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See detailRevisiting the origin and diversification of vascular plants through a comprehensive Bayesian analysis of the fossil record
Silvestro, Daniel; Cascales - Miñana, Borja ULg; Bacon, Christine D. et al

in New Phytologist (in press)

Plants have a long evolutionary history, during which mass extinction events dramatically affected Earth’s ecosystems and its biodiversity. The fossil record can shed light on the diversi- fication ... [more ▼]

Plants have a long evolutionary history, during which mass extinction events dramatically affected Earth’s ecosystems and its biodiversity. The fossil record can shed light on the diversi- fication dynamics of plant life and reveal how changes in the origination–extinction balance have contributed to shaping the current flora. We use a novel Bayesian approach to estimate origination and extinction rates in plants throughout their history. We focus on the effect of the ‘Big Five’ mass extinctions and on estimating the timing of origin of vascular plants, seed plants and angiosperms. Our analyses show that plant diversification is characterized by several shifts in origination and extinction rates, often matching the most important geological boundaries. The estimated origin of major plant clades predates the oldest macrofossils when considering the uncertainties associated with the fossil record and the preservation process. Our findings show that the commonly recognized mass extinctions have affected each plant group differently and that phases of high extinction often coincided with major floral turnovers. For instance, after the Cretaceous–Paleogene boundary we infer negligible shifts in diversification of non-flowering seed plants, but find significantly decreased extinction in spore-bearing plants and increased origination rates in angiosperms, contributing to their current ecological and evolutionary dominance. [less ▲]

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See detailRelire Durkheim à partir de Zola : Ce que le roman naturaliste fait à la sociologie du suicide de Durkheim
Ledent, David ULg

in Le suicide : question individuelle ou question sociétale ? (in press)

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See detailLe partage du sensible
Havelange, Carl ULg

in Fritz, Jean-Marie; Duhl, Olga (Eds.) Les cinq sens entre Moyen Age et Renaissance (in press)

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See detailLiège de 1914 à 1927 : mort et résurrection d’un bassin industriel
Pirot, Pascal ULg; Peters, Arnaud ULg; Destatte, Julien ULg

in Actes du colloque: Guerres mondiales et bassins industriels en territoire occupé (1900-1950), Maubeuge, 20-21 novembre 2014 (titre provisoire) (in press)

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See detailDiversity patterns of the vascular plant group Zosterophyllopsida in relation to Devonian palaeogeography
Cascales - Miñana, Borja ULg; Meyer-Berthaud, Brigitte

in Palaeogeography, Palaeoclimatology, Palaeoecology (in press)

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See detailConclusion. De nouvelles approches pour repenser l’(in)sécurité
Wintgens, Sophie ULg; Grandjean, Geoffrey ULg; Vanhaeren, Stéphanie ULg

in Wintgens, Sophie; Grandjean, Geoffrey; Vanhaeren, Stéphanie (Eds.) L’insécurité en question. Définition, enjeux et perspectives (in press)

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See detailIntroduction. L’(in)sécurité : entre représentations et perceptions des concepts
Grandjean, Geoffrey ULg; Wintgens, Sophie ULg; Vanhaeren, Stéphanie ULg

in Wintgens, Sophie; Grandjean, Geoffrey; Vanhaeren, Stéphanie (Eds.) L’insécurité en question. Définition, enjeux et perspectives (in press)

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See detailL'insécurité en question. Définition, enjeux et perspectives
Wintgens, Sophie ULg; Grandjean, Geoffrey ULg; Vanhaeren, Stéphanie ULg

Book published by Presses Universitaires de Liège (in press)

Ces dernières années, l’analyse et les pratiques de la sécurité et de l’insécurité ont fortement évolué sous l’influence de plusieurs facteurs fortement imbriqués, tels que le déclin de la souveraineté ... [more ▼]

Ces dernières années, l’analyse et les pratiques de la sécurité et de l’insécurité ont fortement évolué sous l’influence de plusieurs facteurs fortement imbriqués, tels que le déclin de la souveraineté nationale, l’accroissement de l’intensité des interactions transnationales ou encore l’éclatement conflictuel sous-tendu par des dynamiques identitaires. Ces constats et les représentations qui leur sont associées ont enjoint un réexamen de la manière dont la sécurité et l’insécurité se pensent et se pratiquent. Inscrit au cœur de ce double questionnement contemporain, cet ouvrage met en question la définition et les enjeux liés aux dynamiques actuelles d’(in)sécurité tout en proposant de nouvelles perspectives. Privilégiant les études empiriques et les approches originales en termes de politique interne et/ou externe, il repose sur trois axes de recherche transversaux : la (re)définition des concepts de sécurité et d’insécurité à l’heure de la globalisation ; les enjeux inhérents aux pratiques (in)sécuritaires et aux sentiments d’(in)sécurité qui les fondent ; les réponses à apporter aux questions de sécurité et d’insécurité. Complémentaire aux analyses disciplinaires classiques de ces objets de recherche en Science politique, cet ouvrage livre un regard neuf sur des thématiques plus que jamais d’actualité. [less ▲]

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See detailLe faussaire
Havelange, Carl ULg

in Durante, Erica (Ed.) De l'humain au post-humain: le double et ses récits (in press)

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See detailProgress on research on rodents and rodent-borne zoonoses in Southeast Asia
Blasdell, Kim; Bordes, Frédéric; Chaisiri, Kittipong et al

in Wildlife Research (in press)

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne ... [more ▼]

This review aims to synthesize the knowledge on the taxonomy of Southeast Asian murine rodents and the challenges associated with the identification of habitat preferences and associated rodent-borne diseases. Recent studies concerning the Rattini tribe have identified unclear species boundaries that would benefit from further investigation. The development of barcoding may allow more accurate identification of rodents, specifically for complex species. However, knowledge on the distribution and habitat specializations of many common murine rodents is still scarce, particularly regarding the specific habitat preferences of most synanthropic rodent species (Rattus tanezumi or Rattus exulans). Several studies have analyzed the prevalence of major rodent-borne diseases in Southeast Asia and it appears that the greatest risk of rodent zoonoses are in the lowland rainfed and irrigated landscapes, generally in and around rice fields. [less ▲]

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Rozet, Eric

in Journal of Biopharmaceutical Statistics (in press)

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedure that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure Design Space and from it, control strategy can be set. [less ▲]

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See detailImaging myeloma and related monoclonal plasma cell disorders: Still room for standard radiography?
WITHOFS, Nadia ULg; Nanni, Cristina; Fanti, Stefano et al

in Clin.Translat.Imaging (in press)

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial ... [more ▼]

A majority of multiple myeloma patients present with osteolytic bone lesions that can cause bone pain, fractures or hypercalcaemia. Correct identification of these lesions is important in the initial assessment of the disease. Although the radiological skeletal survey is the gold standard to detect bone osteolytic lesions, it may miss small bone lesions or lesions located in the spine or pelvis due to the superimposed images of soft tissues. These limitations propelled newer imaging techniques such as positron emission tomography combined with computed tomography (PET/CT) and magnetic resonance imaging (MRI) in the diagnosis of multiple myeloma. In addition, 18F-fluorodeoxyglucose PET/CT and MRI have prognostic value and can be used to monitor disease. This review discusses the additional value of PET/CT and MRI in the management of MM. [less ▲]

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See detailSafety and efficacy of azacitidine in Belgian patients with high-risk myelodysplastic syndromes, acute myeloid leukaemia, or chronic myelomonocytic leukaemia: results of a real-life, non-interventional post-marketing survey
Beguin, Yves ULg; Selleslag, Dominik; Meers, Stef et al

in Acta Clinica Belgica (in press)

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real ... [more ▼]

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real-life setting. Treatment response, dose, and schedule were assessed. Methods: This non-interventional, post-marketing survey included 49/50 patients receiving azacitidine at 14 Belgian haematology centres from 2010–2012. Treatment-emergent adverse events (TEAEs), including treatment-related TEAEs, and serious TEAEs (TESAEs) were recorded throughout the study. Treatment response [complete response (CR), partial response (PR), haematological improvement (HI), stable disease (SD), treatment failure (TF)) and transfusion-independence (TI) were evaluated at completion of a 1-year observation period (1YOP) or at treatment discontinuation, and overall survival (OS), at study conclusion. Results: The median age of patients was 74.7 (range: 43.9–87.8) years; 69.4% had MDS, 26.5% had primary or secondary AML, and 4.1% had CMML. Treatment-related TEAEs, grade 3–4 TEAEs, and TESAEs were reported in 67.3%, 28.6%, and 18.4% of patients, respectively. During 1YOP, patients received a median of 7 (1–12) treatment cycles. Treatment response was assessed for 38/49 patients. Among MDS and CMML patients (n529), 41.4% had CR, PR, or HI, 41.4% had SD, and 17.2% had TF. Among AML patients (n59), 44.4% had CR or PR, 33.3% had SD, and 22.2% had TF. TI was observed in 14/32 (43.8%) patients who were transfusion-dependent at baseline. Median (95% confidence interval) OS was 490 (326–555) days; 1-year OS estimate was 0.571 (0.422–0.696). Conclusions: Our data support previous findings that azacitidine has a clinically acceptable safety profile and shows efficacy. [less ▲]

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See detailThe use of mesenchymal stromal cells in solid organ transplantation
GREGOIRE, Céline ULg; DETRY, Olivier ULg; Jouret, François ULg et al

in The Biology and Therapeutic Applications of Mesenchymal Cells (in press)

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See detailThe role of mesenchymal stem cells in the treatment of ulcerative colitis and Crohn's disease
GREGOIRE, Céline ULg; Louis, Edouard ULg; BRIQUET, Alexandra ULg et al

in The Biology and Therapeutic Applications of Mesenchymal Cells (in press)

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See detailSignes dans les textes, texte sur les signes. Actes du Colloque international. Liège, 6-7 septembre 2013.
Macedo, Gabriel ULg; Scappaticcio, Maria Chiara

Book published by Presses Universitaires de Liège (in press)

Proceedings of the international conference held at the University of Liège in 2013. Contributions on the subject of ponctuation, accentuation, critical and lectional signs in Greek and Latin texts.

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See detailJuvenal in Antinoë. Paleographic and Contextual Observations on P.Ant. s.n.
Macedo, Gabriel ULg

in Urbanik, Jakub (Ed.) Proceedings of the 27th International Congress of Papyrology. Warsaw, 29 July - 3 August 2013 (in press)

Paleographic and contextual study of the only Juvenal manuscript found in Egypt.

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See detailTextes sur les signes: les sources latines
Macedo, Gabriel ULg

in Macedo, Gabriel; Scappaticcio, Maria Chiara (Eds.) Signes dans les textes, textes sur les signes. Actes du colloque international. Liège, 6-7 septembre 2013. (in press)

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