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See detailModelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study.
FRIPPIAT, Frédéric ULg; Musuamba, FT; Seidel, Laurence ULg et al

in Journal of Antimicrobial Chemotherapy (2015)

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in ... [more ▼]

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25 to extended infusion (EI; over 3 h) groups. Based on plasma and epithelial lining fluid (ELF) concentrations determined at steady-state, pharmacokinetic modelling and Monte Carlo simulations were undertaken to assess the probability of attaining drug concentrations above the MIC for 40%-100% of the time between doses (%T > 1-fold and 4-fold MIC), for 1 or 2 g administered by either method. RESULTS: Penetration ratio, measured by the ELF/plasma ratio of AUCs, was statistically higher in the EI group than in the II group (mean ± SEM: 0.29 ± 0.030 versus 0.20 ± 0.033, P = 0.047). Considering a maximum susceptibility breakpoint of 2 mg/L, all dosages and modes of infusions achieved 40%-100% T > 1-fold MIC in plasma, but none did so in ELF, and only the 2 g dose over EI achieved 40%-100% T > 4-fold MIC in plasma. CONCLUSIONS: The optimum regimen to treat severe nosocomial pneumonia was 2 g of meropenem infused over 3 h every 8 h. This regimen achieved the highest pharmacodynamic targets both in plasma and in ELF. [less ▲]

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See detailTransnational Health Insurance Schemes: A New Avenue for Congolese Immigrants in Belgium to Care for Their Relatives’ Health from Abroad?
Lafleur, Jean-Michel ULg; Lizin, Olivier

E-print/Working paper (2015)

What can immigrants do for non-migrant relatives in their home country who need healthcare they cannot afford? To answer this question, we first examine four existing methods that can be found in the ... [more ▼]

What can immigrants do for non-migrant relatives in their home country who need healthcare they cannot afford? To answer this question, we first examine four existing methods that can be found in the existing literature: mobility, remittances, workers’ health insurance and diasporic health insurance. In the second part of the paper, we discuss an innovative strategy called “transnational health insurance” (THI). These insurance schemes are set up by immigrants in cooperation with a multitude of actors including health insurance companies in destination countries and healthcare providers in countries origin. THIs offer health coverage to non-migrant relatives in the home country based on a premium paid directly by immigrants to the insurance company in their country of residence. Analyzing the creation and implementation of Belgian-Congolese THIs, we discuss the strengths and weaknesses of these schemes in responding to the needs of both immigrants and their non-migrant relatives. The article concludes with a discussion on the specificities of THIs as hybrid forms of remittances. [less ▲]

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See detailLa France et le Congo ex-belge (1961-1965). Intérêts et influences en mutation
Genin, Vincent ULg

in Revue Belge de Philologie et d'Histoire (2015), 91(2013/4), 1057-1110

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective ... [more ▼]

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective. Ostracized by the United Nations in the summer of 1960 in the context of the Congolese crisis, Belgium has, however, been able to count on the support of France, itself immobilized by the Algerian case. Based on unpublished archives, it seems instructive to study the evolution of the Franco-Belgian relations, in terms of Central African Affairs from 1961 to 1965. France, the overseas influence policy is a fundamental factor, she will devote as much energy to develop and defend its interests in Congo former Belgian (on which she claimed in Brussels its preemptive right, dating back to 1884, spring 1960) as former territories of the French Community? What are the forms, the protagonists and channels (formal and informal) of this influence; how is she fits the postcolonial context and she has an impact on Franco-Belgian relations ? [less ▲]

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See detailFive-spring model for complete shear behaviour of deep beams
Mihaylov, Boyan ULg

in Structural Concrete (2015), 16(1), 71-83

This paper presents a five-spring model capable of predicting the complete pre- and post-peak shear behaviour of deep beams. The model stems from a two-parameter kinematic theory (2PKT) for the shear ... [more ▼]

This paper presents a five-spring model capable of predicting the complete pre- and post-peak shear behaviour of deep beams. The model stems from a two-parameter kinematic theory (2PKT) for the shear strength and displacement capacity of deep beams under single curvature. Four of the springs of the model represent the shear resistance mechanisms of the beam, while the fifth spring models the flexural behaviour. The model predicts not only the load–displacement response, but also the deformation patterns of the beam and how these patterns change with increasing load. Validation studies are performed by using 28 tests from the literature, showing excellent results. The model is used to interpret the tests and to draw conclusions about the behaviour of deep beams. It is shown that shear strength variations of up to 60 % between nominally identical specimens can be caused by variations in the path of the critical shear cracks. It is also demonstrated that loss of bond of large reinforcing bars increases the shear capacity of deep beams. Finally, the five-spring model is shown to predict the post-peak shear behaviour effectively, which is important for the analysis of structures under extreme loading. [less ▲]

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See detailDegree of phosphorus saturation in agricultural loamy soils with a near-neutral pH
Renneson, Malorie ULg; Vandenberghe, Christophe ULg; Dufey, Joseph et al

in European Journal of Soil Science (2015), 66

The degree of phosphorus saturation (DPS) represents the ratio of sorbed phosphorus (P) to the P sorption capacity (PSC) of soils. In some countries, DPS is used to evaluate the risk of P loss and surface ... [more ▼]

The degree of phosphorus saturation (DPS) represents the ratio of sorbed phosphorus (P) to the P sorption capacity (PSC) of soils. In some countries, DPS is used to evaluate the risk of P loss and surface water eutrophication. This study investigated DPS measurement and prediction in neutral loamy soils fromWallonia, Belgium. A total of 57 agricultural topsoil samples subject to diverse P management were evaluated. No satisfactory relationship could be found between PSC determined by a one-point short-term isotherm in the laboratory and the sum of aluminium and iron extracted by oxalate (Alox +Feox). The equation PSC=a Alox +b pHw appeared to be more appropriate for estimating PSC in the soils studied. These soils had a near-neutral pH, and P fixation processes linked to the presence of calcium ions or carbonates were important. Comparisons of DPS with soil-test P and water-extracted P suggested that DPS could be a useful agronomic and/or environmental indicator. Our results also showed that DPS values between 20 and 30% corresponded to the agronomic optimum of soil P content. Consequently, DPS may be used as an indicator of P status in neutral soils, provided that the PSC assessment is adapted to the local soil characteristics. [less ▲]

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See detailHabitat use by white-thighed colobus in the Kikélé sacred forest: ativity budget, feeding ecology and selection of sleeping trees
Djègo-Djossou, Sylvie; Koné, I; Fandohan, A.B. et al

in Primate conservation (2015), 29

Abstract: Understanding habitat preference and use is an important aspect of primate ecology, and is essential for setting conservation strategies. This study examined the activity budget, feeding ecology ... [more ▼]

Abstract: Understanding habitat preference and use is an important aspect of primate ecology, and is essential for setting conservation strategies. This study examined the activity budget, feeding ecology and selection of sleeping trees of a population of white-thighed colobus (Colobus vellerosus). A group of 18 was followed during 72 days over a full annual cycle in the Kikélé Sacred Forest of the Bassila administrative region in central Benin (West Africa). Activity budget and diet were determined using scan sampling. The structure of the habitat and the physical characteristics of sleeping trees were determined using plot surveys. Resting, feeding, moving, social interactions and other activities accounted for 56.6%, 26.3%, 13.0%, 3.3%, and 0.7% of the activity budget, respectively. The group spent more time feeding and less time moving in the dry season compared to the rainy season. The diet was composed of 35 plant species belonging to 16 families, with items including leaves, fruits, seeds, buds, bark, flowers, gum, and inflorescences. Only three tree species were used as sleeping trees: Celtis integrifolia, Cola cordifolia, and Holoptelea grandis. Our findings suggest that the monkeys prefer tall (22.53 ± SD 3.76 m) and large-trunked (112.07 ± SD 14.23 cm) sleeping trees. The results of this study can be used for sound management of the white-thighed colobus in the study area and elsewhere. [less ▲]

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See detailEvaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture: le cas de La Bruyère
Thiry, Aline ULg; Halin, Jordan ULg; Italiano, Patrick ULg et al

Report (2015)

This report presents a study case research done in the "Evaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture" in Wallonia-Brussel Federation.

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See detailEvaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture: le cas de Berchem Sainte-Agathe
Halin, Jordan ULg; Thiry, Aline ULg; Fallon, Catherine ULg et al

Report (2015)

This report presents a study case research done in the "Evaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture" in Wallonia-Brussel Federation.

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See detailMobilisations du droit, dans ou hors des tribunaux? La lutte contre les discriminations au travail en Suède et en Belgique
Lejeune, Aude ULg

in Baudot, Pierre-Yves; Revillard, Anne (Eds.) L’Etat des droits. Politique des droits et pratiques des institutions (2015)

Legal mobilization, inside or outside the courtroom ? The case of workplace discrimination in Sweden and Belgium -- In the field of non-discrimination, European dirctives and transnational networks for ... [more ▼]

Legal mobilization, inside or outside the courtroom ? The case of workplace discrimination in Sweden and Belgium -- In the field of non-discrimination, European dirctives and transnational networks for equality suggest common frames in order to uniformize legal practices among member states. Among others, they require each state to guarantee access to justice for plaintiffs who have experienced discrimination and for organizations which promote their rights. The implementation of these common norms and frames varies across the countries. From an empirical investigation on workplace discrimination, this chapter examines how equality agencies mobilize, or do not mobilize, the labor court in two countries, Sweden and Belgium. The author shows that the role of equality agencies in labor issues in each national setting influences their choices and opportunities to mobilize the law, inside and outside the courtroom, to fight workplace discrimination. In return, their activity also creates new legal opportunities to promote workers’ rights. [less ▲]

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See detailEvaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture: le cas de Hotton
Halin, Jordan ULg; Thiry, Aline ULg; Macq, Hadrien et al

Report (2015)

This report presents a study case research done in the "Evaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture" in Wallonia-Brussel Federation.

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See detailLessons Learned from Heat Balance Analysis for Holzkirchen Twin Houses Experiment
Masy, Gabrielle; Rehab, Imane ULg; Andre, Philippe ULg et al

in Energy Procedia (2015)

Holzkirchen full scale dynamic experiments were conducted in the framework of IEA Annex 58 research program with the aim to obtain and apply a high quality experimental dataset for model validation of ... [more ▼]

Holzkirchen full scale dynamic experiments were conducted in the framework of IEA Annex 58 research program with the aim to obtain and apply a high quality experimental dataset for model validation of full scale buildings. A first experiment was conducted in August 2013. Two identical houses were submitted to a side by side experiment, one with blinds up, one with blinds down. That first experience lasted 42 days including an initialization period, a Randomly Ordered Logarithmic Binary Sequence of heat inputs (ROLBS), and a re-initialization followed by a free-float period. A second experiment was conducted in April 2014 in one of the two houses, with higher levels of heating power in the South oriented zones and imposed indoor temperatures in the North oriented zones. Simulations were performed with EES Engineering Equation Solver using simplified RC dynamic models. The discrepancies observed between simulated results and measured data were first explained through a deeper analysis of thermal bridges, a better assessment of solar heat gains and a better assessment of the air duct heat losses. In the second experiment, the results revealed an underestimation of the building transmission heat losses. A candidate explanation might be the air stratification which would enhance heat losses on the ceiling side. A modelization of the upper and lower room air layers was introduced. The resulting simulated indoor temperature profiles were in accordance with the measurements. A complete breakdown of heat losses and heat gains was computed for both houses, using measured temperatures as input data for the simulation. [less ▲]

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See detailEvaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture: le cas de Jodoigne-Incourt
Thiry, Aline ULg; Halin, Jordan ULg; Fallon, Catherine ULg et al

Report (2015)

This report presents a study case research done in the "Evaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture" in Wallonia-Brussel Federation.

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See detailPalliative Radiotherapy Delivery Technologies
GULYBAN, Akos ULg; Mackenzie, Marc; Mathot, Michel et al

in Fairchild, Alysa (Ed.) Palliative Radiation Therapy: Utilization of Advanced Technologies (2015)

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See detailEvaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture: le cas d’Ixelles
Thiry, Aline ULg; Halin, Jordan ULg; Fallon, Catherine ULg et al

Report (2015)

This report presents a study case research done in the "Evaluation du décret du 30 avril 2009 relatif au développement des pratiques de lecture" in Wallonia-Brussel Federation.

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See detailThe impact of oregano (Origanum heracleoticum) essential oil and carvacrol on virulence gene transcription by Escherichia coli O157:H7
Mith, Hasika; Clinquart, Antoine ULg; Zhiri, Abdesselam et al

in FEMS Microbiology Letters (2015), 362

The aim of the current study was to determine, via reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis, the effect of oregano essential oil (Origanum heracleoticum) and ... [more ▼]

The aim of the current study was to determine, via reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis, the effect of oregano essential oil (Origanum heracleoticum) and carvacrol, its major component, on the expression of virulence-associated genes in enterohaemorrhagic Escherichia coli (EHEC) O157:H7 ATCC strain 35150. Both oregano oil and carvacrol demonstrated their efficacy firstly, by inhibiting the transcription of the ler gene involved in up regulation of the LEE2, LEE3 and LEE4 promoters and of attaching and effacing lesions and secondly by decreasing both Shiga toxin and fliC genes expression. In addition, a decrease in luxS gene transcription involved in quorum sensing was observed. These results were dose dependent and showed a specific effect of O. heracleoticum and carvacrol in downregulating the expression of virulence genes in EHEC O157:H7. These findings suggest that oregano oil and carvacrol have the potential to mitigate the adverse health effects caused by virulence gene expression in EHEC O157: [less ▲]

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See detailStepwise evolution of Paleozoic tracheophytes from South China: Contrasting leaf disparity and taxic diversity
Xue, Jinzhuang; Huang, Pu; Ruta, Marcello et al

in Earth-Science Reviews (2015), 148

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See detailRespiratory Motion, Anterior Heart Displacement and Heart Dosimetry: Comparison Between Prone (Pr) and Supine (Su) Whole Breast Irradiation
Lakosi, Ferenc; GULYBAN, Akos ULg; Janvary, Levente et al

in Pathology Oncology Research (2015)

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See detailCrystallisation-driven self-assembly of poly(2-isopropyl-2- oxazoline)-block-poly(2-methyl-2-oxazoline) above the LCST
Legros, Camille ULg; De Pauw-Gillet, Marie-Claire ULg; Tam, Kam Chiu et al

in Soft Matter (2015)

The solution behaviour in water of a polyoxazoline-type block copolymer, namely poly(2- isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline), denoted as P(iPrOx-b-MeOx), above the lower critical ... [more ▼]

The solution behaviour in water of a polyoxazoline-type block copolymer, namely poly(2- isopropyl-2-oxazoline)-block-poly(2-methyl-2-oxazoline), denoted as P(iPrOx-b-MeOx), above the lower critical solution temperature (LCST) of the PiPrOx block was exploited to induce a temporary or permanent self-assembly. Spherical micelles were first obtained and could be disassembled in a reversible manner when kept for a short period of time (i.e. t < 1h30) above the LCST, and cooled down to room temperature. In contrast, annealing the copolymer solution for more than 1h30 at 65 °C induced the crystallisation of the PiPrOx block, as evidenced by wide angle X-ray scattering (WAXS) experiments. This crystallisationdriven self-assembly phenomenon resulted in different morphologies, including spherical and distorted crystallised micelles and micron-size fibers, their relative proportion varying with annealing time. Formation of micron-size range fiber-like structures might be explained by a re-organization of parent crystallised micelles. The crystal structure, as determined by WAXS, appeared to be identical to that of the PiPrOx homopolymer. [less ▲]

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