Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailThiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stressinduced behaviours in mice
Markova, Nataliia; Bazhenova, Nataliya; Anthony, Daniel C et al

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (2017), 75

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling ... [more ▼]

Thiamine deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)-3β. While decreased GSK- 3β activity appears to impair memory, increased GSK-3β activity is associated with the distressed/depressed state. However, direct evidence for the effects of thiamine on GSK-3β function were not have not been reported. Here, we administered thiamine or, the more bioavailable precursor, benfotiamine at 200 mg/kg/day for 2 weeks to C57BL/6J mice, to determine whether treatment might affect behaviours that are known to be sensitive to GSK-3β activity and whether such administration impacts on GSK-3β expression within the brain. The mice were tested in models of contextual conditioning and extinction, a 5-day rat exposure stress test, and a modified swim test with repeated testing. Imipramine (7.5 mg/kg/day) was administered as a positive control for thiamine or benfotiamine. As for imipramine, both compounds inhibited the upregulation of GSK-3β induced by predator stress or repeated swimming, and reduced floating scores and the predator stress-induced behavioural changes in anxiety and exploration. Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step-down avoidance task. Together, our data indicate that thiamine and benfotiamine have antidepressant/anti-stress effects in naïve animals that are associated with reduced GSK-3β expression. Importantly, the treatment also had pro-cognitive actions despite the impact on GSK-3β activity. [less ▲]

Detailed reference viewed: 37 (8 ULg)
See detailThiamine: Biological forms and function
Bettendorff, Lucien ULg

Conference (2017)

Detailed reference viewed: 25 (0 ULg)
Full Text
Peer Reviewed
See detailMechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation
Mitrossilis, Démosthène; Röper, Jens-Christian; Roy, Damien Le et al

in Nature Communications (2017), 8

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also ... [more ▼]

Animal development consists of a cascade of tissue differentiation and shape change. Associated mechanical signals regulate tissue differentiation. Here we demonstrate that endogenous mechanical cues also trigger biochemical pathways, generating the active morphogenetic movements shaping animal development through a mechanotransductive cascade of Myo-II medio-apical stabilization. To mimic physiological tissue deformation with a cell scale resolution, liposomes containing magnetic nanoparticles are injected into embryonic epithelia and submitted to time-variable forces generated by a linear array of micrometric soft magnets. Periodic magnetically induced deformations quantitatively phenocopy the soft mechanical endogenous snail-dependent apex pulsations, rescue the medio-apical accumulation of Rok, Myo-II and subsequent mesoderm invagination lacking in sna mutants, in a Fog-dependent mechanotransductive process. Mesoderm invagination then activates Myo-II apical accumulation, in a similar Fog-dependent mechanotransductive process, which in turn initiates endoderm invagination. This reveals the existence of a highly dynamic self-inductive cascade of mesoderm and endoderm invaginations, regulated by mechano-induced medio-apical stabilization of Myo-II. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailA surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)
Farhat, Khalil; Bodart, Gwennaelle; Martens, Henri ULg et al

in Neuroimmunomodulation (2017)

Detailed reference viewed: 29 (5 ULg)
See detailBenchmark et analyse des écarts pour la planification d'urgence externe relative au risque Seveso
Thiry, Aline ULg; Verhaegen, Marlies; Fallon, Catherine ULg et al

Report (2017)

La recherche commanditée par le SPF Intérieur a mobilisé différentes méthodologies: au total près de 200 acteurs industriels et acteurs publics - de la planification d’urgence et de la gestion de ... [more ▼]

La recherche commanditée par le SPF Intérieur a mobilisé différentes méthodologies: au total près de 200 acteurs industriels et acteurs publics - de la planification d’urgence et de la gestion de crise en Belgique ont été invités à participer à l’enquête à travers des entretiens et un questionnaire Mesydel en ligne. Un benchmark a également été effectué dans 5 pays voisins à l’aide de questionnaires écrits et d’entretiens téléphoniques. L’objectif a été de mettre en évidence les difficultés rencontrées en matière de planification d’urgence externe pour les entreprises Seveso seuil haut en Belgique et d’identifier les (bonnes) pratiques dans les pays voisins. [less ▲]

Detailed reference viewed: 18 (3 ULg)
See detailFrançois Ier et les arts du Nord (1515-1547). Des liens à explorer et à appronfondir encore
Fagnart, Laure ULg; Lecocq, Isabelle

in Fagnart, Laure; Lecocq, Isabelle (Eds.) François Ier et les arts du Nord (1515-1547) (2017)

Detailed reference viewed: 28 (3 ULg)
See detailJean Clouet vs Joos van Cleve
Fagnart, Laure ULg

in Fagnart, Laure; Lecocq, Isabelle (Eds.) François Ier et les arts du Nord (1515-1547) (2017)

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailThe closure of arteriovenous fistula in kidney transplant recipients is associated with an acceleration of kidney function decline
WEEKERS, Laurent ULg; VANDERWECKENE, Pauline ULg; pottel, hans et al

in Nephrology Dialysis Transplantation (2017)

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney ... [more ▼]

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney transplant recipients (KTRs) remains unknown. Methods. From 2007 to 2013, we retrospectively categorized 285 KTRs into three groups: no AVF (Group 0, n = 90), closed AVF (Group 1, n = 114) and left-open AVF (Group 2, n = 81). AVF closure occurred at 653 ± 441 days after kidney transplantation (KTx), with a thrombosis:ligation ratio of 19:95. Estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Disease equation. Linear mixed models calculated the slope and intercept of eGFR decline versus time, starting at 3 months post-KTx, with a median follow-up of 1807 days (95% confidence interval 1665–2028). Results. The eGFR slope was less in Group 1 (−0.081 mL/min/ month) compared with Group 0 (−0.183 mL/min/month; P = 0.03) or Group 2 (−0.164 mL/min/month; P = 0.09). Still, the eGFR slope significantly deteriorated after (−0.159 mL/min/month) versus before (0.038 mL/min/month) AVF closure (P= 0.03). Study periods before versus after AVF closure were balanced to a mean of 13.5 and 12.5 months, respectively, with at least 10 observations per patient (n = 99). Conclusions. In conclusion, a significant acceleration of eGFR decline is observed over the 12 months following the closure of a functioning AVF in KTRs. [less ▲]

Detailed reference viewed: 41 (12 ULg)
Full Text
Peer Reviewed
See detailThe Epoch of Smart Cities and Innovation.
Crutzen, Nathalie ULg; Marolla, Cesar

in Marolla, Cesar (Ed.) Climate Health Risks in Megacities: Sustainable Management and Strategic Planning (2017)

Detailed reference viewed: 26 (4 ULg)
Full Text
Peer Reviewed
See detailTopography and Lateralized Effect of Acute Aromatase Inhibition on Auditory Processing in a Seasonal Songbird
de groof, Geert; Balthazart, Jacques ULg; Cornil, Charlotte ULg et al

in Journal of Neuroscience (2017), 37(16), 4243-4254

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of ... [more ▼]

It is increasingly recognized that brain-derived estrogens (neuroestrogens) can regulate brain physiology and behavior much faster than what was previously known from the transcriptional action of estrogens on nuclear receptors. One of the best examples of such neuro- modulation by neuroestrogens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electrophys- iological studies of selected neurons in zebra finches. Yet, the spatial extent of such modulation by neuroestrogens is not known. Using functional magnetic resonance imaging, we demonstrate here that acute estrogen depletion alters within minutes auditory processing in male European starlings. These effects are confined to very specific but large areas of the auditory cortex. They are also specifically lateralized to the left hemisphere. Interestingly, the modulation of auditory responses by estrogens was much larger (both in amplitude and in topography) in March than in December or May/June. This effect was presumably independent from changes in circulating testosterone concentrations since levels of the steroid were controlled by subcutaneous implants, thus suggesting actions related to other aspects of the seasonal cycle or photoperiodic manipulations. Finally, we also show that estrogen production specifically modulates selectivity for behaviorally relevant vocalizations in a specific part of the caudomedial nidopallium. These findings confirm and extend previous conclusions that had been obtained by electrophysiological techniques. This approach provides a new very powerful tool to investigate auditory responsiveness in songbirds and its fast modulation by sex steroids. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailPost-scriptum à La Misère du monde 25 ans après : Bourdieu, le peuple et son suicide
Cormann, Grégory ULg

in Provenzano, François; Goin, Emilie (Eds.) Usages du peuple (2017)

Detailed reference viewed: 76 (16 ULg)
Full Text
Peer Reviewed
See detailBrentano on Appearance and Reality
Seron, Denis ULg

in Kriegel, Uriah (Ed.) The Routledge Handbook of Franz Brentano and the Brentano School (2017)

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailIron-dependent nitrogen cycling in a ferruginous lake and the nutrient status of Proterozoic oceans
Michiels, Celine C.; Darchambeau, François ULg; Roland, Fleur ULg et al

in Nature Geoscience (2017), advance online publication

Nitrogen limitation during the Proterozoic has been inferred from the great expanse of ocean anoxia under low-O2 atmospheres, which could have promoted NO3- reduction to N2 and fixed N loss from the ocean ... [more ▼]

Nitrogen limitation during the Proterozoic has been inferred from the great expanse of ocean anoxia under low-O2 atmospheres, which could have promoted NO3- reduction to N2 and fixed N loss from the ocean. The deep oceans were Fe rich (ferruginous) during much of this time, yet the dynamics of N cycling under such conditions remain entirely conceptual, as analogue environments are rare today. Here we use incubation experiments to show that a modern ferruginous basin, Kabuno Bay in East Africa, supports high rates of NO3- reduction. Although 60 of this NO3- is reduced to N2 through canonical denitrification, a large fraction (40\%) is reduced to NH4+, leading to N retention rather than loss. We also find that NO3- reduction is Fe dependent, demonstrating that such reactions occur in natural ferruginous water columns. Numerical modelling of ferruginous upwelling systems, informed by our results from Kabuno Bay, demonstrates that NO3- reduction to NH4+ could have enhanced biological production, fuelling sulfate reduction and the development of mid-water euxinia overlying ferruginous deep oceans. This NO3- reduction to NH4+ could also have partly offset a negative feedback on biological production that accompanies oxygenation of the surface ocean. Our results indicate that N loss in ferruginous upwelling systems may not have kept pace with global N fixation at marine phosphorous concentrations (0.04-0.13[thinsp][mu]M) indicated by the rock record. We therefore suggest that global marine biological production under ferruginous ocean conditions in the Proterozoic eon may thus have been P not N limited. [less ▲]

Detailed reference viewed: 33 (2 ULg)
Full Text
See detailListe des signes sumériens d'après le "manuel d'épigraphie akkadienne" R. Labat- F. Malbran-Labat
Colonna d'Istria, Laurent ULg

Learning material (2017)

Liste des signes sumériens d'après le "manuel d'épigraphie akkadienne" R. Labat- F. Malbran-Labat

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailA look at Intact Forest Landscapes and their relevance in Central African forest policy
Haurez, Barbara ULg; Daïnou, Kasso ULg; Vermeulen, Cédric ULg et al

in Forest Policy and Economics (2017), 80

Tropical forests are major providers of natural resources and ecosystem services but their ecological functions are at threat, due to increasing human pressure linked to economic development. The ... [more ▼]

Tropical forests are major providers of natural resources and ecosystem services but their ecological functions are at threat, due to increasing human pressure linked to economic development. The identification of priority areas for conservation is crucial for land use planning to ensure the protection of biodiversity and ecological function. Intact Forest Landscapes (IFLs), as defined by Greenpeace and World Resources Institute (WRI), are areas of the forest ecosystems not subjected to human activities. They have beenidentified by mapping human disturbances through remote sensing. Contrary to similar global-scale concepts, IFLs have been integrated into the standards of the certification body Forest Stewardship Council (FSC) and therefore have practical implications for forest management policies. The Motion 65, approved in the general assembly of FSC in 2014, mandates the protection of IFLs located in FSC certified logging concessions. Until the implementation of national standards, forestry operations are banished from 80% of the IFL area within each forest management unit. To trace the history and evaluate the suitability of IFLs in the Central African context, we searched for documents related to the IFL method, and related approaches focusing on the identification of areas devoid of human disturbances. The IFL method is simple and cost-effective and allows for a global assessment of the influence of human infrastructures and industrial exploitation on forests However, the method does not consider the situation below the canopy and those forest components not visible by satellites. For example, hunting, one of the main threats faced by wildlife in Central African forests today, cannot be detected with satellite imagery. On the other hand, other anthropogenic activities which remote sensing may detect may be compatible with forest ecosystem conservation. To better tailor the IFL approach to Central African forests, we recommend (i) the consideration of wildlife communities in the intactness analysis, (ii) a thorough evaluation of the impacts of human activities on forest ecosystems, and (iii) the integration of local stakeholders and governments in the design of land management strategies to respond to social, economic and environmental needs [less ▲]

Detailed reference viewed: 29 (12 ULg)
Full Text
Peer Reviewed
See detailOptimized approach to retrieve information on atmospheric carbonyl sulfide (OCS) above the Jungfraujoch station and change in its abundance since 1995
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Vollmer, M. K. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2017), 186

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss ... [more ▼]

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss Alps. More than 200 lines of the nu3 fundamental band of OCS have been systematically evaluated and we selected 4 microwindows on the basis of objective criteria minimizing the effect of interferences, mainly by solar features, carbon dioxide and water vapor absorption lines, while maximizing the information content. Implementation of this new retrieval strategy provided an extended time series of the OCS abundance spanning the 1995-2015 time period, for the study of the long-term trend and seasonal variation of OCS in the free troposphere and stratosphere. Three distinct periods characterize the evolution of the tropospheric partial columns: a first decreasing period (1995-2002), an intermediate increasing period (2002-2008), and the more recent period (2008-2015) which shows no significant trend. Our FTIR tropospheric and stratospheric time series are compared with new in situ gas chromatography mass spectrometry (GCMS) measurements performed by Empa (Laboratory for Air Pollution/Environmental Technology) at the Jungfraujoch since 2008, and with space-borne solar occultation observations by the ACE-FTS instrument on-board the SCISAT satellite, respectively, and they show good agreement. The OCS signal recorded above Jungfraujoch appears to be closely related to anthropogenic sulfur emissions. [less ▲]

Detailed reference viewed: 92 (27 ULg)
Full Text
Peer Reviewed
See detailEntrepreneurial teams in social entrepreneurship: When team heterogeneity facilitates organizational hybridity
Dufays, Frédéric ULg; Huybrechts, Benjamin ULg

in Ben-Hafaïedh, Cyrine; Cooney, Thomas (Eds.) Research handbook on entrepreneurial teams: Theory and practice (2017)

This chapter examines the composition of teams involved in social entrepreneurship and more particularly their heterogeneity in terms of “institutional logics”. It proposes that when social welfare and ... [more ▼]

This chapter examines the composition of teams involved in social entrepreneurship and more particularly their heterogeneity in terms of “institutional logics”. It proposes that when social welfare and market logics are integrated within founding teams, such hybridity is likely to infuse the whole entrepreneurial process to ultimately lead to the creation of a social enterprise as a “hybrid” organization. To theorize this process, a model is proposed that examines the implications of entrepreneurial team heterogeneity in social entrepreneurship. It makes clear that complexity and dynamism, in particular with regard to individuals’ social network structure, as well as interactions between team members, are necessary to understand the impact of team composition on the entrepreneurial process. An illustrative case study is presented to demonstrate the practical relevance of the model. [less ▲]

Detailed reference viewed: 67 (4 ULg)
Full Text
See detailIntroduction
Masson, Christophe ULg

E-print/Working paper (2017)

Introduction de l'Assemblée générale de Ménestrel – 35e journée d'étude du Réseau des Médiévistes belges de Langue française. Le Moyen Âge dans les (nouveaux) médias. Quelle place pour les médiévistes  ... [more ▼]

Introduction de l'Assemblée générale de Ménestrel – 35e journée d'étude du Réseau des Médiévistes belges de Langue française. Le Moyen Âge dans les (nouveaux) médias. Quelle place pour les médiévistes ? Université de Liège, 7-8 octobre 2016 [less ▲]

Detailed reference viewed: 12 (0 ULg)