Last 7 days
Bookmark and Share    
See detailMars atmospheric escape constrained using MAVEN IUVS coronal observations
Chaffin; Deighan; Chauffray et al

Conference (2015, October)

Detailed reference viewed: 12 (0 ULg)
See detailNews about Nitric Oxide
Stiepen, Arnaud ULg

Scientific conference (2015, October)

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailEyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
Vanvinckenroye, Amaury ULg; Vandewalle, Gilles ULg; Phillips, Christophe ULg et al

in Neural Plasticity (2015)

Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by ... [more ▼]

Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space. On a much longer time scale, brain function also depends on prior sleep-wake history and circadian processes. However,much remains to be established on how the brain operates at the neuronal level in humans during sleep and wakefulness. A key limitation of human neuroscience is the difficulty in isolating neuronal excitation/inhibition drive in vivo. Therefore, computational models are noninvasive approaches of choice to indirectly access hidden neuronal states. In this review, we present a physiologically driven in silico approach, Dynamic Causal Modelling (DCM), as a means to comprehend brain function under different experimental paradigms. Importantly, DCM has allowed for the understanding of how brain dynamics underscore brain plasticity, cognition, and different states of consciousness. In a broader perspective, noninvasive computational approaches, such as DCM, may help to puzzle out the spatial and temporal dynamics of human brain function at different behavioural states. [less ▲]

Detailed reference viewed: 39 (7 ULg)
Full Text
See detailLa laïcité réactionnaire : une tentative de déconstruction
Jacquemain, Marc ULg

in Durand, Pascal; Sindaco, Sarah (Eds.) Le discours néréactionnaire (2015)

Le mot "laïcité" est revendiqué par des groupes d'extrême-droite ouvertement racistes et conspirationnistes comme "Riposte laïque". L'article montre que le même imaginaire conspirationniste, sous la même ... [more ▼]

Le mot "laïcité" est revendiqué par des groupes d'extrême-droite ouvertement racistes et conspirationnistes comme "Riposte laïque". L'article montre que le même imaginaire conspirationniste, sous la même structure narrative peut être retrouvé sous des formes débarrassée de leur racisme explicite dans des textes considérés comme "mainstream" au sein de la laïcité, en analysant un texte du Rappel. A partir de là, on tente de montrer que cette "dérivation conspirationniste" peut trouver des prises dans des formulations "progressistes" de la laîcité dès lors que ces formulations partent pour point de départ le point de vue à la fois holiste et idéaliste d'un "laos" toujours-dejà-là, comme chez Peña ruiz [less ▲]

Detailed reference viewed: 263 (12 ULg)
Full Text
Peer Reviewed
See detailHighlights of the 13th International Conference on Malignant Lymphoma
BONNET, Christophe ULg; BOSLY, A.

in Belgian Journal of Hematology (2015), 6(4), 173-178

A lot of interesting data were presented at the 13th International Conference on Malignant Lymphoma in Lugano, Switzerland. The authors summarise below those presentations/abstracts they found relevant ... [more ▼]

A lot of interesting data were presented at the 13th International Conference on Malignant Lymphoma in Lugano, Switzerland. The authors summarise below those presentations/abstracts they found relevant for daily practice, either now or in the near future. [less ▲]

Detailed reference viewed: 29 (0 ULg)
Full Text
Peer Reviewed
See detailWaldenström's macroglobulinaemia: Belgian Hematology Society guidelines
VAN HENDE, V.; BRON, D.; VAN DEN NESTE, E. et al

in Belgian Journal of Hematology (2015), 6(4), 142-151

Waldenström’s macroglobulinaemia is a B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy in the blood. This ... [more ▼]

Waldenström’s macroglobulinaemia is a B-cell disorder characterised by bone marrow infiltration with lymphoplasmacytic cells, along with demonstration of an IgM monoclonal gammopathy in the blood. This condition belongs to the lymphoplasmacytic lymphomas as defined by the World Health Organization classification (ICD-0 code 9671/3). Approximately one-fourth of patients are asymptomatic. Clinical features of the symptomatic patients are diverse and may relate to overall disease burden (such as peripheral blood cytopaenias, organomegaly and constitutional symptoms) or may be directly attributable to the IgM paraprotein. The latter include hyperviscosity syndrome, amyloidosis, peripheral neuropathy and cold haemagglutinin. Therapeutic options have traditionally involved alkylating agents, nucleoside analogues, and rituximab, either as single therapy or in combination. However, emerging new data on combination therapy as well as novel agents have shown encouraging results. This report provides the Belgian Hematology Society guidelines according to recent clinical studies. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailÉcologie et gestion des espèces multi-usages du genre Erythrophleum (Fabaceae-Caesalpinioideae) en Afrique (synthèse bibliographique)
Gorel, Anaïs ULg; Fayolle, Adeline; Doucet, Jean-Louis ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19

Littérature. Erythrophleum ivorense, E. suaveolens, E. africanum et E. lasianthum diffèrent morphologiquement et sont présentes dans des aires climatiques distinctes. Elles sont héliophiles non pionnières ... [more ▼]

Littérature. Erythrophleum ivorense, E. suaveolens, E. africanum et E. lasianthum diffèrent morphologiquement et sont présentes dans des aires climatiques distinctes. Elles sont héliophiles non pionnières (E. ivorense et E. suaveolens) ou pionnières (E. africanum). La dispersion primaire est ballochore. Les graines présentent une période de dormance et peuvent rester plusieurs années dans le sol. La phénologie est régulière et annuelle. La croissance annuelle moyenne varie entre les espèces, de la plus élevée pour E. ivorense (0,65 cm par an) à la plus faible pour E. africanum (0,16 cm par an). Elles sont largement utilisées dans la médecine traditionnelle. Seules E. ivorense et E. suaveolens sont exploitées pour le bois d’oeuvre et soumises à des normes d’exploitation et des tests sylvicoles. Conclusions. Les données sur l’écologie des espèces du genre Erythrophleum sont globalement mieux renseignées pour E. ivorense et E. suaveolens en raison de leur importance économique. Cette synthèse a permis de mettre en évidence certains manques de connaissances notamment sur la phénologie (relation avec le climat, périodes de fructifications), les diamètres minimums de fructification et les mécanismes de levée de dormance naturelle des graines. Remédier à ces lacunes contribuerait notablement à améliorer les méthodes de gestion des populations de ces espèces. [less ▲]

Detailed reference viewed: 44 (6 ULg)
Full Text
Peer Reviewed
See detailLymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype.
Fernandes, Monica T.; Ghezzo, Marinella N.; Silveira, Andre B. et al

in British journal of haematology (2015)

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we ... [more ▼]

Lymphotoxin-mediated activation of the lymphotoxin-beta receptor (LTbetaR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-alpha and LTbeta (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (Lta, Ltb). In these mice, expression of Lta and Ltb is elevated in early stage T-ALL. Surface LTalpha1 beta2 protein is expressed in primary mouse T-ALL cells, but only in the absence of microenvironmental LTbetaR interaction. Indeed, surface LT expression is suppressed in leukaemic cells contacting Ltbr-expressing but not Ltbr-deficient stromal cells, both in vitro and in vivo, thus indicating that dynamic surface LT expression in leukaemic cells depends on interaction with its receptor. Supporting the notion that LT signalling plays a role in T-ALL, inactivation of Ltbr results in a significant delay in TEL-JAK2-induced leukaemia onset. Moreover, young asymptomatic TEL-JAK2;Ltbr-/- mice present markedly less leukaemic thymocytes than age-matched TEL-JAK2;Ltbr+/+ mice and interference with LTbetaR function at this early stage delayed T-ALL development. We conclude that LT expression by T-ALL cells activates LTbetaR signalling in thymic stromal cells, thus promoting leukaemogenesis. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
See detailStrategic Organization Design: from the strategy to the task
Haine, Sabine ULg; Robert, Jocelyne ULg

Learning material (2015)

Detailed reference viewed: 285 (65 ULg)
Full Text
See detailSILURIAN – DEVONIAN OF THE ORIENTAL ALGERIAN SAHARA: implication of new field data from Tassili n'Ajjer outcrops and Berkine Basin (SE, Algeria) for shale gas exploration.
Djouder, Hocine ULg; Boulvain, Frédéric ULg; Da Silva, Anne-Christine ULg et al

in EPC'2015 THE THIRTEENTH TUNISIAN PETROLEUM EXPLORATION & PRODUCTION CONFERENCE (2015, October)

The Silurian – Devonian succession have been deposited in wide sags and sub-basins in a cratonic setting, along the northwestern passive margin of the Gondwana during the opening of the proto-Tethyan ... [more ▼]

The Silurian – Devonian succession have been deposited in wide sags and sub-basins in a cratonic setting, along the northwestern passive margin of the Gondwana during the opening of the proto-Tethyan ocean. During this Siluro-Devonian Period, a high subsidence occurs stacked sediment bodies and organic-rich shales were deposited in many places that respectively form important hydrocarbon reservoirs and source rocks throughout North Africa basins and Arabia (Boot et al., 1998 ; Lüning et al., 2000), which lead Algeria to hold the fourth position in terms of the estimates of technically recoverable shale oil and shale gas resources, based on major basin assessment in the world (EIA, 2013). In the prolific Illizi and Berkine basins (western Ghadames, Algeria) a basin-wide approach is needed, especially with the new “shale gas and shale oil” frontier in the upcoming years, in order to capture regional trends and re-assessment on organic-rich (‘hot’) shale unites which in smaller-scale industrial studies are overlooked. Berkine Basin covers nearly 102.000 km2. This basin has been a thick sedimentary series of 7000 m corresponding to complex reservoirs but also black shales of the basal Silurian and Frasnian respectively major and secondary source rock systems. Wireline-logs from more than 146 (Berkine – Illizi Basins) Algerian petroleum exploration wells have been studies (Djouder et al., 2012; Djouder et al., 2014), and recently 03 months extensive field study of outcrops of the Siluro-Devonian sediments was carried out at the south margin (SE, Tassili n’Ajjer) of the basin. The following analysis incorporates biostratigraphic, ichnological, sedimentological and high resolution stratigraphic data, which provides a framework evolution from offshore to deltaic deposition for the Silurian then fluvial to normal-marine depositional conditions for the Devonian. A total of 06 short-term, third-order sequences can be identified for the Silurian deposits: (i) 'Hot Shale' Oued Imihrou Formation, organic-rich shales with carbonates nodules (Si-1); (ii) above is the Atafaïtafa Formation 500 to 650 m thick with HCS, gutter casts and Cruziana Ichnofacies (Si-2, Si-3); (iii) then overlaid by coarsening-shallowing-upward units. These sequences (Si-4, Si-5 & Si-6) with Storm-wave dominated and Skolithos Ichnofacies are interpreted to reflect deltaic origin. This delta is the result of a significant sea-level drop during the Upper Silurian (Beuf et al, 1971) but also from the high sedimentation rates prograding northwards (Eschard et al., 2005). Devonian deposit also can be divided into fourth third-order sequences (Dev-1 to 4), by the same previous analysis. The base of the cycle is the Caledonian unconformity linked to a tectonic event which affected most of the Gondwanan margin at the Silurian – Devonian boundary and a major relative sea-level fall (Eschard et al., 2005). Previous sequences defined from Tassili n’Ajjer outcrops are well recognized at the basin-scale (Berkine Basin) and can be correlated in the subsurface of the Illizi – Berkine basins (Djouder et al., 2012). Finally, the full depositional cycle for the Silurian – Devonian is reached and capped by the Frasnian maximum flooding surface, with black shales across North Africa (Algeria, western Libya and southern Tunisia) and which are also developed in many parts of the world (Lüning et al., 2003). [less ▲]

Detailed reference viewed: 51 (12 ULg)
Full Text
Peer Reviewed
See detailSURFACE ENGINEERING FOR PARTS MADE BY ADDITIVE MANUFACTURING
Nutal, Nicolas; Rochus, Pierre ULg; Collette, Jean-Paul et al

in 66th International Astronautical Congress (2015, October)

the surface preparation of metal parts made by additive manufacturing (AM). AM is a technology of choice for manufacturing of parts with complex shapes (heat exchangers, RF supports, optical parts…) and ... [more ▼]

the surface preparation of metal parts made by additive manufacturing (AM). AM is a technology of choice for manufacturing of parts with complex shapes (heat exchangers, RF supports, optical parts…) and integrated functions such as conformal cooling channels, clips, hinges, etc. This opens the door for lightweight parts which are of prime importance for space applications. The potential of the AM technologies is however impeded by the quite rough surface finish that is observed on the as-manufactured parts. It is known that such a finish is likely to impact the performance of the parts. Several post-treatment techniques can be applied to improve the surface condition of the AM parts. However, so far, the influence of the successive post-processing steps on the final properties is not well established. Therefore, a better understanding of the impact of surface characteristics on the material behaviour is needed to expand the use of AM for high performance parts. The objective of this study, supported by ESA, is to propose and evaluate various surface finishing techniques for parts made by the AM technologies, in order to check their compatibility, evaluate their properties and derive guidelines for future applications. CRM is the prime proposer of this study and is in charge of the surface treatment and characterisations. Sirris additive manufacturing facilities are used to produce the parts. Thales Alenia Space and Walopt are included into the industrial team to provide concrete application cases. The study focuses on metals. Two metals under study are presented here: AlSi10Mg and Ti6Al4V. This paper is devoted to the early results of the first steps of surface preparation, namely material removal from the surface of the produced parts in order to improve their surface properties. As a first phase, tribo-finishing (TF) is tested on prototype parts to check its capabilities. Surface and volume parameters are analyzed, namely achieved roughness, material removal rate, location of removed material. The limitations in terms of geometry and applicability are discussed as well. These first observations should serve as guidelines for further application of AM for the design of parts used in space industry. [less ▲]

Detailed reference viewed: 47 (5 ULg)
Full Text
Peer Reviewed
See detailSofosbuvir in combination with simeprevir +/- ribavirin in genotype 4 hepatitis C patients with advanced fibrosis or cirrhosis: a real-life experience from Belgium
Moreno, C; Lasser, L; DELWAIDE, Jean ULg et al

in Hepatology (Baltimore, Md.) (2015, October), 62(1), 746

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However ... [more ▼]

Background: All-oral, interferon-free regimens that combine direct-acting antiviral drugs have significantly advanced the treatment of hepatitis C (HCV), especially for genotype 1(G1) patients. However, efficacy and safety data of interferon-free regimens in HCV genotype 4 (G4) patients are scarce. In Belgium, Sofosbuvir (SOF) and Simeprevir (SMV) treatment is available since January 2015 for G4 patients with advanced fibrosis (F3-F4 METAVIR) for 12 weeks. Methods: analysis of HCV G4 patients receiving SOF and SMV treatment in Belgium. The aim of the study was to evaluate the safety and efficacy of the treatment. Results: 73 G4 patients were enrolled in this data collection including 32 (43.8%) patients with severe fibrosis F3 and 41(56.2%) cirrhotic patients. The study population comprised 58.9% male, 77.8% treatment experienced patients. Median age was 59 [51-66] years and 5 patients were HCV/HIV co-infected. 24 patients received the treatment associated with ribavirin, 11/32 (34.37%) of patients with advanced fibrosis and 13/41 (31.71%) of cirrhotic patients. In cirrhotic patients, median MELD and Child-Pugh score were 9 [7-12.5] and 5 [5-6], 46.2% had platelet below 100.000/mm and 28.6% had albumin below 35 g/L. W4 HCV RNA was undetectable in 31.25% (15/48). 9 of the 15 patients with undetectable W4 HCV RNA received RBV. At W12, 100% (23/23) had HCV RNA below the limit of quantification, with 6/23 still detectable. All SVR12 data will be available at the time of presentation. No patient experienced serious adverse event. Conclusions: these preliminary results in difficult-to-treat G4 HCV patients show that SOF/SIM +/- RBV treatment is safe and seems promising, in line with that was observed in G1 HCV patients. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Full Text
See detailApparatuses as loci of bio-political emergence: development of genetic testing in Belgium
Fallon, Catherine ULg

Conference (2015, October)

In his vision of “biopolitics” Lemke (2011) proposes to conceptualize life and politics as entities intertwined within a dynamic relationship. These technologies change the production of norms and the ... [more ▼]

In his vision of “biopolitics” Lemke (2011) proposes to conceptualize life and politics as entities intertwined within a dynamic relationship. These technologies change the production of norms and the apparatuses (Foucault 2008) organizing the distribution of the living in the domain of utility: therefore biopolitics must be analyzed as center pieces in the transformation of politics. The developments in genomics and epigenetics support the vision of the individual body as an “information network” rather than a physical substrate. The experts (with the active support of the patients) construct models for the calculation of life in the development of policy regulation and contribute actively to frame the policy relevant issues – either at individual or at population level, on the basis of power strategies mobilizing and disseminating specific forms of knowledge which are disciplined and selective. The contribution will present the recent evolution of the apparatuses producing the technical regulation and financial norms for the use of genetic testing in the federal Belgian public health system, considering the two complementary level of the “dispositif” : - At the political level, transformation of the « Conseil supérieur de la Génétique humaine » (1973-2013) into a « Collège de médecins pour le centre de génétique humaine » and the development of new control relations between the subsidizing and control bodies and the hospitals, - At the individual level, transformation of the cooperation between medical doctors, biomedical experts and psycho-sociologists in the relationship with the patients, as they can be observed at the level of the hospital; Who has the resources (intellectual, technological or financial) to control the technology and its use ? what are the social, institutional and technological constrains? who defines and select the legitimate options ? The analysis is not so much normative than critical, giving due attention to the social context and contingent rationalities in the evolution of this peculiar political action, with the aim of opening new areas of discussions transgressing disciplinary and institutional borders which are too often considered as self evident. [less ▲]

Detailed reference viewed: 36 (0 ULg)
Full Text
Peer Reviewed
See detailAnalyse exploratoire des liens entre l’interaction entraîneur-joueuses, les représentaitons mutuelles de l’entraînement et la performance sportive
Rémy, Elodie; Manfredini, Tiber ULg; Cloes, Marc ULg

in Bulletin de Psychologie (2015), 68(5), 355-366

The coach-athlete relationship is well documented in the literature. Based on an original research model, the study is focused on three female basketball clubs of the 1st regional division in Wallonia ... [more ▼]

The coach-athlete relationship is well documented in the literature. Based on an original research model, the study is focused on three female basketball clubs of the 1st regional division in Wallonia. Combining interviews, participant observation, focus groups, and perception questionnaires, it appears that the relational dynamics of the three sites differs considerably: ‘Back to back’, ‘Above-below’, ‘Inside’. In each case, the coach-players relationship does not seem suitable to the optimal use of the available resources, in order to reach a sport performance in agreement. Courses of actions are suggested for provoking some improvement of the situations. [less ▲]

Detailed reference viewed: 33 (0 ULg)
See detailJochen Gerner (monographie)
Crucifix, Benoît ULg

Article for general public (2015)

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailStudy of the interaction between the MtgA and inhibitory compounds
Dahmane, Ismahene ULg

Poster (2015, October)

Detailed reference viewed: 17 (2 ULg)
See detailBioresources and circular economy - Strategic approach for Wallonia
Richel, Aurore ULg

Speech/Talk (2015)

Detailed reference viewed: 26 (8 ULg)
Peer Reviewed
See detailTriclosan retardes development of Sheepshead minnow (Cyprinodon variegatus)
Dussenne, Mélanie ULg; Frederich, Bruno ULg; Das, Krishna ULg et al

Conference (2015, October)

The aquatic environment represents the final sink for many chemicals, including bactericidal agents. Among them Triclosan (TCS), with his chemical structure similar to thyroid hormones (THs), may have ... [more ▼]

The aquatic environment represents the final sink for many chemicals, including bactericidal agents. Among them Triclosan (TCS), with his chemical structure similar to thyroid hormones (THs), may have adverse effects on the thyroid system. The study we carried out aims to evaluate the effects of TCS exposure on development of Cyprinodon variegatus, a fish model used in ecotoxicological studies. We investigated the potential effects of TCS on C. variegatus during two key periods; embryonic development and metamorphosis. We exposed eggs and larvae to environmental relevant concentrations. We showed that TCS had no effect on reproduction parameters, such as egg fertility or survival rate of larvae. However, we highlighted the fact that hatching of exposed larvae was delayed of around 6 to 13 hours compared to control embryos. During the larval phase, measurements of THs levels were performed. We showed that TCS affected the typical ontogenic variations of the whole body thyroid hormones concentrations during metamorphosis. As THs are known to control somatic growth and development, we tested the effects of TCS exposure on morphological development. We observed no deformity or malformation, but we revealed a developmental retardation in larvae exposed to TCS, of around 18 to 32 hours. Such a developmental delay had never been highlighted in previous studies on TCS exposed fish. We hypothesize that the disruption of THs homeostasis affects the timing of the start of metamorphosis. As a consequence, exposed larvae showed an extended larval phase compared to the control group. The harmful effects of TCS on physiology and development are a major concern, as marine organisms are constantly exposed to it. Furthermore, strong connections exist between thyroid and reproductive system, which might have deleterious effects on population dynamics. [less ▲]

Detailed reference viewed: 39 (8 ULg)