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Dictionnaire toponymique de la Wallonie liégeoise. A.
Book published by CRTD (2013)Detailed reference viewed: 23 (4 ULg)
Similar local and landscape processes affect both a common and a rare newt species
Denoël, Mathieu ; ; Cornet, Yves et al
in PLoS ONE (2013), 8(5), 62727
Although rare species are often the focus of conservation measures, more common species may experience similar decline and suffer from the same threatening processes. We tested this hypothesis by ... [more ▼]
Although rare species are often the focus of conservation measures, more common species may experience similar decline and suffer from the same threatening processes. We tested this hypothesis by examining, through an information-theoretic approach, the importance of ecological processes at multiple scales in the great crested newt Triturus cristatus, regionally endangered and protected in Europe, and the more common smooth newt, Lissotriton vulgaris. Both species were similarly affected by the same processes, i.e. suitability of aquatic and terrestrial components of their habitat at different scales, connectivity among breeding sites, and the presence of introduced fish. T. cristatus depended more on water depth and aquatic vegetation than L. vulgaris. The results show that environmental pressures threaten both common and rare species, and therefore the more widespread species should not be neglected in conservation programs. Because environmental trends are leading to a deterioration of aquatic and terrestrial habitat features required by newt populations, populations of the common species may follow the fate of the rarest species. This could have substantial conservation implications because of the numerical importance of common species in ecosystems and because commonness could be a transient state moving towards rarity. On the other hand, in agreement with the umbrella species concept, targeting conservation efforts on the most demanding species would also protect part of the populations of the most common species. [less ▲]Detailed reference viewed: 68 (23 ULg)
L'Hypotension orthostatique: 1ere partie: definition, symptomatologie, evaluation et physiopathologie.
; PHILIPS, Jean-Christophe ; Krzesinski, Jean-Marie et al
in Revue Médicale de Liège (2013), 68(2), 65-73
Orthostatic hypotension (OH) is defined by a drop in arterial blood pressure (BP) of at least 20 mmHg for systolic BP and 10 mmHg for diastolic BP after standing. Symptoms are generally quite typical, but ... [more ▼]
Orthostatic hypotension (OH) is defined by a drop in arterial blood pressure (BP) of at least 20 mmHg for systolic BP and 10 mmHg for diastolic BP after standing. Symptoms are generally quite typical, but may also be rather vague. Diagnosis may be easily made by the physician in his/ her office, and confirmed, if necessary, by more sophisticated measurements. Pathophysiology is generally rather complex, but mostly involves a defect in the autonomic nervous system, in its sympathetic component. Failure of peripheral vasoconstriction seems to play a more important role than the defect in reflex tachycardia. Causes of OH are multiples. OH may occur in healthy subjects, when exposed to exceptional circumstances, but is more generally associated with various diseases, either neurological disorders or pathologies characterized by hypovolemia. Medications can also aggravate the risk of OH, among which some antihypertensive or psychotropic agents. Elderly people, especially frailty subjects, are exposed to a high risk of OH, whose origin is often multifactorial, and this complication may have serious medical consequences. [less ▲]Detailed reference viewed: 14 (7 ULg)
Linagliptin plus metformin: a pharmacokinetic and pharmacodynamic evaluation.
in Expert Opinion on Drug Metabolism & Toxicology (2013), 9(3), 363-77
INTRODUCTION: The first-choice drug therapy in the management of type 2 diabetes is metformin . However, most patients require a combined therapy to reach and/or maintain targets of glucose control ... [more ▼]
INTRODUCTION: The first-choice drug therapy in the management of type 2 diabetes is metformin . However, most patients require a combined therapy to reach and/or maintain targets of glucose control. Dipeptidyl peptidase-4 (DPP-4) inhibitors, commonly referred to as gliptins, offer new options for combined therapy with metformin. Linagliptin is the most recently launched gliptin, with a unique pharmacokinetic (PK) profile characterized by negligible renal excretion and is now also available as a fixed-dose combination (FDC) with metformin. AREAS COVERED: An extensive literature search was performed to analyze the potential PK and pharmacodynamic interactions between linagliptin and metformin. Linagliptin and metformin may be administered together, either separately or as FDC supported by bioequivalence studies. Linagliptin and metformin are not prone to PK drug-drug interactions. Their coadministration improves blood glucose control more potently than either compound separately, without hypoglycemia and without increasing metformin-related gastrointestinal side effects. EXPERT OPINION: The combination linaglitpin plus metformin, if not contraindicated (renal failure), may be used as first-line or second-line therapy in the management of type 2 diabetes. That being said, the durability of the glucose-lowering effect of this combination needs to be further explored in long-term controlled trials. [less ▲]Detailed reference viewed: 6 (0 ULg)
Efficacy and safety of Jentadueto(R) (linagliptin plus metformin).
in Expert Opinion on Drug Safety (2013), 12(2), 275-89
INTRODUCTION: Metformin is the first-choice drug in the management of type 2 diabetes. However, most patients require a combined therapy to reach and/or maintain targets of glucose control. Dipeptidyl ... [more ▼]
INTRODUCTION: Metformin is the first-choice drug in the management of type 2 diabetes. However, most patients require a combined therapy to reach and/or maintain targets of glucose control. Dipeptidyl peptidase-4 (DPP-4) inhibitors offer new options for combined therapy with metformin. Linagliptin shares a similar pharmacodynamic (PD) profile with other gliptins, but has a unique pharmacokinetic (PK) profile characterized by negligible renal excretion. AREAS COVERED: An extensive literature search was performed to analyze the potential PK/PD interactions between linagliptin and metformin. They are not prone to PK drug-drug interactions. The two compounds may be administered together, either separately or using a fixed-dose combination (FDC) as shown by bioequivalence studies. The addition of linagliptin in patients not well controlled with metformin alone has proven its efficacy in improving glucose levels with a good safety profile. Initial co-administration of linagliptin plus metformin improves glucose control more potently than either compound separately, without hypoglycemia, weight gain or increased metformin-related gastrointestinal side effects. EXPERT OPINION: The linagliptin plus metformin combination may offer some advantages over the classical sulfonylurea-metformin combination. Even if linagliptin is safe in patients with renal impairment, the use of metformin (and thus of the linagliptin plus metformin FDC) is still controversial in this population. [less ▲]Detailed reference viewed: 2 (0 ULg)
Crises financiere, economique, sociale, societale, morale, des reactions en chaine.
in Revue Médicale de Liège (2013), 68(1), 1-3Detailed reference viewed: 3 (0 ULg)
Role limite des medicaments hypoglycemiants oraux dans le diabete de type 1.
in Revue Médicale de Liège (2013), 68(1), 16-21
Management of type 1 diabetes essentially relies upon intensive insulin therapy adjusted according to careful home blood glucose monitoring. The potential role of oral antidiabetic agents is controversial ... [more ▼]
Management of type 1 diabetes essentially relies upon intensive insulin therapy adjusted according to careful home blood glucose monitoring. The potential role of oral antidiabetic agents is controversial and what so ever is limited in type 1 diabetes. Nevertheless, metformin may still be useful in the presence of obesity and/or insulin resistance while acarbose could reduce the amplitude of glycaemic fluetuations, namely postprandial hyperglycaemia and late postmeal glycaemic nadir. Both drugs may also minimize weight gain that results from intensive insulin therapy. Finally, inhibitors of dipeptidyl peptidase-4 (glitpins), by inhibiting glucagon secretion, and inhibitors of renal SGLT2 cotransporters, thus promoting glucosuria independently of insulin, might also be beneficial in type 1 diabetes, although specific studies are still ongoing to verify this hypothesis. [less ▲]Detailed reference viewed: 10 (0 ULg)
Pharmacokinetic considerations for the treatment of diabetes in patients with chronic kidney disease.
in Expert Opinion on Drug Metabolism & Toxicology (2013)
Introduction: People with chronic kidney disease (CKD) of stages 3 - 5 (creatinine clearance < 60 ml/min) represent approximately 25% of patients with type 2 diabetes mellitus (T2DM), but the problem is ... [more ▼]
Introduction: People with chronic kidney disease (CKD) of stages 3 - 5 (creatinine clearance < 60 ml/min) represent approximately 25% of patients with type 2 diabetes mellitus (T2DM), but the problem is underrecognized or neglected in clinical practice. However, most oral antidiabetic agents have limitations in case of renal impairment (RI), either because they require a dose adjustment or because they are contraindicated for safety reasons. Areas covered: The author performed an extensive literature search to analyze the influence of RI on the pharmacokinetics (PK) of glucose-lowering agents and the potential consequences for clinical practice. Expert opinion: As a result of PK interferences and for safety reasons, the daily dose should be reduced according to glomerular filtration rate (GFR) or even the drug is contraindicated in presence of severe CKD. This is the case for metformin (risk of lactic acidosis) and for many sulfonylureas (risk of hypoglycemia). At present, however, the exact GFR cutoff for metformin use is controversial. New antidiabetic agents are better tolerated in case of CKD, although clinical experience remains quite limited for most of them. The dose of DPP-4 inhibitors should be reduced (except for linagliptin), whereas both the efficacy and safety of SGLT2 inhibitors are questionable in presence of CKD. [less ▲]Detailed reference viewed: 2 (0 ULg)
Metformin revisited: A critical review of the benefit-risk balance in at-risk patients with type 2 diabetes.
SCHEEN, André ; Paquot, Nicolas
in Diabètes & Métabolism (2013)
Metformin is unanimously considered a first-line glucose-lowering agent. Theoretically, however, it cannot be prescribed in a large proportion of patients with type 2 diabetes because of numerous ... [more ▼]
Metformin is unanimously considered a first-line glucose-lowering agent. Theoretically, however, it cannot be prescribed in a large proportion of patients with type 2 diabetes because of numerous contraindications that could lead to an increased risk of lactic acidosis. Various observational data from real-life have shown that many diabetic patients considered to be at risk still receive metformin and often without appropriate dose adjustment, yet apparently with no harm done and particularly no increased risk of lactic acidosis. More interestingly, recent data have suggested that type 2 diabetes patients considered at risk because of the presence of traditional contraindications may still derive benefit from metformin therapy with reductions in morbidity and mortality compared with other glucose-lowering agents, especially sulphonylureas. The present review analyzes the benefit-risk balance of metformin therapy in special populations, namely, patients with stable coronary artery disease, acute coronary syndrome or myocardial infarction, congestive heart failure, renal impairment or chronic kidney disease, hepatic dysfunction and chronic respiratory insufficiency, all conditions that could in theory increase the risk of lactic acidosis. Special attention is also paid to elderly patients with type 2 diabetes, a population that is growing rapidly, as older patients can accumulate several comorbidities classically considered contraindications to the use of metformin. A review of the recent scientific literature suggests that reassessment of the contraindications of metformin is now urgently needed to prevent physicians from prescribing the most popular glucose-lowering therapy in everyday clinical practice outside of the official recommendations. [less ▲]Detailed reference viewed: 11 (0 ULg)
Preliminary data on Viséan (Carboniferous) corals and brachiopods from the strata between the Djebel Begaa and the Gara et Itima (Eastern Tafilalt, Morocco)
; Denayer, Julien ; Mottequin, Bernard
in Document de l'Institut Scientifique, rabat (2013), 27Detailed reference viewed: 7 (3 ULg)
Preliminary data on plicathyridines (Brachiopoda) from the Frasnian of southern Belgium and the Middle East (Afghanistan, Iran)
Mottequin, Bernard ; Marion, Jean-Marc ;
in Documents scientifiques de l'Institut de Rabat (2013), 26Detailed reference viewed: 5 (5 ULg)
Etude rétrospective de 438 salariés diabétiques dans un service interentreprises luxembourgeois de santé au travail - Enquête sur la relation entre la maladie diabétique et la survenue d'une décision d'inaptitude, d'un arrêt maladie prolongé ou d'un accident de travail.
; Mairiaux, Philippe ;
in Archives des Maladies Professionnelles et de l'Environnement (2013), In press
A retrospective study was carried out from October 2004 until September 2006 in a Luxembourger occupational health service. The purposes of the medical checks performed during this period of time were ... [more ▼]
A retrospective study was carried out from October 2004 until September 2006 in a Luxembourger occupational health service. The purposes of the medical checks performed during this period of time were analysed as well as the related decision of occupational health practitioners. A total of 28244 persons attended the medical checks thereof 438 had diabetes (diabetes mellitus type 1 and type 2). The risk of being declared unfit for a job was compared in workers populations with and without diabetes. The probabilities to consult an occupational practitioner after a long-time sick leave (more than 6 weeks long) or after an accident at work were also compared in both workers populations. The Woolf’s method was used to adjust all odds ratios for age and sex. The proportions of persons with diabetes appear similar to those found by age in the general population, however the risk of being declared unfit for a job was significantly higher for persons with diabetic than for non-diabetic persons (OR=3.14 ; 95% CI [2.30 - 4.28]). In 84% cases, diabetes wasn’t the only cause of unfitness (comorbidities, vascular complications…). Diabetes represented a higher risk of a long time sick leave (OR=1.99 ; 95% CI [1.44 - 2.77]), but it didn’t lead to an significant risk of accident at work (OR=1.92 ; 95% CI [0.94 - 2.26]). Our results suggest that several employees with diabetes seemed to be restricted from certain jobs or couldn’t maintain their jobs. Most often, the occupational practitioners decisions were not solely justified by the diabetes but by the coexistence of complications or comorbidities. This last argument, associated with an increased risk to be on sick leave for a long period, stresses the importance of the preventive actions in diabetes. However, the prejudice of a higher risk of occupational accidents due to diabetics seems unfounded. [less ▲]Detailed reference viewed: 16 (2 ULg)
L'exploitation des mises à blanc résineuses sur cloisonnements et lit de branches pour protéger la capacité productive des sols forestiers et maîtriser les coûts de reboisement
; ; Claessens, Hugues
in Forêt Wallonne (2013), (122), 44-54
Les forestiers sont à la recherche de techniques d'exploitation innovantes, respectueuses des sols, de la régénération naturelle et des conditions de travail.Detailed reference viewed: 31 (12 ULg)
Stockage de carbone et flux de gaz à effet de serre en prairie (synthèse bibliographique)
Jerome, Elisabeth ; Beckers, Yves ; Bodson, Bernard et al
in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(1), 103-117
Grassland carbon (C) sequestration can play an important role in mitigating total greenhouse gas (GHG) emissions of livestock production systems. An accurate inventory of livestock production system ... [more ▼]
Grassland carbon (C) sequestration can play an important role in mitigating total greenhouse gas (GHG) emissions of livestock production systems. An accurate inventory of livestock production system contribution to GHG emissions requires to think in terms of global budget, by considering both the GHG sources and the mitigation potential trough grassland soil carbon sequestration. There is a huge variability in C and GHG balances of grasslands that is mainly due to management practices and climatic conditions. The present article shows that, to reduce the uncertainties of the results, long term measurements at the field scale are necessary. Also, it shows the importance of taking the fluxes of the three main GHGs (carbon dioxide, nitrous oxide, methane) into account when calculating the GHG budget. This article also highlights the need for a better understanding of the mechanisms driving the fluxes, in relation to environmental factors and management practices, in order to propose mitigation strategies able to enhance soil carbon sequestration in soils and to reduce methane and nitrous oxide emissions. [less ▲]Detailed reference viewed: 24 (7 ULg)
Total Current Blockade in an Ultracold Dipolar Quantum Wire
; ; et al
in Physical Review Letters (2013), 110
Cold-atom systems offer a great potential for the future design of new mesoscopic quantum systems with properties that are fundamentally different from semiconductor nanostructures. Here, we investigate ... [more ▼]
Cold-atom systems offer a great potential for the future design of new mesoscopic quantum systems with properties that are fundamentally different from semiconductor nanostructures. Here, we investigate the quantum-gas analogue of a quantum wire and find a new scenario for the quantum transport: Attractive interactions may lead to a complete suppression of current in the low-bias range, a total current blockade. We demonstrate this effect for the example of ultracold quantum gases with dipolar interactions. [less ▲]Detailed reference viewed: 11 (2 ULg)
Preserved automatic inhibition effect after 1 Hz repetitive transcranial magnetic stimulation over the supplementary motor area
D'Ostilio, Kevin ; CREMERS, Julien ; DELVAUX, Valérie et al
Background: It is widely accepted that medial frontal regions are involved in voluntary action control. Indeed, Sumner et al. (2007) have recently suggested that one of the mechanisms through which the ... [more ▼]
Background: It is widely accepted that medial frontal regions are involved in voluntary action control. Indeed, Sumner et al. (2007) have recently suggested that one of the mechanisms through which the supplementary motor area (SMA) contributes to voluntary control is automatic and unconscious motor inhibition. In this study, they administered a visuo-motor subliminal masked prime task (Eimer & Schlaghecken, 2003) to two patients with micro-lesions of the SMA and demonstrated an absence of automatic and unconscious inhibition as evoked by masked prime stimuli. This finding has been supported by neuroimaging data (D'Ostilio et al., 2012). Here, the aim of our research was to corroborate this result by means of a “virtual lesion” approach. Methods: For this purpose, we examined the effects of 1 Hz rTMS (train of 20 min; stimulus intensity 120 % of resting motor threshold) over the SMA of ten healthy volunteers, previously localized by functional magnetic resonance imaging (fMRI), on reaction time (RT) performance in the subliminal masked prime task. The functional localizer experiment consisted of four blocks of sequential finger tapping and 15 s of rest after each block. Imaging data were analyzed with SPM 8 and then were imported into the Brainsight software version 2.1.5. With such system, we were able to navigate across the subjects’ brain. The peak voxel in the SMA for each subject (at a statistical threshold of p < 0.05 uncorrected) was used as a target point for the rTMS session. Results: The mean motor threshold was 50.9 % of maximal stimulator output (SD: ± 4.86 %). Wilcoxon tests showed a significant effect of compatibility on RTs (sham: Z = 2.7, p = 0.007; rTMS: Z = 2.8, p = 0.005) and accuracy rate (sham: Z = 2.5, p = 0.01; rTMS: Z = 2.1, p = 0.03), subjects being slower and making more errors in compatible trials (sham: 391.64 ± 52 ms, 87.3 % of accuracy; rTMS: 396.66 ± 37 ms, 86.3 % of accuracy) in comparison to incompatible trials (sham: 357.45 ± 36 ms, 92.5 % of accuracy; rTMS: 356.25 ± 28 ms, 92.7 % of accuracy), suggesting motor inhibition. However, this NCE was preserved after rTMS over the SMA (RTs: Z = 0.87, p = 0.39; accuracy rate: Z = 0.71, p = 0.47). Conclusions: We conclude that long trains of low intensity 1 Hz rTMS did not affect the modulation of RT by subliminal stimuli, suggesting that the SMA might not be mandatory for the implementation of this automatic process. The limitation of this study is relative to the neural efficacy argument because we are not sure that TMS was strong enough to disturb the redundant organizational processing in the SMA or that other regions were not able to compensate for the virtually lesioned area. [less ▲]Detailed reference viewed: 23 (1 ULg)
Rapid prenatal diagnosis of fetal Zellweger syndrome by biochemical tests, complementation studies, and molecular analyses.
; ; et al
in Prenatal Diagnosis (2013), 33(2), 201-3Detailed reference viewed: 10 (0 ULg)
Reproductive and productive performances of the stress-negative Piétrain pigs in the tropics: the case of Vietnam
Do Duc, Luc ; ; et al
in Animal Production Science (2013), 53(2), 173-179
The objective of the present study is to investigate the reproduction, production and semen traits of the stressnegative Piétrain line of pigs in the north of Vietnam, as well as to identify various ... [more ▼]
The objective of the present study is to investigate the reproduction, production and semen traits of the stressnegative Piétrain line of pigs in the north of Vietnam, as well as to identify various factors (halothane genotype, generationorigin, parity, sex and month of the year) acting on these traits. The experiment was carried out on a purebred nucleus on Dong Hiep farm, Haiphong province in Vietnam. The reproduction performances and the sperm quality measures were based on 12 sows and 5 boars imported from Belgium as well as on 29 sows and 14 boars born in Vietnam, while the production performances were recorded only from 251 animals born in Vietnam. No significant differences were observed between halothane genotypes of sows for reproduction traits (P>0.0578). At the age of 7.5 months, bodyweight, backfat thickness and longissimus depth (7.5) of homozygous-dominant pigs were higher (P<0.05) than in heterozygotes. Homozygous-dominant boars had higher total number of spermatozoa than heterozygote boars (P < 0.05); similarly, Vietnam boars also presented higher total number of spermatozoa values than Belgium boars (P < 0.001). Vietnam sows had longer duration of pregnancy, more piglets born alive and heavier litter weight of weaning than Belgium sows (P < 0.01). Bodyweight at birth, at weaning, at 2, 5.5 and 7.5 months of age increased from the first to third parity (P < 0.05). Gilts had more lean meat than intact boars (P < 0.01). Compared with observations made in temperate countries, the reproduction and production performances, sperm concentration and total number of spermatozoa of stress-negative Piétrain pigs were reduced, whereas lean meat percentage was not affected. This might be due to the different climate, although improving values for animals born in Vietnam might indicate adaptation of the animals and/or of the technicians with that breed. The results support the interest of the use of this new Piétrain line in tropical countries with ecological and climatic conditions similar to Vietnam. [less ▲]Detailed reference viewed: 28 (3 ULg)
Development and aging of the Kisspeptin-GPR54 system in the mammalian brain: what are the impacts on female reproductive function?
; Desroziers, Elodie
in Frontiers in Neuroendocrine Science (2013)Detailed reference viewed: 15 (1 ULg)