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See detailHot-Melt Extrusion as a Continuous Manufacturing Process to Form Ternary Cyclodextrin Inclusion Complexes
Thiry, Justine ULg; Krier, Fabrice; Ratwatte, Shenelka et al

Poster (2016, November 16)

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See detailDifferent and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Poster (2016, November 16)

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are ... [more ▼]

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells. We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. : We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

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See detailBelgian political situation
Verjans, Pierre ULg

Conference given outside the academic context (2016)

Belgian trends show that centrifugal move from the North of the country can lead to a separation or to a new form of federalism/confederalism.

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See detailLe Kimbanguisme et le prophétisme kongo : la tradition messianique dans la religion kongo / Kimbanguism and Kongo Prophetism : Messianic Tradition in Kongo Religion
Melice, Anne ULg; Sarró, Ramon

in Du Jourdain au Congo – Art et christianisme en Afrique centrale (2016)

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See detailIncreased Risk of Group B Streptococcus Invasive Infection in HIV-Exposed but Uninfected Infants: A Review of the Evidence and Possible Mechanisms.
DAUBY, Nicolas; CHAMEKH, Mustapha; MELIN, Pierrette ULg et al

in Frontiers in Immunology (2016), 7

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are ... [more ▼]

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are at increased risk of infectious morbidity, as compared to HIV-unexposed uninfected infants (HUU). A higher susceptibility to GBS infections has been reported in HEU infants, particularly late-onset diseases and more severe manifestations of GBS diseases. We review here the possible explanations for increased susceptibility to GBS infection. Maternal GBS colonization during pregnancy is a major risk factor for early-onset GBS invasive disease, but colonization rates are not higher in HIV-infected compared to HIV-uninfected pregnant women, while selective colonization with more virulent strains in HIV-infected women is suggested in some studies. Lower serotype-speci c GBS maternal antibody transfer and quantitative and qualitative defects of innate immune responses in HEU infants may play a role in the increased risk of GBS invasive disease. The impact of maternal antiretroviral treatment and its consequences on immune activation in HEU newborns are important to study. Maternal immunization presents a promising intervention to reduce GBS burden in the growing HEU population. [less ▲]

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See detailInterpellations impossibles. Question à Judith Butler
Borotto, Jessica ULg

Conference (2016, November 16)

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See detailLes débuts du Gravettien dans le Nord-Ouest de l’Europe (28.000-26.000 BP)
Touzé, Olivier ULg

Scientific conference (2016, November 16)

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See detailSang de cordon état des lieux et perspectives
BAUDOUX, Etienne ULg

Conference (2016, November 16)

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See detailVieillir en bonne santé dans nos sociétés actuelles …?
Adam, Stéphane ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 19 (0 ULg)
See detailRapport sur l'Habilitation de Catherine GUYON : Par la roue de sainte Catherine. Dévots, pèlerins et pèlerinage à sainte Catherine d’Alexandrie (VIIIe- début du XVIe siècle)
George, Philippe ULg

Report (2016)

Madame Guyon a étudié le culte de sainte Catherine d'Alexandrie et son développement tous azimuts.

Detailed reference viewed: 57 (1 ULg)
See detailPotential Antimalarials from Tropical Plants and Natural Products
Frederich, Michel ULg; Ledoux, Allison ULg

Scientific conference (2016, November 16)

Malaria is caused by Plasmodium, a protozoan parasite transmitted by anopheles mosquitoes, and was responsible for 438 000 deaths worldwide in 2015 according to the last World Malaria report.1 The ... [more ▼]

Malaria is caused by Plasmodium, a protozoan parasite transmitted by anopheles mosquitoes, and was responsible for 438 000 deaths worldwide in 2015 according to the last World Malaria report.1 The resistance of parasites to available and affordable medicines has become a widespread problem in exposed countries, making the search of new antimalarial compounds still necessary. As the immeasurable therapeutic potential of plants is well established2, natural products could be an interesting source of new antimalarial drugs. Indeed, according Newmann and Cragg, more than 60% of the antiparasitic drugs discovered between 1981 and 2014 were unaltered naturals products (12.5%), natural products derivatives (31.3%) and synthetic drugs with a natural product pharmacophore (18.8%).3 Then, the pharmacological and phytochemical study of plants, especially from traditional pharmacopoeias can be of first interest to discovered new antimalarial compound and also to valorize the traditional knowledge. The first part of the talk will concern some examples of results obtained in the lab : the in vivo activity of strychnogucine B, which was isolated from strychnos icaja and semi-synthetized, the optimization of ellagic acid as a lead in the treatment of malaria and the validation of MIT from Mezoneuron benthamianum. In the second part of the talk, the work about Poupartia borbonica, an endemic plant from Reunion Island studied in the framework of a collaboration with the University of Reunion Island will be presented. [less ▲]

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See detailOptimizing the subwavelength grating of L-band annular groove phase masks for high coronagraphic performance
Vargas Catalán, E.; Huby, Elsa ULg; Forsberg, P. et al

in Astronomy and Astrophysics (2016), 595

Context. The annular groove phase mask (AGPM) is one possible implementation of the vector vortex coronagraph, where the helical phase ramp is produced by a concentric subwavelength grating. For several ... [more ▼]

Context. The annular groove phase mask (AGPM) is one possible implementation of the vector vortex coronagraph, where the helical phase ramp is produced by a concentric subwavelength grating. For several years, we have been manufacturing AGPMs by etching gratings into synthetic diamond substrates using inductively coupled plasma etching. <BR /> Aims: We aim to design, fabricate, optimize, and evaluate new L-band AGPMs that reach the highest possible coronagraphic performance, for applications in current and forthcoming infrared high-contrast imagers. <BR /> Methods: Rigorous coupled wave analysis (RCWA) is used for designing the subwavelength grating of the phase mask. Coronagraphic performance evaluation is performed on a dedicated optical test bench. The experimental results of the performance evaluation are then used to accurately determine the actual profile of the fabricated gratings, based on RCWA modeling. <BR /> Results: The AGPM coronagraphic performance is very sensitive to small errors in etch depth and grating profile. Most of the fabricated components therefore show moderate performance in terms of starlight rejection (a few 100:1 in the best cases). Here we present new processes for re-etching the fabricated components in order to optimize the parameters of the grating and hence significantly increase their coronagraphic performance. Starlight rejection up to 1000:1 is demonstrated in a broadband L filter on the coronagraphic test bench, which corresponds to a raw contrast of about 10[SUP]-5[/SUP] at two resolution elements from the star for a perfect input wave front on a circular, unobstructed aperture. <BR /> Conclusions: Thanks to their exquisite performance, our latest L-band AGPMs are good candidates for installation in state of the art and future high-contrast thermal infrared imagers, such as METIS for the E-ELT. [less ▲]

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See detailThe BCCM/ULC collection to conserve the biodiversity and study the secondary metabolites of Polar cyanobacteria
Lara, Yannick ULg; Durieu, Benoit ULg; Renard, Marine ULg et al

Poster (2016, November 16)

In the Polar Regions, Cyanobacteria are the key primary producers and main drivers of the food webs in a wide range of aquatic to terrestrial habitats. For example, they build benthic microbial mats in ... [more ▼]

In the Polar Regions, Cyanobacteria are the key primary producers and main drivers of the food webs in a wide range of aquatic to terrestrial habitats. For example, they build benthic microbial mats in lakes and soil crusts. Their success in these harsh cold conditions can probably be explained by particular adaptations to survive freeze/thaw cycles, seasonally contrasted light intensities, high UV radiations, dessication and other environmental stresses. The BCCM/ULC public collection is funded by the Belgian Science Policy Office since 2011. It has obtained the ISO9001 certification for deposition and distribution of strains, as part of the multi-site certification for the BCCM consortium. This collection aims to gather a representative portion of the polar cyanobacterial diversity with different ecological origins (limnetic mats, soil crusts, cryoconites, endoliths,….) and make it available for researchers to study the taxonomy, evolution, adaptations to harsh environmental conditions, pigments, and genomic make-up. It presently includes 226 cyanobacterial strains, of which 119 are of Antarctic origin (catalogue: http://bccm.belspo.be/catalogues/ulc-catalogue-search). As shown by morphological identification, the strains belong to five orders (Synechococcales, Oscillatoriales, Pleurocapsales, Chroococcidiopsidales and Nostocales). The 16S rRNA and ITS sequences of the strains are being characterized. The first 85 Antarctic strains already studied are distributed into 25 Operational Taxonomic Units (OTUs = groups of sequences with > 97,5% 16S rRNA similarity), and thus, represent a quite large diversity. Moreover, strains identified as members of the genera Leptolyngbya or Phormidium appear in several lineages. This supports the idea that there is a need to revise the taxonomy of these polyphyletic genera with a simple filamentous morphology. To better understand the functioning, metabolism and adaptative strategies of cyanobacteria in the extreme Antarctic environment, the genome sequencing of 11 strains has been started. Pair-read data from illumina MiSeq runs were obtained and submitted to a bioinformatic pipeline dedicated to the assembly of genomes and search of sequences involved in the biosynthesis of secondary metabolites. Gene cluster prediction analysis allowed to characterize 20 clusters of NRPS, PKS and hybrid NRPS-PKS from 2 to 66kb. Surprisingly, none of the characterized operons had previously been described in the literature. [less ▲]

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See detailShear banding simulation in clay rock around an underground opening, and its contact mechanism with the gallery’s lining
Charlier, Robert ULg; Salehnia, Fatemeh ULg

in Proc. 5th International conference on geotechnical engineering and soil mechanics (2016, November 15)

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See detailSensitivity of the annual net ecosystem exchange to the cospectral model used for high frequency loss corrections at a grazed grassland site
Mamadou, Ossenatou; Gourlez de la Motte, Louis ULg; De Ligne, Anne ULg et al

in Agricultural and Forest Meteorology (2016), 228-229

Detailed reference viewed: 34 (8 ULg)
See detailLe journal des apprentissages : écrire et interagir pour mieux apprendre
Scheepers, Caroline ULg

Conference given outside the academic context (2016)

La formation est destinée aux enseignants du cycle 2 qui travaillent dans les établissements classés ZEP de Sarcelles. Elle vise à leur expliciter les fondements et modalités du journal des apprentissages ... [more ▼]

La formation est destinée aux enseignants du cycle 2 qui travaillent dans les établissements classés ZEP de Sarcelles. Elle vise à leur expliciter les fondements et modalités du journal des apprentissages que tiennent des élèves de primaire ou de secondaire. [less ▲]

Detailed reference viewed: 22 (1 ULg)
See detailFaut-il enseigner l'histoire de manière plus classique ?
Jadoulle, Jean-Louis ULg

Article for general public (2016)

Detailed reference viewed: 24 (1 ULg)