MDRD Versus CKD_EPI equation to estimate glomerular filtration rate in kidney transplant recipients

in Transplantation (2013), 95(10),

Background. The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by ... [more ▼]

Background. The new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-based equation was developed to address the systematic underestimation of the glomerular filtration rate (GFR) by the Modification of Diet in Renal Disease (MDRD) Study equation in patients with a relatively well-preserved kidney function. The performance of the new equation for kidney transplant recipients is discussed. Methods. We analyzed the performances of the CKD-EPI equation in comparison with the MDRD Study equation in 825 stable kidney transplant recipients. Bias, precision, and accuracy within 30% of true GFR were determined. GFR was measured by urinary clearance of inulin (n=488) and plasma clearance of 51Cr-EDTA (n=337). Results. Mean measured GFR (mGFR) was 50T19 mL/min/1.73 m2. On the whole cohort, bias was significantly lower for MDRD Study equation compared with CKD-EPI creatinine. This superiority translates into a better accuracy (80% and 74% for the MDRD and CKD-EPI creatinine, respectively). The best performance of the MDRD Study equation is confirmed both in the subgroups of patients with mGFR G60 mL/min/1.73 m2 and between 60 and 90 mL/min/1.73 m2. For mGFR 990 mL/min/1.73 m2, there were no significant differences between the two equations in terms of performance. Conclusions. The CKD-EPI creatinine equation does not offer a better GFR prediction in renal transplant patients compared with the MDRD Study equation, even in the earlier CKD stages. [less ▲]

Blattmaske. Figure du rinceau peuplé dans les mosaïques d'Asie Mineure

Scientific conference (2013, May 25)

Lesion size effect on variability in PET quantification in multicenter trials

Poster (2013, May 25)

Le rôle de l’usage de l’ordinateur dans le travail scolaire des apprenants : Opinions des élèves des lycées Général Leclerc et bilingue de Yaoundé (Cameroun)

in Dili Palai/Etuge Apuge, Clément/Michael (Ed.) Langages, Littérature et Éducation au Cameroun (2013)

Cet article vise à cerner autrement le rôle de l’usage de l’ordinateur dans le travail scolaire des élèves. Elle utilise à cet effet une démarche centrée sur les apprenants, c’est-à-dire sur l’examen de ... [more ▼]

Cet article vise à cerner autrement le rôle de l’usage de l’ordinateur dans le travail scolaire des élèves. Elle utilise à cet effet une démarche centrée sur les apprenants, c’est-à-dire sur l’examen de leurs opinions (ce qu’ils pensent et disent) sur ce sujet. En analysant les discours tenus par les élèves des lycées Général Leclerc et bilingue de Yaoundé sur cette question, ce travail montre que pour eux, l’usage des TIC produit une réelle valeur ajoutée pédagogique. Mais ces potentialités résultent d’une combinaison de plusieurs facteurs concernant l’élève, l’enseignant et la structure scolaire. [less ▲]

The role of economic estate in territorial competitiveness: the case of Wallonia

Scientific conference (2013, May 24)

Belgium’s ordinary landscapes seen by Belgians

Conference (2013, May 24)

Conclusions

Conference (2013, May 24)

Des barricades au no man’s land. Paris et la guérilla urbaine de la RAF

Conference (2013, May 24)

Expliquer et illustrer Prospéro. Suivre le marqueur temporel "le-pire-est-à-venir" au sein des agendas politiques climatiques belges (1980-2012)

Conference (2013, May 24)

Variabilité de la respiration hétérotrophe du sol dans des écosystèmes agricoles: Analyse à différentes échelles spatiales et temporelles.

Doctoral thesis (2013)

Soil heterotrophic respiration (HR) was studied at different spatial and temporal scales in agricultural ecosystems in Belgium (loamy region). Results from both laboratory and field experiments conducted ... [more ▼]

Soil heterotrophic respiration (HR) was studied at different spatial and temporal scales in agricultural ecosystems in Belgium (loamy region). Results from both laboratory and field experiments conducted at short and long timescales were analysed with the aim to better understand the influence of driving variables such as temperature, substrate input quantity and quality on HR. Both empirical and semi-mechanistic models were used in order to help interpret experimental results. Our observations showed that temperature is an important HR driving variable in agricultural ecosystems in temperate regions. HR sensitivity to temperature, characterized by a Q10 differing from 2 in our experiments, was very likely influenced by substrate availability and quality. The impact of these last two factors was however never observed through our measurements. Good agreement between modelled and observed CO2 fluxes in the incubation experiment, where carbon substrate was limited, suggested that temperature played a role both directly (enzymatic response) and indirectly (labile carbon stock depletion) at a relatively short term, and confirmed the hypothesis of occurrence of abiotic fluxes linked to the presence of carbonates in the samples taken from a limed agricultural field. Crop residue management (in both quantity and quality), as characterized by relatively low input levels in our experiment, influenced soil carbon stocks in the long term. However, HR, microbial biomass, labile carbon and metabolic diversity were not affected by the investigated treatments. Besides, results from both soil carbon budgets and short term HR measurements showed that supposedly large differences were likely to be reduced due to the relatively large proportion of root residues, weeds and residues unexported at harvest. [less ▲]