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See detailL’éjaculation précoce : une perspective socio-historique
Kempeneers, Philippe ULg; ANDRIANNE, Robert ULg

in Sexualités Humaines : Revue de Sexologie des Professionnels de Santé (2016), 30

Le fait de considérer une éjaculation rapide comme un problème découle notamment des normes sexuelles qui prévalent dans un contexte socio-historique donné. À la fin du XXème siècle, l’éjaculation précoce ... [more ▼]

Le fait de considérer une éjaculation rapide comme un problème découle notamment des normes sexuelles qui prévalent dans un contexte socio-historique donné. À la fin du XXème siècle, l’éjaculation précoce (EP) est devenue, dans les pays occidentaux, un motif extrêmement répandu de consultation en sexopathologie masculine. Cette évolution n’est vraisemblablement pas sans rapport à d’autres phénomènes sociétaux. Citons une survalorisation relative du plaisir obtenu par induction coïtale, le développement des techniques contraceptives qui offrent aux gens les moyens sécurisés d’une politique érotique essentiellement pénétrative, et des aspirations à des durées de pénétration qui tendent à excéder les normes biologiques. C’est à partir de la seconde moitié du XXème siècle que s’est développée la clinique de l’EP. D’abord principalement psychosexologique, l’approche est devenue plutôt physiologique et médicamenteuse à partir des années 1990. Un troisième vague tend aujourd’hui à percevoir l’éjaculation rapide moins comme un trouble que comme une donnée constitutionnelle modulable via le développement d’habiletés comportementales et/ou par voie chimique, et à envisager les traitements dans le cadre global d’une finalité hédonique influencée tout à la fois par des facteurs biologiques, psychologiques et sociaux. [less ▲]

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See detailL'Instrumentalisation de figures historiques: comparaison des utilisations de Jeanne d'Arc par le FN et de Saint George par l'UKIP
Nossent, Jérôme ULg

in Jamin, Jérôme (Ed.) L'extrême droite en Europe (2016)

Étude comparée de la façon dont les deux partis politiques mobilisent chacun une figure historique spécifique.

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See detailEncore du nouveau à propos du Reliquaire de Charles le Téméraire
Dumont, Jonathan ULg

in Trésor de Liège : Bulletin Trimestriel (2016), 47(juin 2016), 3-7

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See detailCareer development for international researchers
Halleux, Isabelle ULg

Diverse speeche and writing (2016)

This talk as invited speaker aims to express how and why the stakeholders opinions converge on the competences required from researchers and the needs for their career assessment. Inspiring tools and very ... [more ▼]

This talk as invited speaker aims to express how and why the stakeholders opinions converge on the competences required from researchers and the needs for their career assessment. Inspiring tools and very good practices exist that be shared to help employers as well as the researchers themselves. [less ▲]

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See detailDental ceramics: classification and indications
Mainjot, Amélie ULg

in Esthetics in Dentistry (2016)

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See detailMyoclonin-1 modulates the post-translational modification of microtubules
Medard, Laurie ULg; Coumans, Bernard ULg; Lakaye, Bernard ULg et al

Poster (2016, June)

Juvenile myoclonic epilepsy is one of the most common forms of generalized genetic epilepsy. Genetic studies have shown that heterozygous mutations in Myoclonin1 are responsible for 3-9% of clinical cases ... [more ▼]

Juvenile myoclonic epilepsy is one of the most common forms of generalized genetic epilepsy. Genetic studies have shown that heterozygous mutations in Myoclonin1 are responsible for 3-9% of clinical cases worldwide. This protein contains three DM10 domains of unknown function and an EF-hand domain. We have previously demonstrated that Myoclonin1 is a microtubule-associated protein involved in cell division and radial migration during neocortex development. In cells, this protein co-localized with specific structures rich in microtubules (MTs) such as the centrosome, the poles of the mitotic spindle or the motile cilia but not with cytoplasmic MTs. This suggests post-translational modifications (PTM) of MTs may be important for the interaction between Myoclonin1 and MTs. We have co-express the different enzymes catalyzing PTM of MTs with Myoclonin1 in U2OS cell line. With one of these enzymes, we observed a strong increase in PTM in the presence of Myoclonin-1. This suggests that Myoclonin1 may interact with and modulate the activity of this enzyme. By using luciferase complementation assay and pull down experiments, we could demonstrate that it is indeed the case. Interestingly, the effect is observed even when a DM10 domain alone is co-expressed with the enzyme, suggesting for the first time a role for this domain. In conclusion our data suggest myoclonin-1 modulates specific PTM of MTs. This is of prime importance for microtubule dynamic and notably for neuroblast precursor migration during neocortex development. This could be the mechanism that explains why pathological forms of myoclonin-1 affect brain development. [less ▲]

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See detailGuidance Document on the Estimation of LOD and LOQ for Measurements in the Field of Contaminants in Food and Feed
Wenzl, Thomas; Haedrich, Johannes; Schaechtele, Alexander et al

Report (2016)

The European Union Reference Laboratory (EURL) for Polycyclic Aromatic Hydrocarbons (EURL PAH), the EURL for Heavy Metals in Feed and Food (EURL HM), the EURL for Mycotoxins (EURL Mycotoxins), and EURL ... [more ▼]

The European Union Reference Laboratory (EURL) for Polycyclic Aromatic Hydrocarbons (EURL PAH), the EURL for Heavy Metals in Feed and Food (EURL HM), the EURL for Mycotoxins (EURL Mycotoxins), and EURL for Dioxins and PCBs in Feed and Food aim to provide with this document guidance to official food control in the EU on the estimation of the limit of quantification of analytical methods for the determination of individual substances in the field of contaminants in feed and food. The document focusses on estimation of the limit of detection (LOD) and/or limit of quantification (LOQ) of polycyclic aromatic hydrocarbons (PAHs), heavy metals (HM), mycotoxins, and polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs). The concept presented here consists of two major routes: The first route responds to the requirements for determination of PAHs, HMs and Mycotoxins. The second route corresponds to PCDD/F and PCB analysis, where results are calculated as sumparameters and expressed in toxic equivalents (TEQs), converting thereby congener concentrations together with estimated LOQs using toxic equivalency factor (TEFs) into TEQs. Due to the nature of this more complex procedure, emphasis is put in the area of PCDD/F and PCB analysis on the LOQs, while LODs are of minor consequence. Terminology in this guidance document was adapted to the chemical analysis of contaminants in feed and food; hence, some of the general terms defined and used in international standards were replaced by more specific terms applicable to analytical chemistry. The presented statistical-mathematical approach is based on elements taken mainly from DIN 32645:2008-11 (DIN 2008) and ISO 11843-2:2000 (ISO 2000). This document covers only quantitative methods of analysis. The authors believe that LOD and LOQ values derived from the application of the presented experimental methodologies converge to a certain degree. Estimation of LOD/LOQ values based on blank measurements, and from calibration data is described. Signal-to-noise ratios are applied in the area of PCDD/Fs and PCBs. Mathematical terms and statistical background are presented as well. This guide document shall be applied systematically if measurement results are used for monitoring purposes and exposure modelling. However, authors are aware that precise knowledge of LOD/LOQ may not be required when assessing compliance with maximum levels exceeding LOD/LOQ. This guidance document shall be applied if maximum levels and analysis results are close to the expected LOQ. The authors acknowledge that the presented approach has its limitations and may not be generally applicable to all cases. [less ▲]

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See detail“The Sweet Smell of Chemistry” - Characterization of volatile mixtures from Life Sciences
Stefanuto, Pierre-Hugues ULg

Doctoral thesis (2016)

From a Separation Science standpoint, Life Sciences represent a broad source of complex compound mixtures that require powerful analytical strategies to be considered when characterization is aimed. The ... [more ▼]

From a Separation Science standpoint, Life Sciences represent a broad source of complex compound mixtures that require powerful analytical strategies to be considered when characterization is aimed. The depiction of the complex volatile organic compound (VOC) component of these mixtures is an important part of such characterization. The aim of this doctoral work was to develop a versatile analytical approach to resolve such VOC samples. For the characterization of complex VOC mixtures, comprehensive two-dimensional gas chromatography (GC×GC) is the method of choice. The combination of two GC separation columns offers higher peak capacity than single dimension GC (1D GC). Moreover, the hyphenation of GC×GC to a mass spectrometer provides an extra dimension of identification, especially when high-resolution (HR) time-of-flight mass spectrometers (TOFMS) is used. However, the optimization of the GC×GC conditions is not straightforward. Currently, there are no defined strategies to obtain the best capabilities these instruments, not only in terms of the optimization of the separation itself, but also mainly in terms of data processing efficiency. The first section of this work was devoted to the evaluation of theoretical aspects and the definition of a specific optimization strategy for GC×GC separation. The first part dealt with the heavily debated concept of ‘orthogonality’ was specifically investigated by means of a metric calculation, the Orthogonality Index (OI), linked to a new nomenclature describing the separation space usage. The second part was focused on the development of an optimization strategy for the sampling and the chromatographic separation of VOCs, as well as the processing of large sets of GC×GC data. This was conducted on complex beer aroma headspace replicates for sampling method selection, peak dispersion optimization, and robust multivariate statistical treatment. The third part of this theoretical investigation relied on the implementation of fast-GC conditions for GC×GC separation. The idea was to evaluate the effect of combining short columns, fast modulation, high temperature ramping, and high flow on GC×GC efficiency for explosive headspace analyses. In the second section, the focus was directed to challenging applications in the area of thanatochemistry, i.e. the chemistry of death, especially considering the volatile fraction of cadaveric decomposition, a complex chemical process releasing numerous VOCs. In this context, soil surrounding decomposing remains, headspace of cadavers, and more “specific” matrices (i.e. synthetic solutions and internal gas from decomposition) were analyzed by GC×GC TOFMS. Major attention was dedicated to the development of an analytical and data mining procedures for these complex VOC samples with emphasis on the study of the impact of different parameters on the cadaveric decomposition process. [less ▲]

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See detailNovel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signaling pathway.
Garcia-Caballero, Melissa; BLACHER, Silvia ULg; Paupert, J. et al

in British Journal of Pharmacology (2016), 173(12), 1966-87

BACKGROUND AND PURPOSE: Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphedema and other ... [more ▼]

BACKGROUND AND PURPOSE: Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphedema and other inflammatory disorders. The development of new drugs blocking lymphangiogenesis has become a promising therapeutic strategy. In this study, we aim at investigating the ability of toluquinol, a 2-methyl-hydroquinone isolated from the culture broth of the marine fungus Penicillium sp. HL-85-ALS5-R004, to inhibit lymphangiogenesis in vitro, ex vivo and in vivo. EXPERIMENTAL APPROACH: We used human lymphatic endothelial cells (LEC) to analyze the effect of toluquinol in 2D and 3D in vitro cultures, and in the ex vivo mouse lymphatic ring assay. For in vivo approaches, the transgenic Fli1:eGFPy1 zebrafish, the mouse ear sponges and cornea models were used. Western-blotting and apoptosis analyses were carried out to search for drug targets. KEY RESULTS: Toluquinol inhibited LEC proliferation, migration, tubulogenesis and sprouting of new lymphatic vessels. Furthermore, toluquinol induced LEC apoptosis after 14 h of treatment in vitro, blocked the thoracic duct development in zebrafish, and reduced the VEGF-C-induced lymphatic vessel formation and corneal neovascularization in mice. Mechanistically, we are providing evidence that this drug abrogates the VEGF-C-induced VEGFR-3 phosphorylation in a dose-dependent manner, and represses Akt and ERK1/2 phosphorylations. CONCLUSIONS AND IMPLICATIONS: Based on these findings, we propose toluquinol as a new candidate with pharmacological potential for the treatment of lymphangiogenesis-related pathologies. Notably, its ability to suppress corneal neovascularization paves the way for applications in vascular ocular pathologies. This article is protected by copyright. All rights reserved. [less ▲]

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See detailCompte rendu de Voltaire, Œuvres complètes, vol. 51A : Recueil des facéties parisiennes, éd. dirigée par Nicholas Cronk
Daubercies, Laurence ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2016)

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See detailCharacterisation of Phosphate Accumulating Organisms and Techniques for Polyphosphate Detection: A Review
Tarayre, Cédric ULg; Nguyen, Huu-Thanh; Brognaux, Alison ULg et al

in Sensors (2016), 16(797), 1-14

Phosphate minerals have long been used for the production of phosphorus-based chemicals used in many economic sectors. However, these resources are not renewable and the natural phosphate stocks are ... [more ▼]

Phosphate minerals have long been used for the production of phosphorus-based chemicals used in many economic sectors. However, these resources are not renewable and the natural phosphate stocks are decreasing. In this context, the research of new phosphate sources has become necessary. Many types of wastes contain non-negligible phosphate concentrations, such as wastewater. In wastewater treatment plants, phosphorus is eliminated by physicochemical and/or biological techniques. In this latter case, a specific microbiota, phosphate accumulating organisms (PAOs), accumulates phosphate as polyphosphate. This molecule can be considered as an alternative phosphate source, and is directly extracted from wastewater generated by human activities. This review focuses on the techniques which can be applied to enrich and try to isolate these PAOs, and to detect the presence of polyphosphate in microbial cells. [less ▲]

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See detailL’obligation d’aménagement raisonnable pour motif religieux en droit du travail et les ressources du droit du bien-être
Linguelet, Renaud ULg

in Journal des Tribunaux du Travail (2016)

L’obligation d’aménagement raisonnable pour cause de liberté de conscience et de religion peut se définir comme une obligation de nature juridique, applicable dans une situation discriminatoire ou mettant ... [more ▼]

L’obligation d’aménagement raisonnable pour cause de liberté de conscience et de religion peut se définir comme une obligation de nature juridique, applicable dans une situation discriminatoire ou mettant en cause la liberté religieuse d’un individu, qui a pour objectif d’aménager une norme ou une pratique de portée générale. Elle s’exerce dans les limites du raisonnable. Afin de saisir pleinement la portée du concept d’aménagement raisonnable pour motif religieux et ses conséquences en droit du travail, un détour par l’Amérique du Nord s’impose. Par la suite, cet article se focalise sur la possibilité de consacrer l’obligation d’aménagement raisonnable en droit belge. Pour ce faire, les enseignements à tirer du droit européen et communautaire sont mis en lumière, avant de terminer ce tour d’horizon par une analyse des ressources qu’offrent l’article 20, 5°, de la loi du 3 juillet 1978 relative aux contrats de travail ainsi que la législation relative aux risques psychosociaux telle qu’elle a été amendée lors de la réforme de 2014. [less ▲]

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See detailModulation du stress oxydant : nouveaux concepts pour de nouvelles applications
PINCEMAIL, Joël ULg

Scientific conference (2016, May 31)

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See detailI Am Very Sorry Sir! Breaking Bad News to Customers
Delcourt, Cécile ULg; GREMLER, Dwayne; GREER, Dominique

Conference (2016, May 31)

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See detailDie Deutschprachige Gemeinschaft nach der 6. Staatsreform
Bouhon, Frédéric ULg

Conference given outside the academic context (2016)

L'exposé présente les résultats d'une étude sur la Communauté germanophone après la sixième réforme de l'État, menée par l'auteur et deux collègues (étude publiée sous la forme d'un Courrier Hebdomadaire ... [more ▼]

L'exposé présente les résultats d'une étude sur la Communauté germanophone après la sixième réforme de l'État, menée par l'auteur et deux collègues (étude publiée sous la forme d'un Courrier Hebdomadaire du CRISP). Le texte de la conférence offre un résumé de la situation juridique et politique de la Communauté germanophone au milieu de l'année 2016. [less ▲]

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See detailStatics and dynamics of magnetocapillary bonds
Lagubeau, Guillaume; Grosjean, Galien ULg; Darras, Alexis ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016), 93

When ferromagnetic particles are suspended at an interface under magnetic fields, dipole-dipole interactions compete with capillary attraction. This combination of forces has recently given promising ... [more ▼]

When ferromagnetic particles are suspended at an interface under magnetic fields, dipole-dipole interactions compete with capillary attraction. This combination of forces has recently given promising results towards controllable self-assemblies as well as low-Reynolds-number swimming systems. The elementary unit of these assemblies is a pair of particles. Although equilibrium properties of this interaction are well described, the dynamics remain unclear. In this paper, the properties of magnetocapillary bonds are determined by probing them with magnetic perturbations. Two deformation modes are evidenced and discussed. These modes exhibit resonances whose frequencies can be detuned to generate nonreciprocal motion. A model is proposed that can become the basis for elaborate collective behaviors. [less ▲]

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