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See detailClinical trials of new drugs for the treatment of rheumatoid arthritis: focus on early disease
SMOLEN, J.S.; COLLAUD BASSET, S.; BOERS, M. et al

in Annals of Rheumatic Diseases (2016)

The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases convened a task force of experts in rheumatoid arthritis (RA) and clinical trial methodology to comment on the new draft ‘Guideline on clinical investigation of medicinal products for the treatment of RA’ released by the European Medicines Agency (EMA). Special emphasis was placed by the group on the development of new drugs for the treatment of early RA. In the absence of a clear definition of early RA, it was suggested that clinical investigations in this condition were conducted in disease-modifying antirheumatic drugs naïve patients with no more than 1 year disease duration. The expert group recommended using an appropriate improvement in disease activity (American College of Rheumatology (ACR) or Simplified/Clinical Disease Activity Index (SDAI/CDAI) response criteria) or low disease activity (by any score) as primary endpoints, with ACR/European League Against Rheumatism remission as a secondary endpoint. Finally, as compelling evidence showed that the Disease Acrivity Score using 28-joint counts (DAS28) might not provide a reliable definition of remission, or sometimes even low disease activity, the group suggested replacing DAS28 as a measurement instrument to evaluate disease activity in RA clinical trials. Proposed alternatives included SDAI, CDAI and Boolean criteria. [less ▲]

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See detailSynthesis of hydrophilic CuInS2/ZnS quantum dots with different polymeric shells and study of their cytotoxicity and hemocompatibility
Speranskaya, Elena Sergeevna; Sevrin, Chantal ULg; De Saeger, Sarah et al

in ACS Applied Materials and Interfaces (2016)

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See detailGrowth hormone releasing hormone excess and blockade in X-LAG syndrome.
Daly, Adrian Francis ULg; Lysy, Philippe; Defilles, Celine et al

in Endocrine-related cancer (2016)

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and ... [more ▼]

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GH-releasing hormone (GHRH) levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(D-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. [less ▲]

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See detailInfluence of a long-term storage in anaerobic conditions on Norway spruce (Picea abies, L. Karst.) physical and mechanical wood properties
Riguelle, Simon ULg; Lesire, Cécile ULg; Hebert, Jacques ULg et al

in Wood Material Science & Engineering (2016)

Timber storage is a key aspect of storm damage management. After huge storms, sprinkling storage is usually the most used conservation process but anaerobic storage in sealed silos appears as good ... [more ▼]

Timber storage is a key aspect of storm damage management. After huge storms, sprinkling storage is usually the most used conservation process but anaerobic storage in sealed silos appears as good alternative to preserve wood quality over long periods. This paper investigates the impact of long-term (57 months) storage of Norway spruce logs in anaerobic atmosphere on wood properties. Tests were performed on clear wood specimens and on lumbers to determine the modulus of elasticity (E), the static bending strength (σf) and the dynamic bending strength (K). Storage effects on impregnability and colour variation were also studied. Results show no effect of storage on E, σf and K. The naturally poor impregnability of Norway spruce is not improved by the anaerobic conditions, compared to traditional wet storage. Triangle tests reveal no discernible colour variation between logs that underwent anaerobic storage and the control sample. As a conclusion, despite a mould (Gliocladium solani) frequently observed on logs surface after the storage, the process offers ideal conservation conditions. While overall cost remains the main drawback for using anaerobic storage at large scale, the process can be recommended for high value logs, especially since it has few environmental impacts. [less ▲]

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See detailFormulation of a 1D finite element of heat exchanger for accurate modelling of the grouting behaviour: Application to cyclic thermal loading
Cerfontaine, Benjamin ULg; Radioti, Georgia ULg; Collin, Frédéric ULg et al

in Renewable Energy : An International Journal (2016), 96

This paper presents a comprehensive formulation of a finite element for the modelling of borehole heat exchangers. This work focuses on the accurate modelling of the grouting and the field of temperature ... [more ▼]

This paper presents a comprehensive formulation of a finite element for the modelling of borehole heat exchangers. This work focuses on the accurate modelling of the grouting and the field of temperature near a single borehole. Therefore the grouting of the BHE is explicitly modelled. The purpose of this work is to provide tools necessary to the further modelling of thermo-mechanical couplings. The finite element discretises the classical governing equation of advection-diffusion of heat within a 1D pipe connected to ground nodes. Petrov-Galerkin weighting functions are used to avoid numerical disturbances. The formulation is able to capture highly transient and steady-state phenomena. The proposed finite element is validated with respect to analytical solutions. An example consisting of a 100 m depth U-pipe is finally simulated. A first continuous heating simulation highlights the nonsymmetric distribution of temperature inside and near the borehole. An estimation of the error on the results as a function of the resolution parameters is also carried out. Finally simulations of cyclic thermal loading exhibit the need to take into account all daily variations if the grouting behaviour must be modelled. This is true especially in case of freeze-thaw damaging risk. [less ▲]

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See detailLearning of interval and general type-2 fuzzy logic systems using simulated annealing: Theory and practice
Almaraashi, Majid; John, Robert; Hopgood, Adrian ULg et al

in Information Sciences (2016)

This paper reports the use of simulated annealing to design more efficient fuzzy logic systems to model problems with associated uncertainties. Simulated annealing is used within this work as a method for ... [more ▼]

This paper reports the use of simulated annealing to design more efficient fuzzy logic systems to model problems with associated uncertainties. Simulated annealing is used within this work as a method for learning the best configurations of interval and general type-2 fuzzy logic systems to maximize their modeling ability. The combination of simulated annealing with these models is presented in the modeling of four benchmark problems including real-world problems. The type-2 fuzzy logic system models are compared in their ability to model uncertainties associated with these problems. Issues related to this combination between simulated annealing and fuzzy logic systems, including type-2 fuzzy logic systems, are discussed. The results demonstrate that learning the third dimension in type-2 fuzzy sets with a deterministic defuzzifier can add more capability to modeling than interval type-2 fuzzy logic systems. This finding can be seen as an important advance in type-2 fuzzy logic systems research and should increase the level of interest in the modeling applications of general type-2 fuzzy logic systems, despite their greater computational load. [less ▲]

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See detailEntorse de cheville
Kaux, Jean-François ULg

Learning material (2016)

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See detailStein's method for comparison of univariate distributions
Swan, Yvik ULg; Reinert, Gesine; Leys, Christophe

E-print/Working paper (2016)

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See detailBispecial factors in the Brun S-adic system
Labbé, Sébastien ULg; Leroy, Julien ULg

E-print/Working paper (2016)

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See detailAssessment of methods of detection of water estrogenicity for their use as monitoring tools in a process of estrogenicity removal
Blavier; Songulashvili; Simon, Coraline ULg et al

in Environmental Technology (2016)

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See detailLe couplage « Micro-crédit, Micro-assurance santé et Offre des soins » peut améliorer l’accessibilité aux soins de santé de qualité en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Médecine et Santé Tropicales (2015), 25

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in ... [more ▼]

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in Kinshasa. The bivariate analysis shows a significant association between the increase in purchasing power and realization of benefit (p = 0, 001), achievement of benefit and savings (p = 0, 000) savings and insurance health and improved access to health care: according to the main results, 68.8 %t of borrowers reported an increase in their purchasing power which 81.8% making benefit. Those with savings were 24.7 times more likely to contribute to a health insurance scheme than those without; 71.9% of those who have regularly contributed to health insurance have improved their access to care. Coupling microcredit, health microinsurance and health care can improve access to quality health care at lower cost. This suggests the integration of health insurance in the primary health care system. [less ▲]

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See detailLe droit constitutionnel de la Principauté de Liège au 18e siècle
Behrendt, Christian ULg; Vandenbosch, Sofia ULg

in Revue Belge de Droit Constitutionnel [= RBDC] (2015), 2015

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See detailUn moment machiavélien dans la théorie. Sur Althusser
Oulc'hen, Hervé ULg

in Cahiers du GRM (2015), 8

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See detailFurther insights into the metamorphosis process in a carapid fish
Parmentier, Eric ULg

in Journal of Zoology (2015)

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See detailCirculating microRNA-based screening tool for breast cancer
Freres, Pierre ULg; Wenric, Stéphane ULg; Boukerroucha, Meriem et al

in Oncotarget (2015)

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative ... [more ▼]

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis. A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors. A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. The accuracy of the diagnostic tool remained unchanged considering age and tumor stage. The miRNA signature correctly identified patients with metastatic breast cancer. The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group. Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. [less ▲]

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See detailIdentification d’indicateurs de la transition forestière en lien avec les impacts de la déforestation sur les socio-écosystèmes en Afrique centrale
Gillet, Pauline ULg; Vermeulen, Cédric ULg

Poster (2015, December 26)

La théorie de la transition forestière lie l’évolution du couvert forestier au temps (Mather, 1992). Dans la première phase, le couvert forestier est très dense. Il diminue ensuite avec l’augmentation de ... [more ▼]

La théorie de la transition forestière lie l’évolution du couvert forestier au temps (Mather, 1992). Dans la première phase, le couvert forestier est très dense. Il diminue ensuite avec l’augmentation de la densité de population qui pratique la défriche pour la production agricole et utilise le bois pour répondre aux besoins en énergie et en bois d’œuvre. Dans un troisième temps, l’économie se spécialise, l’agriculture s’intensifie et est pratiquée sur les terres les plus productives et le rôle de l’écosystème forestier dans l’économie diminue. L’abandon des terres les moins productives permet la recolonisation forestière visible sur la courbe de transition. La présente étude tente d’identifier et de proposer des indicateurs d’occupation spatiale permettant, sur base d’images de télédétection, de prévoir la position réelle d’un site sur la courbe de transition forestière. Ensuite, l’étude des socio-écosystèmes en lien avec la transition forestière permet de démontrer l’impact de la diminution du couvert forestier sur le fonctionnement des sociétés humaines. Nous nous sommes penchés sur différents aspects caractérisant les activités des populations locales dans trois sites d’étude situés sur un gradient de déforestation en Afrique centrale tels que la composition de repas et l’origine des aliments. On observe que la déforestation induit une diminution des composants issus des activités fortement liées à l’écosystème telles que la chasse, la pêche ou la collecte au profit de l’agriculture et de l’élevage. [less ▲]

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