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See detailTowards a real time release approach for manufacturing tablets using NIR spectroscopy
Pestieau, Aude ULg; Krier, Fabrice ULg; Thoorens, Grégory et al

Poster (2014, June)

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See detailSorting of crop residues and fossil bones from soil by NIR Hyperspectral Imaging
Vincke, Damien; Eylenbosch, Damien ULg; Fernández Pierna, Juan Antonio et al

Conference (2014, June)

The scope of this paper is to present two applications using Near Infrared Hyperspectral Imaging (NIR-HSI) combined with chemometrics to sort constituents of soil and assess their qualitative parameters ... [more ▼]

The scope of this paper is to present two applications using Near Infrared Hyperspectral Imaging (NIR-HSI) combined with chemometrics to sort constituents of soil and assess their qualitative parameters. In the first application, the feasibility of using NIR-HSI to sort crop residues such as roots and straws in soil has been demonstrated. In the second application the potential of such instrumentation and method to assess the level of collagen preservation in fossil bones has been proved. [less ▲]

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See detailStereoselective synthesis of peptidoglycan fragments on solid support
Simon, Justine ULg; Lamborelle, Nicolas ULg; Joris, Bernard ULg et al

Poster (2014, June)

The mammalian proteins, Nod1 and Nod2, are able to recognize peptidoglycan motifs during bacterial infection. Interestingly, Nod1 is a detector of peptides and muropeptides containing the meso-2,6 ... [more ▼]

The mammalian proteins, Nod1 and Nod2, are able to recognize peptidoglycan motifs during bacterial infection. Interestingly, Nod1 is a detector of peptides and muropeptides containing the meso-2,6-diaminopimelic acid (m-A2pm), a non-proteinogenic amino acid found in Gram- bacteria. In this work, we describe a synthesis of peptidoglycan motifs entirely on solid support. Solid-Phase Peptide Synthesis (SPPS), Cross Metathesis (CM) and sugar chemistry are three methods to anchor respectively amino acids, m-A2pm and sugars derivatives on a resin as solid support. [less ▲]

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See detailPosterior Cingulate Cortex-Related Co-Activation Patterns: A Resting State fMRI Study in Propofol-Induced Loss of Consciousness
Amico, Enrico ULg; Gomez, Francisco; Di Perri, Carol et al

in PLoS ONE (2014), 9

Background: Recent studies have been shown that functional connectivity of cerebral areas is not a static phenomenon, but exhibits spontaneous fluctuations over time. There is evidence that fluctuating ... [more ▼]

Background: Recent studies have been shown that functional connectivity of cerebral areas is not a static phenomenon, but exhibits spontaneous fluctuations over time. There is evidence that fluctuating connectivity is an intrinsic phenomenon of brain dynamics that persists during anesthesia. Lately, point process analysis applied on functional data has revealed that much of the information regarding brain connectivity is contained in a fraction of critical time points of a resting state dataset. In the present study we want to extend this methodology for the investigation of resting state fMRI spatial pattern changes during propofol-induced modulation of consciousness, with the aim of extracting new insights on brain networks consciousness-dependent fluctuations. Methods: Resting-state fMRI volumes on 18 healthy subjects were acquired in four clinical states during propofol injection: wakefulness, sedation, unconsciousness, and recovery. The dataset was reduced to a spatio-temporal point process by selecting time points in the Posterior Cingulate Cortex (PCC) at which the signal is higher than a given threshold (i.e., BOLD intensity above 1 standard deviation). Spatial clustering on the PCC time frames extracted was then performed (number of clusters = 8), to obtain 8 different PCC co-activation patterns (CAPs) for each level of consciousness. Results: The current analysis shows that the core of the PCC-CAPs throughout consciousness modulation seems to be preserved. Nonetheless, this methodology enables to differentiate region-specific propofol-induced reductions in PCC-CAPs, some of them already present in the functional connectivity literature (e.g., disconnections of the prefrontal cortex, thalamus, auditory cortex), some others new (e.g., reduced co-activation in motor cortex and visual area). Conclusion: In conclusion, our results indicate that the employed methodology can help in improving and refining the characterization of local functional changes in the brain associated to propofol-induced modulation of consciousness. [less ▲]

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See detailAnalysis versus synthesis for trending of gas-path measurement time series
Borguet, Sébastien ULg; Léonard, Olivier ULg; Dewallef, Pierre ULg

in Proceedings of ASME Turbo Expo 2014 (2014, June)

Gas-path measurements used to assess the health condition of an engine are corrupted by noise. Generally, a data cleaning step occurs before proceeding with fault detection and isolation. Classical linear ... [more ▼]

Gas-path measurements used to assess the health condition of an engine are corrupted by noise. Generally, a data cleaning step occurs before proceeding with fault detection and isolation. Classical linear filters such as the exponentially weighted moving average filter are traditionally used for noise removal. Unfortunately, these low-pass filters distort trend shifts indicative of faults, which increases the detection delay. The present paper investigates two new approaches to non-linear filtering of time series. On one hand, the synthesis approach reconstructs the signal as a combination of elementary signals chosen from a pre-defined library. On the other hand, the analysis approach imposes a constraint on the shape of the signal (e.g., piecewise constant). Both approaches incorporate prior information about the signal in a different way, but they lead to trend filters that are very capable at noise removal while preserving at the same time sharp edges in the signal. This is highlighted through the comparison with a classical linear filter on a batch of synthetic data representative of typical engine fault profiles. [less ▲]

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See detailÉtude des changements de circulation au-dessus de l'océan Austral en été
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Camberlin, Pierre; Richard, Yves (Eds.) Actes du XXVIIème colloque de l'Association de Climatologie - Climat : système & interactions (2014, June)

Over the five last decades, the reanalyses (ERA and NCEP/NCAR) show a strengthening of the pressure gradient between the southern hemisphere subtropical anticyclone belt and the southern circumpolar lows ... [more ▼]

Over the five last decades, the reanalyses (ERA and NCEP/NCAR) show a strengthening of the pressure gradient between the southern hemisphere subtropical anticyclone belt and the southern circumpolar lows during summer. With the help of an automatic circulation type classification, we show that the strengthening of the pressure gradient is generalised to all circulation types and, paradoxically, it does not cause circulation changes. It is probably implied by the strengthening of the temperature gradient between the tropics and the South Pole, without consequences on the general circulation. Our classification also allows a successful comparison between the two reanalyses in a region where the observation data are rare. [less ▲]

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See detailLe "péril jaune" en RDC : mythe ou réalité ?
Wintgens, Sophie ULg; Kabamba, Bob ULg

in Santander, Sébastian (Ed.) L’Afrique, nouveau terrain de jeu des émergents (2014)

L’influence de la Chine en république démocratique du Congo (RDC) se caractérise par son caractère tardif mais fulgurant, au regard d’une présence chinoise historiquement forte en Afrique subsaharienne ... [more ▼]

L’influence de la Chine en république démocratique du Congo (RDC) se caractérise par son caractère tardif mais fulgurant, au regard d’une présence chinoise historiquement forte en Afrique subsaharienne. Son implantation offensive en RDC résulte d’une convergence d’intérêts entre un État chinois en quête de matières premières et de terres arables pour assurer son développement économique et sa stabilité politique, et un État congolais en (re)construction résolument acquis, depuis l’élection du président Joseph Kabila, au modèle de développement chinois fondé sur la séparation volontaire entre objectifs économiques et réformes politiques (prêts inconditionnés, aide déliée). En consacrant l’accroissement rapide des relations commerciales sino-congolaises, le partenariat stratégique Chine-Afrique, scellé en 2006 lors du troisième Forum de coopération sino-africain, participe plus largement de la remise en cause du rôle des puissances traditionnellement influentes dans la région. Au-delà de la concurrence économique induite vis-à-vis des États-Unis, du Japon et des institutions financières internationales au sein desquelles elle est largement représentée, l’Europe assiste plus singulièrement à la remise en question de son leadership régional et à la dépréciation normative de sa politique développementale. Entre émancipation et hégémonie, cet article vise à mettre au jour les enjeux stratégiques inhérents à l’impact du "facteur chinois" en RDC. [less ▲]

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See detailPlatelet-rich plasma to treat patellar tendinopathies: a 1 year follow-up.
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in Clinical Chemistry & Laboratory Medicine (2014, June), 52(Special Suppl), 1285

Background: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

Background: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. Infiltration of Platelet Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of the current study is to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies up to 1 year after 1 infiltration of PRP. Methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months and 1 year after the infiltration, using a 10-point Visual Analogic Scale and algofunctional scores (IKDC and VISA-P). Moreover, they had to answer an information questionnaire concerning their life and sports activities. The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. Results: Pain during daily activities significantly decreased with time. VAS has significantly dropped, IKDC and VISA-P significantly improved over the follow-up of 1 year. Seventy percents of patients reported a favourable evolution with decrease of pain, 15% did never report any improvement and 15% were treated surgically. Seventy percents returned to sports activities, 64,3% without any pain, and 50% of them recovered the same sport level. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. Conclusions: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve, at 1 year, symptoms of chronic jumper’s knee in patients non-responsive to classical conservative treatments. [less ▲]

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See detailDoes the achievement of an intermediate glycemic target reduce organ failure and mortality? A post-hoc analysis of the Glucontrol Trial
Penning, Sophie ULg; Chase, J. Geoffrey; Preiser, Jean-Charles et al

in Journal of Critical Care (2014)

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See detailInhibition of PDH Kinase as a new therapeutic target for Age-related Macular Degeneration (AMD)
Arslan, Deniz ULg; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

Poster (2014, June)

Metabolomics is one of the most recent technologies in the world of Omics sciences. It aims at studying metabolome, which is composed of small molecular weight organic molecules (called metabolites) of a ... [more ▼]

Metabolomics is one of the most recent technologies in the world of Omics sciences. It aims at studying metabolome, which is composed of small molecular weight organic molecules (called metabolites) of a cell, an organism or a biological system. This approach gives rise to a growing number of applications in many areas, such as biomarkers discovery, clinical studies, drug efficacy and toxicity evaluation, diagnostic tools, quality control. One of the most interesting features of metabolomics is its capability to extract biochemical information reflecting biological events and then to be a powerful tool in the knowledge of the aetiology of some pathologies. Indeed, it is clear that every disease could alter more or less drastically the metabolic profile of the patients. Then a metabolomics approach could highlight the biochemical pathways affected and could allow the identification of new putative therapeutic strategies or targets that could be useful in a new drug discovery strategy. As proteomics, metabolomics approach represents a new and powerful tool for Medicinal Chemistry. Age-related Macular Degeneration (AMD) is a leading cause of vision loss in the western world among people aged 50 or older. 90% of all vision loss due to AMD results from the exudative form, which is characterized by choroidal neovascularization (CNV). Age-related changes that induce pathologic CNV are incompletely understood. A successful application of anti-VEGF approaches in the clinic is obviously a turning point in AMD treatment. Nevertheless, despite such important advances, critical issues remain to be addressed. To better understand the aetiology of this pathology, we used and improved a murine model of laser-induced choroidal neovascularization and applied a 1H NMR metabolomics study. This approach leads to the emergence of different putative biomarkers and to the validation of the CNV model for an experimental study of AMD. Among these “biomarkers”, lactate appears to be clearly involved in the development of AMD. The modulation of their plasma concentration by treatment of the animals with synthetic compounds and more specifically Pyruvate DesHydrogenase Kinase inhibitors (PDHK) significantly decrease the impact of laser induced CNV. Starting from these results, the development of new PDHK inhibitors could open the way to innovative treatment opportunities in AMD disease. [less ▲]

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See detailSocial Security and Economic Integration
Artige, Lionel ULg; Dedry, Antoine ULg; Pestieau, Pierre ULg

in Economics Letters (2014), 123(June), 318-322

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See detailThe Call for project proposals « Let’s live my village »: between free interpretations and compulsory readings regarding innovation and convivial village ambiance in Wallonia.
Schmitz, Serge ULg

in Les campagnes: espaces d'innovation dans un monde urbain (2014, June)

The paper scrutinizes 186 rural development projects selected on the short list of the first and second “Lets’ live my village!” calls. It examines trends concerning rural community life and the identity ... [more ▼]

The paper scrutinizes 186 rural development projects selected on the short list of the first and second “Lets’ live my village!” calls. It examines trends concerning rural community life and the identity of the leaders/brokers. It pays attention to the way that associations define rurality. Question 14 of the application form « Does your association act in rural areas? Explain” is the main source of information for content analysis and contingency tables [less ▲]

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See detailPhysical controls on the storage of methane in landfast sea ice
Zhou, Jiayun ULg; Tison, J.-L.; Carnat, G. et al

in The Cryosphere (2014), 8(3), 1019-1029

We report on methane (CH4) dynamics in landfast sea ice, brine and under-ice seawater at Barrow in 2009. The CH4 concentrations in under-ice water ranged between 25.9 and 116.4 nmol L-1sw, indicating a ... [more ▼]

We report on methane (CH4) dynamics in landfast sea ice, brine and under-ice seawater at Barrow in 2009. The CH4 concentrations in under-ice water ranged between 25.9 and 116.4 nmol L-1sw, indicating a supersaturation of 700 to 3100 % relative to the atmosphere. In comparison, the CH4 concentrations in sea ice, ranged between 3.4 and 17.2 nmol L-1ice, and the deduced CH4 concentrations in brine, between 13.2 and 677.7 nmol L-1brine. We investigated on the processes explaining the difference in CH4 concentrations between sea ice, brine and the under-ice water, and suggest that biological controls on the storage of CH4 in ice was minor in comparison to the physical controls. Two physical processes regulated the storage of CH4 in our landfast ice samples: bubble formation within the ice and sea ice permeability. Gas bubble formation from solubility changes had favoured the accumulation of CH4 in the ice at the beginning of ice growth. CH4 retention in sea ice was then twice as efficient as that of salt; this also explains the overall higher CH4 concentrations in brine than in the under-ice water. As sea ice thickened, gas bubble formation became less efficient, CH4 was then mainly trapped in the dissolved state. The increase of sea ice permeability during ice melt marked the end of CH4 storage. [less ▲]

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See detailCHARACTERIZATION OF PROTEINURIA IN DOGUE DE BORDEAUX DOGS USING ELECTROPHORESIS AND URINARY BIOMARKERS
Lavoué, Rachel; Smets, P.; Trumel, Cathy et al

in Proceedings of the 2014 ACVIM Forum (2014, June)

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See detailIs Contact Between Conspecifics Involved in the Cohesion of Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae) Aggregations?
Durieux, Delphine ULg; Fassotte, Bérénice ULg; Fischer, Christophe ULg et al

in Journal of Insect Behavior (2014), 27(1), 1-13

The multicolored Asian ladybeetle, Harmonia axyridis (Pallas), exhibits a gregarious behavior during unfavorable winter conditions. Although this behavior is currently described as a phenomenon occurring ... [more ▼]

The multicolored Asian ladybeetle, Harmonia axyridis (Pallas), exhibits a gregarious behavior during unfavorable winter conditions. Although this behavior is currently described as a phenomenon occurring only during winter, aggregations can also be observed outside overwintering conditions. However, the substrate markings previously highlighted as being involved in the wintry aggregation of this exotic species do not seem to be used by non-overwintering individuals to aggregate. This fact suggests then that other cues are responsible for the induction of this behavior. In this work, we have tested the hypothesis that direct contact between non-overwintering individuals stimulates the establishment of clusters. Binary choice experiments highlighted the involvement of elytral cuticular compounds in this phenomenon. Chromatographic analyses showed that the active extracts contained mainly hydrocarbons, including saturated, mono-unsaturated, and di-unsaturated homologues. Physical contact also seems to be involved in the non-overwintering aggregative behavior of H. axyridis, but to a lesser extent than these natural compounds. These findings could eventually be used to develop new control methods of these pest populations and so, reduce the adverse impacts it causes on biodiversity. [less ▲]

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