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See detailLaser Cladding of High Speed Steel Deposits : Thermal history - Microstructure - Wear Behaviour
Mertens, Anne ULiege

Learning material (2017)

This powerpoint presentation was used as teaching material in a seminar given as part of the course “Advanced Manufacturing technologies” at Université catholique de Louvain. It outlines important current ... [more ▼]

This powerpoint presentation was used as teaching material in a seminar given as part of the course “Advanced Manufacturing technologies” at Université catholique de Louvain. It outlines important current issues in the development of additive technologies for the processing of metallic materials through a case study on the laser cladding of high speed steels. A particular attention was given to the role of local variation in thermal history in controlling the microstructure and the wear resistance of thick high speed steels deposits. [less ▲]

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See detailBulk superconducting tube subjected to the stray magnetic field of a solenoid
Hogan, Kevin ULiege; Fagnard, Jean-François ULiege; Wera, Laurent ULiege et al

in Superconductor Science and Technology (2017), 31(1),

Hard type-II hollow superconductors are well suited for low frequency magnetic shielding. The properties and performances of superconducting magnetic shields subjected to homogeneous magnetic fields have ... [more ▼]

Hard type-II hollow superconductors are well suited for low frequency magnetic shielding. The properties and performances of superconducting magnetic shields subjected to homogeneous magnetic fields have been extensively discussed in the literature. In the present work, we investigate the magnetic shielding and the penetration of magnetic flux in a bulk high temperature superconducting tube subjected to the inhomogeneous fringe field of a solenoidal coil. Thanks to a bespoke microdisplacement measurement system, we measure the magnetic field distribution around the tube. We develop a full 3D finite element model based on an H formulation to understand the flux penetration mechanisms and predict the shape of the current loops. Using constitutive law parameters obtained from previous independent experiments, our model is found to be in excellent agreement with the measurements. We discuss how to assess the degree of inhomogeneity of the magnetic field and show that, in our case study, the field can be treated as the magnetic field of an equivalent magnetic dipole. We also show that some features of the flux penetration in inhomogeneous field can be also observed when the tube is subjected to an oblique homogeneous magnetic field, which offers a better understanding of the shielding current density distribution inside the shield. Finally, we discuss the magnetic field concentration occurring around the shield for different magnetic field configurations. In particular, we show that the extremities of the tube on the side not facing the magnetic field source experience the highest flux concentration. [less ▲]

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See detailUnique alternating peptide-peptoid copolymers from dipeptides via Ugi reaction in water
Al Samad, Assala ULiege; De Winter, Julien; Gergaux, Pascal et al

in Chemical Communications (2017), 53(90), 12240-12243

Herein, we developed a strainghtforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid ... [more ▼]

Herein, we developed a strainghtforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid copolymers as well as block copolymers were produced in a single step in the presence of acrylic acid and carboxylic acid-terminated poly(ethylene glycol). The thermoresponsiveness of these polymers is highlighted [less ▲]

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See detailÀ quelle discipline appartiennent les enfants ? Croisements, échanges et reconfigurations de la recherche autour de l'enfance
Pirard, Florence ULiege

Scientific conference (2017, November 21)

Notre communication prend la forme d'une participation à une table ronde centrée sur la discussion d'un ouvrage consacré aux usages de l'interdisciplinarité dans la recherche autour de l'enfance. Elle ... [more ▼]

Notre communication prend la forme d'une participation à une table ronde centrée sur la discussion d'un ouvrage consacré aux usages de l'interdisciplinarité dans la recherche autour de l'enfance. Elle souligne la complexité de ce type de démarche qui nécessite un « travail d’équilibriste » entre les langages, les choix épistémologiques, théoriques et méthodologiques des uns et des autres. [less ▲]

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See detailSartre en radio
Cormann, Grégory ULiege; Hamers, Jérémy ULiege

Scientific conference (2017, November 21)

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See detailState Aid law in the European Union - the issue of tax rulings
Van Cleynenbreugel, Pieter ULiege

Speech/Talk (2017)

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See detailHorizontal integration under yardstick competition
Teusch, Jonas ULiege

Doctoral thesis (2017)

Horizontal integration through mergers and cross-ownership is ubiquitous; industries regulated by yardstick competition are no exception in this regard. However, even though yardstick competition is ... [more ▼]

Horizontal integration through mergers and cross-ownership is ubiquitous; industries regulated by yardstick competition are no exception in this regard. However, even though yardstick competition is applied to sectors of vital economic importance, such as energy and water networks, the welfare effects of horizontal integration in these settings have largely escaped scientific scrutiny. The dissertation therefore studies the welfare implications of horizontal integration under yardstick competition and identifies potential trade-offs. Specifically, whereas mergers and cross-ownership may bring about efficiency gains, there is a possibility that horizontal integration simultaneously decreases the effectiveness of regulation, benefiting certain firms at the expense of consumers and competitors. Key conditions for such strategic effects to occur and to dominate efficiency effects are derived in a principal-agent model. The thesis also demonstrates that the issue is not merely of academic interest, but has affected the practical application of yardstick competition in the electricity distribution industries of both Belgium and Norway. Chapter 1 analyses how horizontal mergers, joint ventures and regulatory decentralisation complicate the application of yardstick competition in Belgian electricity distribution. Chapter 2 develops a theoretical model of mergers under yardstick competition - formalising the welfare trade-offs at the heart of this dissertation. Chapter 3 leverages Data Envelopment Analysis to quantify both efficiency and strategic effects of horizontal restructuring in Norwegian electricity distribution and points to a recent merger that appears to have been driven by strategic motivations. Chapter 4 uses several econometric identification strategies - dynamic regression, matching on observables and instrumental variables - to establish that between 2007 and 2015, cross-ownership increased firm performance in Norwegian electricity distribution, which suggests that the net welfare effects were positive in this application. [less ▲]

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See detailLE PARTENARIAT PUBLIC-PRIVE (PPP) EST-IL UN MODE DE COLLABORATION POUR REUSSIR L’ARGANICULTURE AU MAROC ?
Maatala, Nassreddine ULiege; Chati, Mohammed Taoufiq

Conference (2017, November 21)

The production of quality plants that adapt to severe water conditions and resist cryptogrammic attacks remains a necessary step for the development of the argane culture. In this context, the Public ... [more ▼]

The production of quality plants that adapt to severe water conditions and resist cryptogrammic attacks remains a necessary step for the development of the argane culture. In this context, the Public-Private Partnership (PPP) can be a way of collaboration to cope with this technical constraint by ensuring the highest quality plants and to promote investment and implementation projects. Indeed, risk sharing, considered the core of PPPs, can encourage private investors to make efforts to domesticate the Argane culture. The objective of this paper is to propose an analysis of the production system of arganiculture and propose a mode of public-private partnership in order to increase the success rate of the various projects of argane culture. [less ▲]

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See detailLa digitalisation du droit: représentations, accessibilité, mutations
Dubois, Christophe ULiege

Scientific conference (2017, November 21)

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See detailLes "maladies rares" en Belgique : Processus de co-construction d'un objet-frontière
Duysens, Fanny ULiege

Conference (2017, November 20)

La présentation a retracé l'évolution de la catégorie "maladies rares" à l'échelle internationale puis nationale, telle qu'elle se donne à observer aujourd'hui sur le terrain de la Belgique, tout en ... [more ▼]

La présentation a retracé l'évolution de la catégorie "maladies rares" à l'échelle internationale puis nationale, telle qu'elle se donne à observer aujourd'hui sur le terrain de la Belgique, tout en soulevant certains enjeux et défis relatifs aux processus de co-construction dont elle fait l'objet dans les rapports entre les multiples acteurs impliqués. En outre, dans le cadre de cette journée d’étude interdisciplinaire, la présentation visait à croiser les observations empiriques avec des réflexions épistémologiques et méthodologiques relatives aux pratiques de recherche en sciences sociales. Il s'agissait d'expliciter l'approche mise en œuvre pour étudier l'objet "maladies rares" : comment le suivre, le construire, puis le restituer dans l’analyse ? [less ▲]

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See detailChangement climatique et dynamique migratoire
Ozer, Pierre ULiege

Conference given outside the academic context (2017)

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See detailA Methodology to Determine the Potential of Urban Densification through Roof Stacking
Amer, Mohamed ULiege; Mustafa, Ahmed; Teller, Jacques ULiege et al

in Sustainable Cities and Society (2017), 35

Facing the need to accommodate a growing number of inhabitants in major European cities, this research aimed to establish a methodology that facilitates decision making on urban densification through roof ... [more ▼]

Facing the need to accommodate a growing number of inhabitants in major European cities, this research aimed to establish a methodology that facilitates decision making on urban densification through roof stacking. The methodology adopts a systematic approach on three consecutive levels: urban, engineering, and social. Multiple criteria are identified to assess and map the roof stacking potential in terms of location and number of added floors. The Brussels Capital Region was chosen as a case study to experiment with the developed workflow chart and validate the proposed approach, using ArcGIS software, by creating a map of the urban densification potential through roof stacking of Brussels at the city scale. The results show a realistic potential of accommodating 30% of the expected population increase in Brussels by the year 2040 using only roof stacking, provided that the current urban regulations are respected. In addition, a theoretical potential to accommodate more than the expected population increase by the same year is proposed provided that urban planning regulations are relaxed in relation to the height of buildings. Further applications to other cities in Europe would help create additional opportunities to develop an automated tool for estimating such potentials on a wider scope. [less ▲]

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See detailIn silico modeling of bone formation under the influence of calcium phosphate-based biomaterials and osteochondrogenic growth factors
Manhas, Varun ULiege

Doctoral thesis (2017)

Bone regeneration is a complex process that involves regulation of different cell types by multiple biochemical, physical and mechanical factors. Unlike other biological tissues, bone can heal scarlessly ... [more ▼]

Bone regeneration is a complex process that involves regulation of different cell types by multiple biochemical, physical and mechanical factors. Unlike other biological tissues, bone can heal scarlessly and recover its original shape, size and strength. However, about 5% of bone defects result in non-unions. To tackle these non-unions, tissue engineering (TE) aims to develop bone substitutes or intelligent TE constructs to replace damaged, diseased or aging tissue. These bone substitutes/TE constructs are designed to support the chemotaxis, proliferation and differentiation of bone progenitor cells as well as being a biochemical agent delivery system. However, these delivery systems have a few limitations such as structural weakness of the carrier, high doses of biochemical agents being delivered due to burst release, unknown optimal concentrations of implanted cells and their high cost. Another drawback of these systems is the limited understanding on the relationship between biochemical agent dose, implanted cells, carrier volume, carrier material type and resultant bone formation. Given their significant medical potential, there is an increasing demand to design and develop improved bone substitutes/TE constructs. This PhD work fits in the long-term vision that mathematical models can be used as a part of design and manufacturing processes to develop improved treatment strategies and ultimately save experimental time and costs. In the first part of this work, a novel computational model was developed to predict the in vitro release of Ca2+ ions from calcium phosphate (CaP)-based scaffolds. The developed model was based on the Noyes-Whitney equation, the Fick’s second law of diffusion equation and the level-set method (LSM). The model was dependent on biophysicochemical phenomena such as dissolution, diffusion and degradation along with specific scaffold characteristics such as composition, size and shape. The predictions of the model were compared to dedicated experimental results. In the second part of this work, we investigated the use of a previously reported oxygen-dependent fracture healing model to elucidate the in vivo bone formation capacity of bone morphogenetic protein-2 (BMP-2) delivery systems in an ectopic environment. Specific attention was paid to the influence of BMP-2 dose and carrier volume on ectopic bone formation. The performance of this mathematical model was corroborated by comparison with experimental results published in the literature. Finally, the model was applied to investigate the influence of different BMP-2 release profiles on ectopic bone formation. In the third part of this work, we developed a novel computational model to predict the CaP and BMP-dependent ectopic bone formation in nude mice with and without incorporation of donor cells. The model specifically investigated the influence of BMP-2 dose, donor cell concentrations and calcium ion release on ectopic bone formation. The performance of this mathematical model was compared to the results of dedicated in-house experiments. The model was able to capture essential elements of the experimental results yet at the same time, a number of points for further improvement were identified. In the final part of this work, we investigated the application of the aforementioned CaP and BMP-dependent bone formation model to an orthotopic setting in sheep. The performance of the mathematical model was corroborated by comparing the model predictions with experimental results published in the literature. Subsequently, the model was applied to investigate the influence of different CaP-BMP-cell combinations on orthotopic bone formation, simulating in-house ongoing experiments. In conclusion, this PhD work illustrates a computational step taken towards enhancing the understanding on the role of CaP and BMPs in healing large bone defects. [less ▲]

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See detailA Genome Mining Toolbox for CRISPR-associated Cas9 orthologues
Golestan Hashemi, Farahnaz Sadat ULiege

Scientific conference (2017, November 20)

CRISPR-associated protein system can facilitate accurate and targeted editing of genomes. RNAguided Cas9 can be employed as an efficient genome editing tool in human, plants, and animals.The Cas9 nuclease ... [more ▼]

CRISPR-associated protein system can facilitate accurate and targeted editing of genomes. RNAguided Cas9 can be employed as an efficient genome editing tool in human, plants, and animals.The Cas9 nuclease can be programmed by guide RNA (GRNA) in order to cut DNA at targetedregions. Therefore, concise mutations are introduced bY homologous recombination or non- homologous end-joining repairing. Although the CRISPR / Cas9 is a powerful system, alternativestrategies have been developed to decrease the risk of off-target activities such as using Cas9orthologs. Additionally, only one activity can be mediated by the Cas9 protein fromStreptococcus pyogenes (Sp) at different target regions. In other words, it is unable tosimultaneously mediate a different activityY at other targets. Besides SpCas9, some orthologousCRISPR-Cas9 systems from different species have been discovered and utilized for genomeediting. Therefore, in order for wider application of CRISPR-Case, new and applicable Casproteins, with different requirements for PAM sequence, gRNA length, and tracrRNA and crRNA1 sequences, have nameged from several species as a new tool for effective genome editing.Consequently, discovery of various potential Cas9 proteins becomes a major concern forCRISPR/Cas-mediated genome editing technology to develop straightforward bioinformaticstools with high ifficiencY and versatility to facilitate the artificial design of possible gRNAs.Hence, we aimed to create an application tool to perform high-throughput detection of targetsites based on the specific sequence and length of PAM followed by a constant length of targetsite for not only common Streptococcus pyogenes (SpCas9) but also for other CRISPR-Cassystems. To this end, different search modes for gRNA detection were applied including i)coding strand searching, ii) anti-coding strand searching, iii) both strand searching. Also, acomplete list of all possible gRNAs along with their useful information can be provided forvarious potential Cas9 orthologs. Such progress expands the toolbox of genome editing and thepossibilities for the site-specific genome engineering. [less ▲]

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See detailLes structures sémiotiques dans le croisement football-publicité
Bassilua Nzuzi, Anicet ULiege

in Estudos Semióticos (2017), v. 13(2017),

La production du sens dans l’interaction est un des domaines vers lequel s’orientent aujourd’hui beaucoup de recherches en sémiotique. Il suffit, pour cela, de considérer par exemple les récents travaux ... [more ▼]

La production du sens dans l’interaction est un des domaines vers lequel s’orientent aujourd’hui beaucoup de recherches en sémiotique. Il suffit, pour cela, de considérer par exemple les récents travaux d’Eric Landowski, d’Erik Bertin et d’autres encore, lesquels, en revisitant certaines notions comme la narrativité ou la discursivité, s’emploient à construire de nouveaux modèles sémiotiques, capables de rendre plus adéquatement compte de cette réalité. Dans les situations d’interaction, des grandeurs provenant de diverses entités qui interagissent se croisent en suivant quelques régimes possibles. Notre texte, qui examine le croisement du football avec la publicité, repère au moins deux de ces régimes, très liés : la programmation et l’ajustement, grâce auxquelles les unités de ces deux ensembles réalisent leur mise en commun au stade. Ces régimes produisent du sens en suivant des parcours spécifiques que nous identifions à travers les structures de significations qu’ils mettent en oeuvre. Notre texte, qui voudrait examiner l’héritage du structuralisme dans les études contemporaines, montre que l’étude des structures peut encore servir à l’examen de la production du sens, du moins dans les pratiques contemporaines dans lesquelles nous classons le croisement du football avec la publicité. [less ▲]

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See detailLa mystification
Stienon, Valérie ULiege

Conference (2017, November 20)

Examen des acceptions historiques, des usages conceptuels et des mécanismes du rire de mystification, appuyé sur des exemples empruntés aux XIXe-XXIe siècles et à différents médias: histoire du livre ... [more ▼]

Examen des acceptions historiques, des usages conceptuels et des mécanismes du rire de mystification, appuyé sur des exemples empruntés aux XIXe-XXIe siècles et à différents médias: histoire du livre, spectacle télévisuel, émission radiophonique et fiction cinématographique. [less ▲]

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See detail“A Genome Mining Toolbox for CRISPR-associated Cas9 orthologues”
Golestan Hashemi, Farahnaz Sadat ULiege

Scientific conference (2017, November 19)

CRISPR-associated protein system can facilitate accurate and targeted editing of genomes. RNA-guided Cas9 can be employed as an efficient genome editing tool in human, plants, and animals. The Cas9 ... [more ▼]

CRISPR-associated protein system can facilitate accurate and targeted editing of genomes. RNA-guided Cas9 can be employed as an efficient genome editing tool in human, plants, and animals. The Cas9 nuclease can be programmed by guide RNA (gRNA) in order to cut DNA at targeted regions. Therefore, concise mutations are introduced by homologous recombination or non-homologous end-joining repairing. Although the CRISPR/Cas9 is a powerful system, alternative strategies have been developed to decrease the risk of off-target activities such as using Cas9 orthologs. Additionally, only one activity can be mediated by the Cas9 protein from Streptococcus pyogenes (Sp) at different target regions. In other words, it is unable to simultaneously mediate a different activity at other targets. Besides SpCas9, some orthologous CRISPR–Cas9 systems from different species have been discovered and utilized for genome editing. Therefore, in order for wider application of CRISPR-Cas, new and applicable Cas proteins, with different requirements for PAM sequence, gRNA length, and tracrRNA and crRNA sequences, have emerged from several species as a new tool for effective genome editing. Consequently, discovery of various potential Cas9 proteins becomes a major concern for CRISPR/Cas-mediated genome editing technology to develop straightforward bioinformatics tools with high efficiency and versatility to facilitate the artificial design of possible gRNAs. Hence, we aimed to create an application tool to perform high-throughput detection of target sites based on the specific sequence and length of PAM followed by a constant length of target site for not only common Streptococcus pyogenes (SpCas9) but also for other CRISPR-Cas systems. To this end, different search modes for gRNA detection were applied including i) coding strand searching, ii) anti-coding strand searching, iii) both strand searching. Also, a complete list of all possible gRNAs along with their useful information can be provided for various potential Cas9 orthologs. Such progress expands the toolbox of genome editing and the possibilities for the site-specific genome engineering. [less ▲]

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See detailLes biais attentionnels envers l’alcool chez les « petits consommateurs » vs « gros consommateurs » dans un environnement virtuel
Pollet, Hélène; Quertemont, Etienne ULiege; Bouchard, Stéphane et al

Poster (2017, November 18)

Introduction : Les personnes dépendantes à l'alcool montrent des biais attentionnels quand elles sont confrontées à des indices liés à l’alcool (Kreusch, Vilenne, & Quertemont, 2013). D’après le modèle de ... [more ▼]

Introduction : Les personnes dépendantes à l'alcool montrent des biais attentionnels quand elles sont confrontées à des indices liés à l’alcool (Kreusch, Vilenne, & Quertemont, 2013). D’après le modèle de Wiers et al. (2007), les biais attentionnels favoriseraient la consommation répétée de substances. Objectif : Cette étude exploratoire évalue dans quelle mesure la réalité virtuelle fournit un environnement permettant de tester ces biais attentionnels. Hypothèse : Les gros consommateurs d'alcool présentent des biais attentionnels plus fréquents et plus intenses que les petits consommateurs. Méthode : Un questionnaire en ligne permettant de recruter 24 petits et 24 gros consommateurs d’alcool a d’abord été administré afin de présélectionner les sujets. Les participants ont ensuite réalisé une tâche d’immersion dans un environnement virtuel de « bar ». Le nombre de zooms effectués sur les stimuli « bières » et le nombre de commentaires rapportés en lien avec l’alcool étaient mesurés. Directement après l’immersion, la Visual Analogue Craving Scale (VAS) leur était administrée afin d’évaluer leur envie de boire. Résultats : Les « gros consommateurs » présentent davantage de zooms sur les stimuli « bières » que les «petits consommateurs». De plus, les « gros consommateurs » présentent un score plus élevé à la VAS que les «petits consommateurs », ce qui témoignerait d’une envie de consommer plus élevée après l’immersion par rapport aux « petits consommateurs ». Cependant, aucune corrélation significative n’a été mise en avant entre le nombre de zooms effectués et le score à la VAS chez les « gros consommateurs ». Conclusion : En accord avec nos hypothèses, nos résultats ont montré que les gros consommateurs présentent davantage de biais attentionnels envers les stimuli liés à l’alcool que les petits consommateurs ». Cependant, de futures recherches sont nécessaires afin de pouvoir confirmer que la réalité virtuelle fournit un environnement qui permet de tester les biais attentionnels. [less ▲]

Detailed reference viewed: 27 (1 ULiège)