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See detailLimited Impact of Imatinib in a Murine Model of Sclerodermatouc Chronic Graft-versus-Host Disease
Belle, Ludovic; Fransolet, Gilles ULg; Somja, Joan ULg et al

in PLoS ONE (2016)

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β ... [more ▼]

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β) play a significant role in the fibrosing process occurring in scl-cGVHD. This prompted us to assess the impact of the PDGF-r and c-Abl tyrosine kinase inhibitor imatinib on scl-cGVHD. Methods To assess the impact of imatinib on T cell subset proliferation in vivo, Balb/cJ recipient mice were lethally (7 Gy) irradiated and then injected with 10x106 bone marrow cells from B10.D2 mice on day 0. Fourteen days later, 70x106 carboxyfluorescein succinimidyl ester (CFSE)- labeled splenocytes from B10.D2 mice were infused and imatinib or sterile water was administered for 5 days. To induce severe scl-cGVHD, Balb/cJ mice were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donor mice after 7 Gy irradiation. Mice were then given sterile water or imatinib from day +7 after transplantation to the end of the experiment (day +52). Results Imatinib decreased the proliferation of total T cells (P = 0.02), CD8+ T cells (P = 0.01), and of regulatory T cells (Tregs) (P = 0.02) in the spleen. In the severe scl-cGVHD model, imatinib- treated mice had significantly lower levels of PDGF-r phosphorylation than control mice on day 29 after transplantation (P = 0.008). However, scl-cGVHD scores were similar between vehicle- and imatinib-treated mice during the whole experiment, while there was a suggestion for less weight loss in imatinib-treated mice that reached statistical significance at day +52 following transplantation (P = 0.02). [less ▲]

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See detailRenverser la machine: de la technique comme outil d’exploitation à la technique comme moyen de régénération environnementale: l’approche paysagère comme préalable à la réhabilitation des sites industriels désaffectés dans la Province de Liège.
Baldin, Elisa ULg

Poster (2016, December 12)

A partir de l’interaction entre pensée architecturale et dynamique de l’environnement, la recherche touche les problématiques de régénération des sites industriels désaffectés du bassin liégeois en ... [more ▼]

A partir de l’interaction entre pensée architecturale et dynamique de l’environnement, la recherche touche les problématiques de régénération des sites industriels désaffectés du bassin liégeois en mettant à l’épreuve le principe de « recyclage » architectural et paysager. Le site Espérance Longdoz, à Seraing, représente, en tant qu’objet de mon travail de fin d’études, un cas spécifique mais indicatif d’un phénomène territoriale, qui concerne la Vallée de la Meuse. Le projet d’aménagement urbain, où le re-dessin de l’espace se fonde sur une re-interprétation des traces existantes, ouvre à une réflexion sur la complémentarité des éléments artificiels et des éléments naturels dans le projet de régénération urbaine. L’approche paysagère intégrée est proposée comme outil pour activer des nouveaux cycles de vie, selon une dynamique écologique fondée sur la continuité à trouver entre ressource et déchet: une alternative à l’abandon et à la disparition des lieux qui ont construit l’histoire sociale et l’identité du territoire. Lectures et observations des mutations morphologiques, complétées par des analyses comparatives entre expériences locales et européennes similaires concernant des réalisations, projets en cours et acteurs engagés, fondent une réflexion critique centrée sur le renversement du sens de la machine: autrefois celle qui a exploité et bouleversé les équilibres de la terre et aujourd’hui à l’opposé, celle qui se développe et transforme les milieux à travers temporalités et actions naturelles. La thèse explore les technologies soft, de phyto-dépollution ou autre procédés de transformation naturelle, à réinsérer dans le processus de mutation de nos milieux de vie comme un système de structures d’assainissement environnemental et comme un ensemble de stratégies de reconstitution d’un paysage productif urbain/périurbain, capables de réactiver des moyens soutenables aptes à « renverser la machine » d’exploitation industrielle. [less ▲]

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See detailLes multiples transgressions de "Some Like It Hot" de Billy Wilder (1959)
Tomasovic, Dick ULg

Conference given outside the academic context (2016)

Présentation et analyse du film "Some Like It Hot" de Billy Wilder (1959).

Detailed reference viewed: 14 (0 ULg)
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See detailRenverser la machine: de la technique comme outil d’exploitation à la technique comme moyen de régénération environnementale: l’approche paysagère comme préalable à la réhabilitation des sites industriels désaffectés dans la Province de Liège.
Baldin, Elisa ULg

Scientific conference (2016, December 12)

A partir de l’interaction entre pensée architecturale et dynamique de l’environnement, la recherche touche les problématiques de régénération des sites industriels désaffectés du bassin liégeois en ... [more ▼]

A partir de l’interaction entre pensée architecturale et dynamique de l’environnement, la recherche touche les problématiques de régénération des sites industriels désaffectés du bassin liégeois en mettant à l’épreuve le principe de « recyclage » architectural et paysager. Le site Espérance Longdoz, à Seraing, représente, en tant qu’objet de mon travail de fin d’études, un cas spécifique mais indicatif d’un phénomène territoriale, qui concerne la Vallée de la Meuse. Le projet d’aménagement urbain, où le re-dessin de l’espace se fonde sur une re-interprétation des traces existantes, ouvre à une réflexion sur la complémentarité des éléments artificiels et des éléments naturels dans le projet de régénération urbaine. L’approche paysagère intégrée est proposée comme outil pour activer des nouveaux cycles de vie, selon une dynamique écologique fondée sur la continuité à trouver entre ressource et déchet: une alternative à l’abandon et à la disparition des lieux qui ont construit l’histoire sociale et l’identité du territoire. Lectures et observations des mutations morphologiques, complétées par des analyses comparatives entre expériences locales et européennes similaires concernant des réalisations, projets en cours et acteurs engagés, fondent une réflexion critique centrée sur le renversement du sens de la machine: autrefois celle qui a exploité et bouleversé les équilibres de la terre et aujourd’hui à l’opposé, celle qui se développe et transforme les milieux à travers temporalités et actions naturelles. La thèse explore les technologies soft, de phyto-dépollution ou autre procédés de transformation naturelle, à réinsérer dans le processus de mutation de nos milieux de vie comme un système de structures d’assainissement environnemental et comme un ensemble de stratégies de reconstitution d’un paysage productif urbain/périurbain, capables de réactiver des moyens soutenables aptes à « renverser la machine » d’exploitation industrielle. [less ▲]

Detailed reference viewed: 17 (2 ULg)
See detailSolar electrons observed in the magnetosphere
Shi, Quanqi; Wang, linghua; Zong, Qiugang et al

Poster (2016, December 12)

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See detailLa faisabilité et l'efficacité du traitement assisté par diacétylmorphine en Belgique
Demaret, Isabelle ULg

Doctoral thesis (2016)

Objective The aim of our research was to assess the feasibility and efficacy of a treatment assisted by diacetylmorphine in Liège. This treatment is offered to persons dependent on heroin who pursue ... [more ▼]

Objective The aim of our research was to assess the feasibility and efficacy of a treatment assisted by diacetylmorphine in Liège. This treatment is offered to persons dependent on heroin who pursue street heroin use despite existing treatments. Methods Data were collected in a pilot project of Treatment Assisted by Diacetylmorphine (TADAM), which took place in Liège from 2007 to 2013. The heart of this project is a randomised controlled trial comparing a diacetylmorphine treatment – limited to 12 months – with existing methadone treatments. A participant was responder if he/she showed improvement on the level of street heroin use, health or criminal involvement. Other researches (mainly based on interviews) were added in order to understand interactions between the trial and its actors: heroin users (included or not-included), neighbours of the DAM centre, the staff of the DAM centre and staff of other institutions who worked with our target group in Liège. Results With the help of the centres, partners of the trial, 74 participants (of the 200 planned) were included and randomised: 36 in the experimental group and 38 in the control group. These participants were dependent on heroin for 20 years on average and had already tried 9 treatments for their addiction(s). At the end of the trial, the number of responders in the experimental group was greater but not significantly than in the control group (p=0.35). However, participants in the experimental group showed greater improvement than in the control group, on the level of street heroin use (p=0.0011) and physical (p=0.043) or mental (p=0.035) health. During the follow-up study, three months after the end of the 12 months of treatment, street heroin use in the experimental group had significantly increased (p=0.0052) and the difference with the control group was no longer significant (p=0.55). Discussion Participants included in the trial were, as expected, persons severely dependent on street heroin, who could not find a solution to their addiction with the existing treatments. Participants in the experimental group decreased significantly their street heroin use. However, in our follow-up study, street heroin use increased significantly in the experimental group 3 months after the end of the diacetylmorphine treatment. In the foreign studies, diacetylmorphine treatment showed greater efficacy compared to methadone treatment for this target group and the improvement was sustained after the trial even when the treatment was stopped, but not when the end of treatment was forced against the will of the patient. Nevertheless, our research showed the feasibility of a diacetylmorphine treatment in Liège and its acceptance by the actors involved in the trial. Conclusion Diacetylmorphine treatment is feasible in Belgium. In foreign studies, it showed more efficacy than methadone treatment and benefits gained with this approach were maintained during years. But these benefits disappear when the end of treatment is forced, against the will of the patient. [less ▲]

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See detailUnreinforced clay masonry structures: advanced characterisation of the seismic behaviour including acoustic issues
Mordant, Christophe ULg

Doctoral thesis (2016)

Unreinforced masonry (URM) is traditionally used in North-Western Europe as load- bearing solution for low- to mid-rise buildings. These regions are characterised by a low- to-moderate seismicity. Hence ... [more ▼]

Unreinforced masonry (URM) is traditionally used in North-Western Europe as load- bearing solution for low- to mid-rise buildings. These regions are characterised by a low- to-moderate seismicity. Hence, the earthquake action has to be considered in the structural design. An adequate consideration of the seismic action requires to properly understand how the URM structures behave under this speci c dynamic action and investigations are still needed in that eld. The in uence of openings and walls perpendicular to the seismic action are two main issues. Moreover, the seismic response of these structures is a ected by technical solutions developed to face the demand in terms of building physics performances. Even though, these solutions are not yet integrated in current standards. This thesis aims at improving the understanding of the seismic behaviour of URM struc- tures using a particular type of masonry bonding, for constructional e ciency purposes. Hollow clay blocks are assembled by thin-bed layered glue-mortar joints and a tongue-and- groove system for the head joints. The consequences of speci c details such as an opening, a perpendicular wall or soundproo ng rubber layers are also studied. Four experimental campaigns are presented. Fourteen URM sub-structures including speci c details are tested in static-cyclic and dynamic conditions. Details of the set-up, instrumentation layout and testing procedures are given. Processing of the data is then performed and conclusions are drawn. Regarding the shake table tests, a general rocking be- haviour strongly dependent on the length of the wall and the presence of rubber, is observed. Recommendations for the consideration of soundproo ng devices and for the openings are proposed. The contribution to the strength of perpendicular walls is also highlighted. Based on the dynamic characterisation of the specimens, equivalent mechanical properties are calibrated thanks to the frequency equation, derived from the Timoshenko beam theory. Two sets of boundary conditions are de ned to t the testing con gurations. The relevance of this theory is assessed and the importance of each term of the equation is discussed. In order to extend the results to complete buildings, the tested specimens are modelled in a software implementing an equivalent frame at the macro-scale. A multi-linear material law is calibrated based on a single specimen chosen as reference, in order to reproduce the experimental force-displacement curve. This law is then used for all specimens built in the same masonry type, independently of their geometry. A good approximation is obtained, even if the consideration of perpendicular walls could be improved. The shear capacity of non-rectangular URM walls depends on the compressive length. Its exact expression is thus developed with due consideration of the perpendicular section. Non linearities are observed due to the presence of the perpendicular section and simpli - cations are made for hand calculations. Both the use of the exact and simpli ed expressions in the assessment of the shear resistance provide results similar to the experiments. Finally, the modelling of the rocking motion is investigated. The walls without sound- proo ng devices are modelled following di erent existing models and their predictions are compared with experimental measurements, showing that masonry cannot be assumed as rigid. A main issue is the handling of the transition with impacts. A new model including two rigid blocks and exible and viscous layers is developed to reproduce the rocking behaviour of walls including rubber layers. In presence of rubber, the URM wall can be considered as rigid and model predictions satisfactorily corroborate the experimental measurements. [less ▲]

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See detailQuand le paysage parle. Documentaire, histoire et témoignage.
Hamers, Jérémy ULg; Hagelstein, Maud ULg

Scientific conference (2016, December 12)

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See detailNanoparticles-nanosubstrates hybrids through one pot synthesis by plasma treatment: towards optimization of Pt/carbon catalysts for PEM fuel cells
Busby, Yan; Gulas, Michal; Laurent-Brocq, Mathilde et al

Conference (2016, December 12)

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See detailLa faisabilité et l'efficacité du traitement assisté par diacétylmorphine en Belgique
Demaret, Isabelle ULg

Scientific conference (2016, December 12)

Objective The aim of our research was to assess the feasibility and efficacy of a treatment assisted by diacetylmorphine in Liège. This treatment is offered to persons dependent on heroin who pursue ... [more ▼]

Objective The aim of our research was to assess the feasibility and efficacy of a treatment assisted by diacetylmorphine in Liège. This treatment is offered to persons dependent on heroin who pursue street heroin use despite existing treatments. Methods Data were collected in a pilot project of Treatment Assisted by Diacetylmorphine (TADAM), which took place in Liège from 2007 to 2013. The heart of this project is a randomised controlled trial comparing a diacetylmorphine treatment – limited to 12 months – with existing methadone treatments. A participant was responder if he/she showed improvement on the level of street heroin use, health or criminal involvement. Other researches (mainly based on interviews) were added in order to understand interactions between the trial and its actors: heroin users (included or not-included), neighbours of the DAM centre, the staff of the DAM centre and staff of other institutions who worked with our target group in Liège. Results With the help of the centres, partners of the trial, 74 participants (of the 200 planned) were included and randomised: 36 in the experimental group and 38 in the control group. These participants were dependent on heroin for 20 years on average and had already tried 9 treatments for their addiction(s). At the end of the trial, the number of responders in the experimental group was greater but not significantly than in the control group (p=0.35). However, participants in the experimental group showed greater improvement than in the control group, on the level of street heroin use (p=0.0011) and physical (p=0.043) or mental (p=0.035) health. During the follow-up study, three months after the end of the 12 months of treatment, street heroin use in the experimental group had significantly increased (p=0.0052) and the difference with the control group was no longer significant (p=0.55). Discussion Participants included in the trial were, as expected, persons severely dependent on street heroin, who could not find a solution to their addiction with the existing treatments. Participants in the experimental group decreased significantly their street heroin use. However, in our follow-up study, street heroin use increased significantly in the experimental group 3 months after the end of the diacetylmorphine treatment. In the foreign studies, diacetylmorphine treatment showed greater efficacy compared to methadone treatment for this target group and the improvement was sustained after the trial even when the treatment was stopped, but not when the end of treatment was forced against the will of the patient. Nevertheless, our research showed the feasibility of a diacetylmorphine treatment in Liège and its acceptance by the actors involved in the trial. Conclusion Diacetylmorphine treatment is feasible in Belgium. In foreign studies, it showed more efficacy than methadone treatment and benefits gained with this approach were maintained during years. But these benefits disappear when the end of treatment is forced, against the will of the patient. [less ▲]

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See detailLe futur du travail à l'ère digitale
Delvenne, Pierre ULg

Conference given outside the academic context (2016)

Cette présentation aborde de manière critique les changements qui s'opèrent dans le monde du travail sous l'impulsion des technologies digitales (robotisation, automatisation, objets connectés, etc). Dans ... [more ▼]

Cette présentation aborde de manière critique les changements qui s'opèrent dans le monde du travail sous l'impulsion des technologies digitales (robotisation, automatisation, objets connectés, etc). Dans une perspective interdisciplinaire, à l'aide de nombreux exemples, elle aborde les interactions entre la technologie, l'économie, la société et le politique et examine les conditions d'émergences et les conséquences des changements en cours sur le monde du travail. Elle invite à prendre urgemment la pleine mesure de la rupture qui s'opère avec la digitalisation et formule des recommandations concrètes. [less ▲]

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See detailÉcrire sur ses apprentissages dans un journal
Scheepers, Caroline ULg

Conference given outside the academic context (2016)

La formation est destinée aux enseignants du cycle 3 qui travaillent dans les établissements classés ZEP de Sarcelles. Elle vise à leur expliciter les fondements et modalités du journal des apprentissages ... [more ▼]

La formation est destinée aux enseignants du cycle 3 qui travaillent dans les établissements classés ZEP de Sarcelles. Elle vise à leur expliciter les fondements et modalités du journal des apprentissages que tiennent des élèves de primaire ou de secondaire. [less ▲]

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See detailSébastien Labbé Research Code: slabbe 0.3.b2
Labbé, Sébastien ULg

Software (2016)

Detailed reference viewed: 11 (0 ULg)
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See detailExploitation of coastal fish communities by harbour porpoises Phocoena phocoena during nursing periods in German Baltic waters.
Pinzone, Marianna ULg; Michel, Loïc ULg; Gallus, Anja et al

Conference (2016, December 11)

Baltic sub-populations of harbour porpoises Phocoena phocoena meet in in Southwestern waters in Spring when females reach the coastal areas for calving and nursing. In Autumn they separate again for ... [more ▼]

Baltic sub-populations of harbour porpoises Phocoena phocoena meet in in Southwestern waters in Spring when females reach the coastal areas for calving and nursing. In Autumn they separate again for reproduction : the Belt sea populations westwards in the Kattegat/Skarregat region, the Baltic proper population northwards in the central basin. The increased number of juvenile and newborn strandings along the German Baltic coasts give evidence for a possible existence of local calving grounds in this area. Calving and nursing habitats are the most important areas for management purposes. This project aimed to describe inhabitancy and diet of females and calves along the German Baltic coast, in order to achieve effective conservation measures. Nitrogen, carbon and, for the first time, sulphur stable isotopes (δ13C, δ15N and δ34S) were analysed in coastal species of fish and invertebrates in spring, autumn and winter 2015/2016 and in four different areas, to assess for seasonal and geographical variation of porpoises habitat use. The structure of ecological niches was inferred within and between communities using the SIBER model, and was compared to results from stomach content analysis. N, C and S values of fish and invertebrates strongly varied, seasonally and geographically, as a consequence of environmental factors characteristic of each sampling area. Additionally, each species presented large isotopic variability, suggesting possible intraspecific dietary specialisations. Females δ13C and δ34S signatures integrated both open-waters and coastal feeding, while juveniles presented a more coastal distribution. The absence of difference in δ15N values between age classes confirmed persistence of milk assimilation from the mothers. Niches structures and overlaps and stomach content analysis suggested gobies (Potamoschistus spp and Neogobius spp in particular), crabs and small coastal fish (ex. three-spined stickleback) as the main preys of juveniles. The integration of all three stable isotopes together permitted to well delineate even the highly dynamic food web of the Baltic German waters, confirming the use of sulphur isotopes in marine ecological studies. [less ▲]

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See detailInitiatives populaires de solidarité internationale, des « bonnes intentions » au « professionnalisme » ? Sociologie d’un groupe professionnel à l’aune du sentiment de légitimité, dans une perspective comparative Belgique / France
Godin, Julie ULg

Doctoral thesis (2016)

Alongside established, high-profile non-governmental organisations (NGOs), many individuals decide that they need to “do something” to improve the lives of the people they have met (while travelling ... [more ▼]

Alongside established, high-profile non-governmental organisations (NGOs), many individuals decide that they need to “do something” to improve the lives of the people they have met (while travelling, living in another country or adopting a child, etc.). These people join forces with a small group of friends to set up their own development organisations (referred to hereafter as “popular development initiatives”, or PDIs). At present, one of the major concerns in international development cooperation is to make development workers more professional in the interest of better aid effectiveness. This thesis therefore looks at the discourses and practices of these “ordinary” citizens, in order to highlight their role and to identify key issues for this sector. More specifically, we study the dialectic process by which NGO staff and PDI volunteers build and define their professional and amateur legitimacy as development actors, through the prism of the interactionist perspective of the sociology of professional groups. We also draw on the sociology of public action to consider how public authorities, through their policy tools, influence the responsibility and legitimacy of these actors, the interactions between them, and their mutual recognition. The need for professionalism also stems from demands by local partners in the developing world, so we have taken an interest in their perceptions in the case of Senegal. [less ▲]

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See detailEDX prognosis of focal neuropathies
WANG, François-Charles ULg

Scientific conference (2016, December 09)

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See detailConclusions
Kéfer, Fabienne ULg

Conference (2016, December 09)

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See detailLes contrats relatifs à la formation préalable à l'embauche
Linguelet, Renaud ULg; Kéfer, Fabienne ULg

in Mormont, Hugo (Ed.) Droit du travail tous azimuts (2016)

À côté du contrat de travail, le droit du travail s'intéresse à d'autres relations contractuelles caractérisées par la subordination, que l'on nomme apprentissage et stage. Après avoir mis en avant la ... [more ▼]

À côté du contrat de travail, le droit du travail s'intéresse à d'autres relations contractuelles caractérisées par la subordination, que l'on nomme apprentissage et stage. Après avoir mis en avant la distinction entre le contrat de travail et les contrats relatifs à la formation préalable à l'embauche, la contribution propose un exposé synthétique des principaux types d'apprentissage et de stage. Elle se clôture par un relevé jurisprudentiel des éléments pertinents qui permettent de s'assurer que l'objet du contrat est la formation à un métier et non la réalisation d'un travail en contrepartie d'une rémunération. [less ▲]

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