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See detaille mythe de l'infaillibilité médicale menace sérieusement la sécurité du patient !
COUCKE, Philippe ULg

in Healthcare Executive (in press), 77

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See detailIdentification of cardiac repercussions after intense and prolonged concentric isokinetic exercise in young sedentary people.
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; Couffignal, Vincent et al

in Clinical physiology and functional imaging (in press)

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among ... [more ▼]

INTRODUCTION: Cardiopathies are the world's leading cause of mortality and morbidity. Although rare, cardiovascular accidents can occur during intense and infrequent sporting activity, particularly among those who are unaware of their heart condition. The development of cardiospecific biochemical markers has led to a reconsideration of the role of biology in the diagnosis of cardiovascular illnesses. The aim of this study therefore was, through the use of cardiac biomarker assays, to highlight the impact of sustained physical effort in the form of intense and prolonged concentric isokinetic exercise and to research potential cardiovascular risks. MATERIALS AND METHODS: Eighteen subjects participated in a maximal concentric isokinetic exercise involving 30 knee flexion-extensions for each leg. Five blood tests were taken to study the kinetics of the cardiac biomarkers. Haemodynamic parameters were measured continuously using a Portapres, and respiratory parameters were measured using a Sensormedics Vmax 29C. RESULTS: The results showed significant increases in the creatine kinase, myoglobin, homocysteine and haemoglobin cardiac markers. Evolutionary trends were also observed for the following biomarkers: NT-proBNP, myeloperoxydase and C-reactive protein. All the physiological parameters measured presented statistically significant changes. CONCLUSION: Isokinetic effort leads to the release of cardiac markers in the blood, but these do not exceed the reference values in healthy subjects. Maximal concentric isokinetic exercise does not, therefore, lead to an increased risk of cardiovascular pathologies. [less ▲]

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See detailManagement of osteoporosis of the oldest old.
Rizzoli, R.; Branco, J.; Brandi, M.-L. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (in press)

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional ... [more ▼]

This consensus article reviews the diagnosis and treatment of osteoporosis in geriatric populations. Specifically, it reviews the risk assessment and intervention thresholds, the impact of nutritional deficiencies, fall prevention strategies, pharmacological treatments and their safety considerations, the risks of sub-optimal treatment adherence and strategies for its improvement. INTRODUCTION: This consensus article reviews the therapeutic strategies and management options for the treatment of osteoporosis of the oldest old. This vulnerable segment (persons over 80 years of age) stands to gain substantially from effective anti-osteoporosis treatment, but the under-prescription of these treatments is frequent. METHODS: This report is the result of an ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis) expert working group, which explores some of the reasons for this and presents the arguments to counter these beliefs. The risk assessment of older individuals is briefly reviewed along with the differences between some intervention guidelines. The current evidence on the impact of nutritional deficiencies (i.e. calcium, protein and vitamin D) is presented, as are strategies to prevent falls. One possible reason for the under-prescription of pharmacological treatments for osteoporosis in the oldest old is the perception that anti-fracture efficacy requires long-term treatment. However, a review of the data shows convincing anti-fracture efficacy already by 12 months. RESULTS: The safety profiles of these pharmacological agents are generally satisfactory in this patient segment provided a few precautions are followed. CONCLUSION: These patients should be considered for particular consultation/follow-up procedures in the effort to convince on the benefits of treatment and to allay fears of adverse drug reactions, since poor adherence is a major problem for the success of a strategy for osteoporosis and limits cost-effectiveness. [less ▲]

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See detailComplementary biophysical tools to investigate lipid specificity in the interaction between bioactive molecules and the plasma membrane: A review
Deleu, Magali ULg; Crowet, Jean-Marc ULg; Nasir, Mehmet Nail ULg et al

in Biochimica et Biophysica Acta - Biomembranes (in press)

Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic ... [more ▼]

Plasma membranes are complex entities common to all living cells. The basic principle of their organization appears very simple, but they are actually of high complexity and represent very dynamic structures. The interactions between bioactive molecules and lipids are important for numerous processes, from drug bioavailablility to viral fusion. The cell membrane is a carefully balanced environment and any change inflicted upon its structure by a bioactive molecule must be considered in conjunction with the overall effect that this may have on the function and integrity of the membrane. Conceptually, understanding the molecular mechanisms by which bioactive molecules interact with cell membranes is of fundamental importance. Lipid specificity is a key factor for the detailed understanding of the penetration and/or activity of lipid-interacting molecules and of mechanisms of some diseases. Further investigation in that way should improve drug discovery and development of membrane-active molecules in many domains such as health, plant protection or microbiology. In this review, we will present complementary biophysical approaches that can give information about lipid specificity at a molecular point of view. Examples of application will be given for different molecule types, from biomolecules to pharmacological drugs. A special emphasis is given to cyclic lipopeptides since they are interesting molecules in the scope of this review by combining a peptidic moiety and a lipidic tail and by exerting their activity via specific interactions with the plasma membrane. [less ▲]

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See detailOne injection of platelet-rich plasma associated to a submaximal eccentric protocol to treat chronic jumper's knee
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in The Journal of sports medicine and physical fitness (in press)

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

INTRODUCTION: Jumper's knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. METHODS: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months after the infiltration, using a 10--point Visual Analogic Scale, clinical examinations with a pressure algometer, algofunctional scores (IKDC and VISA--P), functional assessments (isokinetic and optojump evaluations) and imagery (ultrasounds and MRI). The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub--maximal eccentric reeducation. RESULTS: Pain during daily activities significantly decreased with time. During functional evaluation, it decreased as well, but without significant functional improvement. No improvements in the imagery measurements were observed. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. CONCLUSION: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve symptoms of chronic jumper's knee in patients non--responsive to classical conservative treatments. [less ▲]

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See detailGenetics of beef and milk fatty acid composition
Soyeurt, Hélène ULg; Beitz, Donald

in The genetics of cattle (in press)

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See detailPolitiques du vivant, politiques de la nature : Foucault, Latour et les biopolitiques
Caeymaex, Florence ULg; Pieron, Julien ULg

in Worms, Frédéric; François, Arnaud (Eds.) Le moment du vivant (in press)

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See detailDevelopment of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach
Silva, Joana M.; Vandermeulen, Gaëlle; Oliveira, Vanessa G. et al

in Nanomedicine (in press)

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based ... [more ▼]

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based nanoparticles and mannose-grafted nanoparticles were formulated and physicochemically characterized. Immortalized and primary antigen-presenting cells were used to study nanoparticle internalization patterns. The endocytic pathways and intracellular trafficking followed by nanoparticles were also investigated. Results & discussion: Nanoparticles displayed mannose residues available for binding at the nanoparticle surface. Different nanoparticle internalization patterns by immortalized and primary antigen presenting cells were verified. Macropinocytosis, clathrin-mediated endocytosis, caveolin- and lipid raft-dependent endocytosis are involved in nanoparticles internalization. Nanoparticles demonstrate both endo-lysosomal and cytosolic localizations and a tendency to accumulate nearby the endoplasmic reticulum. Conclusion & future perspective: The developed nanoparticles might drive antigens to be presented through MHC class I and II molecules to both CD8+ and CD4+ T cells, favoring a complete and coordinated immune response. [less ▲]

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See detailRethinking Vulnerability Analysis and Governance with Emphasis on a Participatory Approach
Rossignol, Nicolas ULg; Delvenne, Pierre ULg; Turcanu, Catrinel

in Risk Analysis : An Official Publication of the Society for Risk Analysis (in press)

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An ... [more ▼]

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An analysis of the literature on vulnerability analysis allows us to formulate a threefold critique: first, vulnerability analysis has been treated separately in the natural and the technological hazards fields. This separation prevents vulnerability to unleash the full range of its potential, as it constraints appraisals into artificial categories and thus already closes down the outcomes of the analysis. Second, vulnerability analysis focused on assessment tools that are mainly quantitative, whereas qualitative appraisal is a key to assessing vulnerability in a comprehensive way and to informing policy-making. Third, a systematic literature review of case studies reporting on participatory approaches to vulnerability analysis allows us to argue that participation has been important to address the above, but it remains too closed down in its approach and would benefit from embracing a more open, encompassing perspective. Therefore, we suggest rethinking vulnerability analysis as one part of a dynamic process between opening-up and closing-down strategies, in order to support a vulnerability governance framework. [less ▲]

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See detailBeyond corruption. The everyday life of a justice of the peace court in the Democratic Republic of Congo
Rubbers, Benjamin ULg; Gallez, Emilie

in Olivier de Sardan, Jean-Pierre; De Herdt, Tom (Eds.) The games of the rule. The practical norms of real governance in Sub-Saharan Africa (in press)

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See detailBreed-specific hematologic reference intervals in healthy adult Dogue de Bordeaux dogs
Lavoué, Rachel; Geffré, A; Braun, JP et al

in Veterinary Clinical Pathology (in press)

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See detailLes Grecs ont-ils étudié le latin ? Quelques témoignages datant du Haut-Empire
Rochette, Bruno ULg

in Sans, Benoît; Foubert, Frédéric; Vanhalme, Charlotte (Eds.) Hommages à Ghislaine Viré (in press)

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See detailA New Shift-Share Method
Artige, Lionel ULg; Van Neuss, Leif ULg

in Growth and Change (in press)

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant ... [more ▼]

Shift-share analysis is a decomposition technique widely used in regional studies to quantify an industry-mix effect and a competitive effect on the growth of regional employment (or any other relevant variable) relative to the national average. This technique has always been subject to criticism for its lack of theoretical basis. This paper presents a critical assessment of the methods suggested by Dunn (1960) and by Esteban-Marquillas (1972) and proposes a new shift-share method, which separates out the two effects unambiguously. By way of illustration, we provide an application to manufacturing employment in the Belgian provinces between 1995 and 2007. [less ▲]

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See detailUrban governance adaptation in an old industrial city: Liège (Belgium)
Breuer, Christophe ULg; Halleux, Jean-Marie ULg; Teller, Jacques ULg

in Francese, Dora (Ed.) Napoli Citta Metropolitana (in press)

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See detailLa contribution du CHST à l'inventaire wallon des terrains potentiellement pollués
Defechereux, Olivier ULg; Peters, Arnaud ULg

in Actes du IXème Congrès de l’Association des Cercles francophones d’Histoire et d’Archéologie de Belgique (in press)

Detailed reference viewed: 35 (4 ULg)
See detailLa carte de Vandermaelen et le paysage industriel wallon à la fin de la première industrialisation
Peters, Arnaud ULg; Defechereux, Olivier ULg

in Actes du IXème Congrès de l’Association des Cercles francophones d’Histoire et d’Archéologie de Belgique (in press)

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See detailQuantification des politiques versus démocratisation de l’évaluation : Etude des plans de cohésion sociale en Wallonie
Fallon, Catherine ULg; Feron, Pauline

in Mespoulet, Martine (Ed.) Usages des chiffres dans l’action publique territoriale (in press)

L’usage des chiffres dans l’action publique (ou la « quantification du politique ») mobilise deux registres en tension : premièrement celui de la performance, où « le chiffre est conçu comme un acteur ... [more ▼]

L’usage des chiffres dans l’action publique (ou la « quantification du politique ») mobilise deux registres en tension : premièrement celui de la performance, où « le chiffre est conçu comme un acteur contribuant à encadrer l’action en restreignant les options soumises à délibération et les choix ouverts à la décision collective », et deuxièmement la démocratie, perçue comme « un facteur d’extension du débat public et d’accroissement des sphères d’exercice de la responsabilité politique des citoyens ». Ogien relève le renforcement de cette tension, tout en soulignant l’absence de démocratisation de la mesure elle-même. Afin de remédier à cet écueil, l’auteur propose que les citoyens, rarement pris en considération dans l’élaboration et la définition des termes de la mesure, soient parties prenantes « du système du chiffre qui sert à rendre compte de leur existence et de leur destinée ». Cette contribution analyse les modalités concrètes de cette tension dans le cadre de l’évaluation d’une politique régionale mise en place au niveau local, les plans de cohésion sociale (PCS) en Région wallonne (Belgique), en mobilisant les données recueillies lors de l’évaluation des PCS terminée en mars 2013 . En effet, un enjeu important des PCS était la mise en place d’un processus d’évaluation qui se voulait « participatif» . La participation citoyenne étant une notion centrale de la philosophie PCS, un des objectifs de la Direction interdépartementale de la cohésion sociale (DiCS – administration régionale en charge du programme) était de la promouvoir à travers toutes les étapes de mise en œuvre de cette politique, y compris pour l’évaluation d’impact, inspirée en cela par les propositions méthodologiques du Conseil de l’Europe. Dans un premier temps, le bureau régional de statistique avait développé un indicateur composite « d’accès aux droits sociaux fondamentaux » afin d’objectiver la clé de répartition des ressources entre les territoires locaux. Ce n’est que dans un second temps, en fin de programme, que la DiCS était sommée de produire une « évaluation participative » mesurant l’impact des actions réalisées à travers les PCS sur la cohésion sociale et le bien-être. L’article propose de confronter ces deux démarches d’évaluation : celle qui aboutit à un indicateur quantitatif fondé sur une logique statistique et l’approche participative favorisant l’expression des parties prenantes. [less ▲]

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See detailLouise de Savoie et la chambre des Bucoliques
Fagnart, Laure ULg

in Brioist, Pascal; Fagnart, Laure; Michon, Cédric (Eds.) Louise de Savoie (1476-1531) (in press)

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See detailMulti-Dimensional Vector Assignment Problems
Dokka, Trivikram; Crama, Yves ULg; Spieksma, Frits C.R.

in Discrete Optimization (in press)

We consider a special class of axial multi-dimensional assignment problems called multi- dimensional vector assignment (MVA) problems. An instance of the MVA problem is defined by m disjoint sets, each of ... [more ▼]

We consider a special class of axial multi-dimensional assignment problems called multi- dimensional vector assignment (MVA) problems. An instance of the MVA problem is defined by m disjoint sets, each of which contains the same number n of p-dimensional vectors with nonnegative integral components, and a cost function defined on vectors. The cost of an m-tuple of vectors is defined as the cost of their component-wise maximum. The problem is now to partition the m sets of vectors into n m-tuples so that no two vectors from the same set are in the same m-tuple and so that the sum of the costs of the m-tuples is minimized. The main motivation comes from a yield optimization problem in semi-conductor manufacturing. We consider a particular class of polynomial-time heuristics for MVA, namely the sequential heuristics, and we study their approximation ratio. In particular, we show that when the cost function is monotone and subadditive, sequential heuristics have a finite approximation ratio for every fixed m. Moreover, we establish smaller approximation ratios when the cost function is submodular and, for a specific sequential heuristic, when the cost function is additive. We provide examples to illustrate the tightness of our analysis. Furthermore, we show that the MVA problem is APX-hard even for the case m = 3 and for binary input vectors. Finally, we show that the problem can be solved in polynomial time in the special case of binary vectors with fixed dimension p. [less ▲]

Detailed reference viewed: 9 (2 ULg)