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See detailFish consumption patterns and hair mercury levels in children and their mothers in 17 EU countries
Castano, Argelia; Cutanda, Francisco; Esteban, Marta et al

in Environmental Research (in press)

The toxicity of methylmercury (MeHg) in humans is well established and the main source of exposure is via the consumption of large marine fish and mammals. Of particular concern are the potential ... [more ▼]

The toxicity of methylmercury (MeHg) in humans is well established and the main source of exposure is via the consumption of large marine fish and mammals. Of particular concern are the potential neurodevelopmental effects of early life exposure to low-​levels of MeHg. Therefore, it is important that pregnant women, children and women of childbearing age are, as far as possible, protected from MeHg exposure. Within the European project DEMOCOPHES, we have analyzed mercury (Hg) in hair in 1799 mother-​child pairs from 17 European countries using a strictly harmonized protocol for mercury anal. Parallel, harmonized questionnaires on dietary habits provided information on consumption patterns of fish and marine products. After hierarchical cluster anal. of consumption habits of the mother-​child pairs, the DEMOCOPHES cohort can be classified into two branches of approx. similar size: one with high fish consumption (H) and another with low consumption (L)​. All countries have representatives in both branches, but Belgium, Denmark, Spain, Portugal and Sweden have twice as many or more mother-​child pairs in H than in L. For Switzerland, Czech Republic, Hungary, Poland, Romania, Slovenia and Slovakia the situation is the opposite, with more representatives in L than H. There is a strong correlation (r=0.72) in hair mercury concn. between the mother and child in the same family, which indicates that they have a similar exposure situation. The clustering of mother-​child pairs on basis of their fish consumption revealed some interesting patterns. One is that for the same sea fish consumption, other food items of marine origin, like seafood products or shellfish contribute significantly to the mercury levels in hair. We conclude that addnl. studies are needed to assess and quantify exposure to mercury from seafood products, in particular. The cluster anal. also showed that 95​% of mothers who consume once per wk fish only, and no other marine products, have mercury levels 0.55 μg​/g. Thus, the 95th percentile of the distribution in this group is only around half the US-​EPA recommended threshold of 1 μg​/g mercury in hair. Consumption of freshwater fish played a minor role in contributing to mercury exposure in the studied cohort. The DEMOCOPHES data shows that there are significant differences in MeHg exposure across the EU and that exposure is highly correlated with consumption of fish and marine products. Fish and marine products are key components of a healthy human diet and are important both traditionally and culturally in many parts of Europe. Therefore, the communication of the potential risks of mercury exposure needs to be carefully balanced to take into account traditional and cultural values as well as the potential health benefits from fish consumption. European harmonized human biomonitoring programs provide an addnl. dimension to national HMB programs and can assist national authorities to tailor mitigation and adaptation strategies (dietary advice, risk communication, etc.) to their country's specific requirements. [less ▲]

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See detailÉclairer les enjeux de la reconstruction industrielle du bassin liégeois : l'apport des archives des Etablissements insalubres et dangereux (1919-1925)
Peters, Arnaud ULg; Defechereux, Olivier ULg; Destatte, Julien ULg

in Parmentier, Isabelle (Ed.) Actes des Deuxièmes Rencontres d'Histoire de l'Environnement en Belgique (Belgique, Luxembourg, Congo, Rwanda, Burundi) (in press)

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See detailThe utility of Google Scholar when searching geographical literature: comparison with three commercial bibliographic databases
Stirbu, Simona ULg; Thirion, Paul ULg; Schmitz, Serge ULg et al

in Journal of Academic Librarianship (in press)

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science ... [more ▼]

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science (WoS) and FRANCIS (multidisciplinary databases) and GeoRef (specialized in geosciences). To ensure a valid comparison, identical bibliographic searches were applied using each of the four bibliographic tools. To exclude automatic variations of the ten keywords tested, they were placed between quotation marks and searched only in the “title” field of the respective search tools’ interfaces. The results were limited to bibliographic references published from 2005 to 2009. In order to assess the repeatability of the results, the exact same process was repeated monthly between November 2010 and July 2011. Initially the whole set of results was analyzed, after which the search results for two keywords (selected since they yielded a manageable number of results) were studied in more detail. The results indicate that GS search results show a large degree of overlap with those of the other databases but, moreover, yield numerous unique hits, which should be useful to researchers in both the fields of human and physical geography. GS leads the other tools widely on number of results, independently of keyword, subfield, year of publication, or time of search. [less ▲]

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See detailUsing kernels and ecological niche modelling to delineate conservation areas in an endangered patch-breeding phenotype
Denoël, Mathieu ULg; Ficetola, Francesco

in Ecological Applications (in press)

Efficient delineation of conservation areas is a great challenge in maintaining biodiversity. Kernel density estimators (KDEs) are a powerful tool in this perspective, but they have not been applied at ... [more ▼]

Efficient delineation of conservation areas is a great challenge in maintaining biodiversity. Kernel density estimators (KDEs) are a powerful tool in this perspective, but they have not been applied at the population level on patch-distributed organisms. This would be particularly worthy for species that need broad habitats beyond those where they can be sampled; such as terrestrial lands for pond-breeding amphibians. The aim of this study was to compare different approaches for the identification of suitable areas for conservation: KDE, ecological niche modelling, and a combination of KDE and niche models. Paedomorphosis was chosen as a model system because this is an important form of intraspecific variation that is present in numerous taxa, but geographically localized within species and globally endangered. 277 ponds were sampled in one of the hotspots of paedomorphosis to determine the abundance and distribution of paedomorphs (i.e. individuals retaining gills at the adult stage) of the palmate newt (Lissotriton helveticus), with emphasis on the connections between the most valuable populations. KDEs gave insights into the surface areas required to balance the maintenance of certain number of connected ponds and the respective number of disjoint areas in which the whole population is divided. The inclusion of barriers in the models helped in accurately designing the limits of the areas to protect. Alone, habitat models were not able to successfully delineate the area to protect, but the integration between terrestrial suitable areas or barriers and KDE allowed an objective identification of areas required for conservation. Overall, the best performance was observed by the KDE integrating ecological barriers, and by the combination between KDE and niche modelling. In a broader perspective, KDEs are thus a pertinent tool in providing quantitative spatial measurements to delineate conservation areas based on patch-abundance data with a specific focus to connectivity. [less ▲]

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See detailMoyens et enjeux d’une approche didactique des Illuminations
Saint-Amand, Denis ULg

in Parade Sauvage (in press), 25

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See detailTowards a framework for assessment and management of cumulative human impacts on marine food webs
Giakoumi, Sylvaine; Halpern, Benjamin S.; Michel, Loïc ULg et al

in Conservation Biology (in press)

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic ... [more ▼]

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic threats holistically, it is necessary to know how threats affect different components within ecosystems and ultimately alter ecosystem functioning. We used a case study of a Mediterranean seagrass (Posidonia oceanica) food web and expert knowledge elicitation in an application of the initial steps of a framework for assessment of cumulative human impacts on food webs. We produced a conceptual seagrass food web model, determined the main trophic relationships, identified the main threats to the food web components, and assessed the components’ vulnerability to those threats. Some threats had high (e.g., coastal infrastructure) or low impacts (e.g., agricultural runoff) on all food web components, whereas others (e.g., introduced carnivores) had very different impacts on each component. Partitioning the ecosystem into its components enabled us to identify threats previously overlooked and to reevaluate the importance of threats commonly perceived as major. By incorporating this understanding of system vulnerability with data on changes in the state of each threat (e.g., decreasing domestic pollution and increasing fishing) into a food web model, managers may be better able to estimate and predict cumulative human impacts on ecosystems and to prioritize conservation actions. [less ▲]

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See detailComments on the discordant recommendations for the use of symptomatic slow acting drugs in knee osteoarthritis.
Reginster, Jean-Yves ULg; Cooper, Cyrus; Hochberg, Marc et al

in Current medical research and opinion (in press)

Abstract Despite the near concurrent publication by influential scientific organizations, there are important differences in interpretation of the evidence base and the conclusions derived from the recent ... [more ▼]

Abstract Despite the near concurrent publication by influential scientific organizations, there are important differences in interpretation of the evidence base and the conclusions derived from the recent Osteoarthritis Research Society International (OARSI) guidelines for the management of knee osteoarthritis, the American College of Rheumatology (ACR) (concerning also hip and hand osteoarthritis) and the algorithm recommendations by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). This is particularly evident for the drug class of Symptomatic Slow-Acting Drugs in OsteoArthritis. In this paper, we highlight these differences and try to understand where they derive from, proposing an evidence-based interpretation. [less ▲]

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See detailLe Mur et le masque. À propos de Banksy.
Saint-Amand, Denis ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailA Parallel Processing Approach to Dynamic Simulations of Combined Transmission and Distribution Systems
Aristidou, Petros ULg; Van Cutsem, Thierry ULg

in International Journal of Electrical Power & Energy Systems (in press)

Simulating a power system with both transmission and distribution networks modeled in detail is a huge computational challenge. In this paper, a Schur-complement-based domain decomposition algorithm is ... [more ▼]

Simulating a power system with both transmission and distribution networks modeled in detail is a huge computational challenge. In this paper, a Schur-complement-based domain decomposition algorithm is proposed to provide accurate, detailed dynamic simulations of such systems. The simulation procedure is accelerated with the use of parallel programming techniques, taking advantage of the parallelization opportunities inherent to domain decomposition algorithms. The proposed algorithm is general, portable and scalable on inexpensive, shared-memory, multi-core machines. A large-scale test system is used for its performance evaluation. [less ▲]

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See detailÀ propos de l’écologie du discours heuristique
Job, Pierre ULg; Gilot, Marguerite ULg

in Actes du 4ième congrès international sur la théorie anthropologique du didactique (TAD) : Évolutions contemporaines du rapport aux mathématiques et aux autres savoirs à l'école et dans la société (in press)

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See detailInventer. Le jeune Descartes et les voies de l’inventio en 1619-1620
Dubouclez, Olivier ULg

in Savini, Massimiliano (Ed.) Les écrits de jeunesse de Descartes (in press)

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See detailImaginer-lire le Capital
Pieron, Julien ULg

in Cahiers d'Etudes Germaniques (in press)

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See detailDialectique de l’inattendu. Voies et impasses de la philosophie dans l’œuvre de Valère Novarina
Dubouclez, Olivier ULg

in Née, Laure (Ed.) Valère Novarina (in press)

Novarina entretient avec la philosophie une relation faite d’attraction et de défiance. Le primat accordé à la parole et le refus de toute ontologie le conduisent à définir un nouveau modèle théorique ... [more ▼]

Novarina entretient avec la philosophie une relation faite d’attraction et de défiance. Le primat accordé à la parole et le refus de toute ontologie le conduisent à définir un nouveau modèle théorique, celui de la « fugue » et, tout en poursuivant le dialogue avec les philosophes, à construire ce que nous appellerons une dialectique de l’inattendu, mouvement par lequel le vide actif qui habite la personne humaine nourrit le renouvellement de la pensée et de l’action. [less ▲]

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See detailSartre em psicologia clínica: situação, emoção e ultrapassando
Englebert, Jérôme ULg

in Ribeiro Scheider, Daniela; Gastal de Castro, Fernando; Bloc Boris, Georges (Eds.) Sartre e os desafios para a psicologia contemporânea (in press)

À travers ce chapitre, nous proposons de réaliser l’étude de différents apports de la philosophie de Jean-Paul Sartre à la réflexion et la pratique de la psychopathologie. La « psychopathologie de l’homme ... [more ▼]

À travers ce chapitre, nous proposons de réaliser l’étude de différents apports de la philosophie de Jean-Paul Sartre à la réflexion et la pratique de la psychopathologie. La « psychopathologie de l’homme en situation » qui s’esquisse repose sur la notion fondamentale de l’émotion ainsi que sur la possibilité de dépassement de cette situation. Ce moment fait jaillir une trame temporelle puisqu’il révèle à la fois l’histoire et la biographie du sujet, mais également son projet et dès lors les fulgurances de la liberté. Penser l’homme en situation, le savoir sorcier ou magicien (c’est-à-dire à la fois ému et émouvant) et parvenir à mobiliser sa narrativité sont des paris essentiels de l’œuvre de Sartre, que la psychopathologie, tant dans sa dimension théorique que pratique, ne peut ignorer. [less ▲]

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See detailHommage à Luc Collès
Defays, Jean-Marc ULg; Géron, Geneviève

Book published by Editions Modulaires Européennes (in press)

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See detailQu'est-ce qu'un indicateur ? Paradigme indiciaire et processus de gouvernementalité
Petteni, Oriane ULg

in Nicolas, Loic (Ed.) L'indice (in press)

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See detailWhat do Pneumocystis organisms tell us about the phylogeography of their hosts? The case of the woodmouse Apodemus sylvaticus in continental Europe and western Mediterranean islands
Demanche, christine; Deville, Manjula; Michaux, Johan ULg et al

in PLoS ONE (in press)

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the ... [more ▼]

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the presence and genetic diversity of Pneumocystis organisms was investigated in 203 lung samples from woodmice (Apodemus sylvaticus) collected on western continental Europe and Mediterranean islands. The presence of Pneumocystis DNA was assessed by nested PCR at both large and small mitochondrial subunit (mtLSU and mtSSU) rRNA loci. Direct sequencing of nested PCR products demonstrated a very high variability among woodmouse-derived Pneumocystis organisms with a total number of 30 distinct combined mtLSU and mtSSU sequence types. However, the genetic divergence among these sequence types was very low (up to 3.87%) and the presence of several Pneumocystis species within Apodemus sylvaticus was considered unlikely. The analysis of the genetic structure of woodmouse-derived Pneumocystis revealed two distinct groups. The first one comprised Pneumocystis from woodmice collected in continental Spain, France and Balearic islands. The second one included Pneumocystis from woodmice collected in continental Italy, Corsica and Sicily. These two genetic groups were in accordance with the two lineages currently described within the host species Apodemus sylvaticus. Pneumocystis organisms are emerging as powerful tools for phylogeographic studies in mammals [less ▲]

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See detailContribution of Revised International Prognostic Scoring System Cytogenetics to Predict Outcome After Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes: A Study From the Socie 0 te0 FranO´ aise de Greffe de Moelle et The 0 rapies Cellulaires
Gauthier, Jordan; Damaj, Gandhi; Langlois, Carole et al

in Transplantation (in press)

Background. The prognosis of myelodysplastic syndromes (MDS) after allogeneic stem cell transplantation is critically determined by cytogenetic abnormalities, as previously defined by International ... [more ▼]

Background. The prognosis of myelodysplastic syndromes (MDS) after allogeneic stem cell transplantation is critically determined by cytogenetic abnormalities, as previously defined by International Prognostic Scoring System (IPSS) cytogenetics. It has been shown that a new cytogenetic classification, included in the IPSS-R (cytogenetic-IPSS-R [C-IPSS-R]), can better predict the outcome of untreated MDS patients.Methods. In this study, we assessed the impact of the IPSS-R cytogenetic score (C-IPSS-R) on the outcome of 367 MDS patients transplanted from HLA-identical siblings or HLA allele-matched unrelated donors. Results. According to the C-IPSS-R, 178 patients (48%) fell in the good risk, 102 (28%) in the intermediate risk, 77 (21%) in the poor risk, and 10 (3%) in the very poor risk group. In multivariate analysis, after a median follow-up of 4 years, the poor and very poor-risk categories correlated with shorter overall survival (OS) (4-year OS, 32%; hazard ratio [HR], 1.59; P = 0.009 and OS, 10%; HR, 3.18; P = 0.002, respectively) and higher cumulative incidence of relapse (CIR) (CIR, 52%; HR, 1.82; P = 0.004 and CIR, 60%; HR, 2.44; P = 0.060, respectively). Conclusions. Overall, the C-IPSS-R changed the IPSS cytogenetic risk only in 8% of cases but identified a new risk group, the very poor C-IPSS-R category, with dismal outcome after allogeneic stem cell transplantation (10% 4-year OS, 60% 4-year CIR). Posttransplantation maintenance therapy should be investigated in prospective trials for patients with high-risk C-IPSS-R karyotypes. [less ▲]

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