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See detailOutcome after failure of allogeneic hematopoietic stem cell transplantation in children with acute leukemia: a study by the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Rorhlich; Roux, C; Tifratene, K et al

in Bone Marrow Transplantation (in press)

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (SCT) contributes to improved outcome in childhood acute leukemia (AL). However, therapeutic options are poorly defined in case of post-transplantation relapse. We aimed to compare treatment strategies in 334 consecutive children with acute leukemia relapse or progression after SCT in a recent ten-year period. Data could be analyzed in 288 patients (157 ALL, 123 AML and 8 biphenotypic AL) with a median age of 8.16 years at transplantation. The median delay from first SCT to relapse or progression was 182 days. The treatment consisted in chemotherapy alone (n=108), chemotherapy followed by second SCT (n=70), supportive/palliative care (n=67), combination of chemotherapy and DLI (n=30), or isolated reinfusion of donor lymphocytes (DLI) (n=13). The median OS duration after relapse was 164 days and differed according to therapy: DLI after chemotherapy = 385 d, second allograft = 391d, chemotherapy = 174d, DLI alone = 140d, palliative care = 43d. A second SCT or a combination of chemotherapy and donor lymphocytes infusion yielded similar outcome (HR=0.85, p=0.53) unlike chemotherapy alone (HR 1.43 p=0.04), palliative care (HR=4.24, p<0.0001) or isolated DLI (HR=1,94, p<0.04). Despite limitations in this retrospective setting, strategies including immunointervention appear superior to other approaches, mostly in AML. [less ▲]

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See detailThe clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study
Van Obbergh, F; Knoops, L; Devos, T et al

in Clinical Biochemistry (in press)

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice ... [more ▼]

This retrospectivemulticenter study in patientswith chronic myeloid leukemia in chronic phasewas undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given at a fixed 400mg daily dose. A significant inverse relationship of imatinib concentration with the patients' weight was observed (Pearson's test: p=0.02,R2=0.1). More interestingly, patientswith poor response (switched to another tyrosine kinase inhibitor because of imatinib failure, or because of disease progression after an initial response) displayed a significantly lower mean imatinib concentration as compared to patients maintained on imatinib (822 ng/mL vs 1099 ng/mL; Student's t-test, p=0.04). Failure or disease progression occurred more often in patients in the lowest quartile of imatinib concentrations compared to patients in the highest quartile (p = 0.02, logrank test). No correlation could be established with other biological or clinical parameter, including complete cytogenic response and majormolecular response. In conclusion: in patients treatedwith imatinib at a fixed daily dose of 400 mg, imatinib plasma concentrations decreased with increasing body weight and were lower in patients switched to another tyrosine kinase inhibitor due to imatinib failure. Systematic determination of imatinib plasma trough levels should be encouraged in such patients. [less ▲]

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See detailBattista Guarino, 'Sermone del cane e del cavallo'. Un texte inconnu à la cour des Este
Valenti, Gianluca ULg; Van den Abeele, Baudouin

in Actes du Colloque international Chevaux, chiens, faucons. L’art vétérinaire antique et médiéval à travers les sources écrites, archéologiques et iconographiques (in press)

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See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULg; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (in press)

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See detailA method for independent component graph analysis of resting-state fMRI. Brain and Behavior 2017, in press
Ribeiro de Paula, Demetrius; Ziegler, Erik; Abeyasinghe, P et al

in Brain and Behavior (in press)

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See detailSostanza e forma nella tradizione del romanzo arturiano in prosa
Leonardi, Lino; Morato, Nicola ULg

E-print/Working paper (in press)

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See detailA fresh look on the limit on ultralight axion-like particles from SN1987A
Payez, Alexandre ULg

in 10th Patras Workshop on Axions, WIMPs and WISPs (in press)

We revisit the limit on very light axion-like particles (ALPs) from the absence of gamma rays coincidental with the neutrino burst from SN1987A. We use updated supernova simulations, modern models for the ... [more ▼]

We revisit the limit on very light axion-like particles (ALPs) from the absence of gamma rays coincidental with the neutrino burst from SN1987A. We use updated supernova simulations, modern models for the magnetic field inside the Galaxy, and a Primakoff cross section which takes into account proton-degeneracy and mass-reduction effects. We finally give an updated exclusion plot for the electromagnetic coupling of sub-eV ALPs, comparing our new bound with other limits as well as with future ALP searches. [less ▲]

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See detailDisorders of consciousness: new advances in neuroimaging techniques
Soddu, Andrea ULg; Bruno, Marie-Aurélie ULg; VANHAUDENHUYSE, Audrey ULg et al

in Zanotti, Bruno (Ed.) Vegetative State (in press)

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See detailAux sources des liturgies indo-iraniennes
Swennen, Philippe ULg; Redard, Céline ULg; Ferrer-Losilla, Joan Josep ULg et al

Book published by Collection Religion (Presses universitaires de l’Université de Liège) (in press)

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See detailFin de siècle/Jahrhundertwende: Eine Tendenzgeschichte
Küpper, Achim ULg

in Roland, Hubert (Ed.) Eine kleine deutsch-französische Literaturgeschichte vom 18. Jahrhundert bis zum Ersten Weltkrieg (in press)

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See detailAnode (electro)catalysts for direct borohydride and ammonia borane fuel cells
Olu, Pierre-Yves ULg; Zadick, Anicet; Job, Nathalie ULg et al

in Electrocatalysts for low temperature fuel cells. Fundamental and recent trends. (in press)

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See detailGellert, Schlegel und die "Lettres de Ninon de Lenclos". Eine Übersetzungsgeschichte
Viehöver, Vera ULg

in Fink, Wolfgang (Ed.) Vernunft und Gefühl. Christian Fürchtegott Gellert und die Umbruchperiode der Aufklärung (1740-1770) (in press)

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See detailL'(ir)responsabilité du pouvoir judiciaire : fondement et mise à l'épreuve de l'immunité judiciaire en droits québécois et belge
Bouhon, Frédéric ULg; Lacroix, Mariève

in Revue de Droit International et de Droit Comparé (in press), 2017/3

Ce long article compare les régimes juridiques belge et québécois sur la question de la responsabilité civile pour les fautes commises par les juges dans l'exercice du pouvoir judiciaire. Bien que les ... [more ▼]

Ce long article compare les régimes juridiques belge et québécois sur la question de la responsabilité civile pour les fautes commises par les juges dans l'exercice du pouvoir judiciaire. Bien que les solutions retenues de part et d’autre de l’Atlantique semblent divergentes a priori – absolutisme de l’immunité du juge au Québec et relativisation de celle-ci en Belgique –, un examen plus approfondi révèle que les incidences pratiques ne sont pas aussi radicalement opposées. Certes, l’État belge peut engager sa responsabilité civile en présence d’une faute du juge, ce qui ne saurait être admis au Québec , mais les modalités de l’action civile que la jurisprudence belge a retenues (spécialement la condition de recevabilité et la notion de faute caractérisée) limitent fortement l’ampleur du contentieux dans ce domaine. Par ailleurs, au Québec, on relève un infléchissement – purement théorique, car aucun cas concret où la responsabilité civile du juge a été retenue n’existe à l’heure actuelle – du principe de l’immunité absolue du juge dans le cadre de sa responsabilité civile personnelle, lorsqu’il agit sans compétence, tout en sachant ne pas avoir compétence d’agir ainsi. [less ▲]

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See detailConfesseur du Prince : un profil singulier ? L’exemple de la cour espagnole de Bruxelles au XVIIe siècle.
Pirlet, Pierre-François ULg

in Les clergés de cour en Europe (fin XVe siècle - XVIIIe siècle). Service religieux et service politique dans les systèmes curiaux - Actes du colloque[Titre à préciser] (in press)

Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son ... [more ▼]

Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son représentant pour les aspects temporels, ce religieux a la faculté unique d'examiner, de conseiller et de juger la spiritualité du premier personnage de l'État. Attaché à la personne du Prince, les relations de cet ecclésiastique avec les autres courtisans ne peuvent être appréhendées au moyen d'une grille de lecture hiérarchisant les rapports sociaux : échappant à l'organisation laïque – mais pas protocolaire – de la cour et ne dépendant pas directement de la Chapelle royale, le confesseur bénéficie d'une autonomie relative. En outre, son pouvoir politique, en partie officiel grâce aux dignités et charges dont ce religieux est pourvu, est avant tout perçu comme une magistrature d'influence à la portée difficilement mesurable. Enfin, les obligations matérielles liées à l'appartenance de ce prélat à un ordre religieux achèvent de distinguer cet ecclésiastique des autres serviteurs princiers. Cette communication visera à distinguer les particularités de la charge de confesseur princier au sein de la société de cour. L'étude portera particulièrement sur la cour de Bruxelles durant la première moitié du xviie siècle. [less ▲]

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See detailBesides Decorum: Notes on Formality
Gillen, Todd Jonathan ULg

in Dorn, Andreas (Ed.) Filtering Decorum – Facing Reality (in press)

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See detailWriting productive traditions: the emergence of the monumental Triumph Scene at Thebes
Gillen, Todd Jonathan ULg

in Gillen, Todd Jonathan (Ed.) (Re)productive Traditions in Ancient Egypt (in press)

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See detailMusikerbiographien und -autobiographien
Viehöver, Vera ULg

in Jahn, Bernhard (Ed.) Handbuch der Musik des Barock, Bd. 5: Musik in den Künsten und Wissenschaften der Barockzeit (in press)

article sur les autobiographies de musiciens dans une encyclopédie en 6 volumes consacrée à la musique à l'âge baroque

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See detailIntroduction: (Re)productive Traditions, Cultural Transmission and Egyptology
Gillen, Todd Jonathan ULg

in Gillen, Todd Jonathan (Ed.) (Re)productive Traditions in Ancient Egypt (in press)

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See detailLandslide risk reduction measures: a review of practices and challenges for the tropics
Maes, Jan; Kervyn, Matthieu; de Hontheim, Astrid et al

in Progress in Physical Geography (in press)

The overall objective of this review is to gain insights into landslide risk reduction measures that are applied or recommended in tropical landslide-prone countries, and the challenges at play. More ... [more ▼]

The overall objective of this review is to gain insights into landslide risk reduction measures that are applied or recommended in tropical landslide-prone countries, and the challenges at play. More specifically, this review aims to (i) presenting an overview of recent studies on landslides and landslide risk reduction in these countries, (ii) exploring the factors controlling the publication output on landslides and landslide risk reduction, (iii) reviewing the various landslide risk reduction measures recommended and implemented, and (iv) identifying the bottlenecks for the implementation of these strategies. A compilation of recommended and implemented landslide risk reduction measures in 99 landslide-prone tropical countries was made, based on an extensive review of scientific literature (382 publications). The documented measures are analysed Corresponding author: Jan Maes, Department of Earth & Environmental Sciences, KU Leuven, Celestijnenlaan 200E 03.256, Heverlee B-3001, Belgium. Email: maes.jan@kuleuven.be Progress in Physical Geography 1–31 ª The Author(s) 2017 Reprints and permission: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/0309133316689344 journals.sagepub.com/home/ppg using a scheme of risk reduction measures that combines classifications of the Hyogo Framework for Action and the SafeLand project. Our literature review shows that the factors influencing the number of publications on landslides and landslide risk reduction per country are (in order of importance) the absolute physical exposure of people to landslides, the population number and the Human Development Index of a country. The ratio of publications on landslide risk reduction versus publications on landslides for landslide-prone tropical countries does not vary much between these countries (average: 0.28). A significant fraction (0.30) of all known landslide hazard reduction measures are neither implemented nor recommended according to our review. The most recommended landslide risk reduction component is ‘risk management and vulnerability reduction’ (0.38). However, the most implemented component is ‘risk assessment’ (0.57). Overall, the ratio of implemented versus recommended landslide risk reduction measures in the tropics is low (<0.50) for most landslide risk reduction components, except for ‘risk assessment’ (3.01). The most cited bottlenecks for implementing landslide risk reduction measures are scientific (0.30) and political (0.29) in nature. [less ▲]

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