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See detailTrifles for 'Unflemings'. Teaching Dutch Literary History in Nineteenth-Century Wallonia
Steyaert, Kris ULg

in Van Kalmthout, T.; Zuidervaart, H. (Eds.) The Practice of Philology in the Nineteenth-Century Netherlands (2015)

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See detailUpdate on the role of extracorporeal CO2 removal
MORIMONT, Philippe ULg; BATCHINSKY, Andriy; LAMBERMONT, Bernard ULg

in Critical Care (2015)

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found ... [more ▼]

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. [less ▲]

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See detailA Membrane-Type-1 Matrix Metalloproteinase (MT1-MMP) - Discoidin Domain Receptor 1 Axis Regulates Collagen-Induced Apoptosis in Breast Cancer Cells.
Assent, Delphine; Bourgot, Isabelle ULg; Hennuy, Benoît ULg et al

in PloS one (2015), 10(3), 0116006

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To ... [more ▼]

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel microenvironment. How cells interact with and respond to their microenvironment during cancer dissemination remains poorly understood. To address the impact of type I collagen on the fate of tumour cells, human breast carcinoma MCF-7 cells were cultured within three-dimensional type I collagen gels (3D COL1). Using this experimental model, we have previously demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP), a proteinase overexpressed in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis. Here we performed a transcriptomic analysis to decipher the molecular mechanisms regulating 3D COL1-induced apoptosis in human breast cancer cells. Control and MT1-MMP expressing MCF-7 cells were cultured on two-dimensional plastic plates or within 3D COL1 and a global transcriptional time-course analysis was performed. Shifting the cells from plastic plates to 3D COL1 activated a complex reprogramming of genes implicated in various biological processes. Bioinformatic analysis revealed a 3D COL1-mediated alteration of key cellular functions including apoptosis, cell proliferation, RNA processing and cytoskeleton remodelling. By using a panel of pharmacological inhibitors, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase specifically activated by collagen, as the initiator of 3D COL1-induced apoptosis. Our data support the concept that MT1-MMP contributes to the inactivation of the DDR1-BIK signalling axis through the cleavage of collagen fibres and/or the alteration of DDR1 receptor signalling unit, without triggering a drastic remodelling of the transcriptome of MCF-7 cells. [less ▲]

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See detailCharacterization of collagen fibrils after equine suspensory ligament injury: an ultrastructural and biochemical approach
Shikh Al Sook, Mohamad Khir ULg; Gabriel, Annick ULg; Salouci, Moustafa et al

in The Veterinary Journal (2015)

Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the fibril ... [more ▼]

Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the fibril morphology, as well as the collagen content and types. The purpose of this study was to evaluate, using biochemical and ultrastructural approaches, the alterations in collagen fibrils after injury. Eight Warmblood horses with visible signs of injury in only one forelimb SL were selected and specimens were examined by transmission electron microscope (TEM). Collagen types I, III and V were purified by differential salt precipitation after collagen extraction with acetic acid containing pepsin. TEM revealed abnormal organization as well as alterations in the diameter and shape of fibrils after SL injury. The bands corresponding to types I, III and V collagen were assessed by densitometry after sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Densitometric analysis indicated that the proportions of type III and type V collagen were significantly higher (P <0.001) in damaged tissues compared to normal tissues with a mean increase of 20.9 and 17.3% respectively. Concurrently, a significant decrease (P <0.001) in type I collagen within damaged tissues was recorded with a mean decrease of 15.2%. These alterations could be the hallmark of a decrease in the tissue quality and mechanical properties of the ligament. This provides new insight for subsequent research on tissue regeneration that may lead to the development of future treatment strategies for SL injury. [less ▲]

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See detailApprendre l'Histoire en faisant de l'histoire : Pie XII et la "Solution Finale"
Jadoulle, Jean-Louis ULg

in CORNET, Jacques; DARO, Sabine (Eds.) Voir double pour mieux comprendre. Outils didactiques pour la formation des enseignants en sciences et sciences humaines (2015)

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See detailFrom Alexander to the Theoi Adelphoi: Foundation and Legitimation of a Dynasty
Caneva, Stefano ULg

Book published by Peeters (2015)

This book provides a cultural and social history of the rise and legitimation of the concept of dynastic continuity in the early history of the Ptolemaic Empire. The scope of the study is therefore ... [more ▼]

This book provides a cultural and social history of the rise and legitimation of the concept of dynastic continuity in the early history of the Ptolemaic Empire. The scope of the study is therefore neither to provide a general overview of third-century Ptolemaic history, nor to discuss in detail the administrative and economic structures of the Ptolemaic state. Rather, its purpose is to investigate the ways by which the first Ptolemies negotiated and constructed a representation of their power as a dynastic house aspiring to universal dominion, protected by the gods and legitimately continuing the heritage of the Macedonian and Egyptian monarchies. It is argued that they managed to do so by operating within different socio-cultural and ethnic milieus and by pursuing their strategies on a two-fold level: on the one hand, by continuously reshaping the relationship between the present events of the ruling house and its historical and mythical past, so as to adapt it to new political and cultural agendas; on the other hand, by shifting the border between the spheres of human and divine power in order to ensure themselves the legitimacy and loyalty stemming from religious thought and practice. Discussed evidence comprises Greek and Egyptian sources, literary and documentary texts, iconographic and archaeological evidence from the Macedonian conquest of Egypt under Alexander to the ascension of Ptolemy III Euergetes. Whenever possible, a new, encompassing evaluation of old evidence has gained new impetus from the intensive analysis of newly published sources. Secondly, the complex cultural and social factors operating in the construction and legitimation of the Ptolemaic dynasty have been discussed by drawing on the contribution of up-to-date scholarship in cultural and religious history as well as in sociology. The rooting of Ptolemaic power in Egypt and the Eastern Mediterranean is studied as the movement from the immediate but unstable right of conquest established by Alexander, and subsequently claimed by the satrap Ptolemy, to the development of a mature and coherent system of power practices and representations. The structure of the book is meant to provide readers with a chronological and thematic discussion ranging from Alexander’s conquest of Egypt to the first years of Ptolemy III. However, the six chapters that constitute this study can also be read separately as they are conceived as the monographic treatment of major moments or aspects of the cultural, political, and religious history of the early Hellenistic period. Chapter 1 deals with the premises of Ptolemaic power in Egypt by focusing on the time of Alexander’s conquest. The implications of Alexander’s sonship to Zeus Ammon in propaganda and in religion are reviewed by drawing attention to the plurality of audiences (Macedonians, Greeks, Egyptians) for which this motif was conceived and used. Chapter 2 discusses the conflicting patterns of legitimation in the age of the Successors and how Ptolemy exploited them in his rise from satrap to king. Some seminal moments of Ptolemy’s career are re-examined: the acquisition of Alexander’s corpse as a source of embodied legitimacy; the interactions between the leader and pre-existing Macedonian and Egyptian elites as they appear in assembly scenes of Greek historiography and in the hieroglyphic Satrap stele; Ptolemy’s help to the Rhodians against Antigonus and Demetrius and the entanglement between royal charisma and religious honours. Chapter 3 focuses on the figure of Dionysus in Ptolemaic religion and culture from a twofold perspective. Firstly, the chapter provides an innovative analysis of the religious and ideological role of Dionysus in Ptolemy II’s Alexandrian procession described by Callixeinus of Rhodes. Secondly, it aims at offering a contribution for a reappraisal of the figure of Dionysus, of his cults and of the role of his figure within the larger context of the Ptolemaic Empire in the third century BC. Chapter 4 discusses the patterns of divinization of Arsinoe II within the royal couple through the most complete documentary dossier collected thus far on the subject. Rather than constituting the aim of the research, the debate concerning the chronology of Arsinoe’s death and divinization has provided the rough framework for a new investigation of how the image of a solid royal couple was invented and spread in religious life and in propaganda. Diachronic developments in the configurations of the dynastic couple are traced through Greek and Egyptian evidence and discussed in relation to the changing of political agendas during the reign of Ptolemy II. Chapter 5 studies the contribution of Ptolemy III to the construction of Ptolemaic dynastic continuity through old and new evidence, notably by providing fresh observations concerning the recently published decree of Alexandria (243 BC) for the understanding of Ptolemaic royal festivals in general and, more in particular, for the history of the festival Ptolemaia in the second half of the 3rd century BC. Chapter 6 breaks with chronological continuity to trace, through literary and documentary evidence from the Roman period, the development of the tradition envisaging Alexander’s body as a talismanic relic protecting the city of Alexandria. The purpose of this epilogue is to provide a methodological essay of interpretation of cultural traditions in the longue durée, when patterns of continuity developed under the Ptolemies were separated from their original context of diffusion and consequently were re-used to shape the civic identity of Alexandria within the new and broader framework of the Roman Empire. Although focus on the construction of a dynasty as a sequence of legitimate, kindred holders of monarchic power makes Ptolemaic kings and queens the central object of this study, it is argued that sovereigns cannot be considered as the sole holders of the initiative in the political, ideological and religious processes relating to the construction of royal and dynastic imagery. On the contrary, it appears that social agents other than the holders of supreme leadership not only reacted to top-down stimulation, but they also constructed, for their own use, representations of the monarchs that interacted with the message issued by the central power. From this perspective, therefore, dynastic continuity results from the intertextual combination of a variety of ideological and religious motifs stemming from different agents and occasions of communication. [less ▲]

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See detailBrefs propos sur le principe de la direction du litige
Paris, Catherine ULg

in Recueil de jurisprudence - Responsabilité - Assurances - Accidents du travail - Vol. III Jurisprudence 2013 (2015)

L'auteur examine, à la lumière d'un arrêt de la cour de cassation du 7 juin 2013, quelques hypothèses dans lesquelles l'assureur de la responsabilité a ou, au contraire, n'a pas, le droit de diriger le ... [more ▼]

L'auteur examine, à la lumière d'un arrêt de la cour de cassation du 7 juin 2013, quelques hypothèses dans lesquelles l'assureur de la responsabilité a ou, au contraire, n'a pas, le droit de diriger le litige qui oppose son assuré à la personne lésée. [less ▲]

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See detailEmisiones de NO en la mesosfera marciana: medidas y simulaciones
González-Galindo, F; López-Valverde, M.A.; Gagné, Marie-Eve et al

Conference (2015)

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See detailGenome-Wide Analysis of In Vivo Binding of the Master Regulator DasR in Streptomyces coelicolor Identifies Novel Non-Canonical Targets
Świątek-Połatyńska, MA; Bucca, G; Laing, E et al

in PLoS ONE (2015)

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See detailMetagenomic analysis of the bacterial microbiota linked to the traditional Algerian date product "Btana"
Abekhti, Abdelkader; Taminiau, Bernard ULg; Kihal, Mabrouk et al

in Annals of Microbiology (2015)

In this study, using high throughput pyrosequencing, we highlighted the bacterial diversity of the traditional Algerian date product "Btana" that is produced in southern Algeria using both direct (DBM ... [more ▼]

In this study, using high throughput pyrosequencing, we highlighted the bacterial diversity of the traditional Algerian date product "Btana" that is produced in southern Algeria using both direct (DBM) and indirect (UBM) methods. Metagenomic analysis yielded a total of 103,379 reads, with a 606 total operational taxonomic units (OTUs) detected. Firmicutes represented 84.79 % of the total pyrosequencing reads. Phylogenetic analysis revealed that the Bacillales represented 90.20 % ± 15.12 % of the total reads. Among the phylotypes detected, Bacillus was the dominant genus (39.53 %). While Bacillus megaterium was shared among all of the samples, its distribution varied widely. Non-metric multidimensional scaling (nMDS) analysis showed that UBM samples clustered together, and three main OTUs were found in these UBM samples: Paenibacillus polymyxa, Paenibacillus xylanexedens, and Planomicrobium JN082684. Correlation analysis showed no association between parametersof the samples (age, pH, water activity) and the specific microbiota. [less ▲]

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See detailEffect of metal ions and metal nanoparticles encapsulated in porous silica on biphenyl biodegradation by Rhodococcus erythropolis T902.1
Wannoussa, Wissal; Hiligsmann, Serge ULg; Tasseroul, Ludivine ULg et al

in Journal of Sol-Gel Science and Technology (2015)

Biodegradation of biphenyl was carried out by Rhodococcus erythropolis T902.1 in presence ofnanometer-sized metallic (Co, Pd, Ag and Cu) nanoparticles (NPS) synthesized by the sol-gel process. In order to ... [more ▼]

Biodegradation of biphenyl was carried out by Rhodococcus erythropolis T902.1 in presence ofnanometer-sized metallic (Co, Pd, Ag and Cu) nanoparticles (NPS) synthesized by the sol-gel process. In order to prevent their agglomeration, the metallic NPs (1-2 nm diameter) were anchored inside microporous silica crystallites and named Co/SiO2, Pd/SiO2, Ag/SiO2 and Cu/SiO2 samples respectively. They were added at low concentrations of 10-6 M, 10-5 M and 10-4 M of metal in the culture medium and their impact was compared with that of the simple metal ions added as cobalt, palladium, silver or copper salts. The cultures containing Pd/SiO2 or Co/SiO2 samples at 10-4 M of metal achieved a 50% higher biphenyl degradation yield after 18 days of incubation and improved Rhodococcus erythropolis T902.1 growth compared with those without (positive control) or with silica particles only. The highest biodegradation performance, i.e. 107 ±3 ppm/day, which was about 85% higher than in control conditions without NPs, was recorded in 250 ml baffled flasks stirred at 150 rpm with Co/SiO2 sample at 10-4 M Co. Furthermore, the stimulating effect of NPs on biphenyl biodegradation seems to also depend on the thermal treatment conditions applied to NPs since the experimental results indicated that, after calcination, the cobalt oxide NPs at a concentration of 10-4 M were more effective than the reduced cobalt NPs with a degradation yield of 81 ±1% and 77 ±2% respectively after 18 days. On the other hand, the results showed that the addition of 10-4 M of Cu2+ or Ag+ ions or the addition of Cu/SiO2 or Ag/SiO2 samples at 10-4 M of metal have an inhibitory effect on biphenyl biodegradation. However, Cu2+ and Ag+ ions were more toxic to the Rhodococcus erythropolis T902.1 bacteria than the respective Cu or Ag NPS anchored inside silica particles. Moreover, this work showed that in these conditions, the activity of catechol 1, 2-dioxygenase (a critical enzyme in aromatic biodegradation pathway) was severely inhibited, whereas the presence of 10-4 M of Co2+ ions or Co/SiO2 sample stimulated the enzyme activity compared to the conditions without NPs. [less ▲]

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See detailSimulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settings
Donneau, Anne-Françoise ULg; Mauer, Murielle; Lambert, Philippe ULg et al

in Journal of Biopharmaceutical Statistics (2015), 25(03), 570-601

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]

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See detailA method to search for large-scale concavities in asteroid shape models
Devogele, Maxime ULg; Rivet, Jean-Pierre; Tanga, Paolo et al

in Monthly Notices of the Royal Astronomical Society (2015)

Light curve inversion is proven to produce an unique model solution only under the hypothesis that the asteroid is convex. However, it was suggested that the resulting shape model, for the case of non ... [more ▼]

Light curve inversion is proven to produce an unique model solution only under the hypothesis that the asteroid is convex. However, it was suggested that the resulting shape model, for the case of non-convex asteroid, is the convex-hull of the true asteroid non-convex shape. While a convex shape is already useful to provide the overall aspect of the target, much information about real shapes is missed, as we know that asteroids are very irregular. It is a commonly accepted evidence that large flat areas sometimes appearing on shapes derived from light curves correspond to concave areas, but this information has not been further explored and exploited so far. We present in this paper a method that allows to predict the presence of concavities from such flat regions. This method analyzes the distribution of the local normals to the facets composing shape models to predict the presence of abnormally large flat surfaces. In order to test our approach, we consider here its application to a large family of synthetic asteroid shapes, and to real asteroids with large scale concavities, whose detailed shape is known by other kinds of observations (radar and spacecraft encounters). The method that we propose is proven to be reliable and capable of providing a qualitative indication of the relevance of concavities on well-constrained asteroid shapes derived from purely photometric data sets. [less ▲]

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See detailLe "Gate fever" : cristallisation et fossilisation de l’univers carcéral
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2015), 4

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See detailDans les limites de l'intervention psycho-éducative: quelle désistance possible ?
Glowacz, Fabienne ULg

in Bihain, Luc (Ed.) Protection de la Jeunesse. 50 ans, le temps de la maturité et des réformes (2015)

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See detailHydromechanical modelling of shaft sealing for CO2 storage
Dieudonné, Anne-Catherine ULg; Cerfontaine, Benjamin ULg; Collin, Frédéric ULg et al

in Engineering Geology (2015), 193

The geological sequestration of CO2 in abandoned coal mines is a promising option to mitigate climate changes while providing sustainable use of the underground cavities. In order to certify the ... [more ▼]

The geological sequestration of CO2 in abandoned coal mines is a promising option to mitigate climate changes while providing sustainable use of the underground cavities. In order to certify the efficiency of the storage, it is essential to understand the behaviour of the shaft sealing system. The paper presents a numerical analysis of CO2 transfer mechanisms through a mine shaft and its sealing system. Different mechanisms for CO2 leakage are considered, namely multiphase flow through the different materials and flow along the interfaces between the lining and the host rock. The study focuses on the abandoned coal mine of Anderlues, Belgium, which was used for seasonal storage of natural gas. A two-dimensional hydromechanical modelling of the storage site is performed and CO2 injection into the coal mine is simulated. Model predictions for a period of 500 years are presented and discussed with attention. The role and influence of the interface between the host rock and the concrete lining are examined. In addition the impact of some uncertain model parameters on the overall performance of the sealing system is analysed through a sensitivity analysis. [less ▲]

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See detailL'équivalence entre "mental" et "conscient" chez Brentano
Seron, Denis ULg

in Gyemant, Maria; Popa, Delia (Eds.) Approches phénoménologiques de l'inconscient (2015)

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See detailLes Grottes d'Azé: contexte géologique et encaissant calcaire jurassique
Dechamps, Sylvain ULg; Boulvain, Frédéric ULg; Barriquand, Lionel et al

Book published by Département de Saône-et-Loire (2015)

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See detailDiachronical soil surveys: a way to quantify long term diffuse erosion
Pineux, Nathalie ULg; Michel, Brieuc ULg; Legrain, Xavier ULg et al

in Geophysical Research Abstracts (2015), 17

The loess belt of Western Europe is a high-risk area regarding diffuse erosion. It is due to the climate and the topography but also to the soil type. Loamy soils are naturally highly sensitive to diffuse ... [more ▼]

The loess belt of Western Europe is a high-risk area regarding diffuse erosion. It is due to the climate and the topography but also to the soil type. Loamy soils are naturally highly sensitive to diffuse erosion. Hence, these soils are very fertile. So, they are intensively cultivated which increases their sensitivity to erosion. Sheet erosion is an erosion type strongly represented in these regions. Contrarily to the concentrated form of erosion which happens more brutally, sheet erosion needs long-term observation time-scales, which remains rare. In Belgium, a soil map was established in 1956. This map is quite detailed and notably informs about the different horizons which are in the profile (ploughed horizon, eluvial horizon, clay included between the horizons, carbonate-free loess horizon, and all these were characterised by drainage class) and their depth. It was based on a dense augering network across the country (one point every 75 meters). A new augering campaign was done again in 2014. It consisted in one observation every 50 meters on an agricultural watershed of 124 hectares located in the centre of Belgium. This catchment has been cultivated since the 14th century and is representative of the local context (gentle slope (3-8%), plot size (mean value of 10 ha), …). We compared the two soil maps produced on this site with a 58years time lapse. Results show that the large majority of the watershed falls from upslope soils with weak erosion to slope soils with strong erosion. The soil thickness diminished in some zones to 1m10 (minimum estimation) of erosion. This comparison shows that very few upslope soils are preserved. On the other hand, the areas where colluviums were present to the full depth stay at the same place in the main thalweg of the watershed. Other areas on the watershed seem to be subject to a (minimum estimation) of 40cm of sediments deposition. Large areas in the watershed suffered from erosion and came to deposition areas as the clay horizon is no longer observed under the colluviums. It can be highlighted that soil depths were worryingly lost during 58 years of tillage and that some soils were converted to colluviums which is of lower agronomical quality than the original soils which had a clay horizon below to keep water. Diachronical soil survey offers an unique insight of long term diffuse erosion and should demonstrate the importance of preserving soils even in regions where agricultural yields are not (yet) affected by erosion. [less ▲]

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