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See detailImpôts directs et indirects (2015-2016)
Bourgeois, Marc ULg

Learning material (2016)

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See detailLumbopelvic motor control and low back pain in elite soccer players: a cross-sectional study
GROSDENT, Stéphanie ULg; Demoulin, Christophe ULg; Rodriguez de la Cruz, Carlos ULg et al

in Journal of Sports Sciences (2016)

This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1 ... [more ▼]

This study aimed to investigate the relationship between the history of low back pain and quality of lumbopelvic motor control in soccer players. Forty-three male elite soccer players (mean age, 18.2 ± 1.4 years) filled in questionnaires related to low back pain and attended a session to assess lumbopelvic motor control by means of five tests (the bent knee fall out test, the knee lift abdominal test, the sitting knee extension test, the waiter ’ s bow and the transversus abdominis test). A physiotherapist, blinded to the medical history of the participants, scored (0 = failed, 1 = correct) the performance of the players for each of the tests resulting in a lumbopelvic motor control score ranging from 0 to 5. Forty-seven per cent of the soccer players reported a disabling low back pain episode lasting at least two consecutive days in the previous year. These players scored worse lumbopelvic motor control than players without a history of low back pain (lumbopelvic motor control score of 1.8 vs. 3.3, P < 0.01). The between-groups difference was particularly marked for the bent knee fall out test, the knee lift abdominal test and the transversus abdominis test (P < 0.01). In conclusion, most soccer players with a history of low back pain had an altered lumbopelvic motor control. Further research should examine whether lumbopelvic motor control is etiologically involved in low back pain episodes in soccer players. [less ▲]

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See detailPresse: Trouble de la parole Quand le bégaiement chez l’enfant devient inquiétant
Leclercq, Anne-Lise ULg

Diverse speeche and writing (2016)

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See detailEnteral nutrition in preterm neonates
Terrin, Gianluca; SENTERRE, Thibault ULg; Rigo, Jacques et al

in Guandalini, Stefano; Dhawan, Anil; Branski, David (Eds.) Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice (2016)

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See detailImprovement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik ULg; Staumont, Bernard ULg; DUYSINX, Bernard ULg et al

in Current Topics in Medicinal Chemistry (2016), 16

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor ... [more ▼]

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators. [less ▲]

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See detailBrabantophyton, a new genus with stenokolealean affinities from a Middle to earliest Upper Devonian locality from Belgium
Momont, Nicolas ULg; Gerrienne, Philippe ULg; Prestianni, Cyrille

in Review of Palaeobotany and Palynology (2016)

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late ... [more ▼]

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late Middle to earliest Upper Devonian) locality of Ronquières (Belgium). The specimens include stems and lateral organs. The stems are characterized by a protostele dissected into three primary ribs, each of them dividing into two secondary ribs. The protostele shows a central protoxylem strand and numerous strands distributed along the midplanes of the ribs. The vascular supply to lateral organ is composed of two pairs of traces, produced at the same time by the two ribs issued from a single primary rib of the protostele. Within each pair, the shape and the size of the traces are unequal: one is T-shaped and the other is oval to reniform. The T-shaped traces of each pair face each other. The inner cortex of the lateral organs is parenchymatous and the outer cortex is sparganum-like. The specimens of Brabantophyton runcariense show many similarities with the stenokolealean genus Crossia virginiana Beck and Stein, but the vascular supply of lateral organs of the latter consists of a more symmetrical and distinctively simpler pair of traces. Brabantophyton represents the first report of the Stenokoleales in southeastern Laurussia. The characteristics of the Brabantophyton protostele compare better with the anatomy of the radiatopses, and, within the latter, particularly with basal seed plants. [less ▲]

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See detailMolecular detection of six (endo-) symbiotic bacteria in Belgian mosquitoes: first step towards the selection of appropriate paratransgenesis candidates
Raharimalala, Fara Nantenaina; Boukraa, Slimane ULg; Bawin, Thomas ULg et al

in Parasitology Research (2016)

Actually, the use of symbiotic bacteria is one of alternative solution to avoid vector resistance to pesticides. In Belgium, among 31 identified mosquito species, 10 were considered as potential vectors ... [more ▼]

Actually, the use of symbiotic bacteria is one of alternative solution to avoid vector resistance to pesticides. In Belgium, among 31 identified mosquito species, 10 were considered as potential vectors. Given to introduction risks of arbovirosis, the purpose of this study was to investigate the presence of symbiosis bacteria in potential mosquito vectors. Eleven species caught from 12 sites in Belgium were used: Culex pipiens s.l., Culex torrentium, Culex hortensis, Anopheles claviger, Anopheles maculipennis s.l., Anopheles plumbeus, Culiseta annulata, Ochlerotatus geniculatus, Ochlerotatus dorsalis, Aedes albopictus, and Coquillettidia richiardii. Six genera of symbiotic bacteria were screened: Wolbachia sp., Comamonas sp, Delftia sp., Pseudomonas sp., Acinetobacter sp., and Asaia sp.Atotal of 173 mosquito individuals (144 larvae and 29 adults) were used for the polymerase chain reaction screening. Wolbachia was not found in any Anopheles species nor Cx. torrentium. A total absence of Comamonas and Delftia was observed in all species. Acinetobacter, Pseudomonas, and Asaia were found in most of species with a high prevalence for Pseudomonas. These results were discussed to develop potential strategy and exploit the variable occurrence of symbiotic bacteria to focus on them to propose biological ways of mosquito control. [less ▲]

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See detail[18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
WITHOFS, Nadia ULg; Martinive, Philippe ULg; VANDERICK, Jean ULg et al

in European journal of nuclear medicine and molecular imaging (2016)

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]

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See detailPhenolic profile, antibacterial and cytotoxic properties of second grade date extract from Tunisian cultivars (Phoenix dactylifera L.)
Kchaou, Wissal; Abbès, Fatma; Ben Mansour, Riadh et al

in Food Chemistry (2016), (194), 1048-1055

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic ... [more ▼]

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic content was analyzed by HPLC. Antimicrobial activity was evaluated by the agar disk diffusion method, and in vitro cytotoxic activity was examined by cell proliferation assay. The results revealed that second grade dates presented three benzoic acids, five cinnamic acids and two flavonoids, with the predominance of q-coumaric acid (1998.80 lg/100 g). The antimicrobial activities showed that the date extracts were active against Gram (+) and Gram (-) bacteria, showing marked activity against Escherichia coli with an inhibition zone of 25 mm. Cytotoxicity assays showed that the date extracts were able to inhibit the proliferation of HeLa cell lines. The results confirmed that the date extracts were rich in biologically active compounds that are highly valued in the functional food and nutraceutical industries. [less ▲]

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See detailPhysical, functional and structural characterization of the cell wall fractions from baker's yeast Saccharomyces cerevisiae
Borchani, C.; Fonteyn, F.; Jamin, G. et al

in Food Chemistry (2016), 194

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast ... [more ▼]

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast cell wall fractionation process involving enzymatic treatments (savinase and lipolase enzymes) affected most of the physical and functional characteristics of extracted fractions. Thus, the fractionation process showed that β-D-glucan fraction F4 had significantly higher swelling power and fat binding capacity compared to other fractions (F1, F2 and F3). It also exhibited a viscosity of 652.12 mPa s and a high degree of brightness of extracted β-D-glucan fraction. Moreover, the fractionation process seemed to have an effect on structural and thermal properties of extracted fractions. Overall, results showed that yeast β-D-glucan had good potential for use as a prebiotic ingredient in food, as well as medicinal and pharmaceutical products. © 2015, Elsevier Ltd. All rights reserved. [less ▲]

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See detailLe défi climatique, être citoyen co-responsable pour la société de demain? L’expérience du Parlement Citoyen Climat en province de Luxembourg
Stassart, Pierre M ULg

Conference given outside the academic context (2016)

Présentation de l'expérience de parlement climat citoyen en province de Luxembourg qui s'est déroulée de septembre à novembre 2015. La triple innovation sociale autour du tirage au sort, du choix des ... [more ▼]

Présentation de l'expérience de parlement climat citoyen en province de Luxembourg qui s'est déroulée de septembre à novembre 2015. La triple innovation sociale autour du tirage au sort, du choix des experts et de la remise de l'avis au conseil provincial. Bilan provisoire [less ▲]

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See detailGrowth hormone releasing hormone excess and blockade in X-LAG syndrome.
Daly, Adrian Francis ULg; Lysy, Philippe; Defilles, Celine et al

in Endocrine-related cancer (2016)

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and ... [more ▼]

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GH-releasing hormone (GHRH) levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(D-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. [less ▲]

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See detailMonitoring the freshness of fish: development of a qPCR method applied to MAP chilled whiting
Dehaut, Alexandre; Krzewinski, Frédéric; Grard, Thierry et al

in Journal of the Science of Food and Agriculture (2016)

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See detailParenteral nutrition in premature infants
SENTERRE, Thibault ULg; Terrin, Gianluca; De Curtis, Mario et al

in Guandalini, Stephano; Dhawan, Anil; Branski, David (Eds.) Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide to Practice (2016)

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See detailPermeability evolution and water transfer in the excavation damaged zone of a ventilated gallery
Pardoen, Benoît ULg; Talandier, Jean; Collin, Frédéric ULg

in International Journal of Rock Mechanics & Mining Sciences (2016), 85

The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers ... [more ▼]

The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers are mainly conditioned by the behaviour of the surrounding material and by its interaction with the gallery air. The hydro-mechanical behaviour of the excavation damaged zone, which develops around galleries due to the drilling process, is thenceforward critical because it is composed of fractures having a significant irreversible impact on flow characteristics and transfer kinetics. Besides, the material interaction with the gallery air may engender water drainage and desaturation. Thus, a gallery air ventilation experiment, preceded by its excavation, is numerically modelled in an unsaturated argillaceous rock to study its influence on hydraulic transfers. The fractures are numerically represented with shear strain localisation bands by means of a microstructure enriched model including a regularisation method. The impact of fracturing on the transport properties is addressed by associating the intrinsic permeability increase with mechanical deformation which is amplified in the strain localisation discontinuities. Such dependence permits us to reproduce a significant permeability increase of several orders of magnitude in the excavation damaged zone, in agreement with available experimental measurements. After the excavation, the hydraulic transfers are studied through the reproduction of a gallery air ventilation experiment that implies drainage and desaturation of the surrounding rock. These transfers depend on liquid water and water vapour exchanges at gallery wall that are introduced through a non-classical boundary condition. The model prediction successfully captures the drainage and desaturation kinetics of undisturbed and damaged rock. [less ▲]

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See detailHearing “quack” and remembering a duck: Evidence for fluency attribution in young children
Geurten, Marie ULg; Lloyd, Marianne; Willems, Sylvie ULg

in Child Development (2016)

Previous research has suggested that fluency does not influence memory decisions until age 7-8. In two experiments (n=96 and n=64, respectively), children, aged 4, 6, and 8 years (Experiment 1-2), and ... [more ▼]

Previous research has suggested that fluency does not influence memory decisions until age 7-8. In two experiments (n=96 and n=64, respectively), children, aged 4, 6, and 8 years (Experiment 1-2), and adults (Experiment 2) studied a list of pictures. Participants completed a recognition test during which each study item was preceded by a sound providing either a highly predictive or mildly predictive context in order to make some test items more conceptually fluent. Overall, highly predictive items were recognized at a higher rate than mildly predictive items demonstrating an earlier development of the fluency heuristic than previously observed. The study provides insight on how children develop metacognitive expectations and when they start to use them to guide their memory responses. [less ▲]

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See detailImpact of estetrol on breast cancer development, metastatic dissemination and angiogenesis
Gallez, Anne ULg; Gérard, Céline ULg; BLACHER, Silvia ULg et al

Poster (2016)

The increased risk of breast cancer and thromboembolism in women who take Hormone Replacement Therapy (HRT) currently is a major public health problem. The discovery of novel molecules with better safety ... [more ▼]

The increased risk of breast cancer and thromboembolism in women who take Hormone Replacement Therapy (HRT) currently is a major public health problem. The discovery of novel molecules with better safety profile would provide useful advances for patient care. Estretrol (E4) appears as a promising candidate for HRT. Indeed, in contrast to current treatment containing ethinyl estradiol or estradiol (E2), E4 has a minimal impact on liver cells activity supporting a decreased incidence on thromboembolic events. In preclinical studies, E4 has been effective against the main symptoms of menopause such as hot flushes, vaginal atrophy, and osteoporosis, from a starting dose of 0.3 mg/kg/day. The aim of this study was to define the impact of E4 on breast cancer development when it is used at concentrations effective for menopause symptom relief. Treatment of estrogen receptor (ER)-positive breast cancer-developing mice (MMTV-PyMT) with several concentrations of E4 has shown that 0.3 mg/kg/day E4 did not increase tumor development and metastasis dissemination. However, at 3mg/kg/day, E4 increased the growth of hormone-dependent tumors and their metastatic dissemination in ovariectomized and intact mice. This effect was similar to the one observed with E2 used at 0.08 mg/kg/day. In an in vivo model of ER-negative tumors, we observed that 3mg/kg/day E4 improved tumor growth by increasing angiogenesis, and subsequently decreasing necrosis and tumor hypoxia. In contrast, 0.3 mg/kg/day E4 did not induce any of these effects on ER-negative tumors and tumor microenvironment. In conclusion, we have shown that 0.3 mg/kg/day E4, already reported to prevent menopause symptoms, does not increase breast tumor growth, metastasis dissemination, and angiogenesis. However, similarly to E2, higher concentrations of E4 are pro-tumorous. These results support that E4, if it is used in strictly controlled clinical applications, could have no or only limited impact on breast cancer. [less ▲]

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See detailSparse plus low-rank autoregressive identification in neuroimaging time series
Liegeois, Raphaël ULg; Mishra, Bamdev ULg; Zorzi, Mattia et al

in Proceedings of CDC 2015 (2016)

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See detailPost-discharge formula for premature infants, is it needed?
SENTERRE, Thibault ULg

Conference (2016)

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