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See detailInterviews sur la rénovation du stock bâti en Belgique
Ruellan, Guirec ULg

Report (2016)

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See detailMultidisciplinary management of breast cancer
Leclerc, Anne-France ULg; JERUSALEM, Guy ULg; DEVOS, Martine ULg et al

in Archives of Public Health (2016), 74

Breast cancer, with an increasing incidence, is the most frequently diagnosed cancer in women worldwide. The treatments proposed, generally a combination of surgery, radiotherapy, chemotherapy, endocrine ... [more ▼]

Breast cancer, with an increasing incidence, is the most frequently diagnosed cancer in women worldwide. The treatments proposed, generally a combination of surgery, radiotherapy, chemotherapy, endocrine therapy and / or targeted therapy, are constantly improving, allowing a reduction in the mortality rate, but they are still causing many side effects, not only early but also late, which leads us to consider the post-cancer period as a chronic condition. Side effects, reviewed in this commentary, may affect physical functions, psychological status, social situation, body composition, well-being and quality of life of the patient. In view of the extent of these areas in which side effects of breast cancer and of its treatments can be found, the supportive care offered at the end of treatment need to be multidisciplinary. Different supportive care interventions may be proposed to the patients such as psychological and behavioral interventions, complementary therapies, diet interventions, physical activity/rehabilitation or also physiotherapy interventions for example, all having shown some beneficial effects in the literature. The benefits of these supportive care interventions are thereby already established and they are described in this article, but others studies will be needed to clearly define indications and most optimal modalities of application to reduce side effects and improve quality of life of patients. [less ▲]

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See detailEnjeux méthodologiques dans un contexte de rémission en oncologie pédiatrique: triangulation entre le médecin, sa famille et le patient
Vander Haegen, Marie ULg; Etienne, Anne-Marie ULg

in De l'expertise scientifique à l'expertise profane: Postures, enjeux et méthodes dans le champs de la psychologie de la santé (2016, December)

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See detailThe added value of new GNSS for ionosphere monitoring
Warnant, René ULg; Deprez, Cécile ULg

in Proceedings of Navitec 2016 (2016, December)

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See detailNEW INJECTABLE LIPOSOME AND DRUG-IN-CYCLODEXTRIN-IN LIPOSOME SYSTEMS ENCAPSULATING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES
Palazzo, Claudio ULg; Laloy, Julie; Delvigne, Anne-Sophie et al

Poster (2016, December)

Purpose: In 2010, almost 15 million of babies in the world are prematurely borned, 11.1 % of the total amount of alive children. Despite the better neonatology techniques, the number of preterm babies ... [more ▼]

Purpose: In 2010, almost 15 million of babies in the world are prematurely borned, 11.1 % of the total amount of alive children. Despite the better neonatology techniques, the number of preterm babies with motor, vision, hearing or mental deficiencies is still constant along the last twenty years. Moreover, no efficacy treatment is available to the present day. The estetrol (E4) has an important role in the brain development and protection. The aim of this study is to develop new injectable liposome and drug-in-cyclodextrin-in-liposome (DCL) formulations, encapsulating E4 in order to enhance its crossing through the blood-brain barrier (BBB). Methods: Cyclodextrins (CD) were used to increase E4 aqueous solubility. Liposome and DCL (E4-CD complex) formulations were prepared by thin-film hydration technique. The formulations were physicochemical characterized. LDH and MTS tests on endothelial, neuronal and BBB model cells were performed in vitro on the liposome formulation. Hemocompatibility of the formulations was evaluated on red blood cells, platelet aggregation and coagulation. BBB passage tests were performed using human BBB cell line (hCMEC/D3). Results: E4-CD complexes proportionally increased the solubility of the hormone. Liposomes and DCL encapsulating E4 were prepared. All the formulations had average particle size below 150 nm, polydispersity index below 0.10 and ζ potential around + 30 mV. The encapsulation efficacy for liposomes was between 3% and 10% while those of DCL are between 15% and 35%. Moreover, the formulations are capable to release 80 % (liposome) and 90 % (DCL) of encapsulated E4 after 3 h at 37°C. The effect of liposome and DCL formulations on cell viability and integrity was evaluated. The results showed no toxic effects on all the tested cell lines. Hemocompatibility tests showed no hemolysis, platelet aggregation or effects on coagulation, confirming the possibility of the formulations to be intravenously administrated. BBB passage tests highlighted the capability of the formulations to pass the BBB and reach the brain. Conclusions: New non-toxic, hemocompatible liposome and DCL formulations encapsulating E4 were prepared. The formulations are promising drug delivery system to target estrogens to the brain, due to their physiochemical characteristics. [less ▲]

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See detailEvolution récente des surface forestières et de la régénération des coupes rases en Wallonie
Latte, Nicolas ULg; Perin, Jérôme ULg; Lejeune, Philippe ULg

in FORÊT.NATURE (2016), 141

Une gestion réfléchie de la ressource forestière à l’échelle d’une région, telle que la Wallonie, nécessite de connaitre son état et de prédire son devenir. Pour y parvenir, nous proposons une méthode ... [more ▼]

Une gestion réfléchie de la ressource forestière à l’échelle d’une région, telle que la Wallonie, nécessite de connaitre son état et de prédire son devenir. Pour y parvenir, nous proposons une méthode relativement simple, combinant trois sources de données : l’inventaire forestier régional, la photo-interprétation d’orthoimages et une enquête de terrain, ayant comme finalité de décrire finement l’évolution des surfaces forestières, les peuplements mis à blanc et la régénération des coupes rases. [less ▲]

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See detailPractical aspects of gene regulatory inference via conditional inference forests from expression data
Bessonov, Kyrylo ULg; Van Steen, Kristel ULg

in Genetic Epidemiology (2016)

Gene regulatory network (GRN) inference is an active area of research that facilitates understanding the complex interplays between biological molecules. We propose a novel framework to create such GRNs ... [more ▼]

Gene regulatory network (GRN) inference is an active area of research that facilitates understanding the complex interplays between biological molecules. We propose a novel framework to create such GRNs, based on Conditional Inference Forests (CIFs) as proposed by Strobl et al. Our framework consists of using ensembles of Conditional Inference Trees (CITs) and selecting an appropriate aggregation scheme for variant selection prior to network construction. We show on synthetic microarray data that taking the original implementation of CIFs with conditional permutation scheme (CIFcond) may lead to improved performance compared to Breiman's implementation of Random Forests (RF). Among all newly introduced CIF-based methods and five network scenarios obtained from the DREAM4 challenge, CIFcond performed best. Networks derived from well-tuned CIFs, obtained by simply averaging P-values over tree ensembles (CIFmean) are particularly attractive, because they combine adequate performance with computational efficiency. Moreover, thresholds for variable selection are based on significance levels for P-values and, hence, do not need to be tuned. From a practical point of view, our extensive simulations show the potential advantages of CIFmean-based methods. Although more work is needed to improve on speed, especially when fully exploiting the advantages of CITs in the context of heterogeneous and correlated data, we have shown that CIF methodology can be flexibly inserted in a framework to infer biological interactions. Notably, we confirmed biologically relevant interaction between IL2RA and FOXP1, linked to the IL-2 signaling pathway and to type 1 diabetes. [less ▲]

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See detailDonner son corps à la science. Progrès de la Médecine et apprentissage des médecins.
Bonnet, Pierre ULg

Learning material (2016)

Cours du cycle de l'Espace Universitaire de Liège 2016-17, Module Sciences et Avenir, cycle 1

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See detailGuide du chercheur américaniste à Brown University, Providence, Rhode Island, USA
Dauphin, Jean-Christophe ULg

in Nuevo Mundo Nuevos Mundos (2016)

Guide pratique destiné aux chercheurs américanistes.

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See detailThe Martian diffuse aurora: Monte Carlo simulations and comparison with IUVS-MAVEN observations
Gérard, Jean-Claude ULg; Soret, Lauriane ULg; Schneider, N. et al

Conference (2016, December)

A new type of Martian aurora, characterized by an extended spatial distribution, an altitude lower than the discrete aurora and electron precipitation up to 200 keV has been observed following solar ... [more ▼]

A new type of Martian aurora, characterized by an extended spatial distribution, an altitude lower than the discrete aurora and electron precipitation up to 200 keV has been observed following solar activity on several occasions with the IUVS on board the MAVEN spacecraft. We describe the results of Monte Carlo simulations of the production of several ultraviolet and visible auroral emissions for initial electron energies from 0.1 to 200 keV. These include the CO2+ ultraviolet doublet (UVD) at 288.3 and 289.6 nm and the Fox–Duffendack–Barker (FDB) bands, CO Cameron and Fourth Positive bands, OI 130.4 and 297.2 nm and CI 156.1 nm and 165.7 nm multiplets. We calculate the nadir and limb intensities of several of these emissions for a unit precipitated energy flux. Our results indicate that electrons in the range 100-200 keV produce maximum CO2+ UVD emission near 75 km. We combine SWEA and SEP electron energy spectra measured during diffuse aurora to calculate the volume emission rates and compare with IUVS observations of the emission limb profiles. The strongest predicted emissions are the CO2+ FDB, UVD and the CO Cameron bands. The metastable a 3Π state which radiates the Cameron bands is deactivated by collisions below ~110 km. As a consequence, we show that the CO2+ UVD to the Cameron bands ratio increases at low altitude in the energetic diffuse aurora. [less ▲]

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See detailA Rhynie Chert plant out of the Rhynie Chert
Cascales-Miñana, Borja ULg; Gerrienne, Philippe ULg

Conference (2016, December)

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See detailThe "graptolite hypothesis" or how to turn a palaeobotanical evidence into a scientific puzzle
Gerrienne, Philippe ULg; Tinn, Oive; Versteegh, Gerard et al

Conference (2016, December)

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See detailRelationships between environmental parameters and the microbenthic loop of Posidonia oceanica meadows at small spatial scale
Pete, Dorothée ULg; Alvera Azcarate, Aida ULg; Gobert, Sylvie ULg

in Zoology 2016: 23rd Congress of Zoology (2016, December)

In these times of global change, understanding how carbon flows through ecosystems is of primary importance. In coastal Mediterranean regions, Posidonia oceanica meadows produce and store a lot of carbon ... [more ▼]

In these times of global change, understanding how carbon flows through ecosystems is of primary importance. In coastal Mediterranean regions, Posidonia oceanica meadows produce and store a lot of carbon, but most of it is described as refractory. As a step in the understanding of how organic matter degradation/storage happens in this ecosystem, this study focus on small scale relationships between the microbenthic loop (organic matter, microphytobenthos, bacteria and meiofauna) and environmental parameters (grain size, P. oceanica density, vegetal fibre biomass, pore water nutrient content, sediment total carbon (TC), organic carbon (TOC), nitrogen (TN) and phosphorous (TP) contents, phaeopigments and bacterial production (FDC)). Thus, a 1.25 m x 1.25 m frame was put in a pristine P. oceanica meadow and twelve points were randomly sampled in May 2008 for all the studied parameters. At such a small scale, every component of the microbenthic loop presented a heterogeneity, which was the highest for the microphytobenthos biomass and the lowest for total meiofauna abundance (TMA). No relationship was found between the components of the microbenthic loop but the abundances of Turbellaria and Ciliophora were correlated with total organic matter in the sediment (TOM). None of the environmental parameter was linked with the microphytobenthos biomass, suggesting that the high spatial variability observed did not depend on the measured parameters. Relationships were found between TOM and ammonium, total bacteria abundance and biomass (TBA and TBB) and sediment phaeopigments, TMA and TC, TN and TP. TBB variability was however explained by a combination of FDC and nutrient contents in pore water and sediment. Taking the microbenthic loop as a whole, pore water ammonium and nitrites + nitrates, FDC and phaeopigments were able to explain the observed variability. So, at small scale the variability in the microbenthic loop of a P. oceanica meadow is related with parameters linked with degradation processes and bacteria activities (phaeopigments, FDC, ammonium, nitrites + nitrates), except for meiofauna, which is related with the nutrient content of the sediment, especially TC. Those results underline the importance of the relationship between the microbenthic loop and degradation processes, even at a small scale. [less ▲]

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See detailGC×GC-(HR)TOFMS : Why we Love it !
Focant, Jean-François ULg

Scientific conference (2016, December)

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See detailWhen obtaining a blood sample from the right arm was not the right thing to do: a case of elevated parathyroid hormone levels 27 years after thyroidectomy.
Wolff, Fleur; Gervy, Christine; Cavalier, Etienne ULg et al

in Clinical Chemistry & Laboratory Medicine (2016)

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See detailQui a peur du style en sociologie de la littérature ?
Stienon, Valérie ULg; Dessy, Clément; van Nuijs, Laurence

in COnTEXTES : Revue de Sociologie de la Littérature (2016), 18

Une certaine idée romantique du style a contribué, depuis le début du XIXe siècle, à développer une conception singularisante du style, qui associe celui-ci à l'expression d'une originalité de l'individu ... [more ▼]

Une certaine idée romantique du style a contribué, depuis le début du XIXe siècle, à développer une conception singularisante du style, qui associe celui-ci à l'expression d'une originalité de l'individu écrivant. Que faire alors de cette conception de la singularité en sociologie de la littérature, discipline qui privilégie l’explication par le collectif et s’attache à situer chaque pratique dans le tout social ? Comment retrouver les traces de l’individu social dans la matière verbale ou la trace écrite qu’il produit ? L’expression et la saisie d’une subjectivité, censées être le propre du style, sont-elles objectivables ? Dans quelle mesure les styles peuvent-ils rencontrer les dynamiques collectives ? Cet article propose un état de la question et quelques pistes méthodologiques à la lumière des approches sociales du littéraire. [less ▲]

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See detailFirst-principles reinvestigation of bulk WO3
Hamdi, Hanen ULg; Salje, Ekhard K. H.; Ghosez, Philippe ULg et al

in Physical Review B (2016), 94

Using first-principles calculations, we analyze the structural properties of tungsten trioxide WO3. Our calculations rely on density functional theory and the use of the B1-WC hybrid functional, which ... [more ▼]

Using first-principles calculations, we analyze the structural properties of tungsten trioxide WO3. Our calculations rely on density functional theory and the use of the B1-WC hybrid functional, which provides very good agreement with experimental data. We show that the hypothetical high-symmetry cubic reference structure combines several ferroelectric and antiferrodistortive (antipolar cation motions, rotations, and tilts of oxygen octahedra) structural instabilities. Although the ferroelectric instability is the largest, the instability related to antipolar W motions combines with those associated to oxygen rotations and tilts to produce the biggest energy reduction, yielding a P21/c ground state. This nonpolar P21/c phase is only different from the experimentally reported P c ground state by the absence of a very tiny additional ferroelectric distortion. The calculations performed on a stoichiometric compound so suggest that the low-temperature phase of WO3 is not intrinsically ferroelectric and that the experimentally observed ferroelectric character might arise from extrinsic defects such as oxygen vacancies. Independently, we also identify never observed R3m and R3c ferroelectric metastable phases with large polarizations and low energies close to the P 21 /c ground state, which makes WO3 a potential antiferroelectric material. The relative stability of various phases is discussed in terms of the anharmonic couplings between different structural distortions, highlighting a very complex interplay. [less ▲]

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See detailVoir en art, voir en sciences
Dondero, Maria Giulia ULg

in Nouvelle Revue d'Esthétique (2016), 17(1), 139-159

This article is about visual devices that in history of art and in semiotics are generally called "metavisual" and that are used to study some phenomena of framing in artistic images (see the works of ... [more ▼]

This article is about visual devices that in history of art and in semiotics are generally called "metavisual" and that are used to study some phenomena of framing in artistic images (see the works of Victor Stoichita and of Jean-François Bordron). We are going to explore the possibility to use these devices to analyse contemporary scientific images, trying to identify some common actions that go beyond the differences in terms of objects and economy of values between arts and sciences. [less ▲]

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See detailApproche du régime alimentaire chez le Silure glane
Libois, Roland ULg; Rosoux, René; Gabris, Bruno

in Recherches Naturalistes en Région Centre (2016), 3 N.S.

The Wels originates from central and East-Europe. It was introduced in Europe as early as the Middle Ages and in France the species has been released many times since the 19th century. It invaded the ... [more ▼]

The Wels originates from central and East-Europe. It was introduced in Europe as early as the Middle Ages and in France the species has been released many times since the 19th century. It invaded the Loire river basin at the end of the last century. It is the largest predatory freshwater fish in Europe. Considering its recent increase in numbers and of range and its feeding behaviour, the Orleans museum coordinated a study of the species in the Loire valley from 2011 to 2014 in order to better know the species ecology and especially its choice of prey and food intake. The stomach contents from a sample of 60 individuals of all sizes, captured using nets, were analysed. It feeds on a wide variety of species, more than 23 were found during this study, mainly fish. Anadromous Fish and Lamprey made up an important part of the food intake (66%). [less ▲]

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