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See detailConférence-débat avec le Raoul Collectif
Cormann, Grégory ULg; Hamers, Jérémy ULg

Conference given outside the academic context (2017)

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See detailMultidisciplinary rehabilitation program after breast cancer: benefits on physical function, anthropometry and quality of life.
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; Tomasella, Marco ULg et al

in European Journal of Physical and Rehabilitation Medicine (2017)

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered ... [more ▼]

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program has been little studied so far. AIM: To determine the benefits of a three-month multidisciplinary rehabilitation program among women after breast cancer treatment. DESIGN: Controlled no-randomized trial. SETTING: University for outcomes, University Hospital Center for interventions. POPULATION: Two hundred and nine outpatients who have been treated for a primary breast carcinoma. METHODS: Patients were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a rehabilitation program of three months including physical training and psycho-educational sessions. The assessments, performed before and after the program, included functional assessments ("Sit and Reach Test", maximal incremental exercise test and "Six-Minute Walk Test"), body composition measurements (body mass index (BMI) and body fat percentage) and a questionnaire (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30). RESULTS: After three months, flexibility, walking distance and all parameters measured during the maximal incremental exercise, except maximal heart rate, were significantly improved in the experimental group. The body fat percentage was significantly decreased and a significant improvement was observed for perceived health status (quality of life), functional role, emotional state, physical, cognitive and social functions and for most symptoms. In the control group, most of these improvements didn't appear and a significant increase in BMI and body fat percentage was observed. CONCLUSIONS: This trial identifies the benefits of a well detailed multidisciplinary rehabilitation program, including physical re-conditioning and psycho-educational sessions, with important improvements in functional capacity, body composition and the majority of functions and symptoms among women after breast cancer treatment. CLINICAL REHABILITATION IMPACT: Through its results, this study could contribute to the development of hospital quality standards for oncologic rehabilitation. Physiotherapists can efficiently propose this kind of multidisciplinary rehabilitation program. [less ▲]

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See detailNew PVT Metrics with an Improved Sensitivity to Sleep Deprivation: Analysis from Short to Long Time Intervals
Latour, Philippe ULg; Van Droogenbroeck, Marc ULg

in Managing Fatigue 2017 - Online Proceedings - http://fatigueconference2017.com/presentations.html (2017, March 20)

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See detailSynergistic observations of the giant planets with HST and JWST: Jupiter's auroral emissions
Grodent, Denis ULg

Conference (2017, March 20)

The James Webb Space Telescope is perfectly suited to observe most Solar System objects, including the extended giant planets. Its high sensitivity, high spatial resolution, field of view, very high ... [more ▼]

The James Webb Space Telescope is perfectly suited to observe most Solar System objects, including the extended giant planets. Its high sensitivity, high spatial resolution, field of view, very high spectral resolution and wide spectral coverage all combine to make JWST a fantastic instrument that will result in significant advances and progress in most fields of Solar System exploration. Here, we focus on the case of Jupiter’s aurora for several reasons. 1) The auroral emissions on Jupiter are very intense, both in ultraviolet and in infrared. Each of these bandpasses is bringing complementary information on how Jupiter is interacting with its near and distant environment. 2) Even though Jupiter’s aurora appears to be responding to the conditions prevailing in the solar wind, contrary to the Earth it is a permanent emission that can also be observed on the sunlit side of the planet. 3) The NASA Juno mission is currently exploring the magnetosphere and the atmosphere of this planet with a suite of in situ and remote instruments, including an ultraviolet spectrograph (UVS) and an infrared imaging spectrograph (JIRAM). The Juno mission is gathering a broad scientific community that will foster the study of Jupiter’s system for several years. 4) A large HST program was allocated in support of the NASA Juno prime mission (GO-14634) and is currently providing us with regular movies of Jupiter’s ultraviolet aurora. They provide a global magnetospheric context for the different Juno instruments, as well as for the numerous ground based (infrared) and space based observatories participating to the Juno mission. 5) It is currently very difficult to plan truly simultaneous UV and IR observations, mainly because of the inherent limitations of Earth based infrared telescopes. As a result, comparisons of Jupiter’s auroral emissions rest on a very limited dataset. Nevertheless, they are suggesting similarities and discrepancies between IR and UV aurorae, the study of which would greatly benefit from synergistic observations with HST and JWST. 6) The case of Saturn’s aurora is as important, especially in view of the upcoming ‘Grand Finale’ of the Cassini mission, and all above arguments apply to Saturn as well. The case of Uranus and Neptune’s aurorae still belongs to the area of discovery and will take full advantage of JWST’s advanced capabilities. [less ▲]

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See detailCatalytic functionalisation of starch and amylose using plant oils: towards polymeric materials and composites
Scholten, Philip ULg; Söyler, Zafer; Detrembleur, Christophe ULg et al

Poster (2017, March 19)

Fossil fuels have been the main source of starting materials for the chemical industry over the last century. Especially synthetic polymers rely on this feedstock and are indispensible for mankind’s ... [more ▼]

Fossil fuels have been the main source of starting materials for the chemical industry over the last century. Especially synthetic polymers rely on this feedstock and are indispensible for mankind’s technological advances and status quo. However, a shift to renewable and sustainable resources is needed, as the end of the fossil fuel era is in sight. Biomass presents one possible alternative to fossil fuels, as it consists of a large pool of different chemicals and is inexhaustible. Cellulose, and the closely related starch and amylose, are available cheaply from plants and have favourable properties, such as high strength, thermal stability and biodegradability. However, such poly(saccharides) have been difficult to use directly as materials because of the lack of thermoplasticity, low solubility and high hydrophilicity. Modifications are thus necessary to be able to exploit their advantageous properties. Recently, our group published the catalytic transesterification of maize starch with different plant oils to obtain fully renewable fatty acid starch esters in a sustainable fashion. Polymeric materials with glass transition temperatures (Tgs), soluble in common organic solvents and an increased hydrophobicity were obtained. Compatibilisation tests of the modified starch and amylose with low-density poly(ethylene) (LDPE) and cellulose are being investigated to obtain composites of commodity plastics with improved mechanical properties. [less ▲]

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See detailLichtenstein procedure under local anaesthesia
DETRY, Olivier ULg

Conference (2017, March 18)

LICHTENSTEIN REPAIR UNDER LOCAL ANAESTHESIA Pr Olivier Detry, Dpt of Abdominal Surgery and Transplantation, CHU Liège, Liège, Belgium. Email: oli.detry@chu.ulg.ac.be Despite many studies confirming the ... [more ▼]

LICHTENSTEIN REPAIR UNDER LOCAL ANAESTHESIA Pr Olivier Detry, Dpt of Abdominal Surgery and Transplantation, CHU Liège, Liège, Belgium. Email: oli.detry@chu.ulg.ac.be Despite many studies confirming the feasibility and the interest of local anaesthesia for inguinal hernia repair [1-3], its use is not generalized amongst abdominal surgeons. The advantages of local anaesthesia are indeed clear, including reduced costs, reduced hospital stay and reduced post operative pain. The success of the procedure depends on the skills and the motivation of the surgeon, of the nursing teams, and of the patient him/herself. Perfect knowledge of the surgical technique and of the regional nerve anatomy is required. The Lichtenstein repair may be easily performed under local anaesthesia, but should be proposed in the early experience to non-obese patients suffering from limited inguinal hernia. It can even be performed by surgical residents [4]. Practically, local anaesthesia requires some patience and quiet in the operative room. Operators should be aware that the action of local anaesthesia is delayed after injection. Local anaesthetics should be buffered [5] and at body temperature at time of injection. Local anaesthetics containing Adrenalin allow longer pain control, with limitation of bleeding and less toxicity. Large and brutal movements should be avoided. Transversus abdominis plane (TAP) block can also be proposed [6]. The surgical and anaesthetic techniques for inguinal hernia repair should be tailored to the specific characteristics of the hernia and of the patient. There is no method of choice that might fit for every patient. References [1] van Veen RN, Mahabier C, Dawson I, Hop WC, Kok NF, Lange JF, et al. Spinal or local anesthesia in lichtenstein hernia repair: a randomized controlled trial. Ann Surg 2008;247:428-433. [2] Verstraete L, Becaus N, Swannet H, Ceelen W, Duchateau L, Speybroeck N. Long term outcome after lichtenstein hernia repair using general, locoregional or local anaesthesia. Acta Chir Belg 2015;115:136-141. [3] Dhankhar DS, Sharma N, Mishra T, Kaur N, Singh S, Gupta S. Totally extraperitoneal repair under general anesthesia versus Lichtenstein repair under local anesthesia for unilateral inguinal hernia: a prospective randomized controlled trial. Surg Endosc 2014;28:996-1002. [4] Paajanen H, Varjo R. Ten-year audit of Lichtenstein hernioplasty under local anaesthesia performed by surgical residents. BMC Surg 2010;10:24. [5] Ball EL, Sanjay P, Woodward A. Comparison of buffered and unbuffered local anaesthesia for inguinal hernia repair: a prospective study. Hernia : the journal of hernias and abdominal wall surgery 2006;10:175-178. [6] Milone M, Di Minno MN, Musella M, Maietta P, Salvatore G, Iacovazzo C, et al. Outpatient inguinal hernia repair under local anaesthesia: feasibility and efficacy of ultrasound-guided transversus abdominis plane block. Hernia : the journal of hernias and abdominal wall surgery 2013;17:749-755. [less ▲]

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See detailRNAi inhibition of feruloyl CoA 6'-hydroxylase reduces scopoletin biosynthesis and post-harvest physiological deterioration in cassava (Manihot esculenta Crantz) storage roots.
Liu, Shi; Zainuddin, Ima M.; Vanderschuren, Hervé ULg et al

in Plant Molecular Biology (2017)

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava ... [more ▼]

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava is seriously constrained by the rapid post-harvest physiological deterioration (PPD) of its roots that occurs within 24-72 h of harvest, rendering the roots unpalatable and unmarketable. PPD limits cassava's marketing possibilities in countries that are undergoing increased development and urbanisation due to growing distances between farms and consumers. The inevitable wounding of the roots caused by harvesting triggers an oxidative burst that spreads throughout the cassava root, together with the accumulation of secondary metabolites including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one) is the most abundant. Scopoletin oxidation yields a blue-black colour, which suggests its involvement in the discoloration observed during PPD. Feruloyl CoA 6'-hydroxylase is a controlling enzyme in the biosynthesis of scopoletin. The cassava genome contains a seven membered family of feruloyl CoA 6'-hydroxylase genes, four of which are expressed in the storage root and, of these, three were capable of functionally complementing Arabidopsis T-DNA insertion mutants in this gene. A RNA interference construct, designed to a highly conserved region of these genes, was used to transform cassava, where it significantly reduced feruloyl CoA 6'-hydroxylase gene expression, scopoletin accumulation and PPD symptom development. Collectively, our results provide evidence that scopoletin plays a major functional role in the development of PPD symptoms, rather than merely paralleling symptom development in the cassava storage root. [less ▲]

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See detailPetite analyse critique des filtres à l’entrée des études de médecine
Detroz, Pascal ULg

Scientific conference (2017, March 18)

présentation de la pertinence de filtres à l'entrée de la filière médecine

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See detailL’aide docimologique dans le cadre d’un test d’orientation
Detroz, Pascal ULg

Scientific conference (2017, March 18)

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See detailApprentissage et mémoire chez l'enfant et l'adulte trisomique 21
Comblain, Annick ULg

Conference (2017, March 17)

Si le profil langagier des personnes trisomiques 21 est de mieux en mieux connu et décrit, certains aspects du développement et du fonctionnement cognitif des personnes atteintes demeurent encore peu ... [more ▼]

Si le profil langagier des personnes trisomiques 21 est de mieux en mieux connu et décrit, certains aspects du développement et du fonctionnement cognitif des personnes atteintes demeurent encore peu étudiés. Ainsi, les conséquences de la présence d’un chromosome surnuméraire dans leur patrimoine génétique, sur des domaines tels que le développement mnésique, les apprentissages académiques (lecture et arithmétique) ou la problématique du vieillissement cognitif restent peu étudiés et encore sujets à controverse. Même si depuis plusieurs décennies, on sait que la mémoire à court terme verbale des personnes trisomiques 21 est déficitaire, son fonctionnement exact et les conséquences de ce déficit sur le développement d’autres domaines comme le langage oral et la lecture restent relativement peu explorés en regard des nombreuses études descriptives sur les déficits observés dans la maîtrise langage oral. A l'heure ou l'inclusion des personnes atteintes d'une déficience intellectuelle devient une pratique de plus en plus courante et recommandée, il semble essentiel d'approfondir notre connaissance du développement cognitif de ces personnes de manière à mettre en place des moyens adaptés au sein des classes et de potentialiser apprentissages. Par ailleurs, la problématique du vieillissement et plus particulièrement de l’incidence de la maladie d’Alzheimer est devenue, de par l’espérance de vie accrue des personnes trisomiques 21, un sujet de recherche de plus en plus développé. [less ▲]

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See detailL’animation à l’épreuve de la danse : Norman McLaren ou la conquête du chorégraphique
Tomasovic, Dick ULg

Conference (2017, March 17)

Figuremajeure du cinéma d’animation artisanal et expérimental, Norman McLaren, à travers l’apprentissage de multiples techniques d’animation (dessin animé, stop motion, pixillation, pellicule peinte ou ... [more ▼]

Figuremajeure du cinéma d’animation artisanal et expérimental, Norman McLaren, à travers l’apprentissage de multiples techniques d’animation (dessin animé, stop motion, pixillation, pellicule peinte ou grattée, expositions multiples...) n’a cessé d’étudier le mouvement. Si le cinéaste a, d’une part, émis un certain nombre de rapprochements entre la figure de l’animateur et celle du danseur, et, d’autre part, livré une œuvre qui fait date dans l’histoire du film de danse (le célèbre Pas de deux, 1968), c’est à une question moins apparente sur les liens entre danse et cinéma que cette intervention souhaite s’intéresser. En effet, à travers le commentaire d’une série de films conçus entre 1935 et 1972, il s’agira de comprendre de quelle manière la conception même du geste animé chez McLaren s’inscrit, dès ses prémisses, dans une logique d’invention chorégraphique. [less ▲]

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See detailLes produits "sans", pas sains ? Quelle composition modifiée ?
Sindic, Marianne ULg

Conference (2017, March 17)

Sans lait, sans sucre, sans gluten. De plus en plus de personnes choisissent d'écarter un aliment de leur alimentation. Face à cette demande, la distribution présente un large choix d’aliments modifiés ... [more ▼]

Sans lait, sans sucre, sans gluten. De plus en plus de personnes choisissent d'écarter un aliment de leur alimentation. Face à cette demande, la distribution présente un large choix d’aliments modifiés pour répondre aux courants à la mode « sans ». Mais hors cas avéré d'intolérance, ces évictions ont elles un intérêt médical ? Longtemps réservés à une population particulière, les produits sans gluten connaissent depuis quelques années un très large développement. Parmi les lancements de produits référencés dans la base de données Mintel GNPD, le pourcentage de produits revendiquant l’absence de gluten était inférieur à 1% en 2000 pour passer à 5% en 2010 et dépasser les 10% en 2015 (Chéné et al, 2015). Difficile de dire s’il s’agit d’un phénomène de mode lié à des «recommandations » par des personnes célèbres du cinéma ou du sport qui vantent les mérites d’un régime sans gluten sur leur bien-être. Mais qu’en est-il de la qualité de ces produits ? Dans une étude récente, Wu et al ont comparé la composition de plus de 3000 produits avec ou sans gluten répartis en 10 catégories. La qualité globale des produits sans gluten est nutritionnellement plus faible avec des niveaux plus élevés en sucres, graisses saturées et sel. En effet, remplacer le gluten dont les propriétés techno fonctionnelles et sensorielles sont importantes n’est pas aisé. Les sources les plus utilisées pour remplacer le blé sont le riz et le maïs mais d’autres sources plus originales sont parfois utilisées comme le lin, l’amaranthe ou le chia en complétant avec des additifs texturants (dérivés de cellulose, guar, xanthane,…). L’ajout de sucre ou graisses vient renforcer l’appréciation sensorielle. Dans une revue publiée en 2016 par Vici et al, on notera également un plus faible taux de fibres, vitamines et minéraux en particulier les folates, vitamines B12, D, calcium, fer, zinc et manganèse dans une alimentation « gluten-free ». Face à ce constat, il convient de s’interroger sur ces régimes « NO GLU » alors que des médecins annoncent que 90% des gens qui font un régime sans gluten le font sans raison valable. De même, le boycott pur et simple de l’huile de palme tel qu’il est encouragé par certains groupes activistes ne peut pas constituer une réponse adéquate au problème. En effet, si l’huile de palme doit être supprimée des produits, elle pourrait être remplacée par une autre matière grasse comme par exemple l’huile de palmiste (huile extraite du noyau du fruit du palmier à huile) ou de coprah (huile extraite de la pulpe de noix de coco) qui présentent un contenu encore plus important en acides gras saturés (surtout l’acide laurique et l’acide myristique). Technologiquement, les possibilités de substitution sont actuellement peu nombreuses, et présentent toutes des inconvénients majeurs, qu’ils soient nutritionnels ou environnementaux. C’est au travers de ces quelques exemples que la formulation d’aliments « sans » sera discutée en évoquant les risques potentiels pour la santé. [less ▲]

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See detailMusique et plaisanterie. Ethnographie de trois groupes sociaux (coolooji, ñeeñɓe et mbiruuji) à Djéwol (Mauritanie)
Sow, Aboubakry ULg

Doctoral thesis (2017)

The village of Djéwol (Mauritania) is located on the right bank of the Sénégal river and its' population is estimated to approximately 9000 inhabitants that are split to two communities, the Haalpulaar ... [more ▼]

The village of Djéwol (Mauritania) is located on the right bank of the Sénégal river and its' population is estimated to approximately 9000 inhabitants that are split to two communities, the Haalpulaar and the Soninké who are organinized into hierarchies. Straddling on both communities are the ñeeñɓe (social mediators) and the riimayɓe (servants), who are the main producers and actors of music. Although sometimes they declare themselves to be Haalpulaar, other times, they call themselves Soninké, mainly because of bilingualism and versatility of their music. For this reason, the ñeeñɓe and riimayɓe are conveyed to all manifestations and festivities that punctuate the life of the village. On such occasions, other genres of music are also played by coolooji (social protesters) and the mbiruuji (fighters), both of these being marginal subclasses who are constantly in conflict with the ñeeñɓe. Based on my position of researcher/musian/haalpulaar/dimo (noble) originating from this village and on my personal journey, while using a reflexive method, I will question the rôle and the place in the society of the three actors previously mentioned : The coolooji, the ñeeñɓe and the mbiruuji. Starting with an ethnological description and an anthropological analysis of the different operating modes of yano (pleasantry procedure) – which allow the denɗiraagal (similar to pleasantry) to be set into motion or not – in their articulation of music, it will be a matter of asking ourselves in which way the the coolooji, the ñeeñɓe and the mbiruuji define themselves and contribute to defining others through yano and music. Thus, the first part of this thesis suggests, beyond the presentation of the historical and social context of the community and Djéwol village, adopting a synoptic perspective on the Haalpulaar and Soninké music of the region near the Sénégal river. The second part, however, will focus on the origin of the different types of relations in jiidugal (kin) and of denɗiraagal (related of pleasantry) which proceed by using the yano, as well as the musical art associated with the later. Finally, the last part will be dedicated to analyzing the interactions, conflicting or not, as well as the absence of interactions between the coolooji, the ñeeñɓe and the mbiruuji while highlighting the similarities and the differences between these three significant figures. In conclusion, the situation will be analyzed in the light of the contemporary reconfigurations and of the evolution of the bounds tied between the denɗiraagal and the surrounding social networks. Le village de Djéwol (Mauritanie) se situe sur la rive droite du fleuve Sénégal et compte aujourd’hui 9000 habitants se répartissant en deux communautés, haalpulaar et soninké, fortement hiérarchisées en leur sein. À cheval sur les deux communautés, se trouvent les ñeeñɓe (médiateurs sociaux) et les riimayɓe (serviteurs) qui sont les principaux producteurs et acteurs de musique. Ceux-ci se déclarent tantôt haalpulaar tantôt soninké, notamment en raison de leur bilinguisme et de la polyvalence de leurs musiques. À ce titre, les ñeeñɓe et les riimayɓe sont conviés à toutes les manifestations et festivités qui rythment la vie du village. En ces occasions, d’autres genres de musiques sont également pratiqués par les coolooji (contestataires sociaux) et les mbiruuji (lutteurs), deux « sous-groupes marginaux » qui sont constamment en conflit avec les ñeeñɓe. En m’appuyant, de manière réflexive, sur ma position de chercheur/musicien/haalpulaar/dimo (noble) originaire du village et sur mon parcours, j’interrogerai le rôle et la place dans la société de trois des acteurs mentionnés : les coolooji, les ñeeñɓe et les mbiruuji. À partir de la description ethnographique et de l’analyse anthropologique des divers modes opératoires du yano (procédé de plaisanterie) – qui permettent d’activer ou de désactiver le denɗiraagal, parenté à plaisanterie – dans leur articulation avec la musique, il s’agira de se demander de quelle manière les coolooji, les ñeeñɓe et les mbiruuji se définissent et contribuent à définir autrui à travers le yano et la musique. Ainsi, la première partie de cette thèse proposera, au-delà de la présentation du contexte historique et social de la commune et du village de Djéwol, un regard synoptique sur les musiques haalpulaar et soninké de la région du fleuve Sénégal. La deuxième partie s’intéressera quant à elle à l’origine des différents types de parenté jiidugal (parenté) et de denɗiraagal (parenté à plaisanterie) procédant par le yano, ainsi qu’à l’art musical associé à ce dernier. Enfin, la dernière partie, consacrée à l’analyse des interactions, conflictuelles ou non, et de l’absence d’interactions entre les coolooji, les ñeeñɓe, et les mbiruuji, mettra en évidence les similitudes et les différences entre ces trois figures. La situation sera finalement analysée à la lumière des reconfigurations contemporaines et de l’évolution des liens de denɗiraagal sur les réseaux sociaux. [less ▲]

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See detailModulation of NMDA receptor mediated excitatory synaptic currents in dopamine neurons of the substantia nigra.
Destreel, Geoffrey ULg; Seutin, Vincent ULg; Engel, Dominique ULg

Poster (2017, March 17)

Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) exhibit two main firing modes, spontaneous single action potential (AP) firing and bursting. The amount of DA released by these neurons in ... [more ▼]

Dopamine (DA) neurons of the substantia nigra pars compacta (SNc) exhibit two main firing modes, spontaneous single action potential (AP) firing and bursting. The amount of DA released by these neurons in target areas depends on the presynaptic AP firing pattern and is essential to modulate several aspects of behavior such as the control of movement. Bursting activity is mediated by excitatory afferents and specifically by the activation of NMDA receptors (NMDARs). However, the level of activation of NMDARs at these synapses during spontaneous synaptic activity is unknown. We assessed the occupancy of the glycine binding sites of the NMDAR by testing the effects of coagonists and by blocking the uptake of glycine on spontaneous excitatory postsynaptic currents (sEPSCs) in DA neurons of the SNc. Parasagittal midbrain slices (300 – 350 µm thickness) were cut from the brains 16- to 26- days old Wistar rats using a vibratome. Whole-cell recordings were made using warm (~35C°) standard artificial cerebrospinal fluid. sEPSCs were pharmacologically isolated and recorded at +40 and -70 mV. A large NMDAR-sEPSC component was present at +40 mV as revealed by the application of 50 µM D-AP5 (n=8, P < 0.001). At -70 mV, D-AP5 had no effect on the EPSC, as expected (n=7, P = 0.52). The mean amplitude of the average NMDAR sEPSC measured at +40 mV increased significantly from 8.6 ± 0.8 pA in control conditions to 10.9 ± 1.0 pA during bath application of 300 μM glycine (n=10, P < 0.001). We also investigated the effect of D-serine, the other coagonist at the NMDAR glycine site. The mean NMDAR EPSC amplitude measured at +40 mV showed a tendency toward larger values, from 6.8 ± 0.8 pA in control conditions to 8.8 ± 1.1 pA in the presence of 100 µM D-serine (n=4). Blockade of the glycine transporter-1 (GlyT1) significantly increased the mean amplitude of NMDAR sEPSCs measured at +40 mV from 7.1 ± 0.5 pA in control conditions to 10.5 ± 0.8 pA in the presence of 5 μM NFPS (n=8, P < 0.001). At -70 mV, NFPS had no effect on the AMPAR-sEPSC component, as expected (n=8, P = 0.23). In conclusion, our results indicate that the NMDAR glycine sites are not saturated by glycine and D-serine during sEPSCs in control conditions. [less ▲]

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See detailMulti-instrument overview of the 1-hour pulsations in Saturn's magnetosphere
Palmaerts, Benjamin ULg; Roussos, Elias; Radioti, Aikaterini ULg et al

Conference (2017, March 16)

Detailed reference viewed: 17 (2 ULg)