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See detailEntomologie forensique: les insectes résolvent les crimes
Verheggen, François ULg

Scientific conference (2017, February 02)

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See detailCharacterization of minimally conscious state minus and plus according to resting functional connectivity
Aubinet, Charlène ULg; Heine, Lizette; Martial, Charlotte ULg et al

Scientific conference (2017, February 01)

The minimally conscious state (MCS) has been sub-categorized in MCS plus and MCS minus, i.e. respectively with and without command following capacity. Here we aimed at characterizing differences in MCS ... [more ▼]

The minimally conscious state (MCS) has been sub-categorized in MCS plus and MCS minus, i.e. respectively with and without command following capacity. Here we aimed at characterizing differences in MCS plus as compared to MCS minus by means of functional connectivity (FC). Resting state functional magnetic resonance imagery (fMRI) was acquired in 292 MCS patients and a seed-based analysis was conducted on a convenience sample of 19 MCS patients (10 MCS plus and 9 MCS minus) and 35 healthy controls. We investigated the left and right frontoparietal networks (FPN), the auditory network and the default mode network (DMN). We employed a ROI-to-ROI analysis and a voxel-based morphometry in order to investigate the inter-hemispheric connectivity and the grey and white matter volume, respectively. A significantly higher FC was found in MCS plus as compared to MCS minus in the left FPN, specifically between the left dorso-lateral prefrontal cortex and the left temporo-occipital fusiform cortex (TOFC). The FC of auditory network, right FPN and DMN, inter-hemispheric connectivity and structure of grey and white matter did not show differences between patients groups. The clinical sub-categorization of MCS is therefore sustained by FC differences in a language-related executive control network. These patient groups are not differentiated by networks involved in auditory processing, perception of surroundings and internal thoughts, nor by differences in inter-hemispheric connectivity and in morphology. [less ▲]

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See detailA new asteroseismic diagnostic for internal rotation in γ Doradus stars
Ouazzani, Rhita-Maria; Salmon, Sébastien ULg; Antoci, V. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

With four years of nearly-continuous photometry from Kepler, we are finally in a good position to apply asteroseismology to $\gamma$ Doradus stars. In particular several analyses have demonstrated the ... [more ▼]

With four years of nearly-continuous photometry from Kepler, we are finally in a good position to apply asteroseismology to $\gamma$ Doradus stars. In particular several analyses have demonstrated the possibility to detect non-uniform period spacings, which have been predicted to be directly related to rotation. In the present work, we define a new seismic diagnostic for rotation in $\gamma$ Doradus stars that are too rapidly rotating to present rotational splittings. Based on the non uniformity of their period spacings, we define the observable $\Sigma$ as the slope of the period spacing when plotted as a function of period. We provide a one-to-one relation between this observable $\Sigma$ and the internal rotation, which applies widely in the instability strip of $\gamma$ Doradus stars. We apply the diagnostic to a handful of stars observed by Kepler. Thanks to g-modes in $\gamma$ Doradus stars, we are now able to determine the internal rotation of stars on the lower main sequence, which is still not possible for Sun-like stars. [less ▲]

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See detailModified Thomas splint-cast combination for the management of limb fractures in small equids
Ladefogen, Soren; Grulke, Sigrid ULg; Busoni, Valeria ULg et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2017)

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See detailLe droit fiscal à l’épreuve du droit civil: étude positive et prospective de la fiscalisation des revenus de certains acteurs relevant de l’économie sociale
Garroy, Sabine ULg

Conference (2017, February 01)

Présentation en 180 secondes de l'état de la recherche doctorale

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See detailStructure and distribution of the sensilla on the antennae of Tuta absoluta (Lepidoptera: Gelechiidae)
Bawin, Thomas ULg; Collard, France ULg; De Backer, Lara ULg et al

in Micron (2017), 96

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), is a widespread devastating pest that develops on tomato and other economically important solanaceous crops. Current semiochemically-based ... [more ▼]

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), is a widespread devastating pest that develops on tomato and other economically important solanaceous crops. Current semiochemically-based management strategies still fail to significantly reduce damages and need to be improved. Here we describe under scanning and transmission electron microscopy the structure and distribution of the sensilla that are displayed on adult antennae. These were similar in size between males (3424.4 ± 135.3 μm) and females (3292.1 ± 111.5 μm), being segmented into a scape, a pedicel, and a distal filiform flagellum. Eight morphological sensilla types were observed on both sexes: Böhm’s bristles, sensilla squamiformia, sensilla trichodea, sensilla basiconica (two subtypes), sensilla chaetica, sensilla coeloconica, sensilla auricillica, and sensilla styloconica. The main sexual dimorphism was related to the higher abundance of sensilla trichodea in males, twice as abundant as in females. The putative functional significance of the different sensilla types regarding the insect ecology is discussed based on the available literature. This work provides descriptions of the antennae and related sensory structures. We expect these results to help develop further electrophysiological investigations aiming to a better understanding of T. absoluta olfaction. [less ▲]

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See detailA multiscale model of the human cardiovascular system can account for the Frank-Starling effect on vascular filling therapy
Kosta, Sarah ULg; Pironet, Antoine; Negroni, Jorge et al

Poster (2017, February 01)

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See detailComparison of xenogeneic graft-versus-host reactions in humanized NSG and NSG-HLA-A2/HHD mice
Ehx, Grégory ULg; SOMJA, Joan ULg; Delens, Loïc ULg et al

Conference (2017, February 01)

Background. So far, the most commonly used mouse model of xenogeneic GVHD is NSG mice injected with human peripheral blood mononuclear cells (PBMCs). However, this model is somewhat limited by the fact ... [more ▼]

Background. So far, the most commonly used mouse model of xenogeneic GVHD is NSG mice injected with human peripheral blood mononuclear cells (PBMCs). However, this model is somewhat limited by the fact that the immunologic reaction of human PBMC is directed exclusively towards murine antigens. Aim. Here, we compared xGVHD induced by injection of human PBMCs in NSG and in NSG mice expressing the HDD construct designed for the expression of human HLA-A0201 convalently bound to human b2 microglobuline, enabling the expression of both HLA-A2 and b2 microglobuline. Methods. NSG and NSG-HLA-A2/HHD (NSG-HLA) mice were transplanted with either HLA-A2+ or HLA-A2− human PBMCs from healthy donors. Survival and xGVHD scores were monitored for the remaining days of the experiments or mice were sacrificed at day 14 to perform various analyzes on their organs. Results. NSG-HLA mice presented overall lower survival rates and higher xGVHD scores than NSG mice (median survival: 28 vs 21 days, p<0.0001). Survival difference between NSG and NSG-HLA mice was higher when they were transplanted with HLA-A2− than with HLA-A2+ donors (HLA-A2−, median survival: 35 vs 25 days, p=0.0001; HLA-A2+, median survival: 23 vs 19 days, p=0.001). Flow cytometry experiments showed higher human CD45+ cells engraftment in NSG-HLA mice in blood, spleen, bone marrow, lungs and liver. Further, lower CD4+/CD8+ T cells ratio were observed in these organs in NSG-HLA mice, highlighting a higher frequency of cytotoxic T cells. These differences of engraftment or ratio could not be attributed to proliferation or activation differences since no variation of either KI67 or HLA-DR were observed between the two mouse models. Supporting the promotion of cytotoxic T cells in NSG-HLA mice, lower frequency of CD45RA+ and higher frequency of TNF-α+ among CD8+ T cells were observed in NSG-HLA in comparison with NSG mice. Finally, preliminary results suggest a specific cytotoxicity toward HLA-A2+ cells in NSG-HLA mice. Conclusion. NSG-HLA-A2/HHD mice develop more severe xGVHD than NSG, characterized by a higher human cell engraftment and higher frequency of cytotoxic T cells, probably reacting specifically toward human HLA-A2 antigen. Therefore these mice may be a better model to study human acute GVHD. [less ▲]

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See detailL'hétérogénéité des individus en terme de longévité et l'influence de celle-ci sur le caractère redistributif des pensions
Denomerenge, Jonathan ULg

Scientific conference (2017, February 01)

Le système belge de pension comporte des éléments de redistribution en faveur des bas revenus. Cependant, l'espérance de vie d'un individu est corrélée positivement avec ses revenus. Par conséquent, les ... [more ▼]

Le système belge de pension comporte des éléments de redistribution en faveur des bas revenus. Cependant, l'espérance de vie d'un individu est corrélée positivement avec ses revenus. Par conséquent, les gens avec un revenu important bénéficient généralement de leur pension de retraite pendant un nombre d'année plus important, ce qui remet potentiellement en cause le caractère redistributif du système. [less ▲]

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See detailIdentification of proteins discriminating inflammation induced dysplasia from simple inflammation in ulcerative colitis by laser capture microdissection and label free proteomics – a pilot study
Merli, Angela-Maria ULg; QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg et al

Poster (2017, February 01)

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when ... [more ▼]

Chronic colonic inflammation in ulcerative colitis (UC) may induce dysplasia, which can itself progress and transform into neoplasia. Diagnosis of dysplasia in UC remains difficult particularly when tissue inflammation is present. The aim of this retrospective pilot study was to highlight proteins specifically associated with inflammation induced dysplasia in UC. We performed a pilot experiment on 15 Formalin-Fixed, Paraffin-Embedded (FFPE) samples isolated from 5 cases of UC patients with a Polypoïd Pedunculated dysplasia (UC-PP). We compared the proteomes of the UC-PP, the inflammatory (UC-I) and the normal (UC-NL) tissues of each patient. We performed Laser Capture Microdissection (LCM) in order to collect only epithelial cells, avoiding inflammatory infiltrating ones. Label free proteomic analysis using a 2D-nanoUPLC coupled with a hybrid Quadrupole-Orbitrap was applied, as well as differential analysis on the paired samples. Immunohistochemistry (IHC) characterisation of one of the selected proteins of interest was used for validation. Out of 985 quantified proteins, 7 were found significantly more abundant in UC-PP compared to UC-I tissues, with 6 being only detected in UC-PP using proteomics. One of these is Solute Carrier Family 12 member 2 (SLC12A2), also known as Na-K-2Cl co-transporter 1 (NKCC1), a protein involved in ionic balance, in T-cell migration promotion and in some features involved in cancer development like proliferation, migration or invasion. IHC results obtained were in correlation with proteomic results and showed that SLC12A2 was more abundant in UC-PP tissue than in UC-I and UC-NL tissues, with a signal clearly delimiting the dysplastic region from the surrounding inflammatory tissue. This pilot experiment shows a different proteomic profile in inflammation-associated dysplasia and simple inflammation. This should be replicated using other types of dysplasia in IBD. SLC12A2 could be a potential biomarker of inflammation-associated dysplasia. [less ▲]

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See detail“Don't pretend to be my friend!” When an informal brand communication style backfires on social media
Gretry, Anaïs ULg; Horváth, Csilla; Belei, Nina et al

in Journal of Business Research (2017), 74

Social media are now essential platforms for marketing communications, and the volume of consumer-brand in- teractions on these platforms is exploding. Even so, it remains unclear how brands should ... [more ▼]

Social media are now essential platforms for marketing communications, and the volume of consumer-brand in- teractions on these platforms is exploding. Even so, it remains unclear how brands should communicate with consumers to foster relationships and, in particular, to gain their trust. A fundamental decision in this regard is the choice of a communication style, specifically, whether an informal or a formal style should be used in social media communications. In this paper, we investigate how adopting an informal (vs. formal) communication style affects brand trust and demonstrate that using an informal style can either have a positive or negative effect on brand trust, depending on whether consumers are familiar with the brand or not. We further show that these ef- fects occur because consumers expect brands to behave according to social norms, such that the use of an infor- mal style is perceived to be appropriate for familiar brands and inappropriate for unfamiliar ones. [less ▲]

Detailed reference viewed: 77 (8 ULg)
See detailZinc, manganese and iron interaction within the frd3 Arabidopsis mutant
Scheepers, Maxime ULg; Spielmann, Julien ULg; Goormaghtigh, Erik et al

Poster (2017, February 01)

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See detailUsing unsupervised clustering method and SNP-based information to identify fine-level population structure
Chaichoompu, Kridsadakorn ULg; Yazew, Fentaw Abegaz; Tongsima, Sissades et al

Poster (2017, February 01)

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See detailImproved Blood Glucose Forecasting Models using Changes in Insulin Sensitivity in Intensive Care Patients
Uyttendaele, Vincent ULg; Dickson, Jennifer; Shaw, Geoff et al

Poster (2017, February 01)

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy ... [more ▼]

Introduction: Hyperglycaemia, hypoglycaemia and glycaemic variability are associated with worsened outcomes and increased mortality in intensive care units. Glycaemic control (GC) using insulin therapy has shown improved outcomes, but have been proven difficult to repeat or achieve safely. STAR (Stochastic TARgeted) is a model-based glycaemic control protocol using a stochastic model to forecast distributions of likely future changes in insulin sensitivity (SI) based on its current value. This can be used to determine likely future blood glucose (BG) levels for a given intervention, enabling the most optimal dose selection that best overlaps a clinically defined BG target band. This study presents a novel 3D model capable to predict likely future distribution of SI using both current SI and its prior variability (%ΔSI). Methods: Metabolic data from 3 clinical ICU cohorts totalling 819 episodes and 68629 hours of treatment under STAR and SPRINT protocols are used in this study. Data triplets (%ΔSIn, SIn, SIn+1) are created and binned together in a range of %ΔSI = [-100%, 200%] and SIn = [1.0e-7, 2.1e-3] in bin sizes of %ΔSI = 10% and SIn = 0.5e-4. The 5th, 50th, and 95th percentile of SIn+1 are determined for each bin where data density is high enough (>100 triplets) and compared to the previous stochastic model. The predictive power of the two models are compared by computing median [IQR] per-patient percentage prediction of SI within the 5th-95th and 25th-75th percentile ranges of model predictions. Results: Results show the previous model is over-conservative for ~77% of the data, mainly where %ΔSI is within an absolute 25% change. The percentage change in the 90% CI width in this region is reduced by ~25-40%. Conversely, non-conservative regions are also identified, with 90% CI width increased up to ~80%. Predictive power is similar for both model (60.3% [47.8%, 71.5%] vs. 51.2 [42.9%, 59.2%] within 25th-75th and 93.6% [85.7%, 97.3%] vs. 90.7% [84.4%, 94.6%] within 5th-95th range). Conclusions: The new 3D model achieved similar predictive power as the previous model by reducing the 5th-95th percentile prediction range for 77% of the data, predominantly where SI is stable. If the conservatism of the previous model reduces risk of hypoglycaemia, it also inhibits the controller’s ability to reduce BG to the normal range by safely using more aggressive dosing. The 3D new model thus better characterises patient-specific response to insulin, and allows more optimal dosing, increasing performance and safety. [less ▲]

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See detailMicroalgues: du laboratoire au pilote industriel pour la production de molécules bioactives
Franck, Fabrice ULg; Gerards, Thomas ULg

Scientific conference (2017, February 01)

Detailed reference viewed: 20 (2 ULg)