Questions à Dominique Pradelle ("Par-delà la révolution copernicienne")

Speech (2012)

Discussion of D. Pradelle, "Par-delà la révolution copernicienne. Sujet transcendantal et facultés chez Kant et Husserl" (Paris, PUF, 2012).

Ateliers "L'activité un prisme multifacettes": L'institution, fin de la vie active ?

Conference (2012, December 11)

En attendant la fin des temps: deux espèces d'apocalypticiens

Article for general public (2012)

A l'approche de la date fatidique du 21 décembre 2012, l'article revient sur la posture "catastrophiste" en insistant sur le rôle de la fiction et de l'imagination dans nos stratégies collectives d ... [more ▼]

A l'approche de la date fatidique du 21 décembre 2012, l'article revient sur la posture "catastrophiste" en insistant sur le rôle de la fiction et de l'imagination dans nos stratégies collectives d'évitement du pire. Assimilés à tort aux prophètes de malheur, les auteurs de dystopie comme Orwell ou Huxley ne nous décrivent l'avènement d'une menace que pour mieux la conjurer. Sans cette espèce d' "apocalypticiens prophylactiques", comme se décrivait Günther Anders, il est probable que notre capacité à penser la catastrophe serait sérieusement atrophiée. [less ▲]

GRH et Organisation du travail dans les centres d'appels délocalisés au Maroc

Doctoral thesis (2012)

Considered, rightly or wrongly, as "new factories of the future", call centers generate more interest for both researchers and professionals. Their human aspects in general and their HR practices in ... [more ▼]

Considered, rightly or wrongly, as "new factories of the future", call centers generate more interest for both researchers and professionals. Their human aspects in general and their HR practices in particular is a rich field for investigations, due to the importance of their technical and social systems in their performance or their sustainability. The question of the choice of HR practices is the focus of this work devoted to the issue of HRM and work organization in offshoring call centers. It is based on nine case studies representing a varied typology of Moroccan call centers sector and three typical -ideal models adopted by them (Hard, Soft or hybrid). The choice of a model or another comes, initially, from a business strategy, a targeted market segment and a given level of outsourced value-added activities. The alignment between strategy and organization of the call center operates for each model to incorporate the same operational requirements (customer-agent interactions, colleagues) and its internal labor market. This variable is the link between work organization and HR strategy adopted. Referring to an HR model or another is conditioned by the intervention of the principal who greatly influence the decisions of managers as well as decision makers. [less ▲]

Capacité d'ingestion et variation des réserves corporelles chez la vache laitière au cours de la lactation

Conference given outside the academic context (2012)

Characterization of chemotherapy-induced cell death in glioblastoma

Poster (2012, December 10)

Glioblastoma constitute the most frequent and deadliest type of brain tumors. Their annual incidence is estimated between 5 and 8 cases per 100,000 people in Europe and North America. They are resistant ... [more ▼]

Glioblastoma constitute the most frequent and deadliest type of brain tumors. Their annual incidence is estimated between 5 and 8 cases per 100,000 people in Europe and North America. They are resistant to all current therapies and are associated with a very high rate of recurrence. The associated prognosis is generally very poor and most patients die within a year after diagnosis. Unfortunately, despite extensive research and use of multimodality treatments combining surgical resection, chemotherapy and radiotherapy, survival hasn’t really much improved over the last 20 years. Indeed, these tumors were shown to be characterized by a high radio- and chemo-resistance. Glioblastoma cells exhibit overexpression of the anti-apoptotic Bcl-2 family proteins and downregulation of its pro-apoptotic members, high expression of the IAPs (Inhibitors of Apoptosis Proteins) and constitutive activation of the pro-survival NF-κB pathway. Currently, the most commonly used treatment offering the best prognosis to patients consists in a combination of maximal surgical tumor resection (when feasible) with subsequent radio- and/or chemotherapy. Among the most commonly used chemotherapeutic agents, the alkylating agent temozolomide and the topoisomerase I inhibitor camptothecin occupy a central position. Therefore, in this study, the impact of both temozolomide and irinotecan (a soluble derivative of camptothecin) on glioma cell survival will be investigated. Important progress was made in the comprehension of the molecular mechanisms underlying tumor development and progression however, survival benefits conferred by the use of new drugs and therapeutic strategies are counted in months rather than years. Consequently, there is an urge to rapidly improve the efficiency of the currently used treatments. This research project consists in (i) the study of the mechanisms implicated in glioblastoma cell death induced by two chemotherapeutic agents : temozolomide and irinotecan, (ii) the identification of the mechanisms underlying the resistance of glioblastoma to these treatments, (iii) the use of pharmacological tools to interfere with those resistance strategies to enhance chemotherapy efficiency. Necrosis was, until recently, long thought to be only accidental. However, it was shown to be finely regulated by specific signalling pathways. Programmed necrosis often takes place in cells in which apoptosis cannot be properly activated and serves as a back-up cell death pathway. Previous work from our lab having already demonstrated that glioblastoma are, at least partially, apoptosis-defective, special emphasis is put on the study of necrotic parameters. Results from survival tests performed on several glioblastoma cell lines in the presence of necrotic inhibitors like necrostatin-1 (an inhibitor of the central regulator of the necrotic pathway RIP1) allows to partially overcome temozolomide and irinotecan-induced glioblastoma cell death, highlighting the role played by programmed necrosis in chemotherapy sensitivity. [less ▲]

In vitro and in vivo Characterization of Adult Bone Marrow Neural Crest Stem Cells and their Implication in Hematopoietic Support

Poster (2012, December 10)

Role of γδ T cells in HPV-induced cancer progression

Poster (2012, December 10)

Oncogenic human papillomavirus could directly interact with Natural Killer cells

Poster (2012, December 10)

Mise en perspective de l'état de vulnérabilité alimentaire au Niger

Scientific conference (2012, December 10)

Cette présentation lors d'un séminaire tente de faire l'état des lieux de la sécurité alimentaire au Niger. Elle aborde la sécurité alimentaire à travers deux indices composites fortement axés sur la ... [more ▼]

Cette présentation lors d'un séminaire tente de faire l'état des lieux de la sécurité alimentaire au Niger. Elle aborde la sécurité alimentaire à travers deux indices composites fortement axés sur la disponibilité et l'accessibilité alimentaire. Elle identifie leurs limites et avantages ainsi que leurs potentiels face à de futures recherches. [less ▲]