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See detailNouveautés en allergologie. L'allergie moléculaire.
GADISSEUR, Romy ULg

Conference (2014, October 01)

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See detailMulticenter implementation of geriatric assessment in Belgian patients with cancer: A survey on treating physicians' general experiences and expectations.
Kenis, Cindy; Heeren, Pieter; Bron, Dominique et al

in Journal of geriatric oncology (2014), 5(4), 431-438

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A ... [more ▼]

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A survey was carried out in 9 Belgian hospitals, which participated in a national GA implementation project focusing on older patients with cancer. A newly developed questionnaire was completed by their treating physicians. Data collection comprised of reviewing hospital data, general respondent data, and treating physicians' general experiences and expectations regarding GA. Descriptive statistics were calculated. RESULTS: Eighty-two physicians from 9 hospitals participated. The GA team composition can vary substantially, with a nurse as core member. Ideally, all older patients with cancer in whom a treatment decision is necessary, should benefit from the GA. Nearly all GA domains are reported as very important. Availability of GA results can be improved. Treating physicians want geriatricians to coordinate geriatric recommendations related to the identified GA problems, and expect from trained healthcare workers (THCWs) to collect GA data, to report GA results, and to follow-up the implementation of geriatric recommendations. CONCLUSION: This study identifies relevant information for improving the implementation of GA in older patients with cancer in Belgium and reveals priorities for a THCW from the treating physician's point of view. To increase the effectiveness of GA, further efforts are needed to improve the implementation of geriatric recommendations. [less ▲]

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See detailMicrocrystalline cellulose, a direct compression binder in a quality by design environment—A review
Thoorens, Grégory; Krier, Fabrice ULg; Leclercq, Bruno et al

in International Journal of Pharmaceutics (2014), 473(1-2), 64-72

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See detailLiège. Où s’amorce le nouveau modèle économique wallon ? Où s’échoue le vieux modèle politique wallon ?
Artige, Lionel ULg

Conference given outside the academic context (2014)

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See detailLes châteaux industriels dans le bassin liégeois : typologie et étude de cas
Destatte, Julien ULg; Peters, Arnaud ULg; Van Velthem, Lionel

Conference (2014, October 01)

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See detailVelocity and turbulence measurements for assessing the stability of riverbeds: a comparison between UVP and ADVP
Duma, Diana ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in 11th International Conference on Hydroscience & Engineering - "Hydro-Engineering for Environmental Challenges" (2014, October)

Maintaining the overall stability of active riverbeds requires a deep understanding of the complex interactions between turbulent flow forces and forces stabilizing the riverbed. Standard approaches do ... [more ▼]

Maintaining the overall stability of active riverbeds requires a deep understanding of the complex interactions between turbulent flow forces and forces stabilizing the riverbed. Standard approaches do not properly take into account the turbulence fluctuations in non-uniform flows, while these are of primary importance in the mechanisms determining the stability of stones. In a new approach, the flow forces are quantified by means of parameters combining explicitly the velocity and turbulence distributions over a certain water depth above the riverbed. In this paper, as an onset for using these newly developed bed stability parameters, we report on new experimental measurements of velocity and turbulent kinetic energy based on acoustic methods, whereas all previous uses at the new bed stability parameters relied on Laser PIV Techniques. For quasi-uniform and non-uniform flow conditions, velocity measurements were conducted with two complementary devices: an ultrasonic velocimeter probe (UVP) and an acoustic Doppler velocimeter profiler (ADVP). The results are compared and discussed in detail. A general consistency between the two types of measurements is obtained, while some discrepancies are highlighted close to the bed and tentative explanations are given. [less ▲]

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See detailHarmonia axyridis population study in agroecosystems
Vandereycken, Axel ULg; Fassotte, Bérénice ULg; Durieux, Delphine ULg et al

Poster (2014, October)

The Multicoloured Asian ladybird, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), is one of these species which was intentionally introduced for biological control and has spread from its native ... [more ▼]

The Multicoloured Asian ladybird, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), is one of these species which was intentionally introduced for biological control and has spread from its native range in Central and Eastern Asia to large parts of North and South America, Europe, and Africa. The decline of native species is linked to the spread and the aggressive behaviour of H. axyridis. From 2009, we evaluated the population densities of aphids predator and predator diversities, with a special focus on H. axyridis in agroecosystems of Wallonia (South of Belgium). First, field crops preferences of H. axyridis were determined. Later, changes linked to aphid’s predator populations over time were evaluated. Finally, H. axyridis population changes between two crop farming methods were also evaluated. Samplings performed in agroecosystems highlighted that the community of aphid's predator is composed of few dominant species: three coccinellids (Coccinella septempunctata L., P. quatuordecimpunctata L., and H. axyridis), one syrphid (Episyrphus balteatus De Geer), and one chrysopid (Chrysoperla carnea Stephens). We demonstrated that H. axyridis do not invade all crops at the same rate, maize and broad bean being more infested than wheat and potato at both larval and adult stages. Moreover, H. axyridis populations in maize have strongly increased from 2009 to 2011. Finally, we showed that organic farming do not contribute to increase the abundance of H. axyridis but leads to increase the total abundance of aphid’s natural enemies. [less ▲]

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See detailInvestigation of shear stress evolution during neotissue growth in a perfusion bioreactor using 3d multiphysics modeling
Guyot, Yann ULg; Papantoniou, Ioannis; Schrooten, Jan et al

Conference (2014, October)

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See detailStudy of sex ratio and morphotypes of the Multicoloured Asian Ladybird, Harmonia axyridis Pallas in Belgian maize
Vandereycken, Axel ULg; Fassotte, Bérénice ULg; Barsics, Fanny ULg et al

Poster (2014, October)

Several insect species are known to have different morphotypes, an adaptation to heterogeneities in changing environments. This phenotypic plasticity could be a factor used by the Multicoloured Asian ... [more ▼]

Several insect species are known to have different morphotypes, an adaptation to heterogeneities in changing environments. This phenotypic plasticity could be a factor used by the Multicoloured Asian Ladybird, which is considered as an invasive species in Europe since its introduction in the 80’s. Harmonia axyridis has four major morphotypes: 2 melanic forms, conspicua and spectabilis; and 2 non-melanic, succinea and axyridis. In Belgium, only the three first are observed. Literature reports variations in morphotype frequencies, across native and introduced strains. These variations seem to be linked to climate (geographical and seasonal variation), with non-melanic forms being the most abundant in hot and arid climate. This study focused on the variation of morphotype abundance in H. axyridis according to season, field and gender. Adult ladybirds were caught from mid-July to mid-October 2012 into 5 maize fields. The proportions of observed morphotypes were compared according to the sampling season. The abundance of morphotypes was not significantly different through the fields; the observed ratios were 81.6%, 15% and 3.4% for succinea, spectabilis and conspicua respectively. Succinea was the most observed morphotype (χ2=755.8; P<0.001). The total number of collected males and females was the same with ratios of 48.2% and 51.8%: (χ2=0.93; P=0.33). The sex ratio was also not significantly different for each morphotype. There was no evolution of melanic and non-melanic form ratio according to the season, with 25.6% of melanic form in summer and 20.6% in autumn (χ2=1.22; P=0.27). Our results seem to show that morphotype adaptation according to the climate is not observed for Belgian ladybirds. [less ▲]

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See detailData processing of vibrational chemical imaging for pharmaceutical applications.
Sacre, Pierre-Yves ULg; De Bleye, Charlotte ULg; Chavez, Pierre-François ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2014), 101

Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational ... [more ▼]

Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational spectroscopy to imaging techniques and allows therefore the visualization of distribution of compounds, crystallization processes. However, these techniques provide a huge amount of data that must be processed to extract the relevant information. This review presents fundamental concepts of hyperspectral imaging, the basic theory of the most used chemometric tools used to pre-process, process and post-process the generated data. The last part of the present paper focuses on pharmaceutical applications of hyperspectral imaging and highlights the data processing approaches to enable the reader making the best choice among the different tools available. [less ▲]

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See detailAn asymptotic expansion-based method for a spectral approach in equivalent statistical linearization
Canor, Thomas ULg; Blaise, Nicolas ULg; Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2014), 38

Equivalent linearization consists in replacing a nonlinear system with an equivalent linear one whose parameters are tuned with regard to the minimization of a suitable function. In particular, the ... [more ▼]

Equivalent linearization consists in replacing a nonlinear system with an equivalent linear one whose parameters are tuned with regard to the minimization of a suitable function. In particular, the Gaussian equivalent linearization expresses the properties of an equivalent linear system in terms of the mean vector and the covariance matrix of the responses, which are the unknowns of the optimization problem in a spectral approach. Even though the system has been linearized, the resulting set of equations is nonlinear. The computational effort in this method pertains to the solution of a possibly large set of nonlinear algebraic equations involving integrals and inversions of full matrices. This work proposes to develop and apply an asymptotic expansion-based method to facilitate and to improve the statistical linearization for large nonlinear structures. The proposed developments demonstrate that for slightly to moderately coupled nonlinear systems, the equivalent linearization can be applied with an appropriate modal approach and eventually seen as a convergent series initiated with the stochastic response of a main decoupled linear system. With this method, the computational effort is attractively reduced, the conditioning of the set of nonlinear algebraic equations is improved and inversion of full transfer matrices and repeated integrations are avoided. The paper gives a formal description of the method and illustrates its implementation and performances with the computation of stationary responses of nonlinear structures subject to coherent random excitation fields. [less ▲]

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See detailRetrospective analysis of a suburban out-ofhours clinic in Belgium
Belche, Jean-Luc ULg; Berrewaerts, Marie-Astrid ULg; Burette, Philippe ULg et al

in Acta Clinica Belgica (2014), 69(5), 341-347

Introduction: In many countries, out-of-hours medical care is under scrutiny. The aim of this article is to study the activities recorded by the first out-of-hours clinic that has been opened, as a pilot ... [more ▼]

Introduction: In many countries, out-of-hours medical care is under scrutiny. The aim of this article is to study the activities recorded by the first out-of-hours clinic that has been opened, as a pilot study, in two Walloon communes. Material and method: A retrospective analysis of anonymized data was conducted for 2009. Coding of diagnoses was conducted using the International Classification of Primary Care (ICPC-2). Results: A total of 3949 contacts were recorded in 2009 with the out-of-hours clinic, 3294 related to inhabitants of the two communes covered, which was equivalent to 13% of the total population in question. Compared to 7.2% of contacts between midnight and 8 a.m., 82.9% of contacts took place between 8 a.m. and 9 p.m., and 91.6% of contacts were handled locally, with only 8.4% resulting in hospitalization. In addition, 52% of contacts were with patients aged between 25 and 65; 29.9% of contacts were with paediatric patients (,15 years). Patients over the age of 65 made up 18% of contacts. The most common pathologies were respiratory (R). Analysis of flu diagnoses identified two epidemic peaks. Discussion: The suburban out-of-hours clinic studied fulfilled an important role in managing the demand for health care. The large majority of health problems were resolved locally, and the inhabitants did not need to go to hospital. Appointments between midnight and 8 a.m. were in the minority, which points towards adjusting the organization of the out-of-hours service during the night. The geriatric population is not highly over-represented contrary to what might be expected considering its largest number of pathologies. The on-call doctor’s skills profile should take account of the populations and morbidities encountered. Out-ofhours clinics could possibly play a sentinel role in terms of flu epidemics. Conclusion: This study describes a pilot suburban out-of-hours clinic which met three of recommendations set by the KCE in its report on out-of-hours care in general medicine: the organization of an out-of-hours clinic with logistical support, the use of a single telephone number and merging out-of-hours areas. While debate exists on the management of out-of-hours care, this study provides evidence on the role of the physician during these hours. [less ▲]

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See detailEGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Paye, Alexandra ULg; Truong, Alice ULg; Yip, Cassandre ULg et al

in Cancer research (2014)

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of ... [more ▼]

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of cancer cell proliferation through CDK4 activation and retinoblastoma protein (Rb) inactivation. We also determine a functional link between MT4-MMP and the growth factor receptor EGFR. Mechanistic experiments revealed direct association of MT4-MMP and its positive effects on EGFR phosphorylation in response to TGF- and EGF in cancer cells. Notably, the effects of MT4-MMP on proliferation and EGFR activation did not rely on metalloprotease activity. Clinically, MT4-MMP and EGFR expression were correlated in human triple negative breast cancer specimens. Altogether our results identify MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation. [less ▲]

Detailed reference viewed: 16 (4 ULg)