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See detailVehicle routing problems with loading constraints: State-of-the-art and future directions
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in OR Spectrum (2015), 37(Issue 2), 297-330

Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring ... [more ▼]

Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring these constraints impairs planning and induces last-minute changes resulting in additional costs. Developing vehicle routing models incorporating loading constraints is critical to more efficient route planning. The last couple of years has seen a huge increase of contributions to this field of research with almost 60 % of these being published after 2009. Our contribution is twofold. First, we overview the recent developments in the literature on all vehicle types in which loading constraints play a key role (trucks, airplanes, ships, and automated guided vehicles), using a state-of-the-art classification scheme to identify the loading constraints considered in each article. Second, we identify research gaps and opportunities for future research. [less ▲]

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See detailA Lower Tournaisian (Hastarian) silicified brachiopod-coral fauna from South Belgium
Denayer, Julien ULg; Mottequin, Bernard; Poty, Edouard

Conference (2015)

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See detailNotions de pharmacologie
Kaux, Jean-François ULg

Learning material (2015)

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See detailA linear accelerator for levitated micro-objects
Sari, Ibrahim; Kraft, Michael ULg

in Sensors and Actuators. A, Physical (2015)

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See detailLa fin du Paléolithique moyen dans le Nord de l’Europe : la question des origines du Lincombien-Ranisien-Jerzmanowicien
Flas, Damien ULg

in Depaepe, Pascal; Goval, Emilie; Koehler, Héloïse (Eds.) et al Les plaines du Nord-Ouest : carrefour de l’Europe au Paléolithique moyen ? (2015)

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See detailLa magie et la sorcellerie des visages comme socle anthropologique de la philosophie sartrienne
Englebert, Jérôme ULg

in Etudes Sartriennes (2015), 17

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à ... [more ▼]

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à un troisième axe, intermédiaire : celui du visage ou, plutôt, des visages. La thèse de ce court essai tient à considérer que la phénoménologie sartrienne a déjà réalisé ce travail de fond qui requiert, pour le rendre explicite, articulation simple et ordonnancement. [less ▲]

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See detailThe anti-angiogenic peptide Anginex blocks osteoclastogenesis
Muller, Joséphine ULg; Binsfeld, Marilène ULg; DUBOIS, Sophie ULg et al

in Belgian Journal of Hematology (2015), Abstracts book

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See detailEditorial. Un regard pluriel sur l’évaluation offert aux scientifiques francophones et construit par eux
Demeuse, Marc; Fagnant, Annick ULg; Dupriez, Vincent

in Evaluer. Journal international de recherche en éducation et formation (2015), 1(1), 5-10

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See detailChapter 4 : Human Exposure of Bisphenol A : Review of the Urinary Levels in the General Population
PIRARD, Catherine ULg; Charlier, Corinne ULg

in Gibert, Yann (Ed.) Bisphenol A : Sources, Risks of Environmental Exposure and Human Health Effects (2015)

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See detailRegional volumes and spatial volumetric distribution of gray matter in the gender dysphoric brain.
Hoekzema, Elseline; Schagen, Sebastian E. E.; Kreukels, Baudewijntje P. C. et al

in Psychoneuroendocrinology (2015), 55C

The sexual differentiation of the brain is primarily driven by gonadal hormones during fetal development. Leading theories on the etiology of gender dysphoria (GD) involve deviations herein. To examine ... [more ▼]

The sexual differentiation of the brain is primarily driven by gonadal hormones during fetal development. Leading theories on the etiology of gender dysphoria (GD) involve deviations herein. To examine whether there are signs of a sex-atypical brain development in GD, we quantified regional neural gray matter (GM) volumes in 55 female-to-male and 38 male-to-female adolescents, 44 boys and 52 girls without GD and applied both univariate and multivariate analyses. In girls, more GM volume was observed in the left superior medial frontal cortex, while boys had more volume in the bilateral superior posterior hemispheres of the cerebellum and the hypothalamus. Regarding the GD groups, at whole-brain level they differed only from individuals sharing their gender identity but not from their natal sex. Accordingly, using multivariate pattern recognition analyses, the GD groups could more accurately be automatically discriminated from individuals sharing their gender identity than those sharing their natal sex based on spatially distributed GM patterns. However, region of interest analyses indicated less GM volume in the right cerebellum and more volume in the medial frontal cortex in female-to-males in comparison to girls without GD, while male-to-females had less volume in the bilateral cerebellum and hypothalamus than natal boys. Deviations from the natal sex within sexually dimorphic structures were also observed in the untreated subsamples. Our findings thus indicate that GM distribution and regional volumes in GD adolescents are largely in accordance with their respective natal sex. However, there are subtle deviations from the natal sex in sexually dimorphic structures, which can represent signs of a partial sex-atypical differentiation of the brain. [less ▲]

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See detailThe ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating patterning of prethalamus and ventral telencephalon.
Magnani, D; Morlé, L; Hasenpusch-Theil, K et al

in Human Molecular Genetics (2015)

Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of ... [more ▼]

Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of primary cilia underlie a large number of human syndromes collectively referred to as ciliopathies. Often, ciliopathies are associated with mental retardation (MR) and malformation of the corpus callosum. However, the possibility of defects in other forebrain axon tracts, which could contribute to the cognitive disorders of these patients, has not been explored. Here, we investigate the formation of the corticothalamic/thalamocortical tracts in mice mutant for Rfx3, which regulates the expression of many genes involved in ciliogenesis and cilia function. Using DiI axon tracing and immunohistochemistry experiments, we show that some Rfx3-/- corticothalamic axons abnormally migrate toward the pial surface of the ventral telencephalon (VT). Some thalamocortical axons (TCAs) also fail to leave the diencephalon or abnormally project toward the amygdala. Moreover, the Rfx3-/- VT displays heterotopias containing attractive guidance cues and expressing the guidance molecules Slit1 and Netrin1. Finally, the abnormal projection of TCAs toward the amygdala is also present in mice carrying a mutation in the Inpp5e gene, which is mutated in Joubert Syndrome and which controls cilia signaling and stability. The presence of identical thalamocortical malformations in two independent ciliary mutants indicates a novel role for primary cilia in the formation of the corticothalamic/thalamocortical tracts by establishing the correct cellular environment necessary for its development. [less ▲]

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See detailMethods to Assess the Activation of the Alternative (Noncanonical) NF-kappaB Pathway by Non-death TNF Receptors.
Remouchamps, Caroline ULg; Dejardin, Emmanuel ULg

in NF-kappa B: Methods and Protocols (2015)

The alternative or noncanonical NF-kappaB pathway regulates the generation of p52-containing NF-kappaB dimers (e.g., p52/RelB) through a partial degradation (called processing) of the precursor p100 into ... [more ▼]

The alternative or noncanonical NF-kappaB pathway regulates the generation of p52-containing NF-kappaB dimers (e.g., p52/RelB) through a partial degradation (called processing) of the precursor p100 into p52. This pathway is activated by a subset of non-death TNF receptor members, which ultimately activate two kinases: NIK (NF-kappaB-Inducing Kinase) and IKKalpha (Inhibitor of kappaB Kinase alpha). These kinases create a phosphodegron for the E3 ligase SCF-beta-TrCP that covalently binds K48-linked polyubiquitin chain onto p100 prior to its proteasomal processing. The resulting p52-containing complexes translocate into the nucleus to activate target genes involved in secondary lymphoid organ development, B cell survival or in osteoclastogenesis.We describe in this chapter straightforward methods to monitor the activation of the alternative NF-kappaB pathway. These methods uncover cytosolic and nuclear biochemical modifications of key proteins of the alternative NF-kappaB pathway required prior to the transcription of NF-kappaB target genes. [less ▲]

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See detailLe Journal d’Antoine Galland (1646-1715) : la période parisienne. Volume IV (1714-1715)
Bauden, Frédéric ULg; Waller, Richard; Veymiers, Richard ULg et al

Book published by Peeters (2015)

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See detailLe Journal d’Antoine Galland (1646-1715) : la période parisienne. Volume III (1712-1713)
Bauden, Frédéric ULg; Waller, Richard; Veymiers, Richard ULg et al

Book published by Peeters (2015)

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See detailNew data on the recent history of the littoral forests of southern Cameroon: an insight into the role of historical human disturbances on the current forest composition
Biwolé, Achille ULg; Morin-Rivat, Julie ULg; Fayolle, Adeline ULg et al

in Plant Ecology and Evolution (2015), 148(1), 19-28

Background and aims – Prior to European colonisation of Central Africa, human populations were dispersed through the forests, where they practiced slash-and-burn cultivation. From the 19th century they ... [more ▼]

Background and aims – Prior to European colonisation of Central Africa, human populations were dispersed through the forests, where they practiced slash-and-burn cultivation. From the 19th century they were progressively concentrated in villages along roads, leaving large areas of forest derelict. In south-western Cameroon, and elsewhere in Central Africa, forest canopy is dominated by long-lived lightdemanding tree species, suggesting a possible role of human disturbance. The aim of this study was to bring new insights into the possible effect of historical human disturbances in terms of timing and spatial extent on the current forest composition. Location – Wet evergreen littoral forest in south-western Cameroon. Methods and key results – A combined vegetation sampling and archaeobotanical survey were conducted. Potsherds, oil-palm endocarps, and charcoal were found throughout the study area, suggesting generalised human occupation and anthropogenic fire. Human occupancy occurred in two periods: between 2200 and 1500 BP, and, more recently, beginning three centuries ago. High frequency of fire and the presence of Elaeis guineensis both dated recently (between 260 and 145 BP) suggest slash-and-burn shifting cultivation practices. These human-induced disturbances may coincide with the age of the current emergent lightdemanding species, the age of which can be estimated around 200 years, or with the phases of drying climate recorded in the Central African forest in the early 18th century. Conclusions – These results support the idea that historical human disturbances are one of the major factors that shaped the current forest composition in Central Africa. [less ▲]

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See detailApplication of random eigenvalue analysis to assess bridge flutter probability
Canor, Thomas; Caracoglia, Luca; Denoël, Vincent ULg

in Journal of Wind Engineering and Industrial Aerodynamics (2015), 140(0), 79--86

Abstract This study examines the well-known issue of evaluating the flutter probability for a long-span bridge, necessary for assessing structural integrity and reliability. The motivation stems from the ... [more ▼]

Abstract This study examines the well-known issue of evaluating the flutter probability for a long-span bridge, necessary for assessing structural integrity and reliability. The motivation stems from the need for critically reviewing and investigating a number of existing numerical approaches (e.g., random perturbation analysis, collocation methods, Galerkin approach) for the modeling and the solution of stochastic dynamic problems, by adapting them to the specific problem. The study proposes a generalized formulation for stochastic bridge flutter in terms of random eigenvalue analysis. A 1200 m suspension bridge model is used in the numerical simulations to compare the various methods and to provide indications on advantages and limitations of each method. Moreover, the link between the proposed formulation and existing studies on the propagation of uncertainty in aeroelastic systems, for example associated with measurement errors in wind tunnel, is examined. [less ▲]

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See detailMultiple timescale spectral analysis
Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2015), 39(0), 69--86

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the ... [more ▼]

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the steady-state second order cumulant of a linear oscillator, under the action of a stationary loading prescribed by means of its power spectral density. There exists however a broad variety of such similar problems, extending the concept to multi degree-of-freedom systems, non Gaussian excitation, slightly nonlinear oscillators or even transient excitations. In this wide class of problems, the cumulants of the response are obtained as the result of the integral of corresponding spectra over the frequency space, which is possibly multidimensional. Application of standard numerical integration techniques may be prohibitive, a reason why the spectral approach is often left aside. Besides, many engineering problems involve a clear timescale separation, usually of those pertaining to the loading and to the mechanical behavior of the system. In these problems, a proper consideration of the timescale separation results in dropping the order of integration by one, at least. This offers the possibility to derive analytical solutions, whenever the order of integration drops to zero, or to make numerical integration competitive. The paper presents this general method, together with some applications in wind and marine engineering. [less ▲]

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See detailLes vers à soie sauvages à Madagascar : Enjeux écologiques et socio-économiques
Verheggen, François ULg; Haubruge, Eric ULg; Bogaert, Jan ULg

in Entomologie Faunistique = Faunistic Entomology (2015), 68

We here introduce the book « The Malagasy silk moths: ecological and socio-economic challenges » published in 2013 by the Presses agronomiques de Gembloux (Belgium). This book reflects the achievements ... [more ▼]

We here introduce the book « The Malagasy silk moths: ecological and socio-economic challenges » published in 2013 by the Presses agronomiques de Gembloux (Belgium). This book reflects the achievements and scientific activities of the project "Sustainable Management and valorisation of the endemic silkworm Borocera cajani in forest areas in the Antananarivo region" funded by Commission universitaire pour le Développement (CUD - CIUF). [less ▲]

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See detailLe Code de droit économique: présentation générale
Thirion, Nicolas ULg

in Thirion, Nicolas (Ed.) Le Code de droit économique: principales innovations (2015)