Last 7 days
Bookmark and Share    
Full Text
Peer Reviewed
See detailDifferentiation of patented crystalline glucosamine sulfate from other glucosamine preparations will optimize osteoarthritis treatment.
Saengnipanthkul, Sukit; Waikakul, Saranatra; Rojanasthien, Sattaya et al

in International Journal of Rheumatic Diseases (2017)

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and ... [more ▼]

Symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) are recommended for the medium- to long-term management of knee osteoarthritis (OA) due to their abilities to control pain, improve function and delay joint structural changes. Among SYSADOAs, evidence is greatest for the patented crystalline glucosamine sulfate (pCGS) formulation (Mylan). Glucosamine is widely available as glucosamine sulfate (GS) and glucosamine hydrochloride (GH) preparations that vary substantially in molecular form, pharmaceutical formulation and dose regimen. Only pCGS is given as a highly bioavailable once-daily dose (1500 mg), which consistently delivers the plasma levels of around 10 mumol/L required to inhibit interleukin-1-induced expression of genes involved in the pathophysiology of joint inflammation and tissue destruction. Careful consideration of the evidence base reveals that only pCGS reliably provides a moderate effect size on pain that is higher than paracetamol and equivalent to non-steroidal anti-inflammatory drugs (NSAIDs), while non-crystalline GS and GH fail to reach statistical significance for pain reduction. Chronic administration of pCGS has disease-modifying effects, with a reduction in need for total joint replacement lasting for 5 years after treatment cessation. Pharmacoeconomic studies of pCGS demonstrate long-term reduction in additional pain analgesia and NSAIDs, with a 50% reduction in costs of other OA medication and healthcare consultations. Consequently, pCGS is the logical choice, with demonstrated medium-term control of pain and lasting impact on disease progression. Physician and patient education on the differentiation of pCGS from other glucosamine formulations will help to improve treatment selection, increase treatment adherence, and optimize clinical benefit in OA. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailOsteoporosis in Frail Patients: A Consensus Paper of the Belgian Bone Club.
Gielen, E.; Bergmann, P.; Bruyère, Olivier ULg et al

in Calcified Tissue International (2017)

In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia ... [more ▼]

In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old. All these conditions may indeed induce bone loss that is superimposed on physiological bone loss and often remains under-recognized and under-treated. This is of particular concern because of the major burden of osteoporotic fractures in terms of morbidity, mortality, and economic cost. Therefore, there is an urgent need to appreciate bone loss associated with these conditions, as this may improve diagnosis and management of bone loss and fracture risk in clinical practice. [less ▲]

Detailed reference viewed: 14 (4 ULg)
Full Text
Peer Reviewed
See detailMultidisciplinary rehabilitation program after breast cancer: benefits on physical function, anthropometry and quality of life.
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; Tomasella, Marco ULg et al

in European Journal of Physical and Rehabilitation Medicine (2017)

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered ... [more ▼]

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program has been little studied so far. AIM: To determine the benefits of a three-month multidisciplinary rehabilitation program among women after breast cancer treatment. DESIGN: Controlled no-randomized trial. SETTING: University for outcomes, University Hospital Center for interventions. POPULATION: Two hundred and nine outpatients who have been treated for a primary breast carcinoma. METHODS: Patients were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a rehabilitation program of three months including physical training and psycho-educational sessions. The assessments, performed before and after the program, included functional assessments ("Sit and Reach Test", maximal incremental exercise test and "Six-Minute Walk Test"), body composition measurements (body mass index (BMI) and body fat percentage) and a questionnaire (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30). RESULTS: After three months, flexibility, walking distance and all parameters measured during the maximal incremental exercise, except maximal heart rate, were significantly improved in the experimental group. The body fat percentage was significantly decreased and a significant improvement was observed for perceived health status (quality of life), functional role, emotional state, physical, cognitive and social functions and for most symptoms. In the control group, most of these improvements didn't appear and a significant increase in BMI and body fat percentage was observed. CONCLUSIONS: This trial identifies the benefits of a well detailed multidisciplinary rehabilitation program, including physical re-conditioning and psycho-educational sessions, with important improvements in functional capacity, body composition and the majority of functions and symptoms among women after breast cancer treatment. CLINICAL REHABILITATION IMPACT: Through its results, this study could contribute to the development of hospital quality standards for oncologic rehabilitation. Physiotherapists can efficiently propose this kind of multidisciplinary rehabilitation program. [less ▲]

Detailed reference viewed: 40 (17 ULg)
Full Text
Peer Reviewed
See detailNutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
Beaudart, Charlotte ULg; Dawson, A.; Shaw, S. C. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2017)

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise ... [more ▼]

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be limited. INTRODUCTION: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. They concluded that further studies were needed to provide evidence upon which public health and clinical recommendations could be based. The purpose of the present work was to update the prior systematic review and include studies published up to October 2015. METHODS: Using the electronic databases MEDLINE and EMBASE, we identified RCTs which assessed the combined effect of exercise training and nutritional supplementation on muscle strength, muscle mass, or physical performance in subjects aged 60 years and over. Study selection and data extraction were performed by two independent reviewers. RESULTS: The search strategy identified 21 additional RCTs giving a total of 37 RCTs. Studies were heterogeneous in terms of protocols for physical exercise and dietary supplementation (proteins, essential amino acids, creatine, beta-hydroxy-beta-methylbuthyrate, vitamin D, multi-nutrients, or other). In 79% of the studies (27/34 RCTs), muscle mass increased with exercise but an additional effect of nutrition was only found in 8 RCTs (23.5%). Muscle strength increased in 82.8% of the studies (29/35 RCTs) following exercise intervention, and dietary supplementation showed additional benefits in only a small number of studies (8/35 RCTS, 22.8%). Finally, the majority of studies showed an increase of physical performance following exercise intervention (26/28 RCTs, 92.8%) but interaction with nutrition supplementation was only found in 14.3% of these studies (4/28 RCTs). CONCLUSION: Physical exercise has a positive impact on muscle mass and muscle function in healthy subjects aged 60 years and older. The biggest effect of exercise intervention, of any type, has been seen on physical performance (gait speed, chair rising test, balance, SPPB test, etc.). We observed huge variations in regard to the dietary supplementation protocols. Based on the included studies, mainly performed on well-nourished subjects, the interactive effect of dietary supplementation on muscle function appears limited. [less ▲]

Detailed reference viewed: 14 (4 ULg)
Peer Reviewed
See detailMicro-mechanical testing of magnesium based composites reinforced by carbon fibers manufactured by friction stir processing
Simar, Aude; Ryelandt, Sophie; Delannay, Francis et al

Conference (2017, February 28)

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been ... [more ▼]

Short C fibres–Mg matrix (AZ91D) composites have been produced by friction stir processing sandwiches made of a layer of C fabric stacked between two sheets of Mg alloy. The process parameters have been optimized to ensure a good fiber distribution. 3D X-ray tomography reveals that the fibers orient like onion rings. Thermal treatments have allowed to modify the flow stress level of the matrix material. Tensile testing inside the scanning electron microscope have revealed the decohesion at the fiber/matrix interface if the fibers are preferentially oriented perpendicularly to the loading direction. Modelling allows to estimate the stress needed to initiate this decohesion is about 250 MPa, i.e. appearing early in heat treated samples. To compare with different loading conditions, micro-compression and instrumented micro-indentation testing have also been performed. The consequence of the loading path on the decohesion is discussed. [less ▲]

Detailed reference viewed: 21 (2 ULg)
Peer Reviewed
See detailOptimized integration of heat storage into district heating networks fed by a biomass CHP plant.
Sartor, Kevin ULg

in Proceedings (2017, February 28)

Biomass Combined Heat and Power (CHP) plants connected to district heating networks (DHN) are recognized as a very good opportunity to increase the share of renewable sources into energy systems. However ... [more ▼]

Biomass Combined Heat and Power (CHP) plants connected to district heating networks (DHN) are recognized as a very good opportunity to increase the share of renewable sources into energy systems. However, as CHP plants are not optimized for electricity production, their operation is profitable only if a sufficient heat demand is available throughout the year. On the other hand, these plants often work for baseline operation and back-up boilers are used to supply the peak demand. To extend the use of the CHP plants and reduce costs, conventional fuel use and emissions, it is proposed to study the feasibility of using additional high temperature heat storage as retrofit of an existing CHP plant. This work is based on a simple and effective methodology that provides accurate estimations of economic, environmental and energetic performances of CHP plants connected to district heating networks. The DHN of the University in Liège (Belgium) is used as an application framework to demonstrate the effectiveness of the selected approach. The potential energy and pollutant emissions savings and resulting energy costs are estimated and the current policy limitations will be discussed. [less ▲]

Detailed reference viewed: 37 (2 ULg)
Full Text
Peer Reviewed
See detailShort-Term Local Adaptation of Historical Common Bean (Phaseolus vulgaris L.) Varieties and Implications for In Situ Management of Bean Diversity
Klaedtke, Stephanie ULg; Caproni, Leonardo; Klauck, Julia et al

in International Journal of Molecular Sciences (2017), 18

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local ... [more ▼]

Recognizing both the stakes of traditional European common bean diversity and the role farmers’ and gardeners’ networks play in maintaining this diversity, the present study examines the role that local adaptation plays for the management of common bean diversity in situ. To the purpose, four historical bean varieties and one modern control were multiplied on two organic farms for three growing seasons. The fifteen resulting populations, the initial ones and two populations of each variety obtained after the three years of multiplication, were then grown in a common garden. Twenty-two Simple Sequence Repeat (SSR) markers and 13 phenotypic traits were assessed. In total, 68.2% of tested markers were polymorphic and a total of 66 different alleles were identified. FST analysis showed that the genetic composition of two varieties multiplied in different environments changed. At the phenotypic level, differences were observed in flowering date and leaf length. Results indicate that three years of multiplication suffice for local adaptation to occur. The spatial dynamics of genetic and phenotypic bean diversity imply that the maintenance of diversity should be considered at the scale of the network, rather than individual farms and gardens. The microevolution of bean populations within networks of gardens and farms emerges as a research perspective. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
See detailLiens entre mathématiques et jeux
Bair, Jacques ULg

E-print/Working paper (2017)

Le présent travail se compose de plusieurs parties. En premier lieu, nous définissons le concept général de jeu et présentons quelques mathématiciens célèbres, de toutes époques, qui étaient (ou sont ... [more ▼]

Le présent travail se compose de plusieurs parties. En premier lieu, nous définissons le concept général de jeu et présentons quelques mathématiciens célèbres, de toutes époques, qui étaient (ou sont encore) des adeptes de jeux mathématiques. Ensuite, nous établissons une typologie des jeux mathématiques. Une deuxième partie est consacrée à l’intervention des jeux dans l’enseignement des mathématiques. Nous donnons divers avantages des activités ludiques en classe, mais également des objections relatives à leur usage à des fins pédagogiques. Nous nous demandons aussi comment sélectionner un jeu pour des élèves et exhibons des exemples concrets de jeux exploitables en classe. Ce travail se termine par une bibliographie sur le sujet, ainsi que par une annexe composée de diapositives présentées lors d’un exposé réalisé à l’Université du Luxembourg dans le cadre de la Formation Pédagogique (FOPED) : nous y décrivons brièvement différentes épreuves ludiques proposées ces dernières années à des élèves de l’enseignement secondaire en France, Belgique et au Luxembourg. [less ▲]

Detailed reference viewed: 44 (0 ULg)
Full Text
Peer Reviewed
See detailRevisiting global fossil fuel and biofuel emissions of ethane
Tzompa-Sosa, Z. A.; Mahieu, Emmanuel ULg; Franco, Bruno ULg et al

in Journal of Geophysical Research. Atmospheres (2017), 122(4), 2493--2512

Recent measurements over the Northern Hemisphere indicate that the long-term decline in the atmospheric burden of ethane (C2H6) has ended and the abundance increased dramatically between 2010 and 2014 ... [more ▼]

Recent measurements over the Northern Hemisphere indicate that the long-term decline in the atmospheric burden of ethane (C2H6) has ended and the abundance increased dramatically between 2010 and 2014. The rise in C2H6 atmospheric abundances has been attributed to oil and natural gas extraction in North America. Existing global C2H6 emission inventories are based on outdated activity maps that do not account for current oil and natural gas exploitation regions. We present an updated global C2H6 emission inventory based on 2010 satellite-derived CH4 fluxes with adjusted C2H6 emissions over the U.S. from the National Emission Inventory (NEI 2011). We contrast our global 2010 C2H6 emission inventory with one developed for 2001. The C2H6 difference between global anthropogenic emissions is subtle (7.9 versus 7.2 Tg yr−1), but the spatial distribution of the emissions is distinct. In the 2010 C2H6 inventory, fossil fuel sources in the Northern Hemisphere represent half of global C2H6 emissions and 95% of global fossil fuel emissions. Over the U.S., unadjusted NEI 2011 C2H6 emissions produce mixing ratios that are 14–50% of those observed by aircraft observations (2008–2014). When the NEI 2011 C2H6 emission totals are scaled by a factor of 1.4, the Goddard Earth Observing System Chem model largely reproduces a regional suite of observations, with the exception of the central U.S., where it continues to underpredict observed mixing ratios in the lower troposphere. We estimate monthly mean contributions of fossil fuel C2H6 emissions to ozone and peroxyacetyl nitrate surface mixing ratios over North America of ~1% and ~8%, respectively. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
See detailCarbon dioxide evasion from the Seine River: Drivers analysis and spatiotemporal reconstruction
Marescaux, A; Thieu, v; Borges, Alberto ULg et al

Conference (2017, February 26)

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailThermal comfort models for net zero energy buildings in hot climates
Belkhouane, Hamza ULg; Hensen, Jan; Attia, Shady ULg

in Second International Conference on Energy and Indoor Environment for Hot Climates (2017, February 26)

Several energy efficiency concepts and comfort models emerged in the last 15 years seeking high performance buildings and optimal occupant comfort conditions. The aim of high performance buildings is to ... [more ▼]

Several energy efficiency concepts and comfort models emerged in the last 15 years seeking high performance buildings and optimal occupant comfort conditions. The aim of high performance buildings is to reduce the carbon footprint and energy consumption of buildings while maintain a fit to purpose comfort. In this context, this work raises the question of fir to purpose comfort models that can from one side reduce the energy consumption of typical office buildings in hot climates (cooling dominated) while on the other side ensuring indoor thermal comfort. Indeed, studies that address energy efficiency are many, however it is in most cases applied to temperate or cold climates and barely explored for hot climates. The objective of this paper is to (1) combine several comfort models for a net zero energy building in hot climates, (2) select the comfort model that shows the optimal comfort quality of indoor environment and (3) compare the building's annual energy consumption for each used comfort model. To respond to our research problems, a methodology has been established, which goes through several phases. First identifying the different comfort models comfortable to use in hot climates (ISO 7730 / EN 15251 / adaptive ASHRAE / Givoni), secondly selecting a typical validated office building model as a reference building and finally selecting representative cities in the Mediterranean arid and hot climate (Algiers / Sicily / Cairo / Dubai). The study used building performance simulation to generate the different results on the energy consumption and the operative temperatures of the different models of comfort in each city. The paper ultimately identifies the fit to purpose comfort models for a medium size net zero energy office building in hot climates. The paper presents a comparison that can help building professional to identify the most appropriate comfort model that allows optimizing energy consumption, ensuring thermal comfort for robust perfromnce of net zero energy buildings in hot climates. [less ▲]

Detailed reference viewed: 97 (5 ULg)
See detailI Am Very Sorry Sir! Breaking Bad News to Customers
Delcourt, Cécile ULg; Gremler, Dwayne; Greer, Dominique

Scientific conference (2017, February 25)

Detailed reference viewed: 29 (2 ULg)
See detailGenscript meeting invited by GIGA viral vector platform
Golestan Hashemi, Farahnaz Sadat ULg

Learning material (2017)

Detailed reference viewed: 23 (2 ULg)
Peer Reviewed
See detailMethylglyoxal-induced carbonyl stress: perspectives of a new anti-GBM therapy
Nokin, Marie-Julie ULg

Conference (2017, February 24)

Detailed reference viewed: 20 (1 ULg)
See detailCompréhension et prise en charge de la schizophrénie : Présentation du modèle « 3Id »
Englebert, Jérôme ULg

Scientific conference (2017, February 24)

Detailed reference viewed: 26 (1 ULg)
Full Text
See detailLes éventrations parastomales: prévention et traitement
DETRY, Olivier ULg

Scientific conference (2017, February 24)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailInterplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis.
Leclercq, Sophie ULg; Derouaux, Adeline ULg; Olatunji, Samir ULg et al

in Scientific Reports (2017), 7

Bacteria utilize specialized multi-protein machineries to synthesize the essential peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG synthesis and separation of ... [more ▼]

Bacteria utilize specialized multi-protein machineries to synthesize the essential peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG synthesis and separation of daughter cells. In E. coli, the lipid II transporter candidate FtsW is thought to work in concert with the PG synthases penicillin-binding proteins PBP3 and PBP1b. Yet, the exact molecular mechanisms of their function in complexes are largely unknown. We show that FtsW interacts with PBP1b and lipid II and that PBP1b, FtsW and PBP3 co-purify suggesting that they form a trimeric complex. We also show that the large loop between transmembrane helices 7 and 8 of FtsW is important for the interaction with PBP3. Moreover, we found that FtsW, but not the other flippase candidate MurJ, impairs lipid II polymerization and peptide cross-linking activities of PBP1b, and that PBP3 relieves these inhibitory effects. All together the results suggest that FtsW interacts with lipid II preventing its polymerization by PBP1b unless PBP3 is also present, indicating that PBP3 facilitates lipid II release and/or its transfer to PBP1b after transport across the cytoplasmic membrane. This tight regulatory mechanism is consistent with the cell's need to ensure appropriate use of the limited pool of lipid II. [less ▲]

Detailed reference viewed: 13 (6 ULg)