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See detailDouble stigmatization influence in oncogeriatry
Schroyen, Sarah ULg; Adam, Stéphane ULg; JERUSALEM, Guy ULg et al

in Psycho-oncology (2014, October 24)

Introduction Cancer is a major health problem widespread in elderly, which is inscribed in ageism context1. Negative influence of the vision that older people possess on aging on mental and physical ... [more ▼]

Introduction Cancer is a major health problem widespread in elderly, which is inscribed in ageism context1. Negative influence of the vision that older people possess on aging on mental and physical health2 is well established within “normal” aging. Consequently, we can ask ourselves what consequences age stigmas have in the realm of oncogeriatry. Moreover, cancerous patients face pathology-related stigmas because nowadays cancer still conveys a lot of negative representations. Method A group of 120 patients aged of 65 years old and more suffering from cancer (lung, breast or gynecological) will be followed during one year (0-3-6-12 months). Different instruments measuring quality of life, depression, symptoms, etc. are used as well as questions about their vision of aging and of cancer. Clinical parameters (weight, biologicals values, comorbidity…) are recorded too. Currently, we have 63 patients (31 breast cancer, 14 gynecological cancer and 18 lung cancer with distinction between smokers and non-smokers). Our analysis is only on the baseline at this moment, without any distinction between kinds of cancers. Results Double ANOVAs were used to analyze the data. A positive vision of aging is linked to a lower level of depression in comparison to a negative vision of aging (p = .04). Vision of pathology approach significance: less depression when vision is positive (p = .077). Concerning daily functioning (physical, emotional, social...), a positive vision of aging is related to a better functioning (p = .03) whereas vision of pathology has no effect. Eventually, a positive vision of aging and of cancer is related to a better quality of life (respectively p=.02, p=.002). Concerning clinical parameters, no results are observed. Conclusion These first results suggest that the vision patients have themselves of the age and of cancer is in relation with subjective mental and physical health. As we observe influence on vision of aging as well as pathology, we can talk about “double stigmatization”. Needless to say, more studies are needed to analyze the direction of these observation and longitudinal data analysis could bring some answers: is stigmatization provoke a less good mental and physical health or is it because I have health problem that I have a negative vision of aging and of my disease? 1. Penson, R. T., et al. (2004). The Oncologist, 9, 343-352. 2. Levy, B. (2009). Curr Dir Psychol Sci, 18, 332-336. [less ▲]

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See detailEnjeux de « Horizon 2020 » : Conséquences pour les chercheurs
Thirion, Paul ULg

Scientific conference (2014, October 24)

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See detailLe contrôle externe des services de renseignement en Belgique
Stans, David ULg

Scientific conference (2014, October 24)

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See detail“Metacognitive Mystery Tales at The Ohio State University”
Dechene, Antoine ULg

Scientific conference (2014, October 24)

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See detailThe marauder's map or the use of non-intrusive range laser scanners in the context of smart rooms
Pierard, Sébastien ULg

Scientific conference (2014, October 24)

Dans cette présentation, je vais expliquer comment des capteurs laser peuvent être utilisés pour réaliser différentes fonctionnalités importantes pour les environnements intelligents. Je montrerai comment ... [more ▼]

Dans cette présentation, je vais expliquer comment des capteurs laser peuvent être utilisés pour réaliser différentes fonctionnalités importantes pour les environnements intelligents. Je montrerai comment créer une carte précise et y représenter le mouvement de toutes les personnes, en particulier les trajectoires de leurs pieds. Celles-ci peuvent servir à identifier la personne observée, car chacune a sa propre démarche. Ceci ouvre des voies dans les domaines de la domotique, des environnements intelligents et de la sécurité. Les trajectoires de pieds ont également de nombreuses applications dans le domaine médical, en particulier pour la gériatrie, la kinésithérapie et la neurologie, ce que je détaillerai. Je démontrerai également que cette technologie permet de détecter les situations de piggybacking et de tailgating. Tout ceci étant rendu possible par une chaîne de traitement de signal minutieusement étudiée et par des techniques d'apprentissage automatique. [less ▲]

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See detailRetrievals of formaldehyde from ground-based FTIR and MAX-DOAS observations at the Jungfraujoch station and comparisons with GEOS-Chem and IMAGES model simulations
Franco, Bruno ULg; Hendrick, François; Van Roozendael, Michel et al

in Atmospheric Measurement Techniques. Papers in Open Discussion (2014), 7

As a ubiquitous product of the oxidation of many Volatile Organic Compounds (VOCs), formaldehyde (HCHO) plays a key role as a short-lived and reactive intermediate in the atmospheric photo-oxidation ... [more ▼]

As a ubiquitous product of the oxidation of many Volatile Organic Compounds (VOCs), formaldehyde (HCHO) plays a key role as a short-lived and reactive intermediate in the atmospheric photo-oxidation pathways leading to the formation of tropospheric ozone and secondary organic aerosols. In this study, HCHO profiles have been successfully retrieved from ground-based Fourier Transform Infrared (FTIR) solar spectra and UV-Visible Multi-AXis Differential Optical Absorption Spectroscopy (MAX-DOAS) scans recorded during the July 2010–December 2012 time period at the Jungfraujoch station (Swiss Alps, 46.5 N, 8.0 E, 3580ma.s.l.). Analysis of the retrieved products has revealed different vertical sensitivity between both remote sensing techniques. Furthermore, HCHO amounts simulated by two state-of-the-art Chemical Transport Models (CTMs), GEOS-Chem and IMAGESv2, have been compared to FTIR total columns and MAX-DOAS 3.6–8 km partial columns, accounting for the respective vertical resolution of each ground-based instrument. Using the CTMs outputs as intermediate, FTIR and MAX-DOAS retrievals have shown consistent seasonal modulations of HCHO throughout the investigated period, characterized by summertime maximum and wintertime minimum. Such comparisons have also highlighted that FTIR and MAX-DOAS provide complementary products for the HCHO retrieval above the Jungfraujoch station. [less ▲]

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See detailL’exemple historique dans la pensée de Machiavel et de Guichardin
Moreno, Paola ULg

Scientific conference (2014, October 23)

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See detailSafety Governance in Practice: A Vulnerability Approach
Rossignol, Nicolas ULg

Scientific conference (2014, October 23)

Scientists in many fields of research have developed models, theories and concepts attempting to grasp and manage dangers that are often difficult to concretely imagine. Their final objective is to ... [more ▼]

Scientists in many fields of research have developed models, theories and concepts attempting to grasp and manage dangers that are often difficult to concretely imagine. Their final objective is to maintain or improve the safety of the system considered. In this respect, the risk-based and the vulnerability-based approaches are different, yet complementary. After presenting the main forms taken by vulnerability approaches in the scientific literature, we elaborate on the potential of “opening-up” such an analysis through the use of a Science and Technology Studies (STS) vulnerability-based approach. We then present results from case studies concerning emergency planning, on the one hand, and an analysis of the perception of the REX system of SCK•CEN, on the other hand. We demonstrate how such an approach contributes to shed light on under-explored aspects of safety and provides a nuanced perspective on actual safety practices. As a conclusion, we propose further work directions to be followed. [less ▲]

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See detailReformage catalytique du toluène
Claude, Vincent ULg; Lambert, Stéphanie ULg; Courson, Claire

Poster (2014, October 23)

This poster summarizes results obtained for the catalytic reforming of tar in the oultlet gas of a biomass gasifier. All samples were synthesized with aluminum nitrate and an organosilane (EDAS) in order ... [more ▼]

This poster summarizes results obtained for the catalytic reforming of tar in the oultlet gas of a biomass gasifier. All samples were synthesized with aluminum nitrate and an organosilane (EDAS) in order to enhance the metallic dispersion and surface area. Three different compositions have been studied (Al2O3-SiO2; Al2O3-SiO2+2%wt Ni; Al2O3-SiO2+10%wt Fe). The catalytic tests highlight the fact that the sample containing 2%Ni wt is the more appropriate in our conditions. [less ▲]

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See detailProduction de biohydrogène à partir de biomasses
Hiligsmann, Serge ULg

Scientific conference (2014, October 23)

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See detailTraining alters the innate immune response in the lower airway of horses
Frellstedt, Linda ULg

Doctoral thesis (2014)

Many human and animal studies have examined various markers of the innate and/or adaptive immunity in association with exercise and have come to the general conclusion that exercise, either acute or ... [more ▼]

Many human and animal studies have examined various markers of the innate and/or adaptive immunity in association with exercise and have come to the general conclusion that exercise, either acute or chronic, modifies the immune response. Regular moderate exercise has beneficial and protective effects on immunity because it results in a balance of pro- and anti-inflammatory effects. This balance may be disturbed during exhaustive exercise, such as that experienced during competition and overtraining, resulting in immunosuppression. Humans frequently suffer from upper respiratory tract infections after prolonged intense exercise, whereas horses suffer primarily from lower airway inflammation and/or infection. The underlying mechanism for this difference remains unknown at this time. The sampling of different cell types is limited in humans and therefore, these studies focus on the evaluation of cells in peripheral blood or markers in saliva. Two groups of researchers in human sports medicine have compared populations of sedentary and regularly exercising people. The expression of Toll-like receptors (TLRs) 1, 2, 3 and 4 was decreased in peripheral blood monocytes in exercising subjects. This altered expression of TLRs was also associated with a lower production of pro-inflammatory cytokines (IL-6, IL-1α, TNF-α). Regular exercise induced circulating anti-inflammatory cytokines (IL-10, IL-6) and, therefore, limited the effects of pro-inflammatory cytokines. The first line of defense in the airways is provided by pulmonary alveolar macrophages and bronchial epithelial cells. Strenuous exercise impairs the viability of bronchial epithelial cells, reduces the viral defense mechanisms, and decreases oxidative burst activity of pulmonary alveolar macrophages. The altered immune response in association with exercise/training does not only lead to an increased risk for infection but may also cause the development of allergies and chronic inflammation in the lower airway. This may explain why young equine athletes frequently suffer from Inflammatory Airway Disease (IAD). The etiology of IAD remains unknown but an association with subclinical viral infections as well as inflammatory stimuli from the environment has been suspected. The objective of this work was to increase our knowledge of immune mechanisms in young equine athletes by evaluating the effect of acute exercise and training on the innate immune responses of pulmonary alveolar macrophages (PAM), bronchial epithelial cells (BEC) and monocytes. The hypothesis was that exercise and training modify the TLR mRNA expression as well as the production of pro-inflammatory cytokines and interferons in these three cell types. Eight Standardbred horses were studied over a period of 9 months during which they were acclimatized, trained and deconditioned. Standardized exercise tests were performed regularly and biological samples (blood, bronchoalveolar lavages, and biopsies of the bronchial epithelium) were taken at defined intervals in order to allow a longitudinal evaluation of the different parameters. Monocytes, PAM and BEC were harvested and analyzed. The expression of TLR3 was decreased in equine PAM and monocytes after a period of training, but not after a single strenuous exercise session. In addition, the expression of TLR4 was increased in equine monocytes after training. The production of TNF-α and IFN-β was also examined in PAM and monocytes ex vivo after the stimulation with different TLR ligands. The production of these cytokines was reduced in PAM after a defined period of training and remained decreased for three months thereafter. In contrast, the synthesis of TNF-α was increased after a period of training in equine monocytes and remained increased thereafter. In a second study, a model for the culture of equine bronchial epithelial cells (EBEC) was developed which allowed us to evaluate the effect of exercise and training on the innate immune response of these cells. Acute exercise or training did not alter the TLR mRNA expression in EBEC. The production of IFN-β was increased in EBEC from trained horses after stimulation with a TLR3 ligand. Concurrently, the secretion of TNF-α and IL-6 was impaired in EBEC from trained horses after the stimulation with TLR2 and TLR3 ligands. This study focused on a single aspect of the innate immunity in horses, gaining knowledge of the TLR expression in three cell types and their response to specific TLR agonists. These results have to be considered in the global context of the innate immunity remembering that they represent only a small part of the complex immune system. Only one type of training (Standardbred race training) and one model of acute exercise (standardized exercise test on a treadmill) were evaluated in this study. This should be considered when drawing conclusions, because it is currently understood that the effects on immune responses vary with different types, intensity and duration of exercise and/or training. Nonetheless, this work has established that a local immunosuppression develops within the lungs in trained horses, and may explain the increased susceptibility of exercising horses to pulmonary viral infections. This local immunosuppression is associated with an increased potential of monocytes to produce pro-inflammatory cytokines when challenged with pathogens. The effects of exercise on innate immunity are complex and further studies are needed to continue the work in this field. In addition to the response to training in young sport horses, a number of environmental factors associated with their nutrition and housing may play important roles in the development of pulmonary infections and inflammation (e.g. IAD). To confirm the significance of the presented results, it would be interesting to investigate the innate immune response in trained horses when challenged with equine pathogens, such as equine influenza and equine herpesviruses. The ultimate goal of this work and other studies in the future is to develop immuno-modulating molecules that could be used for the prevention and treatment of equine respiratory diseases. [less ▲]

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See detailThe effect of Brand Anthropomorphism on Self-Disclosure
Gretry, Anaïs ULg; Horváth, Csilla; Belei, Nina et al

Conference (2014, October 23)

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See detailThe Initial Upper Paleolithic in Northeast Asia: toward the definition of a techno-complex
Zwyns, N.; Teyssandier, N.; Izuho, M. et al

Conference (2014, October 23)

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See detailUniversité : Les interactions possibles avec l’enseignement non-universitaire
Winand, Jean ULg

Conference (2014, October 23)

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See detailProblèmes du plurilinguisme dans l'antiquité gréco-romaine
Rochette, Bruno ULg

Scientific conference (2014, October 23)

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See detailMontage de projets de Recherche et d’Innovation : A la recherche de financements
Hiligsmann, Serge ULg

Scientific conference (2014, October 23)

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See detailEvolution des eucaryotes : l'éclairage de la phylogénie moléculaire
Baurain, Denis ULg

Conference (2014, October 23)

Ce cours-conférence propose d'examiner l'origine et l'évolution des eucaryotes au travers de la biologie, la géologie et la paléontologie. Les eucaryotes forment un des trois domaines de la vie, et ... [more ▼]

Ce cours-conférence propose d'examiner l'origine et l'évolution des eucaryotes au travers de la biologie, la géologie et la paléontologie. Les eucaryotes forment un des trois domaines de la vie, et comprennent les animaux (dont les êtres humains), les plantes et les champignons, mais surtout une énorme majorité de protistes (eucaryotes unicellulaires) dont la diversité reste encore en partie à explorer. De grandes questions restent à élucider quant à l'origine du domaine Eucarya, sa position au sein de l'arbre de la vie, et les modalités et conditions de diversification et d'évolution depuis au moins 1,8 milliards d'années. La première leçon abordera l'origine de la cellule eucaryote, en discutant les différentes hypothèses existantes et la nature de LECA (Last Eucaryotic Common Ancestor). Comment tester ces hypothèses avec de nouvelles approches ? Comment révéler la diversité actuelle des eucaryotes encore en partie inexplorée et quelles réponses peut-elle apporter ? La seconde leçon présentera d'abord l'éclairage de la phylogénie moléculaire : comment utiliser les informations conservées dans le matériel génétique, pour mieux comprendre l'évolution des eucaryotes ? Quelles sont les possibilités et les limitations de la phylogénomique et des horloges moléculaires ? On présentera ensuite les informations enregistrées dans le registre fossile du Précambrien. Comment reconnaitre les eucaryotes fossiles, les étudier, et reconstruire leur évolution et diversification dans les conditions paléoenvironnementales depuis au moins 1,8 milliards d'années ? Ces deux leçons donneront donc un aperçu de l'état des connaissances, des nouvelles méthodes utilisées, et des grandes énigmes à résoudre à propos de notre domaine Eucarya. [less ▲]

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See detailDebatte über Kollaboration. Tristes Spektakel
Brüll, Christoph ULg

Article for general public (2014)

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