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See detailInterplay of structural and electronic stabilizing factors in neutral and cationic phosphine protected Au13 clusters
Fresch, Barbara ULg; Hanozin, Emeline ULg; Dufour, Fabien ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (2012), 66(12),

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See detailLa performance de l'entreprise sociale : définitions et limites d'une évaluation monétaire
Mertens de Wilmars, Sybille ULg; Marée, Michel ULg

in Revue Internationale P.M.E. (2012), 25(3-4), 91-122

In a social enterprise, the notion of "performance" must be understood in a broader sense than the sole financial profitability. Because enterprises of this type pursue a social mission, whose completion ... [more ▼]

In a social enterprise, the notion of "performance" must be understood in a broader sense than the sole financial profitability. Because enterprises of this type pursue a social mission, whose completion generates collective impacts, one has to go beyond what is made possible by the sole market-based indicators. This requires to revise not only the very notion of production, but also the way in which the value of what is produced by the enterprise is measured. This is the task that the authors of the present article tackle, through building a definition of performance understood as "enlarged production" – a notion which they nevertheless define with accuracy. Whenever the notion of production is enlarged so as to take into account the impacts of the latter, the question of whether this approach is also operational unavoidably arises. In particular, one must ask oneself whether the impacts that one wants to include in an enlarged conception of production are measurable. By nature, these impacts are not taken into account by the market and measuring them sends back to the classical question of the evaluation of non-market goods. The authors draw up an inventory of the various techniques of monetary evaluation of the value of non-market goods and indicate whether these techniques are likely to lead to values that are relevant to evaluate the performance of a social enterprise. They illustrate their analysis by applying this grid of analysis to the methodology of social return on investment (SROI). Because of the theoretical limits of monetary evaluation, the authors conclude that works on performance evaluation based on multi-criteria analyses must be further pursued. [less ▲]

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See detailAcute intramural haematoma of the ascending aorta.
Govaerts, L.; WITHOFS, Nadia ULg; Durieux, R. et al

in European Journal of Nuclear Medicine and Molecular Imaging (2012), 39(8), 1368-9

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See detailEnergetic Aspects of Non-Radial Solar-Like Oscillations in Red Giants
Dupret, Marc-Antoine ULg; Belkacem, Kevin; Montalbán, Josefina et al

in Astrophysics and Space Science Proceedings (2012)

The non-radial oscillations discovered by CoRoT (see e.g. de Ridder et al. (2009)) and by Kepler(see e.g. Bedding et al. (2010)) in thousands of red giants constitute a wonderful mine of information to ... [more ▼]

The non-radial oscillations discovered by CoRoT (see e.g. de Ridder et al. (2009)) and by Kepler(see e.g. Bedding et al. (2010)) in thousands of red giants constitute a wonderful mine of information to determine their global characteristics and probe their internal structure. A. Miglio and J. Montalbán have presented in detail in this conference the seismic structure of red giants, the information hold by their oscillation frequencies, and how it can be used. An adiabatic analysis of the oscillations was sufficient at this level as the frequencies are mainly determined by the deep layers were the oscillatons are quasi-adiabatic. We consider here energetic aspects of non-radial oscillations in red-giants. Non-adiabatic models of solar-like oscillations are required to determine the theoretical amplitude and lifetimes of the modes. These parameters allow us to determine how power spectra are expected to look like, depending on the structure of the red giant. Comparison with the observed measures gives thus additional constraints on the models. [less ▲]

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See detailUsing the N/C ratio to correct bulk radiocarbon ages from lake sediments: Insights from Chilean Patagonia
Bertrand, Sébastien; Arraneda, A.; Vargas, P. et al

in Quaternary Geochronology (2012), 12

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See detailA structural study of the lithiophilite-sicklerite series.
Hatert, Frédéric ULg; Ottolini, Luisa; Wouters, Johan et al

in Canadian Mineralogist (2012), 50

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See detailMinéralogie de la carrière de Beez, Province de Namur, Belgique.
Blondieau, Michel; Hatert, Frédéric ULg; Defoy, Michel

in Règne minéral (Le) (2012), 104

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 12. New minerals and nomenclature modifications approved in 2012.
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2012), 76(1), 151-155

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See detailIMA Commission on New Minerals, Nomenclature and Classification (CNMNC), Newsletter 14. New minerals and nomenclature modifications approved in 2012.
Williams, Pete; Hatert, Frédéric ULg; Pasero, Marco et al

in Mineralogical Magazine (2012), 76(5), 1281-1288

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See detailClinical utility gene card for: Biotinidase deficiency
Küry, S.; RAMAEKERS, Vincent ULg; Bézieau, S. et al

in European Journal of Human Genetics (2012), 20(5), 592

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See detailELISA : ECHELLE LIÉGEOISE DE L’INDICE DE SÉVÉRITÉ À L’ADMISSION
JOBE, Jérôme ULg; Ghuysen, Alexandre ULg; D'Orio, Vincenzo ULg

in Revue Médicale de Liège (2012), 67(12), 632-637

Les services d’urgence sont régulièrement confrontés au problème d’encombrement à l’admission par une demande qui dépasse l’offre de soins. Il est essentiel de réguler le flux d’entrée par la mise en ... [more ▼]

Les services d’urgence sont régulièrement confrontés au problème d’encombrement à l’admission par une demande qui dépasse l’offre de soins. Il est essentiel de réguler le flux d’entrée par la mise en place d’un dispositif de tri. Ce mécanisme s’affine depuis une quinzaine d’années. Nous proposons un algorithme de tri (ELISA ou Echelle Liégeoise de l’Indice de Sévérité à l’Admission) qui vise à définir l’état d’urgence selon 5 niveaux depuis la catégorie U1 (urgence absolue) à U5 (urgence relative). Ces niveaux sont associés à un délai de contact médical (immédiat à 120 minutes) et à un trajet de soin correspondant (salle de déchoquage, secteur B ou brancard, secteur A ou ambulatoire, salle d’attente) réunissant ainsi des impératifs de temps et de lieu de prise en charge optimaux. Notre algorithme de tri montre une excellente fiabilité par la comparaison du niveau initial de la catégorisation au devenir du patient (soins intensifs, hospitalisation, et sortie du service). [less ▲]

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See detailL'impact de la motivation et des émotions sur les aspirations professionnelles des jeunes de 15 ans
Dupont, Virginie ULg; Monseur, Christian ULg; Lafontaine, Dominique ULg et al

in Revue Française de Pédagogie (2012), (181), 55-70

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See detailSleep, memory and the hippocampus
Foret, Ariane; Mascetti, Laura ULg; Kussé, Caroline ULg et al

in Clinical Neurobiology of the Hippocampus (2012)

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See detailNext-Generation Sequencing for Rodent Barcoding: Species Identification from Fresh, Degraded and Environmental Samples
Galan, Maxime; Pagès, Marie ULg; Cosson, Jean-François

in PLoS ONE (2012), 7(11), 48374

Rodentia are one of the most diverse orders among mammals, with more than 2,000 species currently described. Species assignation based on morphological data alone can present enormous challenges. In this ... [more ▼]

Rodentia are one of the most diverse orders among mammals, with more than 2,000 species currently described. Species assignation based on morphological data alone can present enormous challenges. In this study, we compared the applicability of 100 bp mini-barcodes from cytochrome b and cytochrome c oxidase 1 genes to enable rodent species identification. Based on GenBank sequence datasets of 115 rodent species, a 136 bp fragment of cytochrome b combined with universal rodent primers was selected as the most discriminatory mini-barcode. The efficacy of this new molecular tool was assessed on 946 samples including rodent tissues, feces, museum samples and feces/pellets from predators known to ingest rodents. Utilizing next generation sequencing technologies able to sequence multiple DNAs, 1,140 amplicons were tagged, multiplexed and sequenced together in one single 454 GS-FLX run. Our method was initially validated on a reference sample set including 265 clearly identified rodent tissues, corresponding to 103 different species. Following validation, 85.6% of 555 rodent samples from Europe, Asia and Africa whose species identity was unknown were able to be identified using the BLASTN program and GenBank reference sequences. In addition, our method proved effective even on degraded rodent DNA samples: 91.8% and 75.9% of samples from feces and museum specimens respectively were correctly identified. Finally, we succeeded in determining the diet of 66.7% of the investigated carnivores from their feces and 81.8% of owls from their pellets. Non-rodent species were also identified suggesting that our method is sensitive enough to investigate complete predator diets. This study demonstrates how this molecular identification method combined with high throughput sequencing can open new realms of possibilities in achieving fast, accurate and inexpensive species identification. [less ▲]

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See detailEinzigartigkeiten: Pluralrestriktionen im Wörterbuch
Münzberg, Franziska ULg

in Bär, Jochen; Müller, Marcus (Eds.) Geschichte der Sprache – Sprache der Geschichte. Probleme und Perspektiven der historischen Sprachwissenschaft des Deutschen (2012)

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See detailADAMTS-12 metalloprotease is necessary for normal inflammatory response.
Moncada-Pazos, Angela; Obaya, Alvaro J.; Llamazares, Maria et al

in Journal of Biological Chemistry (2012), 287(47), 39554-63

ADAMTSs (a disintegrin and metalloprotease with thrombospondin domains) are a family of enzymes with both proteolytic and protein interaction functions, which have been implicated in distinct pathologies ... [more ▼]

ADAMTSs (a disintegrin and metalloprotease with thrombospondin domains) are a family of enzymes with both proteolytic and protein interaction functions, which have been implicated in distinct pathologies. In this work, we have investigated the putative role of ADAMTS-12 in inflammation by using a mouse model deficient in this metalloprotease. Control and mutant mice were subjected to different experimental conditions to induce colitis, endotoxic sepsis, and pancreatitis. We have observed that Adamts12-deficient mice exhibit more severe inflammation and a delayed recovery from these challenges compared with their wild-type littermates. These changes are accompanied by an increase in inflammatory markers including several cytokines, as assessed by microarray expression analysis and proteomic-based approaches. Interestingly, the clinical symptoms observed in Adamts12-deficient mice are also concomitant with an elevation in the number of neutrophils in affected tissues. Finally, isolation and in vitro culture of human neutrophils demonstrate that the presence of ADAMTS-12 induces neutrophil apoptosis. On the basis of these results, we propose that ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis. [less ▲]

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See detailDeleterious mutations in LRBA are associated with a syndrome of immune deficiency and autoimmunity.
Lopez-Herrera, Gabriela; Tampella, Giacomo; Pan-Hammarstrom, Qiang et al

in American Journal of Human Genetics (2012), 90(6), 986-1001

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both autosomal-dominant and autosomal-recessive ... [more ▼]

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both autosomal-dominant and autosomal-recessive inheritance have been described. We performed genetic linkage analysis in consanguineous families affected by hypogammaglobulinemia. Four consanguineous families with childhood-onset humoral immune deficiency and features of autoimmunity shared genotype evidence for a linkage interval on chromosome 4q. Sequencing of positional candidate genes revealed that in each family, affected individuals had a distinct homozygous mutation in LRBA (lipopolysaccharide responsive beige-like anchor protein). All LRBA mutations segregated with the disease because homozygous individuals showed hypogammaglobulinemia and autoimmunity, whereas heterozygous individuals were healthy. These mutations were absent in healthy controls. Individuals with homozygous LRBA mutations had no LRBA, had disturbed B cell development, defective in vitro B cell activation, plasmablast formation, and immunoglobulin secretion, and had low proliferative responses. We conclude that mutations in LRBA cause an immune deficiency characterized by defects in B cell activation and autophagy and by susceptibility to apoptosis, all of which are associated with a clinical phenotype of hypogammaglobulinemia and autoimmunity. [less ▲]

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See detailL'application du droit européen de la concurrence par l'arbitre
Caprasse, Olivier ULg

in Mayer, Pierre (Ed.) Arbitrage et droit de l'Union Européenne (2012)

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See detailAn expanding Universe without dark matter and dark energy
Magain, Pierre ULg

E-print/Working paper (2012)

Assuming that observers located inside the Universe measure a time flow which is different from the time appearing in the Friedmann-Lemaıtre equation, and determining this time flow such that the Universe ... [more ▼]

Assuming that observers located inside the Universe measure a time flow which is different from the time appearing in the Friedmann-Lemaıtre equation, and determining this time flow such that the Universe always appears flat to these observers, we derive a simple cosmological model which allows to explain the velocity dispersions of galaxies in galaxy clusters without introducing dark matter. It also solves the horizon problem without recourse to inflation. Moreover, it explains the present acceleration of the expansion without any resort to dark energy and provides a good fit to the observations of distant supernovæ. Depending on the present value of the matter-energy density, we calculate an age of the Universe between 15.4 and 16.5 billion years, ignificantly larger than the 13.7 billion years of the standard CDM model. Our model has a slower expansion rate in the early epochs, thus leaving more time for the formation of structures such as stars and galaxies. [less ▲]

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