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See detailGenetic depletion of the dual specificity protein phosphatase DUSP3 promotes LLC Lung tumour metastasis
Vandereyken, Maud ULg; Amand, Mathieu ULg; Van Overmeire, Eva et al

Conference (2015, June)

DUSP3, also called Vaccinia-H1 Related (VHR) is a small dual specificity phosphatase dephosphorylating both tyrosine and serine/threonine phosphorylated residues. DUSP3 plays an important role in cell ... [more ▼]

DUSP3, also called Vaccinia-H1 Related (VHR) is a small dual specificity phosphatase dephosphorylating both tyrosine and serine/threonine phosphorylated residues. DUSP3 plays an important role in cell cycle regulation and is up-regulated in several human cancers. The physiological role of this phosphatase is, however, poorly understood. We have recently generated a DUSP3 knockout mouse by homologous recombination. The obtained mice have no spontaneous phenotype or pathology. However, DUSP3 deficiency prevented neo-vascularization of subcutaneously transplanted Matrigel plugs and Lung Lewis Carcinoma (LLC) tumours, suggesting an involvement of DUSP3 in tumour angiogenesis. Considering the importance of angiogenesis in metastatic formation, our study aimed to investigate the role of DUSP3 in metastatic dissemination. To do so, we used the LLC experimental metastasis model that shortcuts the intravasation/extravasation processes by injecting intravenously the LLC and the B16 (metastatic melanoma cell line) cells. Surprisingly, LLC, but not B16, lung metastasis developed twice faster in DUSP3-KO than WT mice. The enhanced LLC metastatic growth in DUSP3-/- mice was transferable to WT mice via DUSP3-/- bone marrow adoptive transfer, suggesting an involvement of the hematopoietic compartment in the observed phenotype. This was confirmed by a higher infiltration of neutrophils and macrophages in the lungs of DUSP3-KO compared to WT mice after LLC injection. This infiltration was correlated with higher expression of the chemokine receptor CCR2 in LLC-bearing DUSP3-KO lungs macrophages. Interestingly, LLC, but not B16 cells, were found to secrete high level of CCL2/MCP1, the CCR ligand chemokine. In line with this observation, we found that DUSP3-/- bone marrow derived-macrophages have a higher migration potential in response to LLC, but not B16, -conditionned medium. Altogether, our results suggest that DUSP3 plays an important role in metastatic dissemination/growth by a mechanism involving the control of CCR2-CCL2 chemoattraction axis in macrophages. [less ▲]

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See detailThe site of administration influences both the type and the magnitude of the immune response induced by DNA vaccine electroporation
Vandermeulen, G; Vanvarenberg, K; De Beuckelaer, A et al

in Vaccine (2015), 33

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See detailDynamic modeling of thermal systems using a semi-empirical approach and the ThermoCycle Modelica Library
Altés Buch, Queralt ULg; Dickes, Rémi ULg; Desideri, Adriano ULg et al

in Proceedings of the 28th International Conference on Efficiency, Costs, Optimization and Simulation of Energy Systems (2015, June)

This paper proposes an innovative approach for the dynamic modeling of heat exchangers without phase transitions. The proposed thermo-flow model is an alternative to the traditional 1D finite-volumes ... [more ▼]

This paper proposes an innovative approach for the dynamic modeling of heat exchangers without phase transitions. The proposed thermo-flow model is an alternative to the traditional 1D finite-volumes approach and relies on a lumped thermal mass approach to model transient responses. The heat transfer is modeled by the well-known Logarithmic Mean Temperature Difference approach, which is modified to ensure robustness during all possible transient conditions. The lumped parameter models are validated with references models and tested within a Concentrating Solar Power plant model. Results indicate that the developed lumped models are robust and computationally efficient, ensuring the convergence of the Newton Solver. They are significantly faster (~10-fold) than the traditional finite volume models, although a more extensive comparisons would be needed to confirm this figure. They are well suited to be integrated in larger system models, but are not appropriate for the simulation of detailed thermo-flow phenomena. [less ▲]

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See detailQuaternary prevention: first, do not harm - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-3

Clinical prevention, under the influence of public health, has been organised in a chronological manner since the middle of the 20th century. A paradigm shift from a chronological to a constructivist ... [more ▼]

Clinical prevention, under the influence of public health, has been organised in a chronological manner since the middle of the 20th century. A paradigm shift from a chronological to a constructivist relationship-based preventive pattern of care offers new insights into the practice of doctors. This paradigm shift brings to light the concept of quaternary prevention, a critical look at medical activities with an emphasis on the need not to harm. Quaternary prevention addresses the fundamental question of what constitutes too much or too little medicine. It is the fourth form of disease prevention, but also the fourth frame of action for family doctors [less ▲]

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See detailTeaching and learning Quaternary prevention
Gomes, Luis Enrique; Gusso, Gustavo; Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-14

This article presents an overview of different techniques and skills required for teaching and learning quaternary prevention (P4). It adopts the Expertise Model that defines the competences required in ... [more ▼]

This article presents an overview of different techniques and skills required for teaching and learning quaternary prevention (P4). It adopts the Expertise Model that defines the competences required in P4 for each level: novice, competent, proficient, and expert. This should be used as a step-wise roadmap for teachers in order to achieve high standard levels of performance. This is complemented by a list of methods used in teaching and assessment of learners’ performance and competence. By covering a range of learning and teaching issues, those who aim to teach quaternary prevention can explore the proposed framework. Quaternary prevention is a research and teaching fertile medical field that requires the integration of different areas such as health service organization, epidemiology, communication skills, and andragogy either at the macro or the micro levels health related activities. [less ▲]

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See detailThe words of prevention, part I: changing the model
Jamoulle, Marc ULg; Gavilan, Enrique; Cardoso, Raquel Val et al

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-9

ABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information ... [more ▼]

ABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information process in GP/FM by keeping in line with the main terms used in health care organization. Methods: Important keywords for GP/FM in the prevention domain were selected. Then, a search was carried out on the main sources in GP/FM databases, as well as in Medical Subject Heading and major terminological databases available online. Results and Discussion: There is discrepancy between the conceptual contents of major prevention models amongst the usual bibliographic sources of knowledge in GP/FM in particular and medicine in general. Conclusion: For GP/FM, distribution of preventive activities is now firmly established on a new constructivist model, privileging the doctor-patient relationships and introducing a cybernetic thinking on the health care activities with a special commitment to ethics and the positive duty of beneficence. [less ▲]

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See detailThe words of prevention, part II: ten terms in the realm of quaternary prevention
Jamoulle, Marc ULg; Gavilan, Enrique; Cardoso, Raquel Val et al

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-9

ABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to ... [more ▼]

ABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to quaternary prevention: (1) overinformation, (2) overdiagnosis, (3) medically unexplained symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening, (7) overtreatment, (8) shared decision making, (9) deprescribing, and (10) disease mongering. Methods: with the support of the laboratory team of the University of Rouen, France, which is dedicated to medical terminology and semantic relationships, it was possible to utilize a graphic user interface (called DBGUI) allowing the construction of links for each of chosen terms, and making automatic links to MeSH, if any. Those concepts are analyzed in their environment in current literature, as well as in their MeSH counterparts, if any, and related semantic online terminologies. Results and Discussion: The rules in terminological development aspire to cover the whole field of a concept and in the meantime, it helps to avoid the noise due to proxy and not exactly related issues. This refers to exhaustivity and specificity in information retrieval. Our finds show that referring to MeSH only in information retrieval in General Practice/Family medicine can induce much noise and poor adequacy to the subject investigated. Conclusion: Gathering concepts in specially prepared terminologies for further development of ontologies is a necessity to enter in the semantic web area and the era of distributed data. [less ▲]

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See detailEarly evolution of large microorganisms with cytological complexity revealed by microanalyses of 3.4 Ga organic-walled microfossils.
Sugitani; Mimura, K; Takeuchi, M et al

in Geobiology (2015)

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See detailA new formulation of state estimation in distribution systems including demand and generation states
Rousseaux, Patricia ULg; Toubeau, Jean-François; De Grève, Zacharie et al

in proceeedings of the 2015 Power Tech conference (2015, June)

Distribution system state estimation faces a major difficulty: the lack of real-time measurements. This imposes to add information, usually pseudo-measurements from historical data. This paper proposes a ... [more ▼]

Distribution system state estimation faces a major difficulty: the lack of real-time measurements. This imposes to add information, usually pseudo-measurements from historical data. This paper proposes a different, novel formulation of state estimation relying on the classification of loads into components (e.g. residential, commercial, etc.) and accounting for dispersed generation. The approach “by-passes” the use of pseudo-measurements by expressing the medium-voltage bus injections as functions of a small number of active power components at low-voltage level, treated as additional state variables. The injections at medium-voltage buses become equality constraints. A procedure to identify the above functions is detailed, which takes advantage of data collected by smart meters. [less ▲]

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See detailA dynamic simulation approach to identify additional reactive reserves against long-term voltage instability
Papangelis, Lampros ULg; Panciatici, Patrick; Debry, Marie-Sophie et al

in Proc. of IEEE PES 2015 PowerTech conference (2015, June)

A simple method is proposed to identify additional reactive reserves enabling to counteract long-term voltage instability after a large disturbance. In contrast to the many references based on power flow ... [more ▼]

A simple method is proposed to identify additional reactive reserves enabling to counteract long-term voltage instability after a large disturbance. In contrast to the many references based on power flow calculations, the method resorts to dynamic simulation. The post-disturbance system evolution is simulated in the presence of time-varying shunt susceptances with specified rate of change. This allows to deal with dynamic issues such as the required speed of the additional reactive power sources, or the onset of unstable electromechanical oscillations. Furthermore, a compromise is sought between the speed of action and the volume of additional compensation. The method is demonstrated on a detailed model of the Nordic test system. [less ▲]

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See detailModular modelling of combined AC and DC systems in dynamic simulations
Aristidou, Petros ULg; Papangelis, Lampros ULg; Guillaud, Xavier et al

in Proc. of IEEE PES 2015 PowerTech conference (2015, June)

A formulation is proposed in which an AC-DC system is modeled as a combination of AC grids, DC grids, injectors, AC two-ports and AC/DC converters, respectively. This modular modelling facilitates the ... [more ▼]

A formulation is proposed in which an AC-DC system is modeled as a combination of AC grids, DC grids, injectors, AC two-ports and AC/DC converters, respectively. This modular modelling facilitates the dynamic simulation of future complex AC/DC systems. Furthermore, it can be exploited by the solver, which performs less operations on components with lower dynamic activity, and offers parallel processing of the time simulation. This approach is illustrated on a test system in which a multi-terminal DC grid connects two asynchronous AC systems, allows frequency support between them, and acts as emergency control against AC voltage instability. [less ▲]

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See detailFrom the Guiding Principles on Internal Displacement to the Nansen Initiative: What the Governance of Environmental Migration Can Learn from the Governance of Internal Displacement
Gemenne, François ULg; Brücker, Pauline

in International Journal of Refugee Law (2015), 27(2), 245-263

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the ... [more ▼]

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the protection of these migrants is not adequately addressed in the international normative frameworks on migration. As a result, a growing number of scholars and advocacy groups have sought to create a special convention and/or an ad hoc status for these migrants, while others have contended that such a legal status is not the answer. As a result, the protection of environmental migrants is currently the subject of vigorous debates amongst scholars and policy-makers, and no clear solution is yet in sight. Research however has little considered the debates that surrounded the protection of those displaced within their countries (IDPs) in the 1990s. Both phenomena have sometimes overlapped, especially as environmental displacement is often internal. Yet, the debate on IDPs has had some significant success, in particular, the adoption of the Guiding Principles on Internal Displacement in 1998, and the signature of the Organization for African Unity’s Kampala Convention in 2009. This article argues that important lessons can be drawn from the protection of IDPs in order to inform the current debates on the protection of environmental migrants, as the political contexts and policy challenges associated with both crises of the migration regime are often similar. The article identifies such lessons and assesses the opportunities and caveats of applying a similar approach of soft law to environmental migration – and what would be needed to achieve it. [less ▲]

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See detailCrystal structure of arsenuranospathite from Rabejac, Lodève, France
Dal Bo, Fabrice ULg; Hatert, Frédéric ULg; Baijot, Maxime ULg et al

in European Journal of Mineralogy (2015), 27

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See detailReduced Order Model for Accounting for High Frequency Effects in Power Electronic Components
Paquay, Yannick ULg; Geuzaine, Christophe ULg; Hasan, Md. Rokibul et al

Poster (2015, June)

This paper proposes a reduced-order model of power electronic components based on the proper orthogonal decomposition. Starting from a full-wave finite-element model and several snapshots/frequencies, the ... [more ▼]

This paper proposes a reduced-order model of power electronic components based on the proper orthogonal decomposition. Starting from a full-wave finite-element model and several snapshots/frequencies, the reduced-order (RO) model is constructed. Local field values (e.g. magnetic flux density, electric current density, magnetic or electric field) and global quantities (e.g. characteristic complex impedance, joule losses) can be determined for the intermediate frequencies with a very low computational cost and high accuracy. Particular attention is paid to the choice of the most suitable snapshots by means of three different greedy algorithms, the performance of which is compared. We adopt an automatic greedy algorithm that depends only on the RO model. [less ▲]

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See detailNonlinear Interpolation on Manifold of Reduced Order Models in Magnetodynamic Problems
Paquay, Yannick ULg; Bruls, Olivier ULg; Geuzaine, Christophe ULg

Poster (2015, June)

Proper Orthogonal Decomposition (POD) is an efficient model order reduction technique for linear problems in computational sciences, recently gaining popularity in electromagnetics. However, its ... [more ▼]

Proper Orthogonal Decomposition (POD) is an efficient model order reduction technique for linear problems in computational sciences, recently gaining popularity in electromagnetics. However, its efficiency has been shown to considerably degrade for nonlinear problems. In this paper, we propose a reduced order model for nonlinear magnetodynamic problems by combining POD with an interpolation on manifolds, which interpolates the reduced bases to efficiently construct the desired solution. [less ▲]

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See detailAtmospheric pressure mode localization coupled resonators stiffness sensor
Montaseri, Mohammad; Xie, J.B.; Chang, Homglong et al

in Proceedings of Solid-State Sensors, Actuators and Microsystems (Transducers 2015) (2015, June)

This paper reports on a 3-DoF mode localization resonant sensor experimentally evaluated under atmospheric conditions. It was demonstrated that using amplitude ratio as an output signal, even when the ... [more ▼]

This paper reports on a 3-DoF mode localization resonant sensor experimentally evaluated under atmospheric conditions. It was demonstrated that using amplitude ratio as an output signal, even when the device is operated in air, yields a higher sensitivity compared to the frequency variation sensitivity when assuming vacuum conditions. [less ▲]

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See detailA novel resonant accelerometer based on model localization of weakly coupled resonators.
Zhang, Hemin; Yuan, W.Z.; Li, B.Y. et al

in Proceedings of Solid-State Sensors, Actuators and Microsystems (Transducers 2015) (2015, June)

This paper describes a novel MEMS resonant accelerometer based on two weakly coupled resonators (WCRs) using the phenomenon of mode localization. It is the first time that this principle is demonstrated ... [more ▼]

This paper describes a novel MEMS resonant accelerometer based on two weakly coupled resonators (WCRs) using the phenomenon of mode localization. It is the first time that this principle is demonstrated experimentally for an accelerometer. The measured relative shift in amplitude ratio (~312162 ppm/g) is 302 times higher than the shift in resonance frequency (~1035 ppm/g). [less ▲]

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See detailDo T2-hypointense GH-secreting pituitary adenomas behave differently under somatostatin analogues as primary therapy in acromegaly ?
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in The International Journal of The Romania Society of Endocrinology - Abstract book (2015, June)

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See detailFrom FIPA to gigantism
Beckers, Albert ULg

Scientific conference (2015, June)

Detailed reference viewed: 14 (0 ULg)