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See detail68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies
Verger, Elise ULg; Drion, Pierre ULg; MEFFRE, Geneviève ULg et al

in PLoS ONE (2016)

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain ... [more ▼]

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain a unique theranostic vector for the treatment of Hepatocellular Carcinoma. METHODS: Optimal labeling conditions and composition of freeze-dried kits were defined by monitoring the radiochemical purity while varying several parameters. In vitro stability studies were carried out, as well as an in vivo biodistribution as a preliminary approach with the intra-arterial injection of 68Ga radiolabeled SBMP into the hepatic artery of DENA-induced rats followed by PET/CT imaging. RESULTS: Kits were optimized for 188Re and 68Ga with high and stable radiochemical purity (>95% and >98% respectively). The in vivo preliminary study was successful with more than 95% of activity found in the liver and mostly in the tumorous part. CONCLUSION: SBMP are a promising theranostic agent for the Selective Internal Radiation Therapy of Hepatocellular carcinoma [less ▲]

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See detailSeasonal changes and steroid control of perineuronal nets in the song control system
Cornez, Gilles ULg; Shevchouk, Olesya ULg; Madison, Farrah et al

Conference (2016, October 14)

Perineuronal nets (PNNs) are aggregations of extracellular matrix components surrounding the soma of some neurons, mainly GABAergic interneurons expressing the calcium binding protein parvalbumin (PV ... [more ▼]

Perineuronal nets (PNNs) are aggregations of extracellular matrix components surrounding the soma of some neurons, mainly GABAergic interneurons expressing the calcium binding protein parvalbumin (PV+). In mammals, the development of PNNs limits synaptogenesis around PV+ neurons and PNNs have been validated as a marker characterizing the end of critical periods for some types of learning. In oscines, song learning is limited to critical periods either during ontogeny in close-ended learners such as zebra finches or during specific phases of the annual cycle in open-ended learners such as canaries or starlings. In zebra finches, PNN expression increases when the song crystalizes and this increase is markedly inhibited if juveniles are deprived from a tutor, which is known to delay the closure of the critical period for song learning. Nothing is known however about a possible role of PNNs in adult seasonal plasticity of open-ended learners. We compared PNNs expression and their colocalization with PV+ neurons in photosensitive, photostimulated, and photorefractory starlings. Although this treatment affected as expected the testes volumes, testosterone concentrations and volumes of song control nuclei, it did not markedly change the expression of PNNs or PV+ neurons in song control or auditory nuclei. In a second experiment, brains of female canaries implanted with testosterone for 1, 2, 9, or 21 days displayed an increase of the total numbers of PV+ neurons and PNNs in HVC, the total number of PNNs in nucleus robustusarcopallialis (RA), the density of PNNs in Area X and the %PV+ neurons surrounded by PNNs in RA and Area X. Interestingly the density of PNNs in song control nuclei progressively decreases from zebra finches to canaries to starlings in parallel with the increased song plasticity in these species supporting the notion that PNNs may limit brain and thus song plasticity in a species-typical manner. [less ▲]

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See detailLes xylanases : hier et demain ?
Beckers, Yves ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 54 (1 ULg)
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See detailMachine monstrueuse. Retour sur l'excès, l'exhibition et le gros plan
Jousten, Lison ULg

Conference (2016, October 14)

La communication propose de revenir sur certains aspects monstrueux du cinématographe. À la fois vectrice et créatrice d’un imaginaire intimement associé à la machine, il s’agit principalement d’envisager ... [more ▼]

La communication propose de revenir sur certains aspects monstrueux du cinématographe. À la fois vectrice et créatrice d’un imaginaire intimement associé à la machine, il s’agit principalement d’envisager comment cette « machine à voir » (Viva Paci, 2012) est aussi étroitement liée à la question de la monstruosité. [less ▲]

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See detailA full inference toolbox to measure multivariate relative dispersion
Aerts, Stéphanie ULg; Haesbroeck, Gentiane ULg

Conference (2016, October 14)

In the univariate context, coefficients of variation (CV) are widely used to compare the dispersion of a variable in several populations. When the comparison is based on p characteristics however, side-by ... [more ▼]

In the univariate context, coefficients of variation (CV) are widely used to compare the dispersion of a variable in several populations. When the comparison is based on p characteristics however, side-by-side comparison of marginal CV’s may lead to contradictions. In this talk, we present a multivariate coefficient of variation (MCV), defined as the inverse of the Mahalanobis distance between the mean and the origin, whose usefulness is demonstrated in some applications in finance and analytical chemistry. A full inference toolbox is provided for practitioners: several parametric and non-parametric bias-correction methods are suggested and compared, and some exact and approximate confidence intervals are built and analyzed in a simulation study. Finally, in order to meet the practical need to compare MCV’s in K populations, some asymptotic statistical testing procedures are derived, whose finite-sample performance is empirically assessed. Throughout the talk, the robustness of the techniques will be discussed. As a by-product, a test statistic allowing to reliably compare K univariate CV’s even in presence of outliers will be outlined. [less ▲]

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See detailAvis d’initiative sur l’impact du TTIP sur les pays en développement
Zacharie, Arnaud; Dos Santos Costa, Vera; Coheur, Alain et al

Article for general public (2016)

La nouvelle génération de traités sur le commerce et l’investissement négociés par l’Union européenne d’une part et les Etats-Unis (TTIP) et le Canada (CETA) d’autre part auraient un impact négatif sur ... [more ▼]

La nouvelle génération de traités sur le commerce et l’investissement négociés par l’Union européenne d’une part et les Etats-Unis (TTIP) et le Canada (CETA) d’autre part auraient un impact négatif sur les pays en développement. C’est pourquoi le CWBCI recommande aux parlements et aux gouvernements de la Région wallonne, de la Région bruxelloise, de la Fédération Wallonie-Bruxelles et de la Communauté germanophone de ne pas les ratifier. [less ▲]

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See detailTreg, Th17 and γδ T cells during normal and abortive pregnancy
Polese, Barbara ULg; Gridelet, Virginie ULg; Munaut, Carine ULg et al

Poster (2016, October 14)

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See detailRadicalisation violente. Représentations , Croyances et Interventions : A la recherche de sens et de liens
Glowacz, Fabienne ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 37 (3 ULg)
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See detailZones de défection temporaire. Refigurations de Bartleby et de des Esseintes dans quelques romans contemporains
Claisse, Frédéric ULg; Huppe, Justine ULg

in TRANS : Revue de Littérature Générale et Comparée (2016), 20

Concerned by the exploitation of narrative and fiction for commercial or strategic purposes, many writers and observers wonder what power literature still has today, when the logic of capitalism took over ... [more ▼]

Concerned by the exploitation of narrative and fiction for commercial or strategic purposes, many writers and observers wonder what power literature still has today, when the logic of capitalism took over its tools and seems always one step ahead of its critical potentialities. To use Albert Hirschman’s terminology, if the possibilities of voice seem exhausted, can the same be said of the exit strategy, in a networked world precisely fortified by the constant injunction to freedom and autonomy? Moving the issue to the field of the novel, our contribution focuses on some contemporary characters’ wish to withdraw (geeks, secluded artists, autonomous activists, hermits of the virtual age, etc.), compared to emblematic literary figures of exit in the XIXth century (des Esseintes, Bartleby, Oblomov, Emma Bovary), so as to measure the changes that affected the very space of possibilities of exit, and their consequences for forms of resistance in literature. [less ▲]

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See detailDifferent and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULg

Poster (2016, October 14)

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are ... [more ▼]

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells.: We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood.We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells [less ▲]

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See detailBouger à tout âge? Oui, mais …
Cloes, Marc ULg

Conference given outside the academic context (2016)

Detailed reference viewed: 14 (1 ULg)
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See detailInfluence of short-term synoptic events and snow depth on DMS, DMSP, and DMSO dynamics in Antarctic spring sea ice
Carnat, Gauthier; Brabant, Frédéric; Dumont, Isabelle et al

in Elementa: Science of the Anthropocene (2016), 4(0), 000135

Temporal changes in the concentration profiles of dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO) were measured in pack ice from the Bellingshausen Sea (Antarctica ... [more ▼]

Temporal changes in the concentration profiles of dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO) were measured in pack ice from the Bellingshausen Sea (Antarctica) during the winter-spring transition of 2007. Two sites with contrasting snow and ice thicknesses were sampled, with high concentrations of DMS, DMSP, and DMSO observed at both sites, especially in surface ice. These high concentrations were shown to correspond to the development of a surface ice microalgal community dominated by strong DMSP producers (flagellates and dinoflagellates) following flooding of the ice cover. Several short-term synoptic events were observed and shown to influence strongly the dynamics of sea ice DMS, DMSP, and DMSO. In particular, a cold spell event was associated with drastic changes in the environmental conditions for the sea ice microbial communities and to a remarkable increase in the production of dimethylated sulfur compounds at both sites. A good correlation between all dimethylated sulfur compounds, sea ice temperature, and brine salinity suggested that the observed increase was triggered mainly by increased thermal and osmotic stresses on microalgal cells. Atmospheric forcing, by controlling sea ice temperature and hence the connectivity and instability of the brine network, was also shown to constrain the transfer of dimethylated sulfur compounds in the ice towards the ocean via brine drainage. Analysis of the two contrasting sampling sites shed light on the key role played by the snow cover in the sea ice DMS cycle. Thicker snow cover, by insulating the underlying sea ice, reduced the amplitude of environmental changes associated with the cold spell, leading to a weaker physiological response and DMS, DMSP, and DMSO production. Thicker snow also hampered the development of steep gradients in sea ice temperature and brine salinity, thereby decreasing the potential for the release of dimethylated sulfur compounds to the ocean via brine drainage. [less ▲]

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See detailCase report autour de cristalluries médicamenteuses atypiques
Castiglione, Vincent ULg; GADISSEUR, Romy ULg

Conference (2016, October 14)

We report here the cases of uncommon-shaped crystals in patient's urine. The first one is a 73years-old man with massive crystalluria observed in his microscopic urinalysis on Sedimax° (Menarini ... [more ▼]

We report here the cases of uncommon-shaped crystals in patient's urine. The first one is a 73years-old man with massive crystalluria observed in his microscopic urinalysis on Sedimax° (Menarini). Observed crystals had various shape (needle, stick, Feather...). The patient was hospitalized because of lactic acidosis due to suicide attempt by medication overdose. The following medication had been taken: prazepam, acetaminophen, tramadol and Triumeq°, a new anti-retroviral association of dolutegravir, abacavir and lamivudine. Infrared analysis of dryed urine didn"t allow to identify any common stone component, nor any medication. We further discuss about the possible implication of dolutegravir in crystalluria in this patient. Secondly, we show several N-acetylsulfamethoxazol (sulfamethoxazol metabolite) urine crystals detected in microscopic urinalysis of various patients. All had uncommon shape and were sometimes associated to acute kidney injury [less ▲]

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See detailRepeat-sales price indices for the US corporate bond market: Index quality and asset pricing tests
Beaupain, Renaud; Heck, Stéphanie ULg

Scientific conference (2016, October 14)

Detailed reference viewed: 20 (0 ULg)
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See detailExploring Metacognition as Support for Learning Transfer
Devlin, Marie; Draeger, John; Dvorakova, Lucie Sam et al

Conference (2016, October 14)

This presentation will share our efforts to investigate how metacognition might enhance the transfer of learning from one context to another. This topic is of relevance because the ability to transfer ... [more ▼]

This presentation will share our efforts to investigate how metacognition might enhance the transfer of learning from one context to another. This topic is of relevance because the ability to transfer one’s learning to new situations lies at the heart of lifelong learning and the employability of university graduates. [less ▲]

Detailed reference viewed: 27 (1 ULg)