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See detailLe parc scientifique du Sart Tilman, "Liege Science Park"
Merenne-Schoumaker, Bernadette ULg

in Pierre Geurts, Caroline Lamarche (Ed.) Dérivations 2 Pour le débat urbain (2016)

L'article retrace l'histoire du parc scientifique de Liège et tente d'en montrer les impacts sur le redéploiement régional. Il cherche aussi à développer une réflexion sur le concept de parc scientifique ... [more ▼]

L'article retrace l'histoire du parc scientifique de Liège et tente d'en montrer les impacts sur le redéploiement régional. Il cherche aussi à développer une réflexion sur le concept de parc scientifique, ses liens avec la recherche ainsi que les enjeux et défis liés au futur du tout parc de ce genre [less ▲]

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See detailSouthern Blues Night , Heerlen (Hollande) 19 mars 2016
Sacré, Robert ULg

E-print/Working paper (2016)

Compte rendu de la Southern Blues Night annuelle de Heerlen aux Pays Bas, avec photos

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See detailNewborn screening for sickle cell disease : 13 years at the CHR "La Citadelle", Liège
Sepulchre, Edith; Ketelslegers, Olivier; Minon, Jean-Marc et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2016, March), 18(1), 107

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See detailAzacytidine Enhances Regulatory T-Cells In Vivo and Prevents Experimental Xenogeneic Graft-Versus-Host Disease
Ehx, Grégory ULg; Fransolet, Gilles ULg; de Leval, Laurence ULg et al

in Biology of Blood and Marrow Transplantation (2016, March), 22(3), 393

Background. The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 ... [more ▼]

Background. The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Tregs). Objective. We investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) in a humanized murine model of transplantation, and described the impact of the drug on human T cells in vivo. Methods. In order to induce xGVHD, human peripheral blood mononuclear cells (huPBMC) were administered intravenously in NOD-scid IL-2Rγnull (NSG) mice. Results. AZA successfully improved both survival (p<0.0001) and xGVHD scores (p<0.0001). Further, AZA significantly decreased human T-cell proliferation as well as INF-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA administration significantly increased the function, proliferation and frequency of Tregs through demethylation of FOXP3i1 and higher secretion of IL-2 by conventional T cells due to IL2 gene promoter site 1 demethylation. Interestingly, among AZA-treated mice surviving the acute phase of xGVHD, there was an inverse correlation between the presence of Tregs and signs of chronic GVHD. Finally, Tregs harvested from the spleen of AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Conclusion. These findings emphasize a potential role for AZA as prevention or treatment of GVHD and other autoimmune diseases. [less ▲]

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See detailProgressive Current Source Models in Magnetic Vector Potential Finite-Element Formulations
Dular, Patrick ULg; Kuo-Peng, Patrick; Ferreira da Luz, Mauricio V. et al

in IEEE Transactions on Magnetics (2016), 52(3),

Progressive refinements of the current sources in magnetic vector potential finite-element (FE) formulations are done with a subproblem method. The sources are first considered through magnetomotive force ... [more ▼]

Progressive refinements of the current sources in magnetic vector potential finite-element (FE) formulations are done with a subproblem method. The sources are first considered through magnetomotive force or Biot–Savart models up to their volume FE models, from statics to dynamics. A novel way to define the source fields is proposed to lighten the computational efforts, through the conversion of the common volume sources to surface sources, without the need for any preresolution. Accuracy improvements can then be obtained for local currents and fields, and global quantities, i.e., inductances, resistances, Joule losses, and forces. [less ▲]

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See detailComputation of Source for Non-Meshed Coils in a Reduced Domain with A–V Formulation
Ferrouillat, Pauline; Guérin, Christophe; Meunier, Gérard et al

in IEEE Transactions on Magnetics (2016), 52(3),

The discretized source magnetic vector potential Aj, projected from source field Hs with H(curl,Ω) semi-norm, is studied for non-meshed coils with magnetic vector potential A and electric scalar potential ... [more ▼]

The discretized source magnetic vector potential Aj, projected from source field Hs with H(curl,Ω) semi-norm, is studied for non-meshed coils with magnetic vector potential A and electric scalar potential V formulation. As a novelty, source potential Aj is computed in a reduced domain Ωred instead of the complete domain Ω. For domains with fixed and moving parts, potential Aj can be computed on each part, for each of the related current sources, with no need to ensure its continuity between these parts. [less ▲]

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See detailFinite-Element Homogenization of Laminated Iron Cores With Inclusion of Net Circulating Currents Due to Imperfect Insulation
Gyselinck, Johan; Dular, Patrick ULg; Krähenbühl, Laurent et al

in IEEE Transactions on Magnetics (2016), 52(3),

This paper deals with the time-domain homogenization of laminated cores in 2-D or 3-D finite-element (FE) models of electromagnetic devices, allowing for net circulating current in the laminations (e.g ... [more ▼]

This paper deals with the time-domain homogenization of laminated cores in 2-D or 3-D finite-element (FE) models of electromagnetic devices, allowing for net circulating current in the laminations (e.g., due to imperfect or damaged insulation). The homogenization is based on the expansion of the induction throughout the lamination thickness using a set of orthogonal polynomial basis functions (BFs), in conjunction with the magnetic vector potential formulation. These BFs allow for net flux, net current, and skin effect in the laminations; by choosing the number of BFs, one can compromise between accuracy and computational cost. The approach is validated through a linear 2-D test case with in-plane imposed and induced current density. A brute-force model, in which all laminations are finely meshed, produces the reference solution. The extension to nonlinear 3-D problems is expected to be straightforward. [less ▲]

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See detailDesign Sensitivity Analysis for Shape Optimization of Nonlinear Magnetostatic Systems
Kuci, Erin ULg; Henrotte, François; Duysinx, Pierre ULg et al

in IEEE Transactions on Magnetics (2016), 52(3),

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative ... [more ▼]

The paper discusses the sensitivity analysis for the shape optimization of a nonlinear magnetostatic system, evaluated both by direct and adjoint approaches. The calculations rely on the Lie derivative concept of differential geometry where the flow is the velocity field associated with the modification of a geometrical parameter in the model. The resulting sensitivity formulas can be expressed naturally in a finite element setting through a volume integral in the layer of elements connected to the surface undergoing shape modification. The accuracy of the methodology is analyzed on a 2D model of an interior permanent magnet motor (IPM), and on a 3D model of a permanent magnet system. [less ▲]

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See detailComparison of Nonlinear Domain Decomposition Schemes for Coupled Electromechanical Problems
Halbach, Alexandre ULg; Dular, Patrick ULg; Geuzaine, Christophe ULg

in IEEE Transactions on Magnetics (2016), 52(3),

The aim of this paper is to compare several domain decomposition schemes for nonlinear, coupled electromechanical problems. Both staggered and monolithic electrostatic/elastic formulations are considered ... [more ▼]

The aim of this paper is to compare several domain decomposition schemes for nonlinear, coupled electromechanical problems. Both staggered and monolithic electrostatic/elastic formulations are considered for the multiphysics problem. The domain decomposition is applied either to a single multiphysics iteration, which corresponds to a linear problem, or to the full nonlinear multiphysics resolution. In the latter, the problem solved at each domain decomposition iteration is nonlinear. The influence of the elastic wave’s frequency and the electrostatic potential on the convergence rate and the computational cost of the algorithm is investigated on a 2-D model of a vibrating micromembrane array. [less ▲]

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See detailLa ville en Djézireh syrienne au Bronze Ancien
Mas, Juliette ULg

Scientific conference (2016, March)

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See detailPhenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity
Verstraelen,, Sandra; Peers, Bernard ULg; Maho, w et al

in Journal of Applied Toxicology (2016)

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See detailOrigin of emission from square-shaped organic microlasers
Dubertrand, Rémy ULg

in Europhysics Letters [=EPL] (2016), 113

The emission from open cavities with non-integrable features remains a challenging problem of practical as well as fundamental relevance. Square-shaped dielectric microcavities provide a favorable case ... [more ▼]

The emission from open cavities with non-integrable features remains a challenging problem of practical as well as fundamental relevance. Square-shaped dielectric microcavities provide a favorable case study with generic implications for other polygonal resonators. We report on a joint experimental and theoretical study of square-shaped organic microlasers exhibiting a far-field emission that is strongly concentrated in the directions parallel to the side walls of the cavity. A semiclassical model for the far-field distributions is developed that is in agreement with even fine features of the experimental findings. Comparison of the model calculations with the experimental data allows the precise identification of the lasing modes and their emission mechanisms, providing strong support for a physically intuitive ray-dynamical interpretation. Special attention is paid to the role of diffraction and the finite side length. [less ▲]

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See detailLe médicament du mois. Le dulaglutide (Trulicity®) : Nouvel agoniste des récepteurs du Glucagon-Like Peptide-1 en injection hebdomadaire pour traiter le diabète de type 2
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : Dulaglutide (Trulicity®) is a new once-weekly agonist of Glucagon-Like Peptide-1 (GLP-1) receptors indicated in the treatment of type 2 diabetes. Phase III clinical trials in AWARD programme ... [more ▼]

Summary : Dulaglutide (Trulicity®) is a new once-weekly agonist of Glucagon-Like Peptide-1 (GLP-1) receptors indicated in the treatment of type 2 diabetes. Phase III clinical trials in AWARD programme demonstrated the efficacy and safety of dulaglutide in patients with type 2 diabetes treated by diet and exercise, metformin, a combination of metformin and a sulfonylurea or metformin and pioglitazone or even by supplements of prandial insulin. In the AWARD programme, dulaglutide (subcutaneous 0.75 or 1.5 mg once weekly) exerted a greater glucose-lowering activity than metformin, sitagliptin, exenatide or insulin glargine, and was non-inferior to liraglutide 1.8 mg once daily. Dulaglutide is currently reimbursed in Belgium after failure of and in combination with a dual oral therapy with metformin and a sulfonylurea or metformin and pioglitazone. [less ▲]

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See detail2nd International Conference, Architecture & Philosophy: AT THE TURN OF THE EXPERIENCE, questioning what we build, sharing what we face
YOUNES, Chris; BONNAUD, Xavier; Bodart, Céline ULg et al

Scientific conference (2016, March)

The conference is an initiative of the GERPHAU lab, research group for Philosophy, Architecture, Urban (Architecture School of Paris La Villette, UMR 7218 CNRS-Lavue), in partnership with Cité de l ... [more ▼]

The conference is an initiative of the GERPHAU lab, research group for Philosophy, Architecture, Urban (Architecture School of Paris La Villette, UMR 7218 CNRS-Lavue), in partnership with Cité de l'Architecture et du Patrimoine and philAU (a scientific thematic network : Philosophy, Architecture, Urban). This conference is also supported by ARENA(Architectural Research in Europe Network Association), a shared platform that aims to promote, support, develop and disseminate high-quality research in all fields of architecture in the widest sense. The proposal of the conference AT THE TURN OF THE EXPERIENCE is to start with the hypothesis that the architecture could be conceive as a way of enquiring on this new experience of the world. Because it provides precisely access to the experience modalities of the building world, we argue that it could in return reveal such a processing paradigm shift in the making of human settlements. We invite to re-invest and re-question its representation apparatus that it used to deploy on territories in order to translate in fictions and projects what these ones could become. To discuss about these apparatus just as such these possible translations, the conference is addressed to all researchers and practitioners, architects and creators, the experienced ones and the experiencing ones as well, whose works attempt to question what we build and to share what we face. [less ▲]

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See detailLa vignette diagnostique de l’étudiant. L’importance du facteur temps et de la chronologie des événements dans l’anamnèse médicale
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails ... [more ▼]

Summary : Medical history taking represents a key step in the diagnostic approach. A structured interview with a special attention to the chronology of events is mandatory. The medical student often fails to use the information on time in an optimal way. The aim of this article is to draw the attention on a few key elements, especially the age of the patient, the duration of symptoms, the time of occurrence of complaints within the 24h period and, finally, how to interpret the simultaneous or sequential occurrence of two (or more) events. [less ▲]

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See detailLes Comic strips oubliés par l'histoire
Maresca, Peter; Crucifix, Benoît ULg

Article for general public (2016)

Traduction d'un court essai de Peter Maresca, éditeur de Sunday Press Books

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See detailÉditorial=Woord vooraf
Decoster, Sara ULg

in Cahiers de la Documentation = Bladen voor Documentatie (2016), 70

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See detailCarbon dioxide and vegetable oil for the synthesis of bio-based polymer precursors, theoretical study of the organocatalyzed synthesis of non-isocyanate polyurethanes
Alves, Margot ULg; Jérôme, Christine ULg; Tassaing, Thierry

Conference (2016, March)

Non-isocyanate polyurethanes (NIPUs) represent a green alternative to the classical synthesis route of polyurethanes involving toxic isocyanates. This “greener” approach based upon renewable feedstocks ... [more ▼]

Non-isocyanate polyurethanes (NIPUs) represent a green alternative to the classical synthesis route of polyurethanes involving toxic isocyanates. This “greener” approach based upon renewable feedstocks and carbon dioxide consists in a two-step reaction. In a first step, carbonated vegetable oils are obtained using an appropriate catalyst by the chemical fixation of CO2 onto vegetable oils formerly epoxidized. Finally, the ring-opening polymerization (ROP) of the carbonated vegetable oil by a diamine provides hydroxy urethanes. In this las step, some organocatalysts have been recently proposed that allows achieving good conversion rates in particular in the case of aromatic diamines. However, the activation mechanism of these organocatalysts is not fully elucidated. In this context, the aim of the present project relies on the theoretical study of a model reaction using DFT calculations. Bicyclic guanidine based catalysts, 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 7-methyl-TBD (MTBD), were investigated as catalysts for the reaction between propylene carbonate and aliphatic or aromatic amines. The structural ability of TBD to simultaneously give and receive protons was highlighted by the detailed mechanism investigation. The bifunctional activity of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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