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See detailRelations on words
Rigo, Michel ULg

in Indagationes Mathematicae (2017), 28

In the first part of this survey, we present classical notions arising in combinatorics on words: growth function of a language, complexity function of an infinite word, pattern avoidance, periodicity and ... [more ▼]

In the first part of this survey, we present classical notions arising in combinatorics on words: growth function of a language, complexity function of an infinite word, pattern avoidance, periodicity and uniform recurrence. Our presentation tries to set up a unified framework with respect to a given binary relation. In the second part, we mainly focus on abelian equivalence, $k$-abelian equivalence, combinatorial coefficients and associated relations, Parikh matrices and $M$-equivalence. In particular, some new refinements of abelian equivalence are introduced. [less ▲]

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See detailNanomedicine as a potent strategy in melanoma tumor microenvironment
Pautu, Vincent ULg; Leonetti, Daniela; Lepeltier, Elise et al

in Pharmacological Research (2017)

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See detailInfusion of mesenchymal stromal cells after deceased liver transplantation: A phase I-II, open-label, clinical study.
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Journal of Hepatology (2017)

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the ... [more ▼]

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the feasibility, safety and tolerability of a single infusion of MSCs in liver transplant recipients. METHODS: Ten liver transplant recipients under standard immunosuppression received 1.5-3x106/kg third-party unrelated MSCs on post-operative day 3+/-2, and were prospectively compared to a control group of 10 liver transplant recipients. As primary end-points, MSC infusional toxicity was evaluated, and infectious and cancerous complications were prospectively recorded until month 12 in both groups. As secondary end-points, rejection rate, month-6 graft biopsies, and peripheral blood lymphocyte phenotyping were compared. Progressive immunosuppression weaning was attempted from month 6 to 12 in MSC recipients. RESULTS: No variation in vital parameters or cytokine release syndrome could be detected during and after MSC infusion. No patient developed impairment of organ functions (including liver graft function) following MSC infusion. No increased rate of opportunistic infection or de novo cancer was detected. As secondary end-points, there was no difference in overall rates of rejection or graft survival. Month-6 biopsies did not demonstrate a difference between groups in the evaluation of rejection according to the Banff criteria, in the fibrosis score or in immunohistochemistry (including Tregs). No difference in peripheral blood lymphocyte typing could be detected. The immunosuppression weaning in MSC recipients was not successful. CONCLUSIONS: No side effect of MSC infusion at day 3 after liver transplant could be detected, but this infusion did not promote tolerance. This study opens the way for further MSC or Treg-based trials in liver transplant recipients. LAY SUMMARY: Therapy with mesenchymal stromal cells (MSCs) has been proposed as a mean to improve results of solid organ transplantation. One of the potential MSC role could be to induce tolerance after liver transplantation, i.e. allowing the cessation of several medications with severe side effects. This study is the first-in-man use of MSC therapy in 10 liver transplant recipients. This study did not show toxicity after a single MSC infusion but it was not sufficient to allow withdrawal of immunosuppression. [less ▲]

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See detailSoil organic carbon fractionation for improving agricultural soil quality assessment – a case study in Southern Belgium (Wallonia)
Trigalet, Sylvain; Chartin, Caroline; Krüger, Inken ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21(S1),

Description of the subject. The paper presents and discusses a method for fractionating bulk soil organic carbon (SOC) in meaningful SOC fractions to better assess SOC status and its related soil ... [more ▼]

Description of the subject. The paper presents and discusses a method for fractionating bulk soil organic carbon (SOC) in meaningful SOC fractions to better assess SOC status and its related soil ecosystem functions. Objectives. The objective is to perform an evaluation of ecosystem functions of soil organic matter at plot scale and compare it to the normal operative range of the local agro-ecological region. Method. By separating carbon associated with clay and fine silt particles (stable carbon with slow turnover rate, < 20 μm) and carbon non-associated with this fraction (labile and intermediate carbon with higher turnover rates, ≥ 20 μm), effects of management can be detected more efficiently at different scales. Conclusions. Soil organic carbon fractions, used as proxies for soil ecosystem functions, can be helpful because they represent SOC functional pools. This paper proposes to apply fractionation on samples taken at plot and regional scale. It is therefore possible to establish a normal operative range for a specific agro-region for comparison with the values in individual plots. This allows drawing a baseline for SOC fractions status in a specific agricultural unit. This approach provides valuable information to study and evaluate the impact of agricultural management in the context of enhancing soil quality and functions. [less ▲]

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See detailIntegrating biological indicators in a Soil Monitoring Network (SMN) to improve soil quality diagnosis – a study case in Southern Belgium (Wallonia)
Krüger, Inken ULg; Chartin, Caroline; van Wesemael, Bas et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 31(S1),

Soil organisms and their activities are essential for soil ecosystem functioning and they can thus be used as pertinent indicators of soil quality. Recent efforts have been undertaken to include ... [more ▼]

Soil organisms and their activities are essential for soil ecosystem functioning and they can thus be used as pertinent indicators of soil quality. Recent efforts have been undertaken to include biological indicators of soil quality into regional/national monitoring networks. Objectives. The aim of this study was to provide a first dataset of six biological indicators and two eco-physiological quotients for two landscape units in Wallonia. These spatial units are characterized by homogeneous climate conditions, soil type, land-use and management (here, grasslands in the Ardennes, and croplands in the Loam Region). Method. Respiration potential, microbial biomass carbon and nitrogen, net nitrogen mineralization, metabolic potential of soil bacteria and earthworm abundance were measured at a total of 60 sites in two different landscape units (LSU). Variability within each LSU was studied. Data was synthesized through calculation of a comprehensive score and presentation as radar plots. Results. All selected biological indicators were significantly higher under grassland than under cropland soils, highlighting the biological indicators’ power of discrimination between main land use types. Variability within LSU depended on the biological indicator and was generally higher in grassland than in cropland soils. Each site could unambiguously be assigned to its landscape unit based on its calculated comprehensive score. Radar plots allowed an assessment of the distribution of values within a landscape unit at a glance. Conclusions. The pilot-study defined the first baseline values for agricultural soils in Wallonia and laid the foundation for a monitoring network of biological soil quality. [less ▲]

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See detailComment j'utilise le blended learning et la classe inversée
Pochet, Bernard ULg

Speech/Talk (2017)

Make a little history Present the reasons for my choice Presenting the current framework Present the principles of the flipped classroom Show how I use the blended learning and flipped classroom Some ... [more ▼]

Make a little history Present the reasons for my choice Presenting the current framework Present the principles of the flipped classroom Show how I use the blended learning and flipped classroom Some questions ... [less ▲]

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See detailDisease Note. First Report of Persimmon Cryptic Virus in Spain
Ruiz-Garcia, A-B; Chamberland, N.; Martinez, C. et al

in Journal of Plant Pathology [=JPP] (2017), 99(1),

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See detailEekenhof
Leyh, Valérie ULg

in Philipp Theisohn; Christian Demandt (Eds.) Theodor Storm-Handbuch. Leben - Werk - Wirkung (2017)

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See detailIm Brauer-Hause
Leyh, Valérie ULg

in Philipp Theisohn; Christian Demandt (Eds.) Theodor Storm-Handbuch. Leben - Werk - Wirkung (2017)

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See detailThe Politics and Aesthetics of Hunger and Disgust: Perspectives on the Dark Grotesque
Delville, Michel ULg; Norris, Andrew

Book published by Routledge (2017)

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See detailWaldwinkel
Leyh, Valérie ULg

in Christian Demandt; Philipp Theisohn (Eds.) Theodor Storm-Handbuch. Leben - Werk - Wirkung (2017)

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See detailTowards a chromatographic similarity index to establish localized quantitative structure-retention models for retention prediction: Use of retention factor ratio
Tyteca, Eva ULg; Talebi, M.; Amos, R. et al

in Journal of Chromatography. A (2017), 1486

Quantitative Structure-Retention Relationships (QSRR) have the potential to speed up the screening phase of chromatographic method development as the initial exploratory experiments are replaced by ... [more ▼]

Quantitative Structure-Retention Relationships (QSRR) have the potential to speed up the screening phase of chromatographic method development as the initial exploratory experiments are replaced by prediction of analyte retention based solely on the structure of the molecule. The present study offers further proof-of-concept of localized QSRR modelling, in which the retention of any given compound is predicted using only the most chromatographically similar compounds in the available dataset. To this end, each compound in the dataset was sequentially removed from the database and individually utilized as a test analyte. In this study, we propose the retention factor k as the most relevant chromatographic similarity measure and compare it with the Tanimoto index, the most popular similarity measure based on chemical structure. Prediction error was reduced by up to 8 fold when QSRR was based only on chromatographically similar compounds rather than using the entire dataset. The study therefore shows that the design of a practically useful structural similarity index should select the same compounds in the dataset as does the k-similarity filter in order to establish accurate predictive localized QSRR models. While low average prediction errors (Mean Absolute Error (MAE) < 0.5 min) and slopes of the regression lines through the origin close to 1.00 were obtained using k-similarity searching, the use of the structural Tanimoto similarity index, considered as the gold standard in Quantitative Structure-Activity Relationships (QSAR) studies, generally resulted in much higher prediction errors (MAE > 1 min) and significant deviations from the reference slope of 1.0. The Tanomoto similarity index therefore appears to have limited general utility in QSRR studies. Future studies therefore aim at designing a more appropriate chromatographic similarity index that can then be applied for unknown compounds (that is, compounds which have not been tested previously on the chromatographic system used, but for which the chemical structures are known). © 2016 [less ▲]

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See detailElements of stochastic processes 2016--2017: course material
Arnst, Maarten ULg

Learning material (2017)

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See detailProtean proteases: at the cutting edge of lung diseases.
Taggart, Clifford; Mall, Marcus A.; Lalmanach, Gilles et al

in European Respiratory Journal (2017), 49(2),

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and ... [more ▼]

Proteases were traditionally viewed as mere protein-degrading enzymes with a very restricted spectrum of substrates. A major expansion in protease research has uncovered a variety of novel substrates, and it is now evident that proteases are critical pleiotropic actors orchestrating pathophysiological processes. Recent findings evidenced that the net proteolytic activity also relies upon interconnections between different protease and protease inhibitor families in the protease web.In this review, we provide an overview of these novel concepts with a particular focus on pulmonary pathophysiology. We describe the emerging roles of several protease families including cysteine and serine proteases.The complexity of the protease web is exemplified in the light of multidimensional regulation of serine protease activity by matrix metalloproteases through cognate serine protease inhibitor processing. Finally, we will highlight how deregulated protease activity during pulmonary pathogenesis may be exploited for diagnosis/prognosis purposes, and utilised as a therapeutic tool using nanotechnologies.Considering proteases as part of an integrative biology perspective may pave the way for the development of new therapeutic targets to treat pulmonary diseases related to intrinsic protease deregulation. [less ▲]

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See detailPreterm Infant Growth Velocity Calculations: A Systematic Review
Fenton, Tanis; Chan, Hilton; Madhu, Aiswarya et al

in Pediatrics (2017), 139(3), 1-10

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See detailKey impact of an uncommon plasmid on bacillus amyloliquefaciens subsp. plantarum S499 developmental traits and lipopeptide production
Molinatto, G.; Franzil, L.; Steels, Sébastien ULg et al

in Frontiers in Microbiology (2017), 8(JAN),

The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant ... [more ▼]

The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant disease protection provided by this strain. Sequencing of the S499 genome has highlighted genetic differences and similarities with the closely related rhizobacterium B. amyloliquefaciens subsp. plantarum FZB42 (FZB42). More specifically, a rare 8008 bp plasmid (pS499) harboring a rap-phr cassette constitutes a major distinctive element between S499 and FZB42. By curing this plasmid, we demonstrated that its presence is crucial for preserving the typical physiology of S499 cells. Indeed, the growth rate and extracellular proteolytic activity were significantly affected in the cured strain (S499 P-). Furthermore, pS499 made a significant contribution to the regulation of cyclic lipopeptide production. Surfactins and fengycins were produced in higher quantities by S499 P-, whereas lower amounts of iturins were detected. In line with the increase in surfactin release, bacterial motility improved after curing, whereas the ability to form biofilm was reduced in vitro. The antagonistic effect against phytopathogenic fungi was also limited for S499 P-, most probably due to the reduction of iturin production. With the exception of this last aspect, S499 P- behavior fell between that of S499 and FZB42, suggesting a role for the plasmid in shaping some of the phenotypic differences observed in the two strains. © 2017 Molinatto, Franzil, Steels, Puopolo, Pertot and Ongena. [less ▲]

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See detailA Belgian survey on the diagnosis of asthma-COPD overlap syndrome.
Cataldo, Didier ULg; Corhay, Jean-Louis ULg; Derom, Eric et al

in International Journal of Chronic Obstructive Pulmonary Disease (2017), 12

INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse ... [more ▼]

INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse and inconsistent. This survey aimed to identify consensus on criteria for diagnosing ACOS. METHODS: A Belgian expert panel developed a survey on ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen by >/=70% of survey respondents were considered as useful criteria for ACOS diagnosis. The two most frequently selected answers were considered as major criteria, others as minor criteria. The expert panel proposed a minimal requirement of two major criteria and one minor criterion for ACOS diagnosis. Respondents were also asked which criteria are important for considering inhaled corticosteroids prescription in a COPD patient. RESULTS: To diagnose ACOS in COPD patients, major criteria were "high degree of variability in airway obstruction over time (change in forced expiratory volume in 1 second >/=400 mL)" and "high degree of response to bronchodilators (>200 mL and >/=12% predicted above baseline)". Minor criteria were "personal/family history of atopy and/or IgE sensitivity to >/=1 airborne allergen", "elevated blood/sputum eosinophil levels and/or increased fractional exhaled nitric oxide", "diagnosis of asthma <40 years of age"; "symptom variability", and "age (in favor of asthma)". To diagnose ACOS in asthma patients, major criteria were "persistence of airflow obstruction over time (forced expiratory volume in 1 second/forced vital capacity ratio <0.7)" and "exposure to noxious particles/gases, with >/=10 pack-years for (ex-)smokers"; minor criteria were "lack of response on acute bronchodilator test"; "reduced diffusion capacity"; "limited variability in airway obstruction"; "age >40 years"; "emphysema on chest computed tomography scan". CONCLUSION: Specific criteria were identified that may guide physicians to a more uniform diagnostic approach for ACOS in COPD or asthma patients. These criteria are largely similar to those used to prescribe inhaled corticosteroids in COPD. [less ▲]

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See detailQuadratic reformulations of nonlinear binary optimization problems
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

in Mathematical Programming (2017), 162

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these ... [more ▼]

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these problems when the objective function is a quadratic polynomial. However, no similarly efficient methods are available for the higher degree case. Since high degree objectives are becoming increasingly important in certain application areas, such as computer vision, various techniques have been recently developed to reduce the general case to the quadratic one, at the cost of increasing the number of variables. In this paper we initiate a systematic study of these quadratization approaches. We provide tight lower and upper bounds on the number of auxiliary variables needed in the worst-case for general objective functions, for bounded-degree functions, and for a restricted class of quadratizations. Our upper bounds are constructive, thus yielding new quadratization procedures. Finally, we completely characterize all ``minimal'' quadratizations of negative monomials. [less ▲]

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