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See detailRole of non-polyQ regions on the aggregation process by polyQ proteins into amyloid fibrils
Huynen, Céline ULg; Willet, Nicolas ULg; Buell, Alexander K et al

Poster (2014, October 18)

Nine neurodegenerative disorders, referred to as polyglutamine diseases and including Huntington’s disease, are associated with the abnormal expansion of a polyglutamine tract inside nine unrelated ... [more ▼]

Nine neurodegenerative disorders, referred to as polyglutamine diseases and including Huntington’s disease, are associated with the abnormal expansion of a polyglutamine tract inside nine unrelated proteins. This polyQ expansion is thought to be the major determinant in the development of neurotoxicity, triggering protein aggregation into amyloid fibrils. A large body of evidence however indicates that non-polyQ regions modulate the aggregation process triggered by polyQ expansions. The interplay between the polyQ tract and non-polyQ regions is complex and still not fully understood. In order to better understand it, we previously designed and characterized model polyQ proteins made of the beta-lactamase BlaP and a 23, 30, 55 or 79Q tract inserted in position 197 or 216. These chimeras recapitulate the aggregation properties of polyQ disease-associated proteins: there is a Q-threshold for the formation of amyloid fibrils, and above the threshold, the longer the polyQ, the faster the aggregation. Moreover, the structure of BlaP (native or unfolded) and the position of insertion of the polyQ tract (197 versus 216) influence their aggregation properties. In this work, (i) we discuss the role of the conformation of the host protein, BlaP, and of the location of the polyQ within BlaP on the different phases of amyloid fibril formation, the nucleation and elongation steps, using mainly quartz crystal microbalance (QCM), atomic force microscopy (AFM). Our results highlight a linear dependence of the polyQ length on the elongation rate whatever the insertion site and the conformation of BlaP. These two parameters however drastically influence the ability of a polyQ tract to trigger the nucleation and the elongation steps of amyloid fibril formation. (ii) Finally, we investigate the precise aggregation threshold and the modulating role of the N- and C-terminal polyQ flanking sequences in position 197 of BlaP by creating and characterizing new chimeras containing intermediate length polyQ tracts in position 197, or polyQ tracts inserted between two cleavage sites in position 197, respectively. We observe that the propensity to trigger the full process of amyloid fibril formation and its rate seems to be largely dependent on the polyQ length and on the polyQ flanking sequences. Altogether our results contribute to identify the important species and elements (polyQ or non-polyQ regions, monomers, oligomers or fibrils) during the aggregation process into amyloid fibrils to interfere with the latter associated with neurotoxicity. [less ▲]

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See detailA novel mutation of the luteinizing hormone/choionic gonadotrophin receptor gene leading to Leydig cell hypoplasia type I
Potorac, Iulia ULg; Rivero-Müller, Adolfo; Pintiaux, Axelle ULg et al

in Abstract book - 24th Meeting of the Belgian Endocrine Society (2014, October 18)

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See detailFamilial hypocalciuric hypercalcemia : a rare cause of recurrent pancreatitis
Daniel, Sara ULg; Potorac, Iulia ULg; MALAISE, Olivier ULg et al

in Abstract book - 24th Meeting of the Belgian Endocrine Society (2014, October 18)

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See detailCharacterization of paragangliomas : a single center cohort study
VROONEN, Laurent ULg; Maiga, Ibrahima ULg; PETROSSIANS, Patrick ULg et al

in Abstract book - 24th Meeting of the Belgian Endocrine Society (2014, October 18)

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See detailRèglements de juges : conséquences sur la peine et sur la saisine du juge de renvoi
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2014)

Le prévenu qui après avoir été condamné par défaut et sur opposition interjette seul appel de cette dernière décision ne peut voir sa situation aggravée quand bien même la juridiction d’appel s’est ... [more ▼]

Le prévenu qui après avoir été condamné par défaut et sur opposition interjette seul appel de cette dernière décision ne peut voir sa situation aggravée quand bien même la juridiction d’appel s’est déclarée incompétente provoquant de la sorte un règlement de juges qui se résout par son renvoi devant la cour d’assises. [less ▲]

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See detailEffet de l'expertise musicale sur la perception de la justesse vocale
Gosselin, Laura; Morsomme, Dominique ULg; Larrouy, Pauline ULg

Poster (2014, October 17)

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See detailAnalyse du point de vue des enseignants sur la mise en place de « Brain Break » dans l’enseignement primaire. Étude de cas
Cloes, Marc ULg; Mornard, Manhattan ULg

in Science et sports (2014, October 17), 29(Hors-série 1), 25

Children have a natural need of movement. It seems logical to develop processes that could be used during classroom teaching. Our study aims to test one didactic approach allowing primary school pupils to ... [more ▼]

Children have a natural need of movement. It seems logical to develop processes that could be used during classroom teaching. Our study aims to test one didactic approach allowing primary school pupils to express their movement need. [less ▲]

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See detailPratique de l’équimotricité© : motifs de participation et perception de l’impact
Saublens, Catherine; Cloes, Marc ULg

in Science et sports (2014, October 17), 29(Hors-série 1), 17

La littérature souligne toute l'importance du développement moteur chez les enfants. De nombreux parents s'efforcent de trouver, au sein de la communauté, des activités susceptibles de palier le manque d ... [more ▼]

La littérature souligne toute l'importance du développement moteur chez les enfants. De nombreux parents s'efforcent de trouver, au sein de la communauté, des activités susceptibles de palier le manque d'occasions de pratique de ces derniers. La participation à des séances au cours desquelles les enfants alternent des périodes d'activité physique sur un poney et au cours desquelles ils conduisent ce dernier est considérée par les parents comme très bénéfique à leur développement. [less ▲]

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See detailAn evaluation of anthropometric and conditional indicators for specific positions in youth women's volleyball played as a school sport
Joao, Paulo Vicente; Contiuga, Ioana; Pereira, Ana et al

in Science & Sports (2014, October 17), 29(Hors-série 1), 31

The present study aimed to identify anthropometric and functional characteristics of female volleyball players according to their specific in the match.

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See detailExpérimentation des « Brain Break » dans l’enseignement primaire. Avis des élèves
Cloes, Marc ULg; Mornard, Manhattan ULg

in Science & Sports (2014, October 17), 29(Hors-série 1), 52

L'école est identifiée comme un des piliers de la lutte contre la sédentarité des jeunes. Une société américaine (HOPSports) conçoit et diffuse des séquences de quelques minutes qui mettent en scène des ... [more ▼]

L'école est identifiée comme un des piliers de la lutte contre la sédentarité des jeunes. Une société américaine (HOPSports) conçoit et diffuse des séquences de quelques minutes qui mettent en scène des personnages, réalisant des activités à imiter en classe: les 'Brain Breaks' (BB). Ces videos ont été proposées pendant trois mois dans deux écoles primaires de la région liégeoise. L'opinion des élèves est positive mais leurs attitudes à l'égard de l'école et de l'activité physique ne change guère. [less ▲]

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See detailLa psychomotricité avec poney ou équimotricité© : vidéo
Saublens, Catherine; Cloes, Marc ULg

in Science & Sports (2014, October 17), 29(Hors-série 1), 11

Physical activity has a positive impact ont child's grow, on his global development and wellness. Implemented in 2007, equimotricity corresponds to motor development activities organized in a outdoor ... [more ▼]

Physical activity has a positive impact ont child's grow, on his global development and wellness. Implemented in 2007, equimotricity corresponds to motor development activities organized in a outdoor track where children act in teams of two. [less ▲]

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See detailL’équimotricité© : bases théoriques, principes d’action et constats informels
SAUBLENS, Catherine; Cloes, Marc ULg

in Science & Sports (2014, October 17), 29(Hors-série 1), 49

L'évolution actuelle de la société amène une dégradation du niveau de développement moteur et de condition physique des enfants. L'équimotricité© a été créée en 2007 et connait depuis lors un ... [more ▼]

L'évolution actuelle de la société amène une dégradation du niveau de développement moteur et de condition physique des enfants. L'équimotricité© a été créée en 2007 et connait depuis lors un développement important. Cette présentation fournit une description des modalités d'organisation de cette activité destinée à enrichir les opportunités de pratique des jeunes enfants. [less ▲]

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See detailLocal goat in Kabylie (Chemini and Bouzeguene)
Moula, Nassim ULg; Michaux, Charles ULg; Philippe, François-Xavier ULg et al

Poster (2014, October 17)

The livestock sector plays a dynamic role in the economic development of rural areas in Algeria. Due to its adaptation to harsh environments, goat breeding is practiced in many areas of the country. To ... [more ▼]

The livestock sector plays a dynamic role in the economic development of rural areas in Algeria. Due to its adaptation to harsh environments, goat breeding is practiced in many areas of the country. To the north, it is confined to mountainous areas, but the bulk of the workforce is left in the steppe and semi-desert areas. The goat population in Algeria reached 3.8 million heads, ranking second after sheep. The present work contributes to a better characterisation of local goat in Kabylie for production and reproduction traits. The study was conducted in the regions of Chemini (Bejaia province) and Bouzeguene (Tizi-Ouzou province). A survey was conducted in 29 herds. The results revealed that the overall mean of goats per households was 6.69 ± 2.97. The purposes of keeping goat in Chemini and Bouzguene was private consumption of milk (82.76%) and meat (68.97%) as well as for commercial exchange (62.07%). The Kabyle goat is small (male: 62.23 cm and female: 58.41 cm) with long hair. Its ears are drooping, its convex profile has a slightly pronounced nasal split and its coat colour ranges from dark brown to black. However, the crossbreeding with exotic breeds (mainly with Saanen goat), controlled or uncontrolled, increased the frequency of white coat. The average age at puberty in males was 6.93 ± 1.04 and 7.38 ± 0.94 months in females. The reported age at first kidding and kidding interval were 13.03 ± 0.87 months and 7.83 ± 1.29 months, respectively. [less ▲]

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See detailThe effect of the inclusion of Urtica dioica leaves meal in diets on growth performances and carcass characteristics of broiler
Moula, Nassim ULg; Philippe, François-Xavier ULg; Michaux, Charles ULg et al

Poster (2014, October 17)

The objective of this study was to evaluate the effects of the inclusion of Urtica dioica leaves meal in diets on growth performances and carcass characteristics of broiler chicken. The study was ... [more ▼]

The objective of this study was to evaluate the effects of the inclusion of Urtica dioica leaves meal in diets on growth performances and carcass characteristics of broiler chicken. The study was conducted from May to June 2014 in the area of Chemini (Algeria). In a completely randomized design, a total of 100 one-day-old broilers (industrial strain) were divided into 2 groups and 2 repetitions with 25 chickens each. Group 1 was the control group fed a standard commercial diet based on corn and soybean purchased on the local market, whereas the birds in group 2 were fed the nettle diet (control diet with addition of 2% of nettle). The animals were housed inside in experimental pens and fed ad libitum. The results showed that nettle inclusion significantly promotes growth performance of broilers at 42 days of age (1644.8 ± 45.5 vs. 1565.1 ± 45.5g; P<0.05). The broilers fed the nettle diet had higher thigh yield (26.0 ± 0.3 vs. 25.2 ± 0.3%; P<0.05) but lower abdominal fat yield (4.39 ± 0.16 vs. 3.90 ± 0.16%; P<0.05). No significant effect of the diet was observed for carcass yield (around 71.1%) and breast percentage (around 32.40%). The overall mortality was not significantly different (P>0.05) for any of the dietary regimens (around 20%). Feed conversion ratio of the two groups were very close (around 2.17). This experiment showed that dietary inclusion of Urtica dioica has positive effects on growth performance and carcass quality of broilers. [less ▲]

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See detailThe Effect of Urtica dioica Supplements on Egg Quality
Touazi, Leghel; Moula, Nassim ULg

Poster (2014, October 17)

Eggs are a rich source of lipids and proteins. Because of their low production cost, they represent a cheap source of animal proteins and lipids. recently, in Algeria, consumers’ interest are oriented of ... [more ▼]

Eggs are a rich source of lipids and proteins. Because of their low production cost, they represent a cheap source of animal proteins and lipids. recently, in Algeria, consumers’ interest are oriented of healthiness and dietetic values food. The purpose of this study was to investigate the effects a dietary supplement of Urtica dioica on laying hen's performance and egg quality. The study was conducted from may to june 2014 in the area of Chemini (Algeria). Sixty, 25-wk-old Lohmann Brown layers were randomly divided into 3 groups with 20 hens in each group. Group 1 was the control group fed a standard commercial diet based on corn and soybean, whereas the groups 2 and 3 were fed the control diet supplemented with 1% and 1.5% of nettle respectively. The hens were housed in cages in the same local and fed ad libitum. Fifty five eggs were sampled 4 times in each group from 25 to 27 weeks. A total of 220 eggs were examined. A series of measurements were carried out on each egg, namely egg weight, form index (egg shape), yolk to albumen ratio (Y:A), Yolk color, egg shell thickness, Haugh’s units. Egg weight, yolk color and Haugh Units (HU) were affected by age. Significant differences (P<0.05) were recorded between feeding type in total egg weight, yolk color and Haugh Units. The egg from group 2 proved to have a higher egg weight (57.67g; group 1: 55.41g; group 3: 56.70g; P<0.05), (33.4%), intermediate Yolk color (8.53; group 1: 9.03 ; group 3: 9.38; P<0.05) and HU (79.81; group 1: 80.85; group 3: 76.92). The results showed that the use of 1% and 1.5% of Urtica dioica, had positive effects on the color of yolk of laying hens. Using different levels of Urtica dioica could change the characteristics of egg and could meet the preferences of consumers for the intense color of the yolk. [less ▲]

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See detailEU Patent Package - The University Perspective
Antheunis, Nicole ULg

Conference given outside the academic context (2014)

What are the key issues of concern for European Universities with regards to the Unitary Patent and the Unified Patent Court

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