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See detailVaccination guidelines in hematopoietic transplant patients : recommendations from the BHS Transplant Committee
Moors, I.; Callens, S.; BEGUIN, Yves ULg et al

in Belgian Journal of Hematology (in press)

Over the past years, hematopoietic stem cell transplantation (HSCT) is increasingly used as a consolidation therapy in several haematological diseases and solid tumours. In the post-transplantation period ... [more ▼]

Over the past years, hematopoietic stem cell transplantation (HSCT) is increasingly used as a consolidation therapy in several haematological diseases and solid tumours. In the post-transplantation period, the immunity of HSCT recipients is impaired due to toxicity of the pre-HSCT treatment (chemo- and/or radiotherapy) and the conditioning regimen with reset of the immune system and – in case of allogeneic stem cell transplantation – possible graft-versus-host-disease (GVHD) and use of immunosuppressive drugs. This leads to a considerably increased risk of infections, with higher morbidity and mortality in these patients. Therefore, prevention of infections, through antibiotic prophylaxis, life style adjustments, germfree nutrition and revaccination, is of major importance to improve outcomes. In this article we present the Belgian guidelines for vaccination after hematopoietic stem cell transplantation, based on available data in the literature and international guidelines, taking into account the availability of vaccines and - if applicable - their reimbursement in Belgium. We present a general vaccination schedule for post-HSCT patients, a proposition for pre-transplant vaccination and donor vaccination, and an overview of special indications such as travel vaccinations and vaccinations of close contacts and health care workers, with guidelines for titer follow up. [less ▲]

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See detailA European patient record study on diagnosis and treatment of chemotherapy-induced anaemia
Ludwig, H.; Aapro, M.; Bokemeyer, C. et al

in Supportive Care in Cancer (in press)

Purpose – Patients with cancer frequently experience chemotherapy‐induced anaemia (CIA) and iron deficiency (ID). Erythropoiesis‐stimulating agents (ESA), iron supplementation and blood transfusions are ... [more ▼]

Purpose – Patients with cancer frequently experience chemotherapy‐induced anaemia (CIA) and iron deficiency (ID). Erythropoiesis‐stimulating agents (ESA), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Methods – Medical oncologists and/or haematologists from nine European countries (n=375) were surveyed on their last five cancer patients treated for CIA (n=1730). Information was collected on tests performed at diagnosis of anaemia, levels of haemoglobin (Hb), serum ferritin and transferrin saturation (TSAT), and applied anaemia therapies. Results – Diagnostic tests and therapies for CIA varied across Europe. Anaemia and iron status were mainly assessed by Hb (94%) and ferritin (48%) measurements. TSAT was only tested in 14%. At anaemia diagnosis, 74% of patients had Hb ≤10g/dL, including 15% with severe (Hb <8g/dL) anaemia. Low iron levels (ferritin ≤100ng/mL) were detected in 42% of evaluated patients. ESA was the most commonly used treatment (63%) and 30% of ESA‐treated patients also received iron supplementation. Most iron‐treated patients (74%) received an oral iron; intravenous iron was administered to 26%. 52% of patients received transfusions and in 76% of these, transfusions formed part of a regular anaemia treatment regimen. Management practices were similar in 2009 and 2011. Conclusion – Management of anaemia and iron status in patients treated for CIA varies substantially across Europe. Iron status is only assessed in half of the patients. In contrast to clinical evidence, iron treatment is underutilised and mainly based on oral iron supplementation. Implementation of guidelines needs to be increased, particularly the minimisation of blood transfusions. [less ▲]

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See detailCorporéité et politique chez Deleuze : continuité et littéralité autour du corps sans organes
Soskin, Jonathan ULg

in Gléonec, Anne (Ed.) Corps, corporatisme, corporation, et les régimes de corporéité du social (in press)

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See detailLe Paléolithique supérieur européen. Bilan 2013
Noiret, Pierre ULg; Leesch, Denise

Book published by Service de Préhistoire de l'Université de Liège (in press)

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See detailNew Amphiphilic Neamine Derivatives Active against Resistant Pseudomonas aeruginosa and Their Interactions with Lipopolysaccharides
Sautrey, Guillaume; Zimmerman, Louis; Deleu, Magali ULg et al

in Antimicrobial Agents and Chemotherapy (in press)

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See detailImages et rôles du professeur de langues dans le cadre de la mondialisation. Le cas de la mobilité étudiante européenne
Defays, Jean-Marc ULg; Meunier, Deborah ULg

in Actes du Colloque international « Contexte global et contextes locaux : tensions, convergences et enjeux en didactique des langues » (in press)

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See detailImpact of co-transplantation of mesenchymal stem cells on lung function after unrelated allogeneic hematopoietic stem cell transplantation following non-myeloablative conditioning
MOERMANS, Catherine ULg; LECHANTEUR, Chantal ULg; BAUDOUX, Etienne ULg et al

in Transplantation (in press)

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal ... [more ▼]

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal models, MSC were shown to cause pulmonary alterations after systemic administration. The impact of MSC infusion on lung function has not been studied in humans. The objective of the study was to investigate the impact of MSC co-infusion on lung function and airway inflammation as well as on the incidence of pulmonary infections and cytomegalovirus (CMV) reactivation after HSCT. Methods: We have prospectively followed 30 patients who underwent unrelated HSCT with MSC co-infusion after non-myeloablative conditioning (NMA). Each patient underwent detailed lung function testing (FEV1, FVC, FEV1/FVC, RV, TLC, DLCO and KCO) and measurement of exhaled nitric oxide before HSCT and 3, 6 and 12 months posttransplant. The incidence of pulmonary infections and CMV reactivation were also monitored. This group was compared with another group of 28 patients who underwent the same type of transplantation but without MSC co-infusion. Results: Lung function tests did not show important modifications over time and did not differ between the MSC and control groups. There was a higher 1-year incidence of infection, particularly of fungal infections, in patients having received a MSC co-infusion. There was no difference between groups regarding the 1-year incidence of CMV reactivation. Conclusions: MSC co-infusion does not induce pulmonary deterioration 1 year after HSCT with NMA conditioning. MSC appear to be safe for the lung but close monitoring of pulmonary infections remains essential. [less ▲]

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See detailErythropoietin therapy after allogeneic hematopoietic cell transplantation : a prospective randomized trial
JASPERS, Aurélie ULg; Baron, Frédéric ULg; WILLEMS, Evelyne ULg et al

in Blood (in press)

We conducted a prospective randomized trial to assess hemoglobin (Hb) response to recombinant human erythropoietin (rhEPO) therapy after hematopoietic cell transplantation (HCT). Patients (n=131) were ... [more ▼]

We conducted a prospective randomized trial to assess hemoglobin (Hb) response to recombinant human erythropoietin (rhEPO) therapy after hematopoietic cell transplantation (HCT). Patients (n=131) were randomized (1:1) between no treatment (control arm) or erythropoietin (Neorecormon®) at 500 U/kg/week (EPO arm). Patients were also stratified in 3 cohorts: patients undergoing myeloablative HCT with rhEPO to start on day 28, patients given nonmyeloablative HCT (NMHCT) with rhEPO to start on day 28, and patients also given NMHCT but with rhEPO to start on day 0. The proportion of complete correctors (i.e. achieving Hb ≥ 13 g/dL) before day 126 post-transplant (primary endpoint) was 8.1% in the control arm (median not reached) and 63.1% in the EPO arm (median time 90 days) (p<0.001). Hb levels were higher and transfusions requirements decreased (p<0.001) in the EPO arm, but not during the first month in the nonmyeloablative cohort starting rhEPO on day 0. There was no difference in rates of thrombo-embolic events or other complications between the 2 arms. This is the first randomized trial to demonstrate that rhEPO therapy hastens erythroid recovery and decreases transfusion requirements when started one month after allogeneic HCT. There was no benefit to start rhEPO earlier after NMHCT. [less ▲]

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See detailA formulation on the special Euclidean group for dynamic analysis of multibody systems
Sonneville, Valentin ULg; Bruls, Olivier ULg

in Journal of Computational and Nonlinear Dynamics (in press)

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See detailDu judiciaire au politique : étude logométrique des formes d’expression oratoire chez Cicéron
Longrée, Dominique ULg

in Anreiter, P; Hajnal, I; Mairhofer, E (Eds.) et al Festschrift Manfred Kienpointner (in press)

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See detailLangues anciennes et analyse statistique : cinquante ans après – Distances textuelles et intertextualités
Longrée, Dominique ULg

Book published by Les études classiques (in press)

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See detailAboveground biomass mapping of African forest mosaics using canopy texture analysis: towards a regional approach.
Bastin, Jean-François ULg; Barbier, Nicolas; Couteron, Pierre et al

in Ecological Applications (in press)

In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity ... [more ▼]

In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity to characterize forest canopy structure and to quantify aboveground biomass (AGB) at less expense than methods based on airborne remote sensing data. Among the methods for processing these VHR images, Fourier textural ordination (FOTO) presents a good potential to detect forest canopy structural heterogeneity and therefore to predict AGB variations. Notably, the method does not saturate at intermediate AGB values as do pixelwise processing of available space borne optical and radar signals. However, a regional scale application requires to overcome two difficulties: (i) instrumental effects due to variations in sun-scene-sensor geometry or sensor-specific responses that preclude the use of wide arrays of images acquired under heterogeneous conditions and (ii) forest structural diversity including monodominant or open canopy forests, which are of particular importance in Central Africa. In this study, we demonstrate the feasibility of a rigorous regional study of canopy texture by harmonizing FOTO indices of images acquired from two different sensors (Geoeye-1 and QuickBird-2) and different sun-scene-sensor geometries and by calibrating a piecewise biomass inversion model using 26 inventory plots (1 ha) sampled across very heterogeneous forest types. A good agreement was found between observed and predicted AGB (RSE=15%; R²=0.85; p-value<0.001) across a wide range of AGB levels from 26 Mg/ha to 460 Mg/ha, and was confirmed by cross validation. A high-resolution biomass map (100 m pixels) was produced for a 400 km² area, and predictions obtained from both imagery sources were consistent with each other (r=0.86; slope=1.03; intercept=12.01 Mg/ha). These results highlight the horizontal structure of forest canopy as a powerful descriptor of the entire forest stand structure and heterogeneity. In particular, we show that quantitative metrics resulting from such textural analysis offer new opportunities to characterize the spatial and temporal variation of the structure of dense forests and may complement the toolbox used by tropical forest ecologists, managers or REDD+ national monitoring, reporting and verification bodies. [less ▲]

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See detailAtomistic account of structural and dynamical changes induced by small binders in the double helix of a short DNA
Fresch, Barbara ULg; Remacle, Françoise ULg

in Physical Chemistry Chemical Physics [=PCCP] (in press)

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See detailDe linguae latinae usu, Actes du 13e Colloque international de Linguistique latine, Bruxelles et Liège, 4-9 avril 2005
Longrée, Dominique ULg; Lenoble, Muriel; Moulart, Marie

Book published by Peeters (in press)

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See detailCarte géologique de Wallonie (Belgique) 1/10.000, 48/8 Clavier
Barchy, Laurent; Marion, Jean-Marc ULg

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition in 1902 (at 1/40.000, by Lohest, Forir ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition in 1902 (at 1/40.000, by Lohest, Forir and Mourlon). [less ▲]

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See detailCarte géologique de Wallonie (Belgique) 1/10.000, 59/4 Nassogne
Barchy, Laurent; Dejonghe, Léon; Marion, Jean-Marc ULg

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000 based on a new field work and using previous scientific data, produced since the previous edition published in 1900 (Stainer)

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See detailLes désignations romanes de l'ECUREUIL
Boutier, Marie-Guy ULg; Baiwir, Esther ULg

in Contini, Michel; Veny, Joan (Eds.) Atlas linguistique roman (ALiR) (in press)

L'ALiR a pour objectif de fournir une description globale du lexique roman par champ sémantique, à travers l'étude onomasiologique des désignations romanes de concepts. Les analyses lexicale, phonétique ... [more ▼]

L'ALiR a pour objectif de fournir une description globale du lexique roman par champ sémantique, à travers l'étude onomasiologique des désignations romanes de concepts. Les analyses lexicale, phonétique, morphosyntaxiques sont mises en valeur par la production de cartes interprétatives. [less ▲]

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See detailElastic damage to crack transition in a coupled non-local implicit discontinuous Galerkin/extrinsic cohesive law framework
Wu, Ling ULg; Becker, Gauthier ULg; Noels, Ludovic ULg

in Computer Methods in Applied Mechanics & Engineering (in press)

One current challenge related to computational fracture mechanics is the modeling of ductile fracture and in particular the damage to crack transition. On the one hand, continuum damage models, especially ... [more ▼]

One current challenge related to computational fracture mechanics is the modeling of ductile fracture and in particular the damage to crack transition. On the one hand, continuum damage models, especially in their non-local formulation which avoids the loss of solution uniqueness, can capture the material degradation process up to the localization of the damage, but are unable to represent a discontinuity in the structure. On the other hand cohesive zone methods can represent the process zone at the crack tip governing the crack propagation, but cannot account for the diffuse material damaging process. In this paper we propose to combine, in a small deformations setting, a non-local elastic damage model with a cohesive zone model. This combination is formulated within a discontinuous Galerkin nite element discretization. Indeed this DG weak formulation can easily be developed in a non-local implicit form and naturally embeds interface elements that can be used to integrate the traction separation law of the cohesive zone model. The method remains thus consistent and computationally e cient as compared to other cohesive element approaches. The effects of the damage to crack transition and of the mesh discretization are respectively studied on the compact tension specimen and on the double-notched specimen, demonstrating the efficiency and accuracy of the method. [less ▲]

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