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See detailTowards an Australian Philosophy. Constructive Appropriation of Enlightenment Thinking in Murray Bail's The Pages
Herbillon, Marie ULg

in Tunca, Daria; Wilson, Janet (Eds.) Under Construction. Postcolonial Gateways and Walls (2016)

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See detailKinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35.
Marcoccia, Francesca; Bottoni, Carlo; Sabatini, Alessia et al

in Antimicrobial agents and chemotherapy (2016), 60(4), 2366-72

Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized ... [more ▼]

Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized, and their kinetic parameters were compared with those of the NDM-1 wild type. Thekcat,Km, andkcat/Kmvalues calculated for the two mutants were slightly different from those of the wild-type enzyme. Interestingly, thekcat/Kmof NDM-1(I35S)for loracarbef was about 14-fold higher than that of NDM-1. Far-UV circular dichroism (CD) spectra of NDM-1 and NDM-1(I35T)and NDM-1(I35S)enzymes suggest local structural rearrangements in the secondary structure with a marked reduction of alpha-helix content in the mutants. [less ▲]

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See detailHeterogeneous bedrock investigation for a closed-loop geothermal system: A case study
Radioti, Georgia ULg; Delvoie, Simon ULg; Charlier, Robert ULg et al

in Geothermics (2016)

This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The ... [more ▼]

This paper investigates bedrock heterogeneity by applying three different geophysical approaches, in order to study the long-term behaviour and the interaction between closed-loop geothermal systems. The investigated site consists of four boreholes equipped with geothermal pipes on the campus of University of Liege, Belgium. The first approach includes acoustic borehole imaging, gamma-ray logging and cuttings observation and results to a detailed fracture characterisation, rock identification and layer dip angle determination. The second approach consists of measuring the thermal conductivity of cuttings at the laboratory. Study of cuttings thermal conductivity measurements can contribute to bedrock heterogeneity knowledge concerning the transition of one formation to another and the layer dipping. The third approach is based on high-resolution temperature profiles, measured during the hardening of the grouting material and the recovery phase of a Distributed Thermal Response Test. Through this approach a correlation of the temperature profiles to the geological characteristics of the surrounding bedrock is identified. The analysis of this correlation can provide information on fractured zones, alternation of different rock types and layering dipping. This latter approach can be easily applied on closed-loop geothermal systems to characterise the bedrock and investigate its heterogeneity as well as contribute to the their long-term behaviour prediction and to the optimisation of their efficiency. [less ▲]

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See detailA re-examination of O. Cairo JdE 72460 (= O. Cairo SR 1475). Ending the quest for a 19th Dynasty queen’s tomb in the Valley of the Kings
Dorn, Andreas; Polis, Stéphane ULg

in Collombert, Philippe; Lefèvre, Dominique; Polis, Stéphane (Eds.) et al Aere perennius. Mélanges égyptologiques en l'honneur de Pascal Vernus (2016)

In this paper, we offer a new interpretation for O. Cairo JdE 72460. Based on a discussion of the expressions used for measuring distances in the New Kingdom documentation, we explore the various possible ... [more ▼]

In this paper, we offer a new interpretation for O. Cairo JdE 72460. Based on a discussion of the expressions used for measuring distances in the New Kingdom documentation, we explore the various possible translations. We then try to map the abstract relationships between places as well as the related measurements onto actual archeological structures. We come to the conclusion that this ostracon might be linked to work in progress inside KV 5. [less ▲]

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See detailJack-of-all-trades effects drive biodiversity-ecosystem multifunctionality relationships in European forests.
van der Plas, Fons; Manning, Peter; Allan, Eric et al

in Nature communications (2016), 7

There is considerable evidence that biodiversity promotes multiple ecosystem functions (multifunctionality), thus ensuring the delivery of ecosystem services important for human well-being. However, the ... [more ▼]

There is considerable evidence that biodiversity promotes multiple ecosystem functions (multifunctionality), thus ensuring the delivery of ecosystem services important for human well-being. However, the mechanisms underlying this relationship are poorly understood, especially in natural ecosystems. We develop a novel approach to partition biodiversity effects on multifunctionality into three mechanisms and apply this to European forest data. We show that throughout Europe, tree diversity is positively related with multifunctionality when moderate levels of functioning are required, but negatively when very high function levels are desired. For two well-known mechanisms, 'complementarity' and 'selection', we detect only minor effects on multifunctionality. Instead a third, so far overlooked mechanism, the 'jack-of-all-trades' effect, caused by the averaging of individual species effects on function, drives observed patterns. Simulations demonstrate that jack-of-all-trades effects occur whenever species effects on different functions are not perfectly correlated, meaning they may contribute to diversity-multifunctionality relationships in many of the world's ecosystems. [less ▲]

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See detailLe scribe et le peintre. À propos d'un scribe qui ne voulait pas être pris pour un peintre
Laboury, Dimitri ULg

in Collombert, Philippe; Lefèvre, Dominique; Polis, Stéphane (Eds.) et al Aere perennius. Mélanges égyptologiques en l'honneur de Pascal Vernus (2016)

Using the famous signature of the scribe Merira in the tomb of the High priest of Nekhbet Setau at Elkab (T. Elkab 4) as a starting point, the article aims at reassessing the status of artists, and more ... [more ▼]

Using the famous signature of the scribe Merira in the tomb of the High priest of Nekhbet Setau at Elkab (T. Elkab 4) as a starting point, the article aims at reassessing the status of artists, and more specifically of painters, in Ancient Egyptian social representation as well as in the discourse of pharaonic scribes [less ▲]

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See detailLes codices médicaux grecs de petit format en parchemin dans l'Egypte byzantine
Marganne, Marie-Hélène ULg

in Davoli, Paola; Pellé, Natascia (Eds.) Polymatheia. Studi offerti a Mario Capasso (2016)

After an examination of the literary evidence on parchment notebooks containing medical recipes, this paper provides a repertoire of the small-format Greek medical parchment codices from Byzantine Egypt ... [more ▼]

After an examination of the literary evidence on parchment notebooks containing medical recipes, this paper provides a repertoire of the small-format Greek medical parchment codices from Byzantine Egypt. The internal and external charecteristics of these manuscripts are compared, in an effort to gather information on their context of production and use. [less ▲]

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See detailAn age-calibrated definition of chronic kidney disease: Rationale and benefits.
DELANAYE, Pierre ULg; Glassock, Richard; Pottel, H et al

in Clinical Biochemist. Reviews (2016), 37(1),

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See detailGPR101 mutations are not a frequent cause of congenital isolated growth hormone deficiency
Castinetti, F; Daly, Adrian ULg; Stratakis, CA et al

in Hormone & Metabolic Research (2016)

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See detailBreast cancer in a male to female transsexual patient with a BRCA2 mutation
CORMAN, Vinciane ULg; Potorac, Iulia ULg; Manto, Florence ULg et al

in Endocrine-Related Cancer (2016)

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See detailLA PARTICIPATION DES USAGERS COMME LEVIER DE L’INNOVATION DANS LES SERVICES PUBLICS : LE CAS DE LA GÉOMATIQUE WALLONNE
Fallon, Catherine ULg; Calay, Vincent

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2016), 26/27

La numérisation des données géographiques est une de ces techniques récentes qui transforment à la fois la structure politico-administrative et la construction des politiques elles-mêmes en transformant ... [more ▼]

La numérisation des données géographiques est une de ces techniques récentes qui transforment à la fois la structure politico-administrative et la construction des politiques elles-mêmes en transformant le réseau d’action publique. Ces données peuvent être utilisées dans la plupart des politiques, pourvu que les questions de distribution territoriales y soient pertinentes : on parle en ce sens d’une « géomatisation » de l’action publique. Le cadre européen avec la directive INSPIRE a donné l’impulsion et définit le cadre de référence pour une refonte des processus de production et de diffusion des données géographiques numériques. Les états doivent chacun établir une infrastructure de données géographiques numériques pour assurer l’interopérabilité entre bases de données et faciliter la diffusion, la disponibilité, l'utilisation et la réutilisation de l’information géographique au niveau de leur territoire et en Europe. En Belgique, ce sont les régions - et le niveau fédéral pour ses compétences - qui ont hérité de cette responsabilité : leurs données doivent être mises à disposition des utilisateurs, qu’ils soient décideurs ou citoyens dans des formats harmonisés afin d'en faciliter l'utilisation par tous et il faut aussi définir les principes d’échange, de tarification et les conditions d’utilisation propres à faciliter l’accès aux données et aux services en ligne. Les données géographiques numérisées ont ceci de particulier qu’elles sont produites de façon décentralisées par des acteurs publics mais aussi privés, lesquels cherchent à peser sur les choix stratégiques des autorités régionales. Au niveau de la Région wallonne a été mis en place récemment un ensemble de structure de coopération avec les usagers, les entreprises, et les autorités locales. L’administration a créé en son sein des groupes de travail transversaux pour améliorer l’intégration entre les approches thématiques contrôlées par les différentes directions. Le projet d’article trouve son origine dans l’accompagnement assuré par le SPIRAL au Département de la géomatique de la Région wallonne dans le cadre de la rédaction du plan stratégique et du plan opérationnel de la géomatique wallonne (2013-2015). L’article prendra appui sur les principes de la sociologie de la traduction (Callon, 1986) pour proposer une analyse des lieux et des processus qui contribuent à mettre en place une « gouvernance en réseau » mobilisant une logique d’innovation publique (Sørensen et al. 2011), sans suspendre pour autant les formes de coordination hiérarchiques et contractuelles. [less ▲]

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See detailTemperature assessment of a vertical steel member subjected to localised fire
Dumont, Fabien ULg; Wellens, Eric ULg; Franssen, Jean-Marc ULg

Textual, factual or bibliographical database (2016)

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See detailEnvironmental Impact Assessment of Rail Freight Intermodality
Merchan Arribas, Angel ULg; Belboom, Sandra ULg; Léonard, Angélique ULg

in Pombo, Joao (Ed.) The Third International Conference on Railway Technology: Research, Development and Maintenance (2016)

The European Commission’s White Paper on transport seeks to achieve an efficient and sustainable balance between the various transport modes. In this context, BRAIN-TRAINS is a project supported by ... [more ▼]

The European Commission’s White Paper on transport seeks to achieve an efficient and sustainable balance between the various transport modes. In this context, BRAIN-TRAINS is a project supported by Belgian Federal Government that deals with rail freight intermodality, approaching the problem from an interdisciplinary perspective. BRAIN-TRAINS will be able to answer the transition involved in transportation in Belgium. To analyse the sustainability impact of rail freight intermodality in Belgium, the life cycle assessment methodology will be used. The rail freight system is divided in this paper into rail operation, rail equipment and rail infrastructure. This paper shows the methodology to calculate the transport emissions related with the energy consumption during the rail operation. [less ▲]

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See detailDelayed neuroendocrine sexual maturation in female rats after a very low dose of Bisphenol A through altered GABAergic neurotransmission and opposing effects of a high dose.
Franssen, Delphine ULg; GERARD, Arlette ULg; HENNUY, Benoit ULg et al

in Endocrinology (2016)

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event ... [more ▼]

Rat sexual maturation is preceded by a reduction of the interpulse interval (IPI) of gonadotropinreleasing hormone (GnRH) neurosecretion. This work aims at studying disruption of that neuroendocrine event in females after early exposure to a very low dose of Bisphenol A (BPA), a ubiquitous endocrine disrupting chemical. Female rats were exposed to vehicle or BPA 25 ng/kg.day, 25 g/kg.day, or 5 mg/kg.day from postnatal day (PND) 1 to 5 or 15. Exposure to 25 ng/kg.day of BPA for 5 or 15 days was followed by a delay in developmental reduction of GnRH IPI studied ex vivo on PND 20. After 15 days of exposure to that low dose of BPA, vaginal opening tended to be delayed. In contrast, exposure to BPA 5 mg/kg.day for 15 days resulted in a premature reduction inGnRHIPI and a trend toward early vaginal opening. RNAseq analysis on PND20 indicated that exposure to BPA resulted in opposing dose effectsonthemRNAexpression of hypothalamic genes involved inGABAA neurotransmission. The study of GnRH secretion in vitro in the presence of GABAA receptor agonist/antagonist confirmed an increased or a reduced GABAergic tone after in vivo exposure to the very low or the high dose of BPA, respectively. Overall, we show for the first time that neonatal exposure to BPA leads to opposing dose-dependent effects on the neuroendocrine control of puberty in the female rat. A very low and environmentally relevant dose of BPA delays neuroendocrine maturation related to puberty through increased inhibitory GABAergic neurotransmission. [less ▲]

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See detailInteractions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes
Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg; Lins, Laurence ULg et al

in Biochimie (2016), In Press

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became ... [more ▼]

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems. [less ▲]

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