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See detailOn-demand continuous flow production of pharmaceuticals in a compact, reconfigurable system
Adamo, Andrea; Beingessner, Rachel L.; Behnam, Mohsen et al

in Science (2016), 352

Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a ... [more ▼]

Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation. [less ▲]

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See detailMaximum Entropy Kernels for System Identification
Carli, Francesca Paola ULg; Chen, Tianshi; Ljung, Lennart

in IEEE Transactions on Automatic Control (2016)

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See detailUne présentation rare de craniosténose associée à un crâne lacunaire
Vaessen, françois; Thimmesch, Mathieu; BORN, Jacques et al

in Revue Médicale de Liège (2016), 71(3), 120-123

A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its ... [more ▼]

A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its physiopathology remains up to now poorly understood; it is mostly associated with neural tube defects. The association of a lacunar skull with a craniosynostosis has rarely been described in the literature. The case of a 9-month-old patient presenting a multisutural craniosynostosis with a lacunar skull is reported in this article. The surgical treatment allowed to remodel the skull and to hope for a spontaneous regression of the lacunae. [less ▲]

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See detailMurray Bail's Eucalyptus: An Australian Fairy-Tale?
Herbillon, Marie ULg

in Collier, Gordon; Davis, Geoff; Delrez, Marc (Eds.) et al The Invention of Legacy: Essays in Memory of Hena Maes-Jelinek (2016)

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See detailPhage therapy against antimicrobial resistance, design of the first clinical study Phagoburn.
Jault, Patrick; Gabard, Jérôme; Leclerc, Thomas et al

in Critical Care (2016), 20(Suppl 2), 109

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See detailInformation behaviour of French-speaking speech–language therapists in Belgium: results of a questionnaire survey
Durieux, Nancy ULg; Pasleau, Françoise ULg; Piazza, Aurélie ULg et al

in Health Information and Libraries Journal (2016), 33

BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study ... [more ▼]

BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study was to explore Belgian French-speaking SLTs’ information behaviour and their awareness of EBP. The collected data allow one to determine how far they have embraced this approach. METHODS: The two Belgian French-speaking SLT professional associations promoted an online questionnaire survey by email. Additionally, clinical supervisors of students were asked to participate. In March 2012, 2068 emails were sent. RESULTS: The participation rate was at least 20% (n = 415). The reported information needs mainly concerned treatment or diagnosis. Most of the time, to attempt to fulfil their information needs, SLTs relied on their own resources (personal experience and libraries) and on colleagues in the workplace. When they searched on the Internet, they preferred to use a general search engine rather than a specialised bibliographic database. Barriers to obtaining scientific information are highlighted. Only 12% of the respondents had already heard about EBP. CONCLUSION: This study provides the first overview of the information behaviour of SLTs working in the French community of Belgium. Several recommendations are suggested for SLTs and librarians. [less ▲]

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See detailUn diplomate allemand en Belgique. Werner von Bargen (1898-1975) dans le débat autour de l’Auswärtiges Amt durant le « Troisième Reich » et dans la jeune République fédérale d’Allemagne
Brüll, Christoph ULg

in Dumoulin, Michel; Lanneau, Catherine (Eds.) La biographie individuelle et collective dans le champ des relations internationales (2016)

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See detailTowards an Australian Philosophy. Constructive Appropriation of Enlightenment Thinking in Murray Bail's The Pages
Herbillon, Marie ULg

in Tunca, Daria; Wilson, Janet (Eds.) Under Construction. Postcolonial Gateways and Walls (2016)

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See detailKinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35.
Marcoccia, Francesca; Bottoni, Carlo; Sabatini, Alessia et al

in Antimicrobial agents and chemotherapy (2016), 60(4), 2366-72

Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized ... [more ▼]

Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized, and their kinetic parameters were compared with those of the NDM-1 wild type. Thekcat,Km, andkcat/Kmvalues calculated for the two mutants were slightly different from those of the wild-type enzyme. Interestingly, thekcat/Kmof NDM-1(I35S)for loracarbef was about 14-fold higher than that of NDM-1. Far-UV circular dichroism (CD) spectra of NDM-1 and NDM-1(I35T)and NDM-1(I35S)enzymes suggest local structural rearrangements in the secondary structure with a marked reduction of alpha-helix content in the mutants. [less ▲]

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See detailHeterogeneous bedrock investigation for a closed-loop geothermal system: A case study
Radioti, Georgia ULg; Delvoie, Simon ULg; Charlier, Robert ULg et al

in Geothermics (2016)

This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The ... [more ▼]

This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The investigated site consists of four boreholes equipped with geothermal pipes on the campus of University of Liege, Belgium. The first approach includes acoustic borehole imaging, gamma-ray logging and cuttings observation and results to a detailed fracture characterisation, rock identification and layer dip angle determination. The second approach consists of measuring the thermal conductivity of cuttings at the laboratory. Study of cuttings thermal conductivity measurements can contribute to bedrock heterogeneity knowledge concerning the transition of one formation to another and the layer dipping. The third approach is based on high-resolution temperature profiles, measured during the hardening of the grouting material and the recovery phase of a Distributed Thermal Response Test. Through this approach a correlation of the temperature profiles to the geological characteristics of the surrounding bedrock is identified. The analysis of this correlation can provide information on fractured zones, alternation of different rock types and layering dipping. This latter approach can be easily applied on closed-loop geothermal systems to characterise the bedrock and investigate its heterogeneity as well as contribute to the their long-term behaviour prediction and to the optimisation of their efficiency. [less ▲]

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See detailA re-examination of O. Cairo JdE 72460 (= O. Cairo SR 1475). Ending the quest for a 19th Dynasty queen’s tomb in the Valley of the Kings
Dorn, Andreas; Polis, Stéphane ULg

in Collombert, Philippe; Lefèvre, Dominique; Polis, Stéphane (Eds.) et al Aere perennius. Mélanges égyptologiques en l'honneur de Pascal Vernus (2016)

In this paper, we offer a new interpretation for O. Cairo JdE 72460. Based on a discussion of the expressions used for measuring distances in the New Kingdom documentation, we explore the various possible ... [more ▼]

In this paper, we offer a new interpretation for O. Cairo JdE 72460. Based on a discussion of the expressions used for measuring distances in the New Kingdom documentation, we explore the various possible translations. We then try to map the abstract relationships between places as well as the related measurements onto actual archeological structures. We come to the conclusion that this ostracon might be linked to work in progress inside KV 5. [less ▲]

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See detailJack-of-all-trades effects drive biodiversity-ecosystem multifunctionality relationships in European forests.
van der Plas, Fons; Manning, Peter; Allan, Eric et al

in Nature communications (2016), 7

There is considerable evidence that biodiversity promotes multiple ecosystem functions (multifunctionality), thus ensuring the delivery of ecosystem services important for human well-being. However, the ... [more ▼]

There is considerable evidence that biodiversity promotes multiple ecosystem functions (multifunctionality), thus ensuring the delivery of ecosystem services important for human well-being. However, the mechanisms underlying this relationship are poorly understood, especially in natural ecosystems. We develop a novel approach to partition biodiversity effects on multifunctionality into three mechanisms and apply this to European forest data. We show that throughout Europe, tree diversity is positively related with multifunctionality when moderate levels of functioning are required, but negatively when very high function levels are desired. For two well-known mechanisms, 'complementarity' and 'selection', we detect only minor effects on multifunctionality. Instead a third, so far overlooked mechanism, the 'jack-of-all-trades' effect, caused by the averaging of individual species effects on function, drives observed patterns. Simulations demonstrate that jack-of-all-trades effects occur whenever species effects on different functions are not perfectly correlated, meaning they may contribute to diversity-multifunctionality relationships in many of the world's ecosystems. [less ▲]

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See detailMonitoring the laccase reaction of vanillin and poplar hydrolysate
Sòti, Valentin; Jacquet, Nicolas ULg; Apers, Sandra et al

in Journal of Chemical Technology & Biotechnology (2016), 91(6), 1914-1922

BACKGROUND: Laccase is an intensively researched enzyme for industrial use. Except for decolorisation measurements, HPLC analysis is the conventional method for monitoring the phenolic removal during ... [more ▼]

BACKGROUND: Laccase is an intensively researched enzyme for industrial use. Except for decolorisation measurements, HPLC analysis is the conventional method for monitoring the phenolic removal during laccase enzyme reaction. This paper reports an investigation of the continuous UV absorbance follow-up of the laccase reaction with steam pretreated poplar hydrolysate. RESULTS: Vanillin was used as a model substrate and lignocellulose xylose rich fraction (XRF) as a biologically complex substrate for laccase detoxification. The reaction was followed by HPLC-UV as well as by UV spectrometric measurements. Results suggest that the reaction can be successfully monitored by measuring the change of UV absorbance at 280 nm, without previous compound separation. In case of XRF experiments the spectrophotometric follow-up is especially useful, as HPLC analysis takes a long time and provides less information than in case of single substrates. The method seems to be suitable for optimization and process control. CONCLUSION: The obtained results can help to construct a fast, easy and straightforward monitoring system for laccase-phenolic substrate reactions. [less ▲]

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See detailL'accompagnement des enfants souffrant d'un trouble du spectre autistique: Les réponses des centres de rééducation ambulatoire
Garcet, Serge ULg; Di Croce, Maria; Moyaerts, Danielle et al

in Dalla Piazza, Serge; Garcet, Marc (Eds.) Entre Physis et Nomos Pour vivre ensemble, nouvelles pratiques. (2016)

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See detailLe scribe et le peintre. À propos d'un scribe qui ne voulait pas être pris pour un peintre
Laboury, Dimitri ULg

in Collombert, Philippe; Lefèvre, Dominique; Polis, Stéphane (Eds.) et al Aere perennius. Mélanges égyptologiques en l'honneur de Pascal Vernus (2016)

Using the famous signature of the scribe Merira in the tomb of the High priest of Nekhbet Setau at Elkab (T. Elkab 4) as a starting point, the article aims at reassessing the status of artists, and more ... [more ▼]

Using the famous signature of the scribe Merira in the tomb of the High priest of Nekhbet Setau at Elkab (T. Elkab 4) as a starting point, the article aims at reassessing the status of artists, and more specifically of painters, in Ancient Egyptian social representation as well as in the discourse of pharaonic scribes [less ▲]

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See detailAn acceleration sensing method based on the mode localization of weakly coupled resonators
Zhang, H.M.; Yuan, W.Z.; Li, B.Y. et al

in Journal of Microelectromechanical Systems (2016), 25(2), 286-296

Abstract—This paper reports an acceleration sensing method based on two weakly coupled resonators (WCRs) using the phenomenon of mode localization. When acceleration acts on the proof masses, differential ... [more ▼]

Abstract—This paper reports an acceleration sensing method based on two weakly coupled resonators (WCRs) using the phenomenon of mode localization. When acceleration acts on the proof masses, differential electrostatic stiffness perturbations will be applied to the WCRs, leading to mode localization, and thus, mode shape changes. Therefore, acceleration can be sensed by measuring the amplitude ratio shift. The proposed mode localization with the differential perturbation method leads to a sensitivity enhancement of a factor of 2 than the common single perturbation method. The theoretical model of the sensitivity, bandwidth, and linearity of the accelerometer is established and verified. The measured relative shift in amplitude ratio (∼312162 ppm/g) is 302 times higher than the shift in resonance frequency (∼1035 ppm/g) within the measurement range of ±1g. The measured resolution based on the amplitude ratio is 0.619 mg and the nonlinearity is ∼3.5% in the open-loop measurement operation. [less ▲]

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See detail. Mass sensor utilising the mode-localisation effect in an electrostatically-coupled MEMS resonator pair fabricated using an SOI process
Wood, Graham; Chun, Zhao; Pu, Suan et al

in Microelectronic Engineering (2016), 159

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode ... [more ▼]

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode-localisation effect. It has been demonstrated that the shift in the amplitude ratio of the coupled-resonators at the in-phase mode frequency, in response to a mass change, is five orders of magnitude greater than the equivalent resonant frequency shift of a single resonator device. The device has been fabricated using a silicon-on-insulator (SOI) based process, which allows for high-yield and stiction-free fabrication. In addition, the design of the resonators has been created to have a larger surface area than previously reported designs, in order to facilitate future biological functionalisation. The mass sensitivity has been compared to current state-of-the-art mode-localised mass sensors and a 5.4 times increase in the amplitude ratio response to a given mass change has been demonstrated for the device in this work. [less ▲]

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See detailLes codices médicaux grecs de petit format en parchemin dans l'Egypte byzantine
Marganne, Marie-Hélène ULg

in Davoli, Paola; Pellé, Natascia (Eds.) Polymatheia. Studi offerti a Mario Capasso (2016)

After an examination of the literary evidence on parchment notebooks containing medical recipes, this paper provides a repertoire of the small-format Greek medical parchment codices from Byzantine Egypt ... [more ▼]

After an examination of the literary evidence on parchment notebooks containing medical recipes, this paper provides a repertoire of the small-format Greek medical parchment codices from Byzantine Egypt. The internal and external charecteristics of these manuscripts are compared, in an effort to gather information on their context of production and use. [less ▲]

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