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See detailObservation and simulation of ethane at 22 FTIR sites
Mahieu, Emmanuel ULg; Franco, Bruno ULg; Pozzer, Andrea et al

Conference (2017, May 30)

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See detailRégulation de voies de signalisation par deux acteurs de la voie Nonsense-mediated Decay, Dhx34 et Nbas: la cas particulier de l'adénohypophyse.
Windhausen, Thomas ULg

Doctoral thesis (2017)

In eukaryotes, biosynthesis of functional mRNAs is the core process of genetic expression and is monitored by highly conserved pathways that prevent appearance of aberrant mRNAs. Amongst them the Nonsense ... [more ▼]

In eukaryotes, biosynthesis of functional mRNAs is the core process of genetic expression and is monitored by highly conserved pathways that prevent appearance of aberrant mRNAs. Amongst them the Nonsense-Mediated Decay (NMD) pathway is the surveillance mechanism that detects and degrades mRNAs containing premature termination codons (PTCs). The translation of transcripts containing such nonsense codon within the coding sequence would leads to the production of C-terminally truncated proteins that could exhibit dominant negative or gain-of-function activities. The NMD is thus a key determinant of the phenotypic outcome of numerous diseases involving PTCs such as the β-thalassemia, the Duchenne muscular dystrophy or even some cancers. In addition to its quality control function degrading aberrant mRNA, the NMD is also involved in the abundance regulation of several physiological transcripts. For example the NMD is involved in the regulation of the concentration of splicing factors in a process called AS-NMD (Alternative splicing- Nonsense-mediated Decay), establish a threshold for some stress responses such as the UPR pathway (Unfolded Protein Response) and constitute a defence mechanism against ARN(+) viruses. Despite tremendous studies, the study of the developmental and physiological impact of the NMD pathway is restrained due to the early lethality of the mammals embryos that underwent knock-out of one of the NMD actor. As an alternative model we propose Danio rerio which as a vertebrate with external development and a large panel of genetic inactivation methods is a wonderful model for developmental studies and represent a excellent tool to study the NMD pathway. Initial studies in zebrafish conducted by morpholino knock-down, showed that depletion of upf1, upf2, smg5, smg6, dhx34 or nbas leads to the NMD blockage and induce similar developmental defects mainly in brain, eyes and somites. Moreover, it’s has been showed that as in mammals the NMD in fish also implicated in the regulation of natural transcripts. We present here a functional study of two key actors of the NMD, Dhx34 and Nbas, in the interesting case of the pituitary gland development. In the present study, we shed light on the NMD pathway importance for the developmental process of the pituitary gland. Using in situ hybridization confirmed by RT-qPCR quantification, we observed that the NMD inactivation thought inhibition of two crucial actors of this surveillance pathway, Dhx34 and Nbas, lead to a hypertrophy of the gland coupled with a promotion of the anterior cell fates and a repression of the posterior fates at 2 dpf. We proved that this endocrine deregulation is due to a late general increase of the Sonic Hedgehog and Delta-Notch signalling during AH formation. In addition to previous works, our results show that the NMD pathway is required to control the activity diverse signalling pathways involved in the developmental process. As confirmation, we could observe serious abnormalities in a variety of tissues such as underdeveloped eyes, intestine, liver and skeleton, defects in brain, somites and vascular patterning. [less ▲]

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See detailRoundtable moderator: Global Competition amongst Standard Setting Organizations
Van Cleynenbreugel, Pieter ULg

Scientific conference (2017, May 30)

I chaired/moderated and guided a discussion between A. Chaouat (Technicolor), A. Ganesh (CEN/CENELEC), Y. Meniere (European Patent Office) and S. Haber (Stanford University). I prepared an introductory ... [more ▼]

I chaired/moderated and guided a discussion between A. Chaouat (Technicolor), A. Ganesh (CEN/CENELEC), Y. Meniere (European Patent Office) and S. Haber (Stanford University). I prepared an introductory statement and questions for each panelist, in addition to moderating the discussion. [less ▲]

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See detailLogical tools for descriptive psychology. Set theory and foundational mereology
Leclercq, Bruno ULg

Conference (2017, May 30)

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See detailPour un droit fondamental au logement : émergence et nuances
Quintart, Aurélie ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2017)

The fundamental right to housing is written in article 23 of our Constitution along with others social and economical rights since 1994. It is said to be a necessary component for the right to respect for ... [more ▼]

The fundamental right to housing is written in article 23 of our Constitution along with others social and economical rights since 1994. It is said to be a necessary component for the right to respect for human dignity. For the last decades, the right to housing has been quoted in many international declarations and conventions. However we still wonder: what is the real impact of this right to housing? How effective can it be? What interpretation can we give to case-law in this regard? We would like to bring some ideas and answer to the debate. Our article analyses the right to housing nowadays, as emerging out of treaties, laws and the international and national case-law. [less ▲]

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See detailImpact of circulation changes on the long-term trend of stratospheric hydrogen fluoride at five NDACC stations
Prignon, Maxime ULg; Bernath, P.F.; Blumenstock, T. et al

Poster (2017, May 29)

Hydrogen fluoride is mainly produced by the photolysis of anthropogenic source gases such as the chlorofluorocarbons (CFC), the hydrochlorofluorocarbons (HCFC) and the hydrofluorocarbons (HFC). These ... [more ▼]

Hydrogen fluoride is mainly produced by the photolysis of anthropogenic source gases such as the chlorofluorocarbons (CFC), the hydrochlorofluorocarbons (HCFC) and the hydrofluorocarbons (HFC). These families of species are known for contributing to ozone depletion and/or to the greenhouse effect. It is thus essential to regulate and monitor their emissions. Despite the fact that the Montreal protocol (1987) has succeeded to reduce and then suppress the CFC emissions, HF is still increasing in the stratosphere because of ongoing emissions of the HCFC and HFC substitution products. In the framework of the recent studies demonstrating the influence of stratospheric circulation changes on the trend of long-lived tracers (e.g. hydrogen chlorine), we decided to investigate the impact of these circulation changes on HF. To achieve this objective, the rates of changes over time of HF total/partial columns at various latitudes of the globe will be determined and critically discussed. Fourier Transform Infrared data produced at five NDACC sites (Kiruna – 68°N, Jungfraujoch – 46°N, Izana – 28°N, Lauder 45°S and Arrival-heights – 78°S) and satellite data (HALOE and ACE) will be used for this study. This preliminary selection of ground-based stations allows to cover both hemispheres and our period of investigation (last two decades). Finally, in order to support our data interpretation, two SLIMCAT simulations (standard and fixed dynamics) will also be included. [less ▲]

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See detailDesign and Management of Freight Transport Networks: Intermodal Transport and Externalities
Mostert, Martine ULg

Doctoral thesis (2017)

Transportation of goods contributes to the economic development of societies but it generates negative impacts on its environment called negative externalities. In its White Paper on Transport, the ... [more ▼]

Transportation of goods contributes to the economic development of societies but it generates negative impacts on its environment called negative externalities. In its White Paper on Transport, the European Commission encourages the flow transfer from road to more environmentally friendly modes like rail or inland waterways (IWW). This objective can be reached by the development of intermodal transport. A literature review on transport externalities and their valorization methods highlights the small number of studies related to the general modeling of transport externalities through dedicated mathematical formulas. However, the latter are important for identifying the key parameters that influence transport competitiveness in terms of externalities. This is demonstrated by analyzing two external cost functions for road and rail. The location of intermodal terminals stands out from the environmental perspective as one of the most important competitiveness factors of intermodal transport regarding road. An innovative mathematical model for the location of terminals and allocation of flows between road and intermodal rail and IWW transport is developed. The model is based on a bi-objective formulation which evaluates the trade-offs between transport operational costs and CO2 emissions. Economies of scale of intermodal transport are integrated. The model is applied to the Belgian network. Results indicate that terminal locations are relatively stable, whatever the optimized economic or environmental objective. The type of terminal located changes according to the followed strategy. Minimizing CO2 emissions leads to an increased use of intermodal transport. The impact of transport on air pollution is also evaluated. On the Belgian case, an economic optimization of transport operational costs is compared to an environmental optimization of transport air pollution external costs. The intervention of public authorities through a taxation policy for trucks is also studied. Results show that the introduction of road taxes leads to a more intensive use of intermodal transport than in the absence of taxes. The maximum intermodal market share is observed when air pollution external costs are minimized. Finally, a new model which considers other intermodal chains than the traditional “road-rail/IWW-road” modeling is applied on experimental data at the European level. The model allows to choose between any direct transport by one mode (road, rail or IWW), and any intermodal transport of up to three modes. Results indicate that several connections may benefit from the use of other combinations of modes than the “road-rail/IWW-road” combination. [less ▲]

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See detailLe Living Lab: une méthode parmi tant d'autres?
Elsen, Catherine ULg

Article for general public (2017)

Cette brève s’inscrit dans une série de publications destinées à partager les expériences et réflexions du WeLL. Ce mois-ci, nous nous attelons à repositionner l’approche Living Lab (son caractère centré ... [more ▼]

Cette brève s’inscrit dans une série de publications destinées à partager les expériences et réflexions du WeLL. Ce mois-ci, nous nous attelons à repositionner l’approche Living Lab (son caractère centré utilisateur, ses méthodes) au sein d’un panorama plus large de nouvelles manières de penser la créativité et l’innovation. En particulier, nous nous intéressons à deux approches complémentaires que sont le Design Thinking et le Creative Problem Solving (ou « C.P.S.»). [less ▲]

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See detail"Je suis retraité et heureux : un paradoxe?"
Grotz, Catherine ULg; Schroyen, Sarah ULg

Conference given outside the academic context (2017)

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See detailPhysiopathologie des tendinopathies
Kaux, Jean-François ULg

Conference (2017, May 28)

Le tendon, tissu conjonctif fibreux, mécaniquement responsable de la transmission de la force des muscles vers les os, constitue une entitédynamique qui, en fonction des contraintes, se restructure en ... [more ▼]

Le tendon, tissu conjonctif fibreux, mécaniquement responsable de la transmission de la force des muscles vers les os, constitue une entitédynamique qui, en fonction des contraintes, se restructure en permanence et, ce, grâce à diverses modifications métaboliques et mécaniques. Cetterevue décrit l’histologie, la vascularisation et l’innervation du tendon sain. De plus, la biomécanique et les réponses physiologiques tendineuses,ainsi que la physiopathologie de la tendinopathie y sont abordées. [less ▲]

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See detailActualités des traitements conservateurs des tendinopathies
Kaux, Jean-François ULg

Conference (2017, May 28)

Les connaissances et la prise en charge des tendinopathies ont beaucoup évolué depuis ces dernières années. En effet, se substituant désormais à l’ancienne appellation « tendinite », les tendinopathies ... [more ▼]

Les connaissances et la prise en charge des tendinopathies ont beaucoup évolué depuis ces dernières années. En effet, se substituant désormais à l’ancienne appellation « tendinite », les tendinopathies sont majoritairement décrites selon le modèle de continuum établi par Cook et Purdam. La compréhension de la physiopathologie de ces lésions a permis l’émergence de nombreux traitements dans le but d’obtenir une récupération optimale et une limitation des récidives. L’objectif de cet article est de faire une revue de l’actualité thérapeutique des tendinopathies. [less ▲]

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See detailEsfera pública discursiva, nº2
Becerra Mayor, David ULg

in Esfera pública discursiva (2017), 2

Número 2 de "Esfera pública discursiva", revista de crítica e información literaria realizada por los estudiantes de "Stylistique et critique de l'espagnol moderne" de la Université de Liège

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See detailIs the arbitrary symmetrical?
Badir, Sémir ULg

in Semiotica (2017)

Arbitrariness is commonly seen as a major concept in Saussure’s thought, and it even receives the status of a “principle” in his theory. It is not only the characteristic feature of the relation between ... [more ▼]

Arbitrariness is commonly seen as a major concept in Saussure’s thought, and it even receives the status of a “principle” in his theory. It is not only the characteristic feature of the relation between the signifier and the signified (the semiological relation is arbitrary), but moreover it is constitutive of this very relation (the relation is semiological because it is arbitrary; there is a so-called “semiological relation” established between a signifier and a signified because of the principle of arbitrariness). And when linguists and other Saussurean interpreters comment on the concept of arbitrariness, they usually imply a binary relation: the semiological relation is arbitrary due to the fact that the signifier is arbitrarily chosen vis-à-vis the signified, and vice versa. I will be questioning the latter assertion in this paper. In my opinion, the symmetry of the semiological relation has not been properly demonstrated. The signifier can be seen as arbitrary with regard to the signified, but no reason has been provided to recognize the converse. Instead a number of arguments can be put forth to see arbitrariness as a concept that implies a non-symmetrical relation. [less ▲]

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See detailAnalyse argumentale : notion d’actant et rôles sémantiques
Winand, Jean ULg

Scientific conference (2017, May 26)

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See detailMorphology of the UV aurorae Jupiter during Juno’s first perijove observations
Bonfond, Bertrand ULg; Gladstone, G. R.; Grodent, Denis ULg et al

in Geophysical Research Letters (2017)

On 27 August 2016, the NASA Juno spacecraft performed its first close-up observations of Jupiter during its perijove. Here we present the UV images and color ratio maps from the Juno-ultraviolet ... [more ▼]

On 27 August 2016, the NASA Juno spacecraft performed its first close-up observations of Jupiter during its perijove. Here we present the UV images and color ratio maps from the Juno-ultraviolet spectrometer UV imaging spectrograph acquired at that time. Data were acquired during four sequences (three in the north, one in the south) from 5:00 UT to 13:00 UT. From these observations, we produced complete maps of the Jovian aurorae, including the nightside. The sequence shows the development of intense outer emission outside the main oval, first in a localized region (255 ∘ –295 ∘ System III longitude) and then all around the pole, followed by a large nightside protrusion of auroral emissions from the main emission into the polar region. Some localized features show signs of differential drift with energy, typical of plasma injections in the middle magnetosphere. Finally, the color-ratio map in the north shows a well-defined area in the polar region possibly linked to the polar cap. [less ▲]

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