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See detailPrésentation de cas cliniques résolus ou non résolus
WANG, François-Charles ULg

Scientific conference (2015, February 03)

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See detailEstimation of the Time Interval between the Administration of Heroin and the Sampling of Blood in Chronic Inhalers
DUBOIS, Nathalie ULg; HALLET, Claude ULg; SEIDEL, Laurence ULg et al

in Journal of Analytical Toxicology (2015)

To develop a model for estimating the time delay between last heroin consumption and blood sampling in chronic drug users. Eleven patients, all heroin inhalers undergoing detoxification, were included in ... [more ▼]

To develop a model for estimating the time delay between last heroin consumption and blood sampling in chronic drug users. Eleven patients, all heroin inhalers undergoing detoxification, were included in the study. Several plasma samples were collected during the detoxification procedure and analyzed for the heroin metabolites 6-acetylmorphine (6AM), morphine (MOR), morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G), according to a UHPLC/MSMS method. The general linear mixed model was applied to time-related concentrations and a pragmatic four-step delay estimation approach was proposed based on the simultaneous presence of metabolites in plasma. Validation of the model was carried out using the jackknife technique on the 11 patients, and on a group of 7 test patients. Quadratic equations were derived for all metabolites except 6AM. The interval delay estimation was 2–4 days when only M3G present in plasma, 1–2 days when M6G and M3G were both present, 0–1 day when MOR, M6G and M3G were present and <2 h for all metabolites present. The ‘jackknife’ correlation between declared and actual estimated delays was 0.90. The overall precision of the delay estimates was 8–9 h. The delay between last heroin consumption and blood sampling in chronic drug users can be satisfactorily predicted from plasma heroin metabolites. [less ▲]

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See detailContribution to the Macrophytic Typology of Belgian Reference Watercourses
Galoux, Daniel; Cherot, Frédéric; Rosillon, Francis ULg et al

in Advances in Botany (2015), Volume 2015, Article ID 651369

The objective of the study is to create a typology of macrophytes for the reference watercourses of the Meuse River catchment ... [more ▼]

The objective of the study is to create a typology of macrophytes for the reference watercourses of the Meuse River catchment basininWalloniaasasteptowardstheimplementationoftheEuropeanWaterFrameworkDirective.The50sitesstudiedarethe objectofaphysicochemicalandenvironmentalcharacterizationfollowedbyafloristicsurvey(phanerogams,mosses,liverworts, andmacroalgae).Sixclustersofwatercourseswiththeircharacteristicspeciesarehighlightedbytwo-wayclusteringandindicator species. The abundance of phanerogams in some watercourses of the Arden region is not only linked to light intensity but also dependsonthedegreeofslopeandthenatureofthegeologicalsubstrate [less ▲]

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See detailThe non-convex shape of (234) Barbara, the first Barbarian
Tanga, Paolo; Carry, B.; Colas, F. et al

in Monthly Notices of the Royal Astronomical Society (2015)

Asteroid (234) Barbara is the prototype of a category of asteroids that has been shown to be extremely rich in refractory inclusions, the oldest material ever found in the Solar System. It exhibits ... [more ▼]

Asteroid (234) Barbara is the prototype of a category of asteroids that has been shown to be extremely rich in refractory inclusions, the oldest material ever found in the Solar System. It exhibits several peculiar features, most notably its polarimetric behavior. In recent years other objects sharing the same property (collectively known as ”Barbarians”) have been discovered. Interferometric observations in the mid-infrared with the ESO VLTI suggested that (234) Barbara might have a bi-lobated shape or even a large companion satellite. We use a large set of 57 optical lightcurves acquired between 1979 and 2014, together with the timings of two stellar occultations in 2009, to determine the rotation period, spin-vector coordinates, and 3-D shape of (234) Barbara, using two different shape reconstruction algorithms. By using the lightcurves combined to the results obtained from stellar occultations, we are able to show that the shape of (234) Barbara exhibits large concave areas. Possible links of the shape to the polarimetric properties and the object evolution are discussed. We also show that VLTI data can be modeled without the presence of a satellite [less ▲]

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See detailMagnetic shielding of an inhomogenous magnetic field source by a bulk superconducting tube
Hogan, Kevin ULg; Fagnard, Jean-François ULg; Wera, Laurent ULg et al

in Superconductor Science and Technology (2015), 28(3), 035011

Bulk type-II irreversible superconductors can act as excellent passive magnetic shields, with a strong attenuation of low frequency magnetic fields. Up to now, the performances of superconducting magnetic ... [more ▼]

Bulk type-II irreversible superconductors can act as excellent passive magnetic shields, with a strong attenuation of low frequency magnetic fields. Up to now, the performances of superconducting magnetic shields have mainly been studied in a homogenous magnetic field, considering only immunity problems, i.e. when the field is applied outside the tube and the inner field should ideally be zero. In this paper, we aim to investigate experimentally and numerically the magnetic response of a high-Tc bulk superconducting hollow cylinder at 77 K in an emission problem, i.e. when subjected to the non-uniform magnetic field generated by a source coil placed inside the tube. A bespoke 3-D mapping system coupled with a 3-axis Hall probe is used to measure the magnetic flux density distribution outside the superconducting magnetic shield. A finite element model is developed to understand how the magnetic field penetrates into the superconductor and how the induced superconducting shielding currents flow inside the shield in the case where the emitting coil is placed coaxially inside the tube. The finite element modelling is found to be in excellent agreement with the experimental data. Results show that a concentration of the magnetic flux lines occurs between the emitting coil and the superconducting screen. This effect is observed both with the modelling and the experiment. In the case of a long tube, we show that the main features of the field penetration in the superconducting walls can be reproduced with a simple analytical 1D model. This model is used to estimate the maximum flux density of the emitting coil that can be shielded by the superconductor. [less ▲]

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See detailDifferential Performance between Two Timber Species in Forest Logging Gaps and in Plantations in Central Africa
Fayolle, Adeline ULg; Ouedraogo, Dakis-Yaoba ULg; Ligot, Gauthier ULg et al

in Forests (2015), 6(2), 380-394

To develop silvicultural guidelines for high-value timber species of Central African moist forests, we assessed the performance of the pioneer Milicia excelsa (iroko, Moraceae), and of the non-pioneer ... [more ▼]

To develop silvicultural guidelines for high-value timber species of Central African moist forests, we assessed the performance of the pioneer Milicia excelsa (iroko, Moraceae), and of the non-pioneer light demander Pericopsis elata (assamela, Fabaceae) in logging gaps and in plantations in highly degraded areas in south-eastern Cameroon. The survival and size of each seedling was regularly monitored in the silvicultural experiments. Differences in performance and allometry were tested between species in logging gaps and in plantations. The two species performance in logging gaps was significantly different from plantations and concurred with the expectations of the performance trade-off hypothesis but not with the expectations of species light requirements. The pioneer M. excelsa survived significantly better in logging gaps while the non-pioneer P. elata grew significantly faster in plantations. The high mortality and slow growth of M. excelsa in plantations is surprising for a pioneer species but could be explained by herbivory (attacks from a gall-making psyllid). Identifying high-value native timber species (i) with good performance in plantations such as P. elata is of importance to restore degraded areas; and (ii) with good performance in logging gaps such as M. excelsa is of importance to maintain timber resources and biodiversity in production forests. [less ▲]

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See detailMBD du laboratoire à la clinique
CAVALIER, Etienne ULg

Conference (2015, February 02)

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See detailPrésentation de "The Lady from Shangaï" d'Orson Welles
Tomasovic, Dick ULg

Conference given outside the academic context (2015)

Evocation du style filmique d'Orson Welles à travers son film "La Dame de Shangaï" (1948).

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See detailNew spectroscopic and polarimetric observations of the A0 supergiant HD 92207
Hubrig, S.; Kholtygin, A. F.; Schöller, M. et al

in Astronomische Nachrichten (2015), 336

Our recent search for the presence of a magnetic field in the bright early A-type supergiant HD 92207 using FORS 2 in spectropolarimetric mode revealed the presence of a longitudinal magnetic field of the ... [more ▼]

Our recent search for the presence of a magnetic field in the bright early A-type supergiant HD 92207 using FORS 2 in spectropolarimetric mode revealed the presence of a longitudinal magnetic field of the order of a few hundred Gauss. However, the definite confirmation of the magnetic nature of this object remained pending due to the detection of short-term spectral variability probably affecting the position of line profiles in left- and right-hand polarized spectra. We present new magnetic field measurements of HD 92207 obtained on three different epochs in 2013 and 2014 using FORS 2 in spectropolarimetric mode. A 3σ detection of the mean longitudinal magnetic field using the entire spectrum, <B_z>_all=104±34 G, was achieved in observations obtained in 2014 January. At this epoch, the position of the spectral lines appeared stable. Our analysis of spectral line shapes recorded in opposite circularly polarized light, i.e. in light with opposite sense of rotation, reveals that line profiles in the light polarized in a certain direction appear slightly split. The mechanism causing such a behaviour in the circularly polarized light is currently unknown. Trying to settle the issue of short-term variability, we searched for changes in the spectral line profiles on a time scale of 8-10 min using HARPS polarimetric spectra and on a time scale of 3-4 min using time series obtained with the CORALIE spectrograph. No significant variability was detected on these time scales during the epochs studied. Based on observations collected with the CORALIE echelle spectrograph mounted on the 1.2-m Swiss telescope at La Silla Observatory, data obtained at the European Southern Observatory (ESO Prg. 092.D-0209(A), and data obtained from the ESO Science Archive Facility under request MSCHOELLER 102067). [less ▲]

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See detailSelf-assembly of a triblock terpolymer mediated by hydrogen-bonded complexes
Guerlain, Claire; Piogé, Sandie; Detrembleur, Christophe ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2015), 53(3), 459-467

A poly(methyl methacrylate)-block-poly(4-vinylpyridine)-block-polystyrene (PMMA-b-P4VP-b-PS) triblock terpolymer is synthesized by ATRP to study its self-assembly with PAA in organic solvents. The self ... [more ▼]

A poly(methyl methacrylate)-block-poly(4-vinylpyridine)-block-polystyrene (PMMA-b-P4VP-b-PS) triblock terpolymer is synthesized by ATRP to study its self-assembly with PAA in organic solvents. The self-assembly behavior of this system is compared with the one of a mixture of two diblocks, namely polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) and poly(methyl methacrylate)-block-poly(methacrylic acid) (PMMA-b-PMAA). For both systems, formation of hydrogen-bonded complexes between the P4VP and PMAA or PAA blocks occurs. These complexes become insoluble in the solvent used and micelles with a P4VP/P(M)AA complexes core surrounded by PS and PMMA coronal chains are obtained in both cases. These micelles are analyzed by DLS and TEM. Spherical micelles are formed for both systems but the hydrodynamic radii obtained for the two types of micelles are different. Indeed, the micelles formed by the PMMA-b-P4VP-b-PS + PAA system are smaller than those observed for the PS-b-P4VP + PMMA-b-PMAA system. Finally, the effect of the molar ratio of the P4VP/PMAA complexing blocks is investigated. [less ▲]

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See detailEconomics of a decision-support system for managing the main fungal diseases of winter wheat in the Grand-Duchy of Luxembourg
El Jarroudi, Moussa ULg; Kouadio, Louis; Beyer, Marco et al

in Field Crops Research (2015), 172(2), 32-41

We evaluated the cost effectiveness of a decision-support system (DSS) developed for assessing in real time the risk of progression of the main fungal diseases (i.e., Septoria leaf blotch, powdery mildew ... [more ▼]

We evaluated the cost effectiveness of a decision-support system (DSS) developed for assessing in real time the risk of progression of the main fungal diseases (i.e., Septoria leaf blotch, powdery mildew, leaf rusts and Fusarium head blight) of winter wheat in the Grand-Duchy of Luxembourg (GDL). The study was conducted in replicated field experiments located in four agricultural locations (representative of the main agro-ecological regions of the country) over a 10-year period (2003-2012). Three fungicide spray strategies were compared: a single DSS-based system and two commonly used spray practices in the GDL, a double- (2T)- and a triple- spray (3T) spray treatment; there was also a non-treated control. In years with a high disease pressure, the DSS-based recommendation resulted in protection of the three upper leaves comparable to that achieved with the 2T and 3T treatments, with significant grain yield increases (P > 0.05) compared to the control (a 4 to 42% increase, depending on the site and year). Overall, the financial gain in treated plots compared with the control ranged from 3 to 16% at the study sites. Furthermore, in seasons when dry weather conditions precluded epidemic development, no the DSS-basedDSS recommended no fungicide spray was recommended, reducing use of fungicide, and thus saving the cost of the product. The gain in yield for the 2T and 3T plots (compared with control) did not necessarily result in a financial gain during the duration of the experiment. This study demonstrates the potential advantages and profitability of using a DSS -based approach for disease management. [less ▲]

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See detailA comparison between visual estimates and image analysis measurements to determine Septoria leaf blotch severity in winter wheat
El Jarroudi, Moussa ULg; Kouadio, Louis; Mackels, Christophe et al

in Plant Pathology (2015)

Methods to estimate disease severity vary in accuracy, reliability, ease of use and cost. Severity of Septoria leaf blotch (SLB, caused by Zymoseptoria graminicola) was estimated by four raters and by ... [more ▼]

Methods to estimate disease severity vary in accuracy, reliability, ease of use and cost. Severity of Septoria leaf blotch (SLB, caused by Zymoseptoria graminicola) was estimated by four raters and by image analysis (assumed actual values) on individual leaves of winter wheat in order to explore accuracy and reliability of estimates, and to ascertain whether there were any general characteristics of error. Specifically, (i) we determined the accuracy and reliability of visual assessments of SLB over the full range of severity from 0 to 100%, and we investigated (ii) whether certain 10% ranges in actual disease severity between 0 and 100% were more prone to estimation error compared with others, and (iii) whether leaf position affected accuracy within those ranges. Lin's concordance correlation analysis of all severities (0 to 100%) demonstrated that all raters had estimates close to the actual values (agreement: ρc = 0.92-0.99). However, agreement between actual SLB severities and estimates by raters was less good when compared over short 10% subdivisions within the 0-100% range (ρc = -0.12 to 0.99). Despite common rater imprecision at estimating low and high SLB severities, individual raters differed considerably in their accuracy over the short 10% subdivisions. There was no effect of leaf position on accuracy or precision of severity estimate on separate leaves (L1-L3). Pursuing efforts in understanding error in disease estimation should aid in improving the accuracy of assessments, making visual estimates of disease severity more useful for research and applied purposes. [less ▲]

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See detailThe summer 2012 Greenland heat wave: in situ and remote sensing observations of water vapour isotopic composition during an atmospheric river event†
Bonne, JL; Steen-Larsen, HC; Risi, C. et al

in Journal of Geophysical Research. Atmospheres (2015)

During July 7-12, 2012, extreme moist and warm conditions occurred over Greenland, leading to widespread surface melt. To investigate the physical processes during the atmospheric moisture transport of ... [more ▼]

During July 7-12, 2012, extreme moist and warm conditions occurred over Greenland, leading to widespread surface melt. To investigate the physical processes during the atmospheric moisture transport of this event, we study the water vapour isotopic composition using surface in situ observations in Bermuda Island, South Greenland coast (Ivittuut) and Northwest Greenland ice sheet (NEEM), as well as remote sensing observations (IASI instrument on-board MetOp-A), depicting propagation of similar surface and mid-tropospheric humidity and δD signals. Simulations using Lagrangian moisture source diagnostic and water tagging in a regional model showed that Greenland was affected by an atmospheric river transporting moisture from the western subtropical North Atlantic Ocean, which is coherent with observations of snow pit impurities deposited at NEEM. At Ivittuut, surface air temperature, humidity and δD increases are observed. At NEEM, similar temperature increase is associated with a large and long-lasting ~100 δD enrichment and ~15 deuterium excess decrease, thereby reaching Ivittuut level. We assess the simulation of this event in two isotope-enabled atmospheric general circulation models (LMDz-iso and ECHAM5-wiso). LMDz-iso correctly captures the timing of propagation for this event identified in IASI data but depict too gradual variations when compared to surface data. Both models reproduce the surface meteorological and isotopic values during the event but underestimate the background deuterium excess at NEEM. Cloud liquid water content parametrization in LMDz-iso poorly impacts the vapour isotopic composition. Our data demonstrate that during this atmospheric river event the deuterium excess signal is conserved from the moisture source to Northwest Greenland. [less ▲]

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See detailModelling, Design, and Optimisation of Net-Zero Energy Buildings
Attia, Shady ULg; Hamdy, Mohamed; Carlucci, Salvatore et al

in Athienitis, Andreas; O’Brien (Eds.) Building Performance Optimisation of Net Zero-Energy Buildings (2015)

Automated mathematical building performance optimisation (BPO) paired with building performance simulation (BPS) is a promising solution to use as a means to evaluating many different design options and ... [more ▼]

Automated mathematical building performance optimisation (BPO) paired with building performance simulation (BPS) is a promising solution to use as a means to evaluating many different design options and obtain the optimal or near optimal for a given objective or combination of objectives (e.g., lowest life-cycle cost, lowest capital cost, highest thermal comfort) while achieving fixed objectives (e.g., net zero-energy) (Wetter 2001; Charron and Athienitis 2006; Christensen and Anderson 2006; Brown, Glicksman et al. 2010; Bucking, Athienitis et al. 2010 ). Traditionally, buildings are designed based on heuristic rules separating the design process into early and late design stages with two different discipline specialisations mainly architecture and engineering. By employing optimisation techniques building designers can cross those barriers between disciplines and address the design process as one continuous stage. Optimisation can allow that by addressing all building design parameters, as shown in Figure 4.1, in a holistic approach allowing the optimisation of geometry, envelope, comfort, systems and renewable. The previously often ill defined design problem would under this perspective be defined as a problem with explicit multi-objective criteria. This will push fully integrated net zero-energy building (Net-ZEB) designs where the builder designers can act to influence the direction of the optimisation. Despite optimisation’s potential in Net-ZEB buildings, it remains largely a research tool and has yet to emerge in common industry practice. As this section reports, major obstacles to BPO in industry include lack of appropriate tools, lack of resources (time, expertise), and the requirement that the problem be very well defined (e.g., constraints, objective function, finite list of design options). The objective of this section is to document the current state-of-the-art and future research in terms of Net-ZEB optimisation tools in practice and its use for design and operation of buildings for energy, comfort and cost optimisation. [less ▲]

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See detailTRAPPIST monitoring of comet C/2012 F6 (Lemmon)
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2015), 574

We report the results of the long-term narrowband photometry and imaging monitoring of comet C/2012 F6 (Lemmon) with the robotic TRAPPIST telescope (La Silla Observatory). Observations covered 52 nights ... [more ▼]

We report the results of the long-term narrowband photometry and imaging monitoring of comet C/2012 F6 (Lemmon) with the robotic TRAPPIST telescope (La Silla Observatory). Observations covered 52 nights pre- and post-perihelion between December 11, 2012, and June 11, 2013 (perihelion: 24 March, 2013). We followed the evolution of the OH, NH, CN, C[SUB]3[/SUB], and C[SUB]2[/SUB] production rates computed with the Haser model as well as the evolution of the A(θ)fρ parameter as a proxy for the dust production. All five gas species display similar slopes for the heliocentric dependence. An asymmetry about perihelion is observed, the rate of brightening being steeper than the rate of fading. The chemical composition of the comet's coma changes slightly along the orbit: the relative abundance of C[SUB]2[/SUB] to CN increases with the heliocentric distance (r) below -1.4 au and decreases with r beyond 1.4 au while the C[SUB]3[/SUB]-to-CN ratio is constant during our observations. The behavior of the dust is different from that of the gas, the slope of the heliocentric dependence becoming steeper in early February, correlated to a change in the visual lightcurve slope. However, the dust color does not vary during the observations. The application of several enhancement techniques on the images revealed structures in the CN, C[SUB]3[/SUB], and C[SUB]2[/SUB] images. These features imply the existence of one or several active zone(s) on the comet nucleus. The shape of the structures is similar in these three filters and changes from a roughly hourglass shape in December and January to a corkscrew shape in February and March. The structures in the continuum filters (sampling the dust) are not correlated to those observed for the gas. During several full nights in February, we observed changes in the CN and C[SUB]2[/SUB] structures that repeated periodically because of the nucleus rotation, our derived rotational period being of 9.52 ± 0.05 h. Full Tables 2, 4, 6 are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/574/A38">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/574/A38</A> [less ▲]

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See detailA Review of Pharmaceutical Extrusion: Critical Process Parameters and Scaling-up
Thiry, Justine ULg; Krier, Fabrice ULg; Evrard, Brigitte ULg

in International Journal of Pharmaceutics (2015), 479(1), 227-240

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However ... [more ▼]

Hot melt extrusion has been a widely used process in the pharmaceutical area for three decades. In this field, it is important to optimize the formulation in order to meet specific requirements. However, the process parameters of the extruder should be as much investigated as the formulation since they have a major impact on the final product characteristics. Moreover, a design space should be defined in order to obtain the expected product within the defined limits. This gives some freedom to operate as long as the processing parameters stay within the limits of the design space. Those limits can be investigated by varying randomly the process parameters but it is recommended to use design of experiments. An examination of the literature is reported in this review to summarize the impact of the variation of the process parameters on the final product properties. Indeed, the homogeneity of the mixing, the state of the drug (crystalline or amorphous), the dissolution rate, the residence time, can be influenced by variations in the process parameters. In particular, the impact of the following process parameters: temperature, screw design, screw speed and feeding, on the final product, has been reviewed. [less ▲]

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See detailPour une culture en réseaux diversifiée : Appliquer la Convention sur la protection et la promotion de la diversité des expressions culturelles (CDEC) à l’ère du numérique
Vlassis, Antonios ULg

Report (2015)

Le numérique, Internet tout particulièrement, transforme fondamentalement l’économie de la création dans toutes ses dimensions, artistiques, sociétales et économiques. Ces transformations sont ... [more ▼]

Le numérique, Internet tout particulièrement, transforme fondamentalement l’économie de la création dans toutes ses dimensions, artistiques, sociétales et économiques. Ces transformations sont accompagnées d’opportunités et de risques pour la diversité des expressions culturelles, que ce soit pour profiter pleinement des opportunités offertes par le numérique ou encore pour faire face aux défis qu’il pose aux acteurs du terrain, aux responsables des politiques publiques ou de la coopération internationale dans le domaine de la culture. L’application de la CDEC dans le contexte du numérique peut permettre aux États Parties de trouver des réponses et des modes d’actions (mesures, politiques ou autres), aux niveaux national et international, susceptibles de créer l’environnement institutionnel requis pour que cette révolution numérique soit un véritable moteur d’innovations et de diversité des expressions culturelles. [less ▲]

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See detailExploring new dimensions in cadaveric decomposition odour analysis
Stefanuto, Pierre-Hugues ULg; Perrault, Katelynn; Lloyd, Rebecca et al

in Analytical Methods (2015), 7

This study demonstrates the first documented use of comprehensive two-dimensional gas chromatography – high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS) for volatile organic compound ... [more ▼]

This study demonstrates the first documented use of comprehensive two-dimensional gas chromatography – high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS) for volatile organic compound analysis in the forensic sciences. High-resolution mass spectral data provided higher confidence in analyte identification. GC×GC-HRTOFMS will be valuable for future studies of decomposition odour and other complex volatile matrices. [less ▲]

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See detailLes PPP comme nouveau mode de régulation du marché de l'accompagnement des demandeurs d'emploi. A chaque modèle de partenariat son type de stratégie
Remy, Céline ULg

in Cahiers Loyola (2015, February), 1

Cette communication vise à montrer en quoi les partenariats publics-privés (PPP) constituent désormais un nouveau mode de régulation du marché de l’accompagnement des demandeurs d’emploi. Les services ... [more ▼]

Cette communication vise à montrer en quoi les partenariats publics-privés (PPP) constituent désormais un nouveau mode de régulation du marché de l’accompagnement des demandeurs d’emploi. Les services publics de l’emploi (SPE) doivent établir des PPP avec des prestataires de service pour la mise en place de formation à destination des demandeurs d’emploi. La réalisation de trois études de cas au sein des SPE, dont deux en Belgique et une en Suisse, nous permet de mettre en évidence une forte influence du modèle de gestion du PPP sur la collaboration entre les parties-prenantes mais aussi sur les stratégies développées par les prestataires pour surmonter les problèmes liés à la collaboration avec l’Office de l’Emploi et à la mise en place de la prestation de service. [less ▲]

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See detailEffects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis
Preud'Homme, Valérie; Milla, Sylvain; Gillardin, Virginie et al

in Chemosphere (2015), 120(2), 357-364

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of ... [more ▼]

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of its wide use and known effects, particularly neurotoxic, on a variety of organisms. However, the effect of endosulfan was not yet evaluated on amphibians at levels encompassing simultaneously brain neurotransmitters and behavioural endpoints. In this context, tadpoles of the African clawed frog Xenopus laevis were submitted to four treatments during 27 d: one control, one ethanol control, and two low environmental concentrations of endosulfan (0.1 and 1 μg L−1). Endosulfan induced a significant increase of brain serotonin level at both concentrations and a significant increase of brain dopamine and GABA levels at the lower exposure but acetylcholinesterase activity was not modified by the treatment. The gene coding for the GABA transporter 1 was up-regulated in endosulfan contaminated tadpoles while the expression of other genes coding for the neurotransmitter receptors or for the enzymes involved in their metabolic pathways was not significantly modified by endosulfan exposure. Endosulfan also affected foraging, and locomotion in links with the results of the physiological assays, but no effects were seen on growth. These results show that low environmental concentrations of endosulfan can induce adverse responses in X. laevis tadpoles. At a broader perspective, this suggests that more research using and linking multiple markers should be used to understand the complex mode of action of pollutants. [less ▲]

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