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Peer Reviewed
See detailMechanochemical Unfolding of Artificial Helical Foldamers by Single-Molecule Force Spectroscopy
Devaux, Floriane ULiege; Li, Xuesong; Huc, Ivan et al

Poster (2017, June 11)

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See detailImpact of formulation and process parameters on near-infrared spectra: Application for water determination in biopharmaceuticals
Clavaud, Matthieu ULiege; Roggo, Yves; Allmendinger, Andrea et al

Poster (2017, June 11)

Traditionally, the water content of freeze-dried biopharmaceuticals is determined by time-consuming methods such as Karl Fischer titration. As a fast and non-destructive method, many studies demonstrated ... [more ▼]

Traditionally, the water content of freeze-dried biopharmaceuticals is determined by time-consuming methods such as Karl Fischer titration. As a fast and non-destructive method, many studies demonstrated the efficiency of Near-Infrared (NIR) spectroscopy for that purpose [1]. In this study, NIR was applied to different freeze-dried monoclonal antibody. The aim was to evaluate the robustness of a NIR model depending on formulation composition and process parameters of the lyophilization parameters, and the benefits of NIR when developing a freeze-drying cycle for a new pharmaceutical product. A full Design of experiments (DoE) was established in order to produce materials with various formulations and various process parameters. As a first step, a calibration model was created and validated. The model creation was based on 4 target lyophilized cycles which were manufactured to obtain samples with different water content concentration. Then, 20 lyophilized cycles were produced according to the DoE. Two levels of protein and sucrose concentration, and two levels of pressure / primary drying temperature and process time were investigated. Furthermore, several samples of each experiment stored at different temperature and relative humidity conditions were evaluated. Chemometrics using Principal Component Analysis (PCA) and Partial Least Squares (PLS) were used to evaluate the process variations and to determine the water content, respectively. NIR is capable to differentiate between different lyophilization process conditions, based on chemometrics. Robust calibration NIR model for water determination was generated against KF independent on lyophilization process parameters and formulation composition. NIR is suitable and robust method for drug product development of freeze-dried formulation. [less ▲]

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See detailDe Rome à la Grèce et retour : langue, pouvoir et identité sous l'Empire romain
Rochette, Bruno ULiege

Conference (2017, June 10)

Une des conséquences majeures de la conquête romaine fut la diffusion du latin et de la culture romaine dans les pays soumis. Plusieurs textes de l’époque impériale pourraient faire croire que le latin ... [more ▼]

Une des conséquences majeures de la conquête romaine fut la diffusion du latin et de la culture romaine dans les pays soumis. Plusieurs textes de l’époque impériale pourraient faire croire que le latin est devenu une langue universelle utilisée à travers tout l’Empire romain : Pline l’Ancien, Plutarque, Pline le Jeune, Martial, saint Augustin. Qu’en est-il en réalité ? Rome n’a pas développé de politique linguistique. Son attitude à l’égard des problèmes sociolinguistiques fut souple et adaptée aux exigences réelles de chaque situation. Sous la République, on constate en effet une grande souplesse dans l’utilisation des langues par les magistrats romains lorsqu’ils sont en contact avec la Grèce. Même si le bilinguisme est fréquent chez les Romains de la République, dans la sphère publique, le latin conserve un rôle de langue de prestige, langue de la domination de Rome. Malgré cette souplesse, une concurrence naturelle s’est instaurée entre la langue des dominants et celle des dominés. En Occident, le latin devint l’unique langue de communication, orale comme écrite, tandis qu’en Orient, on assiste à une situation paradoxale : l’hellénisation des Romains, due au statut culturellement élevé du grec. Cette situation dichotomique n’implique toutefois pas un fractionnement en deux camps imperméables aux influences linguistiques et culturelles réciproques : ni l’Orient ni l’Occident ne sont deux domaines complètement fermés. [less ▲]

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See detailBone Markers and Vascular Calcification in CKD-MBD
DELANAYE, Pierre ULiege

Conference (2017, June 10)

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See detailEvaluation of dopaminergic terminal loss in a Parkinson's disease rat model, [18F]FDOPA versus [18F]FMT microPET.
Becker, Guillaume ULiege; Bahri, Mohamed Ali ULiege; Michel, A et al

Conference (2017, June 10)

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical ... [more ▼]

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [18F]fluoro-3,4-dihydroxyphenyl-L-alanine ([18F]FDOPA) and 6-[18F]fluoro-L-m-tyrosine ([18F]FMT). Because the imaging signal is theoretically less contaminated by metabolites, [18F]FMT should be more sensitive to moderate fluctuations of DA activity, and closely related to post-mortem measures of striatal dopaminergic deficiency. We used a within-subject design to measure striatal [18F]FMT and [18F]FDOPA uptake in eight partially lesioned, eight fully lesioned and ten sham-treated rats. Animals were pretreated with an L-aromatic amino acid decarboxylase (AADC) inhibitor. A catechol-O-methyl transferase inhibitor was also given before [18F]FDOPA PET. Quantitative estimates of striatal uptake were computed using conventional graphical Patlak method (with the tissue-derived uptake rate constant Kc as outcome). Striatal dopaminergic deficiencies were measured with apomorphine-induced rotations and post-mortem striatal DA content. We observed a strong relationship between [18F]FMT and [18F]FDOPA estimates of decreased uptake in the denervated striatum. However, only [18F]FMT Kc succeeded to discriminate between the partial and the full 6-OHDA lesion and correlated well with the post-mortem striatal DA content. This study demonstrated the higher sensitivity of [18F]FMT, with respect of [18F]FDOPA, to investigate DA terminals loss in 6-OHDA rats, and open the way to in vivo AADC activity targeting in future investigations on progressive PD models. [less ▲]

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See detailLa place de l’éthique dans la clinique du lien social
Englebert, Jérôme ULiege; Gesché, Michèle; Kalonji, Johan

Conference (2017, June 09)

Detailed reference viewed: 26 (1 ULiège)
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See detailHeavy or not ? Analysing drum placements in hard rock music
Pirenne, Christophe ULiege

Conference (2017, June 09)

The aim of this study is to verify—thanks to computer musical analysis—if downbeats and backbeats placements are different when a drummer plays in a hard rock or in a funk style. In other words, does beat ... [more ▼]

The aim of this study is to verify—thanks to computer musical analysis—if downbeats and backbeats placements are different when a drummer plays in a hard rock or in a funk style. In other words, does beat placements contribute to the heaviness of hard rock? In the field of popular music, many authors admit that there are three ways of placing the bass drum and snare drum beats with respect to metronomic time: either an anticipation, a perfect coincidence, or a slight delay. While the repertoires where the notes coincide with the metronomic time are often described as mechanical and a little cold, the anticipated notes would have a more propitious character to the dance and the delayed notes, would produce a music with a heavy character. These impressions were very often mentioned by those working on heavy metal (Waltzer, Brennan), but they have not been scientifically proven to the extent that these variations are counted in milliseconds. Two new IRCAM software, Audiosculpt and OpenMusic, now make it possible to measure very precisely these smallest variations. Thanks to this software, I will analyze the snare and bass drum hits in a few funk and hard rock songs released in 1970: James Brown's Get Up (I Feel Like Being A) Sex Machine and Super Bad (with "Jabo" Starks on drums) (which were already analyzed in Danielsen’s Presence and Pleasure, 2006). These songs will be compared with Black Night by Deep Purple (Ian Paice on drums), Uriah Heep's Gypsy (Alex Napier on drums) and Led Zepplin's Immigrant Song (John Bonham on drums). With this small sample, I will of course not be able to draw conclusions for hard rock as a whole, but if differences appear, it will be necessary to work on metadata to know if delaying the beats is a representative practice or simply a clean playing style for some drummers. [less ▲]

Detailed reference viewed: 38 (1 ULiège)
See detailBio- and CO2-sourced polyhydroxyurethanes for hydrogels coatings, foams and high performance adhesives
Gennen, Sandro ULiege; Panchireddy, Satyannarayana ULiege; Grignard, Bruno ULiege et al

Poster (2017, June 09)

Due to concerns about global warming combined with the decrease of fossil resources, the chemical transformation of carbon dioxide (CO2) into added-value products has gained interest in both academic and ... [more ▼]

Due to concerns about global warming combined with the decrease of fossil resources, the chemical transformation of carbon dioxide (CO2) into added-value products has gained interest in both academic and industrial fields. Indeed, CO2 can be viewed as a cheap, non-toxic and renewable C1 building block precursor of sophisticated organic molecules and polymers. One representative example of CO2 transformation includes the synthesis of various (bis)cyclic carbonates via CO2/epoxide coupling.1-3 Bis-cyclic carbonates were then valorized as monomers for the synthesis of series of novel low carbon footprint poly(hydroxyurethane)s (PHUs). These polymers are now exploited to produce sustainable materials including foams for thermal insulation,4 hydrogels (for potential biomedical use)5 and high performance adhesives and glues (for metal, glass and wood). [less ▲]

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See detailDevelopment of an HPTLC method for determination of hypoglycin A in aqueous extracts of seedlings and samaras of Acer species.
Habyarimana, Jean Belt Adélite ULiege; Baise, Etienne; Douny, Caroline ULiege et al

E-print/Working paper (2017)

Hypoglycin A (HGA) is a toxin contained in seeds of the sycamore maple tree (Acer pseudoplatanus). Ingestion of this amino acid causes equine atypical myopathy (AM) in Europe. Another variety, A. negundo ... [more ▼]

Hypoglycin A (HGA) is a toxin contained in seeds of the sycamore maple tree (Acer pseudoplatanus). Ingestion of this amino acid causes equine atypical myopathy (AM) in Europe. Another variety, A. negundo, is claimed to be present where AM cases were reported in the US. For unknown reasons, occurrence of this disease has increased. It is important to define environmental key factors that may influence toxicity of samaras from Acer species. In addition, the content of HGA in seedlings needs to be determined since AM outbreaks, during autumn period when the seeds fall but also during spring when seeds are germinating. The present study aims to validate a reliable method using high performance thin layer chromatography for determination and comparison of HGA in samaras and seedlings. The working range of the method was between 20 μg HGA to 408 μg HGA per ml water, corresponding to 12 - 244 mg/kg fresh weight or 40 - 816 mg/kg dry weight, taking into account of an arbitrary average dry matter content of 30%. Instrumental limit of detection and limit of quantification were of 10 µg HGA/ml and 20 µg HGA/ml water, respectively. Instrumental precision was 4% (RSD on 20 repeated measurements) while instrumental accuracy ranged between 86% and 121% of expected value. The HGA recovery of the analytical method estimated from spiked samaras and seedlings samples ranged between 63 and 103%. The method was applied to 9 samples of samaras from Acer pseudoplatanus, A. platanoides and A. campestre and 5 seedlings samples from A. pseudoplatanus. The results confirm detection of HGA in samaras from A. pseudoplatanus and the absence of detection in samaras of other tested species. They also suggest that detected levels of HGA are highly variable. This confirmed the suitability of the method for HGA detection in samaras or seedling. [less ▲]

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See detailMethodological approach for the implementation of a simulator in augmented reality in a radiation therapy department
Servotte, Jean-Christophe ULiege; Guillaume, Michèle ULiege; BOGA, Deniz ULiege et al

in International Journal of Healthcare Management (2017), 10(3), 154-159

Radiation therapy (RT) is one of the cornerstones for the treatment of cancer. In most countries RT machines are handled by professionals benefitting from an ad hoc training in theoretical knowledge as ... [more ▼]

Radiation therapy (RT) is one of the cornerstones for the treatment of cancer. In most countries RT machines are handled by professionals benefitting from an ad hoc training in theoretical knowledge as well as technical and non-technical skills. In Belgium, RT departments are hiring in nurses for this activity. In countries where there is a specified core curriculum for basic training of radiation technologist, this basic training falls short once in practice and there is an obvious requirement for a continuous updating of skills in order to keep up with the accelerating evolution of technology. Therefore, the decision has been taken to implement a simulator in augmented reality in the RT department in Liège, to face the double challenge i.e. basic professional training as well as continuous education in technical and nontechnical skills and Crew Resource Management. We describe a methodological approach to implement this simulator in augmented reality. [less ▲]

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See detailLe principe non bis in idem et les procédures mixtes : un camouflet infligé à la jurisprudence Zalotoukhine ?
Michiels, Olivier ULiege; Falque, Géraldine ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (2017/23), 1069-1078

Pour lutter contre certains comportements socialement inacceptables, les États peuvent concevoir des réponses juridiques complémentaires au moyen de procédures mixtes pour autant que celles-ci forment un ... [more ▼]

Pour lutter contre certains comportements socialement inacceptables, les États peuvent concevoir des réponses juridiques complémentaires au moyen de procédures mixtes pour autant que celles-ci forment un tout cohérent, c’est-à-dire qu’elles soient liées par un lien matériel et temporel suffisamment étroit. Le cumul des sanctions pénales et administratives est autorisé dès lors que les deux procédures poursuivent des buts complémentaires et traitent d’aspects différents de l’acte préjudiciable, que le cumul des sanctions soit prévisible, qu’il n’y ait pas de répétition dans la collecte et dans l’appréciation des preuves et qu’un mécanisme de compensation entre les sanctions soit prévu. [less ▲]

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See detailCoherent backscattering of bosonic matter-wave in the presence of disorder and interaction
Chrétien, Renaud ULiege; Dujardin, Julien; Petitjean, Cyril ULiege et al

Poster (2017, June 09)

Coherent backscattering, which is an enhancement of the backscattered intensity of a light going through a medium made of point-like scatterers, is known as one of the most robust interference effects. It ... [more ▼]

Coherent backscattering, which is an enhancement of the backscattered intensity of a light going through a medium made of point-like scatterers, is known as one of the most robust interference effects. It has been shown, although it is nowadays not fully understood yet, that in the presence of non-linearities, this enhancement turns to an inhibition. We propose to study that effect by means of a system in which we study the transport of a Bose-Einstein condensate through Aharonov-Bohm rings in the presence of interaction and disorder. We find that our system is indeed a good candidate to observe the coherent peak’s inversion and is also suitable for more feasible theoretical calculations than in the original case. [less ▲]

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See detailVandalization of A.Kapoor's "Dirty corner"
Verbeeck, Muriel ULiege

Scientific conference (2017, June 09)

Detailed reference viewed: 18 (0 ULiège)
See detailAccompagner et prendre soin des personnes âgées : sensibilisation à l’âgisme et à son impact en psychopathologie
Missotten, Pierre ULiege

Conference given outside the academic context (2017)

Detailed reference viewed: 21 (3 ULiège)
See detailLa caricature par la manière : la technique des images selon les Goncourt
Stienon, Valérie ULiege

Conference (2017, June 09)

Retraçant le parcours de Gavarni, évoquant leur amitié avec Rops, commentant les gravures destinées à illustrer leurs propres ouvrages, les Goncourt ne tiennent pas seulement un discours sur l’esthétique ... [more ▼]

Retraçant le parcours de Gavarni, évoquant leur amitié avec Rops, commentant les gravures destinées à illustrer leurs propres ouvrages, les Goncourt ne tiennent pas seulement un discours sur l’esthétique de l’image, ils disent aussi la médiation technique qui est à son origine. Gravure, lithographie, eau-forte ont leur place dans ce discours certes discret, mais précis et récurrent, qui conduit à s’interroger sur un savoir technique de la caricature propre aux Goncourt. La communication vise d’abord à mettre en évidence la nature et la portée de leurs propos sur les étapes matérielles intervenant dans la fabrique des images caricaturales, que ce savoir émane des sociabilités artistiques et culturelles (société des aquafortistes à laquelle est lié Rops, notamment) ou d’une expérience de participation à la presse. Il s’agit ensuite de déceler, dans l’essai, la fiction romanesque et le journal, les prises de positions manifestées à travers les valeurs, les avantages et les critiques que les Goncourt attribuent à ces techniques, à une époque où la caricature oscille entre les possibles de la gravure sur bois et les visées industrielles de la lithographie. [less ▲]

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See detailX-LAG ou comment ils sont devenus si grands ?
BECKERS, Albert ULiege

Scientific conference (2017, June 09)

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See detailEMT and inflammation: inseparable actors of cancer progression.
Suarez-Carmona, Meggy; Lesage, Julien; Cataldo, Didier ULiege et al

in Molecular Oncology (2017)

Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters ... [more ▼]

Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters progression to a metastatic stage, as has been extensively reviewed lately. Indeed, inflammatory cells persisting in the tumor establish a cross-talk with tumor cells that may result in a phenotype switch into tumor-supporting cells. This has been particularly well described for macrophages and is referred to as tumor-associated "M2" polarization. Epithelial-to-mesenchymal transition (EMT), the embryonic program that loosens cell-cell adherence complexes and endows cells with enhanced migratory and invasive properties, can be co-opted by cancer cells during metastatic progression. Cancer cells that have undergone EMT are more aggressive, displaying increased invasiveness, stem-like features and resistance to apoptosis. EMT programs can also stimulate the production of pro-inflammatory factors by cancer cells. Conversely, inflammation is a potent inducer of EMT in tumors. Therefore, the two phenomena may sustain each other, in an alliance for metastasis. This is the focus of this review, where the interconnections between EMT programs and cellular and molecular actors of inflammation are described. We also recapitulate data linking the EMT/inflammation axis to metastasis. [less ▲]

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See detailLe portrait-robot de l'élu(e) de demain
Geelkens, Mélanie; Grandjean, Geoffrey ULiege

Article for general public (2017)

Detailed reference viewed: 26 (3 ULiège)
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See detailSeparable states with infinitely many separable decompositions
Neven, Antoine ULiege; Bastin, Thierry ULiege

Poster (2017, June 09)

Despite intense effort in the past decades, developing a general criterion for identifying separable mixed states is still an open problem. In this context, the Positive Partial Transpose (PPT) criterion ... [more ▼]

Despite intense effort in the past decades, developing a general criterion for identifying separable mixed states is still an open problem. In this context, the Positive Partial Transpose (PPT) criterion constituted an important first step towards practical entanglement detection techniques and was later used to investigate the auxiliary problem of finding separable decompositions for separable states. In this poster, we use the rank diminishing method proposed by B. Kraus et al. [PRA 61, 062302 (2000)], that exploits the PPT property to reconstruct separable decompositions, to study the separable decompositions of symmetric PPT states of 3 qubits. We show that any 3-qubit symmetric product states always belong to an optimal separable decomposition of a PPT symmetric 3-qubit state with maximal birank. [less ▲]

Detailed reference viewed: 21 (3 ULiège)