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See detailRoot System Markup Language: toward an unified root architecture description language
Lobet, Guillaume ULg; Pound, Michael; Diener, Julien et al

in Plant Physiology (2015)

The number of image analysis tools supporting the extraction of architectural features of root systems has increased over the last years. These tools offer a handy set of complementary facilities, yet it ... [more ▼]

The number of image analysis tools supporting the extraction of architectural features of root systems has increased over the last years. These tools offer a handy set of complementary facilities, yet it is widely accepted that none of these software tool is able to extract in an efficient way growing array of static and dynamic features for different types of images and species. . We describe the Root System Markup Language (RSML) that has been designed to overcome two major challenges: (i) to enable portability of root architecture data between different software tools in an easy and interoperable manner allowing seamless collaborative work, and (ii) to provide a standard format upon which to base central repositories which will soon arise following the expanding worldwide root phenotyping effort. RSML follows the XML standard to store 2D or 3D image metadata, plant and root properties and geometries, continuous functions along individual root paths and a suite of annotations at the image, plant or root scales, at one or several time points. Plant ontologies are used to describe botanical entities that are relevant at the scale of root system architecture. An xml-schema describes the features and constraints of RSML and open-source packages have been developed in several languages (R, Excel, Java, Python, C#) to enable researchers to integrate RSML files into popular research workflow. [less ▲]

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See detailA generic anisotropic continuum damage model integration scheme adaptable to both ductile damage and biological damage-like situations
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2015), 66

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations ... [more ▼]

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations. For this purpose a staggered time integration scheme in a finite strain framework is presented, together with an analytical consistent tangent operator. The only restrictive hypothesis is to work with an undamaged isotropic material, assumed here to follow a J2 plasticity model. The only anisotropy considered is thus a damage-induced anisotropy. The possibility to couple any damage rate law with the present algorithm is illustrated with a classical ductile damage model for aluminium, and a biological damage-like application. The later proposes an original bone remodelling law coupled to trabecular bone plasticity for the simulation of orthodontic tooth movements. All the developments have been considered in the framework of the implicit non-linear finite element code Metafor (developed at the LTAS/MN2L, University of Liège, Belgium - www.metafor.ltas.ulg.ac.be). [less ▲]

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See detailCan meandering flows in shallow rectangular reservoir be modelled with the 2D shallow water equations?
Peltier, Yann ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Engineering (2015)

In this article, the ability of the 2D shallow water equations to model meandering flows in shallow rectangular reservoirs is discussed. Four meandering flows, of various shallowness, were modelled using ... [more ▼]

In this article, the ability of the 2D shallow water equations to model meandering flows in shallow rectangular reservoirs is discussed. Four meandering flows, of various shallowness, were modelled using the academic flow model WOLF 2D, which includes a depth-averaged k- model accounting for the horizontal and vertical turbulent length-scales. The bottom friction was modelled with the Colebrook-White formula and different roughness heights were considered. A Proper Orthogonal Decomposition (POD) was applied to the simulation results to extract the behaviour of the main structures responsible for the meandering flow. The same POD analysis was also performed for the reference experimental flow fields, obtained by Large-Scale Particle Image Velocimetry. The first two POD modes obtained from the numerical simulations assuming a smooth bottom are in good agreement with the experimental modes in terms of energy, as well as temporal and spatial variations, whatever the shallowness. In contrast, the remaining simulated modes are not well rendered. The effect of an increased roughness height in the simulations is finally discussed. It leads to an improved reproduction of the first two modes and of the following modes, except when significant viscous effects govern in the flow. [less ▲]

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See detailPharmacodynamics, Efficacy and Safety of Sodium-Glucose Co-Transporter Type 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Mellitus.
Scheen, André ULg

in Drugs (2015), 75(1), 33-59

Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries ... [more ▼]

Inhibitors of sodium-glucose co-transporter type 2 (SGLT2) are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Several compounds are already available in many countries (dapagliflozin, canagliflozin, empagliflozin and ipragliflozin) and some others are in a late phase of development. The available SGLT2 inhibitors share similar pharmacokinetic characteristics, with a rapid oral absorption, a long elimination half-life allowing once-daily administration, an extensive hepatic metabolism mainly via glucuronidation to inactive metabolites, the absence of clinically relevant drug-drug interactions and a low renal elimination as parent drug. SGLT2 co-transporters are responsible for reabsorption of most (90 %) of the glucose filtered by the kidneys. The pharmacological inhibition of SGLT2 co-transporters reduces hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. The amount of glucose excreted in the urine depends on both the level of hyperglycaemia and the glomerular filtration rate. Results of numerous placebo-controlled randomised clinical trials of 12-104 weeks duration have shown significant reductions in glycated haemoglobin (HbA1c), resulting in a significant increase in the proportion of patients reaching HbA1c targets, and a significant lowering of fasting plasma glucose when SGLT2 inhibitors were administered as monotherapy or in addition to other glucose-lowering therapies including insulin in patients with T2DM. In head-to-head trials of up to 2 years, SGLT2 inhibitors exerted similar glucose-lowering activity to metformin, sulphonylureas or sitagliptin. The durability of the glucose-lowering effect of SGLT2 inhibitors appears to be better; however, this remains to be more extensively investigated. The risk of hypoglycaemia was much lower with SGLT2 inhibitors than with sulphonylureas and was similarly low as that reported with metformin, pioglitazone or sitagliptin. Increased renal glucose elimination also assists weight loss and could help to reduce blood pressure. Both effects were very consistent across the trials and they represent some advantages for SGLT2 inhibitors when compared with other oral glucose-lowering agents. The pharmacodynamic response to SGLT2 inhibitors declines with increasing severity of renal impairment, and prescribing information for each SGLT2 inhibitor should be consulted regarding dosage adjustments or restrictions in moderate to severe renal dysfunction. Caution is also recommended in the elderly population because of a higher risk of renal impairment, orthostatic hypotension and dehydration, even if the absence of hypoglycaemia represents an obvious advantage in this population. The overall effect of SGLT2 inhibitors on the risk of cardiovascular disease is unknown and will be evaluated in several ongoing prospective placebo-controlled trials with cardiovascular outcomes. The impact of SGLT2 inhibitors on renal function and their potential to influence the course of diabetic nephropathy also deserve more attention. SGLT2 inhibitors are generally well-tolerated. The most frequently reported adverse events are female genital mycotic infections, while urinary tract infections are less commonly observed and generally benign. In conclusion, with their unique mechanism of action that is independent of insulin secretion and action, SGLT2 inhibitors are a useful addition to the therapeutic options available for the management of T2DM at any stage in the natural history of the disease. Although SGLT2 inhibitors have already been extensively investigated, further studies should even better delineate the best place of these new glucose-lowering agents in the already rich armamentarium for the management of T2DM. [less ▲]

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See detailL’agentivité engagée chez Charles Taylor. De l’interprétation à l’évaluation de soi
Gauvry, Charlotte ULg

in Boccaccini, Federico; Cormann, Grégory (Eds.) Le soi agent (2015)

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See detailComplex dynamics of a nonlinear aerospace structure: numerical continuation and normal modes
Renson, Ludovic ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Nonlinear Dynamics (2015), 79(2), 1293-1309

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining ... [more ▼]

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining additional insight into the nonlinear dynamics that was observed experimentally, but also for uncovering additional nonlinear phenomena, such as quasiperiodic regimes of motion. Forced/unforced, damped/undamped numerical simulations are carried out using advanced techniques and theoretical concepts such as numerical continuation and nonlinear normal modes. [less ▲]

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See detailRethinking Vulnerability Analysis and Governance with Emphasis on a Participatory Approach
Rossignol, Nicolas ULg; Delvenne, Pierre ULg; Turcanu, Catrinel

in Risk Analysis : An Official Publication of the Society for Risk Analysis (2015), 35(1), 129-141

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An ... [more ▼]

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An analysis of the literature on vulnerability analysis allows us to formulate a threefold critique: first, vulnerability analysis has been treated separately in the natural and the technological hazards fields. This separation prevents vulnerability to unleash the full range of its potential, as it constraints appraisals into artificial categories and thus already closes down the outcomes of the analysis. Second, vulnerability analysis focused on assessment tools that are mainly quantitative, whereas qualitative appraisal is a key to assessing vulnerability in a comprehensive way and to informing policy-making. Third, a systematic literature review of case studies reporting on participatory approaches to vulnerability analysis allows us to argue that participation has been important to address the above, but it remains too closed down in its approach and would benefit from embracing a more open, encompassing perspective. Therefore, we suggest rethinking vulnerability analysis as one part of a dynamic process between opening-up and closing-down strategies, in order to support a vulnerability governance framework. [less ▲]

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See detailLa saveur des échanges culturels
Mescoli, Elsa ULg

in Medhoune, Ahmed; Lausberg, Sylvie; Martiniello, Marco (Eds.) et al L’immigration marocaine en Belgique. Mémoires et destinées (2015)

Elaborer une réflexion à propos des passages d’éléments et caractères d’une culture à l’autre implique une préoccupation académique qui oblige à donner une définition au concept de culture. La culture de ... [more ▼]

Elaborer une réflexion à propos des passages d’éléments et caractères d’une culture à l’autre implique une préoccupation académique qui oblige à donner une définition au concept de culture. La culture de n’importe quel groupe de personnes ne peut pas être réduite à une liste d’éléments, bien que souvent cela soit fait pour permettre le développement de certains discours et politiques. Les frontières entre une culture et l’autre semblent se briser, non seulement à cause de la rencontre constante des différents gens grâce à la mobilité concrète et à l’imagination dans le monde globalisé, mais aussi de ce qu’une « logique métisse » met en évidence : les cultures ne seraient que le résultat d’une invention arbitraire et fonctionnelle de spécificités à partir d’un syncrétisme originaire. L’analyse des échanges culturels se situe alors entre la fluidité d’un concept (culture lue, interprétée, écrite ou inventée) et la concrétude de faits complexes. Les habitudes alimentaires dans la diaspora marocaine que je traite dans cet article constituent un de ces faits, terrain où s’entrelacent éléments biologiques, questions économiques, goûts, fois, normes, traditions, changements et où la rencontre avec l’altérité culturelle déclenche des dynamiques dignes de grandes attentions. [less ▲]

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See detailDevelopment of the Lémann Index to assess digestive tract damage in patients with Crohn's disease
Pariente, B; Mary, JY; Danese, S et al

in Gastroenterology (2015), 148

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (2015)

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See detailBridging Space Weather to Planetary Environments
Plainaki; Milillo; Andriopoulou et al

Conference (2015)

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See detailP. Carruthers, "Pour une théorie dispositionnelle de la pensée d'ordre supérieur"
Dewalque, Arnaud ULg

in Dewalque, Arnaud; Gauvry, Charlotte (Eds.) Conscience et Représentation. Controverses récentes en philosophie de l'esprit (2015)

Traduction française du célèbre chapitre de Peter Carruthers, "HOP over FOR, HOT Theory". L'auteur y soutient que les théories représentationnelles de premier ordre (Dretske, Tye, et alii) et les théories ... [more ▼]

Traduction française du célèbre chapitre de Peter Carruthers, "HOP over FOR, HOT Theory". L'auteur y soutient que les théories représentationnelles de premier ordre (Dretske, Tye, et alii) et les théories actualistes de la pensée d'ordre supérieur (e.g., Rosenthal) se heurtent à deux sérieuses difficultés: l'incapacité à rendre compte des concepts d'expérience recognitionnels et l'incapacité à expliquer pourquoi certains états sont phénoménalement conscients et d'autres non. P. Carruthers introduit et défend une théorie alternative, d'après laquelle un état mental est phénoménalement conscient si et seulement s'il est mis à la disposition d'une pensée d'ordre supérieur possible. Cette théorie est baptisée théorie dispositionnelle de la pensée d'ordre supérieur ou "théorie du double contenu". [less ▲]

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See detailSeymour de Ricci (1881-1942)
Carlig, Nathan ULg

in Capasso, Mario (Ed.) Hermae. Scholars and Scholarship in Papyrology, IV (2015)

Portrait bio-bibliographique papyrologique de l'érudit franco-anglais Seymour de Ricci (1881-1942).

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See detailCorrélations entre différents tests destinés à évaluer la souplesse des ischio-jambiers
Demoulin, Christophe ULg; Wolfs, Sébastien ULg; Granado, Caroline et al

in Kinesitherapie Revue (2015), 15(158), 44-45

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See detail« Maladie, malheur et santé en terre étrangère. Les apports de l’anthropologie à la pratique professionnelle »
Razy, Elodie ULg

in Collectif (Ed.) « La santé dans un contexte de diversité culturelle. Quelles ressources pour les professionnels qui accompagnent ou orientent des personnes d’origine étrangère ? » (2015)

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See detail« La antropología de la infancia y de los niños: Historia de un campo, cuestiones metodológicas y perspectivas »
Razy, Elodie ULg

in Alvarado, Neyra; Pérez, Salvador (Eds.) Por una Antropología de la Infancia (2015)

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See detailAfrican Migrations in Childhood: Historical Roots, Contemporary Perspectives
Rodet, Marie; Razy, Elodie ULg

Book published by James Currey (2015)

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See detailComparaison de deux programmes d'étirements des ischio-jambiers en terme de maintien des gains en mobilité au suivi à deux mois
Demoulin, Christophe ULg; Wolfs, Sébastien ULg; Chevalier, Madeline et al

in Kinesitherapie Revue (2015), 15(158), 57-58

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See detailClimate Change and Tritrophic Interactions: Will Modifications to Greenhouse Gas Emissions Increase the Vulnerability of Herbivorous Insects to Natural Enemies?
Boullis, Antoine ULg; Francis, Frédéric ULg; Verheggen, François ULg

in Environmental Entomology (2015)

Insects are highly dependent on odor cues released into the environment to locate conspecifics or food sources. This mechanism is particularly important for insect predators that rely on kairomones ... [more ▼]

Insects are highly dependent on odor cues released into the environment to locate conspecifics or food sources. This mechanism is particularly important for insect predators that rely on kairomones released by their prey to detect them. In the context of climate change and, more specifically, modifications in the gas composition of the atmosphere, chemical communication-mediating interactions between phytophagous insect pests, their host plants, and their natural enemies is likely to be impacted. Several reports have indicated that modifications to plants caused by elevated carbon dioxide and ozone concentrations might indirectly affect insect herbivores, with community-level modifications to this group potentially having an indirect influence on higher trophic levels. The vulnerability of agricultural insect pests toward their natural enemies under elevated greenhouse gases concentrations has been frequently reported, but conflicting results have been obtained. This literature review shows that the higher levels of carbon dioxide, as predicted for the coming century, do not enhance the abundance or efficiency of natural enemies to locate hosts or prey in most published studies. Increased ozone levels lead to modifications in herbivore-induced volatile organic compounds (VOCs) released by damaged plants, which may impact the attractiveness of these herbivores to the third trophic level. Furthermore, other oxidative gases (such as SO2 and NO2) tend to reduce the abundance of natural enemies. The impact of changes in atmospheric gas emissions on plant–insect and insect–insect chemical communication has been under-documented, despite the significance of these mechanisms in tritrophic interactions. We conclude by suggesting some further prospects on this topic of research yet to be investigated. [less ▲]

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