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See detailDes chiffres de la politique à la politique du chiffre Le cas des réformes du financement de la recherche dans les universités belge francophones.
Fallon, Catherine ULg

in Reflets et Perspectives de la Vie Economique (2015)

“Governing by numbers” is a trend on the increase in public action. Numbers tend to pervade the politico-administrative space without questioning neither the quantification processes which produce them ... [more ▼]

“Governing by numbers” is a trend on the increase in public action. Numbers tend to pervade the politico-administrative space without questioning neither the quantification processes which produce them nor the conditions of their utilization in government. And yet the use of numbers and data in political arguments contribute to transform the terms of the debate: politics can transform data and indicators, but one should not neglect how numbers affect policymaking. This article proposes as case study the analysis of some recent transformations of public research funding mechanism in universities in French speaking Belgium. It questions the systemic effects of the use of performance indicators in public management in this sector and it proposes some starting points for a discussion of their impact on the quality of the political debate. [less ▲]

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See detailComplete analytical procedure to assess the response of a frame submitted to a column loss
Huvelle, Clara; Hoang, Van Long ULg; Jaspart, Jean-Pierre ULg et al

in Engineering Structures (2015), 86

The present paper gives a global overview on recent developments performed at the University of Liege on structural robustness of buildings for the specific scenario ‘‘loss of a column’’. In particular, a ... [more ▼]

The present paper gives a global overview on recent developments performed at the University of Liege on structural robustness of buildings for the specific scenario ‘‘loss of a column’’. In particular, a complete analytical method to assess the response of a 2D frame losing statically one of its columns is presented in details. This method is based on the development of alternative load paths in the damaged structure and takes into account the couplings between the different parts of the structure which are differently affected by the column loss. Also, the validation of the developed method through comparison to experimental and numerical evidences is presented. [less ▲]

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See detailConcept et perception. Le conceptualisme en question
Gauvry, Charlotte ULg; Brisart, Robert

Book published by Olms (2015)

Introduction et traductions de textes de Bill Brewer, Tim Crane, Fred Dretske, Gareth Evans, John McDowell, Christopher Peacocke, Charles Travis et Michael Tye. Par une introduction détaillée et une ... [more ▼]

Introduction et traductions de textes de Bill Brewer, Tim Crane, Fred Dretske, Gareth Evans, John McDowell, Christopher Peacocke, Charles Travis et Michael Tye. Par une introduction détaillée et une sélection de neuf textes emblématiques traduits en français, l’enjeu de ce volume est d’introduire le lecteur francophone à l’histoire de la controverse sur le contenu conceptuel de la perception et de lui en proposer une fine compréhension par l’analyse des différents arguments mobilisés dans les deux camps. Simultanément, le volume a pour ambition de tester la longévité de ces arguments et d’interroger la place qui est dévolue à la controverse sur la scène philosophique la plus contemporaine. [less ▲]

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See detailCompte rendu de 'Mutations et déterminisme chez Bourdieu'
Saint-Amand, Denis ULg

in Lectures (2015)

En définitive, il aurait sans doute mieux valu resserrer le propos sous la forme d’un article critique qui aurait pu trouver place dans une revue spécialisée : ne se donnant par les moyens de ses trop ... [more ▼]

En définitive, il aurait sans doute mieux valu resserrer le propos sous la forme d’un article critique qui aurait pu trouver place dans une revue spécialisée : ne se donnant par les moyens de ses trop hautes ambitions, l’ouvrage se révèle trop léger en plus de se distinguer par le manque de soin apporté à sa réalisation [less ▲]

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See detailPrincipes biomécaniques pour le sport (cours ADEPS)
Schwartz, Cédric ULg

Learning material (2015)

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See detailSignes et corrections dans le P.Vat. gr. 11v - Favorinos, De exsilio
Macedo, Gabriel ULg

in Marganne, Marie-Hélène; Amato, Eugenio (Eds.) Entre papyrologie, philologie et littérature. Autour du traité "Sur l'Exil" de Favorinos d'Arles. Actes de la journée d'études, Nantes 13-11-2013 (2015)

A study of scribal practices, signs and corrections on the only known copy of Favorinos' De exsilio.

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See detailUncertainties in Models of Stellar Structure and Evolution
Noels-Grötsch, Arlette ULg; Bragaglia, Angela

in Astrophysics and Space Science Proceedings (2015), 39

Numerous physical aspects of stellar physics have been presented in Session 2 and the underlying uncertainties have been tentatively assessed. We try here to highlight some specific points raised after ... [more ▼]

Numerous physical aspects of stellar physics have been presented in Session 2 and the underlying uncertainties have been tentatively assessed. We try here to highlight some specific points raised after the talks and during the general discussion at the end of the session and eventually at the end of the workshop. A table of model uncertainties is then drawn with the help of the participants in order to give the state of the art in stellar modeling uncertainties as of July 2013. [less ▲]

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See detailLes techniques de restauration des prairies tempérées fonctionnent-elles sous les tropiques ?
Le Stradic, Soizig ULg; Buisson, Elise

in Forget, Michel-Pierre; Hossaert-McKey, Martine; Poncy, Odile (Eds.) Écologie tropicale: De l'ombre à la lumière (2015)

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See detailNeuromodulation in migraine: state of the art and perspectives.
MAGIS, Delphine ULg

in Expert review of medical devices (2015)

Migraine is a highly prevalent and disabling disease. The drugs prescribed for migraine prophylaxis can have intolerable side effects or can be ineffective. Neuromodulation techniques are increasingly ... [more ▼]

Migraine is a highly prevalent and disabling disease. The drugs prescribed for migraine prophylaxis can have intolerable side effects or can be ineffective. Neuromodulation techniques are increasingly used in neurology. Transcutaneous supraorbital nerve stimulation is effective in episodic migraine prevention, whereas vagus nerve stimulation provides interesting results in acute migraine therapy. Transcranial stimulation techniques gave variable, and sometimes contradictory, results. The visual cortex is the target of choice in migraine: studies in migraine prevention and aura acute treatment are encouraging. These noninvasive therapies appear safe with a low rate of side effects. Available studies of invasive occipital nerve stimulation in chronic migraine gave modest results; but invasive occipital nerve stimulation offers a new hope to highly disabled patients who failed to respond to any other treatment. In the future, neuromodulation will probably take an increasing place in migraine treatment, as add-on therapy or alternative to medications, especially because of its attractive safety profile. [less ▲]

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See detailConstructing Quebec and Wallonia: How Political Parties Speak about their Region
Mercenier, Heidi; Perrez, Julien ULg; Reuchamps, Min

in Reuchamps, Min (Ed.) Minority Nations in Multinational Federations. A comparative study of Quebec and Wallonia (2015)

Political parties are key political actors in both Quebec and Wallonia. As their foremost ambition is to govern their region, these parties clearly contribute to shaping its identity and image. This ... [more ▼]

Political parties are key political actors in both Quebec and Wallonia. As their foremost ambition is to govern their region, these parties clearly contribute to shaping its identity and image. This chapter aims at exploring how political parties in Quebec and in Wallonia speak about their region by focusing on an analysis of their electoral manifestos for the period 1994–2014. Using a quantitative and qualitative approach combining insights from lexicometry, cognitive linguistics and political science, the aims of this contribution are (i) to unravel how the parties perceive their region and its future development, (ii) to identify relevant evolutions in their perception of their respective region, and (iii) to assess to what extent parallels can be drawn between the two regions. [less ▲]

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See detailPositive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase.
Bury, Daniel; Dahmane, Ismahene ULg; Derouaux, Adeline ULg et al

in Biochemical pharmacology (2015), 93(2), 141-50

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan ... [more ▼]

The glycosyltransferases of family 51 (GT51) catalyze the polymerization of lipid II to form linear glycan chains, which, after cross linking by the transpeptidases, form the net-like peptidoglycan macromolecule. The essential function of the GT makes it an attractive antimicrobial target; therefore a better understanding of its function and its mechanism of interaction with substrates could help in the design and the development of new antibiotics. In this work, we have used a surface plasmon resonance Biacore((R)) biosensor, based on an amine derivative of moenomycin A immobilized on a sensor chip surface, to investigate the mechanism of binding of substrate analogous inhibitors to the GT. Addition of increasing concentrations of moenomycin A to the Staphylococcus aureus MtgA led to reduced binding of the protein to the sensor chip as expected. Remarkably, in the presence of low concentrations of the most active disaccharide inhibitors, binding of MtgA to immobilized moenomycin A was found to increase; in contrast competition with moenomycin A occurred only at high concentrations. This finding suggests that at low concentrations, the lipid II analogs bind to the acceptor site and induce a cooperative binding of moenomycin A to the donor site. Our results constitute the first indication of the existence of a positive cooperativity between the acceptor and the donor sites of peptidoglycan GTs. In addition, our study indicates that a modification of two residues (L119N and F120S) within the hydrophobic region of MtgA can yield monodisperse forms of the protein with apparently no change in its secondary structure content, but this is at the expense of the enzyme function. [less ▲]

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See detailOptimal control of a Cope rearrangement by coupling the reaction path to a dissipative bath or a second active mode
Chenel, Aurélie; Meier, Christoph; Dive, Georges et al

in The Journal of Chimical Physics (2015), 142

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See detailInvesting in the Future
Pahud de Mortanges, Charles ULg

E-print/Working paper (2015)

This paper attempts to address the challenges of how to invest in Synthetic Biology firms, most of which are relatively new start-ups and unprofitable. Valuing an early-stage firm with only a brief ... [more ▼]

This paper attempts to address the challenges of how to invest in Synthetic Biology firms, most of which are relatively new start-ups and unprofitable. Valuing an early-stage firm with only a brief operating history, little or no operating profit (or even revenue), and an immature and untested business model, could be a formidable challenge. We propose a limited number of quantitative, and a larger number of qualitative criteria. An investor may consider these when faced with analyzing a new untried business, but one he/she believes has considerable potential for success in the future. [less ▲]

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See detailElevated heart rate at 24-36h after admission and in-hospital mortality in acute in non-arrhythmic heart failure.
Lancellotti, Patrizio ULg; ANCION, Arnaud ULg; Magne, Julien et al

in International journal of cardiology (2015), 182C

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study ... [more ▼]

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36h after admission for acute non-arrhythmic HF and in-hospital mortality. METHODS AND RESULTS: We examined the association of heart rate with in-hospital mortality in a cohort of 712 patients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78+/-9 vs. 72+/-12years; p=0.0021), had higher heart rate (92+/-22 vs. 78+/-18bpm; p<0.0001), NT pro-BNP (p=0.0005), creatinine (p=0.023), were often diabetics (p=0.026) and had lower systolic and diastolic blood pressures (p<0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p<0.01). With multivariable analysis, age (p=0.037), heart rate (p<0.0001), diastolic blood pressure (p<0.001), prior ischemic heart disease (p=0.02) and creatinine (p=0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p=0.007). CONCLUSIONS: Higher heart rate 24-36h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge. [less ▲]

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See detailPulmonary Hypertension in Valvular Disease: A Comprehensive Review on Pathophysiology to Therapy From the HAVEC Group.
Magne, Julien; Pibarot, Philippe; Sengupta, Partho P. et al

in JACC. Cardiovascular imaging (2015), 8(1), 83-99

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively few published data on the ... [more ▼]

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively few published data on the prevalence, impact on outcome, and management of PH with VHD. The objective of this paper is to present a systematic review of PH in patients with VHD. PH is found in 15% to 60% of patients with VHD and is more frequent among symptomatic patients. PH is associated with higher risk of cardiac events under conservative management, during valve replacement or repair procedures, and even following successful corrective procedures. In addition to its usefulness in assessing the presence and severity of VHD, Doppler echocardiography is a key tool in diagnosis of PH and assessment of its repercussion on right ventricular function. Assessment of pulmonary arterial pressure during exercise stress echocardiography may provide additional prognostic information beyond resting evaluation. Cardiac magnetic resonance is also useful for assessing right ventricular geometry and function, which provide additional prognostic information in patients with VHD and PH. [less ▲]

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See detailThe year in cardiology 2014: valvular heart disease.
Pierard, Luc ULg; Vahanian, Alec

in European heart journal (2015)

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See detailEnquêter sur les non-publics de la culture: quelle posture de recherche pour quel dispositif méthodologique?
Ghebaur, Cosmina ULg

in Questions de Communication (2015)

Mes travaux portent sur les non-publics de la culture et leur fabrication institutionnelle, à savoir leur production par les institutions chargées de mettre en œuvre sur un territoire donné les politiques ... [more ▼]

Mes travaux portent sur les non-publics de la culture et leur fabrication institutionnelle, à savoir leur production par les institutions chargées de mettre en œuvre sur un territoire donné les politiques culturelles les concernant. Pour explorer cette question, je me place dans la perspective initiée en sociologie de l'art par Pascale Ancel et Alain Pessin (2004) et caractérisée par la remise en question de la frontière entre publics et non-publics. On peut, écrit Martine Azam (2004), être " à la fois " public et non-public s'agissant de deux objets culturels différents ou du même objet à des moments différents. L'objectif de cet article est d'expliciter les principaux choix méthodologiques que j'ai été amenée à faire en enquêtant, avec cette posture de recherche, sur une exposition photographique en extérieur organisée dans une ville de la banlieue parisienne. [less ▲]

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See detailMultiscale variability of amphipod assemblages in Posidonia oceanica meadows
Sturaro, Nicolas ULg; Lepoint, Gilles ULg; Vermeulen, Simon et al

in Journal of Sea Research (2015), 95

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and ... [more ▼]

The study of spatial patterns is of ecological importance in order to understand the causes of the distribution and abundance of organisms, and it also provides valuable basis for management and conservation. Amphipod crustaceans are key organisms in seagrass ecosystems. However, little attention has been paid to the spatial scales at which amphipod assemblages may vary. We examined variability patterns of amphipod populations inhabiting Posidonia oceanica meadows, over spatial scales spanning four orders of magnitude (1 to 1000 metres) and for two consecutive years. This study reports the scales that contributed most to spatial variation of amphipod assemblages and explores the potential processes of the observed patterns, with particular emphasis on habitat features. The number of species, the diversity and the density of some species, exhibited high variation across years. Most species showed the highest spatial variation in density and biomass at small scales (~1 and 10 m). Based on density data, the structure of amphipod assemblages did not differ at any scales investigated. The patchiness that occurred at small scales may have been only weakly related to habitat features. Instead, we postulated that behavioural processes of amphipods were likely good explanatory factors. Although, the small scale spatial variability can be an important feature of amphipod assemblages in P. oceanica meadows, many patterns probably remained undetected as they may occur at scales smaller than those investigated. [less ▲]

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See detailThe course of anaemia in children and adolescents with Crohn's disease included in a prospective registry.
Van Biervliet, Stephanie; Smets, Francoise; Hofmann, Ilse et al

in International journal of colorectal disease (2015), 30(1), 51-6

AIM: The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). METHODS: The BELCRO registry ... [more ▼]

AIM: The aim of this study is to determine the prevalence and evolution of anaemia in prospectively followed children and adolescents diagnosed with Crohn's disease (CD). METHODS: The BELCRO registry (inclusion May 2008-April 2010), describing current clinical treatment practice of children diagnosed with CD, provided data on age, height, body mass index (BMI), paediatric Crohn's disease activity index (PCDAI), therapy and haemoglobin (Hb) at diagnosis 12 and 24 months follow-up. Anaemia was defined as Hb < -2 sd, while severe anaemia was defined as Hb < -4 sd. Patients were classified as child </=13 and adolescent >13 years of age. RESULT: Ninety-six were included, 13 dropped out due to insufficient Hb data (37 females/46 males; median age 13.3 years, range 2.2-17.8 years). At diagnosis, the median Hb sd was -2.66 (-8.4; 1.07) and was correlated with the PCDAI (p = 0.013). At diagnosis, 51/83 (61 %) were anaemic and all had active disease. Hb z-score significantly improved (p < 0.0001) but 26/68 (38 %) remained anaemic at 12 months and 29/76 (38 %) at 24 months of follow-up. The correlation to the PCDAI disappeared. At 24 months, children were more likely to be anaemic. There was no difference in iron dose nor duration of iron supplements between children and adolescents. Iron treatment was more readily given to patients presenting with anaemia. Hb did not differ between patients with (n = 28) or without iron supplements. Half of the patients with persisting anaemia were given iron supplements, of which, only three were given intravenously. CONCLUSION: Anaemia remains an important extra-intestinal manifestation of CD in children. Physicians, lacking optimal treatment strategies, undertreat their patients. [less ▲]

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See detailDevelopment of the lemann index to assess digestive tract damage in patients with Crohn's disease.
Pariente, Benjamin; Mary, Jean-Yves; Danese, Silvio et al

in Gastroenterology (2015), 148(1), 52-633

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for ... [more ▼]

BACKGROUND & AIMS: There is a need for a scoring system that provides a comprehensive assessment of structural bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuring disease progression. We developed the Lemann Index and assessed its ability to measure cumulative structural bowel damage in patients with Crohn's disease (CD). METHODS: We performed a prospective, multicenter, international, cross-sectional study of patients with CD evaluated at 24 centers in 15 countries. Inclusions were stratified based on CD location and duration. All patients underwent clinical examination and abdominal magnetic resonance imaging analyses. Upper endoscopy, colonoscopy, and pelvic magnetic resonance imaging analyses were performed according to suspected disease locations. The digestive tract was divided into 4 organs and subsequently into segments. For each segment, investigators collected information on previous operations, predefined strictures, and/or penetrating lesions of maximal severity (grades 1-3), and then provided damage evaluations ranging from 0.0 (no lesion) to 10.0 (complete resection). Overall level of organ damage was calculated from the average of segmental damage. Investigators provided a global damage evaluation (from 0.0 to 10.0) using calculated organ damage evaluations. Predicted organ indexes and Lemann Index were constructed using a multiple linear mixed model, showing the best fit with investigator organ and global damage evaluations, respectively. An internal cross-validation was performed using bootstrap methods. RESULTS: Data from 138 patients (24, 115, 92, and 59 with upper tract, small bowel, colon/rectum, and anus CD location, respectively) were analyzed. According to validation, the unbiased correlation coefficients between predicted indexes and investigator damage evaluations were 0.85, 0.98, 0.90, 0.82 for upper tract, small bowel, colon/rectum, anus, respectively, and 0.84 overall. CONCLUSIONS: In a cross-sectional study, we assessed the ability of the Lemann Index to measure cumulative structural bowel damage in patients with CD. Provided further successful validation and good sensitivity to change, the index should be used to evaluate progression of CD and efficacy of treatment. [less ▲]

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