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In vivo PET/CT in a human glioblastoma chicken chorioallantoic membrane model: A new tool for oncology and radiotracer development.; Turtoi, Andrei ; Blomme, Arnaud et alin Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (in press) For many years the laboratory mouse has been used as the standard model for in vivo oncology research, particularly in the development of novel PET tracers, but the growth of tumors on chicken ... [more ▼] For many years the laboratory mouse has been used as the standard model for in vivo oncology research, particularly in the development of novel PET tracers, but the growth of tumors on chicken chorioallantoic membrane (CAM) provides a more rapid, low cost and ethically sustainable alternative. For the first time, we demonstrate the feasibility of in vivo PET and CT imaging in a U87 glioblastoma tumor model on chicken chorioallantoic membrane (CAM), with the aim of applying this model for screening of novel PET tracers. Methods: U87 glioblastoma cells were implanted on the CAM at day 11 post-fertilization and imaged at day 18. A small animal imaging cell was used to maintain incubation and allow anesthesia using isoflurane. Radiotracers were injected directly into the exposed CAM vasculature. Sodium [18F]fluoride was used to validate the imaging protocol, demonstrating that image-degrading motion can be removed with anesthesia. Tumor glucose metabolism was imaged using [18F]fluorodeoxyglucose and tumor protein synthesis was imaged using 2-[18F]fluoro-L-tyrosine. Anatomical images were obtained by contrast enhanced CT, facilitating clear delineation of the tumor, delineation of tracer uptake in tumor versus embryo and accurate volume measurements. Results: PET imaging of tumor glucose metabolism and protein synthesis was successfully demonstrated in the CAM U87 glioblastoma model. Catheterization of CAM blood vessels facilitated dynamic imaging of glucose metabolism with [18F]fluorodeoxyglucose and demonstrated the ability to study PET tracer uptake over time in individual tumors, while CT imaging improved the accuracy of tumor volume measurements. Conclusion: In summary, we describe the novel application of PET/CT in the CAM tumor model, with optimization of typical imaging protocols. PET imaging in this valuable tumor model could prove particularly useful for rapid, high-throughput screening of novel radiotracers. [less ▲] Detailed reference viewed: 16 (9 ULg) Les cultes de l'île de Cos après le synécisme de 366 avant notre èrePaul, Stéphanie ![]() Book published by Presses Universitaires de Liège (in press) Detailed reference viewed: 24 (3 ULg) Confesseur du Prince : un profil singulier ? L’exemple de la cour espagnole de Bruxelles au XVIIe siècle.Pirlet, Pierre-François ![]() in [Titre à préciser] (in press) Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son ... [more ▼] Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son représentant pour les aspects temporels, ce religieux a la faculté unique d'examiner, de conseiller et de juger la spiritualité du premier personnage de l'État. Attaché à la personne du Prince, les relations de cet ecclésiastique avec les autres courtisans ne peuvent être appréhendées au moyen d'une grille de lecture hiérarchisant les rapports sociaux : échappant à l'organisation laïque – mais pas protocolaire – de la cour et ne dépendant pas directement de la Chapelle royale, le confesseur bénéficie d'une autonomie relative. En outre, son pouvoir politique, en partie officiel grâce aux dignités et charges dont ce religieux est pourvu, est avant tout perçu comme une magistrature d'influence à la portée difficilement mesurable. Enfin, les obligations matérielles liées à l'appartenance de ce prélat à un ordre religieux achèvent de distinguer cet ecclésiastique des autres serviteurs princiers. Cette communication visera à distinguer les particularités de la charge de confesseur princier au sein de la société de cour. L'étude portera particulièrement sur la cour de Bruxelles durant la première moitié du xviie siècle. [less ▲] Detailed reference viewed: 15 (4 ULg) Turbulent flows in straight compound open-channel with a transverse embankment on the floodplainPeltier, Yann ; ; et alin Journal of Hydraulic Research (in press) Detailed reference viewed: 19 (4 ULg) Les jeux vidéo violents augmentent-ils le biais d’attribution hostile chez des préadolescents?; Mathys, Cécile ; Born, Michel ![]() in Revue de Psychoéducation (in press), 42 Detailed reference viewed: 21 (7 ULg) Diet of harbor porpoises along the Dutch coast: a combined stable isotope and stomach contents approach; Michel, Loïc ; Lepoint, Gilles et alin Marine Mammal Science (in press) High stranding frequency of porpoises, Phocoena phocoena, along the Dutch coast since 2006 has led to increased interest in the ecology of porpoises in the North Sea. Stranded porpoises were collected ... [more ▼] High stranding frequency of porpoises, Phocoena phocoena, along the Dutch coast since 2006 has led to increased interest in the ecology of porpoises in the North Sea. Stranded porpoises were collected along the Dutch coast (2006–2008) and their diet was assessed through stomach content and stable isotope analysis (d13C and d15N) of porpoise muscle and prey. Stable isotope analysis (SIAR) was used to estimate the con- tribution of prey species to the porpoises’ diet. This was compared to prey composi- tion from stomach contents, to analyze differences between long- and short-term diet. According to stomach contents, 90.5% of the diet consisted of gobies, whiting, lesser sandeel, herring, cod, and sprat. Stable isotope analysis revealed that 70-83% of the diet consisted of poor cod, mackerel, greater sandeel, lesser sandeel, sprat, and gobies, highlighting a higher importance of pelagic, schooling species in the porpoises’ diet compared to stomach contents. This could be due to prey distribution as well as differ- ences in behavior of porpoises and prey between the coastal zone and offshore waters. This study supports the need for multi-method approaches. Future ecological and fishery impact assessment studies and management decisions for porpoise conservation should acknowledge this difference between the long- and short-term diet. [less ▲] Detailed reference viewed: 66 (15 ULg) La primauté de l'intentionnalité et ses conséquences philosophiquesBoccaccini, Federico ![]() in Bulletin d'Analyse Phénoménologique (in press) Detailed reference viewed: 5 (0 ULg) Manuel de Science politiqueJamin, Jérôme ; ; et alBook published by De Boeck (in press) Detailed reference viewed: 16 (1 ULg) Anders Breivik et le ‘marxisme culturel’ : Etats-Unis / EuropeJamin, Jérôme ![]() in Amnis : Revue de Civilisation Contemporaine Europes/Amériques (in press), 12 2013 Detailed reference viewed: 19 (5 ULg) Macroporous poly(ionic liquid)s and poly(acrylamide)s monoliths from CO2-in-water emulsion templates stabilized by sugar-based surfactantsBoyère, Cédric ; ; Léonard, Alexandre et alin Journal of Materials Chemistry A: Materials for energy and sustainability (in press) Highly interconnected poly(acrylamide) (PAM) and poly(vinylimidazolium) (PVIm) porous monoliths were templated by carbon 10 dioxide-in-water (CO2/W) high internal phase emulsions (HIPEs), a toxic-solvent ... [more ▼] Highly interconnected poly(acrylamide) (PAM) and poly(vinylimidazolium) (PVIm) porous monoliths were templated by carbon 10 dioxide-in-water (CO2/W) high internal phase emulsions (HIPEs), a toxic-solvent free process. A range of sugar-based fluorinated surfactants prepared by chemoenzymatic synthesis were used as emulsifiers. Both the concentration and the structure of the surfactants, especially the length of their CO2-philic part and of their spacer between the sugar head and the tail, were found to strongly affect the cellular structure and morphology of the PAM polyHIPEs, i.e. the size of pores and cells. A mannose derivative bearing a chain ranging from 6 to 10 perfluorinated carbons and a long spacer emerged as the best stabilizer, leading to a porous monolith with average pores and 15 cells sizes (about 2.6 1m and 5-10 1m, respectively) among the lowest reported for polyHIPEs produced from CO2/W emulsions. The same template then served for the preparation of the first macroporous poly(ionic liquid)s (PILs) polyHIPE by using 1-vinyl-3- ethylimidazolium bromide as monomer. Shrinkage of the final material was prevented by adjusting the divinylimidazolium crosslinker content. The resulting low density polyHIPE exhibits small spherical cells (~5 1m) connected by numerous small pores (~2 1m), confirming that the CO2/W HIPE templating methodology based on fluorinated glycosurfactants is a technique of choice for the 20 preparation of macroporous PILs. [less ▲] Detailed reference viewed: 19 (11 ULg) Montrer l’invisible. Les dieux et leurs statues dans la céramique grecqueCollard, Hélène ![]() in Borgeaud, Philippe; Fabiano, Doralice (Eds.) Perception et construction du divin dans l'Antiquité (in press) This contribution examines a group of specific vases, which lead to a number of interesting questions about the status of divine image and the modes of divine representation in ancient Greece. These are ... [more ▼] This contribution examines a group of specific vases, which lead to a number of interesting questions about the status of divine image and the modes of divine representation in ancient Greece. These are Attic and South Italian items on which deities are shown standing next to their own statues. The issue that immediately arises concerns the meaning of this type of representation, which “doubles” in a sense the divinity. We attempt to show that the “doubling” is not redundant, as these pictures depict two different modes of presence. [less ▲] Detailed reference viewed: 14 (0 ULg) Brain metabolic dysfunction in Capgras delusion during Alzheimer’s disease: a positron emission tomography studyJedidi, Haroun ; ; et alin American Journal of Alzheimer's Disease & Other Dementias (in press) Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since ... [more ▼] Capgras delusion is characterized by the misidentification of people and by the delusional belief that the misidentified persons have been replaced by impostors, generally perceived as persecutors. Since little is known regarding the neural correlates of Capgras syndrome, the cerebral metabolic pattern of a patient with probable Alzheimer’s disease (AD) and Capgras syndrome was compared with those of 24 healthy elderly subjects and 26 AD patients without delusional syndrome. Compared to the healthy and AD groups, the patient had significant hypometabolism in frontal and posterior midline structures. In light of current neural models of face perception, our patient’s Capgras syndrome may be related to impaired recognition of a familiar face, subserved by the posterior cingulate/precuneus cortex, and impaired reflection about personally relevant knowledge related to a face, subserved by the dorsomedial prefrontal cortex. [less ▲] Detailed reference viewed: 25 (10 ULg) Comparative magnetotail flapping: An overview of selectec events ad Earth, Jupiter and Saturn; ; et al in Annales Geophysicae [= ANGEO] (in press) Detailed reference viewed: 13 (1 ULg) "How very un-Dominican of him" ou la merveilleuse masculinité d’Oscar WaoBerlage, Pauline ![]() in Banoun, Bernard; Tomiche, Anne; Zapata, Mónica (Eds.) Fictions au masculin (in press) Dans le cadre de la littérature de l’exil, il a souvent été question de subjectivités entre-deux, de sujets in-between, et de réflexions entre un « ici » aliénant et un « là-bas » idéalisé. En réaction à ... [more ▼] Dans le cadre de la littérature de l’exil, il a souvent été question de subjectivités entre-deux, de sujets in-between, et de réflexions entre un « ici » aliénant et un « là-bas » idéalisé. En réaction à cette pensée binaire et suite aux réflexions postcoloniales, les mouvements migratoires sont aujourd’hui célébrés et associés aux figures d’identités composées . Par ailleurs, notre compréhension des migrations a fortement évolué depuis une quinzaine d’années, on ne parle donc plus aujourd’hui de relocalisations unidirectionnelles et permanentes mais plutôt de communauté transnationale et de cultures globalisées selon un agencement postcolonial . C’est dans cette optique que j’observerai quelles sont les différentes masculinités issues de la diaspora dominicaine en confrontation dans le roman de Junot Díaz La Brève et Merveilleuse Vie d’Oscar Wao, et, face à ces tensions de genre, de quelle manière la subjectivité masculine d’Oscar Wao est singulière. [less ▲] Detailed reference viewed: 48 (24 ULg) Auroral counterpart of magnetic field dipolarizations in Saturn’s tail; ; et al in Planetary and Space Science (in press) Detailed reference viewed: 11 (0 ULg) Jupiter's aurora in ultraviolet and infrared: simultaneous observations with the Hubble Space Telescope and the NASA Infrared Telescope FacilityRadioti, Aikaterini ; ; Bonfond, Bertrand et alin Journal of Geophysical Research. Space Physics (in press) Detailed reference viewed: 9 (0 ULg) Robust estimation for ordinal regressionCroux, Christophe ; Haesbroeck, Gentiane ; Ruwet, Christel ![]() in Journal of Statistical Planning & Inference (in press) Ordinal regression is used for modelling an ordinal response variable as a function of some explanatory variables. The classical technique for estimating the unknown parameters of this model is Maximum ... [more ▼] Ordinal regression is used for modelling an ordinal response variable as a function of some explanatory variables. The classical technique for estimating the unknown parameters of this model is Maximum Likelihood (ML). The lack of robustness of this estimator is formally shown by deriving its breakdown point and its influence function. To robustify the procedure, a weighting step is added to the Maximum Likelihood estimator, yielding an estimator with bounded influence function. We also show that the loss in efficiency due to the weighting step remains limited. A diagnostic plot based on the Weighted Maximum Likelihood estimator allows to detect outliers of different types in a single plot. [less ▲] Detailed reference viewed: 1 (1 ULg) Nutrient return to the forest floor through litter and throughfall under 7 forest species after conversion from Norway spruceCarnol, Monique ; in Forest Ecology & Management (in press), (0), Tree species can influence nutrient return to the forest floor and nutrient cycling through the amount and chemical composition of throughfall and litter. We compared foliar nutrient concentrations ... [more ▼] Tree species can influence nutrient return to the forest floor and nutrient cycling through the amount and chemical composition of throughfall and litter. We compared foliar nutrient concentrations, litter production, nutrient return and soil chemistry under 7 tree species planted on the same site after two generations of a Norway spruce (Picea abies (L.) Karst.) monoculture. Common alder (Alnus glutinosa (L.) Gaertn.), european beech (Fagus sylvatica L.), pedunculate oak (Quercus robur L.), silver birch (Betula pendula Roth.), goat willow (Salix caprea L.) and rowan (Sorbus aucuparia L.) were planted within an experimental catchment on poor acid soil in south-eastern Belgium. Measurements were performed during one year, 11 years after planting. This study demonstrated that Ca, Mg, K and N concentrations in foliage and leaf litter are tree-species specific. Fresh foliage and foliar litter N concentrations were highest in alder and willow, while Ca, Mg and K concentrations were highest in rowan. Litter Ca concentrations were approximately twice in rowan than those of all other species. Differences in nutrient concentrations between foliage and leaf litter depended both on the element concerned and on tree species. The total average litterfall biomass ranged from 615 kg ha−1 year−1 under oak to 3122 kg ha−1 year−1 under rowan. Foliar litterfall represented above 85% for beech, spruce and oak, 70% for alder and willow and ca. 55% for birch and rowan. Reproductive parts formed 44% of total litterfall biomass under rowan. Ca, Mg, K and N return via throughfall, foliar litter and reproductive parts were higher under accompanying tree species (alder, birch, willow, rowan) than under the main commercial tree species (oak, beech, spruce). Total N return was in the order of 50 kg ha−1 year−1 under accompanying species, 33 kg ha−1 year−1 under spruce and near 20 kg ha−1 year−1 under beech and oak. Under rowan, total Ca, Mg, and K return to the forest floor through throughfall deposition, litterfall of leaves and reproductive parts amounted to 47, 9 and 66 kg ha−1 year−1, respectively. Compared to spruce, forest floor pHH20 has increased by 0.4 unit under birch and rowan, and exchangeable Ca2+, Mg2+, K+ have increased about threefold under rowan. Planting rowan as accompanying species may therefore represent an interesting management option for improving forest floor chemistry on nutrient poor sites through Ca, Mg, and K nutrient return. [less ▲] Detailed reference viewed: 20 (1 ULg) Preference for rich, random tactile stimulation in woodlice (Porcellio scaber)Anselme, Patrick ![]() in Learning & Motivation (in press) All living beings exhibit preferences for a variety of biologically significant stimuli. Interestingly, stimuli without biological significance, such as saccharine, are also able to induce preferences in ... [more ▼] All living beings exhibit preferences for a variety of biologically significant stimuli. Interestingly, stimuli without biological significance, such as saccharine, are also able to induce preferences in vertebrates. Can invertebrates show preferences for biologically neutral cues as well – i.e. independently of any conditioning process? Experiment 1 aimed to determine the preference of woodlice (Porcellio scaber Latreille 1804) exposed to floor textures that differed in tactile cues, how they expressed their tactile preference, and whether they were able to inhibit that preference when a shelter of variable quality was available on the non-preferred floor texture. Experiment 2 provided additional information relative to the strength of woodlice’s tactile preference as well as the way of measuring it. Experiment 3 complemented the previous one in attempting to determine woodlice’s preference for regular versus random tactile cues. Taken together, the results suggest that (i) woodlice are able to process sensory information relative to biologically non-significant stimuli and (ii) that, because the motivation induced can interact with sheltering as a survival-related behavior, the processing of both types of motivation might depend on the same brain systems. [less ▲] Detailed reference viewed: 28 (2 ULg) Evaluation des processus de mise en oeuvre des plans de cohésion sociale: rapport finalItaliano, Patrick ; Fallon, Catherine ; Thiry, Aline et alReport (in press) Ce rapport synthétise la recherche d'évaluation des plans de cohésion sociale de la région Wallonne quant à leur mise en oeuvre locale. Il couvre les aspects de gouvernance locale, de construction de ... [more ▼] Ce rapport synthétise la recherche d'évaluation des plans de cohésion sociale de la région Wallonne quant à leur mise en oeuvre locale. Il couvre les aspects de gouvernance locale, de construction de partenariats public-associatif, d'évaluation participative, et d'une manière plus générale de l'articulation entre politique régionale et autonomie communale [less ▲] Detailed reference viewed: 27 (3 ULg) |
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