database is highly dynamic and will be periodically updated with the future breakthroughs in this domain. [less ▲]

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See detailLara Croft. Avatar, femme et icône du jeu vidéo
Barnabé, Fanny ULg

Conference given outside the academic context (2015)

La séduisante archéologue Lara Croft, protagoniste de la série de jeux Tomb Raider, est aujourd'hui l'une des icônes les plus célèbres du jeu vidéo, si bien qu'elle a même dépassé les limites de ce médium ... [more ▼]

La séduisante archéologue Lara Croft, protagoniste de la série de jeux Tomb Raider, est aujourd'hui l'une des icônes les plus célèbres du jeu vidéo, si bien qu'elle a même dépassé les limites de ce médium pour se faire connaître à un public élargi (à travers des adaptations au cinéma, en comics ou encore à travers des publicités). Toutefois, ce personnage est aussi une figure complexe qui a été reçue de manières très diverses : tantôt envisagée comme un symbole féministe (Lara Croft est une héroïne forte et indépendante, loin de la demoiselle en détresse à laquelle se cantonnaient généralement les premiers jeux vidéo), elle a aussi pu être interprétée comme une représentation caricaturale et réifiante de la femme. C'est donc d'un personnage chargé de contradictions que cette conférence propose de faire le portrait. [less ▲]

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See detailPrevención cuaternaria y Clasificación Internacional de Atención Primaria, segunda edición.
Jamoulle, Marc ULg

Conference (2015, March 12)

Présentation des concepts de prevention quatenaire et de classification en soins primaires à la demande des autorités de l'université Isalud de Buenos Aires

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See detailSNOMED GP/FP RefSet and ICPC mapping Project 2010 -2015. Codificación y clasificación de diagnósticos en atención primaria y prevención cuaternaria.
Jamoulle, Marc ULg

Conference (2015, March 11)

Présentation des travaux du groupe de travail du Comité International de Classification de la Wonca sur la constitution d'un mappage entre la terminologie SNOMED-CT et la Classification Internationale de ... [more ▼]

Présentation des travaux du groupe de travail du Comité International de Classification de la Wonca sur la constitution d'un mappage entre la terminologie SNOMED-CT et la Classification Internationale de Soins Primaire ICPC-2 [less ▲]

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See detailLe métier de chercheur : Des parcours singuliers à la carrière traditionnelle profilée
Remy, Céline ULg; Balon, Floriane

Conference (2015, March 11)

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See detailClimate change : Impacts of shoreline erosion in developing countries
Ozer, Pierre ULg; Lemena, Kidja Hermann

Conference (2015, March 11)

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See detailElastic and inelastic transmission in guided atom lasers: A truncated Wigner approach
Dujardin, Julien ULg; Argüelles, Arturo; Schlagheck, Peter ULg

in Physical Review A (2015), 91

We study the transport properties of a Bose-Einstein condensate formed by an ultracold gas of bosonic atoms that is coupled from a magnetic trap into a one-dimensional waveguide. Our theoretical approach ... [more ▼]

We study the transport properties of a Bose-Einstein condensate formed by an ultracold gas of bosonic atoms that is coupled from a magnetic trap into a one-dimensional waveguide. Our theoretical approach to tackling this problem is based on the truncated Wigner method for which we assume the system to consist of two semi-infinite noninteracting leads and a finite interacting scattering region with two constrictions modeling an atomic quantum dot. The transmission is computed in the steady-state regime and we find a good agreement between truncated Wigner and matrix-product state calculations. We also identify clear signatures of inelastic resonant scattering by analyzing the distribution of energy in the transmitted atomic-matter wave beam. [less ▲]

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See detailThe Role of Government in Path- Dependent Development of SME Sector in Ukraine
Shutyak, Yuliya; Van Caillie, Didier ULg

in Journal of East-West Business (2015), 21(1), 67-90

This article studies evolution of governmental support for SME development from the times of Perestroika until 2013. Guided by institutional theory, the article revises SME development in Ukraine and ... [more ▼]

This article studies evolution of governmental support for SME development from the times of Perestroika until 2013. Guided by institutional theory, the article revises SME development in Ukraine and explains government actions through the prism of path dependence. The analysis is conducted within a matrix logic resuming the data by several periods of time corresponding to changes in the Ukrainian government and being juxtaposed to the main stages of the path dependence analytical framework. The study reveals main trends in governmental support for small business and main challenges remaining nowadays. [less ▲]

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