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See detailSynthesis of hydrophilic CuInS2/ZnS quantum dots with different polymeric shells and study of their cytotoxicity and hemocompatibility
Speranskaya, Elena Sergeevna; Sevrin, Chantal ULg; De Saeger, Sarah et al

in ACS Applied Materials and Interfaces (2016)

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See detailPolylactide-based microspheres prepared using solid-state copolymerized chitosan and D,L-lactide
Demina, Tatiana; Akopova, T.A.; Vladimirov, L.V. et al

in Materials Science and Engineering: A (2016), C59

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See detailStudy of cell growth on/in modified polymer matrices as scaffolds for tissue engineering
Markvicheva, E.; Drozdova, M.; Demina, T. et al

Poster (2016)

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See detailNetworks of prospective thoughts: the organisational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2016), 30

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailApports de l'électrophysiologie à la médecine d'expertise
WANG, François-Charles ULg

in Consilio manuque (2016), 1

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See detailLight-sensitive brain pathways and aging
Daneault, Véronique; Dumont, Marie; Massé, Eric et al

in Journal of Physiological Anthropology (2016), 35(9),

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See detailLe corps partagé : Approche clinique de la psychose
Gauthier, Jean-Marie ULg; Weber, Yves; Vermeylen, Françoise et al

Book published by Editions EME (2016)

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See detailIdentité territoriale et schizophrénie
Englebert, Jérôme ULg

in Gauthier, Jean-Marie; Weber, Yves; Vermeylen, Françoise (Eds.) et al Le corps partagé : Approche clinique de la psychose (2016)

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See detailSimplified equivalent static approach and results for deriving structural requirements - Deliverables D.11 and D.12 - Robustimpact
Demonceau, Jean-François ULg; D'Antimo, Marina ULg; Huvelle, Clara et al

Report (2016)

Deliverable 11 and 12 have been merged in the present document which can be seen as the main outcome of the activities conducted with Work Package 9 of the Robustimpact project. Section 2 presents first ... [more ▼]

Deliverable 11 and 12 have been merged in the present document which can be seen as the main outcome of the activities conducted with Work Package 9 of the Robustimpact project. Section 2 presents first the sophisticated numerical investigations conducted on a reference structure subjected to impacts of vehicles. Then, Section 3 presents in details the simplified analytical models/tools developed within the present project to predict the response of a structure (or a part of a structure) further to the impact of a vehicle. With the presented models, it is demonstrated that an accurate prediction of the structural results may be obtained and that all the parameters influencing this response are mastered. Section 4 introduces the different parametric studies which have been conducted (partly using the models/tools presented in Section 3) on 2D and 3D steel and composite structures or on composite floors. Finally, Section 5 highlights the structural requirements which can be proposed as an outcome of the performed investigations. Through this document, it is demonstrated that the different objectives of Work Package 9 have been reached in the framework of this project. [less ▲]

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See detailĐánh giá tiềm năng sử dụng phụ phẩm ngành rượu cồn để sản xuất thức ăn chăn nuôi tại Việt Nam
Tu Viet, Phu; Pham Kim, Dang; Nguyen Cong, Oanh ULg et al

in Journal of Science and Development (2016), 14(1), 36-45

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high ... [more ▼]

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high feed price due to the dependence on imported raw materials (estimated at 65-70%). The total value of imported raw materials for animal feed production in 2013 was estimated at $ 4.1 billion. Worldwide, by-products from alcohol industry has been studied and processed into main raw materials (DDG and DDGS) for animal feed production. Meanwhile in our country, these by-products are used in its raw form in livestock feeding or used for other purposes with low economic benefit. The objective of this study was to evaluate the potential uses of the by-products from alcohol industry to produce animal feed and increase the added value for these products. The main methods used in this study were Value Chain Analysis (VCA) and SWOT analysis. Results of the study showed the different value chains of the alcohol industry as well as opportunities for the use of by-products for the production of animal feed. The results also indicate the difficulties and challenges of these application. [less ▲]

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See detailDetailed results of the experimental tests - Deliverable D.5a - Robustimpact
Hoffmann, Nadine; Kuhlmann, Ulrike; Vanvinckenroye, Hélène ULg et al

Report (2016)

At the Institute for Steel Structures crash tests on columns were carried out to investigate the dynamic response of the member during the impact as well as the dynamic interaction of the member with the ... [more ▼]

At the Institute for Steel Structures crash tests on columns were carried out to investigate the dynamic response of the member during the impact as well as the dynamic interaction of the member with the surrounding structure. The tests' campaign planned by the Università degli Studi di Trento comprises of: - two full-scale tests on 3D specimens representative of the reference buildings; From two reference structures selected as cases study two representative substructures characterised by the same overall dimensions but by a symmetric and an asymmetric configuration (i.e., column layout), respectively, have been identified. The substructures, built in laboratory, are tested reproducing the collapse of a central column. The aim of the tests is to investigate the influence of the biaxial membrane effect associated with the concrete slab in a framed structure when the collapse of a column happens. - 20 tensile tests on T-stubs related to the beam-to-column joint adopted in the reference structures and in the full-scale specimens. T-stubs associated to both the column (10 specimens) and the end-plate (10 specimens) are tested. The tests are performed at two different loading speeds aiming at investigating the influence of strain rate effects on the joint performance, with particular reference to the deformation capacity. As a reference, also quasi-static tests are planned. At the Institute of Structural Design experimental tests were carried out investigating the behaviour of 2D-frames under a column loss. In addition the behaviour of composite joints under high speed loading was examined. Within the framework of the project, two tests on composite frames were tested as well as four tests on composite joints. The 2D substructure tests planned at USTUTT have the objective to evaluate the benefit of the concrete slab compared to the behaviour of the composite frame structure concerning the development of a membrane effect. For this purpose, the results of the composite frame tests will be compared to the 3D substructure tests performed at UTRE. Therefore, the test specimens of the 2D substructure tests are adapted to the 3D substructure tests. In order to compare also the results of the composite joint tests to the behaviour of the frames and to observe the influence of the joints on each other the test specimens for the joint tests are also adapted to the frame tests. Experimental impact tests were planned at the University of Liege (ULg): 22 tests on beam-to-column joints with 5 different joint configurations and 22 tests on column base joints with 4 different joint configurations. One of the objectives of the performed study was to propose realistic joints and column bases which could fit with the laboratory facilities of ULg, what induced a downscaling of the dimension of the members in comparison to the dimension of the ones met in the reference building. With the designed specimens, it is possible to investigate the response of different joint components under impact loading, for different levels of energy (small, medium and high levels), and to compare this response to the one obtained through a static test to highlight the dynamic effects. These static tests are performed for each type of specimens and will be used to clearly determine the different level of energy to be used for the impact tests. The general test setup for all tests was derived in Work Package 3 and can be found in the deliverable D.4.1 [18] of the project. [less ▲]

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See detailImpact of feeding and housing on the development ofosteochondrosis in foals—A longitudinal study
Mendoza García, Luis ULg; Lejeune, Jean-Philippe ULg; Caudron, Isabelle ULg et al

in Preventive Veterinary Medicine (2016), 127

Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of ... [more ▼]

Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of osteochondral fragments in the articulation, fissures or subchondral bone cysts in the growth cartilage. Occurrence of osteochondrosis is influenced by a complex interaction of different factors. Among these, the effect of the housing and the feeding of the foals during their first months of life, have been described as risk factors for the development of osteochondrosis. The aim of this study was to investigate the evolution of OCD lesions with a longitudinal study in 204 young foals from 6 to 18 months in comparison to the type of feeding and the type of housing conditions. These factors and OCD status were obtained by a questionnaire and radiological examination, respectively. This allowed dividing the foals into four groups according to the initial OCD status and the evolution of the condition. As a result, we found that foals fed with concentrates show a higher probability to develop OCD lesions (p = 0.06), while foals not receiving concentrates, had a higher probability to heal from existing OCD lesions (p = 0.001). This study supports the theory that management factors such as feeding or housing may influence the evolution of the osteochondrosis disease. [less ▲]

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See detailStudy of intact virus-like particles of human papillomavirus by capillary electrophoresis
Bettonville, Virginie ULg; Nicol, Jérôme ULg; Thelen, Nicolas ULg et al

in Electrophoresis (2016), 37

Virus-like particles of human papillomavirus (HPV-VLP), resulting from the self-assembly of the capsid proteins (L1 or L1 and L2), have been widely used to study HPV as they are similar to the native ... [more ▼]

Virus-like particles of human papillomavirus (HPV-VLP), resulting from the self-assembly of the capsid proteins (L1 or L1 and L2), have been widely used to study HPV as they are similar to the native virion. Moreover, two prophylactic vaccines, Gardasil® and Cervarix®, are based on HPV-VLP L1. Analytical techniques currently used to characterize HPV-VLP, such as SDS-PAGE, Western blot, ELISA, are time-consuming and semi-quantitative. In this study, capillary electrophoresis (CE) was evaluated for the analysis of intact HPV16-VLP. The usefulness of capillary inner wall coating as well as various BGEs, pH and detergent additives were investigated. Reproducible HPV-VLP analysis in CE was achieved using poly(ethylene oxide) coated capillary and a BGE containing high salt concentration and low SDS concentration. The developed method enables HPV-VLP detection in less than 10 min (migration times RSD : 1.6 %). The identity of HPV-VLP peak was confirmed by comparison with a sample obtained from a wild-type baculovirus and with VLP-based vaccine, Gardasil®, after adjuvant dissolution. Finally, we applied the developed methodology to VLP-based vaccines, demonstrating that CE could be successfully used for vaccine quality control. [less ▲]

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See detailDesign guidlines - Deliverable D.13 - Robustimpact
Charlier, Marion; Hanus, François; Vassart, Olivier et al

Report (2016)

The present document details the design guidelines which emanates from the RobustImpact project. The reasoning used is depicted below in Figure 1-1. The first step is to define the impact scenario and its ... [more ▼]

The present document details the design guidelines which emanates from the RobustImpact project. The reasoning used is depicted below in Figure 1-1. The first step is to define the impact scenario and its key parameters. Then the impact can be characterized as a hard impact or as a soft impact. The first option assumes that the kinetic energy of the impactor is absorbed by the impactor itself while the second option assumes that the kinetic energy of the impactor is mainly absorbed by the column, thus leading to plastic deformations and the activation of geometrical non-linear effects in the column. If the soft impact is considered, the buckling resistance of the column must be examined in order to evaluate if the impacted column shows sufficient residual resistance after the impact. If this is not the case, the structure will resist if it is able to sustain the load initially carried by the impacted column by redistributing it in the damaged structure, i.e. if it is able to activate alternative load path. The resistance brought by other structural elements will then be evaluated. If the impacted column is a peripheral column, the yield line theory is used to evaluate the resistance of both slab and beams. In case of a central column, Bailey’s method evaluating the slab resistance taking into account the membrane effect is used to determine the contribution of the slab. The contribution of the beams is then quantified by evaluating the corresponding P-u curve. All the methods have been validated using FEM softwares. Since the project concerns structures whose columns are impacted by vehicles, the accidental load combination must be considered. In addition, the yield strength of the steel should be considered as 𝑓𝑦,𝑑𝑦𝑛= 𝜇.𝑓𝑦> 𝑓𝑦 . Indeed was proved than the steel mechanical properties are better under dynamic loading. Nevertheless, there is for the moment no available quantification for the majoring coefficient that should apply to 𝑓𝑦 : this could be done realizing tests. [less ▲]

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See detailLongitudinal Study of Growth and Osteoarticular Status in Foals Born to Between-Breed Embryo Transfers
Peugnet, Pauline; Mendoza García, Luis ULg; Wimel, Laurence et al

in Journal of Equine Veterinary Science (2016), 37

The role of antenatal events on growth and predisposition to osteochondrosis (OC) was investigated in foals born to between-breed embryo transfers. Pony (P), saddlebred (S), and draft (D) horses were used ... [more ▼]

The role of antenatal events on growth and predisposition to osteochondrosis (OC) was investigated in foals born to between-breed embryo transfers. Pony (P), saddlebred (S), and draft (D) horses were used. Control P-P (n ¼ 21) and S-S (n ¼ 28) pregnancies were obtained by artificial insemination. Enhanced and restricted pregnancies were obtained by transferring P or S embryos into D mares (P-D, n ¼ 6 and S-D, n ¼ 8) and S embryos into P mares (S-P, n ¼ 6), respectively. Control and experimental foals were raised by their dams and recipient mothers, respectively, and weaned at age 6 months. Body measurements were recorded from birth to age 18 months. Osteochondrosis status was evaluated shortly after weaning and at age 18 months. Fetal growth was enhanced in P-D foals with overgrowth of most body segments until age 18 months. Fetal growth was restricted in S-P foals compared with S-D foals. Body weight, shoulder, and hip width of S-P foals grew slower before weaning but subsequently caught up after weaning. Other segments did not catch up, resulting in reduced body weight and withers’ height in S-P compared with S-D foals at age 18 months. The relative risk of developing OC was increased in restricted S-P foals compared with S-S and S-D foals shortly after weaning where all S-P foals were OC positive. Only two S-P foals were still OC positive at age 18 months. These data confirm the impact of the intrauterine environment on growth, skeletal health, and possibly athletic capacities of horses. [less ▲]

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See detailVerification of analytical and numerical tools - Deliverable D.5b - Robustimpact
Hoffmann, Nadine; Kuhlmann, Ulrike; Vanvinckenroye, Hélène ULg et al

Report (2016)

The numerical recalculation performed on the slab, beam and joint tests as well as the analytical recalculation of these tests have been employed as support for the experimental investigations represented ... [more ▼]

The numerical recalculation performed on the slab, beam and joint tests as well as the analytical recalculation of these tests have been employed as support for the experimental investigations represented within the previous chapter. In particular, numerical and analytical analysis have been performed to design the experimental test and the test setup for the symmetric and the asymmetric 3D test performed by UTRE. For the 2D-frame tests a numerical simulation was performed and the analytical model was validated. In addition to the recalculation of the experimental investigations on composite joints some parameters were varied in order to evaluate the influence on the behavior of the composite joints. Furthermore an analytical approach to predict the response of joints subjected to M-N-loading was investigated. In addition, analytical calculations have been performed in order to predict the results of the static and dynamic experimental tests. [less ▲]

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See detailA consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis - From evidence-based medicine to the real-life setting.
Bruyère, Olivier ULg; Cooper, C.; Pelletier, J.P. et al

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 3-11

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides practical guidance for the prioritization of interventions. Further analysis of real-world data for OA provides additional evidence in support of pharmacological interventions,in terms of management of OA pain and function, avoidance of adverse events, disease-modifying effects and long-term outcomes, e.g., delay of total joint replacement surgery, and pharmacoeconomic factors such as reduction in healthcare resource utilization. This article provides an updated assessment of the literature for selected interventions in OA, focusing on real-life data, with the aim of providing easy-to-follow advice on how to establish a treatment flow in patients with knee OA in primary care clinical practice, in support of the clinicians’ individualized assessment of the patient. In step 1, background maintenance therapy with symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) is recommended, for which high-quality evidence is provided only for the prescription formulations of patented crystalline glucosamine sulfate and chondroitin sulfate. Paracetamol may be added for rescue analgesia only,due to limited efficacy and increasing safety signals. Topical non-steroidal anti-inflammatory drugs (NSAIDs) may provide additional symptomatic treatment with the same degree of efficacy as oral NSAIDs without the systemic safety concerns. Oral NSAIDs maintain a central role in step2 Advanced management of persistent symptoms. However, oral NSAIDs are highly heterogeneous in terms of gastrointestinal and cardiovascular safety profile, and patient stratification with careful treatment selection is advocated to maximize the risk: benefit ratio. Intra-articular hyaluronic acid as a next step provides sustained clinical benefit with effects lasting up to 6 months after a short-course of weekly injections. As a last step before surgery, thes low titration of sustained-release tramadol, aweak opioid, affords sustained analgesia with improved tolerability. [less ▲]

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See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Bruyère, Olivier ULg; Altman, R.D.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 12-17

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) including glucosamine sulfate (GS) and chondroitin sulfate (CS) as first-line therapy for knee osteoarthritis (OA). Numerous studies are published on the use of SYSADOAs in OA; however, the efficacy of this class is still called into question largely due to the regulatory status, labeling and availability of these medications which differ substantially across the world. Examination of the evidence for the prescription patented crystalline GS (pCGS) formulation at a dose of 1500 mg once-daily demonstrates superiority overother GS and glucosamine hydrochloride (GH) formulations and dosage regimens. Thus, the ESCEO task force advocates differentiation of prescription pCGS over other glucosamine preparations. Long-term clinical trials andreal-life studies show that pCGS may delay joint structural changes, suggesting potential benefit beyond symptom control when used early in the management of knee OA. Real-life pharmacoeconomic studies demonstrate a long-term reduction in the need for additional pain analgesia and non-steroidal anti-inflammatory drugs (NSAIDs) with pCGS, with a significant reduction of over 50% in costs associated with medications, healthcare consultations and examinations over 12 months. Furthermore, treatment with pCGS for at least 12 months leads to a reduction in the need for total joint replacement for at least 5 years following treatment cessation. Thus, pCGS(1500 mg od) is a logical choice to maximize clinical benefit in OA patients, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

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